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effect</title> <meta name="description" content="Search results for: hypoglycemic effect"> <meta name="keywords" content="hypoglycemic effect"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="hypoglycemic effect"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 14771</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: hypoglycemic effect</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14771</span> Effect of Ginger (Zingiber Officinal) Root Extract on Blood Glucose Level and Lipid Profile in Normal and Alloxan-Diabetic Rabbits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khalil%20Abdullah%20Ahmed%20Khalil">Khalil Abdullah Ahmed Khalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsadig%20Mohamed%20Ahmed"> Elsadig Mohamed Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ginger is one of the most important medicinal plants, which is widely used in folk medicine. This study was designed to go further step and evaluate the hypoglycemic and hypolipidaemic effects of the aqueous ginger root extract in normal and alloxan diabetic rabbits. Results revealed that the aqueous ginger has a significant hypoglycemic effect (P<0.05) in diabetic rabbits but a non-significant hypoglycemic effect (P>0.05) in normal rabbits. There were also significant decreases in the concentrations (P<0.05) in serum cholesterol, triglycerides and LDL – cholesterol in both normal and diabetic rabbits. Although there was an elevation in serum HDL- cholesterol in both normal and diabetic rabbits, these elevations were non-significant (P>0.05). Our data suggest the aqueous ginger has a hypoglycemic effect in diabetic rabbits and lipid-lowering properties in both normal and diabetic rabbits. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract%20of%20ginger%20root%20%28AEGR%29" title="aqueous extract of ginger root (AEGR)">aqueous extract of ginger root (AEGR)</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic" title=" hypoglycemic"> hypoglycemic</a>, <a href="https://publications.waset.org/abstracts/search?q=cholesterol" title=" cholesterol"> cholesterol</a>, <a href="https://publications.waset.org/abstracts/search?q=triglyceride" title=" triglyceride"> triglyceride</a> </p> <a href="https://publications.waset.org/abstracts/142726/effect-of-ginger-zingiber-officinal-root-extract-on-blood-glucose-level-and-lipid-profile-in-normal-and-alloxan-diabetic-rabbits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142726.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">293</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14770</span> Assessment of the Neuroprotective Effect of Oral Hypoglycemic Agents in Patients with Acute Ischemic Stroke</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Alhusban">A. Alhusban</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Alqawasmeh"> M. Alqawasmeh</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Alfawares"> F. Alfawares</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Diabetes is a chronic health problem and a major risk factor of stroke. A number of therapeutic modalities exist for diabetes management. It’s still unknown whether the different oral hypoglycemic agents would ameliorate the detrimental effect of diabetes on stroke severity. The objective of this work is to assess the effect of pretreatment with oral hypoglycemic agents, insulin and their combination on stroke severity at presentation. Patients and Methods: Patients admitted to the King Abdullah University Hospital (KAUH)-Jordan with ischemic stroke between January 2015 and December 2016 were evaluated and their comorbid diseases, treatment on admission and their neurologic severity was assessed using the National Institute of Health Stroke Scale (NIHSS) were documented. Stroke severity was compared for non-diabetic patients and diabetic patients treated with different antidiabetic agents. Results: Data from 324 patients with acute stroke was documented. The median age of participants was 69 years. Diabetes was documented in about 50% of the patients. Multinomial regression analysis identified diabetes treatment status as an independent predictor of neurological severity of stroke (p=0.032). Patients treated with oral hypoglycemic agents had a significantly lower NIHSS as compared to nondiabetic patients and insulin treated patients (p < 0.02). The positive effect of oral hypoglycemic agents was blunted by insulin co-treatment. Insulin did not alter the severity of stroke as compared to non-diabetics. Conclusion: Oral hypoglycemic agents may reduce the severity of neurologic deficit of ischemic stroke and may have neuroprotective effect. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=stroke" title=" stroke"> stroke</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroprotection" title=" neuroprotection"> neuroprotection</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20hypoglycemic%20agents" title=" oral hypoglycemic agents"> oral hypoglycemic agents</a> </p> <a href="https://publications.waset.org/abstracts/100618/assessment-of-the-neuroprotective-effect-of-oral-hypoglycemic-agents-in-patients-with-acute-ischemic-stroke" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100618.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">164</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14769</span> Hypoglycemic Effect of Flavonoids from the Leaves of Olea europaea L. in Normal and Alloxan Induced Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Benhabyles">N. Benhabyles</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Arab"> K. Arab</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Bouchenak"> O. Bouchenak</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Baz"> A. Baz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The hypoglycemic and antihyperglycemic effects of flavonoids rich extract obtained from leaves of Olea europaea L. was analyzed in normal and alloxan induced diabetic rats. The extraction was performed by confrontation with organic solvents method, which yielded four extracts: Di ethyl Ether, Ethyl Acetate, Butanolic, and Aqueous extract. A single oral dose of 100 mg/kg of the different extract was evaluated for hypoglycemic activity in a glucose tolerance test in normal rats and 200 mg/kg, 400 mg/kg, 600 mg/kg of AE for anti-hyperglycemic activity in alloxan-induced (125 mg/kg) diabetic rats. Dosage of 100 mg/kg of the extract significantly decreased (p<0.05) blood glucose levels in the glucose tolerance test after 120 min. However, a better activity is obtained with the AE. For the anti-hyperglycemic study, the results showed a substantial decrease in blood glucose during the 2 h of treatment for all groups treated with different doses of flavonoids. From the results it can be concluded that flavonoids of O. europaea can be a potential candidate in treating the hyperglycemic conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alloxan" title="alloxan">alloxan</a>, <a href="https://publications.waset.org/abstracts/search?q=antihyperglycemic%20effect" title=" antihyperglycemic effect"> antihyperglycemic effect</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20effect" title=" hypoglycemic effect"> hypoglycemic effect</a>, <a href="https://publications.waset.org/abstracts/search?q=Olea%20europaea%20L." title=" Olea europaea L."> Olea europaea L.</a> </p> <a href="https://publications.waset.org/abstracts/12946/hypoglycemic-effect-of-flavonoids-from-the-leaves-of-olea-europaea-l-in-normal-and-alloxan-induced-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12946.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">373</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14768</span> The Possible Antioxidant, Hypoglycemic Effect and Antimicrobial Potential of Mangifera Indicia Leaves Aqueous Extract in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sahar%20B.%20Ahmed">Sahar B. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mostafa%20Said"> M. Mostafa Said</a>, <a href="https://publications.waset.org/abstracts/search?q=Mona%20I.%20Mohamed"> Mona I. Mohamed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Streptozotocin (STZ) caused a significant increase in blood glucose and malondialdehyde (MDA) levels in serum accompanied by a significant decrease in blood reduced glutathione (GSH) and superoxide dismutase (SOD) activities. Also, ALT, AST, albumin and urea were markedly affected by STZ injection. The oral administration of Mango leaves extract (MLE) one hour before STZ injection was significantly improved the blood glucose level, ALT, AST activities, albumin and urea that associated with the regulation of MDA, GSH and SOD levels. The antimicrobial activity of MLE showed a significant inhibitory activity against multidrug resistant gram positive and gram negative bacteria isolated from patients in Egyptian hospitals especially Salmonella typhi and typhimurium. In conclusion, results revealed the antioxidant, hypoglycemic effect and antimicrobial potentials of MLE under investigation. Further studies will be needed to investigate the prolonged period of MLE administration and its possible side effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract%20of%20mango%20leaves" title="aqueous extract of mango leaves">aqueous extract of mango leaves</a>, <a href="https://publications.waset.org/abstracts/search?q=STZ" title=" STZ"> STZ</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20effect" title=" hypoglycemic effect"> hypoglycemic effect</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20potentials." title=" antimicrobial potentials."> antimicrobial potentials.</a> </p> <a href="https://publications.waset.org/abstracts/8510/the-possible-antioxidant-hypoglycemic-effect-and-antimicrobial-potential-of-mangifera-indicia-leaves-aqueous-extract-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8510.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14767</span> Comparison of the Effects of Fresh Leaf, Septum and Peel Extracts of Walnut on Blood Glucose and Pancreatic Structure</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tahmineh%20Hasanzadeh">Tahmineh Hasanzadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Afshin%20Farahbakhsh"> Afshin Farahbakhsh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> There is some report about the hypoglycemic effect of Juglans rejia L. leaf in alloxan induced diabetic rats and hypoglycemic effect of its fruit peel administered intraperitoneally.In Iranian traditional medicine, septum of walnut shell (SWS) was recommended to reduce blood glucose. For this purpose, 41 male bulb/C mice 25-30 gm were divided into five groups. All the animals received IP injection of streptozotocin (STZ) (220 mg/kg). Two weeks later, the diabetic animals were received daily oral treatment of normal saline and aqueous extract of SWS (200, 400, 600 and 800 mg/kg) respectively for four weeks. Blood samples were taken from retro orbital sinus before the start of the experiment and repeated each two weeks. At the end of the experiment, the animals were sacrificed and the pancreatic tissues were fixed, prepared and stained by Hematoxylin-Eosin for light microscope studies. The results showed that in each group, the SWS extract reduced blood glucose in a long time (p < 0.05). metabolic extract in STZ- induced diabetic rats, which was accompanied by the hypoglycemic effect of leaf extract. However, this effect should be determined with scientific researches. Therefore, the aim of this study is to evaluate the effect of the aqueous extract of SWS on blood glucose and histopathological structure of pancreas. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=septum%20of%20walnut" title="septum of walnut">septum of walnut</a>, <a href="https://publications.waset.org/abstracts/search?q=blood%20glucose" title=" blood glucose"> blood glucose</a>, <a href="https://publications.waset.org/abstracts/search?q=pancreas" title=" pancreas"> pancreas</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=walnut%20leaf" title=" walnut leaf"> walnut leaf</a>, <a href="https://publications.waset.org/abstracts/search?q=walnut%20peel" title=" walnut peel"> walnut peel</a>, <a href="https://publications.waset.org/abstracts/search?q=insulin" title=" insulin"> insulin</a> </p> <a href="https://publications.waset.org/abstracts/46409/comparison-of-the-effects-of-fresh-leaf-septum-and-peel-extracts-of-walnut-on-blood-glucose-and-pancreatic-structure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46409.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">279</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14766</span> Consumer Acceptability of Crackers Produced from Blend of Sprouted Pigeon Pea, Unripe Plantain and Brewers’ Spent Grain and Its Hypoglycemic Effect in Diabetic Rats </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nneka%20N.%20Uchegbu">Nneka N. Uchegbu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Physical, sensory properties and hypoglycemic effect of crackers produced from sprouted pigeon pea, unripe plantain and brewers’ spent grain fed to diabetic rats were investigated. Different composite flours were used to produce crackers. Physical and sensory properties of the crackers, the blood serum of the rats and changes in the rat body weight were measured. Spread ratio and break strength of the crackers from different flour blends ranges from 7.01 g to 8.51 g and 1.87 g to 3.01 g respectively. The acceptability of the crackers revealed that Sample A (100% wheat crackers) was not significantly (p>0.05) different from Samples C and D. Feeding the rats with formulated crackers caused an increase in the body weight of the rats but a reduced body weight was observed in diabetic rats fed with normal rat feed. The result indicated that cracker produced from the formulated flour blends caused a significant hypoglycemic effect in diabetic rats and led to a reduction of measured biochemical indices. Therefore, this work showed that consumption of crackers from the above formulated flour blend was able to decrease hyperglycemia in diabetic rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hypoglyceamia" title="hypoglyceamia">hypoglyceamia</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperlipidimia" title=" hyperlipidimia"> hyperlipidimia</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20lipid" title=" total lipid"> total lipid</a>, <a href="https://publications.waset.org/abstracts/search?q=triglyceride" title=" triglyceride"> triglyceride</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20cholesterol" title=" total cholesterol"> total cholesterol</a> </p> <a href="https://publications.waset.org/abstracts/50049/consumer-acceptability-of-crackers-produced-from-blend-of-sprouted-pigeon-pea-unripe-plantain-and-brewers-spent-grain-and-its-hypoglycemic-effect-in-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50049.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">301</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14765</span> Quercetin Nanoparticles and Their Hypoglycemic Effect in a CD1 Mouse Model with Type 2 Diabetes Induced by Streptozotocin and a High-Fat and High-Sugar Diet</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adriana%20Garcia-Gurrola">Adriana Garcia-Gurrola</a>, <a href="https://publications.waset.org/abstracts/search?q=Carlos%20Adrian%20Pe%C3%B1a%20Natividad"> Carlos Adrian Peña Natividad</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Laura%20Martinez%20Martinez"> Ana Laura Martinez Martinez</a>, <a href="https://publications.waset.org/abstracts/search?q=Alberto%20Abraham%20Escobar%20Puentes"> Alberto Abraham Escobar Puentes</a>, <a href="https://publications.waset.org/abstracts/search?q=Estefania%20Ochoa%20Ruiz"> Estefania Ochoa Ruiz</a>, <a href="https://publications.waset.org/abstracts/search?q=Aracely%20Serrano%20Medina"> Aracely Serrano Medina</a>, <a href="https://publications.waset.org/abstracts/search?q=Abraham%20Wall%20Medrano"> Abraham Wall Medrano</a>, <a href="https://publications.waset.org/abstracts/search?q=Simon%20Yobanny%20Reyes%20Lopez"> Simon Yobanny Reyes Lopez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by elevated blood glucose levels. Quercetin is a natural flavonoid with a hypoglycemic effect, but reported data are inconsistent due mainly to the structural instability and low solubility of quercetin. Nanoencapsulation is a distinct strategy to overcome the intrinsic limitations of quercetin. Therefore, this work aims to develop a quercetin nano-formulation based on biopolymeric starch nanoparticles to enhance the release and hypoglycemic effect of quercetin in T2DM induced mice model. Starch-quercetin nanoparticles were synthesized using high-intensity ultrasonication, and structural and colloidal properties were determined by FTIR and DLS. For in vivo studies, CD1 male mice (n=25) were divided into five groups (n=5). T2DM was induced using a high-fat and high-sugar diet for 32 weeks and streptozotocin injection. Group 1 consisted of healthy mice fed with a normal diet and water ad libitum; Group 2 were diabetic mice treated with saline solution; Group 3 were diabetic mice treated with glibenclamide; Group 4 were diabetic mice treated with empty nanoparticles; and Group 5 was diabetic mice treated with quercetin nanoparticles. Quercetin nanoparticles had a hydrodynamic size of 232 ± 88.45 nm, a PDI of 0.310 ± 0.04 and a zeta potential of -4 ± 0.85 mV. The encapsulation efficiency of nanoparticles was 58 ± 3.33 %. No significant differences (p = > 0.05) were observed in biochemical parameters (lipids, insulin, and peptide C). Groups 3 and 5 showed a similar hypoglycemic effect, but quercetin nanoparticles showed a longer-lasting effect. Histopathological studies reveal that T2DM mice groups showed degenerated and fatty liver tissue; however, a treated group with quercetin nanoparticles showed liver tissue like that of the healthy mice group. These results demonstrate that quercetin nano-formulations based on starch nanoparticles are effective alternatives with hypoglycemic effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=quercetin" title="quercetin">quercetin</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus%20tipo%202" title=" diabetes mellitus tipo 2"> diabetes mellitus tipo 2</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo%20study" title=" in vivo study"> in vivo study</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/188958/quercetin-nanoparticles-and-their-hypoglycemic-effect-in-a-cd1-mouse-model-with-type-2-diabetes-induced-by-streptozotocin-and-a-high-fat-and-high-sugar-diet" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188958.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">34</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14764</span> Hypoglycemic Coma in Elderly Patients with Diabetes mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20Furuya">D. Furuya</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Ryujin"> H. Ryujin</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Takahira"> S. Takahira</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Sekine"> Y. Sekine</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Oya"> Y. Oya</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Sonoda"> K. Sonoda</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Ogawa"> H. Ogawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Nomura"> Y. Nomura</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Maruyama"> R. Maruyama</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Kim"> H. Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Kudo"> T. Kudo</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Nakano"> A. Nakano</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Saruta"> T. Saruta</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Sugita"> S. Sugita</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Nemoto"> M. Nemoto</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Tanahashi"> N. Tanahashi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: To study the clinical characteristics of hypoglycemic coma in adult patients with type 1 or type 2 diabetes mellitus (DM). Methods: Participants in this retrospective study comprised 91 patients (54 men, 37 women; mean age ± standard deviation, 71.5 ± 12.6 years; range, 42-97 years) brought to our emergency department by ambulance with disturbance of consciousness in the 7 years from April 2007 to March 2014. Patients with hypoglycemia caused by alcoholic ketoacidosis, nutrition disorder, malignancies and psychological disorder were excluded. Results: Patients with type 1 (8 of 91) or type 2 DM (83 of 91) were analyzed. Mean blood sugar level was 31.6 ± 10.4 in all patients. A sulfonylurea (SU) was more commonly used in elderly (>75 years old; n=44)(70.5%) than in younger patients (36.2%, p < 0.05). Cases showing prolonged unconsciousness (range, 1 hour to 21 days; n=30) included many (p < 0.05) patients with dementia (13.3%; 0.5% without dementia) and fewer (p < 0.05) patients with type 1 DM (0%; 13.1% in type 2 DM). Specialists for DM (n=33) used SU less often (24.2%) than general physicians (69.0%, p < 0.05). Conclusion: In cases of hypoglycemic coma, SU was frequently used in elderly patients with DM. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20coma" title="hypoglycemic coma">hypoglycemic coma</a>, <a href="https://publications.waset.org/abstracts/search?q=Diabetes%20mellitus" title=" Diabetes mellitus"> Diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=unconsciousness" title=" unconsciousness"> unconsciousness</a>, <a href="https://publications.waset.org/abstracts/search?q=elderly%20patients" title=" elderly patients"> elderly patients</a> </p> <a href="https://publications.waset.org/abstracts/20274/hypoglycemic-coma-in-elderly-patients-with-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20274.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">490</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14763</span> Hypoglycemic Activity studies on Root Extracts of Sanseviera liberica Root in Streptozotocin-Induced Diabetic Rats </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Omowunmi%20Amao">Omowunmi Amao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sansevieria liberica belongs to the family Agavaceae (Ruscaceae or Dracaenaceae). They are widely distributed throughout the tropics. Literature review suggests that in Nigeria, the leaves and roots of Sansevieria liberica are used in traditional medicine for the treatment of asthma, abdominal pains, colic, diarrhea, eczema, gonorrhea, hemorrhoids, hypertension, monorrhagia, piles, sexual weakness, snake bites, and wounds of the foot. In this context, the standardized Methanolic extract of roots of Sansevieria liberica is hypothesized for the evaluation of the hypoglycemic activity. Material and Methods: Inbreed adult male sprague-Dawley albino rats were used in the experiment. The suspension of standardized Methanol extract (ME) of Sansevieria liberica was treated for hypoglycemic activity in oral glucose tolerance test (OGTT) method. The suspension of standardized Methanolic extract (ME) of Sansevieria liberica was also treated for hypoglycemic activity in streptozotocin-induced diabetic rats. Results: The Methanolic extract (ME) of Sanseviera liberica root (100 mg/kg, 200mg/kg, and 400 mg/kg) showed potential hypoglycemic activity in diabetic rats, and further in OGTT method. Furthermore, Methanolic extract of Sanseviera liberica root showed significant (P<0.05) increase in final body weight, total hemoglobin, insulin, albumin and high-density lipoprotein levels, however, decrease in fluid intake, glycosylated hemoglobin, urea, creatinine, total cholesterol, triglyceride and low-density lipoprotein levels. Additionally, it improved oxidative stress in terms of reducing lipid peroxidase and superoxide dismutase, and elevating catalase activity. Conclusions: These findings suggest that the Methanolic extract of Sanseviera liberica root was found to be potential hypoglycemic, and would be a promising candidate for the treatment of diabetes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanseviera%20liberica" title=" Sanseviera liberica"> Sanseviera liberica</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20activity" title=" hypoglycemic activity"> hypoglycemic activity</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20and%20metabolism" title=" diabetes and metabolism"> diabetes and metabolism</a> </p> <a href="https://publications.waset.org/abstracts/18206/hypoglycemic-activity-studies-on-root-extracts-of-sanseviera-liberica-root-in-streptozotocin-induced-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18206.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14762</span> The Role of Polyphenolic Compounds in the Alpha Amylase and Alpha Glucosidase Inhibitory Potentials of Extracts from the Leaves of Acalypha godseffiana from Eastern Nigeria: An in-vitro Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20K.%20Asekunowo">A. K. Asekunowo</a>, <a href="https://publications.waset.org/abstracts/search?q=A%20O.%20T.%20Asafa"> A O. T. Asafa</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20O.%20Okoh"> O. O. Okoh</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20T.%20Asekun"> O. T. Asekun</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20B.%20Familoni"> O. B. Familoni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Acalypha godseffiana is an important plant used both as an ornamental and herbs; its leaves are employed in management of diseases such as diabetics in Eastern Nigeria. Aim: The correlations of the polyphenolic compounds in the hypoglycemic potential of different extracts of leaves of A. godseffiana and their safety profile on cell lines were investigated. Materials and Methods: The phytochemical compositions and antioxidants potentials were determined using adopted methods. An in vitro approach was employed in determining the hypoglycemic potentials of the extracts on α-amylase and α-glucosidase. The Line weaver-Burke plot was used to evaluate the mechanisms of Inhibition mechanisms of the enzymes. Results and Conclusions: Antioxidants results revealed that total antioxidant capacity (TAC) of the acetone extract (IC50: 0.34 mg/mL) showed better activity compared to the standards (silymarine 0.52 mg/mL; gallic acid 0.51 mg/mL). In-vitro hypoglycemic activity of the extracts confirmed that acetone extract demonstrated strong and mild inhibitory potential against α-amylase and α-glucosidase respectively. The observed activity was concentration-dependent with IC50 values of 2.33 and 0.13 mg/mL. The observed hypoglycemic and anti-oxidant potentials of acetone extract A. godseffiana correlate to its high polyphenolic contents which include phenols (133.20 mg gallic acid g-1), flavonoid (350.60 mg quercetin g-1) and tannins (264.67 mg catechin g-1). The mechanisms of action exhibited by acetone extract of A. godseffiana were mixed non-competitive and uncompetitive; which can be attributed to its inhibitory properties on α-amylase and α-glucosidase respectively. This effect would cause reduction in the rate at which starch hydrolyse, boost palliated glucose levels; hence, making acetone extract of A. godseffiana a potential anti-hypoglycemic alternative. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Acalypha%20godeseffiana" title="Acalypha godeseffiana">Acalypha godeseffiana</a>, <a href="https://publications.waset.org/abstracts/search?q=acetone%20extract" title=" acetone extract"> acetone extract</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-hypoglycemia" title=" anti-hypoglycemia"> anti-hypoglycemia</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a> </p> <a href="https://publications.waset.org/abstracts/61511/the-role-of-polyphenolic-compounds-in-the-alpha-amylase-and-alpha-glucosidase-inhibitory-potentials-of-extracts-from-the-leaves-of-acalypha-godseffiana-from-eastern-nigeria-an-in-vitro-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61511.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">262</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14761</span> A Comparative Study on the Hypoglycemic Effects of Hydroalcoholic Extracts from Silybum marianum, Camellia sinensis (Green Tea), and Urtica dioica Plants in Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sogand%20Moshfeghi">Sogand Moshfeghi</a>, <a href="https://publications.waset.org/abstracts/search?q=Alireza%20Biglari"> Alireza Biglari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes is an endocrine disorder that is commonly treated with insulin. However, long-term usage of insulin and hypoglycemic chemical drugs can result in various side effects. Therefore, it is crucial to explore effective compounds with minimal side effects for diabetes treatment. This study aimed to compare the hypoglycemic effects of hydroalcoholic extracts derived from Silybum marianum, Camellia sinensis (green tea), and Urtica dioica plants. Male Wistar rats were allocated to 5 groups. Group 1 received normal Salin. Other groups were diabetic (induced by Streptozotocin 65 mg/kg Ip), group 2 received normal Salin (Ip, qod. 21 days). Group 3 received Silybum Marianum L, hydroalcoholic extract (100 mg/kg, ip.qod, 21 days). Group 4 received Camellia sinesis L, hydroalcoholic extract (100mg/kg,ip,qod,21 days), and group 5 received Urtica dioica L. hydroalcoholic extract (100mg/kg, ip,qod,21 days). Blood samples were collected at 14 and 21 days after the initial injection to evaluate the blood glucose levels. On the fourteenth day, the blood glucose levels for the diabetic groups were as follows: Group 2: 424.7±34.5, Group 3: 390.7±10.5, Group 4: 350.4±16.9, and Group 5: 340±20.5. On the 21st day, the respective blood glucose levels were: Group 2: 432±5.0, Group 3: 410.16±5.0, Group 4: 264.3±17.5, and Group 5: 270.7±24.5. Statistical analysis using the Tukey Anova test indicated that on the fourteenth day, both the green tea and Urtica groups exhibited significant hypoglycemic effects. Furthermore, on the 21st day, Urtica dioica extract demonstrated comparable effects to Camellia Sinensis extract, while Silybum Marianum extract did not significantly lower blood glucose levels compared to the diabetic group. In conclusion, the hydroalcoholic extracts from Camellia sinensis and Urtica dioica plants exhibited promising hypoglycemic effects in diabetic rats. These findings provide valuable insights into the potential use of natural plant extracts as alternative or complementary treatments for diabetes, warranting further investigation to harness their therapeutic benefit effectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Camellia%20sinesis" title="Camellia sinesis">Camellia sinesis</a>, <a href="https://publications.waset.org/abstracts/search?q=glucose" title=" glucose"> glucose</a>, <a href="https://publications.waset.org/abstracts/search?q=Silybum%20marianum" title=" Silybum marianum"> Silybum marianum</a>, <a href="https://publications.waset.org/abstracts/search?q=Urtica%20dioica" title=" Urtica dioica"> Urtica dioica</a> </p> <a href="https://publications.waset.org/abstracts/173030/a-comparative-study-on-the-hypoglycemic-effects-of-hydroalcoholic-extracts-from-silybum-marianum-camellia-sinensis-green-tea-and-urtica-dioica-plants-in-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/173030.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">72</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14760</span> The Effect of Dendrobium nobile Lindl. Alkaloids on the Blood Glucose and Amyloid Precursor Protein Metabolic Pathways in Db/Db Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Juan%20Huang">Juan Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Nanqu%20Huang"> Nanqu Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jingshan%20Shi"> Jingshan Shi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu%20Qiu"> Yu Qiu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: There are pathophysiological connections between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), and research on drugs with hypoglycemic and beta-amyloid (Aβ)-clearing effects have great therapeutic potential for AD. Dendrobium nobile Lindl. Alkaloids (DNLA) as one of the active compounds of Dendrobium nobile Lindl. In this study, we attempted to verify the hypoglycemic effect and investigate the effects of DNLA on the amyloid precursor protein (APP) metabolic pathway of the hippocampus in db/db mice. Methods: 4-weeks-old male C57BL/KsJ mice were the control group. And the same age and sexuality db/db mice were: model, DNLA-L (20 mg/kg), DNLA-M (40 mg/kg), and DNLA-H (80 mg/kg). After, mice were treated with different concentrations of DNLA for 17 weeks. The fasting blood glucose (FBG) was detected by glucose oxidase assay every week from the 4th to last week. The protein expression of β-amyloid 1-42 (Aβ1-42), β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), and APP were examined by Western blotting. Results: The concentration of FBG and the protein expression of Aβ1-42, BACE1, and APP were increased in the hippocampus of the model group. Moreover, DNLA not only significantly decreased the concentration of FBG but also reduced the protein expressions of Aβ1-42, BACE1 and APP in the hippocampus of db/db mice in a dose-dependent manner. Conclusions: DNLA can decrease the protein expressions of Aβ1-42 in the hippocampus of db/db mice, and the mechanism may be involved in the APP metabolic pathway. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alzheimer%27s%20disease" title="Alzheimer's disease">Alzheimer's disease</a>, <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes%20mellitus" title=" type 2 diabetes mellitus"> type 2 diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B2-site%20amyloid%20precursor%20protein-cleaving%20enzyme%201" title=" β-site amyloid precursor protein-cleaving enzyme 1"> β-site amyloid precursor protein-cleaving enzyme 1</a>, <a href="https://publications.waset.org/abstracts/search?q=traditional%20Chinese%20medicines" title=" traditional Chinese medicines"> traditional Chinese medicines</a>, <a href="https://publications.waset.org/abstracts/search?q=beta-amyloid" title=" beta-amyloid"> beta-amyloid</a> </p> <a href="https://publications.waset.org/abstracts/152548/the-effect-of-dendrobium-nobile-lindl-alkaloids-on-the-blood-glucose-and-amyloid-precursor-protein-metabolic-pathways-in-dbdb-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152548.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">255</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14759</span> The Antidiabetic Properties of Indonesian Swietenia mahagoni in Alloxan-Induced Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=T.%20Wresdiyati">T. Wresdiyati</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Sa%E2%80%99diah"> S. Sa’diah</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Winarto"> A. Winarto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus (DM) is a metabolic disease that can be indicated by the high level of blood glucose. The objective of this study was to observe the antidiabetic properties of ethanolic extract of Indonesian <em>Swietenia mahagoni </em>Jacq. seed on the profile of pancreatic superoxide dismutase and β-cells in the alloxan- experimental diabetic rats. The <em>Swietenia mahagoni </em>seed was obtained from Leuwiliang-Bogor, Indonesia. Extraction of <em>Swietenia mahagoni </em>was done by using ethanol with maceration methods. A total of 25 male <em>Sprague dawley </em>rats were divided into five groups; (a) negative control group, (b) positive control group (DM), (c) DM group that was treated with <em>Swietenia mahagoni</em> seed extract, (d) DM group that was treated with acarbose, and (e) non-DM group that was treated with <em>Swietenia mahagoni </em>seed extract. The DM groups were induced by alloxan (110 mg/kgBW). The extract was orally administrated to diabetic rats 500 mg/kg/BW/day for 28 days. The extract showed hypoglycemic effect, increased body weight, increased the content of superoxide dismutase in the pancreatic tissue, and delayed the rate of β-cells damage of experimental diabetic rats. These results suggested that the ethanolic extract of Indonesian <em>Swietenia mahagoni </em>Jacq. seed could be proposed as a potential anti-diabetic agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beta%20cells" title="beta cells">beta cells</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic" title=" hypoglycemic"> hypoglycemic</a>, <a href="https://publications.waset.org/abstracts/search?q=rat" title=" rat"> rat</a>, <a href="https://publications.waset.org/abstracts/search?q=Swietenia%20mahagoni" title=" Swietenia mahagoni"> Swietenia mahagoni</a> </p> <a href="https://publications.waset.org/abstracts/50793/the-antidiabetic-properties-of-indonesian-swietenia-mahagoni-in-alloxan-induced-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50793.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14758</span> Hypoglycemic and Hypolipidemic Effects of Aqueous Flower Extract from Nyctanthes arbor-tristis L.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Brahmanage%20S.%20Rangika">Brahmanage S. Rangika</a>, <a href="https://publications.waset.org/abstracts/search?q=Dinithi%20C.%20Peiris"> Dinithi C. Peiris</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Boiled Aqueous Flower Extract (AFE) of Nyctanthes arbor-tristis L. (Family: Oleaceae) is used in traditional Sri Lankan medicinal system to treat diabetes. However, this is not scientifically proven and the mechanisms by which the flowers reduce diabetes have not been investigated. The present study was carried out to examine the hypoglycemic potential and toxicity effects of aqueous flower extract of N. arbor-tristis. AFE was prepared and mice were treated orally either with 250, 500, and 750 mg/kg of AFE or distilled water (Control). Fasting and random blood glucose levels were determined. In addition, the toxicity of AFE was determined using chronic oral administration. In normoglycemic mice, mid dose (500mg/kg) of AFE significantly (p < 0.01) reduced fasting blood glucose levels by 49% at 4h post treatment. Further, 500mg/kg of AFE significantly (p < 0.01) lowered random blood glucose level of non-fasted normoglycemic mice. AFE significantly lowered total cholesterol and triglyceride levels while increasing the HDL levels in the serum. Further, AFE significantly inhibited the glucose absorption from the lumen of the intestine and it increases the diaphragm uptake of glucose. Alpha-amylase inhibitory activity was also evident. However, AFE did not induce any overt signs of toxicity or hepatotoxicity. There were no adverse effects on food and water intake and body weight of mice during the experimental period. It can be concluded that AFE of N. arbor-tristis posses safe oral anti diabetic potentials mediated via multiple mechanisms. Results of the present study scientifically proved the claims made about the uses of N. arbor-tristis in the treatment of diabetes mellitus in traditional Sri Lankan medicinal system. Further, flowers can also be used for as a remedy to improve blood lipid profile. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title="aqueous extract">aqueous extract</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20hypolipidemic" title=" hypoglycemic hypolipidemic"> hypoglycemic hypolipidemic</a>, <a href="https://publications.waset.org/abstracts/search?q=Nyctanthes%20arbor-tristis%20flowers" title=" Nyctanthes arbor-tristis flowers"> Nyctanthes arbor-tristis flowers</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatotoxicity" title=" hepatotoxicity"> hepatotoxicity</a> </p> <a href="https://publications.waset.org/abstracts/15067/hypoglycemic-and-hypolipidemic-effects-of-aqueous-flower-extract-from-nyctanthes-arbor-tristis-l" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15067.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">370</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14757</span> Effectively Improving Cognition, Behavior, and Attitude of Diabetes Inpatients through Nutritional Education</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Han%20Chih%20Feng">Han Chih Feng</a>, <a href="https://publications.waset.org/abstracts/search?q=Yi-Cheng%20Hou"> Yi-Cheng Hou</a>, <a href="https://publications.waset.org/abstracts/search?q=Jing-Huei%20Wu"> Jing-Huei Wu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes is a chronic disease. Nutrition knowledge and skills enable individuals with type 2 diabetes to optimize metabolic self-management and quality of life. This research studies the effect of nutritional education on diabetes inpatients in terms of their cognition, behavior, and attitude. The participants are inpatients diagnosed with diabetes at Taipei Tzu Chi Hospital. A total of 103 participants, 58 male, and 45 females, enrolled in the research between January 2018 and July 2018. The research evaluates cognition, behavior, and attitude level before and after nutritional education conducted by dietitians. The result shows significant improvement in actual consumption (2.5 ± 1.4 vs 3.8 ± 0.7; p<.001), diet control motivation (2.7 ± 0.8 vs 3.4 ± 0.6; p<.001), correct nutrition concept (1.2± 0.4 vs 2.4 ± 0.5; p<.001), learning willingness (2.7± 0.9 vs 3.4 ± 0.6; p<.001), cognitive behaviors (1.4 ± 0.5 vs 2.9 ± 0.7; p<.001). AC sugar (278.5 ± 321.5 vs 152.2 ± 49.1; p<.001) and HbA1C (10.3 ± 2.6 vs 8.6 ± 1.9; p<.001) are significant improvement after nutritional education. After nutritional education, participants oral hypoglycemic agents increased from 16 (9.2%) to 33 (19.0%), insulin decreased from 75 (43.1%) to 68 (39.1%), and hypoglycemic drugs combined with insulin decreased from 83 (47.7%) to 73 (42.0%).Further analysis shows that female inpatients have significant improvement in diet control motivation (3.91 ± 0.85 vs 4.44 ± 0.59; p<0.000), correct nutrition concept (3.24± 0.48 vs 4.47± 0.51; p<0.000), learning willingness (3.89 ± 0.86 vs 4.44 ± 0.59; p<0.000) and cognitive behaviors (2.42 ± 0.58 vs 4.02 ± 0.69; p<0.000); male inpatients have significant improvement in actual food intake (4.41± 0.92 vs 3.97 ± 0.42; p<0.000), diet control motivation (3.62 ± 0.86 vs 4.29 ± 0.62; p<0.000), correct nutrition concept (3.26 ± 0.44 vs 4.36 ± 0.49; p<0.000), learning willingness (3.72± 0.93 vs 4.33± 0.63; p<0.000) and cognitive behaviors (2.45± 0.54 vs 4.03± 0.77; p<0.000). In conclusion, nutritional education proves effective, regardless of gender, in improving an inpatient’s cognition, behavior, and attitude toward diabetes self-management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrition%20education" title=" nutrition education"> nutrition education</a>, <a href="https://publications.waset.org/abstracts/search?q=actual%20consumption" title=" actual consumption"> actual consumption</a>, <a href="https://publications.waset.org/abstracts/search?q=diet%20control%20motivation" title=" diet control motivation"> diet control motivation</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrition%20concept" title=" nutrition concept"> nutrition concept</a>, <a href="https://publications.waset.org/abstracts/search?q=learning%20willingness" title=" learning willingness"> learning willingness</a>, <a href="https://publications.waset.org/abstracts/search?q=cognitive%20behaviors" title=" cognitive behaviors"> cognitive behaviors</a> </p> <a href="https://publications.waset.org/abstracts/149917/effectively-improving-cognition-behavior-and-attitude-of-diabetes-inpatients-through-nutritional-education" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149917.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14756</span> Potency of Strophanthus hispidus Stem Bark in the Management of Streptozotocin-Induced Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Osibemhe">M. Osibemhe</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20O.%20Onoagbe"> I. O. Onoagbe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus is a common disease that has no known cure. The available orthodox drugs used for its management have one or more disadvantages. This study investigated the potency of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in the management of diabetes mellitus. Glucose concentration and lipid profile parameters of normal and streptozotocin-induced diabetic rats were monitored for 12weeks. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Male rats (wistar strain) numbering 30 were randomly selected into six groups of five rats each. Groups 1 and 6 served as normal and diabetic control respectively and received distilled water for 12weeks. Groups 2 and 3 were normal rats treated orally with the aid of a gavage, 250 mg/kg of aqueous and ethanol extracts respectively for 12weeks. Groups 4 and 5 were diabetic rats and were treated with the respective dose of aqueous and ethanol extracts for the same period. A significant (P˂0.05) progressive decrease in blood glucose concentrations of both normal and diabetic rats treated with the extracts were observed from the 2nd to 12th weeks when compared with the respective controls. No significant (P˃0.05) effects were observed in the basal values of both normal and diabetic rats. Administration of both extracts of SH to diabetic rats significantly (P˂0.05) lowered the concentrations of Total cholesterol, TG, and LDL, whereas it increases the concentration of HDL when compared with diabetic control. The concentrations of total cholesterol and LDL in normal rats treated with SH were also reduced when compared with normal control whereas SH had no significant (P˃0.05) effect on HDL. However, TG level of normal control was significantly (P˂0.05) lower than normal rats treated with both extracts. A progressive increase in weight of normal and diabetic rats treated with the extracts was observed on the 2nd – 12th weeks of administration, whereas diabetic control showed a progressive decrease in weight. The findings from this study indicated that SH has hypoglycemic and anti-lipidemic properties as well as anti-diabetic potentials. It also showed that ethanol extract had greater glucose lowering effect. Hence, SH may be considered as a potent anti-diabetic plant and could be used as alternative drug for the management of diabetes mellitus. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=concentration" title="concentration">concentration</a>, <a href="https://publications.waset.org/abstracts/search?q=ethanol%20extract" title=" ethanol extract"> ethanol extract</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic" title=" hypoglycemic"> hypoglycemic</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20cholesterol" title=" total cholesterol"> total cholesterol</a> </p> <a href="https://publications.waset.org/abstracts/52175/potency-of-strophanthus-hispidus-stem-bark-in-the-management-of-streptozotocin-induced-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52175.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">216</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14755</span> Effect of Diet and Life Style Modification to Control the Plasma Glucose Level in the 60 Patients of Gestational Diabetes Mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vivek%20Saxena">Vivek Saxena</a>, <a href="https://publications.waset.org/abstracts/search?q=Shreshtha%20Saxena"> Shreshtha Saxena</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance first recognized during pregnancy. Uncontrolled or untreated GDM is associated with various adverse outcomes to the maternal and fetal health. Overt diabetes mellitus may also develop in such patients. It is universally accepted fact that first and foremost management to treat GDM is dietary control and lifestyle modification even before starting any oral hypoglycemic agent (OHA) or insulin. So, proper dietary management and little changes in the patient’s lifestyle are very effective for reducing her plasma glucose level. Objectives: Proper counselling of the patients and flexibility in their lifestyle and diet can effectively control the plasma glucose level in GDM patients. Methods: Total 60 GDM patients of age > 18 years were taken. We had three counselling sessions with the patient and other members of the family like husband, parents, and in-laws at different intervals, discussed their lifestyle and diet pattern, helped them to eliminate the factors those had an adverse effect on plasma glucose level and promoted them to acquire a healthy lifestyle. We have counselled the patient and her family member separately and then together also. They have explained how increased plasma glucose level can be effectively controlled with the little modification in their diet and routine activities. They were also taught to remain stress-free during their rest of antenatal period. We have excluded the patients from our study who were diabetic before pregnancy and patients with other comorbid illnesses like hypothyroidism and valvular heart disease. Results and conclusions: Results were very rewarding as patients could acquire a lifestyle of their choice. They were happy because extra pill burden was not there. All the 60 patients were normoglycemic in remaining antenatal period, 48 patients were delivered normally and 12 patients underwent cesarean section due to various reasons.Regular counselling of the patients regarding their disease and little alterations in diet and lifestyle controlled the plasma glucose level much effectively. The things were more easier and effective when we included other family members during our counselling session because they play a major role in patient’s day to day activity and influence her life. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dietary%20management" title="dietary management">dietary management</a>, <a href="https://publications.waset.org/abstracts/search?q=gestational%20diabetes%20mellitus" title=" gestational diabetes mellitus"> gestational diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=impaired%20glucose%20tolerance" title=" impaired glucose tolerance"> impaired glucose tolerance</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20hypoglycemic%20agent" title=" oral hypoglycemic agent"> oral hypoglycemic agent</a>, <a href="https://publications.waset.org/abstracts/search?q=pregnancy" title=" pregnancy"> pregnancy</a> </p> <a href="https://publications.waset.org/abstracts/93279/effect-of-diet-and-life-style-modification-to-control-the-plasma-glucose-level-in-the-60-patients-of-gestational-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93279.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14754</span> Study and Melanocyte Adrenocorticotropic Effects on Sugar Metabolism and Immune Response in Rabbits Oryctolagus cuniculus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Bouaouiche">A. Bouaouiche</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Boulakoud"> M. S. Boulakoud </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The functioning of the pineal gland, the transducer body of environmental information to the neuroendocrine system is subject to a circadian rhythm. Melatonin is the main neuro-hormone expressing this operation. It is synthesized in the pinealocytes after conversion serotonin via N-acetyl-transferase enzyme, itself subject to a photoperiodic modulation (activation dark inhibition by light). Some authors have suggested that melatonin is involved in diabetic disease and found that it could have a diabetogenic effect. To this study the effect of this hormone on glucose metabolism has long been subject to controversy. Agreeing in effect and hyperinsulinemic hypoglycemic effect. In order to illustrate the level of interaction of melatonin with neuro-immune- corticotropin axis and its impact on carbohydrate metabolism, we studied the impact homeostatic (glucose) through the solicitation of two control systems (gland pineal and corticotropin axis). We then found that melatonin could have an indirect influence on insulin control (glucose metabolism) to the levels of the growth hormone axis (somatostatin) and adrenocorticotropic (corticotropin). In addition, we have suggested that melatonin might limit the hyperglycemic action of corticosteroids by direct action at peripheral level. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pin%C3%A9al%20gland" title="pinéal gland">pinéal gland</a>, <a href="https://publications.waset.org/abstracts/search?q=melatonin" title=" melatonin"> melatonin</a>, <a href="https://publications.waset.org/abstracts/search?q=neuro-immuno-corticotrop" title=" neuro-immuno-corticotrop"> neuro-immuno-corticotrop</a>, <a href="https://publications.waset.org/abstracts/search?q=metabolism" title=" metabolism "> metabolism </a> </p> <a href="https://publications.waset.org/abstracts/23778/study-and-melanocyte-adrenocorticotropic-effects-on-sugar-metabolism-and-immune-response-in-rabbits-oryctolagus-cuniculus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23778.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">476</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14753</span> Effect of Neem Leaves Extract (Azadirachta Indica) on Blood Glucose Level and Lipid Profile in Normal and Alloxan-Diabetic Rabbits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khalil%20Abdullah%20Ahmed%20Khalil">Khalil Abdullah Ahmed Khalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsadig%20Mohamed%20Ahmed"> Elsadig Mohamed Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Extracts of various plants material capable of decreasing blood sugar have been tested in experimental animal models, and their effects confirmed. Neem or Margose (AzadirachtaIndica) is an indigenous plant believed to have antiviral, antifungal, antidiabetic, and many other properties. In this paper deals with a comparative study of effect of aqueous Neem leaves extract alone or in combination with glibenclamide on alloxan diabetic rabbits. Administration of crude aqueous Neem extract (CANE) alone (1.5 ml/kg/day) as well as the combination of CANE (1.5 ml/kg/day) with glibenclamide (0.25 mg/kg/day) significantly decreased (P<0.05) the concentrations of serum lipids, blood glucose and lipoprotein VLDL and LDL but significantly increased (P<0.05) the concentration of HDL. The change was observed significantly greater when the treatment was given in combination of CANE and glibenclamid than with CANE alone. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aqueos%20neem%20leaves%20extract" title="aqueos neem leaves extract">aqueos neem leaves extract</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic" title=" hypoglycemic"> hypoglycemic</a>, <a href="https://publications.waset.org/abstracts/search?q=hypolipidemic" title=" hypolipidemic"> hypolipidemic</a>, <a href="https://publications.waset.org/abstracts/search?q=cholesterol" title=" cholesterol"> cholesterol</a> </p> <a href="https://publications.waset.org/abstracts/143561/effect-of-neem-leaves-extract-azadirachta-indica-on-blood-glucose-level-and-lipid-profile-in-normal-and-alloxan-diabetic-rabbits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143561.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14752</span> A New Technology for Metformin Hydrochloride Mucoadhesive Microparticles Preparation Utilizing BÜCHI Nano-Spray Dryer B-90</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tamer%20M.%20Shehata">Tamer M. Shehata</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: Currently, mucoadhesive microparticles acquired a high interest in both research and pharmaceutical technology fields. Recently, BÜCHI lunched its latest fourth generation nano spray dryer B-90 used for nanoparticle production. B-90 offers an elegant technology combined particle engineering and drying in one step. In our laboratory, we successfully developed a new formulation for metformin hydrochloride, mucoadhesive microparticles utilizing B-90 technology for treatment of type 2-diabetis. Method: Gelatin or sodium alginate, natural occurring polymers with mucoadhesive properties, solely or in combination was used in our formulation trials. Preformulation studies (atomization head mesh size, flow rate, head temperature, polymer solution viscosity and surface tension) and postformulation characters (particle size, flowability, surface scan and dissolution profile) were evaluated. Finally, hypoglycemic effect of the selected formula was evaluated in streptozotocin-induced diabetic rats. Spray head with 7 µm hole, flow rate of 3.5 mL/min and head temperature 120 ºC were selected. Polymer viscosity was less than 11.5 cP with surface tension less than 70.1 dyne/cm. Result: Discrete, non aggregated particles and free flowing powders with particle size was less than 2000 nm were obtained. Gelatin and sodium alginate combination in ratio 1:3 were successfully sustained the in vitro release profile of the drug. Hypoglycemic evaluation of the previous formula, showed a significant reduction of blood glucose level over 24 h. Conclusion: B-90 technology can open a new era of , mucoadhesive microparticles preparation offering convenient dosage form that can enhance compliance of type 2 diabetic patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mucoadhesive" title="mucoadhesive">mucoadhesive</a>, <a href="https://publications.waset.org/abstracts/search?q=microparticles" title=" microparticles"> microparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=technology" title=" technology"> technology</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetis" title=" diabetis"> diabetis</a> </p> <a href="https://publications.waset.org/abstracts/40380/a-new-technology-for-metformin-hydrochloride-mucoadhesive-microparticles-preparation-utilizing-buchi-nano-spray-dryer-b-90" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40380.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14751</span> Antioxidant, Hypoglycemic and Hypotensive Effects Affected by Various Molecular Weights of Cold Water Extract from Pleurotus Citrinopileatus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pao-Huei%20Chen">Pao-Huei Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Shu-Mei%20Lin"> Shu-Mei Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Yih-Ming%20Weng"> Yih-Ming Weng</a>, <a href="https://publications.waset.org/abstracts/search?q=Zer-Ran%20Yu"> Zer-Ran Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Be-Jen%20Wang"> Be-Jen Wang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Pancreatic α-amylase and intestinal α-glucosidase are the critical enzymes for the breakdown of complex carbohydrates into di- or mono-saccharide, which play an important role in modulating postprandial blood sugars. Angiotensin converting enzyme (ACE) converts inactive angiotensin-I into active angiotensin-II, which subsequently increase blood pressure through triggering vasoconstriction and aldosterone secretion. Thus, inhibition of carbohydrate-digestion enzymes and ACE will help the management of blood glucose and blood pressure, respectively. Studies showed Pleurotus citrinopileatus (PC), an edible mushroom and commonly cultured in oriental countries, exerted anticancer, immune improving, antioxidative, hypoglycemic and hypolipidemic effects. Previous studies also showed various molecular weights (MW) fractioned from extracts may affect biological activities due to varying contents of bioactive components. Thus, the objective of this study is to investigate the in vitro antioxidant, hypoglycemic and hypotenstive effects and distribution of active compounds of various MWs of cold water extract from P. citrinopileatus (CWEPC). CWEPC was fractioned into four various MW fractions, PC-I (＜1 kDa), PC-II (1-3.5 kDa), PC-III (3.5-10 kDa), and PC-IV (＞10 kDa), using an ultrafiltration system. The physiological activities, including antioxidant activities, the inhibition capabilities of pancreatic α-amylase, intestinal α-glucosidase, and hypertension-linked ACE, and the active components, including polysaccharides, protein, and phenolic contents, of CWEPC and four fractions were determined. The results showed that fractions with lower MW exerted a higher antioxidant activity (p<0.05), which was positively correlated to the levels of total phenols. In contrast, the inhibition effects on the activities of α-amylase, α-glucosidase, and ACE of PC-IV fraction were significantly higher than CWEPC and the other three low MW fractions (< 10 kDa), which was more related to protein contents. The inhibition capability of CWEPC and PC-IV on α-amylase activity was 1/13.4 to 1/2.7 relative to that of acarbose (positive control), respectively. However, the inhibitory ability of PC-IV on α-glucosidase (IC50 = 0.5 mg/mL) was significantly higher than acarbose (IC50 = 1.7 mg/mL). Kinetic data revealed that PC-IV fraction followed a non-competitive inhibition on α-glucosidase activity. In conclusion, the distribution of various bioactive components contribute to the functions of different MW fractions on oxidative stress prevention, and blood pressure and glucose modulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-Amylase" title="α-Amylase">α-Amylase</a>, <a href="https://publications.waset.org/abstracts/search?q=angiotensin%20converting%20enzyme" title=" angiotensin converting enzyme"> angiotensin converting enzyme</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-Glucosidase" title=" α-Glucosidase"> α-Glucosidase</a>, <a href="https://publications.waset.org/abstracts/search?q=Pleurotus%20citrinopileatus" title=" Pleurotus citrinopileatus"> Pleurotus citrinopileatus</a> </p> <a href="https://publications.waset.org/abstracts/25984/antioxidant-hypoglycemic-and-hypotensive-effects-affected-by-various-molecular-weights-of-cold-water-extract-from-pleurotus-citrinopileatus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25984.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">460</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14750</span> Effect of Cistanche tinctoria Methanolic Extract on the Maternal-Fetal Outcome and Oxidative Stress Biomarkers of Streptozotocin-Induced Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amina%20Bouzitouna">Amina Bouzitouna</a>, <a href="https://publications.waset.org/abstracts/search?q=Kheireddine%20Ouali"> Kheireddine Ouali</a>, <a href="https://publications.waset.org/abstracts/search?q=Sandra%20Amri"> Sandra Amri</a>, <a href="https://publications.waset.org/abstracts/search?q=Houria%20Rahmoun"> Houria Rahmoun</a>, <a href="https://publications.waset.org/abstracts/search?q=Mourad%20Bensouilah"> Mourad Bensouilah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim of this study: To evaluate the effect of Cisthanche tinctoria treatment on maternal-fetal outcome and antioxidant systems of streptozotocin-induced diabetic rats. Materials and methods: Virgin female Wistar rats were injected with 50 mg/kg streptozotocin before mating. Oral administration of an methanolic extract of Cistanche tinctoria was given to non-diabetic and diabetic pregnant rats at doses of 200 mg/kg from 0 to 19th day of pregnancy. At day 20 of pregnancy the rats were killed and a maternal blood sample was collected for the determination Vitamin C (Vit C) and malonaldehyde (MDA). The gravid uterus was weighed with its contents and fetuses were analyzed. Results and conclusion: The data showed that the diabetic dams presented an increased glycemic level, resorption, placental weight, placental index, and fetal anomalies, and reduced VIT C and MDA determinations, live fetuses, maternal weight gain, gravid uterine weight, and fetal weight. It was also verified that Cisthanche tictoria treatment had no hypoglycemic effect, did not improve maternal outcomes in diabetic rats, but it contributed to maintain GSH concentration similarly to non-diabetic groups, suggesting relation with the decreased incidence of visceral anomalies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cistanche%20tinctoria" title="cistanche tinctoria">cistanche tinctoria</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=pregnancy" title=" pregnancy"> pregnancy</a>, <a href="https://publications.waset.org/abstracts/search?q=reproductive%20outcome" title=" reproductive outcome"> reproductive outcome</a>, <a href="https://publications.waset.org/abstracts/search?q=anomaly" title=" anomaly"> anomaly</a>, <a href="https://publications.waset.org/abstracts/search?q=orobanchac%C3%A9es" title=" orobanchacées"> orobanchacées</a> </p> <a href="https://publications.waset.org/abstracts/13058/effect-of-cistanche-tinctoria-methanolic-extract-on-the-maternal-fetal-outcome-and-oxidative-stress-biomarkers-of-streptozotocin-induced-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13058.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">457</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14749</span> Paradigm Shift in Classical Drug Research: Challenges to Mordern Pharmaceutical Sciences</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Riddhi%20Shukla">Riddhi Shukla</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajeshri%20Patel"> Rajeshri Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Prakruti%20Buch"> Prakruti Buch</a>, <a href="https://publications.waset.org/abstracts/search?q=Tejas%20Sharma"> Tejas Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Mihir%20Raval"> Mihir Raval</a>, <a href="https://publications.waset.org/abstracts/search?q=Navin%20Sheth"> Navin Sheth</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Many classical drugs are claimed to have blood sugar lowering properties that make them valuable for people with or at high risk of type 2 diabetes. Vijaysar (Pterocarpus marsupium) and Gaumutra (Indian cow urine) both have been shown antidiabetic property since primordial time and both shows synergistic effect in combination for hypoglycaemic activity. The study was undertaken to investigate the hypoglycaemic and anti-diabetic effects of the combination of Vijaysar and Gaumutra which is a classical preparation mentioned in Ayurveda named as Pramehari ark. Rats with Type 2 diabetes which is induced by streptozotocin (STZ, 35mg/kg) given a high-fat diet for one month and compared with normal rats. Diabetic rats showed raised level of body weight, triglyceride (TG), total cholesterol, HDL, LDL, and D-glucose concentration and other serum, cardiac and hypertrophic parameters in comparison of normal rats. After treatment of different doses of drug the level of parameters like TG, total cholesterol, HDL, LDL, and D-glucose concentration found to be decreased in standard as well as in treatment groups. In addition treatment groups also found to be decreased in the level of serum markers, cardiac markers, and hypertrophic parameters. The ﬁndings demonstrated that Pramehari ark prevented the pathological progression of type 2 diabetes in rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cow%20urine" title="cow urine">cow urine</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20effect" title=" hypoglycemic effect"> hypoglycemic effect</a>, <a href="https://publications.waset.org/abstracts/search?q=synergic%20effect" title=" synergic effect"> synergic effect</a>, <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes" title=" type 2 diabetes"> type 2 diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=vijaysar" title=" vijaysar"> vijaysar</a> </p> <a href="https://publications.waset.org/abstracts/70388/paradigm-shift-in-classical-drug-research-challenges-to-mordern-pharmaceutical-sciences" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/70388.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">279</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14748</span> Effect of Different Parameters in the Preparation of Antidiabetic Microparticules by Coacervation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nawel%20Ouennoughi">Nawel Ouennoughi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamel%20Daoud"> Kamel Daoud</a> </p> <p class="card-text"><strong>Abstract:</strong></p> During recent years, new pharmaceutical dosage forms were developed in the research laboratories and which consists of encapsulating one or more active molecules in a polymeric envelope. Several techniques of encapsulation allow obtaining the microparticles or the nanoparticles containing one or several polymers. In the industry, microencapsulation is implemented to fill the following objectives: to ensure protection, the compatibility and the stabilization of an active matter in a formulation, to carry out an adapted working, to improve the presentation of a product, to mask a taste or an odor, to modify and control the profile of release of an active matter to obtain, for example, prolonged or started effect. To this end, we focus ourselves on the encapsulation of the antidiabetic. It is an oral hypoglycemic agent belonging to the second generation of sulfonylurea’s commonly employed in the treatment of type II non-insulin-dependent diabetes in order to improve profile them dissolution. Our choice was made on the technique of encapsulation by complex coacervation with two types of polymers (gelatin and the gum Arabic) which is a physicochemical process. Several parameters were studied at the time of the formulation of the microparticles and the nanoparticles: temperature, pH, ratio of polymers etc. The microparticles and the nanoparticles obtained were characterized by microscopy, laser granulometry, FTIR and UV-visible spectrophotometry. The profile of dissolution obtained for the microparticles showed an improvement of the kinetics of dissolution compared to that obtained for the active ingredient. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=coacervation" title="coacervation">coacervation</a>, <a href="https://publications.waset.org/abstracts/search?q=gum%20Arabic" title=" gum Arabic"> gum Arabic</a>, <a href="https://publications.waset.org/abstracts/search?q=microencapsulation" title=" microencapsulation"> microencapsulation</a>, <a href="https://publications.waset.org/abstracts/search?q=gelatin" title=" gelatin"> gelatin</a> </p> <a href="https://publications.waset.org/abstracts/39396/effect-of-different-parameters-in-the-preparation-of-antidiabetic-microparticules-by-coacervation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39396.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14747</span> Oral Lichen Planus a Manifestation of Grinspan's Syndrome or a Lichenoid Reaction to Medication</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sahar%20Iqrar">Sahar Iqrar</a>, <a href="https://publications.waset.org/abstracts/search?q=Malik%20Adeel%20Anwar"> Malik Adeel Anwar</a>, <a href="https://publications.waset.org/abstracts/search?q=Zain%20Akram"> Zain Akram</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Noor"> Maria Noor</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Oral lichen planus is a chronic inflammatory condition of unknown etiology. Oral lichen planus may be related with several other diseases. Grinspan's Syndrome is characterized by a triad of oral lichen planus, hypertension, and diabetes mellitus. Other associations reported in the literature are with chronic liver disease and, with dyslipidemia. The nature of these associations is still not fully understood. Material and methods: Study was conducted in Department of Oral Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan. A total of n=89 clinically diagnosed patients of oral lichen planus of both gender and all age groups were recruited and detailed history were recorded in the designed performs. Results: A total of n=89 patients were taken with male to female ratio of 3:8 in which 24 were male and 65 females. Mean age was 48.8 ± 13.8 years. Age range of 10-74 years was seen. Among these patients suffering from oral lichen planus, 41.6% (n=37) had a positive history for hypertension with 59.5% (n=22) of these patients were taking different medication for their condition. Whereas Diabetes Mellitus was found in 24.7% (n=22) patients with 72.7% (n=16) of these patients using the hypoglycemic drug (oral or injectable) to control their blood glucose levels. Out of these n=89 lichen planus patients 21.3% had both hypertension and diabetes mellitus (fulfilling the criteria for Grinspan's Syndrome). Out of this Grinspan's Syndrome pool 94.7% (n=19) were taking drug atleast for one of the two conditions. Conclusion: As noticed form the medical history of the patients, most of them were using hypoglycemic drugs for diabetes mellitus and beta blockers, diuretics and calcium channel blockers for hypertension. These drugs are known for lichenoid reaction. Therefore, it should be ruled out at histopathological/ immunological and molecular level whether these patients are suffering from lichen planus or lichenoid drug reaction to truly declare them as patients with Grinspan’s Syndrome. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus" title="diabetes mellitus">diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=grinspan%27s%20syndrome" title=" grinspan's syndrome"> grinspan's syndrome</a>, <a href="https://publications.waset.org/abstracts/search?q=lichenoid%20drug%20reaction" title=" lichenoid drug reaction"> lichenoid drug reaction</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20lichen%20planus" title=" oral lichen planus"> oral lichen planus</a> </p> <a href="https://publications.waset.org/abstracts/48480/oral-lichen-planus-a-manifestation-of-grinspans-syndrome-or-a-lichenoid-reaction-to-medication" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48480.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">241</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14746</span> Antidiabetic and Antihyperlipaemic Effects of Aqueous Neem (Azadirachta Indica) Extract on Alloxan Diabetic Rabbits</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khalil%20Abdullah%20Ahmed%20Khalil">Khalil Abdullah Ahmed Khalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsadig%20Mohamed%20Ahmed"> Elsadig Mohamed Ahmed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Extracts of various plants material capable of decreasing blood sugar have been tested in experimental animal models and their effects confirmed. Neem or Margose (Azadirachta Indica) is an indigenous plant believed to have antiviral, antifungal, antidiabetic and many other properties. This paper deals with a comparative study of the effect of aqueous Neem leaves extract alone or in combination with glibenclamide on alloxan diabetic rabbits. Administration of crude aqueous Neem extract (CANE) alone (1.5 ml/kg/day), as well as the combination of CANE (1.5 ml/kg/day) with glibenclamide (0.25 mg/kg/day) significantly, decreased (P<0.05) the concentrations of serum lipids, blood glucose and lipoprotein VLDL(very low-density lipoproteins) and LDL(low-density lipoproteins) but significantly increased (P<0.05) the concentration of HDL(high-density lipoprotein). The change was observed significantly greater when the treatment was given in combination of CANE and glibenclamid than with CANE alone. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neem" title="neem">neem</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycemic" title=" hypoglycemic"> hypoglycemic</a>, <a href="https://publications.waset.org/abstracts/search?q=hypolipidemic" title=" hypolipidemic"> hypolipidemic</a>, <a href="https://publications.waset.org/abstracts/search?q=cholesterol" title=" cholesterol"> cholesterol</a> </p> <a href="https://publications.waset.org/abstracts/143289/antidiabetic-and-antihyperlipaemic-effects-of-aqueous-neem-azadirachta-indica-extract-on-alloxan-diabetic-rabbits" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143289.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">265</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14745</span> Formulation and Evaluation of Metformin Hydrochloride Microparticles via BÜCHI Nano-Spray Dryer B-90</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tamer%20Shehata">Tamer Shehata</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recently, nanotechnology acquired a great interest in the field of pharmaceutical production. Several pharmaceutical equipment were introduced into the research field for production of nanoparticles, among them, BÜCHI’ fourth generation nano-spray dryer B-90. B-90 is specialized with single step of production and drying of nano and microparticles. Currently, our research group is investigating several pharmaceutical formulations utilizing BÜCHI Nano-Spray Dryer B-90 technology. One of our projects is the formulation and evaluation of metformin hydrochloride mucoadhesive microparticles for treatment of type 2-diabetis. Several polymers were investigated, among them, gelatin and sodium alginate. The previous polymers are natural polymers with mucoadhesive properties. Preformulation studies such as atomization head mesh size, flow rate, head temperature, polymer solution viscosity and surface tension were performed. Postformulation characters such as particle size, flowability, surface scan and dissolution profile were evaluated. Finally, the pharmacological activity of certain selected formula was evaluated in streptozotocin-induced diabetic rats. B-90’spray head was 7 µm hole heated to 120 with air flow rate 3.5 mL/min. The viscosity of the solution was less than 11.5 cP with surface tension less than 70.1 dyne/cm. Successfully, discrete, non-aggregated particles and free flowing powders with particle size was less than 2000 nm were obtained. Gelatin and Sodium alginate combination in ratio 1:3 were successfully sustained the in vitro release profile of the drug. Hypoglycemic evaluation of the previous formula showed a significant reduction of blood glucose level over 24 h. In conclusion, mucoadhesive metformin hydrochloride microparticles obtained from B-90 could offer a convenient dosage form with enhanced hypoglycemic activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mucoadhesive" title="mucoadhesive">mucoadhesive</a>, <a href="https://publications.waset.org/abstracts/search?q=microparticles" title=" microparticles"> microparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=metformin%20hydrochloride" title=" metformin hydrochloride"> metformin hydrochloride</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-spray%20dryer" title=" nano-spray dryer"> nano-spray dryer</a> </p> <a href="https://publications.waset.org/abstracts/62255/formulation-and-evaluation-of-metformin-hydrochloride-microparticles-via-buchi-nano-spray-dryer-b-90" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62255.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">311</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14744</span> Cedrela Toona Roxb.: An Exploratory Study Describing Its Antidiabetic Property</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kinjal%20H.%20Shah">Kinjal H. Shah</a>, <a href="https://publications.waset.org/abstracts/search?q=Piyush%20M.%20Patel"> Piyush M. Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus is considered to be a serious endocrine syndrome. Synthetic hypoglycemic agents can produce serious side effects including hematological effects, coma, and disturbances of the liver and kidney. In addition, they are not suitable for use during pregnancy. In recent years, there have been relatively few reports of short-term side effects or toxicity due to sulphonylureas. Published figures and frequency of side effects in large series of patient range from about 1 to 5%, with symptoms severe enough to lead to the withdrawal of the drug in less than 1 to 2%. Adverse effects, in general, have been of the following type: allergic skin reactions, gastrointestinal disturbances, blood dyscrasias, hepatic dysfunction, and hypoglycemia. The associated disadvantages with insulin and oral hypoglycemic agents have led to stimulation in the research for locating natural resources showing antidiabetic activity and to explore the possibilities of using traditional medicines with proper chemical and pharmacological profiles. Literature survey reveals that the inhabitants of Abbottabad district of Pakistan use the dried leaf powder along with table salt and water orally for treating diabetes, skin allergy, wounds and as a blood purifier, where they pronounced the plant locally as ‘Nem.' The detailed phytochemical investigation of the Cedrela toona Roxb. leaves for antidiabetic activity has not been documented. Hence, there is a need for phytochemical investigation of the leaves for antidiabetic activity. The collection of fresh leaves and authentification followed by successive extraction, phytochemical screening, and testing of antidiabetic activity. The blood glucose level was reduced maximum in ethanol extract at 5th and 7th h after treatment. Blood glucose was depressed by 8.2% and 10.06% in alloxan – induced diabetic rats after treatment which was comparable to the standard drug, Glibenclamide. This may be due to the activation of the existing pancreatic cells in diabetic rats by the ethanolic extract. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antidiabetic" title="antidiabetic">antidiabetic</a>, <a href="https://publications.waset.org/abstracts/search?q=Cedrela%20toona%20Roxb." title=" Cedrela toona Roxb."> Cedrela toona Roxb.</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemical%20screening" title=" phytochemical screening"> phytochemical screening</a>, <a href="https://publications.waset.org/abstracts/search?q=blood%20glucose" title=" blood glucose"> blood glucose</a> </p> <a href="https://publications.waset.org/abstracts/65846/cedrela-toona-roxb-an-exploratory-study-describing-its-antidiabetic-property" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65846.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">260</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14743</span> Study the Effect of Lipoid Acid as a Protective Against Rheumatoid Arthritis Through Diminishing Pro-inflammatory Markers and Chemokine Expression</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khairy%20Mohamed%20Abdalla%20Zoheir">Khairy Mohamed Abdalla Zoheir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the most severe complications of Rheumatoid arthritis is delayed recovery. lipoic acid possesses antioxidant, hypoglycemic, and anti-inflammatory activity. In the present study, the effects of lipoic acid were investigated on the key mediators of Rheumatoid arthritis, namely, CD4+CD25+ T cell subsets, GITR expressing cells, CD4+CD25+Foxp3+ regulatory T (Treg) cells, T-helper-17 (Th17) cells and pro-inflammatory cytokines Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumor Necrosis Factor- α (TNF-α)] through flow-cytometry and qPCR analyses. Lipoic acid-treated mice showed a significant decrease in Rheumatoid arthritis, the frequency of GITR-expressing cells, and Th1 cytokines (IL-17A, TNF-αand Interferon- γ (IFN-γ) compared with positive and negative controlled mice. Lipoic acid treatment also downregulated the mRNA expression of the inflammatory mediators compared with the Rheumatoid arthritis mouse model and untreated mice. The number of Tregs was also found to be significantly upregulated in lipoic acid-treated mice. Our results were confirmed by the histopathological examination. This study showed the beneficial role of lipoic acid in promoting a well-balanced tool for the therapy of Rheumatoid arthritis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lipoic%20acid" title="lipoic acid">lipoic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=inflammatory%20markers" title=" inflammatory markers"> inflammatory markers</a>, <a href="https://publications.waset.org/abstracts/search?q=rheumatoid%20arthritis" title=" rheumatoid arthritis"> rheumatoid arthritis</a>, <a href="https://publications.waset.org/abstracts/search?q=qPCR" title=" qPCR"> qPCR</a> </p> <a href="https://publications.waset.org/abstracts/158873/study-the-effect-of-lipoid-acid-as-a-protective-against-rheumatoid-arthritis-through-diminishing-pro-inflammatory-markers-and-chemokine-expression" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158873.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14742</span> Biochemical Studies on the Effects of Cymbopogon citratus (Lemon Grass) on Wistar Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adegbegi%20Ademuyiwa%20Joshua">Adegbegi Ademuyiwa Joshua</a>, <a href="https://publications.waset.org/abstracts/search?q=Onoagbe%20Iyare"> Onoagbe Iyare</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Medicinal plants have been recognized to have therapeutic effects and they may also have toxic side effects. The present study was undertaken to investigate the effect of extracts of Cymbopogon citratus on normal rats. Blood glucose levels of all animals were determined. Biochemical studies carried out to determine the oxidative status by measuring activities of superoxide dismutase (SOD) and catalase (CAT), and in the liver, kidney and pancrease. Oral administration of ethanolic and aqueous extract of C. citratus at a doses of 200 mg/kg body weight, for a period of 30 days, caused a significant (p<0.05) reduction in blood glucose levels. Effect on hormonal profile (TSH, T3, and T4) was also determined, and was found to be significantly higher in all the administered groups when compared with control. Lipid profiles levels; Total cholesterols, triglycerides, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol were significantly (p>0.05) higher for all treated rats as compared against control. SOD, catalase, GSH and Vitamin C activities in the tissues (liver, kidney and pancrease) of the rats treated with the medicinal plants were generally higher or statistical slightly similar to control. Histopathology result showed that both ethanolic and aqueous extracts (200 mg/kg body weight) of C. citratus was safer as no adverse effects were observed in the organs examined. Findings in this study showed that this plant has hypoglycemic properties and did not exert oxidative damage; in some instances, particularly in the liver, kidney and pancreas as well as its relative safety and possible use for weight gain. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plants" title="medicinal plants">medicinal plants</a>, <a href="https://publications.waset.org/abstracts/search?q=blood%20glucose" title=" blood glucose"> blood glucose</a>, <a href="https://publications.waset.org/abstracts/search?q=cymbopogon%20citratus" title=" cymbopogon citratus"> cymbopogon citratus</a>, <a href="https://publications.waset.org/abstracts/search?q=hypoglycaemic" title=" hypoglycaemic"> hypoglycaemic</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20status" title=" oxidative status"> oxidative status</a> </p> <a href="https://publications.waset.org/abstracts/28326/biochemical-studies-on-the-effects-of-cymbopogon-citratus-lemon-grass-on-wistar-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28326.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">472</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20effect&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=hypoglycemic%20effect&page=3">3</a></li> <li class="page-item"><a class="page-link" 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