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Indena | Manufacturing facilities
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xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> <span class="label">Back</span> </a> <div class="left-zone"> <h2>Products</h2> <p>100 years of botanical excellence mean a wide range of botanical derivatives. Search for them.</p> <a class="simple-cta menu-cta " data-parent="Products" href="https://www.indena.com/products/"> <span class="label">Go to section</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </div> <div class="links-row"> <div class="links-col"> <ul class="submenu"> <li> <a class="menu-button " data-parent="Products" href="https://www.indena.com/products/pharmaceuticals/" > <span>Pharmaceuticals</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> <li> <a class="menu-button " data-parent="Products" href="https://www.indena.com/products/nutraceuticals/" data-img-id="child-item-1113"> <span>Nutraceuticals</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> <li> <a class="menu-button children " data-parent="Products" href="https://www.indena.com/products/phytosome/" > <span>Indena Phytosome™ Technology</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> </ul> </div> </div> </div> </div> </div> <div class="wd-megamenu" id="item-983"> <div class="megamenu-overlay"> <div class="megamenu-content center-grid no-h-padding "> <a class="back-menu d-lg-none" role="button"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> <span class="label">Back</span> </a> <div class="left-zone"> <h2>CDMO Service</h2> <p></p> <a class="simple-cta menu-cta " data-parent="CDMO" href="https://www.indena.com/cdmo/"> <span class="label">Go to section</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </div> <div class="links-row"> <div class="links-col"> <ul class="submenu"> </ul> </div> </div> </div> </div> </div> <div class="wd-megamenu" id="item-9251"> <div class="megamenu-overlay"> <div class="megamenu-content center-grid no-h-padding "> <a class="back-menu d-lg-none" role="button"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> <span class="label">Back</span> </a> <div class="left-zone"> <h2>Things to watch</h2> <p></p> <a class="simple-cta menu-cta " data-parent="Things to watch" href="https://www.indena.com/things-to-watch/"> <span class="label">Go to section</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </div> <div class="links-row"> <div class="links-col"> <ul class="submenu"> </ul> </div> </div> </div> </div> </div> <div class="wd-megamenu" id="item-2258"> <div class="megamenu-overlay"> <div class="megamenu-content center-grid no-h-padding half-bottom"> <a class="back-menu d-lg-none" role="button"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> <span class="label">Back</span> </a> <div class="left-zone"> <h2>Media and news</h2> <p>Here is the right place where you can read all the latest news and information about Indena’s world.</p> </div> <div class="links-row"> <div class="links-col col-25"> <ul class="submenu"> <li> <a class="menu-button " data-parent="Media and Events" href="https://www.indena.com/media-and-events/news/"> <span>News</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> <li> <a class="menu-button " data-parent="Media and Events" href="https://www.indena.com/media-and-events/press-releases/"> <span>Press Releases</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> <li> <a class="menu-button " data-parent="Media and Events" href="https://www.indena.com/media-and-events/ad-campaigns/"> <span>AD Campaigns</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> <li> <a class="menu-button " data-parent="Media and Events" href="https://www.indena.com/media-and-events/presskit/"> <span>Press Kits</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> </ul> </div> <div class="right-zone col-25"> <h2>Events</h2> <p>Take a look on Indena’s Calendar. You will always be aware of our upcoming events.</p> </div> <div class="links-col col-25"> <ul class="submenu"> <li> <a class="menu-button " data-parent="Media and Events" href="https://www.indena.com/media-and-events/events-calendar/"> <span>Events Calendar</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> <li> <a class="menu-button " data-parent="Media and Events" href="https://www.indena.com/media-and-events/events-advisory-board/"> <span>Advisory Board</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </li> </ul> </div> </div> </div> </div> <div class="mega-footer"> <div class="megafooter-content center-grid no-h-padding"> <div class="left"> <h2>Indena’s Filestore</h2> </div> <div class="text"> <p>Browse all Indena’s documents about products, events, company information and so much more.</p> <a class="simple-cta menu-cta " data-parent="Media and Events" href="https://www.indena.com/media-and-events/indenas-filestore/"> <span class="label">Go to section</span> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </div> </div> </div> </div> </header> <main id="main"> <div class="color-change-wrapper"> <!--hero--> <section class="hero-page positive white" data-bg="white"> <div class="hero-page-wrapper"> <div class="hero-page-viewport hero-variation hero-page-gradient"> <div class="img-wrapper"> <div class="padding-ratio"> <picture class="img-fill"> <source srcset="https://www.indena.com/indena_files/2020/12/mfg-plants-hero-lg-1.jpg" media="(min-width: 992px)"> <source srcset="https://www.indena.com/indena_files/2021/02/mfg-plants-hero-sm-2.jpg" media="(min-width: 320px)"> <img class="fill" src="https://www.indena.com/indena_files/2020/12/mfg-plants-hero-lg-1.jpg" alt="MANUFACTURING FACILITIES"> </picture> </div> </div> <div class="hero-page-text"> <div class="hero-page-title "> <nav class="breadcrumbs"> <ul class="page-tree"><li><a href="https://www.indena.com">Home</a></li> <li>Innovation</li> <li>Manufacturing facilities</li></ul> </nav> <p class="category">MANUFACTURING FACILITIES</p> <h1 class="">When Technology and Beauty are One</h1> </div> <div class="hero-page-content"> <p class="">When Technology and Beauty are One</p> </div> <div class="hero-page-scroll"> <p> <svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> <span class="label">Scroll to see more</span> </p> </div> </div> </div> <div class="hero-page-search-share"> <div class="share-contact"> <div class="button-share-wrapper"> <button class="share-button"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-share"></use></svg><span>Share</span> </button> </div> <div class="share-drop-wrapper"> <div class="share-items"> <a class="social-item" onclick="javascript:popupCenter('https://www.facebook.com/sharer/sharer.php?u=https://www.indena.com/innovation/manufacturing-facilities/','Facebook Share', '540', '400');return false;" href="https://www.facebook.com/sharer/sharer.php?u=https://www.indena.com/innovation/manufacturing-facilities/" target="_blank" title="Facebook"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-social-facebook"></use></svg><span>Facebook</span> </a> <a class="social-item" onclick="javascript:popupCenter('http://www.linkedin.com/shareArticle?mini=true&url=https://www.indena.com/innovation/manufacturing-facilities/','Share on LinkedIn', '540', '400');return false;" href="http://www.linkedin.com/shareArticle?mini=true&url=https://www.indena.com/innovation/manufacturing-facilities/" target="_blank" title="Linkedin"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/sprite-new.svg#linkedin"></use></svg><span>Linkedin</span> </a> <a class="social-item" onclick="javascript:popupCenter('https://twitter.com/share?&url=https://www.indena.com/innovation/manufacturing-facilities/','Tweet', '540', '400');return false;" href="https://twitter.com/share?&url=https://www.indena.com/innovation/manufacturing-facilities/" target="_blank" title="Twitter"> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-social-twitter"></use></svg><span>Twitter</span> </a> </div> </div> <script> var popupCenter = function(url, title, w, h) { // Fixes dual-screen position Most browsers Firefox var dualScreenLeft = window.screenLeft !== undefined ? 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Yet ours were designed with bright steel, symmetrical patterns and textures – to reveal the surprising beauty of our industry and science.<br><br></strong>We devote great effort and resources <span>to ensuring good manufacturing practices, safety and sustainability in its facilities and production plants.</span><br><br><span>This is why the company counts numerous certifications.<br><br></span><span>Our facilities in Milano, Settala, Palestro and Tours are certified GMP, ISO 14001, ISO 45001, AEO validated and FDA Food Facility registered. Facilities in Settala, Palestro and Tours are also certified Kosher and Halal. Facilities in Milan, Settala and Palestro are certified ISO 22000. Facilities in Milan and Settala are C-TPAT validated. Finally, our facility in Tours is also FSSC 22000 certified and the one in India is GMP certified.</span></p> </div> </div> </div> </div> </section> <section id="part_1" class="gallery white" data-bg="white" > <div class="gallery-wrapper"> <div class="gallery-content"> <div class="swiper-container"> <div class="swiper-wrapper"> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-1MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-2MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-3MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-4MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-5MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-6MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> <div class="swiper-slide gallery-slide"> <div class="img-wrapper"> <div class="padding-ratio"> <img class="fill lazy" data-src="https://www.indena.com/indena_files/2020/12/gallery-7MM.jpg" alt=""> <div class="img-loader"></div> </div> </div> </div> </div> <button class="button-carousel double"> <span> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </span> </button> </div> <div class="swiper-timer"></div> </div> </div> </section> <div id="part_2" class="h2-anchor-wrapper padding-top padding-bottom offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_2">Plants for Plants</h2> </div> <section id="part_3" class="complete-text-block offset-left offset-right white " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <p class="pre-title">INNOVATION</p> <div class="text-row"> <div class="left"> <h2><strong>Plants for Plants<sup>®</sup></strong></h2> </div> <div class="right"> <p>Indena’s manufacturing and scientific research services for the extraction, isolation and purification of natural derivatives include <strong>a full range of manufacturing capabilities for pharmaceutical and food-grade ingredients.</strong> The combination of our expertise with state-of-the-art facilities allows us to deliver products and processes from small-scale orders to large commercial manufacturing supplies.</p> </div> </div> </div> </div> </section> <section id="part_4" class="banner-download padding-bottom offset-left offset-right white" data-bg="white" > <div class="banner-download-wrapper"> <div class="container-fluid"> <div class="row"> <div class="col-12 col-md-3 image-wrapper"> <img src="https://www.indena.com/indena_files/2021/01/catalogo-generico.png" alt="PLANTS FOR PLANTS<sup>®</sup> Capabilities"> </div> <div class="col-12 col-md-9 col-lg-8 content-wrapper"> <div class="content"> <div class="text" data-aos="fade-up" data-aos-duration="1000"> <h2>PLANTS FOR PLANTS<sup>®</sup> Capabilities</h2> </div> <div class="cta"> <div class="btn-wrapper" data-aos="fade-up" data-aos-duration="1000"> <div class="wd-button-wrapper"> <a id="open-filebanner-4-1" role="link" class="wd-button primary" href="https://www.indena.com/indena_files/2020/12/plants_for_plants_capabilities.pdf" target="_blank"> <span class="button-label">Download</span> <svg class="icon"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-download"></use></svg> </a> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section id="part_5" class="img-responsive-section padding-bottom offset-left offset-right white" data-bg="white" > <div class="img-responsive-section-wrapper"> <div class="img-wrapper"> <div class="padding-ratio "> <picture class="img-fill"> <img class="lazy fill" data-src="https://www.indena.com/indena_files/2020/12/plants-for-plantsMM.jpg" alt="plants-for-plants"> <div class="img-loader"></div> </picture> </div> </div> </div> </section> <div id="part_6" class="h2-anchor-wrapper padding-bottom offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_6">Innovation</h2> </div> <section id="part_7" class="complete-text-block offset-left offset-right white " data-bg="white" > <div class="complete-text-block-wrapper"> <div class="text-zone" data-aos="fade-up" data-aos-duration="1000"> <p class="pre-title">INNOVATION</p> <div class="text-row"> <div class="left"> <h2><strong>Making Flexibility Count</strong></h2> </div> <div class="right"> <p>With <strong>high quality deeply ingrained in our approach</strong> thanks to the application of cGMPs and supervision from worldwide health authorities, Indena has always maintained a smart balance between the competing demands of cost and time. <strong>In this context, flexibility is a strength and value in and of itself.<br></strong>Whether it’s single-use systems, continuous manufacturing or modular design, embracing and <strong>adapting to new technology is critical in today’s reality, where agility reigns supreme</strong>. This can be seen across a wide range of application areas, even beyond the field of natural derivatives, from new projects under development to new manufacturing facilities.</p> <p> </p> <p> </p> </div> </div> </div> </div> </section> <section id="part_8" class="text-image-block offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>Endless Innovation</h3> <p>We are the world’s leading company in the identification, development and production of active principles derived from plants, for use in the pharmaceutical, health food and personal care industries. Yet we continue to invest, every year, in innovative technologies and services to further broaden our offer.<br /> <br /> <b>Indena’s facilities include separated areas authorized for handling pharmaceutical and food-grade natural derivatives, and the company’s Quality System ensures compliance with both cGMPs and Hazard Analysis and Critical Control Points (HACCP) guidelines.</b></p> <a id="cta-textmedia-8" role="link" class="simple-cta" href="/innovation/quality/" target="_self"> <span class="label">DISCOVER OUR QUALITY</span><svg class="icon sm"><use xlink:href="https://www.indena.com/indena_theme/assets/svg/wd-sprite.svg#wd-arrow-r"></use></svg> </a> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/endless-innovationMM-1.jpg" alt="Endless Innovation"> <div class="img-loader"></div> </div> </div> </div> </section> <div id="part_9" class="h2-anchor-wrapper padding-top padding-bottom offset-left offset-right" data-bg="white"> <h2 class="js-anchor" id="section_9">Equipments</h2> </div> <section id="part_10" class="text-image-block offset-left offset-right white specular " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>Our Plant Equipment</h3> <p>As for equipment, over the years Indena has developed <b>innovative suites in its main manufacturing site, located in Settala (Milan, Italy): a new HPAPI kilo lab, a pilot pharmaceutical plant and a PSD2 spray dryer. Moreover, we have upgraded our fermentation plant to multipurpose use. </b><br /> <br /> Indena’s manufacturing site was already equipped with large-scale isolators, originally designed for the production of hundreds of kilos per year of semisynthetic HPAPIs with an Occupational Exposure Limit (OEL) of 800 ng/m<sup>3</sup>; these have now been upgraded to handle even more toxic (natural and synthetic) compounds, with an OEL in the range of 150 ng/m<sup>3</sup>. These large-scale suites have been complemented by opening <b>a brand new kilo lab </b>(LK2, in addition to the existing LK1) devoted to extremely potent compounds, with an OEL of 20 ng/m<sup>3</sup>.<br /> </p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/our-plant-equipmentMM.jpg" alt="Our Plant Equipment"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_11" class="text-image-block offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>The New Pilot Pharmaceutical Plant</h3> <p><p>In addition, Indena has opened a brand new pilot suite with a high degree of flexibility for non-potent compounds, in terms of scale and operational conditions. This entailed the installation of a <strong>pilot pharmaceutical plant</strong>suitable for the GMP production of clinical batches, the manufacturing of non-potent intermediates and commercial batches requiring yearly production volumes in the range of tens of kilos.</p></p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/the-new-pilot-pharmaceuticals-plantV.jpg" alt="The New Pilot Pharmaceutical Plant"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_12" class="text-image-block offset-left offset-right white specular " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>The New Gea PSD2 Spray Dryer</h3> <p><p>Furthermore, as a natural extension of a technology it had already implemented for several years, the company installed a <b>Gea PSD2 spray dryer</b> to complement a large-scale spray dryer working with organic solvents, dating back to the early 1990s. The PSD2 is a medium-size equipment for clinical and commercial use, which can handle class-2 organic solvents and is designed to carry out the production of APIs and pre-formulated APIs (through spray drying in the presence of excipients, classified as drug product intermediates) with an OEL equal to or greater than 10 μg/m<sup>3</sup>.<br></p></p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2021/01/the-new-gea-psd2-dpray-dryer-lg.jpg" alt="The New Gea PSD2 Spray Dryer"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_13" class="text-image-block padding-bottom offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text positive"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>A Multipurpose Fermentation Plant</h3> <p><p>To complete this plan, with the goal to increase and improve our services to customers, <b>we upgraded an existing fermentation plant (once fully dedicated to a proprietary bio-transformation), making it multipurpose.</b></p><p></p><p>The plant features industrial equipment with capacity ranging from 1,000 to 20,000 liters, and is supported by a 10-liter laboratory as well as 100- and 150-liter pilot scale fermenters; its outstanding peculiarity is the ability to ferment toxic compounds. It is therefore well integrated with existing HPAPI suites, where downstream activities take place.</p></p> </div> </div> <div class="image"> <div class="image-wrapper"> <img class="lazy" data-src="https://www.indena.com/indena_files/2020/12/a-mulripurpose-fermetation.-planTMM-2.jpg" alt="A Multipurpose Fermentation Plant"> <div class="img-loader"></div> </div> </div> </div> </section> <section id="part_16" class="text-image-block offset-left offset-right white " data-bg="white" > <div class="text-image-block-wrapper"> <div class="text negative"> <div class="text-content" data-aos="fade-up" data-aos-duration="1000"> <h3>TAKE A LOOK AT INDENA’S R&D</h3> <p>Nature offers us boundless inspiration for brilliant ideas. 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