CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-disabled skin-theme-clientpref-day vector-sticky-header-enabled vector-toc-available" lang="cs" dir="ltr"> <head> <meta charset="UTF-8"> <title>HMGB1 – Wikipedie</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-disabled skin-theme-clientpref-day vector-sticky-header-enabled vector-toc-available";var cookie=document.cookie.match(/(?:^|; )cswikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":[",\t."," \t,"],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"ČSN basic dt","wgMonthNames":["","leden","únor","březen","duben","květen","červen","červenec","srpen","září","říjen","listopad","prosinec"],"wgRequestId":"2886d43d-add2-4c8f-ba2f-d0cdaa6a5f4b","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"HMGB1","wgTitle":"HMGB1","wgCurRevisionId":20309328,"wgRevisionId":20309328,"wgArticleId":900772,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["Údržba:Články s dočasně použitou šablonou","Monitoring:Autoritní kontrola s 0 identifikátory","Transkripční faktory"],"wgPageViewLanguage":"cs","wgPageContentLanguage":"cs","wgPageContentModel":"wikitext","wgRelevantPageName":"HMGB1","wgRelevantArticleId":900772,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"cs","pageLanguageDir":"ltr","pageVariantFallbacks":"cs"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":true,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":20000,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q21130552","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":true,"wgGELevelingUpEnabledForUser":false}; RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.WikiMiniAtlas","ext.gadget.OSMmapa","ext.gadget.direct-links-to-commons","ext.gadget.ReferenceTooltips","ext.gadget.courses","ext.urlShortener.toolbar","ext.centralauth.centralautologin","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=cs&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediamessages.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=cs&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=cs&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.22"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="HMGB1 – Wikipedie"> <meta property="og:type" content="website"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//cs.m.wikipedia.org/wiki/HMGB1"> <link rel="alternate" type="application/x-wiki" title="Editovat" href="/w/index.php?title=HMGB1&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedie (cs)"> <link rel="EditURI" type="application/rsd+xml" href="//cs.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://cs.wikipedia.org/wiki/HMGB1"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.cs"> <link rel="alternate" type="application/atom+xml" title="Atom kanál Wikipedie." href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Posledn%C3%AD_zm%C4%9Bny&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-HMGB1 rootpage-HMGB1 skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Přeskočit na obsah</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Projekt"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" title="Hlavní menu" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Hlavní menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Hlavní menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Hlavní menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">přesunout do postranního panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">skrýt</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigace </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage" class="mw-list-item"><a href="/wiki/Hlavn%C3%AD_strana" title="Navštívit Hlavní stranu [z]" accesskey="z"><span>Hlavní strana</span></a></li><li id="n-help" class="mw-list-item"><a href="/wiki/N%C3%A1pov%C4%9Bda:Obsah" title="Místo, kde najdete pomoc"><span>Nápověda</span></a></li><li id="n-helpdesk" class="mw-list-item"><a href="/wiki/Wikipedie:Pot%C5%99ebuji_pomoc" title="Pokud si nevíte rady, zeptejte se ostatních"><span>Potřebuji pomoc</span></a></li><li id="n-featuredcontent" class="mw-list-item"><a href="/wiki/Wikipedie:Nejlep%C5%A1%C3%AD_%C4%8Dl%C3%A1nky" title="Přehled článků, které jsou považovány za nejlepší na české Wikipedii"><span>Nejlepší články</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:N%C3%A1hodn%C3%A1_str%C3%A1nka" title="Přejít na náhodně vybranou stránku [x]" accesskey="x"><span>Náhodný článek</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Posledn%C3%AD_zm%C4%9Bny" title="Seznam posledních změn na této wiki [r]" accesskey="r"><span>Poslední změny</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedie:Port%C3%A1l_Wikipedie" title="O projektu, jak můžete pomoci, kde hledat"><span>Komunitní portál</span></a></li><li id="n-villagepump" class="mw-list-item"><a href="/wiki/Wikipedie:Pod_l%C3%ADpou" title="Hlavní diskusní fórum"><span>Pod lípou</span></a></li><li id="n-specialpages" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Speci%C3%A1ln%C3%AD_str%C3%A1nky"><span>Speciální stránky</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Hlavn%C3%AD_strana" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedie" src="/static/images/mobile/copyright/wikipedia-wordmark-cs.svg" style="width: 7.5em; height: 1.1875em;"> <img class="mw-logo-tagline" alt="Wikipedie: Otevřená encyklopedie" src="/static/images/mobile/copyright/wikipedia-tagline-cs.svg" width="118" height="13" style="width: 7.375em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Speci%C3%A1ln%C3%AD:Hled%C3%A1n%C3%AD" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Prohledat tuto wiki [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Hledání</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Hledat na Wikipedii" aria-label="Hledat na Wikipedii" autocapitalize="sentences" title="Prohledat tuto wiki [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Speciální:Hledání"> </div> <button class="cdx-button cdx-search-input__end-button">Hledat</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Osobní nástroje"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Vzhled"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Změnit vzhled velikosti písma, šířky stránky a barvy" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Vzhled" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Vzhled</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=cs.wikipedia.org&uselang=cs" class=""><span>Podpořte Wikipedii</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Vytvo%C5%99it_%C3%BA%C4%8Det&returnto=HMGB1" title="Doporučujeme vytvořit si účet a přihlásit se, ovšem není to povinné" class=""><span>Vytvoření účtu</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speci%C3%A1ln%C3%AD:P%C5%99ihl%C3%A1sit&returnto=HMGB1" title="Doporučujeme vám přihlásit se, ovšem není to povinné. [o]" accesskey="o" class=""><span>Přihlášení</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Další možnosti" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Osobní nástroje" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Osobní nástroje</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Uživatelské menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=cs.wikipedia.org&uselang=cs"><span>Podpořte Wikipedii</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Vytvo%C5%99it_%C3%BA%C4%8Det&returnto=HMGB1" title="Doporučujeme vytvořit si účet a přihlásit se, ovšem není to povinné"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Vytvoření účtu</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:P%C5%99ihl%C3%A1sit&returnto=HMGB1" title="Doporučujeme vám přihlásit se, ovšem není to povinné. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Přihlášení</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Stránky pro odhlášené editory <a href="/wiki/N%C3%A1pov%C4%9Bda:%C3%9Avod" aria-label="Více informací o editování"><span>dozvědět se více</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Moje_p%C5%99%C3%ADsp%C4%9Bvky" title="Seznam editací provedených z této IP adresy [y]" accesskey="y"><span>Příspěvky</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Moje_diskuse" title="Diskuse o editacích provedených z této IP adresy [n]" accesskey="n"><span>Diskuse</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Projekt"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Obsah" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Obsah</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">přesunout do postranního panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">skrýt</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(úvod)</div> </a> </li> <li id="toc-Funkce" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Funkce"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Funkce</span> </div> </a> <ul id="toc-Funkce-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_při_zánětu" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Role_při_zánětu"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Role při zánětu</span> </div> </a> <ul id="toc-Role_při_zánětu-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interakce" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interakce"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Interakce</span> </div> </a> <button aria-controls="toc-Interakce-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Přepnout podsekci Interakce</span> </button> <ul id="toc-Interakce-sublist" class="vector-toc-list"> <li id="toc-Interakce_s_TLR4" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Interakce_s_TLR4"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Interakce s TLR4</span> </div> </a> <ul id="toc-Interakce_s_TLR4-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Klinický_význam" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Klinický_význam"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Klinický význam</span> </div> </a> <ul id="toc-Klinický_význam-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Obsah" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Obsah" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Přepnout obsah" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Přepnout obsah</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">HMGB1</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Přejděte k článku v jiném jazyce. Je dostupný v 10 jazycích" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-10" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">10 jazyků</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/HMGB1" title="HMGB1 – velština" lang="cy" hreflang="cy" data-title="HMGB1" data-language-autonym="Cymraeg" data-language-local-name="velština" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/High-Mobility-Group-Protein_B1" title="High-Mobility-Group-Protein B1 – němčina" lang="de" hreflang="de" data-title="High-Mobility-Group-Protein B1" data-language-autonym="Deutsch" data-language-local-name="němčina" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/HMGB1" title="HMGB1 – angličtina" lang="en" hreflang="en" data-title="HMGB1" data-language-autonym="English" data-language-local-name="angličtina" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/HMGB1" title="HMGB1 – francouzština" lang="fr" hreflang="fr" data-title="HMGB1" data-language-autonym="Français" data-language-local-name="francouzština" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/HMGB1" title="HMGB1 – galicijština" lang="gl" hreflang="gl" data-title="HMGB1" data-language-autonym="Galego" data-language-local-name="galicijština" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/HMGB1" title="HMGB1 – italština" lang="it" hreflang="it" data-title="HMGB1" data-language-autonym="Italiano" data-language-local-name="italština" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/HMGB1" title="HMGB1 – japonština" lang="ja" hreflang="ja" data-title="HMGB1" data-language-autonym="日本語" data-language-local-name="japonština" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/HMGB1" title="HMGB1 – ruština" lang="ru" hreflang="ru" data-title="HMGB1" data-language-autonym="Русский" data-language-local-name="ruština" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/HMGB1" title="HMGB1 – tatarština" lang="tt" hreflang="tt" data-title="HMGB1" data-language-autonym="Татарча / tatarça" data-language-local-name="tatarština" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/HMGB1" title="HMGB1 – ukrajinština" lang="uk" hreflang="uk" data-title="HMGB1" data-language-autonym="Українська" data-language-local-name="ukrajinština" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q21130552#sitelinks-wikipedia" title="Editovat mezijazykové odkazy" class="wbc-editpage">Upravit odkazy</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Jmenné prostory"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/HMGB1" title="Zobrazit obsahovou stránku [c]" accesskey="c"><span>Článek</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diskuse:HMGB1&action=edit&redlink=1" rel="discussion" class="new" title="Diskuse ke stránce (stránka neexistuje) [t]" accesskey="t"><span>Diskuse</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Změnit variantu jazyka" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">čeština</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Zobrazení"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/HMGB1"><span>Číst</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=HMGB1&veaction=edit" title="Editovat tuto stránku [v]" accesskey="v"><span>Editovat</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=HMGB1&action=edit" title="Editovat zdrojový kód této stránky [e]" accesskey="e"><span>Editovat zdroj</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=HMGB1&action=history" title="Starší verze této stránky. [h]" accesskey="h"><span>Zobrazit historii</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Nástroje ke stránce"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Nástroje" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Nástroje</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Nástroje</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">přesunout do postranního panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">skrýt</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Další možnosti" > <div class="vector-menu-heading"> Akce </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/HMGB1"><span>Číst</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=HMGB1&veaction=edit" title="Editovat tuto stránku [v]" accesskey="v"><span>Editovat</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=HMGB1&action=edit" title="Editovat zdrojový kód této stránky [e]" accesskey="e"><span>Editovat zdroj</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=HMGB1&action=history"><span>Zobrazit historii</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Obecné </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Co_odkazuje_na/HMGB1" title="Seznam všech wikistránek, které sem odkazují [j]" accesskey="j"><span>Odkazuje sem</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Speci%C3%A1ln%C3%AD:Souvisej%C3%ADc%C3%AD_zm%C4%9Bny/HMGB1" rel="nofollow" title="Nedávné změny stránek, na které je odkazováno [k]" accesskey="k"><span>Související změny</span></a></li><li id="t-upload" class="mw-list-item"><a href="//commons.wikimedia.org/wiki/Special:UploadWizard?uselang=cs" title="Nahrát obrázky či jiná multimédia [u]" accesskey="u"><span>Načíst soubor</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=HMGB1&oldid=20309328" title="Trvalý odkaz na současnou verzi této stránky"><span>Trvalý odkaz</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=HMGB1&action=info" title="Více informací o této stránce"><span>Informace o stránce</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Citovat&page=HMGB1&id=20309328&wpFormIdentifier=titleform" title="Informace o tom, jak citovat tuto stránku"><span>Citovat stránku</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:UrlShortener&url=https%3A%2F%2Fcs.wikipedia.org%2Fwiki%2FHMGB1"><span>Získat zkrácené URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:QrCode&url=https%3A%2F%2Fcs.wikipedia.org%2Fwiki%2FHMGB1"><span>Stáhnout QR kód</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Tisk/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:Kniha&bookcmd=book_creator&referer=HMGB1"><span>Vytvořit knihu</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Speci%C3%A1ln%C3%AD:DownloadAsPdf&page=HMGB1&action=show-download-screen"><span>Stáhnout jako PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=HMGB1&printable=yes" title="Tato stránka v podobě vhodné k tisku [p]" accesskey="p"><span>Verze k tisku</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Na jiných projektech </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q21130552" title="Odkaz na propojenou položku datového úložiště [g]" accesskey="g"><span>Položka Wikidat</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Nástroje ke stránce"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Vzhled"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Vzhled</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">přesunout do postranního panelu</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">skrýt</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Z Wikipedie, otevřené encyklopedie</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="cs" dir="ltr"><p><b>HMGB1</b> (z anglického <b>High-mobility group box 1</b>), známý také jako amphoterin, je <a href="/wiki/B%C3%ADlkovina" title="Bílkovina">protein</a> kódovaný <a href="/wiki/Gen" title="Gen">genem</a> <i>HMGB1</i>.<sup id="cite_ref-pmid8661151_1-0" class="reference"><a href="#cite_note-pmid8661151-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11279268_2-0" class="reference"><a href="#cite_note-pmid11279268-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>U člověka se <i>HMGB1</i> nachází na <a href="/wiki/Chromozom" title="Chromozom">chromozomu</a> 13q12. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Funkce">Funkce</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=1" title="Editace sekce: Funkce" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=1" title="Editovat zdrojový kód sekce Funkce"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Stejně jako <a href="/wiki/Histon" title="Histon">histony</a> patří i HMGB1 mezi neméně důležité chromatinové proteiny. V <a href="/wiki/Bun%C4%9B%C4%8Dn%C3%A9_j%C3%A1dro" title="Buněčné jádro">jádře</a> tento protein interaguje s <a href="/wiki/Nukleozom" title="Nukleozom">nukleozomy</a>, <a href="/wiki/Transkrip%C4%8Dn%C3%AD_faktor" title="Transkripční faktor">transkripčními faktory</a> a histony. <sup id="cite_ref-pmid16102963_3-0" class="reference"><a href="#cite_note-pmid16102963-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> HMGB1 má vliv na organizaci <a href="/wiki/DNA" title="DNA">DNA</a> a reguluje transkripci.<sup id="cite_ref-pmid18431461_4-0" class="reference"><a href="#cite_note-pmid18431461-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Po navázání HMGB1 dochází k ohybu DNA, což umožní vazbu dalších důležitých proteinů. Interakce HMGB1 s transkripčními faktory podporuje transkripci mnoha genů. Kooperací s nukleozomy dochází k rozbalení DNA a remodelaci chromatinu. Kontakt s "core" histony mění strukturu nukleozomů. </p><p>Přítomnost HMGB1 v jádře závisí a postranslačních modifikacích. Hyperacetylace na reziduích lysinů způsobuje translokaci proteinu do cytosolu. Na druhou stranu neacetylovaný protein zůstává v jádře. <sup id="cite_ref-pmid18431461_4-1" class="reference"><a href="#cite_note-pmid18431461-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_při_zánětu"><span id="Role_p.C5.99i_z.C3.A1n.C4.9Btu"></span>Role při zánětu</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=2" title="Editace sekce: Role při zánětu" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=2" title="Editovat zdrojový kód sekce Role při zánětu"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HMGB1 sekretují buňky imunitního systému: <a href="/wiki/Makrof%C3%A1g" title="Makrofág">makrofágové</a>, <a href="/wiki/Monocyt" title="Monocyt">monocyty</a> a <a href="/wiki/Dendritick%C3%A1_bu%C5%88ka" title="Dendritická buňka">dendritické buňky</a> a poškozené další buněčné typy <a href="/w/index.php?title=Nekonven%C4%8Dn%C3%AD_sekre%C4%8Dn%C3%AD_dr%C3%A1ha&action=edit&redlink=1" class="new" title="Nekonvenční sekreční dráha (stránka neexistuje)">nekonvenční sekreční dráhou</a>.<sup id="cite_ref-pmid18431461_4-2" class="reference"><a href="#cite_note-pmid18431461-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Aktivovaní makrofágové a monocyty sekretují HMGB1 jako mediátor prozánětlivých <a href="/wiki/Cytokin" title="Cytokin">cytokinů</a>.<sup id="cite_ref-pmid10398600_5-0" class="reference"><a href="#cite_note-pmid10398600-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> HMGB1 neutralizuje protilátky a poskytuje tak ochranu proti tkáňovému poškození a poranění způsobeném <a href="/w/index.php?title=Artritida&action=edit&redlink=1" class="new" title="Artritida (stránka neexistuje)">artritidou</a>, kolitidou, <a href="/wiki/Ischemie" title="Ischemie">ischemií</a>, <a href="/wiki/Sepse" title="Sepse">sepsí</a>, endotoxemií a <a href="/w/index.php?title=Syst%C3%A9mov%C3%BD_lupus_erythematosus&action=edit&redlink=1" class="new" title="Systémový lupus erythematosus (stránka neexistuje)">systémovým lupem</a>. Vazba HMGB1 na <a href="/wiki/TLR4" title="TLR4">TLR4</a> (z anglického Toll like receptor 4) vyvolá aktivaci makrofágů a produkci cytokinů. <sup id="cite_ref-pmid20547845_6-0" class="reference"><a href="#cite_note-pmid20547845-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19948257_7-0" class="reference"><a href="#cite_note-pmid19948257-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Amphoterin lze uplatnit jako <a href="/wiki/Adjuvans" title="Adjuvans">adjuvans</a> DNA vakcín.<sup id="cite_ref-pmid21544096_8-0" class="reference"><a href="#cite_note-pmid21544096-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interakce">Interakce</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=3" title="Editace sekce: Interakce" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=3" title="Editovat zdrojový kód sekce Interakce"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HMGB1 interaguje s <a href="/wiki/P53" title="P53">p53</a>.<sup id="cite_ref-pmid11106654_9-0" class="reference"><a href="#cite_note-pmid11106654-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11748221_10-0" class="reference"><a href="#cite_note-pmid11748221-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Amphoterin patří mezi intracelulární proteiny schopné translokace do jádra, kde váže DNA a reguluje expresi genů. Může dojít k jeho vyloučení ven z buňky a ve své extracelulární formě váže prozánětlivý receptor <a href="/w/index.php?title=RAGE&action=edit&redlink=1" class="new" title="RAGE (stránka neexistuje)">RAGE</a> (z anglického Receptor for advanced glycan end product). Vyplavení proteinu z buněk je důležité pro dva odlišné procesy: <a href="/wiki/Nekr%C3%B3za" title="Nekróza">nekrózu</a> (dochází k permeabilizaci membrány a intracelulární konstituenti difundují ven z buňky) a určitou formu aktivní sekrece indukované signalizací přes transkripční faktor <a href="/w/index.php?title=NFkappaB&action=edit&redlink=1" class="new" title="NFkappaB (stránka neexistuje)">NFkappaB</a>. </p><p>HMGB1 interaguje s ligandy TLR a cytokiny a aktivuje buňky díky spolupráci s mnoha povrchovými receptory (především <a href="/wiki/TLR2" title="TLR2">TLR2</a>, <a href="/wiki/TLR4" title="TLR4">TLR4</a>, a RAGE).<sup id="cite_ref-pmid20192808_11-0" class="reference"><a href="#cite_note-pmid20192808-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Interakce_s_TLR4">Interakce s TLR4</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=4" title="Editace sekce: Interakce s TLR4" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=4" title="Editovat zdrojový kód sekce Interakce s TLR4"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mezi receptory amphoterinu patří <a href="/wiki/Toll-like_receptor" title="Toll-like receptor">toll-like receptory</a> (TLR). Interakce HMGB1 a TLR4 vede k upregulaci NF-kappa B. Upregulace tohoto transkripčního faktoru má za následek zvýšení produkce cytokinů a jejich výlev z makrofágů. V <a href="/wiki/Neutrofil" class="mw-disambig" title="Neutrofil">neutrofilech</a> stimuluje na TLR závislou aktivaci NADPH oxidázy a tedy produkci ROS (reactive oxygen species).<sup id="cite_ref-pmid18431461_4-3" class="reference"><a href="#cite_note-pmid18431461-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16267105_12-0" class="reference"><a href="#cite_note-pmid16267105-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Komplex lipopolysacharidu a HMGB1 aktivuje TLR4 a spouští vazbu adaptorových proteinů (<a href="/w/index.php?title=MyD88&action=edit&redlink=1" class="new" title="MyD88 (stránka neexistuje)">MyD88</a>), což aktivuje signální kaskády. V neposlední řadě aktivuje MAPkinázovou kaskádu a NF-kappa B a skrze tyto kaskády produkci cytokinů a dalších prozánětlivých molekul.<sup id="cite_ref-pmid19414536_13-0" class="reference"><a href="#cite_note-pmid19414536-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid22076468_14-0" class="reference"><a href="#cite_note-pmid22076468-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Klinický_význam"><span id="Klinick.C3.BD_v.C3.BDznam"></span>Klinický význam</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=5" title="Editace sekce: Klinický význam" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=5" title="Editovat zdrojový kód sekce Klinický význam"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amphoterin je nejspíše klíčový pro léčbu rakoviny.<sup id="cite_ref-pmid14763124_15-0" class="reference"><a href="#cite_note-pmid14763124-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=6" title="Editace sekce: Reference" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=6" title="Editovat zdrojový kód sekce Reference"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-pmid8661151-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8661151_1-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Ferrari S, Finelli P, Rocchi M, Bianchi ME. The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13. <i>Genomics</i>. 1996, s. 367–71. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1996.0369">10.1006/geno.1996.0369</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/8661151"><span class="PMID">8661151</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Genomics&rft_id=info:doi/10.1006%2Fgeno.1996.0369&rft.atitle=The+active+gene+that+encodes+human+high+mobility+group+1+protein+%28HMG1%29+contains+introns+and+maps+to+chromosome+13&rft.date=1996&rft.pages=367%E2%80%9371&rft.au=Ferrari+S%2C+Finelli+P%2C+Rocchi+M%2C+Bianchi+ME"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid11279268-2"><span class="mw-cite-backlink"><a href="#cite_ref-pmid11279268_2-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Chou DK, Evans JE, Jungalwala FB. Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain. <i>J. Neurochem.</i>. 2001, s. 120–31. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1471-4159.2001.t01-1-00209.x">10.1046/j.1471-4159.2001.t01-1-00209.x</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/11279268"><span class="PMID">11279268</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Neurochem.&rft_id=info:doi/10.1046%2Fj.1471-4159.2001.t01-1-00209.x&rft.atitle=Identity+of+nuclear+high-mobility-group+protein%2C+HMG-1%2C+and+sulfoglucuronyl+carbohydrate-binding+protein%2C+SBP-1%2C+in+brain&rft.date=2001&rft.pages=120%E2%80%9331&rft.au=Chou+DK%2C+Evans+JE%2C+Jungalwala+FB"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid16102963-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid16102963_3-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Bianchi ME, Agresti A. HMG proteins: dynamic players in gene regulation and differentiation. <i>Curr. Opin. Genet. Dev.</i>. 2005, s. 496–506. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.gde.2005.08.007">10.1016/j.gde.2005.08.007</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/16102963"><span class="PMID">16102963</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Curr.+Opin.+Genet.+Dev.&rft_id=info:doi/10.1016%2Fj.gde.2005.08.007&rft.atitle=HMG+proteins%3A+dynamic+players+in+gene+regulation+and+differentiation&rft.date=2005&rft.pages=496%E2%80%93506&rft.au=Bianchi+ME%2C+Agresti+A"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid18431461-4"><span class="mw-cite-backlink">↑ <a href="#cite_ref-pmid18431461_4-0"><sup style="font-style: italic; font-weight: bold; vertical-align: top">a</sup></a> <a href="#cite_ref-pmid18431461_4-1"><sup style="font-style: italic; font-weight: bold; vertical-align: top">b</sup></a> <a href="#cite_ref-pmid18431461_4-2"><sup style="font-style: italic; font-weight: bold; vertical-align: top">c</sup></a> <a href="#cite_ref-pmid18431461_4-3"><sup style="font-style: italic; font-weight: bold; vertical-align: top">d</sup></a></span> <span class="reference-text"><cite style="font-style:normal;">Klune JR, Dhupar R, Cardinal J, Billiar TR, Tsung A. HMGB1: endogenous danger signaling. <i>Mol. Med.</i>. 2008, s. 476–84. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2119%2F2008-00034.Klune">10.2119/2008-00034.Klune</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/18431461"><span class="PMID">18431461</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Mol.+Med.&rft_id=info:doi/10.2119%2F2008-00034.Klune&rft.atitle=HMGB1%3A+endogenous+danger+signaling&rft.date=2008&rft.pages=476%E2%80%9384&rft.au=Klune+JR%2C+Dhupar+R%2C+Cardinal+J%2C+Billiar+TR%2C+Tsung+A"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid10398600-5"><span class="mw-cite-backlink"><a href="#cite_ref-pmid10398600_5-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ. HMG-1 as a late mediator of endotoxin lethality in mice. <i>Science</i>. 1999, s. 248–51. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.285.5425.248">10.1126/science.285.5425.248</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/10398600"><span class="PMID">10398600</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Science&rft_id=info:doi/10.1126%2Fscience.285.5425.248&rft.atitle=HMG-1+as+a+late+mediator+of+endotoxin+lethality+in+mice&rft.date=1999&rft.pages=248%E2%80%9351&rft.au=Wang+H%2C+Bloom+O%2C+Zhang+M%2C+Vishnubhakat+JM%2C+Ombrellino+M%2C+Che+J%2C+Frazier+A%2C+Yang+H%2C+Ivanova+S%2C+Borovikova+L%2C+Manogue+KR%2C+Faist+E%2C+Abraham+E%2C+Andersson+J%2C+Andersson+U%2C+Molina+PE%2C+Abumrad+NN%2C+Sama+A%2C+Tracey+KJ"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid20547845-6"><span class="mw-cite-backlink"><a href="#cite_ref-pmid20547845_6-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, Li J, Lu B, Chavan S, Rosas-Ballina M, Al-Abed Y, Akira S, Bierhaus A, Erlandsson-Harris H, Andersson U, Tracey KJ. A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. <i>Proc. Natl. Acad. Sci. U.S.A.</i>. 2010, s. 11942–7. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.1003893107">10.1073/pnas.1003893107</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/20547845"><span class="PMID">20547845</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft_id=info:doi/10.1073%2Fpnas.1003893107&rft.atitle=A+critical+cysteine+is+required+for+HMGB1+binding+to+Toll-like+receptor+4+and+activation+of+macrophage+cytokine+release&rft.date=2010&rft.pages=11942%E2%80%937&rft.au=Yang+H%2C+Hreggvidsdottir+HS%2C+Palmblad+K%2C+Wang+H%2C+Ochani+M%2C+Li+J%2C+Lu+B%2C+Chavan+S%2C+Rosas-Ballina+M%2C+Al-Abed+Y%2C+Akira+S%2C+Bierhaus+A%2C+Erlandsson-Harris+H%2C+Andersson+U%2C+Tracey+KJ"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid19948257-7"><span class="mw-cite-backlink"><a href="#cite_ref-pmid19948257_7-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Yang H, Tracey KJ. Targeting HMGB1 in inflammation. <i>Biochim. Biophys. Acta</i>. 2010, s. 149–56. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bbagrm.2009.11.019">10.1016/j.bbagrm.2009.11.019</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/19948257"><span class="PMID">19948257</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Biochim.+Biophys.+Acta&rft_id=info:doi/10.1016%2Fj.bbagrm.2009.11.019&rft.atitle=Targeting+HMGB1+in+inflammation&rft.date=2010&rft.pages=149%E2%80%9356&rft.au=Yang+H%2C+Tracey+KJ"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid21544096-8"><span class="mw-cite-backlink"><a href="#cite_ref-pmid21544096_8-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Fagone P, Shedlock DJ, Bao H, Kawalekar OU, Yan J, Gupta D, Morrow MP, Patel A, Kobinger GP, Muthumani K, Weiner DB. Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination. <i>Gene Ther.</i>. 2011, s. 1070–7. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fgt.2011.59">10.1038/gt.2011.59</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/21544096"><span class="PMID">21544096</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Gene+Ther.&rft_id=info:doi/10.1038%2Fgt.2011.59&rft.atitle=Molecular+adjuvant+HMGB1+enhances+anti-influenza+immunity+during+DNA+vaccination&rft.date=2011&rft.pages=1070%E2%80%937&rft.au=Fagone+P%2C+Shedlock+DJ%2C+Bao+H%2C+Kawalekar+OU%2C+Yan+J%2C+Gupta+D%2C+Morrow+MP%2C+Patel+A%2C+Kobinger+GP%2C+Muthumani+K%2C+Weiner+DB"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid11106654-9"><span class="mw-cite-backlink"><a href="#cite_ref-pmid11106654_9-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Imamura T, Izumi H, Nagatani G, Ise T, Nomoto M, Iwamoto Y, Kohno K. Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein. <i>J. Biol. Chem.</i>. 2001, s. 7534–40. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M008143200">10.1074/jbc.M008143200</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/11106654"><span class="PMID">11106654</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Biol.+Chem.&rft_id=info:doi/10.1074%2Fjbc.M008143200&rft.atitle=Interaction+with+p53+enhances+binding+of+cisplatin-modified+DNA+by+high+mobility+group+1+protein&rft.date=2001&rft.pages=7534%E2%80%9340&rft.au=Imamura+T%2C+Izumi+H%2C+Nagatani+G%2C+Ise+T%2C+Nomoto+M%2C+Iwamoto+Y%2C+Kohno+K"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid11748221-10"><span class="mw-cite-backlink"><a href="#cite_ref-pmid11748221_10-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Dintilhac A, Bernués J. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. <i>J. Biol. Chem.</i>. 2002, s. 7021–8. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M108417200">10.1074/jbc.M108417200</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/11748221"><span class="PMID">11748221</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Biol.+Chem.&rft_id=info:doi/10.1074%2Fjbc.M108417200&rft.atitle=HMGB1+interacts+with+many+apparently+unrelated+proteins+by+recognizing+short+amino+acid+sequences&rft.date=2002&rft.pages=7021%E2%80%938&rft.au=Dintilhac+A%2C+Bernu%C3%A9s+J"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid20192808-11"><span class="mw-cite-backlink"><a href="#cite_ref-pmid20192808_11-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ. HMGB1 and RAGE in inflammation and cancer. <i>Annu. Rev. Immunol.</i>. 2010, s. 367–88. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev.immunol.021908.132603">10.1146/annurev.immunol.021908.132603</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/20192808"><span class="PMID">20192808</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Annu.+Rev.+Immunol.&rft_id=info:doi/10.1146%2Fannurev.immunol.021908.132603&rft.atitle=HMGB1+and+RAGE+in+inflammation+and+cancer&rft.date=2010&rft.pages=367%E2%80%9388&rft.au=Sims+GP%2C+Rowe+DC%2C+Rietdijk+ST%2C+Herbst+R%2C+Coyle+AJ"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid16267105-12"><span class="mw-cite-backlink"><a href="#cite_ref-pmid16267105_12-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D et al. High mobility group box 1 protein interacts with multiple Toll-like receptors.. <i>Am J Physiol Cell Physiol</i>. 2006, s. C917-24. <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16267105">Dostupné online</a>. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fajpcell.00401.2005">10.1152/ajpcell.00401.2005</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/16267105"><span class="PMID">16267105</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Am+J+Physiol+Cell+Physiol&rft_id=info:doi/10.1152%2Fajpcell.00401.2005&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Feutils%2Felink.fcgi%3Fdbfrom%3Dpubmed%26tool%3Dsumsearch.org%2Fcite%26retmode%3Dref%26cmd%3Dprlinks%26id%3D16267105&rft.atitle=High+mobility+group+box+1+protein+interacts+with+multiple+Toll-like+receptors.&rft.date=2006&rft.pages=C917-24&rft.au=Park+JS%2C+Gamboni-Robertson+F%2C+He+Q%2C+Svetkauskaite+D%2C+Kim+JY%2C+Strassheim+D+et+al."><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span> </span> </li> <li id="cite_note-pmid19414536-13"><span class="mw-cite-backlink"><a href="#cite_ref-pmid19414536_13-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Bianchi ME. HMGB1 loves company.. <i>J Leukoc Biol</i>. 2009, s. 573–6. <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19414536">Dostupné online</a>. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1189%2Fjlb.1008585">10.1189/jlb.1008585</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/19414536"><span class="PMID">19414536</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J+Leukoc+Biol&rft_id=info:doi/10.1189%2Fjlb.1008585&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Feutils%2Felink.fcgi%3Fdbfrom%3Dpubmed%26tool%3Dsumsearch.org%2Fcite%26retmode%3Dref%26cmd%3Dprlinks%26id%3D19414536&rft.atitle=HMGB1+loves+company.&rft.date=2009&rft.pages=573%E2%80%936&rft.au=Bianchi+ME"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span> </span> </li> <li id="cite_note-pmid22076468-14"><span class="mw-cite-backlink"><a href="#cite_ref-pmid22076468_14-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Hreggvidsdóttir HS, Lundberg AM, Aveberger AC, Klevenvall L, Andersson U, Harris HE. High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor. <i>Mol. Med.</i>. 2012, s. 224–30. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2119%2Fmolmed.2011.00327">10.2119/molmed.2011.00327</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/22076468"><span class="PMID">22076468</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Mol.+Med.&rft_id=info:doi/10.2119%2Fmolmed.2011.00327&rft.atitle=High+mobility+group+box+protein+1+%28HMGB1%29-partner+molecule+complexes+enhance+cytokine+production+by+signaling+through+the+partner+molecule+receptor&rft.date=2012&rft.pages=224%E2%80%9330&rft.au=Hreggvidsd%C3%B3ttir+HS%2C+Lundberg+AM%2C+Aveberger+AC%2C+Klevenvall+L%2C+Andersson+U%2C+Harris+HE"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> <li id="cite_note-pmid14763124-15"><span class="mw-cite-backlink"><a href="#cite_ref-pmid14763124_15-0">↑</a></span> <span class="reference-text"><cite style="font-style:normal;">Lotze MT, DeMarco RA. Dealing with death: HMGB1 as a novel target for cancer therapy. <i>Curr Opin Investig Drugs</i>. 2003, s. 1405–9. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/14763124"><span class="PMID">14763124</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Curr+Opin+Investig+Drugs&rft.atitle=Dealing+with+death%3A+HMGB1+as+a+novel+target+for+cancer+therapy&rft.date=2003&rft.pages=1405%E2%80%939&rft.au=Lotze+MT%2C+DeMarco+RA"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HMGB1&veaction=edit&section=7" title="Editace sekce: Literatura" class="mw-editsection-visualeditor"><span>editovat</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=HMGB1&action=edit&section=7" title="Editovat zdrojový kód sekce Literatura"><span>editovat zdroj</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><cite style="font-style:normal;">Thomas JO, Travers AA. HMG1 and 2, and related 'architectural' DNA-binding proteins.. <i>Trends Biochem. Sci.</i>. 2001, s. 167–74. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0968-0004%2801%2901801-1">10.1016/S0968-0004(01)01801-1</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/11246022"><span class="PMID">11246022</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Trends+Biochem.+Sci.&rft_id=info:doi/10.1016%2FS0968-0004%2801%2901801-1&rft.atitle=HMG1+and+2%2C+and+related+%27architectural%27+DNA-binding+proteins.&rft.date=2001&rft.pages=167%E2%80%9374&rft.au=Thomas+JO%2C+Travers+AA"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Andersson U, Erlandsson-Harris H, Yang H, Tracey KJ. HMGB1 as a DNA-binding cytokine.. <i>J. Leukoc. Biol.</i>. 2003, s. 1084–91. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/12488489"><span class="PMID">12488489</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Leukoc.+Biol.&rft.atitle=HMGB1+as+a+DNA-binding+cytokine.&rft.date=2003&rft.pages=1084%E2%80%9391&rft.au=Andersson+U%2C+Erlandsson-Harris+H%2C+Yang+H%2C+Tracey+KJ"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Erlandsson Harris H, Andersson U. Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator.. <i>Eur. J. Immunol.</i>. 2004, s. 1503–12. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Feji.200424916">10.1002/eji.200424916</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/15162419"><span class="PMID">15162419</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Eur.+J.+Immunol.&rft_id=info:doi/10.1002%2Feji.200424916&rft.atitle=Mini-review%3A+The+nuclear+protein+HMGB1+as+a+proinflammatory+mediator.&rft.date=2004&rft.pages=1503%E2%80%9312&rft.au=Erlandsson+Harris+H%2C+Andersson+U"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Jiang W, Pisetsky DS. Mechanisms of Disease: the role of high-mobility group protein 1 in the pathogenesis of inflammatory arthritis.. <i>Nature clinical practice. Rheumatology</i>. 2007, s. 52–8. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fncprheum0379">10.1038/ncprheum0379</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/17203009"><span class="PMID">17203009</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Nature+clinical+practice.+Rheumatology&rft_id=info:doi/10.1038%2Fncprheum0379&rft.atitle=Mechanisms+of+Disease%3A+the+role+of+high-mobility+group+protein+1+in+the+pathogenesis+of+inflammatory+arthritis.&rft.date=2007&rft.pages=52%E2%80%938&rft.au=Jiang+W%2C+Pisetsky+DS"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Ellerman JE, Brown CK, de Vera M, <i>et al.</i>. Masquerader: high mobility group box-1 and cancer.. <i>Clin. Cancer Res.</i>. 2007, s. 2836–48. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F1078-0432.CCR-06-1953">10.1158/1078-0432.CCR-06-1953</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/17504981"><span class="PMID">17504981</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Clin.+Cancer+Res.&rft_id=info:doi/10.1158%2F1078-0432.CCR-06-1953&rft.atitle=Masquerader%3A+high+mobility+group+box-1+and+cancer.&rft.date=2007&rft.pages=2836%E2%80%9348&rft.au=Ellerman+JE%2C+Brown+CK%2C+de+Vera+M%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Fossati S, Chiarugi A. Relevance of high-mobility group protein box 1 to neurodegeneration.. <i>Int. Rev. Neurobiol.</i>. 2007, s. 137–48. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0074-7742%2807%2982007-1">10.1016/S0074-7742(07)82007-1</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/17678959"><span class="PMID">17678959</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Int.+Rev.+Neurobiol.&rft_id=info:doi/10.1016%2FS0074-7742%2807%2982007-1&rft.atitle=Relevance+of+high-mobility+group+protein+box+1+to+neurodegeneration.&rft.date=2007&rft.pages=137%E2%80%9348&rft.au=Fossati+S%2C+Chiarugi+A"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Parkkinen J, Rauvala H. Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin.. <i>J. Biol. Chem.</i>. 1991, s. 16730–5. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/1909331"><span class="PMID">1909331</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Interactions+of+plasminogen+and+tissue+plasminogen+activator+%28t-PA%29+with+amphoterin.+Enhancement+of+t-PA-catalyzed+plasminogen+activation+by+amphoterin.&rft.date=1991&rft.pages=16730%E2%80%935&rft.au=Parkkinen+J%2C+Rauvala+H"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Wen L, Huang JK, Johnson BH, Reeck GR. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.. <i>Nucleic Acids Res.</i>. 1989, s. 1197–214. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2F17.3.1197">10.1093/nar/17.3.1197</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/2922262"><span class="PMID">2922262</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Nucleic+Acids+Res.&rft_id=info:doi/10.1093%2Fnar%2F17.3.1197&rft.atitle=A+human+placental+cDNA+clone+that+encodes+nonhistone+chromosomal+protein+HMG-1.&rft.date=1989&rft.pages=1197%E2%80%93214&rft.au=Wen+L%2C+Huang+JK%2C+Johnson+BH%2C+Reeck+GR"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Bernués J, Espel E, Querol E. Identification of the core-histone-binding domains of HMG1 and HMG2.. <i>Biochim. Biophys. Acta</i>. 1986, s. 242–51. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/3697355"><span class="PMID">3697355</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Biochim.+Biophys.+Acta&rft.atitle=Identification+of+the+core-histone-binding+domains+of+HMG1+and+HMG2.&rft.date=1986&rft.pages=242%E2%80%9351&rft.au=Bernu%C3%A9s+J%2C+Espel+E%2C+Querol+E"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Ge H, Roeder RG. The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.. <i>J. Biol. Chem.</i>. 1994, s. 17136–40. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/8006019"><span class="PMID">8006019</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Biol.+Chem.&rft.atitle=The+high+mobility+group+protein+HMG1+can+reversibly+inhibit+class+II+gene+transcription+by+interaction+with+the+TATA-binding+protein.&rft.date=1994&rft.pages=17136%E2%80%9340&rft.au=Ge+H%2C+Roeder+RG"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Parkkinen J, Raulo E, Merenmies J, <i>et al.</i>. Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.. <i>J. Biol. Chem.</i>. 1993, s. 19726–38. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/8366113"><span class="PMID">8366113</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Amphoterin%2C+the+30-kDa+protein+in+a+family+of+HMG1-type+polypeptides.+Enhanced+expression+in+transformed+cells%2C+leading+edge+localization%2C+and+interactions+with+plasminogen+activation.&rft.date=1993&rft.pages=19726%E2%80%9338&rft.au=Parkkinen+J%2C+Raulo+E%2C+Merenmies+J%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Zappavigna V, Falciola L, Helmer-Citterich M, <i>et al.</i>. HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation.. <i>EMBO J.</i>. 1996, s. 4981–91. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/8890171"><span class="PMID">8890171</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=EMBO+J.&rft.atitle=HMG1+interacts+with+HOX+proteins+and+enhances+their+DNA+binding+and+transcriptional+activation.&rft.date=1996&rft.pages=4981%E2%80%9391&rft.au=Zappavigna+V%2C+Falciola+L%2C+Helmer-Citterich+M%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Xiang YY, Wang DY, Tanaka M, <i>et al.</i>. Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.. <i>Int. J. Cancer</i>. 1997, s. 1–6. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28SICI%291097-0215%2819970220%2974%3A1%3C1%3A%3AAID-IJC1%3E3.0.CO%3B2-6">10.1002/(SICI)1097-0215(19970220)74:1<1::AID-IJC1>3.0.CO;2-6</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9036861"><span class="PMID">9036861</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Int.+J.+Cancer&rft_id=info:doi/10.1002%2F%28SICI%291097-0215%2819970220%2974%3A1%3C1%3A%3AAID-IJC1%3E3.0.CO%3B2-6&rft.atitle=Expression+of+high-mobility+group-1+mRNA+in+human+gastrointestinal+adenocarcinoma+and+corresponding+non-cancerous+mucosa.&rft.date=1997&rft.pages=1%E2%80%936&rft.au=Xiang+YY%2C+Wang+DY%2C+Tanaka+M%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Rasmussen RK, Ji H, Eddes JS, <i>et al.</i>. Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.. <i>Electrophoresis</i>. 1997, s. 588–98. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Felps.1150180342">10.1002/elps.1150180342</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9150946"><span class="PMID">9150946</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Electrophoresis&rft_id=info:doi/10.1002%2Felps.1150180342&rft.atitle=Two-dimensional+electrophoretic+analysis+of+human+breast+carcinoma+proteins%3A+mapping+of+proteins+that+bind+to+the+SH3+domain+of+mixed+lineage+kinase+MLK2.&rft.date=1997&rft.pages=588%E2%80%9398&rft.au=Rasmussen+RK%2C+Ji+H%2C+Eddes+JS%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Jayaraman L, Moorthy NC, Murthy KG, <i>et al.</i>. High mobility group protein-1 (HMG-1) is a unique activator of p53.. <i>Genes Dev.</i>. 1998, s. 462–72. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.12.4.462">10.1101/gad.12.4.462</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9472015"><span class="PMID">9472015</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Genes+Dev.&rft_id=info:doi/10.1101%2Fgad.12.4.462&rft.atitle=High+mobility+group+protein-1+%28HMG-1%29+is+a+unique+activator+of+p53.&rft.date=1998&rft.pages=462%E2%80%9372&rft.au=Jayaraman+L%2C+Moorthy+NC%2C+Murthy+KG%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Milev P, Chiba A, Häring M, <i>et al.</i>. High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule.. <i>J. Biol. Chem.</i>. 1998, s. 6998–7005. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.12.6998">10.1074/jbc.273.12.6998</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9507007"><span class="PMID">9507007</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=J.+Biol.+Chem.&rft_id=info:doi/10.1074%2Fjbc.273.12.6998&rft.atitle=High+affinity+binding+and+overlapping+localization+of+neurocan+and+phosphacan%2Fprotein-tyrosine+phosphatase-zeta%2Fbeta+with+tenascin-R%2C+amphoterin%2C+and+the+heparin-binding+growth-associated+molecule.&rft.date=1998&rft.pages=6998%E2%80%937005&rft.au=Milev+P%2C+Chiba+A%2C+H%C3%A4ring+M%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Nagaki S, Yamamoto M, Yumoto Y, <i>et al.</i>. Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.. <i>Biochem. Biophys. Res. Commun.</i>. 1998, s. 137–41. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1998.8589">10.1006/bbrc.1998.8589</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9600082"><span class="PMID">9600082</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Biochem.+Biophys.+Res.+Commun.&rft_id=info:doi/10.1006%2Fbbrc.1998.8589&rft.atitle=Non-histone+chromosomal+proteins+HMG1+and+2+enhance+ligation+reaction+of+DNA+double-strand+breaks.&rft.date=1998&rft.pages=137%E2%80%9341&rft.au=Nagaki+S%2C+Yamamoto+M%2C+Yumoto+Y%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Claudio JO, Liew CC, Dempsey AA, <i>et al.</i>. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy.. <i>Genomics</i>. 1999, s. 44–52. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1998.5308">10.1006/geno.1998.5308</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9628821"><span class="PMID">9628821</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Genomics&rft_id=info:doi/10.1006%2Fgeno.1998.5308&rft.atitle=Identification+of+sequence-tagged+transcripts+differentially+expressed+within+the+human+hematopoietic+hierarchy.&rft.date=1999&rft.pages=44%E2%80%9352&rft.au=Claudio+JO%2C+Liew+CC%2C+Dempsey+AA%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Boonyaratanakornkit V, Melvin V, Prendergast P, <i>et al.</i>. High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.. <i>Mol. Cell. Biol.</i>. 1998, s. 4471–87. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/9671457"><span class="PMID">9671457</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Mol.+Cell.+Biol.&rft.atitle=High-mobility+group+chromatin+proteins+1+and+2+functionally+interact+with+steroid+hormone+receptors+to+enhance+their+DNA+binding+in+vitro+and+transcriptional+activity+in+mammalian+cells.&rft.date=1998&rft.pages=4471%E2%80%9387&rft.au=Boonyaratanakornkit+V%2C+Melvin+V%2C+Prendergast+P%2C+%27%27et+al.%27%27"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li> <li><cite style="font-style:normal;">Jiao Y, Wang HC, Fan SJ. Growth suppression and radiosensitivity increase by HMGB1 in breast cancer. <i>Acta Pharmacol. Sin.</i>. 2007, s. 1957–67. <a href="/wiki/Digital_object_identifier" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1745-7254.2007.00669.x">10.1111/j.1745-7254.2007.00669.x</a>. <a href="/wiki/PubMed" title="PubMed">PMID</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/18031610"><span class="PMID">18031610</span></a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/cs.wikipedia.org:templatecitaceperiodika&rft.jtitle=Acta+Pharmacol.+Sin.&rft_id=info:doi/10.1111%2Fj.1745-7254.2007.00669.x&rft.atitle=Growth+suppression+and+radiosensitivity+increase+by+HMGB1+in+breast+cancer&rft.date=2007&rft.pages=1957%E2%80%9367&rft.au=Jiao+Y%2C+Wang+HC%2C+Fan+SJ"><span style="display:none"> </span></span><span title="Chyba v použití šablony!" class="error" style="font-weight:bold;display:none;">Je zde použita šablona <code>{{<a href="/wiki/%C5%A0ablona:Cite_journal" title="Šablona:Cite journal">Cite journal</a>}}</code> označená jako k „pouze dočasnému použití“.</span></li></ul> <style data-mw-deduplicate="TemplateStyles:r23078045">.mw-parser-output .navbox2{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox2 .navbox2{margin-top:0}.mw-parser-output .navbox2+.navbox2{margin-top:-1px}.mw-parser-output .navbox2-inner,.mw-parser-output .navbox2-subgroup{width:100%}.mw-parser-output .navbox2-group,.mw-parser-output .navbox2-title,.mw-parser-output .navbox2-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output th.navbox2-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox2,.mw-parser-output .navbox2-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox2-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output tr+tr>.navbox2-abovebelow,.mw-parser-output tr+tr>.navbox2-group,.mw-parser-output tr+tr>.navbox2-image,.mw-parser-output tr+tr>.navbox2-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox2 th,.mw-parser-output .navbox2-title{background-color:#e0e0e0}.mw-parser-output .navbox2-abovebelow,.mw-parser-output th.navbox2-group,.mw-parser-output .navbox2-subgroup .navbox2-title{background-color:#e7e7e7}.mw-parser-output .navbox2-subgroup .navbox2-title{font-size:88%}.mw-parser-output .navbox2-subgroup .navbox2-group,.mw-parser-output .navbox2-subgroup .navbox2-abovebelow{background-color:#f0f0f0}.mw-parser-output .navbox2-even{background-color:#f7f7f7}.mw-parser-output .navbox2-odd{background-color:transparent}.mw-parser-output .navbox2 .hlist td dl,.mw-parser-output .navbox2 .hlist td ol,.mw-parser-output .navbox2 .hlist td ul,.mw-parser-output .navbox2 td.hlist dl,.mw-parser-output .navbox2 td.hlist ol,.mw-parser-output .navbox2 td.hlist ul{padding:0.125em 0}</style>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Citováno z „<a dir="ltr" href="https://cs.wikipedia.org/w/index.php?title=HMGB1&oldid=20309328">https://cs.wikipedia.org/w/index.php?title=HMGB1&oldid=20309328</a>“</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/N%C3%A1pov%C4%9Bda:Kategorie" title="Nápověda:Kategorie">Kategorie</a>: <ul><li><a href="/wiki/Kategorie:Transkrip%C4%8Dn%C3%AD_faktory" title="Kategorie:Transkripční faktory">Transkripční faktory</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Skryté kategorie: <ul><li><a href="/wiki/Kategorie:%C3%9Adr%C5%BEba:%C4%8Cl%C3%A1nky_s_do%C4%8Dasn%C4%9B_pou%C5%BEitou_%C5%A1ablonou" title="Kategorie:Údržba:Články s dočasně použitou šablonou">Údržba:Články s dočasně použitou šablonou</a></li><li><a href="/wiki/Kategorie:Monitoring:Autoritn%C3%AD_kontrola_s_0_identifik%C3%A1tory" title="Kategorie:Monitoring:Autoritní kontrola s 0 identifikátory">Monitoring:Autoritní kontrola s 0 identifikátory</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Stránka byla naposledy editována 6. 8. 2021 v 12:35.</li> <li id="footer-info-copyright">Text je dostupný pod <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.cs">licencí Creative Commons Uveďte původ – Zachovejte licenci</a>, případně za dalších podmínek. Podrobnosti naleznete na stránce <a class="external text" href="https://foundation.wikimedia.org/wiki/Policy:Terms_of_Use/cs">Podmínky užití</a>.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Ochrana osobních údajů</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedie">O Wikipedii</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedie:Vylou%C4%8Den%C3%AD_odpov%C4%9Bdnosti">Vyloučení odpovědnosti</a></li> <li id="footer-places-contact"><a href="//cs.wikipedia.org/wiki/Wikipedie:Kontakt">Kontaktujte Wikipedii</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Kodex chování</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Vývojáři</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/cs.wikipedia.org">Statistiky</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Prohlášení o cookies</a></li> <li id="footer-places-mobileview"><a href="//cs.m.wikipedia.org/w/index.php?title=HMGB1&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobilní verze</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://www.wikimedia.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><picture><source media="(min-width: 500px)" srcset="/static/images/footer/wikimedia-button.svg" width="84" height="29"><img src="/static/images/footer/wikimedia.svg" width="25" height="25" alt="Wikimedia Foundation" lang="en" loading="lazy"></picture></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><picture><source media="(min-width: 500px)" srcset="/w/resources/assets/poweredby_mediawiki.svg" width="88" height="31"><img src="/w/resources/assets/mediawiki_compact.svg" alt="Powered by MediaWiki" lang="en" width="25" height="25" loading="lazy"></picture></a></li> </ul> </footer> </div> </div> </div> <div class="vector-header-container vector-sticky-header-container"> <div id="vector-sticky-header" class="vector-sticky-header"> <div class="vector-sticky-header-start"> <div class="vector-sticky-header-icon-start vector-button-flush-left vector-button-flush-right" aria-hidden="true"> <button class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-sticky-header-search-toggle" tabindex="-1" data-event-name="ui.vector-sticky-search-form.icon"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Hledání</span> </button> </div> <div role="search" class="vector-search-box-vue vector-search-box-show-thumbnail vector-search-box"> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail"> <form action="/w/index.php" id="vector-sticky-search-form" class="cdx-search-input cdx-search-input--has-end-button"> <div class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Hledat na Wikipedii"> <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Speciální:Hledání"> </div> <button class="cdx-button cdx-search-input__end-button">Hledat</button> </form> </div> </div> </div> <div class="vector-sticky-header-context-bar"> <nav aria-label="Obsah" class="vector-toc-landmark"> <div id="vector-sticky-header-toc" class="vector-dropdown mw-portlet mw-portlet-sticky-header-toc vector-sticky-header-toc vector-button-flush-left" > <input type="checkbox" id="vector-sticky-header-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-sticky-header-toc" class="vector-dropdown-checkbox " aria-label="Přepnout obsah" > <label id="vector-sticky-header-toc-label" for="vector-sticky-header-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Přepnout obsah</span> </label> <div class="vector-dropdown-content"> <div id="vector-sticky-header-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div class="vector-sticky-header-context-bar-primary" aria-hidden="true" ><span class="mw-page-title-main">HMGB1</span></div> </div> </div> <div class="vector-sticky-header-end" aria-hidden="true"> <div class="vector-sticky-header-icons"> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-talk-sticky-header" tabindex="-1" data-event-name="talk-sticky-header"><span class="vector-icon mw-ui-icon-speechBubbles mw-ui-icon-wikimedia-speechBubbles"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-subject-sticky-header" tabindex="-1" data-event-name="subject-sticky-header"><span class="vector-icon mw-ui-icon-article mw-ui-icon-wikimedia-article"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-history-sticky-header" tabindex="-1" data-event-name="history-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-history mw-ui-icon-wikimedia-wikimedia-history"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only mw-watchlink" id="ca-watchstar-sticky-header" tabindex="-1" data-event-name="watch-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-star mw-ui-icon-wikimedia-wikimedia-star"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-ve-edit-sticky-header" tabindex="-1" data-event-name="ve-edit-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-edit mw-ui-icon-wikimedia-wikimedia-edit"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-edit-sticky-header" tabindex="-1" data-event-name="wikitext-edit-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-wikiText mw-ui-icon-wikimedia-wikimedia-wikiText"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-viewsource-sticky-header" tabindex="-1" data-event-name="ve-edit-protected-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-editLock mw-ui-icon-wikimedia-wikimedia-editLock"></span> <span></span> </a> </div> <div class="vector-sticky-header-buttons"> <button class="cdx-button cdx-button--weight-quiet mw-interlanguage-selector" id="p-lang-btn-sticky-header" tabindex="-1" data-event-name="ui.dropdown-p-lang-btn-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-language mw-ui-icon-wikimedia-wikimedia-language"></span> <span>10 jazyků</span> </button> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive" id="ca-addsection-sticky-header" tabindex="-1" data-event-name="addsection-sticky-header"><span class="vector-icon mw-ui-icon-speechBubbleAdd-progressive mw-ui-icon-wikimedia-speechBubbleAdd-progressive"></span> <span>Přidat téma</span> </a> </div> <div class="vector-sticky-header-icon-end"> <div class="vector-user-links"> </div> </div> </div> </div> </div> <div class="mw-portlet mw-portlet-dock-bottom emptyPortlet" id="p-dock-bottom"> <ul> </ul> </div> <script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-5c6f46dcf-djvq8","wgBackendResponseTime":142,"wgPageParseReport":{"limitreport":{"cputime":"0.279","walltime":"0.308","ppvisitednodes":{"value":8373,"limit":1000000},"postexpandincludesize":{"value":184636,"limit":2097152},"templateargumentsize":{"value":36746,"limit":2097152},"expansiondepth":{"value":19,"limit":100},"expensivefunctioncount":{"value":1,"limit":500},"unstrip-depth":{"value":0,"limit":20},"unstrip-size":{"value":28644,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 256.552 1 -total"," 65.06% 166.905 35 Šablona:Cite_journal"," 31.02% 79.592 1 Šablona:Autoritní_data"," 28.81% 73.909 35 Šablona:Cizojazyčná_verze_šablony"," 27.09% 69.500 35 Šablona:Pouze_dočasné_použití"," 24.63% 63.187 35 Šablona:Chyba"," 15.95% 40.922 35 Šablona:Šablona"," 7.58% 19.458 105 Šablona:Šablona/bez_subst"," 4.80% 12.321 140 Šablona:Zleva"," 3.77% 9.677 35 Šablona:Povinný_stacktrace"]},"scribunto":{"limitreport-timeusage":{"value":"0.114","limit":"10.000"},"limitreport-memusage":{"value":1517178,"limit":52428800}},"cachereport":{"origin":"mw-web.codfw.main-866f5d587f-7jcx2","timestamp":"20250328062740","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"HMGB1","url":"https:\/\/cs.wikipedia.org\/wiki\/HMGB1","sameAs":"http:\/\/www.wikidata.org\/entity\/Q21130552","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q21130552","author":{"@type":"Organization","name":"P\u0159isp\u011bvatel\u00e9 projekt\u016f Wikimedia"},"publisher":{"@type":"Organization","name":"nadace Wikimedia","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2013-04-17T12:52:33Z","dateModified":"2021-08-06T10:35:23Z"}</script> </body> </html>