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EC 1.1.3.39
<html><head><title>EC 1.1.3.39</title><script type="text/javascript" src="/ruxitagentjs_ICA7NVfqrux_10305250107141607.js" data-dtconfig="rid=RID_-1745185788|rpid=294930950|domain=qmul.ac.uk|reportUrl=/rb_bf91175sbx|app=79d1ebe45b56f889|cuc=wwsfiovv|mel=100000|expw=1|featureHash=ICA7NVfqrux|dpvc=1|lastModification=1739526633336|tp=500,50,0|rdnt=1|uxrgce=1|agentUri=/ruxitagentjs_ICA7NVfqrux_10305250107141607.js"></script></head> <base href="https://iubmb.qmul.ac.uk/enzyme/EC1/1/3/39.html"> <body> <center><b>IUBMB Enzyme Nomenclature</b><p> <h1><b>EC 1.1.3.39</b></h1></center> <b>Accepted name</b>: nucleoside oxidase (H<small><sub>2</sub></small>O<small><sub>2</sub></small>-forming)<p> <b>Reaction</b>: adenosine + <b>2</b> O<small><sub>2</sub></small> + H<small><sub>2</sub></small>O = 9-riburonosyladenine + <b>2</b> H<small><sub>2</sub></small>O<small><sub>2</sub></small> (overall reaction)<br> (1a) adenosine + O<small><sub>2</sub></small> = 5'-dehydroadenosine + H<small><sub>2</sub></small>O<small><sub>2</sub></small><br> (1b) 5'-dehydroadenosine + O<small><sub>2</sub></small> + H<small><sub>2</sub></small>O = 9-riburonosyladenine + H<small><sub>2</sub></small>O<small><sub>2</sub></small><p> <b>Systematic name</b>: nucleoside:oxygen 5'-oxidoreductase (H<small><sub>2</sub></small>O<small><sub>2</sub></small>-forming)<p> <b>Comments</b>: A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from <a href="28.html">EC 1.1.3.28</a>, nucleoside oxidase, as it produces hydrogen peroxide rather than water. <b>Links to other databases</b>: <a target="new" href="http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.3.39">BRENDA</a>, <a target="new" href="http://enzyme.expasy.org/EC/1.1.3.39">EXPASY</a>, <a target="new" href="http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.1.3.39">KEGG</a>, <a target="new" href="http://www.metacyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-1.1.3.39">Metacyc</a>, CAS registry number: <p> <b>References</b>:<p> 1. Koga, S., Ogawa, J., Cheng, L.Y., Choi, Y.M., Yamada, H. and Shimizu, S. Nucleoside oxidase, a hydrogen peroxide-forming oxidase, from <i>Flavobacterium meningosepticum. Appl. Environ. Microbiol</i>. 63 (1997) 4282-4286.<p> <center><small>[EC 1.1.3.39 created 2001]</small></center><p> <hr> Return to <a href="../3/">EC 1.1.3 home page</a><br> Return to <a href="../">EC 1.1 home page</a><br> Return to <a href="../../">EC 1 home page</a><br> Return to <a href="../../../">Enzymes home page</a><br> Return to <a href="../../../../">IUBMB Biochemical Nomenclature home page</a><p> </body></html>