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11.3.53-.52-4.75-4.75-.34-.32-.05-.05.38-.38L6.19.53 5.66 0 0 5.65z" fill="#151515" fill-rule="evenodd" /> </svg> Innovation </a> <a class="primary-nav__drop-down-anchor-heading" href="/en-gb/innovation/our-leading-scientists/"> Our leading scientists <svg width="20" height="15" xmlns="http://www.w3.org/2000/svg"> <path d="M12.23 13.94 18.16 8l-.08-.08a.27.27 0 0 1-.2.08H.61v-.92h17.27c.07 0 .14.02.19.07l.08-.08-5.92-5.92.66-.66 6.4 6.4.65.65-.66.66-6.4 6.4-.65-.66Z" fill="#F36633" fill-rule="evenodd" /> </svg> </a> </div> <div class="primary-nav__drop-down-links--scroll"> <ul class="primary-nav__drop-down-sub-menu-list"> <!-- This has primary-nav__drop-down-item-has-children so will open sub nav level 3 --> <li class="primary-nav__drop-down-item primary-nav__link-no-children "> <a href="/en-gb/innovation/our-leading-scientists/tony-wood/"> <span>Dr Tony Wood</span> </a> </li> <li class="primary-nav__drop-down-item primary-nav__link-no-children "> <a href="/en-gb/innovation/our-leading-scientists/philip-dormitzer/"> <span>Dr Philip Dormitzer</span> </a> </li> <li class="primary-nav__drop-down-item primary-nav__link-no-children "> <a href="/en-gb/innovation/our-leading-scientists/sabine-luik/"> <span>Dr Sabine Luik</span> </a> </li> <li class="primary-nav__drop-down-item primary-nav__link-no-children "> <a href="/en-gb/innovation/our-leading-scientists/hesham-abdullah/"> <span>Dr Hesham Ahmed Abdullah</span> </a> </li> </ul> </div> </div> </li> <li class="primary-nav__drop-down-item primary-nav__link-no-children "> <a href="/en-gb/innovation/research-and-development-approach/"> <span> Research and development approach </span> </a> </li> <li class="primary-nav__drop-down-item primary-nav__link-no-children primary-nav__drop-down--active-state"> <a href="/en-gb/innovation/pipeline/"> <span> Pipeline </span> </a> </li> <li class="primary-nav__drop-down-item primary-nav__drop-down-item-has-children "> <a 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class="primary-nav__drop-down-item primary-nav__drop-down-item-has-children "> <a href="/en-gb/innovation/trials/"> <span> Clinical trials at GSK </span> </a> <div class="primary-nav__drop-down-sub-menu"> <div class="primary-nav__drop-down-links-header"> <a href="" class="primary-nav__drop-down-back"> <!-- This is mobile only, it refers to the parent menu, in this case the Company menu --> <svg width="7" height="12" xmlns="http://www.w3.org/2000/svg"> <path d="m5.66 11.3.53-.52-4.75-4.75-.34-.32-.05-.05.38-.38L6.19.53 5.66 0 0 5.65z" fill="#151515" fill-rule="evenodd" /> </svg> Innovation </a> <a class="primary-nav__drop-down-anchor-heading" href="/en-gb/innovation/trials/"> Clinical trials at GSK <svg width="20" height="15" xmlns="http://www.w3.org/2000/svg"> <path d="M12.23 13.94 18.16 8l-.08-.08a.27.27 0 0 1-.2.08H.61v-.92h17.27c.07 0 .14.02.19.07l.08-.08-5.92-5.92.66-.66 6.4 6.4.65.65-.66.66-6.4 6.4-.65-.66Z" fill="#F36633" fill-rule="evenodd" /> </svg> </a> </div> <div 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class="pipeline__export"> <h1>Pipeline</h1> <ul> <li> <a href="/media/11635/3q2024-pipeline-list.xlsx" title="Download in XLSX format (18.9KB)" download="3q2024-pipeline-list.xlsx"> Q3 2024 Pipeline List <span class="download-filesize">( XLSX - 18.9KB )</span> <span class="icon icon--download"></span> </a> </li> </ul> </div> </div> <div class="grid-cell desktop-span-6 tablet-span-12"> <div class="pipeline__desc"> <p>At GSK, our portfolio and pipeline is focused in developing vaccines and medicines in four core therapeutic areas, which are the areas of human health we focus on to prevent and treat disease: infectious diseases, HIV, respiratory/immunology and oncology.</p> <p>We also consider opportunities in organic research and business development in other therapeutic areas, where there is a patient need and where the opportunity fits with our focus on human genetics, genomics, and the science of the immune system.</p> </div> </div> </div> </div> </div> <article> <div class="pipeline-container"> <div class="main-container"> <div class="pipeline-tabs"> <div class="pipeline-tabs__tabs"> <ul class="pipeline-tabs__list" role="tablist" aria-label="Pipeline" style=""> <li class="pipeline-tabs__item pipeline-tabs__item--active" data-target="our-pipeline" role="presentation"> <a class="pipeline-tabs__button" title="Our pipeline" href="#our-pipeline" role="tab" id="our-pipeline-tab" aria-controls="our-pipeline" aria-selected="true">Our pipeline</a> </li> <li class="pipeline-tabs__item" data-target="pipeline-changes" role="presentation"> <a class="pipeline-tabs__button" title="Pipeline changes" href="#pipeline-changes" role="tab" id="pipeline-changes-tab" aria-controls="pipeline-changes" aria-selected="false">Pipeline changes</a> </li> </ul> <ul class="pipeline-options"> <li class="pipeline-options__item" data-option="key"> <button class="pipeline-options__button" aria-label="Open Popup"> <div class="pipeline-options__button-wrapper"> <svg class="icon-circle-info"> <use xlink:href="/assets/img/icon-sprite.svg#icon-circle-info" /> </svg> <span>Key</span> <svg class="icon-plus"> <use xlink:href="/assets/img/icon-sprite.svg#icon-plus" /> </svg> </div> </button> </li> </ul> <div data-pipeline="desktop-search"></div> <form id="pipeline-search" class="form-search"> <div class="pipeline-search"> <input class="pipeline-search__input" type="text" data-pipeline="search-input" placeholder="Enter compound number or name"> <button type="submit" class="button" data-pipeline="search-button" aria-label="Search"> <div> <svg> <use xlink:href="/assets/img/icon-sprite.svg#icon-search"></use> </svg> </div> </button> </div> </form> <!-- Desktop Key --> <div class="pipeline-key"> <div class="pipeline-key__content"> <button class="pipeline-key__content-close" aria-label="Close Popup"> <svg class="icon-close"> <use xlink:href="/assets/img/icon-sprite.svg#icon-close" /> </svg> </button> <h2 class="pipeline-key__title">Key</h2> <dl class="pipeline-key__list"> <dt class="pipeline-key__term">†</dt> <dd class="pipeline-key__definition">In-license or other alliance relationship with third party</dd> <dt class="pipeline-key__term">^</dt> <dd class="pipeline-key__definition">ViiV Healthcare, a global specialist HIV company with GSK, Pfizer, Inc. and Shionogi Limited as shareholders, is responsible for developing and delivering HIV medicines.</dd> <dt class="pipeline-key__term">*</dt> <dd class="pipeline-key__definition">In Phase I/II study</dd> <dt class="pipeline-key__term">#</dt> <dd class="pipeline-key__definition">In Phase II/III study</dd> <dt class="pipeline-key__term">1</dt> <dd class="pipeline-key__definition">Approved in US and EU</dd> <dt class="pipeline-key__term">2</dt> <dd class="pipeline-key__definition">Non-registrational</dd> <dt class="pipeline-key__term">3</dt> <dd class="pipeline-key__definition">Phase II study start expected in 2025</dd> <dt class="pipeline-key__term">4</dt> <dd class="pipeline-key__definition">GSK has an exclusive global license option to co-develop and commercialize the candidate</dd> <dt class="pipeline-key__term">5</dt> <dd class="pipeline-key__definition">Phase I study start imminent </dd> <dt class="pipeline-key__term">6</dt> <dd class="pipeline-key__definition">Approved in US</dd> </dl> </div> </div> </div> <div class="pipeline-tabs__content-wrapper"> <div class="pipeline-tabs__content pipeline-tabs__content--active" role="tabpanel" id="our-pipeline" aria-labelledby="our-pipeline-tab" data-content="our-pipeline"> <div class="pipeline-info"> <h3 class="pipeline-info__title">Pipeline updated 30 October 2024</h3> <ul class="pipeline-info__options pipeline-options"> <li class="pipeline-options__item" data-option="filter"> <button class="pipeline-options__button" > <div class="pipeline-options__button-wrapper"> <svg class="icon-circle-info"> <use xlink:href="/assets/img/icon-sprite.svg#icon-circle-info" /> </svg> Filter </div> </button> </li> <li class="pipeline-options__item" data-option="key"> <button class="pipeline-options__button"> <div class="pipeline-options__button-wrapper"> <svg class="icon-circle-info"> <use xlink:href="/assets/img/icon-sprite.svg#icon-circle-info" /> </svg> Key </div> </button> </li> </ul> <div data-pipeline="mobile-search" class="pipeline-search-mobile"></div> <ul class="pipeline-info__key pipeline-icon-key"> <li class="pipeline-icon-key__icon"> <div class="icon icon-additional-information" tabindex="0"></div> Immuno-modulator </li> </ul> </div> <div class="pipeline-key"> <div class="pipeline-key__content"> <button class="pipeline-key__content-close" aria-label="Close Popup"> <svg class="icon-close"> <use xlink:href="/assets/img/icon-sprite.svg#icon-close" /> </svg> </button> <h2 class="pipeline-key__title">Key</h2> <dl class="pipeline-key__list"> <dt class="pipeline-key__term">†</dt> <dd class="pipeline-key__definition">In-license or other alliance relationship with third party</dd> <dt class="pipeline-key__term">^</dt> <dd class="pipeline-key__definition">ViiV Healthcare, a global specialist HIV company with GSK, Pfizer, Inc. and Shionogi Limited as shareholders, is responsible for developing and delivering HIV medicines.</dd> <dt class="pipeline-key__term">*</dt> <dd class="pipeline-key__definition">In Phase I/II study</dd> <dt class="pipeline-key__term">#</dt> <dd class="pipeline-key__definition">In Phase II/III study</dd> <dt class="pipeline-key__term">1</dt> <dd class="pipeline-key__definition">Approved in US and EU</dd> <dt class="pipeline-key__term">2</dt> <dd class="pipeline-key__definition">Non-registrational</dd> <dt class="pipeline-key__term">3</dt> <dd class="pipeline-key__definition">Phase II study start expected in 2025</dd> <dt class="pipeline-key__term">4</dt> <dd class="pipeline-key__definition">GSK has an exclusive global license option to co-develop and commercialize the candidate</dd> <dt class="pipeline-key__term">5</dt> <dd class="pipeline-key__definition">Phase I study start imminent </dd> <dt class="pipeline-key__term">6</dt> <dd class="pipeline-key__definition">Approved in US</dd> </dl> </div> </div> <div class="pipeline" data-sidebar="false" data-sidebar-therapy-area="" data-endpoint="/umbraco/api/pipeline/getcompounds"> <div class="pipeline__filters js-filter-template" data-pipeline="sidebar-filters"></div> <div class="pipeline__table js-datatable-template" data-table-type="our-pipeline"></div> </div> </div> <div class="pipeline-tabs__content" role="tabpanel" id="pipeline-changes" aria-labelledby="pipeline-changes-tab" data-content="pipeline-changes"> <div class="pipeline-info" id="pipeline-changes-info"> <h3 class="pipeline-info__title">&nbsp;</h3> <ul class="pipeline-info__options pipeline-options"> <li class="pipeline-options__item" data-option="filter" style="opacity: 0; pointer-events: none;"> <button class="pipeline-options__button"> <div class="pipeline-options__button-wrapper"> <svg 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with GSK, Pfizer, Inc. and Shionogi Limited as shareholders, is responsible for developing and delivering HIV medicines.</dd> <dt class="pipeline-key__term">*</dt> <dd class="pipeline-key__definition">In Phase I/II study</dd> <dt class="pipeline-key__term">#</dt> <dd class="pipeline-key__definition">In Phase II/III study</dd> <dt class="pipeline-key__term">1</dt> <dd class="pipeline-key__definition">Approved in US and EU</dd> <dt class="pipeline-key__term">2</dt> <dd class="pipeline-key__definition">Non-registrational</dd> <dt class="pipeline-key__term">3</dt> <dd class="pipeline-key__definition">Phase II study start expected in 2025</dd> <dt class="pipeline-key__term">4</dt> <dd class="pipeline-key__definition">GSK has an exclusive global license option to co-develop and commercialize the candidate</dd> <dt class="pipeline-key__term">5</dt> <dd class="pipeline-key__definition">Phase I study start imminent </dd> <dt class="pipeline-key__term">6</dt> <dd class="pipeline-key__definition">Approved in US</dd> </dl> </div> </div> <ul class="pipeline-info__key pipeline-icon-key"> <li class="pipeline-icon-key__icon"> <div class="icon icon-additional-information" tabindex="0"></div> Immuno-modulator </li> </ul> </div> <div class="pipeline" data-sidebar="false" data-sidebar-therapy-area="" data-endpoint="/umbraco/api/pipeline/getcompounds"> <div class="pipeline__filters pipeline__filters--readonly js-filter-template"></div> <div class="pipeline__table js-datatable-template" data-table-type="pipeline-changes"></div> </div> <div class="pipeline-search__no-results" data-pipeline="no-results"> <p>No results - Please try with another term</p> </div> </div> </div> </div> </div> </div> <script id="phasesFilterTemplate" type="handlebars/template"> <ul class="filter-phase__list"> <li class="filter-phase__item filter-phase__item--all"> <label class="filter-phase__item-label"> <input class="filter-phase__item-checkbox-hidden" type="checkbox" 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class="filter-phase__trigger-close">Close x</span> <ul class="filter-phase__list"> <li class="filter-phase__item filter-phase__item--all"> <label class="filter-phase__item-label"> <input class="filter-phase__item-checkbox-hidden" type="checkbox" checked="checked" value=""> <div class="filter-phase__item-checkbox"></div> <span class="filter-phase__item-text">View all phases</span> </label> </li> {{#each Phases as |Phase|}} <li class="filter-phase__item filter-phase__item--control filter-phase__item--inactive"> <label class="filter-phase__item-label"> <input class="filter-phase__item-checkbox-hidden" type="checkbox" value="{{ Phase }}"> <div class="filter-phase__item-checkbox"></div> <span class="filter-phase__item-text">{{ Phase }}</span> </label> </li> {{/each}} </ul> <button class="filter-phase__clear">Clear</button> </div> </th> <th class="compounds-table__cell" data-column="Mode of Action"> Mode of action /<br> Vaccine type </th> </tr> </thead> <tbody class="compounds-table__body"> 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class="compounds-table__cell" data-column="Phase">Phase</th>{{/ifNot}} {{#ifEquals Change.Heading 'Removed'}} <th class="compounds-table__cell" data-column="Reason">Notes</th>{{/ifEquals}} <th class="compounds-table__cell" data-column="Notes">Notes</th> </tr> </thead> <tbody class="compounds-table__body"> {{#each Change.Compounds as |Compound|}} {{ Compoud }} <tr class="compounds-table__row" data-compound-index="{{ @index }}"> <td class="compounds-table__cell" data-therapy-area="{{ Compound.TherapyArea.Colour }}" style="border-left-color: {{ Compound.TherapyArea.Colour }}" data-column="Name"> <p class="compounds-table__cell-text">{{ Compound.CompoundId }}</p> <span style="display: none">{{ Compound.CompoundId }} {{#if Compound.GenericName}}{{ Compound.GenericName }}{{/if}} {{#if Compound.BrandName}}{{ Compound.BrandName }}{{/if}}</span> {{#if Compound.GenericName}}<p class="compounds-table__cell-text">{{ Compound.GenericName }}</p>{{/if}} {{#if Compound.BrandName}}<p 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data-column="Reason">{{ Compound.Reason }}</td> {{/ifEquals}} <td class="compounds-table__cell" data-column="Notes">{{ Compound.Notes }}</td> </tr> {{/each}} </tbody> </table> </div> {{/each}} </script> <script id="mobileSidebarTemplate" type="handlebars/template"> <div class="pipeline-sidebar"> <button class="pipeline-sidebar__close"></button> <div class="pipeline-sidebar__body"> <div class="pipeline-sidebar__header"> <h1 class="pipeline-sidebar__header-title">Filters</h1> <p class="pipeline-sidebar__description">Click below to filter by therapeutic area</p> </div> <div class="pipeline-sidebar__filters"> <div class="pipeline__filters js-filter-template"></div> </div> <div class="pipeline-sidebar__phase-filters"> <p class="pipeline-sidebar__description">Click below to filter by phase</p> <div class="filter-phase js-filter-phase"></div> </div> <div class="pipeline-sidebar__footer"> <button class="filters__clear-all">Clear filters</button> </div> </div> </div> </script> <div class="main-container rte "> <div class="content-wrapper"> <h2 data-renderer-start-pos="851">Pipeline progress</h2> <p data-renderer-start-pos="1056">The content of our development pipeline will change over time as new projects progress from research to development and from development to the market.</p> </div> </div> <div class="main-container rte "> <div class="content-wrapper"> <h2>Phases of clinical development</h2> <p>Our products in development progress through three stages: <strong data-renderer-mark="true">phase I</strong>, <strong data-renderer-mark="true">phase II</strong> and <strong data-renderer-mark="true">phase III/registrational</strong>. Each of these phases allows us to assess the safety and efficacy of our investigational products to eventually provide data to support applications for regulatory approval. For competitive reasons, new projects in pre-clinical development are not disclosed and some project types may not be identified.</p> <p> </p> </div> </div> <div class="main-container"> <div class="accordion" id="1"> <div class="accordion__toggle"> <button href="#" class="accordion__toggle-button" data-is-open="false" data-expand-label="Expand all" data-collapse-label="Close All" aria-label=""> Expand all </button> <br /> </div> <div class="accordion__header" data-category="heading1-1"> <h3 class="accordion__title"> <button type="button" aria-controls="content1-1"> Phase I </button> </h3> </div> <div class="accordion__content" id="content1-1"> <div class="rte"> <p>This is the first time a new vaccine or medicine is tested in humans; it will usually be given to a small group of healthy volunteers, or it may be tested on patients who have the condition it is designed to treat. The principle objectives in phase I are to ensure the new vaccine or medicine presents no major safety issues, and to see clear evidence that it can reach the targeted body area and remain there long enough to deliver its potential benefits. We also seek to gain preliminary evidence the vaccine or medicine can offer therapeutic value or help to prevent the disease in question.  </p> </div> <a href="#" class="accordion__top-link"><span>Back to top</span></a> </div> <div class="accordion__header" data-category="heading1-2"> <h3 class="accordion__title"> <button type="button" aria-controls="content1-2"> Phase II </button> </h3> </div> <div class="accordion__content" id="content1-2"> <div class="rte"> <p>At this stage, the potential vaccine or medicine is usually tested to understand the effectiveness against the disease it is designed to treat and appropriate dosing levels. The performance of the medicine in one group of patients may be compared against another group of patients receiving a placebo (a treatment that looks the same as the potential new medicine, but has no active ingredients) or an existing treatment.</p> </div> <a href="#" class="accordion__top-link"><span>Back to top</span></a> </div> <div class="accordion__header" data-category="heading1-3"> <h3 class="accordion__title"> <button type="button" aria-controls="content1-3"> Phase III/registrational </button> </h3> </div> <div class="accordion__content" id="content1-3"> <div class="rte"> <p>This phase consists of a much larger and potentially longer trial, often involving hundreds or possibly thousands of participants from a range of different countries. The principle objectives in phase III are to demonstrate the safety and effectiveness of the new vaccine or medicine in the typical patient likely to use it; confirm effective dosing levels; identify contraindications; build knowledge of the benefits of the vaccine or medicine and compare them with any risks; and compare results against any currently achieved by existing treatments. Regulators will determine how a new product should be used, and which patients should qualify for it based on all the evidence from clinical and pre-clinical studies.</p> </div> <a href="#" class="accordion__top-link"><span>Back to top</span></a> </div> <div class="accordion__header" data-category="heading1-4"> <h3 class="accordion__title"> <button type="button" aria-controls="content1-4"> Monitoring post-launch </button> </h3> </div> <div class="accordion__content" id="content1-4"> <div class="rte"> <p>Monitoring is overseen by our Global Safety Board (GSB), which is chaired by our chief medical officer and made up of senior physicians and scientists. Part of its remit is to review the information on the safety of our products as reports come in from patients and prescribers on the use of the medicines. All the board's decisions are guided by the need to ensure that the benefits of our vaccines and medicines always outweigh any risks. We continue to monitor patients' responses to our medicines through reports and regulator reporting systems. We follow this information to fully understand a new vaccine or medicine's effectiveness. We also look for any adverse effects that may only become apparent as more patients use a treatment.</p> </div> <a href="#" class="accordion__top-link"><span>Back to top</span></a> </div> </div> </div> <div class="main-container rte "> <div class="content-wrapper"> <p><em>Brand names are trademarks either owned by and/or licensed to GSK or associated companies. </em>  <em>For COVID-19 vaccines, GSK is contributing pandemic adjuvant to COVID-19 vaccines collaborations.</em> <em>This information was updated on<strong> 30 October 2024</strong>. </em> </p> </div> </div> <div class="spacer"> <div class="main-container"> <p></p> </div> </div> <div class="main-container main-container--module-row"> <div class="content-wrapper"> <h2>You might also like</h2> </div> <div class="grid"> <div class="grid-cell tablet-span-4"> <div class="grid-promo-box"> <a href="/en-gb/behind-the-science-magazine/"> <div class="grid-promo-box__img"> <img src="/media/11381/vaccine-manufacturing-production-line-2.jpg?anchor=center&amp;mode=crop&amp;quality=90&amp;width=427&amp;height=533&amp;rnd=133645644710000000" loading="lazy" alt="Scientist works in a futurist vaccine laboratory for GSK" /> </div> <div class="grid-promo-box__content"> <h3>Behind the science magazine</h3> <p>Explore innovations from inside and outside our labs. 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