CINXE.COM

<!DOCTYPE html><html data-capo=""><head><meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1"> <script id="CookieBot" src="https://consent.cookiebot.com/uc.js?cbid=6b5b25c6-89f0-4619-834a-8af9d1157dc1" async type="text/javascript"></script> <link rel="preconnect" href="https://pub.mdpi-res.com" crossorigin> <link rel="stylesheet" href="https://pub.mdpi-res.com/assets/fonts/suisse/fonts.css" media="all"> <style>/*! tailwindcss v3.3.2 | MIT License | https://tailwindcss.com*/*,:after,:before{border:0 solid;box-sizing:border-box}:after,:before{--tw-content:""}html{line-height:1.5;-webkit-text-size-adjust:100%;font-family:Suisse Int\'l,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji;font-feature-settings:normal;font-variation-settings:normal;tab-size:4}body{line-height:inherit;margin:0}hr{border-top-width:1px;color:inherit;height:0}abbr:where([title]){-webkit-text-decoration:underline dotted;text-decoration:underline dotted}h1,h2,h3,h4,h5,h6{font-size:inherit;font-weight:inherit}a{color:inherit;text-decoration:inherit}b,strong{font-weight:bolder}code,kbd,pre,samp{font-family:ui-monospace,SFMono-Regular,Menlo,Monaco,Consolas,Liberation Mono,Courier New,monospace;font-size:1em}small{font-size:80%}sub,sup{font-size:75%;line-height:0;position:relative;vertical-align:initial}sub{bottom:-.25em}sup{top:-.5em}table{border-collapse:collapse;border-color:inherit;text-indent:0}button,input,optgroup,select,textarea{color:inherit;font-family:inherit;font-size:100%;font-weight:inherit;line-height:inherit;margin:0;padding:0}button,select{text-transform:none}[type=button],[type=reset],[type=submit],button{-webkit-appearance:button;background-color:initial;background-image:none}:-moz-focusring{outline:auto}:-moz-ui-invalid{box-shadow:none}progress{vertical-align:initial}::-webkit-inner-spin-button,::-webkit-outer-spin-button{height:auto}[type=search]{-webkit-appearance:textfield;outline-offset:-2px}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-file-upload-button{-webkit-appearance:button;font:inherit}summary{display:list-item}blockquote,dd,dl,figure,h1,h2,h3,h4,h5,h6,hr,p,pre{margin:0}fieldset{margin:0}fieldset,legend{padding:0}menu,ol,ul{list-style:none;margin:0;padding:0}textarea{resize:vertical}input::placeholder,textarea::placeholder{color:#9ca3af;opacity:1}[role=button],button{cursor:pointer}:disabled{cursor:default}audio,canvas,embed,iframe,img,object,svg,video{display:block;vertical-align:middle}img,video{height:auto;max-width:100%}[hidden]{display:none}html{color:var(--color-text-default)}*,::backdrop,:after,:before{--tw-border-spacing-x:0;--tw-border-spacing-y:0;--tw-translate-x:0;--tw-translate-y:0;--tw-rotate:0;--tw-skew-x:0;--tw-skew-y:0;--tw-scale-x:1;--tw-scale-y:1;--tw-pan-x: ;--tw-pan-y: ;--tw-pinch-zoom: ;--tw-scroll-snap-strictness:proximity;--tw-gradient-from-position: ;--tw-gradient-via-position: ;--tw-gradient-to-position: ;--tw-ordinal: ;--tw-slashed-zero: ;--tw-numeric-figure: ;--tw-numeric-spacing: ;--tw-numeric-fraction: ;--tw-ring-inset: ;--tw-ring-offset-width:0px;--tw-ring-offset-color:#fff;--tw-ring-color:#3b82f680;--tw-ring-offset-shadow:0 0 #0000;--tw-ring-shadow:0 0 #0000;--tw-shadow:0 0 #0000;--tw-shadow-colored:0 0 #0000;--tw-blur: ;--tw-brightness: ;--tw-contrast: ;--tw-grayscale: ;--tw-hue-rotate: ;--tw-invert: ;--tw-saturate: ;--tw-sepia: ;--tw-drop-shadow: ;--tw-backdrop-blur: ;--tw-backdrop-brightness: ;--tw-backdrop-contrast: ;--tw-backdrop-grayscale: ;--tw-backdrop-hue-rotate: ;--tw-backdrop-invert: ;--tw-backdrop-opacity: ;--tw-backdrop-saturate: ;--tw-backdrop-sepia: }.container{width:100%}@media (min-width:576px){.container{max-width:576px}}@media (min-width:768px){.container{max-width:768px}}@media (min-width:1024px){.container{max-width:1024px}}@media (min-width:1280px){.container{max-width:1280px}}@media (min-width:1440px){.container{max-width:1440px}}@media (min-width:1920px){.container{max-width:1920px}}.prose{color:var(--tw-prose-body);max-width:65ch}.prose :where(p):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em;margin-top:1.25em}.prose :where([class~=lead]):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-lead);font-size:1.25em;line-height:1.6;margin-bottom:1.2em;margin-top:1.2em}.prose :where(a):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-links);font-weight:500;text-decoration:underline}.prose :where(strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-bold);font-weight:600}.prose :where(a strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(blockquote strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(thead th strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(ol):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:decimal;margin-bottom:1.25em;margin-top:1.25em;padding-inline-start:1.625em}.prose :where(ol[type=A]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-alpha}.prose :where(ol[type=a]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-alpha}.prose :where(ol[type=A s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-alpha}.prose :where(ol[type=a s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-alpha}.prose :where(ol[type=I]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-roman}.prose :where(ol[type=i]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-roman}.prose :where(ol[type=I s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-roman}.prose :where(ol[type=i s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-roman}.prose :where(ol[type="1"]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:decimal}.prose :where(ul):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:disc;margin-bottom:1.25em;margin-top:1.25em;padding-inline-start:1.625em}.prose :where(ol>li):not(:where([class~=not-prose],[class~=not-prose] *))::marker{color:var(--tw-prose-counters);font-weight:400}.prose :where(ul>li):not(:where([class~=not-prose],[class~=not-prose] *))::marker{color:var(--tw-prose-bullets)}.prose :where(dt):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-weight:600;margin-top:1.25em}.prose :where(hr):not(:where([class~=not-prose],[class~=not-prose] *)){border-color:var(--tw-prose-hr);border-top-width:1px;margin-bottom:3em;margin-top:3em}.prose :where(blockquote):not(:where([class~=not-prose],[class~=not-prose] *)){border-inline-start-color:var(--tw-prose-quote-borders);border-inline-start-width:.25rem;color:var(--tw-prose-quotes);font-style:italic;font-weight:500;margin-bottom:1.6em;margin-top:1.6em;padding-inline-start:1em;quotes:"\201C""\201D""\2018""\2019"}.prose :where(blockquote p:first-of-type):not(:where([class~=not-prose],[class~=not-prose] *)):before{content:open-quote}.prose :where(blockquote p:last-of-type):not(:where([class~=not-prose],[class~=not-prose] *)):after{content:close-quote}.prose :where(h1):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-size:2.25em;font-weight:800;line-height:1.1111111;margin-bottom:.8888889em;margin-top:0}.prose :where(h1 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:900}.prose :where(h2):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-size:1.5em;font-weight:700;line-height:1.3333333;margin-bottom:1em;margin-top:2em}.prose :where(h2 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:800}.prose :where(h3):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-size:1.25em;font-weight:600;line-height:1.6;margin-bottom:.6em;margin-top:1.6em}.prose :where(h3 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:700}.prose :where(h4):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-weight:600;line-height:1.5;margin-bottom:.5em;margin-top:1.5em}.prose :where(h4 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:700}.prose :where(img):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:2em;margin-top:2em}.prose :where(picture):not(:where([class~=not-prose],[class~=not-prose] *)){display:block;margin-bottom:2em;margin-top:2em}.prose :where(video):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:2em;margin-top:2em}.prose :where(kbd):not(:where([class~=not-prose],[class~=not-prose] *)){border-radius:.3125rem;box-shadow:0 0 0 1px rgb(var(--tw-prose-kbd-shadows)/10%),0 3px 0 rgb(var(--tw-prose-kbd-shadows)/10%);color:var(--tw-prose-kbd);font-family:inherit;font-size:.875em;font-weight:500;padding-inline-end:.375em;padding-bottom:.1875em;padding-top:.1875em;padding-inline-start:.375em}.prose :where(code):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-code);font-size:.875em;font-weight:600}.prose :where(code):not(:where([class~=not-prose],[class~=not-prose] *)):before{content:"`"}.prose :where(code):not(:where([class~=not-prose],[class~=not-prose] *)):after{content:"`"}.prose :where(a code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(h1 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(h2 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-size:.875em}.prose :where(h3 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-size:.9em}.prose :where(h4 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(blockquote code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(thead th code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(pre):not(:where([class~=not-prose],[class~=not-prose] *)){background-color:var(--tw-prose-pre-bg);border-radius:.375rem;color:var(--tw-prose-pre-code);font-size:.875em;font-weight:400;line-height:1.7142857;margin-bottom:1.7142857em;margin-top:1.7142857em;overflow-x:auto;padding-inline-end:1.1428571em;padding-bottom:.8571429em;padding-top:.8571429em;padding-inline-start:1.1428571em}.prose :where(pre code):not(:where([class~=not-prose],[class~=not-prose] *)){background-color:initial;border-radius:0;border-width:0;color:inherit;font-family:inherit;font-size:inherit;font-weight:inherit;line-height:inherit;padding:0}.prose :where(pre code):not(:where([class~=not-prose],[class~=not-prose] *)):before{content:none}.prose :where(pre code):not(:where([class~=not-prose],[class~=not-prose] *)):after{content:none}.prose :where(table):not(:where([class~=not-prose],[class~=not-prose] *)){font-size:.875em;line-height:1.7142857;margin-bottom:2em;margin-top:2em;table-layout:auto;width:100%}.prose :where(thead):not(:where([class~=not-prose],[class~=not-prose] *)){border-bottom-color:var(--tw-prose-th-borders);border-bottom-width:1px}.prose :where(thead th):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-weight:600;padding-inline-end:.5714286em;padding-bottom:.5714286em;padding-inline-start:.5714286em;vertical-align:bottom}.prose :where(tbody tr):not(:where([class~=not-prose],[class~=not-prose] *)){border-bottom-color:var(--tw-prose-td-borders);border-bottom-width:1px}.prose :where(tbody tr:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){border-bottom-width:0}.prose :where(tbody td):not(:where([class~=not-prose],[class~=not-prose] *)){vertical-align:initial}.prose :where(tfoot):not(:where([class~=not-prose],[class~=not-prose] *)){border-top-color:var(--tw-prose-th-borders);border-top-width:1px}.prose :where(tfoot td):not(:where([class~=not-prose],[class~=not-prose] *)){vertical-align:top}.prose :where(th,td):not(:where([class~=not-prose],[class~=not-prose] *)){text-align:start}.prose :where(figure>*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:0;margin-top:0}.prose :where(figcaption):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-captions);font-size:.875em;line-height:1.4285714;margin-top:.8571429em}.prose{--tw-prose-body:#374151;--tw-prose-headings:#111827;--tw-prose-lead:#4b5563;--tw-prose-links:#111827;--tw-prose-bold:#111827;--tw-prose-counters:#6b7280;--tw-prose-bullets:#d1d5db;--tw-prose-hr:#e5e7eb;--tw-prose-quotes:#111827;--tw-prose-quote-borders:#e5e7eb;--tw-prose-captions:#6b7280;--tw-prose-kbd:#111827;--tw-prose-kbd-shadows:17 24 39;--tw-prose-code:#111827;--tw-prose-pre-code:#e5e7eb;--tw-prose-pre-bg:#1f2937;--tw-prose-th-borders:#d1d5db;--tw-prose-td-borders:#e5e7eb;--tw-prose-invert-body:#d1d5db;--tw-prose-invert-headings:#fff;--tw-prose-invert-lead:#9ca3af;--tw-prose-invert-links:#fff;--tw-prose-invert-bold:#fff;--tw-prose-invert-counters:#9ca3af;--tw-prose-invert-bullets:#4b5563;--tw-prose-invert-hr:#374151;--tw-prose-invert-quotes:#f3f4f6;--tw-prose-invert-quote-borders:#374151;--tw-prose-invert-captions:#9ca3af;--tw-prose-invert-kbd:#fff;--tw-prose-invert-kbd-shadows:255 255 255;--tw-prose-invert-code:#fff;--tw-prose-invert-pre-code:#d1d5db;--tw-prose-invert-pre-bg:#00000080;--tw-prose-invert-th-borders:#4b5563;--tw-prose-invert-td-borders:#374151;font-size:1rem;line-height:1.75}.prose :where(picture>img):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:0;margin-top:0}.prose :where(li):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:.5em;margin-top:.5em}.prose :where(ol>li):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:.375em}.prose :where(ul>li):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:.375em}.prose :where(.prose>ul>li p):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:.75em;margin-top:.75em}.prose :where(.prose>ul>li>p:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:1.25em}.prose :where(.prose>ul>li>p:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em}.prose :where(.prose>ol>li>p:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:1.25em}.prose :where(.prose>ol>li>p:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em}.prose :where(ul ul,ul ol,ol ul,ol ol):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:.75em;margin-top:.75em}.prose :where(dl):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em;margin-top:1.25em}.prose :where(dd):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:.5em;padding-inline-start:1.625em}.prose :where(hr+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(h2+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(h3+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(h4+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(thead th:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:0}.prose :where(thead th:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-end:0}.prose :where(tbody td,tfoot td):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-end:.5714286em;padding-bottom:.5714286em;padding-top:.5714286em;padding-inline-start:.5714286em}.prose :where(tbody td:first-child,tfoot td:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:0}.prose :where(tbody td:last-child,tfoot td:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-end:0}.prose :where(figure):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:2em;margin-top:2em}.prose :where(.prose>:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(.prose>:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:0}.sr-only{height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;clip:rect(0,0,0,0);border-width:0;white-space:nowrap}.pointer-events-none{pointer-events:none}.visible{visibility:visible}.invisible{visibility:hidden}.collapse{visibility:collapse}.static{position:static}.fixed{position:fixed}.\!absolute{position:absolute!important}.absolute{position:absolute}.relative{position:relative}.sticky{position:sticky}.inset-0{inset:0}.inset-y-0{bottom:0;top:0}.-top-px{top:-1px}.bottom-0{bottom:0}.bottom-1{bottom:.25rem}.bottom-1\.5{bottom:.375rem}.bottom-10{bottom:2.5rem}.bottom-24{bottom:6rem}.bottom-4{bottom:1rem}.bottom-6{bottom:1.5rem}.bottom-\[7\.5rem\]{bottom:7.5rem}.bottom-md{bottom:var(--spacing-md)}.left-0{left:0}.left-1\/2{left:50%}.left-12{left:3rem}.left-4{left:1rem}.left-6{left:1.5rem}.left-md{left:var(--spacing-md)}.right-0{right:0}.right-1{right:.25rem}.right-1\.5{right:.375rem}.right-12{right:3rem}.right-2{right:.5rem}.right-2\.5{right:.625rem}.right-4{right:1rem}.right-6{right:1.5rem}.right-8{right:2rem}.right-\[-10px\]{right:-10px}.right-\[-4px\]{right:-4px}.right-\[-8px\]{right:-8px}.right-\[1rem\]{right:1rem}.right-\[3\.125rem\]{right:3.125rem}.top-0{top:0}.top-1{top:.25rem}.top-1\/2{top:50%}.top-12{top:3rem}.top-14{top:3.5rem}.top-16{top:4rem}.top-20{top:5rem}.top-4{top:1rem}.top-6{top:1.5rem}.top-\[-4px\]{top:-4px}.top-\[-5\.875rem\]{top:-5.875rem}.top-\[4\.625rem\]{top:4.625rem}.top-\[48\%\]{top:48%}.top-\[calc$50vh\+15rem$\]{top:calc(50vh + 15rem)}.top-\[calc$50vh\+6\.25rem$\]{top:calc(50vh + 6.25rem)}.isolate{isolation:isolate}.-z-10{z-index:-10}.z-0{z-index:0}.z-1{z-index:1}.z-10{z-index:10}.z-20{z-index:20}.z-40{z-index:40}.z-50{z-index:50}.float-left{float:left}.clear-left{clear:left}.m-0{margin:0}.m-\[\.625rem\]{margin:.625rem}.m-auto{margin:auto}.m-md{margin:var(--spacing-md)}.mx-auto{margin-left:auto;margin-right:auto}.mx-lg{margin-left:var(--spacing-lg);margin-right:var(--spacing-lg)}.mx-md{margin-left:var(--spacing-md);margin-right:var(--spacing-md)}.mx-sm{margin-left:var(--spacing-sm);margin-right:var(--spacing-sm)}.my-0{margin-bottom:0;margin-top:0}.my-2xl{margin-bottom:var(--spacing-2xl);margin-top:var(--spacing-2xl)}.my-4{margin-bottom:1rem;margin-top:1rem}.my-5xl{margin-bottom:var(--spacing-5xl);margin-top:var(--spacing-5xl)}.my-lg{margin-bottom:var(--spacing-lg);margin-top:var(--spacing-lg)}.my-md{margin-bottom:var(--spacing-md);margin-top:var(--spacing-md)}.my-sm{margin-bottom:var(--spacing-sm);margin-top:var(--spacing-sm)}.my-xl{margin-bottom:var(--spacing-xl);margin-top:var(--spacing-xl)}.-mr-0{margin-right:0}.-mr-0\.5{margin-right:-.125rem}.-mr-1{margin-right:-.25rem}.-mr-2{margin-right:-.5rem}.-mr-2\.5{margin-right:-.625rem}.-mt-xs{margin-top:calc(var(--spacing-xs)*-1)}.mb-1{margin-bottom:.25rem}.mb-2{margin-bottom:.5rem}.mb-2xl{margin-bottom:var(--spacing-2xl)}.mb-3{margin-bottom:.75rem}.mb-4{margin-bottom:1rem}.mb-6{margin-bottom:1.5rem}.mb-7xl{margin-bottom:var(--spacing-7xl)}.mb-\[0\.25rem\]{margin-bottom:.25rem}.mb-lg{margin-bottom:var(--spacing-lg)}.mb-md{margin-bottom:var(--spacing-md)}.mb-sm{margin-bottom:var(--spacing-sm)}.mb-xl{margin-bottom:var(--spacing-xl)}.mb-xs{margin-bottom:var(--spacing-xs)}.ml-2{margin-left:.5rem}.ml-2xl{margin-left:var(--spacing-2xl)}.ml-\[-0\.0625rem\]{margin-left:-.0625rem}.ml-\[-0\.75rem\]{margin-left:-.75rem}.ml-\[0\.625rem\]{margin-left:.625rem}.ml-\[0\.75rem\]{margin-left:.75rem}.ml-auto{margin-left:auto}.ml-lg{margin-left:var(--spacing-lg)}.ml-md{margin-left:var(--spacing-md)}.ml-sm{margin-left:var(--spacing-sm)}.ml-xs{margin-left:var(--spacing-xs)}.mr-4{margin-right:1rem}.mr-5{margin-right:1.25rem}.mr-6{margin-right:1.5rem}.mr-\[\.125rem\]{margin-right:.125rem}.mr-\[\.625rem\]{margin-right:.625rem}.mr-\[0\.3125rem\]{margin-right:.3125rem}.mr-\[2\.3125rem\]{margin-right:2.3125rem}.mr-\[2\.375rem\]{margin-right:2.375rem}.mr-\[5\.625rem\]{margin-right:5.625rem}.mr-lg{margin-right:var(--spacing-lg)}.mr-md{margin-right:var(--spacing-md)}.mr-sm{margin-right:var(--spacing-sm)}.mr-xl{margin-right:var(--spacing-xl)}.mr-xs{margin-right:var(--spacing-xs)}.mt-1{margin-top:.25rem}.mt-2xl{margin-top:var(--spacing-2xl)}.mt-3xl{margin-top:var(--spacing-3xl)}.mt-6{margin-top:1.5rem}.mt-\[-3rem\]{margin-top:-3rem}.mt-\[\.625rem\]{margin-top:.625rem}.mt-\[1\.25rem\]{margin-top:1.25rem}.mt-\[1rem\]{margin-top:1rem}.mt-lg{margin-top:var(--spacing-lg)}.mt-md{margin-top:var(--spacing-md)}.mt-sm{margin-top:var(--spacing-sm)}.mt-xl{margin-top:var(--spacing-xl)}.mt-xs{margin-top:var(--spacing-xs)}.box-border{box-sizing:border-box}.line-clamp-1{-webkit-line-clamp:1}.line-clamp-1,.line-clamp-3{display:-webkit-box;overflow:hidden;-webkit-box-orient:vertical}.line-clamp-3{-webkit-line-clamp:3}.\!block{display:block!important}.block{display:block}.\!inline-block{display:inline-block!important}.inline-block{display:inline-block}.\!inline{display:inline!important}.inline{display:inline}.flex{display:flex}.\!inline-flex{display:inline-flex!important}.inline-flex{display:inline-flex}.table{display:table}.grid{display:grid}.contents{display:contents}.\!hidden{display:none!important}.hidden{display:none}.aspect-\[1\/1\.414\]{aspect-ratio:1/1.414}.aspect-\[1200\/630\]{aspect-ratio:1200/630}.aspect-\[381\/200\]{aspect-ratio:381/200}.aspect-\[4\/5\]{aspect-ratio:4/5}.aspect-square{aspect-ratio:1/1}.aspect-video{aspect-ratio:16/9}.\!h-6{height:1.5rem!important}.h-0{height:0}.h-0\.5{height:.125rem}.h-1{height:.25rem}.h-1\.5{height:.375rem}.h-10{height:2.5rem}.h-12{height:3rem}.h-14{height:3.5rem}.h-16{height:4rem}.h-2{height:.5rem}.h-20{height:5rem}.h-28{height:7rem}.h-3{height:.75rem}.h-32{height:8rem}.h-36{height:9rem}.h-4{height:1rem}.h-48{height:12rem}.h-5{height:1.25rem}.h-52{height:13rem}.h-6{height:1.5rem}.h-7{height:1.75rem}.h-8{height:2rem}.h-80{height:20rem}.h-9{height:2.25rem}.h-96{height:24rem}.h-\[\.25rem\]{height:.25rem}.h-\[0\.5rem\]{height:.5rem}.h-\[0\.9rem\]{height:.9rem}.h-\[1\.15em\]{height:1.15em}.h-\[1\.3rem\]{height:1.3rem}.h-\[1\.4rem\]{height:1.4rem}.h-\[1\.5rem\]{height:1.5rem}.h-\[1\.8125rem\]{height:1.8125rem}.h-\[1\.875rem\]{height:1.875rem}.h-\[100\%\]{height:100%}.h-\[100px\]{height:100px}.h-\[150px\]{height:150px}.h-\[160px\]{height:160px}.h-\[1rem\]{height:1rem}.h-\[2\.5rem\]{height:2.5rem}.h-\[24rem\]{height:24rem}.h-\[25\.25rem\]{height:25.25rem}.h-\[3\.625rem\]{height:3.625rem}.h-\[3\.75rem\]{height:3.75rem}.h-\[30rem\]{height:30rem}.h-\[35\.5rem\]{height:35.5rem}.h-\[38rem\]{height:38rem}.h-\[4\.5rem\]{height:4.5rem}.h-\[50rem\]{height:50rem}.h-\[5rem\]{height:5rem}.h-\[6\.5rem\]{height:6.5rem}.h-\[6px\]{height:6px}.h-\[auto\],.h-auto{height:auto}.h-fit{height:fit-content}.h-full{height:100%}.h-px{height:1px}.max-h-60{max-height:15rem}.max-h-80{max-height:20rem}.min-h-\[1\.5rem\]{min-height:1.5rem}.min-h-\[100px\]{min-height:100px}.min-h-\[15vh\]{min-height:15vh}.min-h-\[45rem\]{min-height:45rem}.min-h-\[70vh\]{min-height:70vh}.min-h-full{min-height:100%}.\!w-2xl{width:var(--spacing-2xl)!important}.\!w-40{width:10rem!important}.\!w-fit{width:fit-content!important}.\!w-full{width:100%!important}.w-1{width:.25rem}.w-1\.5{width:.375rem}.w-1\/2{width:50%}.w-1\/4{width:25%}.w-1\/5{width:20%}.w-10{width:2.5rem}.w-12{width:3rem}.w-14{width:3.5rem}.w-16{width:4rem}.w-2{width:.5rem}.w-20{width:5rem}.w-28{width:7rem}.w-3{width:.75rem}.w-3\/5{width:60%}.w-32{width:8rem}.w-36{width:9rem}.w-4{width:1rem}.w-4\/5{width:80%}.w-40{width:10rem}.w-4xl{width:var(--spacing-4xl)}.w-5{width:1.25rem}.w-6{width:1.5rem}.w-60{width:15rem}.w-7{width:1.75rem}.w-8{width:2rem}.w-80{width:20rem}.w-9{width:2.25rem}.w-96{width:24rem}.w-\[\.25rem\]{width:.25rem}.w-\[1\.15em\]{width:1.15em}.w-\[1\.4rem\]{width:1.4rem}.w-\[1\.5rem\]{width:1.5rem}.w-\[1\.6rem\]{width:1.6rem}.w-\[10\%\]{width:10%}.w-\[10\.25rem\]{width:10.25rem}.w-\[10\.625rem\]{width:10.625rem}.w-\[100\%\]{width:100%}.w-\[10rem\]{width:10rem}.w-\[13\.125rem\]{width:13.125rem}.w-\[13rem\]{width:13rem}.w-\[15\%\]{width:15%}.w-\[18rem\]{width:18rem}.w-\[1rem\]{width:1rem}.w-\[2\.5rem\]{width:2.5rem}.w-\[2\.75rem\]{width:2.75rem}.w-\[20\%\]{width:20%}.w-\[22px\]{width:22px}.w-\[25rem\]{width:25rem}.w-\[30\%\]{width:30%}.w-\[33\%\]{width:33%}.w-\[4\.5rem\]{width:4.5rem}.w-\[6\.5rem\]{width:6.5rem}.w-\[6\.75rem\]{width:6.75rem}.w-\[7\.5rem\]{width:7.5rem}.w-\[92\.5vw\]{width:92.5vw}.w-auto{width:auto}.w-fit{width:fit-content}.w-full{width:100%}.w-max{width:max-content}.w-min{width:min-content}.w-px{width:1px}.w-screen{width:100vw}.\!min-w-0{min-width:0!important}.min-w-10{min-width:2.5rem}.min-w-12{min-width:3rem}.min-w-14{min-width:3.5rem}.min-w-28{min-width:7rem}.min-w-5{min-width:1.25rem}.min-w-6{min-width:1.5rem}.min-w-7{min-width:1.75rem}.min-w-8{min-width:2rem}.min-w-\[0\.5rem\]{min-width:.5rem}.min-w-\[0\.9rem\]{min-width:.9rem}.min-w-\[1\.3rem\]{min-width:1.3rem}.min-w-\[12\.5rem\]{min-width:12.5rem}.min-w-\[146px\]{min-width:146px}.min-w-\[156px\]{min-width:156px}.min-w-\[21rem\]{min-width:21rem}.min-w-\[3\.75rem\]{min-width:3.75rem}.min-w-\[4\.5rem\]{min-width:4.5rem}.min-w-\[6\.5rem\]{min-width:6.5rem}.min-w-fit{min-width:fit-content}.max-w-\[100\%\]{max-width:100%}.max-w-\[20rem\]{max-width:20rem}.max-w-\[25rem\]{max-width:25rem}.max-w-\[28\.5rem\]{max-width:28.5rem}.max-w-\[30\%\]{max-width:30%}.max-w-\[5rem\]{max-width:5rem}.max-w-\[6px\]{max-width:6px}.max-w-\[80\%\]{max-width:80%}.max-w-\[90rem\]{max-width:90rem}.max-w-\[96\%\]{max-width:96%}.max-w-\[98vw\]{max-width:98vw}.max-w-full{max-width:100%}.max-w-prose{max-width:65ch}.max-w-sm{max-width:24rem}.max-w-xs{max-width:20rem}.\!flex-none{flex:none!important}.flex-1{flex:1 1 0%}.flex-\[1\]{flex:1}.flex-\[2\]{flex:2}.flex-\[3\]{flex:3}.flex-auto{flex:1 1 auto}.flex-none{flex:none}.flex-shrink-0,.shrink-0{flex-shrink:0}.shrink-\[14\]{flex-shrink:14}.grow{flex-grow:1}.grow-\[2\]{flex-grow:2}.basis-6{flex-basis:1.5rem}.origin-bottom{transform-origin:bottom}.origin-bottom-left{transform-origin:bottom left}.origin-bottom-right{transform-origin:bottom right}.origin-center{transform-origin:center}.origin-left{transform-origin:left}.origin-right{transform-origin:right}.origin-top{transform-origin:top}.origin-top-left{transform-origin:top left}.origin-top-right{transform-origin:top right}.-translate-x-1\/2{--tw-translate-x:-50%;transform:translate(-50%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-x-full{--tw-translate-x:-100%;transform:translate(-100%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-1\/2{--tw-translate-y:-50%;transform:translate(var(--tw-translate-x),-50%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-2{--tw-translate-y:-0.5rem;transform:translate(var(--tw-translate-x),-.5rem) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-4{--tw-translate-y:-1rem;transform:translate(var(--tw-translate-x),-1rem) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-\[calc$100\%\+0\.25rem$\]{--tw-translate-y:calc(-100% + -0.25rem);transform:translate(var(--tw-translate-x),calc(-100% + -.25rem)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-full{--tw-translate-y:-100%;transform:translate(var(--tw-translate-x),-100%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-0{--tw-translate-x:0px;transform:translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-0\.5{--tw-translate-x:0.125rem;transform:translate(.125rem,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-\[1\.375rem\]{--tw-translate-x:1.375rem;transform:translate(1.375rem,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-full{--tw-translate-x:100%;transform:translate(100%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-y-0{--tw-translate-y:0px;transform:translate(var(--tw-translate-x)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-y-4{--tw-translate-y:1rem;transform:translate(var(--tw-translate-x),1rem) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-y-full{--tw-translate-y:100%;transform:translate(var(--tw-translate-x),100%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.rotate-180{--tw-rotate:180deg;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(180deg) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.rotate-45{--tw-rotate:45deg;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(45deg) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.scale-100{--tw-scale-x:1;--tw-scale-y:1;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(1) scaleY(1);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.scale-95{--tw-scale-x:.95;--tw-scale-y:.95;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(.95) scaleY(.95);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.scale-\[101\.5\%\]{--tw-scale-x:101.5%;--tw-scale-y:101.5%;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(101.5%) scaleY(101.5%)}.scale-\[101\.5\%\],.transform{transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}@keyframes spin{to{transform:rotate(1turn)}}.animate-spin{animation:spin 1s linear infinite}.cursor-default{cursor:default}.cursor-move{cursor:move}.cursor-not-allowed{cursor:not-allowed}.cursor-pointer{cursor:pointer}.select-none{-webkit-user-select:none;user-select:none}.resize-none{resize:none}.resize{resize:both}.\!list-inside{list-style-position:inside!important}.list-inside{list-style-position:inside}.list-decimal{list-style-type:decimal}.list-disc{list-style-type:disc}.appearance-none{appearance:none}.grid-cols-3{grid-template-columns:repeat(3,minmax(0,1fr))}.flex-row{flex-direction:row}.flex-row-reverse{flex-direction:row-reverse}.flex-col{flex-direction:column}.flex-col-reverse{flex-direction:column-reverse}.flex-wrap{flex-wrap:wrap}.place-content-center{place-content:center}.content-center{align-content:center}.items-start{align-items:flex-start}.items-end{align-items:flex-end}.items-center{align-items:center}.items-baseline{align-items:baseline}.\!justify-start{justify-content:flex-start!important}.justify-start{justify-content:flex-start}.justify-end{justify-content:flex-end}.justify-center{justify-content:center}.\!justify-between{justify-content:space-between!important}.justify-between{justify-content:space-between}.justify-around{justify-content:space-around}.\!gap-md{gap:var(--spacing-md)!important}.gap-1{gap:.25rem}.gap-2{gap:.5rem}.gap-2\.5{gap:.625rem}.gap-3{gap:.75rem}.gap-4{gap:1rem}.gap-5{gap:1.25rem}.gap-6{gap:1.5rem}.gap-8{gap:2rem}.gap-\[0\.65em\]{gap:.65em}.gap-lg{gap:var(--spacing-lg)}.gap-md{gap:var(--spacing-md)}.gap-sm{gap:var(--spacing-sm)}.gap-xl{gap:var(--spacing-xl)}.gap-xs{gap:var(--spacing-xs)}.gap-x-1{column-gap:.25rem}.gap-x-4{column-gap:1rem}.gap-x-lg{column-gap:var(--spacing-lg)}.gap-x-sm{column-gap:var(--spacing-sm)}.gap-x-xs{column-gap:var(--spacing-xs)}.gap-y-5{row-gap:1.25rem}.gap-y-lg{row-gap:var(--spacing-lg)}.gap-y-md{row-gap:var(--spacing-md)}.gap-y-sm{row-gap:var(--spacing-sm)}.gap-y-xl{row-gap:var(--spacing-xl)}.gap-y-xs{row-gap:var(--spacing-xs)}.space-x-1>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:.25rem;margin-left:calc(.25rem*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(.25rem*var(--tw-space-x-reverse))}.space-x-5>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:1.25rem;margin-left:calc(1.25rem*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(1.25rem*var(--tw-space-x-reverse))}.space-y-1>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(.25rem*var(--tw-space-y-reverse));margin-top:.25rem;margin-top:calc(.25rem*(1 - var(--tw-space-y-reverse)))}.space-y-2>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(.5rem*var(--tw-space-y-reverse));margin-top:.5rem;margin-top:calc(.5rem*(1 - var(--tw-space-y-reverse)))}.space-y-2xl>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:calc(var(--spacing-2xl)*var(--tw-space-y-reverse));margin-top:calc(var(--spacing-2xl)*(1 - var(--tw-space-y-reverse)))}.space-y-4>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(1rem*var(--tw-space-y-reverse));margin-top:1rem;margin-top:calc(1rem*(1 - var(--tw-space-y-reverse)))}.space-y-lg>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:calc(var(--spacing-lg)*var(--tw-space-y-reverse));margin-top:calc(var(--spacing-lg)*(1 - var(--tw-space-y-reverse)))}.space-y-md>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:calc(var(--spacing-md)*var(--tw-space-y-reverse));margin-top:calc(var(--spacing-md)*(1 - var(--tw-space-y-reverse)))}.space-y-sm>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:calc(var(--spacing-sm)*var(--tw-space-y-reverse));margin-top:calc(var(--spacing-sm)*(1 - var(--tw-space-y-reverse)))}.space-y-xs>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:calc(var(--spacing-xs)*var(--tw-space-y-reverse));margin-top:calc(var(--spacing-xs)*(1 - var(--tw-space-y-reverse)))}.divide-y>:not([hidden])~:not([hidden]){--tw-divide-y-reverse:0;border-bottom-width:0;border-bottom-width:calc(1px*var(--tw-divide-y-reverse));border-top-width:1px;border-top-width:calc(1px*(1 - var(--tw-divide-y-reverse)))}.divide-color-default>:not([hidden])~:not([hidden]){--tw-divide-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-divide-opacity))}.self-center{align-self:center}.overflow-auto{overflow:auto}.\!overflow-hidden{overflow:hidden!important}.overflow-hidden{overflow:hidden}.\!overflow-visible{overflow:visible!important}.overflow-scroll{overflow:scroll}.overflow-x-auto{overflow-x:auto}.overflow-y-auto{overflow-y:auto}.overflow-y-hidden{overflow-y:hidden}.overflow-y-scroll{overflow-y:scroll}.overscroll-none{overscroll-behavior:none}.truncate{overflow:hidden;white-space:nowrap}.text-ellipsis,.truncate{text-overflow:ellipsis}.whitespace-nowrap{white-space:nowrap}.whitespace-pre{white-space:pre}.whitespace-pre-line{white-space:pre-line}.\!break-words{overflow-wrap:break-word!important}.break-words{overflow-wrap:break-word}.\!break-all{word-break:break-all!important}.break-all{word-break:break-all}.rounded{border-radius:.25rem}.rounded-2xl{border-radius:1rem}.rounded-3xl{border-radius:1.5rem}.rounded-\[0\.15em\]{border-radius:.15em}.rounded-\[100\%\]{border-radius:100%}.rounded-\[4px\]{border-radius:4px}.rounded-\[50\%\]{border-radius:50%}.rounded-full{border-radius:9999px}.rounded-lg{border-radius:.5rem}.rounded-md{border-radius:.375rem}.rounded-none{border-radius:0}.rounded-sm{border-radius:.125rem}.rounded-xl{border-radius:.75rem}.border{border-width:1px}.border-2{border-width:2px}.border-\[\.0625rem\]{border-width:.0625rem}.border-\[0\.15em\]{border-width:.15em}.border-x-0{border-left-width:0;border-right-width:0}.border-b{border-bottom-width:1px}.border-b-2{border-bottom-width:2px}.border-l{border-left-width:1px}.border-l-2{border-left-width:2px}.border-l-\[0\.0625rem\]{border-left-width:.0625rem}.border-l-\[0\.125rem\]{border-left-width:.125rem}.border-l-\[3px\]{border-left-width:3px}.border-r{border-right-width:1px}.border-t{border-top-width:1px}.border-t-0{border-top-width:0}.border-t-2{border-top-width:2px}.border-t-\[\.0625rem\]{border-top-width:.0625rem}.border-solid{border-style:solid}.border-dashed{border-style:dashed}.border-none{border-style:none}.\!border-color-bold{--tw-border-opacity:1!important;border-color:rgba(var(--color-border-bold),var(--tw-border-opacity))!important}.\!border-color-brand{--tw-border-opacity:1!important;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity))!important}.border-\[\#000\]{--tw-border-opacity:1;border-color:#000;border-color:rgb(0 0 0/var(--tw-border-opacity))}.border-\[\#DCDFE4\]{--tw-border-opacity:1;border-color:#dcdfe4;border-color:rgb(220 223 228/var(--tw-border-opacity))}.border-\[\#F8F9FD\]{--tw-border-opacity:1;border-color:#f8f9fd;border-color:rgb(248 249 253/var(--tw-border-opacity))}.border-\[\#FACC15\]{--tw-border-opacity:1;border-color:#facc15;border-color:rgb(250 204 21/var(--tw-border-opacity))}.border-\[\#FEF9C3\]{--tw-border-opacity:1;border-color:#fef9c3;border-color:rgb(254 249 195/var(--tw-border-opacity))}.border-\[\#b3b9c4\]{--tw-border-opacity:1;border-color:#b3b9c4;border-color:rgb(179 185 196/var(--tw-border-opacity))}.border-\[\#dcdfe6\]{--tw-border-opacity:1;border-color:#dcdfe6;border-color:rgb(220 223 230/var(--tw-border-opacity))}.border-\[\#f8f9fd\]{--tw-border-opacity:1;border-color:#f8f9fd;border-color:rgb(248 249 253/var(--tw-border-opacity))}.border-\[white\]{--tw-border-opacity:1;border-color:#fff;border-color:rgb(255 255 255/var(--tw-border-opacity))}.border-color-bold{--tw-border-opacity:1;border-color:rgba(var(--color-border-bold),var(--tw-border-opacity))}.border-color-brand{--tw-border-opacity:1;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity))}.border-color-default{--tw-border-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.border-color-error{--tw-border-opacity:1;border-color:rgba(var(--color-border-error),var(--tw-border-opacity))}.border-color-info{--tw-border-opacity:1;border-color:rgba(var(--color-border-info),var(--tw-border-opacity))}.border-color-inherit{border-color:inherit}.border-color-success{--tw-border-opacity:1;border-color:rgba(var(--color-border-success),var(--tw-border-opacity))}.border-color-transparent{border-color:#0000}.border-color-warning{--tw-border-opacity:1;border-color:rgba(var(--color-border-warning),var(--tw-border-opacity))}.border-t-color-default{--tw-border-opacity:1;border-top-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.\!bg-black{--tw-bg-opacity:1!important;background-color:rgba(var(--color-black),1)!important;background-color:rgba(var(--color-black),var(--tw-bg-opacity))!important}.\!bg-brand-bold{--tw-bg-opacity:1!important;background-color:rgba(var(--color-brand-bold),1)!important;background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))!important}.\!bg-brand-default{--tw-bg-opacity:1!important;background-color:rgba(var(--color-brand-default),1)!important;background-color:rgba(var(--color-brand-default),var(--tw-bg-opacity))!important}.\!bg-brand-subtler{--tw-bg-opacity:1!important;background-color:rgba(var(--color-brand-subtler),1)!important;background-color:rgba(var(--color-brand-subtler),var(--tw-bg-opacity))!important}.\!bg-brand-sunken{--tw-bg-opacity:1!important;background-color:rgba(var(--color-brand-sunken),1)!important;background-color:rgba(var(--color-brand-sunken),var(--tw-bg-opacity))!important}.\!bg-success-subtlest{--tw-bg-opacity:1!important;background-color:rgba(var(--color-bg-success-subtlest),1)!important;background-color:rgba(var(--color-bg-success-subtlest),var(--tw-bg-opacity))!important}.\!bg-surface-disabled{--tw-bg-opacity:1!important;background-color:rgba(var(--color-surface-disabled),1)!important;background-color:rgba(var(--color-surface-disabled),var(--tw-bg-opacity))!important}.\!bg-surface-subtle{--tw-bg-opacity:1!important;background-color:rgba(var(--color-surface-subtle),1)!important;background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))!important}.\!bg-warning-bold{--tw-bg-opacity:1!important;background-color:rgba(var(--color-bg-warning-bold),1)!important;background-color:rgba(var(--color-bg-warning-bold),var(--tw-bg-opacity))!important}.bg-\[\#000000\],.bg-\[\#000\]{--tw-bg-opacity:1;background-color:#000;background-color:rgb(0 0 0/var(--tw-bg-opacity))}.bg-\[\#2867B2\]{--tw-bg-opacity:1;background-color:#2867b2;background-color:rgb(40 103 178/var(--tw-bg-opacity))}.bg-\[\#409eff\]{--tw-bg-opacity:1;background-color:#409eff;background-color:rgb(64 158 255/var(--tw-bg-opacity))}.bg-\[\#66b1ff\]{--tw-bg-opacity:1;background-color:#66b1ff;background-color:rgb(102 177 255/var(--tw-bg-opacity))}.bg-\[\#EAB308\]{--tw-bg-opacity:1;background-color:#eab308;background-color:rgb(234 179 8/var(--tw-bg-opacity))}.bg-\[\#F8F9FD\]{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgb(248 249 253/var(--tw-bg-opacity))}.bg-\[\#b3b9c4\]{--tw-bg-opacity:1;background-color:#b3b9c4;background-color:rgb(179 185 196/var(--tw-bg-opacity))}.bg-\[\#eaeaee\]{--tw-bg-opacity:1;background-color:#eaeaee;background-color:rgb(234 234 238/var(--tw-bg-opacity))}.bg-\[\#facc15\]{--tw-bg-opacity:1;background-color:#facc15;background-color:rgb(250 204 21/var(--tw-bg-opacity))}.bg-\[\#fff\]{--tw-bg-opacity:1;background-color:#fff;background-color:rgb(255 255 255/var(--tw-bg-opacity))}.bg-black{--tw-bg-opacity:1;background-color:rgba(var(--color-black),1);background-color:rgba(var(--color-black),var(--tw-bg-opacity))}.bg-black\/50{background-color:rgba(var(--color-black),.5)}.bg-black\/60{background-color:rgba(var(--color-black),.6)}.bg-black\/\[0\.12\]{background-color:rgba(var(--color-black),.12)}.bg-brand-bold{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.bg-brand-boldest{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-boldest),1);background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.bg-brand-default{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-default),1);background-color:rgba(var(--color-brand-default),var(--tw-bg-opacity))}.bg-brand-subtler{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-subtler),1);background-color:rgba(var(--color-brand-subtler),var(--tw-bg-opacity))}.bg-brand-subtlest{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-subtlest),1);background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.bg-brand-sunken{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-sunken),1);background-color:rgba(var(--color-brand-sunken),var(--tw-bg-opacity))}.bg-content-bolder{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-bolder),1);background-color:rgba(var(--color-bg-content-bolder),var(--tw-bg-opacity))}.bg-content-default{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-default),1);background-color:rgba(var(--color-bg-content-default),var(--tw-bg-opacity))}.bg-content-inverse-subtler{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-inverse-subtler),1);background-color:rgba(var(--color-bg-content-inverse-subtler),var(--tw-bg-opacity))}.bg-content-subtle{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtle),1);background-color:rgba(var(--color-bg-content-subtle),var(--tw-bg-opacity))}.bg-content-subtler{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtler),1);background-color:rgba(var(--color-bg-content-subtler),var(--tw-bg-opacity))}.bg-content-subtlest{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtlest),1);background-color:rgba(var(--color-bg-content-subtlest),var(--tw-bg-opacity))}.bg-content-sunken{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-sunken),1);background-color:rgba(var(--color-bg-content-sunken),var(--tw-bg-opacity))}.bg-error-bold{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-error-bold),1);background-color:rgba(var(--color-bg-error-bold),var(--tw-bg-opacity))}.bg-error-subtlest{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-error-subtlest),1);background-color:rgba(var(--color-bg-error-subtlest),var(--tw-bg-opacity))}.bg-error-sunken{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-error-sunken),1);background-color:rgba(var(--color-bg-error-sunken),var(--tw-bg-opacity))}.bg-info-bold{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-info-bold),1);background-color:rgba(var(--color-bg-info-bold),var(--tw-bg-opacity))}.bg-info-subtlest{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-info-subtlest),1);background-color:rgba(var(--color-bg-info-subtlest),var(--tw-bg-opacity))}.bg-info-sunken{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-info-sunken),1);background-color:rgba(var(--color-bg-info-sunken),var(--tw-bg-opacity))}.bg-inherit{background-color:inherit}.bg-success-bold{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-success-bold),1);background-color:rgba(var(--color-bg-success-bold),var(--tw-bg-opacity))}.bg-success-subtlest{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-success-subtlest),1);background-color:rgba(var(--color-bg-success-subtlest),var(--tw-bg-opacity))}.bg-success-sunken{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-success-sunken),1);background-color:rgba(var(--color-bg-success-sunken),var(--tw-bg-opacity))}.bg-surface-default{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.bg-surface-disabled{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-disabled),1);background-color:rgba(var(--color-surface-disabled),var(--tw-bg-opacity))}.bg-surface-inverse{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-inverse),1);background-color:rgba(var(--color-surface-inverse),var(--tw-bg-opacity))}.bg-surface-selected{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-selected),1);background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))}.bg-surface-subtle{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.bg-transparent{background-color:initial}.bg-warning-bold{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-warning-bold),1);background-color:rgba(var(--color-bg-warning-bold),var(--tw-bg-opacity))}.bg-warning-subtlest{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-warning-subtlest),1);background-color:rgba(var(--color-bg-warning-subtlest),var(--tw-bg-opacity))}.bg-warning-sunken{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-warning-sunken),1);background-color:rgba(var(--color-bg-warning-sunken),var(--tw-bg-opacity))}.bg-white{--tw-bg-opacity:1;background-color:rgba(var(--color-white),1);background-color:rgba(var(--color-white),var(--tw-bg-opacity))}.bg-opacity-25{--tw-bg-opacity:0.25}.bg-opacity-75{--tw-bg-opacity:0.75}.bg-\[url$\'\/img\/homepage\.png\'$\]{background-image:url(/img/homepage.png)}.bg-gradient-to-r{background-image:linear-gradient(to right,var(--tw-gradient-stops))}.bg-none{background-image:none}.from-black\/70{--tw-gradient-from:rgba(var(--color-black),0.7) var(--tw-gradient-from-position);--tw-gradient-to:rgba(var(--color-black),0) var(--tw-gradient-to-position);--tw-gradient-stops:var(--tw-gradient-from),var(--tw-gradient-to)}.from-transparent{--tw-gradient-from:#0000 var(--tw-gradient-from-position);--tw-gradient-to:#0000 var(--tw-gradient-to-position);--tw-gradient-stops:var(--tw-gradient-from),var(--tw-gradient-to)}.to-black\/5{--tw-gradient-to:rgba(var(--color-black),0.05) var(--tw-gradient-to-position)}.to-white{--tw-gradient-to:rgba(var(--color-white),1) var(--tw-gradient-to-position)}.bg-cover{background-size:cover}.bg-fixed{background-attachment:fixed}.bg-center{background-position:50%}.bg-no-repeat{background-repeat:no-repeat}.fill-brand-bold{fill:rgba(var(--color-brand-bold),1)}.fill-brand-sunken{fill:rgba(var(--color-brand-sunken),1)}.object-cover{object-fit:cover}.\!p-0{padding:0!important}.\!p-sm{padding:var(--spacing-sm)!important}.\!p-xs{padding:var(--spacing-xs)!important}.p-0{padding:0}.p-0\.5{padding:.125rem}.p-4{padding:1rem}.p-5{padding:1.25rem}.p-8{padding:2rem}.p-\[\.75rem\]{padding:.75rem}.p-lg{padding:var(--spacing-lg)}.p-md{padding:var(--spacing-md)}.p-px{padding:1px}.p-sm{padding:var(--spacing-sm)}.p-xl{padding:var(--spacing-xl)}.\!px-0{padding-left:0!important;padding-right:0!important}.\!px-sm{padding-left:var(--spacing-sm)!important;padding-right:var(--spacing-sm)!important}.px-0{padding-left:0;padding-right:0}.px-10{padding-left:2.5rem;padding-right:2.5rem}.px-2{padding-left:.5rem;padding-right:.5rem}.px-4{padding-left:1rem;padding-right:1rem}.px-5{padding-left:1.25rem;padding-right:1.25rem}.px-8{padding-left:2rem;padding-right:2rem}.px-\[\.625rem\]{padding-left:.625rem;padding-right:.625rem}.px-\[\.9375rem\]{padding-left:.9375rem;padding-right:.9375rem}.px-\[0\.2rem\]{padding-left:.2rem;padding-right:.2rem}.px-\[0\.625rem\]{padding-left:.625rem;padding-right:.625rem}.px-lg{padding-left:var(--spacing-lg);padding-right:var(--spacing-lg)}.px-md{padding-left:var(--spacing-md);padding-right:var(--spacing-md)}.px-sm{padding-left:var(--spacing-sm);padding-right:var(--spacing-sm)}.px-xl{padding-left:var(--spacing-xl);padding-right:var(--spacing-xl)}.px-xs{padding-left:var(--spacing-xs);padding-right:var(--spacing-xs)}.py-0{padding-bottom:0;padding-top:0}.py-0\.5{padding-bottom:.125rem;padding-top:.125rem}.py-10{padding-bottom:2.5rem;padding-top:2.5rem}.py-2{padding-bottom:.5rem;padding-top:.5rem}.py-2xl{padding-bottom:var(--spacing-2xl);padding-top:var(--spacing-2xl)}.py-3{padding-bottom:.75rem;padding-top:.75rem}.py-3xl{padding-bottom:var(--spacing-3xl);padding-top:var(--spacing-3xl)}.py-4{padding-bottom:1rem;padding-top:1rem}.py-5xl{padding-bottom:var(--spacing-5xl);padding-top:var(--spacing-5xl)}.py-6{padding-bottom:1.5rem;padding-top:1.5rem}.py-7xl{padding-bottom:var(--spacing-7xl);padding-top:var(--spacing-7xl)}.py-\[\.3125rem\]{padding-bottom:.3125rem;padding-top:.3125rem}.py-\[0\.625rem\],.py-\[\.625rem\]{padding-bottom:.625rem;padding-top:.625rem}.py-\[1\.5rem\]{padding-bottom:1.5rem;padding-top:1.5rem}.py-lg{padding-bottom:var(--spacing-lg);padding-top:var(--spacing-lg)}.py-md{padding-bottom:var(--spacing-md);padding-top:var(--spacing-md)}.py-sm{padding-bottom:var(--spacing-sm);padding-top:var(--spacing-sm)}.py-xl{padding-bottom:var(--spacing-xl);padding-top:var(--spacing-xl)}.py-xs{padding-bottom:var(--spacing-xs);padding-top:var(--spacing-xs)}.\!pl-0{padding-left:0!important}.\!pl-sm{padding-left:var(--spacing-sm)!important}.\!pr-sm{padding-right:var(--spacing-sm)!important}.pb-0{padding-bottom:0}.pb-2xl{padding-bottom:var(--spacing-2xl)}.pb-3{padding-bottom:.75rem}.pb-6{padding-bottom:1.5rem}.pb-7xl{padding-bottom:var(--spacing-7xl)}.pb-\[\.5rem\]{padding-bottom:.5rem}.pb-\[1\.875rem\]{padding-bottom:1.875rem}.pb-lg{padding-bottom:var(--spacing-lg)}.pb-md{padding-bottom:var(--spacing-md)}.pb-sm{padding-bottom:var(--spacing-sm)}.pb-xl{padding-bottom:var(--spacing-xl)}.pb-xs{padding-bottom:var(--spacing-xs)}.pl-0{padding-left:0}.pl-10{padding-left:2.5rem}.pl-2xl{padding-left:var(--spacing-2xl)}.pl-3{padding-left:.75rem}.pl-5{padding-left:1.25rem}.pl-8{padding-left:2rem}.pl-lg{padding-left:var(--spacing-lg)}.pl-md{padding-left:var(--spacing-md)}.pl-sm{padding-left:var(--spacing-sm)}.pl-xl{padding-left:var(--spacing-xl)}.pl-xs{padding-left:var(--spacing-xs)}.pr-0{padding-right:0}.pr-2xl{padding-right:var(--spacing-2xl)}.pr-3{padding-right:.75rem}.pr-lg{padding-right:var(--spacing-lg)}.pr-md{padding-right:var(--spacing-md)}.pr-sm{padding-right:var(--spacing-sm)}.pr-xl{padding-right:var(--spacing-xl)}.pr-xs{padding-right:var(--spacing-xs)}.pt-12{padding-top:3rem}.pt-14{padding-top:3.5rem}.pt-2xl{padding-top:var(--spacing-2xl)}.pt-3xl{padding-top:var(--spacing-3xl)}.pt-5xl{padding-top:var(--spacing-5xl)}.pt-6{padding-top:1.5rem}.pt-7xl{padding-top:var(--spacing-7xl)}.pt-\[\.625rem\]{padding-top:.625rem}.pt-\[\.75rem\]{padding-top:.75rem}.pt-\[0\.125rem\]{padding-top:.125rem}.pt-\[1\.25rem\]{padding-top:1.25rem}.pt-\[1\.875rem\]{padding-top:1.875rem}.pt-\[1rem\]{padding-top:1rem}.pt-\[2rem\]{padding-top:2rem}.pt-\[5rem\]{padding-top:5rem}.pt-lg{padding-top:var(--spacing-lg)}.pt-md{padding-top:var(--spacing-md)}.pt-sm{padding-top:var(--spacing-sm)}.pt-xl{padding-top:var(--spacing-xl)}.pt-xs{padding-top:var(--spacing-xs)}.text-left{text-align:left}.text-center{text-align:center}.text-right{text-align:right}.\!align-middle{vertical-align:middle!important}.align-middle{vertical-align:middle}.\!align-text-bottom{vertical-align:text-bottom!important}.\!text-base{font-size:1rem!important;line-height:1.5rem!important}.\!text-lg{font-size:1.125rem!important;line-height:1.75rem!important}.\!text-xs{font-size:.75rem!important;line-height:1rem!important}.text-2xl{font-size:1.5rem;line-height:2rem}.text-3xl{font-size:1.875rem;line-height:2.25rem}.text-4xl{font-size:2.25rem;line-height:2.5rem}.text-5xl{font-size:3rem;line-height:1}.text-\[\.4rem\]{font-size:.4rem}.text-\[\.75rem\]{font-size:.75rem}.text-\[\.875rem\]{font-size:.875rem}.text-\[0\.4rem\]{font-size:.4rem}.text-\[0\.575rem\]{font-size:.575rem}.text-\[1\.875rem\]{font-size:1.875rem}.text-\[2\.5rem\]{font-size:2.5rem}.text-base{font-size:1rem;line-height:1.5rem}.text-lg{font-size:1.125rem;line-height:1.75rem}.text-sm{font-size:.875rem;line-height:1.25rem}.text-xl{font-size:1.25rem;line-height:1.75rem}.text-xs{font-size:.75rem;line-height:1rem}.font-bold{font-weight:700}.font-light{font-weight:300}.font-medium{font-weight:500}.font-normal{font-weight:400}.font-semibold{font-weight:600}.uppercase{text-transform:uppercase}.lowercase{text-transform:lowercase}.italic{font-style:italic}.\!leading-\[0\]{line-height:0!important}.leading-10{line-height:2.5rem}.leading-6{line-height:1.5rem}.leading-\[0\]{line-height:0}.leading-\[1\.125rem\]{line-height:1.125rem}.leading-\[1\.1\]{line-height:1.1}.leading-\[1\.875rem\]{line-height:1.875rem}.leading-\[140\%\]{line-height:140%}.leading-none{line-height:1}.leading-normal{line-height:1.5}.\!text-color-black{--tw-text-opacity:1!important;color:rgba(var(--color-black),1)!important;color:rgba(var(--color-black),var(--tw-text-opacity))!important}.\!text-color-brand-bold{--tw-text-opacity:1!important;color:rgba(var(--color-text-brand-bold),1)!important;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))!important}.\!text-color-default{--tw-text-opacity:1!important;color:rgba(var(--color-text-default),1)!important;color:rgba(var(--color-text-default),var(--tw-text-opacity))!important}.\!text-color-disabled{--tw-text-opacity:1!important;color:rgba(var(--color-text-disabled),1)!important;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))!important}.\!text-color-link-bold{--tw-text-opacity:1!important;color:rgba(var(--color-text-link-bold),1)!important;color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))!important}.\!text-color-subtle{--tw-text-opacity:1!important;color:rgba(var(--color-text-subtle),1)!important;color:rgba(var(--color-text-subtle),var(--tw-text-opacity))!important}.\!text-color-white{--tw-text-opacity:1!important;color:rgba(var(--color-white),1)!important;color:rgba(var(--color-white),var(--tw-text-opacity))!important}.text-\[\#000\]{--tw-text-opacity:1;color:#000;color:rgb(0 0 0/var(--tw-text-opacity))}.text-\[\#0156CE\]{--tw-text-opacity:1;color:#0156ce;color:rgb(1 86 206/var(--tw-text-opacity))}.text-\[\#172B4D\]{--tw-text-opacity:1;color:#172b4d;color:rgb(23 43 77/var(--tw-text-opacity))}.text-\[\#626F86\]{--tw-text-opacity:1;color:#626f86;color:rgb(98 111 134/var(--tw-text-opacity))}.text-\[\#758195\]{--tw-text-opacity:1;color:#758195;color:rgb(117 129 149/var(--tw-text-opacity))}.text-\[\#EAB308\]{--tw-text-opacity:1;color:#eab308;color:rgb(234 179 8/var(--tw-text-opacity))}.text-\[\#F1F2F4\]{--tw-text-opacity:1;color:#f1f2f4;color:rgb(241 242 244/var(--tw-text-opacity))}.text-\[\#FACC15\]{--tw-text-opacity:1;color:#facc15;color:rgb(250 204 21/var(--tw-text-opacity))}.text-\[\#FFFFFF\]{--tw-text-opacity:1;color:#fff;color:rgb(255 255 255/var(--tw-text-opacity))}.text-\[\#b3b9c4\]{--tw-text-opacity:1;color:#b3b9c4;color:rgb(179 185 196/var(--tw-text-opacity))}.text-\[\#f00\]{--tw-text-opacity:1;color:red;color:rgb(255 0 0/var(--tw-text-opacity))}.text-\[\#fff\]{--tw-text-opacity:1;color:#fff;color:rgb(255 255 255/var(--tw-text-opacity))}.text-color-black{--tw-text-opacity:1;color:rgba(var(--color-black),1);color:rgba(var(--color-black),var(--tw-text-opacity))}.text-color-border-bold{--tw-text-opacity:1;color:rgba(var(--color-border-bold),1);color:rgba(var(--color-border-bold),var(--tw-text-opacity))}.text-color-brand-bold{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.text-color-brand-bolder{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bolder),1);color:rgba(var(--color-text-brand-bolder),var(--tw-text-opacity))}.text-color-current{color:currentColor}.text-color-default{--tw-text-opacity:1;color:rgba(var(--color-text-default),1);color:rgba(var(--color-text-default),var(--tw-text-opacity))}.text-color-disabled{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.text-color-error{--tw-text-opacity:1;color:rgba(var(--color-text-error),1);color:rgba(var(--color-text-error),var(--tw-text-opacity))}.text-color-info{--tw-text-opacity:1;color:rgba(var(--color-text-info),1);color:rgba(var(--color-text-info),var(--tw-text-opacity))}.text-color-inherit{color:inherit}.text-color-inverse{--tw-text-opacity:1;color:rgba(var(--color-white),1);color:rgba(var(--color-white),var(--tw-text-opacity))}.text-color-link-bold{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.text-color-link-bolder{--tw-text-opacity:1;color:rgba(var(--color-text-link-bolder),1);color:rgba(var(--color-text-link-bolder),var(--tw-text-opacity))}.text-color-link-subtle{--tw-text-opacity:1;color:rgba(var(--color-text-link-subtle),1);color:rgba(var(--color-text-link-subtle),var(--tw-text-opacity))}.text-color-on-brand{--tw-text-opacity:1;color:rgba(var(--color-text-on-brand),1);color:rgba(var(--color-text-on-brand),var(--tw-text-opacity))}.text-color-subtle{--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.text-color-subtlest{--tw-text-opacity:1;color:rgba(var(--color-text-subtlest),1);color:rgba(var(--color-text-subtlest),var(--tw-text-opacity))}.text-color-success{--tw-text-opacity:1;color:rgba(var(--color-text-success),1);color:rgba(var(--color-text-success),var(--tw-text-opacity))}.text-color-warning{--tw-text-opacity:1;color:rgba(var(--color-text-warning),1);color:rgba(var(--color-text-warning),var(--tw-text-opacity))}.text-color-white{--tw-text-opacity:1;color:rgba(var(--color-white),1);color:rgba(var(--color-white),var(--tw-text-opacity))}.underline{text-decoration-line:underline}.\!no-underline{text-decoration-line:none!important}.no-underline{text-decoration-line:none}.antialiased{-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}.placeholder-text-color-subtle::placeholder{--tw-placeholder-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-placeholder-opacity))}.opacity-0{opacity:0}.opacity-100{opacity:1}.opacity-25{opacity:.25}.opacity-40{opacity:.4}.shadow{--tw-shadow:0 1px 3px 0 #0000001a,0 1px 2px -1px #0000001a;--tw-shadow-colored:0 1px 3px 0 var(--tw-shadow-color),0 1px 2px -1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 1px 3px 0 #0000001a,0 1px 2px -1px #0000001a;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-\[4px_8px_10px_rgba$214\2c 217\2c 222\2c 0\.8$\]{--tw-shadow:4px 8px 10px #d6d9decc;--tw-shadow-colored:4px 8px 10px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,4px 8px 10px #d6d9decc;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-lg{--tw-shadow:0 10px 15px -3px #0000001a,0 4px 6px -4px #0000001a;--tw-shadow-colored:0 10px 15px -3px var(--tw-shadow-color),0 4px 6px -4px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 10px 15px -3px #0000001a,0 4px 6px -4px #0000001a;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-md{--tw-shadow:0 4px 6px -1px #0000001a,0 2px 4px -2px #0000001a;--tw-shadow-colored:0 4px 6px -1px var(--tw-shadow-color),0 2px 4px -2px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 4px 6px -1px #0000001a,0 2px 4px -2px #0000001a;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-slider{--tw-shadow:0.5px 0.5px 2px 1px #00000052;--tw-shadow-colored:0.5px 0.5px 2px 1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,.5px .5px 2px 1px #00000052;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-slider-active{--tw-shadow:0.5px 0.5px 2px 1px #0000006b;--tw-shadow-colored:0.5px 0.5px 2px 1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,.5px .5px 2px 1px #0000006b;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-sm{--tw-shadow:0 1px 2px 0 #0000000d;--tw-shadow-colored:0 1px 2px 0 var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 1px 2px 0 #0000000d;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-xl{--tw-shadow:0 20px 25px -5px #0000001a,0 8px 10px -6px #0000001a;--tw-shadow-colored:0 20px 25px -5px var(--tw-shadow-color),0 8px 10px -6px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 20px 25px -5px #0000001a,0 8px 10px -6px #0000001a;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.outline-none{outline:2px solid #0000;outline-offset:2px}.outline{outline-style:solid}.outline-2{outline-width:2px}.outline-offset-2{outline-offset:2px}.outline-\[\#EAB308\]{outline-color:#eab308}.outline-color-bold{outline-color:rgba(var(--color-border-bold),1)}.outline-color-brand{outline-color:rgba(var(--color-border-brand),1)}.ring-0{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.blur{--tw-blur:blur(8px);filter:blur(8px) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.grayscale{--tw-grayscale:grayscale(100%);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) grayscale(100%) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.filter,.grayscale{filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.transition{transition-duration:.15s;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke,opacity,box-shadow,transform,filter,-webkit-backdrop-filter;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke,opacity,box-shadow,transform,filter,backdrop-filter;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke,opacity,box-shadow,transform,filter,backdrop-filter,-webkit-backdrop-filter;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-all{transition-duration:.15s;transition-property:all;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-colors{transition-duration:.15s;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-height{transition-duration:.15s;transition-property:height;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-opacity{transition-duration:.15s;transition-property:opacity;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-transform{transition-duration:.15s;transition-property:transform;transition-timing-function:cubic-bezier(.4,0,.2,1)}.duration-100{transition-duration:.1s}.duration-150{transition-duration:.15s}.duration-200{transition-duration:.2s}.duration-300{transition-duration:.3s}.duration-75{transition-duration:75ms}.duration-\[350ms\]{transition-duration:.35s}.ease-in{transition-timing-function:cubic-bezier(.4,0,1,1)}.ease-in-out{transition-timing-function:cubic-bezier(.4,0,.2,1)}.ease-out{transition-timing-function:cubic-bezier(0,0,.2,1)}.content-\[\'\'\]{--tw-content:"";content:"";content:var(--tw-content)}.cursor-grab{cursor:grab}.cursor-grabbing{cursor:grabbing}.touch-none{touch-action:none}.tap-highlight-transparent{-webkit-tap-highlight-color:rgba(0,0,0,0)}.touch-callout-none{-webkit-touch-callout:none}.transform-origin-0{transform-origin:0 0}.transform-style-flat{transform-style:flat}.cursor-ew-resize{cursor:ew-resize}.arrow-left:before{border:5px solid #0000;border-right-color:inherit;left:-10px}.arrow-left:before,.arrow-right:before{content:"";height:0;position:absolute;top:50%;transform:translateY(-50%);width:0}.arrow-right:before{border:5px solid #0000;border-left-color:inherit;right:-10px}.text-body{font-size:.875rem;line-height:1.25rem}@media (min-width:768px){.text-body{font-size:1rem;line-height:1.5rem}}.\[appearance\:textfield\]{appearance:textfield}.before\:absolute:before{content:var(--tw-content);position:absolute}.before\:-inset-2:before{content:var(--tw-content);inset:-.5rem}.after\:absolute:after{content:var(--tw-content);position:absolute}.after\:hidden:after{content:var(--tw-content);display:none}.after\:h-1\/2:after{content:var(--tw-content);height:50%}.after\:w-1\/2:after{content:var(--tw-content);width:50%}.after\:rounded-full:after{border-radius:9999px;content:var(--tw-content)}.after\:bg-brand-bold:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.after\:bg-content-default:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-default),1);background-color:rgba(var(--color-bg-content-default),var(--tw-bg-opacity))}.first\:pt-0:first-child{padding-top:0}.focus-within\:outline-none:focus-within{outline:2px solid #0000;outline-offset:2px}.focus-within\:outline:focus-within{outline-style:solid}.hover\:rounded-2xl:hover{border-radius:1rem}.hover\:border-2:hover{border-width:2px}.hover\:border-\[\#0156CE\]:hover{--tw-border-opacity:1;border-color:#0156ce;border-color:rgb(1 86 206/var(--tw-border-opacity))}.hover\:border-\[\#F8F9FD\]:hover{--tw-border-opacity:1;border-color:#f8f9fd;border-color:rgb(248 249 253/var(--tw-border-opacity))}.hover\:border-color-brand:hover{--tw-border-opacity:1;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity))}.hover\:\!bg-surface-selected:hover{--tw-bg-opacity:1!important;background-color:rgba(var(--color-surface-selected),1)!important;background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))!important}.hover\:\!bg-transparent:hover{background-color:initial!important}.hover\:bg-brand-bolder:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bolder),1);background-color:rgba(var(--color-brand-bolder),var(--tw-bg-opacity))}.hover\:bg-brand-subtlest:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-subtlest),1);background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.hover\:bg-brand-sunken:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-sunken),1);background-color:rgba(var(--color-brand-sunken),var(--tw-bg-opacity))}.hover\:bg-content-bold:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-bold),1);background-color:rgba(var(--color-bg-content-bold),var(--tw-bg-opacity))}.hover\:bg-content-sunken:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-sunken),1);background-color:rgba(var(--color-bg-content-sunken),var(--tw-bg-opacity))}.hover\:bg-surface-default:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.hover\:bg-surface-selected:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-selected),1);background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))}.hover\:pl-sm:hover{padding-left:var(--spacing-sm)}.hover\:font-semibold:hover{font-weight:600}.hover\:\!text-color-black:hover{--tw-text-opacity:1!important;color:rgba(var(--color-black),1)!important;color:rgba(var(--color-black),var(--tw-text-opacity))!important}.hover\:text-color-black:hover{--tw-text-opacity:1;color:rgba(var(--color-black),1);color:rgba(var(--color-black),var(--tw-text-opacity))}.hover\:text-color-brand-bold:hover{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.hover\:text-color-link-bold:hover{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.hover\:text-color-link-bolder:hover{--tw-text-opacity:1;color:rgba(var(--color-text-link-bolder),1);color:rgba(var(--color-text-link-bolder),var(--tw-text-opacity))}.hover\:text-color-subtle:hover{--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.hover\:underline:hover{text-decoration-line:underline}.hover\:grayscale-0:hover{--tw-grayscale:grayscale(0);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) grayscale(0) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.focus\:bg-brand-strong:focus{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-strong),1);background-color:rgba(var(--color-brand-strong),var(--tw-bg-opacity))}.focus\:outline-none:focus{outline:2px solid #0000;outline-offset:2px}.focus\:outline-color-brand:focus{outline-color:rgba(var(--color-border-brand),1)}.focus\:ring-2:focus{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.focus\:ring-text-color-border-selected:focus{--tw-ring-opacity:1;--tw-ring-color:rgba(var(--color-border-selected),var(--tw-ring-opacity))}.focus-visible\:bg-brand-bold:focus-visible{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.focus-visible\:bg-brand-boldest:focus-visible{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-boldest),1);background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.focus-visible\:bg-error-bold:focus-visible{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-error-bold),1);background-color:rgba(var(--color-bg-error-bold),var(--tw-bg-opacity))}.focus-visible\:bg-surface-default:focus-visible{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.focus-visible\:bg-surface-selected:focus-visible{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-selected),1);background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))}.focus-visible\:outline-none:focus-visible{outline:2px solid #0000;outline-offset:2px}.focus-visible\:outline:focus-visible{outline-style:solid}.focus-visible\:outline-2:focus-visible{outline-width:2px}.focus-visible\:outline-color-selected:focus-visible{outline-color:rgba(var(--color-border-selected),1)}.focus-visible\:ring-2:focus-visible{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.focus-visible\:ring-offset-2:focus-visible{--tw-ring-offset-width:2px}.focus-visible\:ring-offset-brand-bold:focus-visible{--tw-ring-offset-color:rgba(var(--color-brand-bold),1)}.focus-visible\:ring-offset-white:focus-visible{--tw-ring-offset-color:rgba(var(--color-white),1)}.active\:\!bg-brand-subtlest:active{--tw-bg-opacity:1!important;background-color:rgba(var(--color-brand-subtlest),1)!important;background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))!important}.active\:\!bg-inherit:active{background-color:inherit!important}.active\:\!bg-transparent:active{background-color:initial!important}.active\:bg-brand-boldest:active{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-boldest),1);background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.active\:bg-brand-strong:active{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-strong),1);background-color:rgba(var(--color-brand-strong),var(--tw-bg-opacity))}.active\:bg-brand-subtler:active{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-subtler),1);background-color:rgba(var(--color-brand-subtler),var(--tw-bg-opacity))}.active\:bg-brand-subtlest:active{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-subtlest),1);background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.active\:bg-content-bolder:active{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-bolder),1);background-color:rgba(var(--color-bg-content-bolder),var(--tw-bg-opacity))}.active\:bg-content-subtlest:active{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtlest),1);background-color:rgba(var(--color-bg-content-subtlest),var(--tw-bg-opacity))}.active\:text-color-brand-boldest:active{--tw-text-opacity:1;color:rgba(var(--color-text-brand-boldest),1);color:rgba(var(--color-text-brand-boldest),var(--tw-text-opacity))}.disabled\:border-color-default:disabled{--tw-border-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.disabled\:bg-surface-subtle:disabled{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.disabled\:text-color-disabled:disabled{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.group:hover .group-hover\:after\:bg-brand-bolder:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bolder),1);background-color:rgba(var(--color-brand-bolder),var(--tw-bg-opacity))}.group:active .group-active\:after\:bg-brand-boldest:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:rgba(var(--color-brand-boldest),1);background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.aria-disabled\:pointer-events-none[aria-disabled=true]{pointer-events:none}.aria-disabled\:cursor-default[aria-disabled=true]{cursor:default}.aria-disabled\:text-color-disabled[aria-disabled=true]{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.ui-open\:text-color-brand-bold[data-headlessui-state~=open]{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}:where([data-headlessui-state~=open]) .ui-open\:text-color-brand-bold{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.ui-disabled\:pointer-events-none[data-headlessui-state~=disabled]{pointer-events:none}.ui-disabled\:cursor-default[data-headlessui-state~=disabled]{cursor:default}.ui-disabled\:text-color-disabled[data-headlessui-state~=disabled]{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}:where([data-headlessui-state~=disabled]) .ui-disabled\:pointer-events-none{pointer-events:none}:where([data-headlessui-state~=disabled]) .ui-disabled\:cursor-default{cursor:default}:where([data-headlessui-state~=disabled]) .ui-disabled\:text-color-disabled{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}:where([data-headlessui-focus-visible]) .ui-focus-visible\:outline-color-brand:focus{outline-color:rgba(var(--color-border-brand),1)}:where([data-headlessui-focus-visible]) .ui-focus-visible\:ring-2:focus{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}:where([data-headlessui-focus-visible]) .ui-focus-visible\:ring-brand-bold:focus{--tw-ring-opacity:1;--tw-ring-color:rgba(var(--color-brand-bold),var(--tw-ring-opacity))}:where([data-headlessui-focus-visible]) .ui-focus-visible\:ring-opacity-75:focus{--tw-ring-opacity:0.75}.slider-horizontal .h\:-right-2{right:-.5rem}.slider-horizontal .h\:-top-1{top:-.25rem}.slider-horizontal .h\:-top-1\.5{top:-.375rem}.slider-horizontal .h\:left-1\/2{left:50%}.slider-horizontal .h\:h-0{height:0}.slider-horizontal .h\:h-4{height:1rem}.slider-horizontal .h\:w-4{width:1rem}.slider-horizontal .h\:-translate-x-1\/2{--tw-translate-x:-50%;transform:translate(-50%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-horizontal .h\:arrow-bottom:before{border:5px solid #0000;border-top-color:inherit;bottom:-10px}.slider-horizontal .h\:arrow-bottom:before,.slider-horizontal .h\:arrow-top:before{content:"";height:0;left:50%;position:absolute;transform:translate(-50%);width:0}.slider-horizontal .h\:arrow-top:before{border:5px solid #0000;border-bottom-color:inherit;top:-10px}.slider-vertical .v\:-right-1{right:-.25rem}.slider-vertical .v\:-right-1\.25{right:-.3125rem}.slider-vertical .v\:-top-2{top:-.5rem}.slider-vertical .v\:-top-full{top:-100%}.slider-vertical .v\:top-1\/2{top:50%}.slider-vertical .v\:h-4{height:1rem}.slider-vertical .v\:w-0{width:0}.slider-vertical .v\:w-4{width:1rem}.slider-vertical .v\:-translate-y-1\/2{--tw-translate-y:-50%;transform:translate(var(--tw-translate-x),-50%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-vertical .v\:cursor-ns-resize{cursor:ns-resize}.slider-vertical .v\:arrow-left:before{border:5px solid #0000;border-right-color:inherit;left:-10px}.slider-vertical .v\:arrow-left:before,.slider-vertical .v\:arrow-right:before{content:"";height:0;position:absolute;top:50%;transform:translateY(-50%);width:0}.slider-vertical .v\:arrow-right:before{border:5px solid #0000;border-left-color:inherit;right:-10px}.slider-horizontal .slider-origin>.merge-h\:bottom-3{bottom:.75rem}.slider-horizontal .slider-origin>.merge-h\:bottom-3\.5{bottom:.875rem}.slider-horizontal .slider-origin>.merge-h\:left-auto{left:auto}.slider-horizontal .slider-origin>.merge-h\:top-5{top:1.25rem}.slider-horizontal .slider-origin>.merge-h\:translate-x-1\/2{--tw-translate-x:50%;transform:translate(50%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-vertical .slider-origin>.merge-v\:left-7{left:1.75rem}.slider-vertical .slider-origin>.merge-v\:right-1{right:.25rem}.slider-vertical .slider-origin>.merge-v\:top-auto{top:auto}.slider-vertical .slider-origin>.merge-v\:-translate-x-4{--tw-translate-x:-1rem;transform:translate(-1rem,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-horizontal.slider-txt-rtl .txt-rtl-h\:-left-2{left:-.5rem}.slider-horizontal.slider-txt-rtl .txt-rtl-h\:left-0{left:0}.slider-horizontal.slider-txt-rtl .txt-rtl-h\:right-auto{right:auto}.slider-tap .tap\:transition-transform{transition-duration:.15s;transition-property:transform;transition-timing-function:cubic-bezier(.4,0,.2,1)}.slider-tap .tap\:duration-300{transition-duration:.3s}.slider-tooltip-focus:not(.slider-focused) .tt-focus\:hidden{display:none!important}.slider-tooltip-focus.slider-focused:not(.slider-tooltip-hidden) .tt-focused\:block{display:block!important}.slider-tooltip-drag:not(.slider-state-drag) .tt-drag\:hidden{display:none!important}.slider-tooltip-drag.slider-state-drag .tt-dragging\:block\:not$\.slider-tooltip-hidden${display:block!important}@media not all and (min-width:1280px){.max-xl\:w-full{width:100%}}@media not all and (min-width:1024px){.max-lg\:items-center{align-items:center}.max-lg\:gap-x-6{column-gap:1.5rem}.max-lg\:pt-lg{padding-top:var(--spacing-lg)}}@media (min-width:576px){.sm\:sticky{position:sticky}.sm\:top-20{top:5rem}.sm\:w-20{width:5rem}.sm\:w-2xl{width:var(--spacing-2xl)}.sm\:w-\[100\%\]{width:100%}.sm\:w-\[50\%\]{width:50%}.sm\:\!max-w-\[20\%\]{max-width:20%!important}.sm\:max-w-\[33\%\]{max-width:33%}.sm\:grid-cols-2{grid-template-columns:repeat(2,minmax(0,1fr))}.sm\:border-0{border-width:0}.sm\:border-t{border-top-width:1px}.sm\:border-\[\#000\]{--tw-border-opacity:1;border-color:#000;border-color:rgb(0 0 0/var(--tw-border-opacity))}.sm\:pr-md{padding-right:var(--spacing-md)}.sm\:pt-0{padding-top:0}.sm\:pt-\[\.625rem\]{padding-top:.625rem}}@media (min-width:768px){.md\:h-9{height:2.25rem}.md\:w-9{width:2.25rem}.md\:w-\[100\%\]{width:100%}.md\:w-\[50\%\]{width:50%}.md\:flex-row{flex-direction:row}.md\:flex-row-reverse{flex-direction:row-reverse}}@media (min-width:1024px){.lg\:absolute{position:absolute}.lg\:sticky{position:sticky}.lg\:\!bottom-\[50vh\]{bottom:50vh!important}.lg\:bottom-xl{bottom:var(--spacing-xl)}.lg\:left-xl{left:var(--spacing-xl)}.lg\:top-7xl{top:var(--spacing-7xl)}.lg\:top-\[10\%\]{top:10%}.lg\:top-\[20\%\]{top:20%}.lg\:top-\[30\%\]{top:30%}.lg\:top-\[4\.5rem\]{top:4.5rem}.lg\:top-\[40\%\]{top:40%}.lg\:top-\[50\%\]{top:50%}.lg\:top-\[60\%\]{top:60%}.lg\:top-\[70\%\]{top:70%}.lg\:order-first{order:-9999}.lg\:m-0{margin:0}.lg\:m-lg{margin:var(--spacing-lg)}.lg\:mx-auto{margin-left:auto;margin-right:auto}.lg\:my-0{margin-bottom:0;margin-top:0}.lg\:my-12{margin-bottom:3rem;margin-top:3rem}.lg\:my-7xl{margin-bottom:var(--spacing-7xl);margin-top:var(--spacing-7xl)}.lg\:my-\[18\.75rem\]{margin-bottom:18.75rem;margin-top:18.75rem}.lg\:-mt-4xl{margin-top:calc(var(--spacing-4xl)*-1)}.lg\:mb-0{margin-bottom:0}.lg\:mb-10xl{margin-bottom:var(--spacing-10xl)}.lg\:mb-lg{margin-bottom:var(--spacing-lg)}.lg\:ml-3xl{margin-left:var(--spacing-3xl)}.lg\:ml-lg{margin-left:var(--spacing-lg)}.lg\:ml-sm{margin-left:var(--spacing-sm)}.lg\:mr-8xl{margin-right:var(--spacing-8xl)}.lg\:mr-\[4\.6875rem\]{margin-right:4.6875rem}.lg\:mr-lg{margin-right:var(--spacing-lg)}.lg\:mr-xl{margin-right:var(--spacing-xl)}.lg\:mt-0{margin-top:0}.lg\:mt-\[-3rem\]{margin-top:-3rem}.lg\:mt-lg{margin-top:var(--spacing-lg)}.lg\:mt-md{margin-top:var(--spacing-md)}.lg\:\!block{display:block!important}.lg\:block{display:block}.lg\:flex{display:flex}.lg\:\!inline-flex{display:inline-flex!important}.lg\:grid{display:grid}.lg\:\!hidden{display:none!important}.lg\:hidden{display:none}.lg\:aspect-\[1\/1\.414\]{aspect-ratio:1/1.414}.lg\:aspect-square{aspect-ratio:1/1}.lg\:h-12{height:3rem}.lg\:h-\[296px\]{height:296px}.lg\:h-\[7\.5rem\]{height:7.5rem}.lg\:max-h-\[100\%\]{max-height:100%}.lg\:max-h-\[30\%\]{max-height:30%}.lg\:max-h-\[40\%\]{max-height:40%}.lg\:max-h-\[50\%\]{max-height:50%}.lg\:max-h-\[60\%\]{max-height:60%}.lg\:max-h-\[70\%\]{max-height:70%}.lg\:max-h-\[80\%\]{max-height:80%}.lg\:max-h-\[90\%\]{max-height:90%}.lg\:min-h-screen{min-height:100vh}.lg\:\!w-\[20\%\]{width:20%!important}.lg\:\!w-\[75\%\]{width:75%!important}.lg\:\!w-fit{width:fit-content!important}.lg\:w-1\/2{width:50%}.lg\:w-1\/4{width:25%}.lg\:w-1\/5{width:20%}.lg\:w-12{width:3rem}.lg\:w-2\/3{width:66.666667%}.lg\:w-4\/5{width:80%}.lg\:w-\[100\%\]{width:100%}.lg\:w-\[19\.0625rem\]{width:19.0625rem}.lg\:w-\[22\.5rem\]{width:22.5rem}.lg\:w-\[25\%\]{width:25%}.lg\:w-\[31\.25rem\]{width:31.25rem}.lg\:w-\[315px\]{width:315px}.lg\:w-\[32rem\]{width:32rem}.lg\:w-\[33\%\]{width:33%}.lg\:w-\[333px\]{width:333px}.lg\:w-\[360px\]{width:360px}.lg\:w-\[50\%\]{width:50%}.lg\:w-fit{width:fit-content}.lg\:w-full{width:100%}.lg\:w-max{width:max-content}.lg\:\!min-w-\[40\%\]{min-width:40%!important}.lg\:max-w-2xl{max-width:42rem}.lg\:max-w-3xl{max-width:48rem}.lg\:max-w-4xl{max-width:56rem}.lg\:max-w-5xl{max-width:64rem}.lg\:max-w-6xl{max-width:72rem}.lg\:max-w-7xl{max-width:80rem}.lg\:max-w-\[28\.5rem\]{max-width:28.5rem}.lg\:max-w-\[30\%\]{max-width:30%}.lg\:max-w-\[32\%\]{max-width:32%}.lg\:max-w-\[80\%\]{max-width:80%}.lg\:max-w-lg{max-width:32rem}.lg\:max-w-md{max-width:28rem}.lg\:max-w-sm{max-width:24rem}.lg\:max-w-xl{max-width:36rem}.lg\:max-w-xs{max-width:20rem}.lg\:flex-1{flex:1 1 0%}.lg\:flex-auto{flex:1 1 auto}.lg\:flex-none{flex:none}.lg\:basis-1\/2{flex-basis:50%}.lg\:basis-1\/4{flex-basis:25%}.lg\:basis-\[15\.625rem\]{flex-basis:15.625rem}.lg\:list-disc{list-style-type:disc}.lg\:grid-cols-3{grid-template-columns:repeat(3,minmax(0,1fr))}.lg\:flex-row{flex-direction:row}.lg\:flex-row-reverse{flex-direction:row-reverse}.lg\:flex-col{flex-direction:column}.lg\:flex-wrap{flex-wrap:wrap}.lg\:flex-nowrap{flex-wrap:nowrap}.lg\:items-center{align-items:center}.lg\:justify-end{justify-content:flex-end}.lg\:justify-between{justify-content:space-between}.lg\:gap-0{gap:0}.lg\:gap-2xl{gap:var(--spacing-2xl)}.lg\:gap-lg{gap:var(--spacing-lg)}.lg\:gap-xl{gap:var(--spacing-xl)}.lg\:gap-x-lg{column-gap:var(--spacing-lg)}.lg\:gap-y-lg{row-gap:var(--spacing-lg)}.lg\:\!space-y-0>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0!important;margin-bottom:0!important;margin-bottom:calc(0px*var(--tw-space-y-reverse))!important;margin-top:0!important;margin-top:calc(0px*(1 - var(--tw-space-y-reverse)))!important}.lg\:space-x-lg>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:calc(var(--spacing-lg)*(1 - var(--tw-space-x-reverse)));margin-right:calc(var(--spacing-lg)*var(--tw-space-x-reverse))}.lg\:space-x-xl>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:calc(var(--spacing-xl)*(1 - var(--tw-space-x-reverse)));margin-right:calc(var(--spacing-xl)*var(--tw-space-x-reverse))}.lg\:space-y-0>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(0px*var(--tw-space-y-reverse));margin-top:0;margin-top:calc(0px*(1 - var(--tw-space-y-reverse)))}.lg\:space-y-2xl>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:calc(var(--spacing-2xl)*var(--tw-space-y-reverse));margin-top:calc(var(--spacing-2xl)*(1 - var(--tw-space-y-reverse)))}.lg\:rounded-2xl{border-radius:1rem}.lg\:rounded-3xl{border-radius:1.5rem}.lg\:border{border-width:1px}.lg\:border-0{border-width:0}.lg\:border-b{border-bottom-width:1px}.lg\:border-l{border-left-width:1px}.lg\:border-t-0{border-top-width:0}.lg\:border-none{border-style:none}.lg\:bg-surface-subtle{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.lg\:p-0{padding:0}.lg\:p-2xl{padding:var(--spacing-2xl)}.lg\:p-lg{padding:var(--spacing-lg)}.lg\:px-0{padding-left:0;padding-right:0}.lg\:px-10{padding-left:2.5rem;padding-right:2.5rem}.lg\:px-4{padding-left:1rem;padding-right:1rem}.lg\:px-4xl{padding-left:var(--spacing-4xl);padding-right:var(--spacing-4xl)}.lg\:px-\[\.9375rem\]{padding-left:.9375rem;padding-right:.9375rem}.lg\:px-lg{padding-left:var(--spacing-lg);padding-right:var(--spacing-lg)}.lg\:py-0{padding-bottom:0;padding-top:0}.lg\:py-10xl{padding-bottom:var(--spacing-10xl);padding-top:var(--spacing-10xl)}.lg\:py-12{padding-bottom:3rem;padding-top:3rem}.lg\:py-2xl{padding-bottom:var(--spacing-2xl);padding-top:var(--spacing-2xl)}.lg\:py-32{padding-bottom:8rem;padding-top:8rem}.lg\:py-3xl{padding-bottom:var(--spacing-3xl);padding-top:var(--spacing-3xl)}.lg\:py-4xl{padding-bottom:var(--spacing-4xl);padding-top:var(--spacing-4xl)}.lg\:py-5xl{padding-bottom:var(--spacing-5xl);padding-top:var(--spacing-5xl)}.lg\:py-7xl{padding-bottom:var(--spacing-7xl);padding-top:var(--spacing-7xl)}.lg\:py-lg{padding-bottom:var(--spacing-lg);padding-top:var(--spacing-lg)}.lg\:py-xl{padding-bottom:var(--spacing-xl);padding-top:var(--spacing-xl)}.lg\:pb-0{padding-bottom:0}.lg\:pb-2xl{padding-bottom:var(--spacing-2xl)}.lg\:pb-3xl{padding-bottom:var(--spacing-3xl)}.lg\:pb-5xl{padding-bottom:var(--spacing-5xl)}.lg\:pb-7xl{padding-bottom:var(--spacing-7xl)}.lg\:pb-\[12\.5rem\]{padding-bottom:12.5rem}.lg\:pb-\[6\.3125rem\]{padding-bottom:6.3125rem}.lg\:pb-lg{padding-bottom:var(--spacing-lg)}.lg\:pb-md{padding-bottom:var(--spacing-md)}.lg\:pb-sm{padding-bottom:var(--spacing-sm)}.lg\:pl-10{padding-left:2.5rem}.lg\:pl-2xl{padding-left:var(--spacing-2xl)}.lg\:pl-lg{padding-left:var(--spacing-lg)}.lg\:pl-sm{padding-left:var(--spacing-sm)}.lg\:pl-xl{padding-left:var(--spacing-xl)}.lg\:pr-0{padding-right:0}.lg\:pr-lg{padding-right:var(--spacing-lg)}.lg\:pr-xl{padding-right:var(--spacing-xl)}.lg\:pt-0{padding-top:0}.lg\:pt-2xl{padding-top:var(--spacing-2xl)}.lg\:pt-3xl{padding-top:var(--spacing-3xl)}.lg\:pt-5xl{padding-top:var(--spacing-5xl)}.lg\:pt-7xl{padding-top:var(--spacing-7xl)}.lg\:pt-\[5rem\]{padding-top:5rem}.lg\:pt-\[7\.5rem\]{padding-top:7.5rem}.lg\:pt-\[8\.125rem\]{padding-top:8.125rem}.lg\:pt-lg{padding-top:var(--spacing-lg)}.lg\:pt-md{padding-top:var(--spacing-md)}.lg\:pt-xl{padding-top:var(--spacing-xl)}.lg\:text-center{text-align:center}.lg\:\!text-3xl{font-size:1.875rem!important;line-height:2.25rem!important}}@media (min-width:1280px){.xl\:mr-7xl{margin-right:var(--spacing-7xl)}.xl\:mr-lg{margin-right:var(--spacing-lg)}.xl\:h-16{height:4rem}.xl\:w-16{width:4rem}.xl\:w-4{width:1rem}.xl\:w-\[100\%\]{width:100%}.xl\:w-\[25\%\]{width:25%}.xl\:w-\[27\.6875rem\]{width:27.6875rem}.xl\:w-\[33\%\]{width:33%}.xl\:w-\[50\%\]{width:50%}.xl\:space-x-3xl>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:calc(var(--spacing-3xl)*(1 - var(--tw-space-x-reverse)));margin-right:calc(var(--spacing-3xl)*var(--tw-space-x-reverse))}}@media (min-width:1440px){.xxl\:w-\[33\%\]{width:33%}}.\[\&\:\:-webkit-inner-spin-button\]\:appearance-none::-webkit-inner-spin-button,.\[\&\:\:-webkit-outer-spin-button\]\:appearance-none::-webkit-outer-spin-button{appearance:none}.\[\&\>a\]\:block>a{display:block}.\[\&\>a\]\:w-full>a{width:100%}.\[\&\>a\]\:px-2>a{padding-left:.5rem;padding-right:.5rem}.\[\&\>a\]\:px-4>a{padding-left:1rem;padding-right:1rem}.\[\&\>a\]\:py-md>a{padding-bottom:var(--spacing-md);padding-top:var(--spacing-md)}.\[\&\>div\]\:z-1>div{z-index:1}.\[\&\>div\]\:z-10>div{z-index:10}.\[\&\>div\]\:w-fit>div{width:fit-content}.\[\&\>ol\>li\]\:truncate>ol>li{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.\[\&\>span\]\:overflow-hidden>span{overflow:hidden}.\[\&\>span\]\:truncate>span{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.\[\&_input\]\:\!w-\[1\.15em\] input{width:1.15em!important}.\[\&_input\]\:text-center input{text-align:center}.\[\&_span\]\:hover\:text-color-brand-bold:hover span,.\[\&_span\]\:text-color-brand-bold span{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}</style> <style>@charset "UTF-8"; /*! tailwindcss v3.3.2 | MIT License | https://tailwindcss.com*/*,:after,:before{border:0 solid;box-sizing:border-box}:after,:before{--tw-content:""}html{line-height:1.5;-webkit-text-size-adjust:100%;font-family:Suisse Int\'l,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji;font-feature-settings:normal;font-variation-settings:normal;-moz-tab-size:4;-o-tab-size:4;tab-size:4}body{line-height:inherit;margin:0}hr{border-top-width:1px;color:inherit;height:0}abbr:where([title]){-webkit-text-decoration:underline dotted;text-decoration:underline dotted}h1,h2,h3,h4,h5,h6{font-size:inherit;font-weight:inherit}a{color:inherit;text-decoration:inherit}b,strong{font-weight:bolder}code,kbd,pre,samp{font-family:ui-monospace,SFMono-Regular,Menlo,Monaco,Consolas,Liberation Mono,Courier New,monospace;font-size:1em}small{font-size:80%}sub,sup{font-size:75%;line-height:0;position:relative;vertical-align:baseline}sub{bottom:-.25em}sup{top:-.5em}table{border-collapse:collapse;border-color:inherit;text-indent:0}button,input,optgroup,select,textarea{color:inherit;font-family:inherit;font-size:100%;font-weight:inherit;line-height:inherit;margin:0;padding:0}button,select{text-transform:none}[type=button],[type=reset],[type=submit],button{-webkit-appearance:button;background-color:transparent;background-image:none}:-moz-focusring{outline:auto}:-moz-ui-invalid{box-shadow:none}progress{vertical-align:baseline}::-webkit-inner-spin-button,::-webkit-outer-spin-button{height:auto}[type=search]{-webkit-appearance:textfield;outline-offset:-2px}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-file-upload-button{-webkit-appearance:button;font:inherit}summary{display:list-item}blockquote,dd,dl,figure,h1,h2,h3,h4,h5,h6,hr,p,pre{margin:0}fieldset{margin:0}fieldset,legend{padding:0}menu,ol,ul{list-style:none;margin:0;padding:0}textarea{resize:vertical}input::-moz-placeholder,textarea::-moz-placeholder{color:#9ca3af;opacity:1}input::placeholder,textarea::placeholder{color:#9ca3af;opacity:1}[role=button],button{cursor:pointer}:disabled{cursor:default}audio,canvas,embed,iframe,img,object,svg,video{display:block;vertical-align:middle}img,video{height:auto;max-width:100%}[hidden]{display:none}html{color:0,0,0;color:var(--color-text-default)}:root{--color-blue-000:233,241,255;--color-blue-100:208,228,255;--color-blue-200:155,203,255;--color-blue-300:105,176,245;--color-blue-400:76,149,216;--color-blue-500:51,122,183;--color-blue-600:0,98,159;--color-blue-700:0,88,144;--color-blue-800:0,74,121;--color-blue-900:0,50,86;--color-blue-1000:0,29,52;--color-red-000:255,251,255;--color-red-100:255,218,212;--color-red-200:255,180,166;--color-red-300:255,138,117;--color-red-400:255,85,59;--color-red-500:225,25,0;--color-red-600:211,28,4;--color-red-700:189,19,0;--color-red-800:144,12,0;--color-red-900:103,6,0;--color-red-1000:64,2,0;--color-yellow-000:254,252,232;--color-yellow-100:254,249,195;--color-yellow-200:254,240,138;--color-yellow-300:253,224,71;--color-yellow-400:250,204,21;--color-yellow-500:234,179,8;--color-yellow-600:209,149,7;--color-yellow-700:196,132,4;--color-yellow-800:168,106,7;--color-yellow-900:143,87,13;--color-yellow-1000:125,75,17;--color-green-000:241,254,248;--color-green-100:191,238,215;--color-green-200:101,214,160;--color-green-300:60,194,129;--color-green-400:34,173,106;--color-green-500:5,148,79;--color-green-600:9,133,73;--color-green-700:0,109,56;--color-green-800:0,82,41;--color-green-900:0,57,26;--color-green-1000:0,33,13;--color-cyan-000:245,251,255;--color-cyan-100:220,243,255;--color-cyan-200:195,234,254;--color-cyan-300:170,224,253;--color-cyan-400:145,214,251;--color-cyan-500:89,186,240;--color-cyan-600:44,154,207;--color-cyan-700:0,127,176;--color-cyan-800:0,101,141;--color-cyan-900:0,76,107;--color-cyan-1000:0,52,75;--color-neutral-000:248,249,253;--color-neutral-100:247,248,249;--color-neutral-200:241,242,244;--color-neutral-300:220,223,228;--color-neutral-400:179,185,196;--color-neutral-500:133,144,162;--color-neutral-600:117,129,149;--color-neutral-700:98,111,134;--color-neutral-800:68,84,111;--color-neutral-900:44,62,93;--color-neutral-1000:23,43,77;--color-white:255,255,255;--color-black:0,0,0;--color-brand-sunken:var(--color-yellow-000);--color-brand-subtlest:var(--color-yellow-100);--color-brand-subtler:var(--color-yellow-200);--color-brand-subtle:var(--color-yellow-300);--color-brand-default:var(--color-yellow-400);--color-brand-bold:var(--color-yellow-500);--color-brand-bolder:var(--color-yellow-600);--color-brand-boldest:var(--color-yellow-700);--color-brand-strong:var(--color-yellow-800);--color-brand-stronger:var(--color-yellow-900);--color-brand-strongest:var(--color-yellow-1000);--color-accent-sunken:var(--color-black);--color-accent-subtlest:var(--color-black);--color-accent-subtler:var(--color-black);--color-accent-subtle:var(--color-black);--color-accent-default:var(--color-black);--color-accent-bold:var(--color-black);--color-accent-bolder:var(--color-black);--color-accent-boldest:var(--color-black);--color-accent-strong:var(--color-black);--color-accent-stronger:var(--color-black);--color-accent-strongest:var(--color-black);--color-error-sunken:var(--color-red-000);--color-error-subtlest:var(--color-red-100);--color-error-bold:var(--color-red-500);--color-warning-sunken:var(--color-yellow-000);--color-warning-subtlest:var(--color-yellow-100);--color-warning-bold:var(--color-yellow-500);--color-success-sunken:var(--color-green-000);--color-success-subtlest:var(--color-green-100);--color-success-bold:var(--color-green-500);--color-info-sunken:var(--color-cyan-000);--color-info-subtlest:var(--color-cyan-100);--color-info-bold:var(--color-cyan-500);--color-link-bold:1,86,206;--color-link-bolder:1,75,181;--color-link-boldest:1,65,155;--color-text-default:var(--color-black);--color-text-subtle:var(--color-neutral-700);--color-text-subtlest:var(--color-neutral-600);--color-text-disabled:var(--color-neutral-400);--color-text-inverse:var(--color-white);--color-text-onbrand:var(--color-white);--color-text-onaccent:var(--color-white);--color-text-brand-bold:var(--color-brand-bold);--color-text-brand-bolder:var(--color-brand-bolder);--color-text-brand-boldest:var(--color-brand-boldest);--color-text-accent-bold:var(--color-white);--color-text-accent-bolder:var(--color-white);--color-text-accent-boldest:var(--color-white);--color-text-link-bold:var(--color-link-bold);--color-text-link-bolder:var(--color-link-bolder);--color-text-link-boldest:var(--color-link-boldest);--color-text-link-subtle:var(--color-neutral-700);--color-text-error:var(--color-red-600);--color-text-warning:var(--color-yellow-600);--color-text-success:var(--color-green-600);--color-text-info:var(--color-cyan-600);--color-surface-subtle:var(--color-neutral-000);--color-surface-default:var(--color-white);--color-surface-inverse:var(--color-black);--color-surface-selected:var(--color-neutral-000);--color-surface-disabled:var(--color-neutral-200);--color-bg-brand-sunken:var(--color-brand-sunken);--color-bg-brand-subtlest:var(--color-brand-subtlest);--color-bg-brand-subtler:var(--color-brand-subtler);--color-bg-brand-subtle:var(--color-brand-subtle);--color-bg-brand-default:var(--color-brand-default);--color-bg-brand-bold:var(--color-brand-bold);--color-bg-brand-bolder:var(--color-brand-bolder);--color-bg-brand-boldest:var(--color-brand-boldest);--color-bg-brand-strong:var(--color-brand-strong);--color-bg-brand-stronger:var(--color-brand-stronger);--color-bg-brand-strongest:var(--color-brand-strongest);--color-bg-accent-sunken:var(--color-accent-sunken);--color-bg-accent-subtlest:var(--color-accent-subtlest);--color-bg-accent-subtler:var(--color-accent-subtler);--color-bg-accent-subtle:var(--color-accent-subtle);--color-bg-accent-default:var(--color-accent-default);--color-bg-accent-bold:var(--color-accent-bold);--color-bg-accent-bolder:var(--color-accent-bolder);--color-bg-accent-boldest:var(--color-accent-boldest);--color-bg-accent-strong:var(--color-accent-strong);--color-bg-accent-stronger:var(--color-accent-stronger);--color-bg-accent-strongest:var(--color-accent-strongest);--color-bg-content-sunken:var(--color-brand-sunken);--color-bg-content-subtlest:var(--color-brand-subtlest);--color-bg-content-subtler:var(--color-brand-subtler);--color-bg-content-subtle:var(--color-brand-subtle);--color-bg-content-default:var(--color-brand-default);--color-bg-content-bold:var(--color-brand-bold);--color-bg-content-bolder:var(--color-brand-bolder);--color-bg-content-boldest:var(--color-brand-boldest);--color-bg-content-inverse-subtler:var(--color-brand-strong);--color-bg-content-inverse-subtle:var(--color-brand-stronger);--color-bg-content-inverse:var(--color-brand-strongest);--color-bg-error-sunken:var(--color-error-sunken);--color-bg-error-subtlest:var(--color-error-subtlest);--color-bg-error-bold:var(--color-error-bold);--color-bg-warning-sunken:var(--color-warning-sunken);--color-bg-warning-subtlest:var(--color-warning-subtlest);--color-bg-warning-bold:var(--color-warning-bold);--color-bg-success-sunken:var(--color-success-sunken);--color-bg-success-subtlest:var(--color-success-subtlest);--color-bg-success-bold:var(--color-success-bold);--color-bg-info-sunken:var(--color-info-sunken);--color-bg-info-subtlest:var(--color-info-subtlest);--color-bg-info-bold:var(--color-info-bold);--color-border-default:var(--color-neutral-300);--color-border-bold:var(--color-neutral-400);--color-border-brand:var(--color-brand-bold);--color-border-selected:var(--color-brand-bold);--color-border-error:var(--color-error-bold);--color-border-warning:var(--color-warning-bold);--color-border-success:var(--color-success-bold);--color-border-info:var(--color-info-bold);--spacing-xs:0.25rem;--spacing-sm:0.5rem;--spacing-md:1rem;--spacing-lg:1.5rem;--spacing-xl:2rem;--spacing-2xl:2.5rem;--spacing-3xl:3rem;--spacing-4xl:3.5rem;--spacing-5xl:4rem;--spacing-6xl:4.5rem;--spacing-7xl:5rem;--spacing-8xl:5.5rem;--spacing-9xl:6rem;--spacing-10xl:6.5rem;--h1-lg-size:3.75rem;--h1-md-size:3rem;--h1-sm-size:2.25rem;--h2-lg-size:3rem;--h2-md-size:2.25rem;--h2-sm-size:1.875rem;--h3-lg-size:2.375rem;--h3-md-size:1.875rem;--h3-sm-size:1.5rem;--h4-lg-size:1.875rem;--h4-md-size:1.5rem;--h4-sm-size:1.25rem;--h5-lg-size:1.25rem;--h5-md-size:1.125rem;--h5-sm-size:1rem;--h6-lg-size:1.125rem;--h6-md-size:1rem;--h6-sm-size:0.875rem;--h1-lg-line-height:1;--h1-md-line-height:1;--h1-sm-line-height:1.11;--h2-lg-line-height:1.2;--h2-md-line-height:1.11;--h2-sm-line-height:1.2;--h3-lg-line-height:1.3;--h3-md-line-height:1.2;--h3-sm-line-height:1.33;--h4-lg-line-height:1.3;--h4-md-line-height:1.33;--h4-sm-line-height:1.4;--h5-lg-line-height:1.5;--h5-md-line-height:1.55;--h5-sm-line-height:1.5;--h6-lg-line-height:1.55;--h6-md-line-height:1.5;--h6-sm-line-height:1.5}.m-switch{--color-brand-default:35,35,35;--color-bg-content-default:var(--color-neutral-400);--color-bg-content-bold:var(--color-neutral-500);--color-bg-content-bolder:var(--color-neutral-600);--color-brand-bold:var(--color-black);--color-brand-bolder:var(--color-black)}.m-checkbox{--color-brand-bold:0,0,0;--color-border-brand:0,0,0;--color-brand-default:0,0,0}.m-autocomplete,.m-select{--color-text-brand-bold:0,0,0;--color-text-brand-bolder:0,0,0}.m-range-slider{--color-brand-bold:0,0,0;--color-brand-bolder:0,0,0;--color-brand-strong:0,0,0;--color-bg-content-default:var(--color-border-default)}.m-tag{--color-text-brand-bold:0,0,0}.m-chip{--color-text-brand-bolder:0,0,0}.m-dropdown,.m-list,.m-notification,.m-tabs{--color-text-brand-bold:0,0,0}.m-tabs__header{--color-bg-content-subtle:var(--color-border-default)}.m-loader{--color-brand-bold:0,0,0;--color-brand-sunken:var(--color-neutral-100)}.m-search-select{--color-surface-selected:var(--color-brand-default);--color-surface-subtle:var(--color-white);--color-text-brand-bold:var(--color-black)}.m-button-group>.m-button--active{--color-brand-strong:var(--color-black);--color-text-on-brand:var(--color-white)}.m-radio-group{--color-border-brand:0,0,0;--color-brand-bold:0,0,0;--color-brand-bolder:0,0,0;--color-brand-boldest:0,0,0}.m-stepper{--color-surface-selected:var(--color-bg-brand-boldest);--color-text-brand-bold:var(--color-black);--color-brand-bold:var(--color-bg-brand-subtler);--color-white:var(--color-text-subtle);--color-brand-default:var(--color-bg-brand-subtlest);--color-text-default:var(--color-text-subtle)}.m-stepper__line{--color-brand-bold:var(--color-black);--color-bg-content-default:var(--color-border-bold)}.m-feature{--color-text-brand-bolder:var(--color-brand-default)}*,:after,:before{--tw-border-spacing-x:0;--tw-border-spacing-y:0;--tw-translate-x:0;--tw-translate-y:0;--tw-rotate:0;--tw-skew-x:0;--tw-skew-y:0;--tw-scale-x:1;--tw-scale-y:1;--tw-pan-x: ;--tw-pan-y: ;--tw-pinch-zoom: ;--tw-scroll-snap-strictness:proximity;--tw-gradient-from-position: ;--tw-gradient-via-position: ;--tw-gradient-to-position: ;--tw-ordinal: ;--tw-slashed-zero: ;--tw-numeric-figure: ;--tw-numeric-spacing: ;--tw-numeric-fraction: ;--tw-ring-inset: ;--tw-ring-offset-width:0px;--tw-ring-offset-color:#fff;--tw-ring-color:rgba(59,130,246,.5);--tw-ring-offset-shadow:0 0 #0000;--tw-ring-shadow:0 0 #0000;--tw-shadow:0 0 #0000;--tw-shadow-colored:0 0 #0000;--tw-blur: ;--tw-brightness: ;--tw-contrast: ;--tw-grayscale: ;--tw-hue-rotate: ;--tw-invert: ;--tw-saturate: ;--tw-sepia: ;--tw-drop-shadow: ;--tw-backdrop-blur: ;--tw-backdrop-brightness: ;--tw-backdrop-contrast: ;--tw-backdrop-grayscale: ;--tw-backdrop-hue-rotate: ;--tw-backdrop-invert: ;--tw-backdrop-opacity: ;--tw-backdrop-saturate: ;--tw-backdrop-sepia: }::backdrop{--tw-border-spacing-x:0;--tw-border-spacing-y:0;--tw-translate-x:0;--tw-translate-y:0;--tw-rotate:0;--tw-skew-x:0;--tw-skew-y:0;--tw-scale-x:1;--tw-scale-y:1;--tw-pan-x: ;--tw-pan-y: ;--tw-pinch-zoom: ;--tw-scroll-snap-strictness:proximity;--tw-gradient-from-position: ;--tw-gradient-via-position: ;--tw-gradient-to-position: ;--tw-ordinal: ;--tw-slashed-zero: ;--tw-numeric-figure: ;--tw-numeric-spacing: ;--tw-numeric-fraction: ;--tw-ring-inset: ;--tw-ring-offset-width:0px;--tw-ring-offset-color:#fff;--tw-ring-color:rgba(59,130,246,.5);--tw-ring-offset-shadow:0 0 #0000;--tw-ring-shadow:0 0 #0000;--tw-shadow:0 0 #0000;--tw-shadow-colored:0 0 #0000;--tw-blur: ;--tw-brightness: ;--tw-contrast: ;--tw-grayscale: ;--tw-hue-rotate: ;--tw-invert: ;--tw-saturate: ;--tw-sepia: ;--tw-drop-shadow: ;--tw-backdrop-blur: ;--tw-backdrop-brightness: ;--tw-backdrop-contrast: ;--tw-backdrop-grayscale: ;--tw-backdrop-hue-rotate: ;--tw-backdrop-invert: ;--tw-backdrop-opacity: ;--tw-backdrop-saturate: ;--tw-backdrop-sepia: }.container{width:100%}@media (min-width:576px){.container{max-width:576px}}@media (min-width:768px){.container{max-width:768px}}@media (min-width:1024px){.container{max-width:1024px}}@media (min-width:1280px){.container{max-width:1280px}}@media (min-width:1440px){.container{max-width:1440px}}@media (min-width:1920px){.container{max-width:1920px}}.prose{color:var(--tw-prose-body);max-width:65ch}.prose :where(p):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em;margin-top:1.25em}.prose :where([class~=lead]):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-lead);font-size:1.25em;line-height:1.6;margin-bottom:1.2em;margin-top:1.2em}.prose :where(a):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-links);font-weight:500;text-decoration:underline}.prose :where(strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-bold);font-weight:600}.prose :where(a strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(blockquote strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(thead th strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(ol):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:decimal;margin-bottom:1.25em;margin-top:1.25em;padding-inline-start:1.625em}.prose :where(ol[type=A]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-alpha}.prose :where(ol[type=a]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-alpha}.prose :where(ol[type=A s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-alpha}.prose :where(ol[type=a s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-alpha}.prose :where(ol[type=I]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-roman}.prose :where(ol[type=i]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-roman}.prose :where(ol[type=I s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:upper-roman}.prose :where(ol[type=i s]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:lower-roman}.prose :where(ol[type="1"]):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:decimal}.prose :where(ul):not(:where([class~=not-prose],[class~=not-prose] *)){list-style-type:disc;margin-bottom:1.25em;margin-top:1.25em;padding-inline-start:1.625em}.prose :where(ol>li):not(:where([class~=not-prose],[class~=not-prose] *))::marker{color:var(--tw-prose-counters);font-weight:400}.prose :where(ul>li):not(:where([class~=not-prose],[class~=not-prose] *))::marker{color:var(--tw-prose-bullets)}.prose :where(dt):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-weight:600;margin-top:1.25em}.prose :where(hr):not(:where([class~=not-prose],[class~=not-prose] *)){border-color:var(--tw-prose-hr);border-top-width:1px;margin-bottom:3em;margin-top:3em}.prose :where(blockquote):not(:where([class~=not-prose],[class~=not-prose] *)){border-inline-start-color:var(--tw-prose-quote-borders);border-inline-start-width:.25rem;color:var(--tw-prose-quotes);font-style:italic;font-weight:500;margin-bottom:1.6em;margin-top:1.6em;padding-inline-start:1em;quotes:"\201C""\201D""\2018""\2019"}.prose :where(blockquote p:first-of-type):not(:where([class~=not-prose],[class~=not-prose] *)):before{content:open-quote}.prose :where(blockquote p:last-of-type):not(:where([class~=not-prose],[class~=not-prose] *)):after{content:close-quote}.prose :where(h1):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-size:2.25em;font-weight:800;line-height:1.1111111;margin-bottom:.8888889em;margin-top:0}.prose :where(h1 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:900}.prose :where(h2):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-size:1.5em;font-weight:700;line-height:1.3333333;margin-bottom:1em;margin-top:2em}.prose :where(h2 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:800}.prose :where(h3):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-size:1.25em;font-weight:600;line-height:1.6;margin-bottom:.6em;margin-top:1.6em}.prose :where(h3 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:700}.prose :where(h4):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-weight:600;line-height:1.5;margin-bottom:.5em;margin-top:1.5em}.prose :where(h4 strong):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-weight:700}.prose :where(img):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:2em;margin-top:2em}.prose :where(picture):not(:where([class~=not-prose],[class~=not-prose] *)){display:block;margin-bottom:2em;margin-top:2em}.prose :where(video):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:2em;margin-top:2em}.prose :where(kbd):not(:where([class~=not-prose],[class~=not-prose] *)){border-radius:.3125rem;box-shadow:0 0 0 1px rgb(var(--tw-prose-kbd-shadows)/10%),0 3px 0 rgb(var(--tw-prose-kbd-shadows)/10%);color:var(--tw-prose-kbd);font-family:inherit;font-size:.875em;font-weight:500;padding-inline-end:.375em;padding-bottom:.1875em;padding-top:.1875em;padding-inline-start:.375em}.prose :where(code):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-code);font-size:.875em;font-weight:600}.prose :where(code):not(:where([class~=not-prose],[class~=not-prose] *)):before{content:"`"}.prose :where(code):not(:where([class~=not-prose],[class~=not-prose] *)):after{content:"`"}.prose :where(a code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(h1 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(h2 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-size:.875em}.prose :where(h3 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit;font-size:.9em}.prose :where(h4 code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(blockquote code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(thead th code):not(:where([class~=not-prose],[class~=not-prose] *)){color:inherit}.prose :where(pre):not(:where([class~=not-prose],[class~=not-prose] *)){background-color:var(--tw-prose-pre-bg);border-radius:.375rem;color:var(--tw-prose-pre-code);font-size:.875em;font-weight:400;line-height:1.7142857;margin-bottom:1.7142857em;margin-top:1.7142857em;overflow-x:auto;padding-inline-end:1.1428571em;padding-bottom:.8571429em;padding-top:.8571429em;padding-inline-start:1.1428571em}.prose :where(pre code):not(:where([class~=not-prose],[class~=not-prose] *)){background-color:transparent;border-radius:0;border-width:0;color:inherit;font-family:inherit;font-size:inherit;font-weight:inherit;line-height:inherit;padding:0}.prose :where(pre code):not(:where([class~=not-prose],[class~=not-prose] *)):before{content:none}.prose :where(pre code):not(:where([class~=not-prose],[class~=not-prose] *)):after{content:none}.prose :where(table):not(:where([class~=not-prose],[class~=not-prose] *)){font-size:.875em;line-height:1.7142857;margin-bottom:2em;margin-top:2em;table-layout:auto;width:100%}.prose :where(thead):not(:where([class~=not-prose],[class~=not-prose] *)){border-bottom-color:var(--tw-prose-th-borders);border-bottom-width:1px}.prose :where(thead th):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-headings);font-weight:600;padding-inline-end:.5714286em;padding-bottom:.5714286em;padding-inline-start:.5714286em;vertical-align:bottom}.prose :where(tbody tr):not(:where([class~=not-prose],[class~=not-prose] *)){border-bottom-color:var(--tw-prose-td-borders);border-bottom-width:1px}.prose :where(tbody tr:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){border-bottom-width:0}.prose :where(tbody td):not(:where([class~=not-prose],[class~=not-prose] *)){vertical-align:baseline}.prose :where(tfoot):not(:where([class~=not-prose],[class~=not-prose] *)){border-top-color:var(--tw-prose-th-borders);border-top-width:1px}.prose :where(tfoot td):not(:where([class~=not-prose],[class~=not-prose] *)){vertical-align:top}.prose :where(th,td):not(:where([class~=not-prose],[class~=not-prose] *)){text-align:start}.prose :where(figure>*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:0;margin-top:0}.prose :where(figcaption):not(:where([class~=not-prose],[class~=not-prose] *)){color:var(--tw-prose-captions);font-size:.875em;line-height:1.4285714;margin-top:.8571429em}.prose{--tw-prose-body:#374151;--tw-prose-headings:#111827;--tw-prose-lead:#4b5563;--tw-prose-links:#111827;--tw-prose-bold:#111827;--tw-prose-counters:#6b7280;--tw-prose-bullets:#d1d5db;--tw-prose-hr:#e5e7eb;--tw-prose-quotes:#111827;--tw-prose-quote-borders:#e5e7eb;--tw-prose-captions:#6b7280;--tw-prose-kbd:#111827;--tw-prose-kbd-shadows:17 24 39;--tw-prose-code:#111827;--tw-prose-pre-code:#e5e7eb;--tw-prose-pre-bg:#1f2937;--tw-prose-th-borders:#d1d5db;--tw-prose-td-borders:#e5e7eb;--tw-prose-invert-body:#d1d5db;--tw-prose-invert-headings:#fff;--tw-prose-invert-lead:#9ca3af;--tw-prose-invert-links:#fff;--tw-prose-invert-bold:#fff;--tw-prose-invert-counters:#9ca3af;--tw-prose-invert-bullets:#4b5563;--tw-prose-invert-hr:#374151;--tw-prose-invert-quotes:#f3f4f6;--tw-prose-invert-quote-borders:#374151;--tw-prose-invert-captions:#9ca3af;--tw-prose-invert-kbd:#fff;--tw-prose-invert-kbd-shadows:255 255 255;--tw-prose-invert-code:#fff;--tw-prose-invert-pre-code:#d1d5db;--tw-prose-invert-pre-bg:rgba(0,0,0,.5);--tw-prose-invert-th-borders:#4b5563;--tw-prose-invert-td-borders:#374151;font-size:1rem;line-height:1.75}.prose :where(picture>img):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:0;margin-top:0}.prose :where(li):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:.5em;margin-top:.5em}.prose :where(ol>li):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:.375em}.prose :where(ul>li):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:.375em}.prose :where(.prose>ul>li p):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:.75em;margin-top:.75em}.prose :where(.prose>ul>li>p:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:1.25em}.prose :where(.prose>ul>li>p:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em}.prose :where(.prose>ol>li>p:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:1.25em}.prose :where(.prose>ol>li>p:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em}.prose :where(ul ul,ul ol,ol ul,ol ol):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:.75em;margin-top:.75em}.prose :where(dl):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:1.25em;margin-top:1.25em}.prose :where(dd):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:.5em;padding-inline-start:1.625em}.prose :where(hr+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(h2+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(h3+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(h4+*):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(thead th:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:0}.prose :where(thead th:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-end:0}.prose :where(tbody td,tfoot td):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-end:.5714286em;padding-bottom:.5714286em;padding-top:.5714286em;padding-inline-start:.5714286em}.prose :where(tbody td:first-child,tfoot td:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-start:0}.prose :where(tbody td:last-child,tfoot td:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){padding-inline-end:0}.prose :where(figure):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:2em;margin-top:2em}.prose :where(.prose>:first-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-top:0}.prose :where(.prose>:last-child):not(:where([class~=not-prose],[class~=not-prose] *)){margin-bottom:0}.sr-only{height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px;clip:rect(0,0,0,0);border-width:0;white-space:nowrap}.pointer-events-none{pointer-events:none}.visible{visibility:visible}.invisible{visibility:hidden}.collapse{visibility:collapse}.static{position:static}.fixed{position:fixed}.\!absolute{position:absolute!important}.absolute{position:absolute}.relative{position:relative}.sticky{position:sticky}.inset-0{inset:0}.inset-y-0{bottom:0;top:0}.-top-px{top:-1px}.bottom-0{bottom:0}.bottom-1{bottom:.25rem}.bottom-1\.5{bottom:.375rem}.bottom-10{bottom:2.5rem}.bottom-24{bottom:6rem}.bottom-4{bottom:1rem}.bottom-6{bottom:1.5rem}.bottom-\[7\.5rem\]{bottom:7.5rem}.bottom-md{bottom:1rem;bottom:var(--spacing-md)}.left-0{left:0}.left-1\/2{left:50%}.left-12{left:3rem}.left-4{left:1rem}.left-6{left:1.5rem}.left-md{left:1rem;left:var(--spacing-md)}.right-0{right:0}.right-1{right:.25rem}.right-1\.5{right:.375rem}.right-12{right:3rem}.right-2{right:.5rem}.right-2\.5{right:.625rem}.right-4{right:1rem}.right-6{right:1.5rem}.right-8{right:2rem}.right-\[-10px\]{right:-10px}.right-\[-4px\]{right:-4px}.right-\[-8px\]{right:-8px}.right-\[1rem\]{right:1rem}.right-\[3\.125rem\]{right:3.125rem}.top-0{top:0}.top-1{top:.25rem}.top-1\/2{top:50%}.top-12{top:3rem}.top-14{top:3.5rem}.top-16{top:4rem}.top-20{top:5rem}.top-4{top:1rem}.top-6{top:1.5rem}.top-\[-4px\]{top:-4px}.top-\[-5\.875rem\]{top:-5.875rem}.top-\[4\.625rem\]{top:4.625rem}.top-\[48\%\]{top:48%}.top-\[calc$50vh\+15rem$\]{top:calc(50vh + 15rem)}.top-\[calc$50vh\+6\.25rem$\]{top:calc(50vh + 6.25rem)}.isolate{isolation:isolate}.-z-10{z-index:-10}.z-0{z-index:0}.z-1{z-index:1}.z-10{z-index:10}.z-20{z-index:20}.z-40{z-index:40}.z-50{z-index:50}.float-left{float:left}.clear-left{clear:left}.m-0{margin:0}.m-\[\.625rem\]{margin:.625rem}.m-auto{margin:auto}.m-md{margin:1rem;margin:var(--spacing-md)}.mx-auto{margin-left:auto;margin-right:auto}.mx-lg{margin-left:1.5rem;margin-left:var(--spacing-lg);margin-right:1.5rem;margin-right:var(--spacing-lg)}.mx-md{margin-left:1rem;margin-left:var(--spacing-md);margin-right:1rem;margin-right:var(--spacing-md)}.mx-sm{margin-left:.5rem;margin-left:var(--spacing-sm);margin-right:.5rem;margin-right:var(--spacing-sm)}.my-0{margin-bottom:0;margin-top:0}.my-2xl{margin-bottom:2.5rem;margin-bottom:var(--spacing-2xl);margin-top:2.5rem;margin-top:var(--spacing-2xl)}.my-4{margin-bottom:1rem;margin-top:1rem}.my-5xl{margin-bottom:4rem;margin-bottom:var(--spacing-5xl);margin-top:4rem;margin-top:var(--spacing-5xl)}.my-lg{margin-bottom:1.5rem;margin-bottom:var(--spacing-lg);margin-top:1.5rem;margin-top:var(--spacing-lg)}.my-md{margin-bottom:1rem;margin-bottom:var(--spacing-md);margin-top:1rem;margin-top:var(--spacing-md)}.my-sm{margin-bottom:.5rem;margin-bottom:var(--spacing-sm);margin-top:.5rem;margin-top:var(--spacing-sm)}.my-xl{margin-bottom:2rem;margin-bottom:var(--spacing-xl);margin-top:2rem;margin-top:var(--spacing-xl)}.-mr-0{margin-right:0}.-mr-0\.5{margin-right:-.125rem}.-mr-1{margin-right:-.25rem}.-mr-2{margin-right:-.5rem}.-mr-2\.5{margin-right:-.625rem}.-mt-xs{margin-top:-.25rem;margin-top:calc(var(--spacing-xs)*-1)}.mb-1{margin-bottom:.25rem}.mb-2{margin-bottom:.5rem}.mb-2xl{margin-bottom:2.5rem;margin-bottom:var(--spacing-2xl)}.mb-3{margin-bottom:.75rem}.mb-4{margin-bottom:1rem}.mb-6{margin-bottom:1.5rem}.mb-7xl{margin-bottom:5rem;margin-bottom:var(--spacing-7xl)}.mb-\[0\.25rem\]{margin-bottom:.25rem}.mb-lg{margin-bottom:1.5rem;margin-bottom:var(--spacing-lg)}.mb-md{margin-bottom:1rem;margin-bottom:var(--spacing-md)}.mb-sm{margin-bottom:.5rem;margin-bottom:var(--spacing-sm)}.mb-xl{margin-bottom:2rem;margin-bottom:var(--spacing-xl)}.mb-xs{margin-bottom:.25rem;margin-bottom:var(--spacing-xs)}.ml-2{margin-left:.5rem}.ml-2xl{margin-left:2.5rem;margin-left:var(--spacing-2xl)}.ml-\[-0\.0625rem\]{margin-left:-.0625rem}.ml-\[-0\.75rem\]{margin-left:-.75rem}.ml-\[0\.625rem\]{margin-left:.625rem}.ml-\[0\.75rem\]{margin-left:.75rem}.ml-auto{margin-left:auto}.ml-lg{margin-left:1.5rem;margin-left:var(--spacing-lg)}.ml-md{margin-left:1rem;margin-left:var(--spacing-md)}.ml-sm{margin-left:.5rem;margin-left:var(--spacing-sm)}.ml-xs{margin-left:.25rem;margin-left:var(--spacing-xs)}.mr-4{margin-right:1rem}.mr-5{margin-right:1.25rem}.mr-6{margin-right:1.5rem}.mr-\[\.125rem\]{margin-right:.125rem}.mr-\[\.625rem\]{margin-right:.625rem}.mr-\[0\.3125rem\]{margin-right:.3125rem}.mr-\[2\.3125rem\]{margin-right:2.3125rem}.mr-\[2\.375rem\]{margin-right:2.375rem}.mr-\[5\.625rem\]{margin-right:5.625rem}.mr-lg{margin-right:1.5rem;margin-right:var(--spacing-lg)}.mr-md{margin-right:1rem;margin-right:var(--spacing-md)}.mr-sm{margin-right:.5rem;margin-right:var(--spacing-sm)}.mr-xl{margin-right:2rem;margin-right:var(--spacing-xl)}.mr-xs{margin-right:.25rem;margin-right:var(--spacing-xs)}.mt-1{margin-top:.25rem}.mt-2xl{margin-top:2.5rem;margin-top:var(--spacing-2xl)}.mt-3xl{margin-top:3rem;margin-top:var(--spacing-3xl)}.mt-6{margin-top:1.5rem}.mt-\[-3rem\]{margin-top:-3rem}.mt-\[\.625rem\]{margin-top:.625rem}.mt-\[1\.25rem\]{margin-top:1.25rem}.mt-\[1rem\]{margin-top:1rem}.mt-lg{margin-top:1.5rem;margin-top:var(--spacing-lg)}.mt-md{margin-top:1rem;margin-top:var(--spacing-md)}.mt-sm{margin-top:.5rem;margin-top:var(--spacing-sm)}.mt-xl{margin-top:2rem;margin-top:var(--spacing-xl)}.mt-xs{margin-top:.25rem;margin-top:var(--spacing-xs)}.box-border{box-sizing:border-box}.line-clamp-1{-webkit-line-clamp:1}.line-clamp-1,.line-clamp-3{display:-webkit-box;overflow:hidden;-webkit-box-orient:vertical}.line-clamp-3{-webkit-line-clamp:3}.\!block{display:block!important}.block{display:block}.\!inline-block{display:inline-block!important}.inline-block{display:inline-block}.\!inline{display:inline!important}.inline{display:inline}.flex{display:flex}.\!inline-flex{display:inline-flex!important}.inline-flex{display:inline-flex}.table{display:table}.grid{display:grid}.contents{display:contents}.\!hidden{display:none!important}.hidden{display:none}.aspect-\[1\/1\.414\]{aspect-ratio:1/1.414}.aspect-\[1200\/630\]{aspect-ratio:1200/630}.aspect-\[381\/200\]{aspect-ratio:381/200}.aspect-\[4\/5\]{aspect-ratio:4/5}.aspect-square{aspect-ratio:1/1}.aspect-video{aspect-ratio:16/9}.\!h-6{height:1.5rem!important}.h-0{height:0}.h-0\.5{height:.125rem}.h-1{height:.25rem}.h-1\.5{height:.375rem}.h-10{height:2.5rem}.h-12{height:3rem}.h-14{height:3.5rem}.h-16{height:4rem}.h-2{height:.5rem}.h-20{height:5rem}.h-28{height:7rem}.h-3{height:.75rem}.h-32{height:8rem}.h-36{height:9rem}.h-4{height:1rem}.h-48{height:12rem}.h-5{height:1.25rem}.h-52{height:13rem}.h-6{height:1.5rem}.h-7{height:1.75rem}.h-8{height:2rem}.h-80{height:20rem}.h-9{height:2.25rem}.h-96{height:24rem}.h-\[\.25rem\]{height:.25rem}.h-\[0\.5rem\]{height:.5rem}.h-\[0\.9rem\]{height:.9rem}.h-\[1\.15em\]{height:1.15em}.h-\[1\.3rem\]{height:1.3rem}.h-\[1\.4rem\]{height:1.4rem}.h-\[1\.5rem\]{height:1.5rem}.h-\[1\.8125rem\]{height:1.8125rem}.h-\[1\.875rem\]{height:1.875rem}.h-\[100\%\]{height:100%}.h-\[100px\]{height:100px}.h-\[150px\]{height:150px}.h-\[160px\]{height:160px}.h-\[1rem\]{height:1rem}.h-\[2\.5rem\]{height:2.5rem}.h-\[24rem\]{height:24rem}.h-\[25\.25rem\]{height:25.25rem}.h-\[3\.625rem\]{height:3.625rem}.h-\[3\.75rem\]{height:3.75rem}.h-\[30rem\]{height:30rem}.h-\[35\.5rem\]{height:35.5rem}.h-\[38rem\]{height:38rem}.h-\[4\.5rem\]{height:4.5rem}.h-\[50rem\]{height:50rem}.h-\[5rem\]{height:5rem}.h-\[6\.5rem\]{height:6.5rem}.h-\[6px\]{height:6px}.h-\[auto\],.h-auto{height:auto}.h-fit{height:-moz-fit-content;height:fit-content}.h-full{height:100%}.h-px{height:1px}.max-h-60{max-height:15rem}.max-h-80{max-height:20rem}.min-h-\[1\.5rem\]{min-height:1.5rem}.min-h-\[100px\]{min-height:100px}.min-h-\[15vh\]{min-height:15vh}.min-h-\[45rem\]{min-height:45rem}.min-h-\[70vh\]{min-height:70vh}.min-h-full{min-height:100%}.\!w-2xl{width:2.5rem!important;width:var(--spacing-2xl)!important}.\!w-40{width:10rem!important}.\!w-fit{width:-moz-fit-content!important;width:fit-content!important}.\!w-full{width:100%!important}.w-1{width:.25rem}.w-1\.5{width:.375rem}.w-1\/2{width:50%}.w-1\/4{width:25%}.w-1\/5{width:20%}.w-10{width:2.5rem}.w-12{width:3rem}.w-14{width:3.5rem}.w-16{width:4rem}.w-2{width:.5rem}.w-20{width:5rem}.w-28{width:7rem}.w-3{width:.75rem}.w-3\/5{width:60%}.w-32{width:8rem}.w-36{width:9rem}.w-4{width:1rem}.w-4\/5{width:80%}.w-40{width:10rem}.w-4xl{width:3.5rem;width:var(--spacing-4xl)}.w-5{width:1.25rem}.w-6{width:1.5rem}.w-60{width:15rem}.w-7{width:1.75rem}.w-8{width:2rem}.w-80{width:20rem}.w-9{width:2.25rem}.w-96{width:24rem}.w-\[\.25rem\]{width:.25rem}.w-\[1\.15em\]{width:1.15em}.w-\[1\.4rem\]{width:1.4rem}.w-\[1\.5rem\]{width:1.5rem}.w-\[1\.6rem\]{width:1.6rem}.w-\[10\%\]{width:10%}.w-\[10\.25rem\]{width:10.25rem}.w-\[10\.625rem\]{width:10.625rem}.w-\[100\%\]{width:100%}.w-\[10rem\]{width:10rem}.w-\[13\.125rem\]{width:13.125rem}.w-\[13rem\]{width:13rem}.w-\[15\%\]{width:15%}.w-\[18rem\]{width:18rem}.w-\[1rem\]{width:1rem}.w-\[2\.5rem\]{width:2.5rem}.w-\[2\.75rem\]{width:2.75rem}.w-\[20\%\]{width:20%}.w-\[22px\]{width:22px}.w-\[25rem\]{width:25rem}.w-\[30\%\]{width:30%}.w-\[33\%\]{width:33%}.w-\[4\.5rem\]{width:4.5rem}.w-\[6\.5rem\]{width:6.5rem}.w-\[6\.75rem\]{width:6.75rem}.w-\[7\.5rem\]{width:7.5rem}.w-\[92\.5vw\]{width:92.5vw}.w-auto{width:auto}.w-fit{width:-moz-fit-content;width:fit-content}.w-full{width:100%}.w-max{width:-moz-max-content;width:max-content}.w-min{width:-moz-min-content;width:min-content}.w-px{width:1px}.w-screen{width:100vw}.\!min-w-0{min-width:0!important}.min-w-10{min-width:2.5rem}.min-w-12{min-width:3rem}.min-w-14{min-width:3.5rem}.min-w-28{min-width:7rem}.min-w-5{min-width:1.25rem}.min-w-6{min-width:1.5rem}.min-w-7{min-width:1.75rem}.min-w-8{min-width:2rem}.min-w-\[0\.5rem\]{min-width:.5rem}.min-w-\[0\.9rem\]{min-width:.9rem}.min-w-\[1\.3rem\]{min-width:1.3rem}.min-w-\[12\.5rem\]{min-width:12.5rem}.min-w-\[146px\]{min-width:146px}.min-w-\[156px\]{min-width:156px}.min-w-\[21rem\]{min-width:21rem}.min-w-\[3\.75rem\]{min-width:3.75rem}.min-w-\[4\.5rem\]{min-width:4.5rem}.min-w-\[6\.5rem\]{min-width:6.5rem}.min-w-fit{min-width:-moz-fit-content;min-width:fit-content}.max-w-\[100\%\]{max-width:100%}.max-w-\[20rem\]{max-width:20rem}.max-w-\[25rem\]{max-width:25rem}.max-w-\[28\.5rem\]{max-width:28.5rem}.max-w-\[30\%\]{max-width:30%}.max-w-\[5rem\]{max-width:5rem}.max-w-\[6px\]{max-width:6px}.max-w-\[80\%\]{max-width:80%}.max-w-\[90rem\]{max-width:90rem}.max-w-\[96\%\]{max-width:96%}.max-w-\[98vw\]{max-width:98vw}.max-w-full{max-width:100%}.max-w-prose{max-width:65ch}.max-w-sm{max-width:24rem}.max-w-xs{max-width:20rem}.\!flex-none{flex:none!important}.flex-1{flex:1 1 0%}.flex-\[1\]{flex:1}.flex-\[2\]{flex:2}.flex-\[3\]{flex:3}.flex-auto{flex:1 1 auto}.flex-none{flex:none}.flex-shrink-0,.shrink-0{flex-shrink:0}.shrink-\[14\]{flex-shrink:14}.grow{flex-grow:1}.grow-\[2\]{flex-grow:2}.basis-6{flex-basis:1.5rem}.origin-bottom{transform-origin:bottom}.origin-bottom-left{transform-origin:bottom left}.origin-bottom-right{transform-origin:bottom right}.origin-center{transform-origin:center}.origin-left{transform-origin:left}.origin-right{transform-origin:right}.origin-top{transform-origin:top}.origin-top-left{transform-origin:top left}.origin-top-right{transform-origin:top right}.-translate-x-1\/2{--tw-translate-x:-50%;transform:translate(-50%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-x-full{--tw-translate-x:-100%;transform:translate(-100%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-1\/2{--tw-translate-y:-50%;transform:translate(var(--tw-translate-x),-50%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-2{--tw-translate-y:-0.5rem;transform:translate(var(--tw-translate-x),-.5rem) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-4{--tw-translate-y:-1rem;transform:translate(var(--tw-translate-x),-1rem) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-\[calc$100\%\+0\.25rem$\]{--tw-translate-y:calc(-100% + -0.25rem);transform:translate(var(--tw-translate-x),calc(-100% + -.25rem)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.-translate-y-full{--tw-translate-y:-100%;transform:translate(var(--tw-translate-x),-100%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-0{--tw-translate-x:0px;transform:translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-0\.5{--tw-translate-x:0.125rem;transform:translate(.125rem,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-\[1\.375rem\]{--tw-translate-x:1.375rem;transform:translate(1.375rem,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-full{--tw-translate-x:100%;transform:translate(100%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-y-0{--tw-translate-y:0px;transform:translate(var(--tw-translate-x)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-y-4{--tw-translate-y:1rem;transform:translate(var(--tw-translate-x),1rem) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-y-full{--tw-translate-y:100%;transform:translate(var(--tw-translate-x),100%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.rotate-180{--tw-rotate:180deg;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(180deg) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.rotate-45{--tw-rotate:45deg;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(45deg) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.scale-100{--tw-scale-x:1;--tw-scale-y:1;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(1) scaleY(1);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.scale-95{--tw-scale-x:.95;--tw-scale-y:.95;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(.95) scaleY(.95);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.scale-\[101\.5\%\]{--tw-scale-x:101.5%;--tw-scale-y:101.5%;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(101.5%) scaleY(101.5%)}.scale-\[101\.5\%\],.transform{transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}@keyframes spin{to{transform:rotate(1turn)}}.animate-spin{animation:spin 1s linear infinite}.cursor-default{cursor:default}.cursor-move{cursor:move}.cursor-not-allowed{cursor:not-allowed}.cursor-pointer{cursor:pointer}.select-none{-webkit-user-select:none;-moz-user-select:none;user-select:none}.resize-none{resize:none}.resize{resize:both}.\!list-inside{list-style-position:inside!important}.list-inside{list-style-position:inside}.list-decimal{list-style-type:decimal}.list-disc{list-style-type:disc}.appearance-none{-webkit-appearance:none;-moz-appearance:none;appearance:none}.grid-cols-3{grid-template-columns:repeat(3,minmax(0,1fr))}.flex-row{flex-direction:row}.flex-row-reverse{flex-direction:row-reverse}.flex-col{flex-direction:column}.flex-col-reverse{flex-direction:column-reverse}.flex-wrap{flex-wrap:wrap}.place-content-center{place-content:center}.content-center{align-content:center}.items-start{align-items:flex-start}.items-end{align-items:flex-end}.items-center{align-items:center}.items-baseline{align-items:baseline}.\!justify-start{justify-content:flex-start!important}.justify-start{justify-content:flex-start}.justify-end{justify-content:flex-end}.justify-center{justify-content:center}.\!justify-between{justify-content:space-between!important}.justify-between{justify-content:space-between}.justify-around{justify-content:space-around}.\!gap-md{gap:1rem!important;gap:var(--spacing-md)!important}.gap-1{gap:.25rem}.gap-2{gap:.5rem}.gap-2\.5{gap:.625rem}.gap-3{gap:.75rem}.gap-4{gap:1rem}.gap-5{gap:1.25rem}.gap-6{gap:1.5rem}.gap-8{gap:2rem}.gap-\[0\.65em\]{gap:.65em}.gap-lg{gap:1.5rem;gap:var(--spacing-lg)}.gap-md{gap:1rem;gap:var(--spacing-md)}.gap-sm{gap:.5rem;gap:var(--spacing-sm)}.gap-xl{gap:2rem;gap:var(--spacing-xl)}.gap-xs{gap:.25rem;gap:var(--spacing-xs)}.gap-x-1{-moz-column-gap:.25rem;column-gap:.25rem}.gap-x-4{-moz-column-gap:1rem;column-gap:1rem}.gap-x-lg{-moz-column-gap:1.5rem;column-gap:1.5rem;-moz-column-gap:var(--spacing-lg);column-gap:var(--spacing-lg)}.gap-x-sm{-moz-column-gap:.5rem;column-gap:.5rem;-moz-column-gap:var(--spacing-sm);column-gap:var(--spacing-sm)}.gap-x-xs{-moz-column-gap:.25rem;column-gap:.25rem;-moz-column-gap:var(--spacing-xs);column-gap:var(--spacing-xs)}.gap-y-5{row-gap:1.25rem}.gap-y-lg{row-gap:1.5rem;row-gap:var(--spacing-lg)}.gap-y-md{row-gap:1rem;row-gap:var(--spacing-md)}.gap-y-sm{row-gap:.5rem;row-gap:var(--spacing-sm)}.gap-y-xl{row-gap:2rem;row-gap:var(--spacing-xl)}.gap-y-xs{row-gap:.25rem;row-gap:var(--spacing-xs)}.space-x-1>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:.25rem;margin-left:calc(.25rem*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(.25rem*var(--tw-space-x-reverse))}.space-x-5>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:1.25rem;margin-left:calc(1.25rem*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(1.25rem*var(--tw-space-x-reverse))}.space-y-1>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(.25rem*var(--tw-space-y-reverse));margin-top:.25rem;margin-top:calc(.25rem*(1 - var(--tw-space-y-reverse)))}.space-y-2>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(.5rem*var(--tw-space-y-reverse));margin-top:.5rem;margin-top:calc(.5rem*(1 - var(--tw-space-y-reverse)))}.space-y-2xl>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(var(--spacing-2xl)*var(--tw-space-y-reverse));margin-top:2.5rem;margin-top:calc(var(--spacing-2xl)*(1 - var(--tw-space-y-reverse)))}.space-y-4>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(1rem*var(--tw-space-y-reverse));margin-top:1rem;margin-top:calc(1rem*(1 - var(--tw-space-y-reverse)))}.space-y-lg>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(var(--spacing-lg)*var(--tw-space-y-reverse));margin-top:1.5rem;margin-top:calc(var(--spacing-lg)*(1 - var(--tw-space-y-reverse)))}.space-y-md>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(var(--spacing-md)*var(--tw-space-y-reverse));margin-top:1rem;margin-top:calc(var(--spacing-md)*(1 - var(--tw-space-y-reverse)))}.space-y-sm>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(var(--spacing-sm)*var(--tw-space-y-reverse));margin-top:.5rem;margin-top:calc(var(--spacing-sm)*(1 - var(--tw-space-y-reverse)))}.space-y-xs>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(var(--spacing-xs)*var(--tw-space-y-reverse));margin-top:.25rem;margin-top:calc(var(--spacing-xs)*(1 - var(--tw-space-y-reverse)))}.divide-y>:not([hidden])~:not([hidden]){--tw-divide-y-reverse:0;border-bottom-width:0;border-bottom-width:calc(1px*var(--tw-divide-y-reverse));border-top-width:1px;border-top-width:calc(1px*(1 - var(--tw-divide-y-reverse)))}.divide-color-default>:not([hidden])~:not([hidden]){--tw-divide-opacity:1;border-color:#dcdfe4;border-color:rgba(var(--color-border-default),var(--tw-divide-opacity))}.self-center{align-self:center}.overflow-auto{overflow:auto}.\!overflow-hidden{overflow:hidden!important}.overflow-hidden{overflow:hidden}.\!overflow-visible{overflow:visible!important}.overflow-scroll{overflow:scroll}.overflow-x-auto{overflow-x:auto}.overflow-y-auto{overflow-y:auto}.overflow-y-hidden{overflow-y:hidden}.overflow-y-scroll{overflow-y:scroll}.overscroll-none{overscroll-behavior:none}.truncate{overflow:hidden;white-space:nowrap}.text-ellipsis,.truncate{text-overflow:ellipsis}.whitespace-nowrap{white-space:nowrap}.whitespace-pre{white-space:pre}.whitespace-pre-line{white-space:pre-line}.\!break-words{overflow-wrap:break-word!important}.break-words{overflow-wrap:break-word}.\!break-all{word-break:break-all!important}.break-all{word-break:break-all}.rounded{border-radius:.25rem}.rounded-2xl{border-radius:1rem}.rounded-3xl{border-radius:1.5rem}.rounded-\[0\.15em\]{border-radius:.15em}.rounded-\[100\%\]{border-radius:100%}.rounded-\[4px\]{border-radius:4px}.rounded-\[50\%\]{border-radius:50%}.rounded-full{border-radius:9999px}.rounded-lg{border-radius:.5rem}.rounded-md{border-radius:.375rem}.rounded-none{border-radius:0}.rounded-sm{border-radius:.125rem}.rounded-xl{border-radius:.75rem}.border{border-width:1px}.border-2{border-width:2px}.border-\[\.0625rem\]{border-width:.0625rem}.border-\[0\.15em\]{border-width:.15em}.border-x-0{border-left-width:0;border-right-width:0}.border-b{border-bottom-width:1px}.border-b-2{border-bottom-width:2px}.border-l{border-left-width:1px}.border-l-2{border-left-width:2px}.border-l-\[0\.0625rem\]{border-left-width:.0625rem}.border-l-\[0\.125rem\]{border-left-width:.125rem}.border-l-\[3px\]{border-left-width:3px}.border-r{border-right-width:1px}.border-t{border-top-width:1px}.border-t-0{border-top-width:0}.border-t-2{border-top-width:2px}.border-t-\[\.0625rem\]{border-top-width:.0625rem}.border-solid{border-style:solid}.border-dashed{border-style:dashed}.border-none{border-style:none}.\!border-color-bold{--tw-border-opacity:1!important;border-color:#b3b9c4!important;border-color:rgba(var(--color-border-bold),var(--tw-border-opacity))!important}.\!border-color-brand{--tw-border-opacity:1!important;border-color:#eab308!important;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity))!important}.border-\[\#000\]{--tw-border-opacity:1;border-color:#000;border-color:rgb(0 0 0/var(--tw-border-opacity))}.border-\[\#DCDFE4\]{--tw-border-opacity:1;border-color:#dcdfe4;border-color:rgb(220 223 228/var(--tw-border-opacity))}.border-\[\#F8F9FD\]{--tw-border-opacity:1;border-color:#f8f9fd;border-color:rgb(248 249 253/var(--tw-border-opacity))}.border-\[\#FACC15\]{--tw-border-opacity:1;border-color:#facc15;border-color:rgb(250 204 21/var(--tw-border-opacity))}.border-\[\#FEF9C3\]{--tw-border-opacity:1;border-color:#fef9c3;border-color:rgb(254 249 195/var(--tw-border-opacity))}.border-\[\#b3b9c4\]{--tw-border-opacity:1;border-color:#b3b9c4;border-color:rgb(179 185 196/var(--tw-border-opacity))}.border-\[\#dcdfe6\]{--tw-border-opacity:1;border-color:#dcdfe6;border-color:rgb(220 223 230/var(--tw-border-opacity))}.border-\[\#f8f9fd\]{--tw-border-opacity:1;border-color:#f8f9fd;border-color:rgb(248 249 253/var(--tw-border-opacity))}.border-\[white\]{--tw-border-opacity:1;border-color:#fff;border-color:rgb(255 255 255/var(--tw-border-opacity))}.border-color-bold{--tw-border-opacity:1;border-color:#b3b9c4;border-color:rgba(var(--color-border-bold),var(--tw-border-opacity))}.border-color-brand{--tw-border-opacity:1;border-color:#eab308;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity))}.border-color-default{--tw-border-opacity:1;border-color:#dcdfe4;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.border-color-error{--tw-border-opacity:1;border-color:#e11900;border-color:rgba(var(--color-border-error),var(--tw-border-opacity))}.border-color-info{--tw-border-opacity:1;border-color:#59baf0;border-color:rgba(var(--color-border-info),var(--tw-border-opacity))}.border-color-inherit{border-color:inherit}.border-color-success{--tw-border-opacity:1;border-color:#05944f;border-color:rgba(var(--color-border-success),var(--tw-border-opacity))}.border-color-transparent{border-color:transparent}.border-color-warning{--tw-border-opacity:1;border-color:#eab308;border-color:rgba(var(--color-border-warning),var(--tw-border-opacity))}.border-t-color-default{--tw-border-opacity:1;border-top-color:#dcdfe4;border-top-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.\!bg-black{--tw-bg-opacity:1!important;background-color:#000!important;background-color:rgba(var(--color-black),var(--tw-bg-opacity))!important}.\!bg-brand-bold{--tw-bg-opacity:1!important;background-color:#eab308!important;background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))!important}.\!bg-brand-default{--tw-bg-opacity:1!important;background-color:#facc15!important;background-color:rgba(var(--color-brand-default),var(--tw-bg-opacity))!important}.\!bg-brand-subtler{--tw-bg-opacity:1!important;background-color:#fef08a!important;background-color:rgba(var(--color-brand-subtler),var(--tw-bg-opacity))!important}.\!bg-brand-sunken{--tw-bg-opacity:1!important;background-color:#fefce8!important;background-color:rgba(var(--color-brand-sunken),var(--tw-bg-opacity))!important}.\!bg-success-subtlest{--tw-bg-opacity:1!important;background-color:#bfeed7!important;background-color:rgba(var(--color-bg-success-subtlest),var(--tw-bg-opacity))!important}.\!bg-surface-disabled{--tw-bg-opacity:1!important;background-color:#f1f2f4!important;background-color:rgba(var(--color-surface-disabled),var(--tw-bg-opacity))!important}.\!bg-surface-subtle{--tw-bg-opacity:1!important;background-color:#f8f9fd!important;background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))!important}.\!bg-warning-bold{--tw-bg-opacity:1!important;background-color:#eab308!important;background-color:rgba(var(--color-bg-warning-bold),var(--tw-bg-opacity))!important}.bg-\[\#000000\],.bg-\[\#000\]{--tw-bg-opacity:1;background-color:#000;background-color:rgb(0 0 0/var(--tw-bg-opacity))}.bg-\[\#2867B2\]{--tw-bg-opacity:1;background-color:#2867b2;background-color:rgb(40 103 178/var(--tw-bg-opacity))}.bg-\[\#409eff\]{--tw-bg-opacity:1;background-color:#409eff;background-color:rgb(64 158 255/var(--tw-bg-opacity))}.bg-\[\#66b1ff\]{--tw-bg-opacity:1;background-color:#66b1ff;background-color:rgb(102 177 255/var(--tw-bg-opacity))}.bg-\[\#EAB308\]{--tw-bg-opacity:1;background-color:#eab308;background-color:rgb(234 179 8/var(--tw-bg-opacity))}.bg-\[\#F8F9FD\]{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgb(248 249 253/var(--tw-bg-opacity))}.bg-\[\#b3b9c4\]{--tw-bg-opacity:1;background-color:#b3b9c4;background-color:rgb(179 185 196/var(--tw-bg-opacity))}.bg-\[\#eaeaee\]{--tw-bg-opacity:1;background-color:#eaeaee;background-color:rgb(234 234 238/var(--tw-bg-opacity))}.bg-\[\#facc15\]{--tw-bg-opacity:1;background-color:#facc15;background-color:rgb(250 204 21/var(--tw-bg-opacity))}.bg-\[\#fff\]{--tw-bg-opacity:1;background-color:#fff;background-color:rgb(255 255 255/var(--tw-bg-opacity))}.bg-black{--tw-bg-opacity:1;background-color:#000;background-color:rgba(var(--color-black),var(--tw-bg-opacity))}.bg-black\/50{background-color:rgba(0,0,0,.5);background-color:rgba(var(--color-black),.5)}.bg-black\/60{background-color:rgba(0,0,0,.6);background-color:rgba(var(--color-black),.6)}.bg-black\/\[0\.12\]{background-color:rgba(0,0,0,.12);background-color:rgba(var(--color-black),.12)}.bg-brand-bold{--tw-bg-opacity:1;background-color:#eab308;background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.bg-brand-boldest{--tw-bg-opacity:1;background-color:#c48404;background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.bg-brand-default{--tw-bg-opacity:1;background-color:#facc15;background-color:rgba(var(--color-brand-default),var(--tw-bg-opacity))}.bg-brand-subtler{--tw-bg-opacity:1;background-color:#fef08a;background-color:rgba(var(--color-brand-subtler),var(--tw-bg-opacity))}.bg-brand-subtlest{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.bg-brand-sunken{--tw-bg-opacity:1;background-color:#fefce8;background-color:rgba(var(--color-brand-sunken),var(--tw-bg-opacity))}.bg-content-bolder{--tw-bg-opacity:1;background-color:#d19507;background-color:rgba(var(--color-bg-content-bolder),var(--tw-bg-opacity))}.bg-content-default{--tw-bg-opacity:1;background-color:#facc15;background-color:rgba(var(--color-bg-content-default),var(--tw-bg-opacity))}.bg-content-inverse-subtler{--tw-bg-opacity:1;background-color:#a86a07;background-color:rgba(var(--color-bg-content-inverse-subtler),var(--tw-bg-opacity))}.bg-content-subtle{--tw-bg-opacity:1;background-color:#fde047;background-color:rgba(var(--color-bg-content-subtle),var(--tw-bg-opacity))}.bg-content-subtler{--tw-bg-opacity:1;background-color:#fef08a;background-color:rgba(var(--color-bg-content-subtler),var(--tw-bg-opacity))}.bg-content-subtlest{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-bg-content-subtlest),var(--tw-bg-opacity))}.bg-content-sunken{--tw-bg-opacity:1;background-color:#fefce8;background-color:rgba(var(--color-bg-content-sunken),var(--tw-bg-opacity))}.bg-error-bold{--tw-bg-opacity:1;background-color:#e11900;background-color:rgba(var(--color-bg-error-bold),var(--tw-bg-opacity))}.bg-error-subtlest{--tw-bg-opacity:1;background-color:#ffdad4;background-color:rgba(var(--color-bg-error-subtlest),var(--tw-bg-opacity))}.bg-error-sunken{--tw-bg-opacity:1;background-color:#fffbff;background-color:rgba(var(--color-bg-error-sunken),var(--tw-bg-opacity))}.bg-info-bold{--tw-bg-opacity:1;background-color:#59baf0;background-color:rgba(var(--color-bg-info-bold),var(--tw-bg-opacity))}.bg-info-subtlest{--tw-bg-opacity:1;background-color:#dcf3ff;background-color:rgba(var(--color-bg-info-subtlest),var(--tw-bg-opacity))}.bg-info-sunken{--tw-bg-opacity:1;background-color:#f5fbff;background-color:rgba(var(--color-bg-info-sunken),var(--tw-bg-opacity))}.bg-inherit{background-color:inherit}.bg-success-bold{--tw-bg-opacity:1;background-color:#05944f;background-color:rgba(var(--color-bg-success-bold),var(--tw-bg-opacity))}.bg-success-subtlest{--tw-bg-opacity:1;background-color:#bfeed7;background-color:rgba(var(--color-bg-success-subtlest),var(--tw-bg-opacity))}.bg-success-sunken{--tw-bg-opacity:1;background-color:#f1fef8;background-color:rgba(var(--color-bg-success-sunken),var(--tw-bg-opacity))}.bg-surface-default{--tw-bg-opacity:1;background-color:#fff;background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.bg-surface-disabled{--tw-bg-opacity:1;background-color:#f1f2f4;background-color:rgba(var(--color-surface-disabled),var(--tw-bg-opacity))}.bg-surface-inverse{--tw-bg-opacity:1;background-color:#000;background-color:rgba(var(--color-surface-inverse),var(--tw-bg-opacity))}.bg-surface-selected{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))}.bg-surface-subtle{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.bg-transparent{background-color:transparent}.bg-warning-bold{--tw-bg-opacity:1;background-color:#eab308;background-color:rgba(var(--color-bg-warning-bold),var(--tw-bg-opacity))}.bg-warning-subtlest{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-bg-warning-subtlest),var(--tw-bg-opacity))}.bg-warning-sunken{--tw-bg-opacity:1;background-color:#fefce8;background-color:rgba(var(--color-bg-warning-sunken),var(--tw-bg-opacity))}.bg-white{--tw-bg-opacity:1;background-color:#fff;background-color:rgba(var(--color-white),var(--tw-bg-opacity))}.bg-opacity-25{--tw-bg-opacity:0.25}.bg-opacity-75{--tw-bg-opacity:0.75}.bg-\[url$\'\/img\/homepage\.png\'$\]{background-image:url(/img/homepage.png)}.bg-gradient-to-r{background-image:linear-gradient(to right,var(--tw-gradient-stops))}.bg-none{background-image:none}.from-black\/70{--tw-gradient-from:rgba(var(--color-black),0.7) var(--tw-gradient-from-position);--tw-gradient-to:rgba(var(--color-black),0) var(--tw-gradient-to-position);--tw-gradient-stops:var(--tw-gradient-from),var(--tw-gradient-to)}.from-transparent{--tw-gradient-from:transparent var(--tw-gradient-from-position);--tw-gradient-to:transparent var(--tw-gradient-to-position);--tw-gradient-stops:var(--tw-gradient-from),var(--tw-gradient-to)}.to-black\/5{--tw-gradient-to:rgba(var(--color-black),0.05) var(--tw-gradient-to-position)}.to-white{--tw-gradient-to:rgba(var(--color-white),1) var(--tw-gradient-to-position)}.bg-cover{background-size:cover}.bg-fixed{background-attachment:fixed}.bg-center{background-position:50%}.bg-no-repeat{background-repeat:no-repeat}.fill-brand-bold{fill:#eab308;fill:rgba(var(--color-brand-bold),1)}.fill-brand-sunken{fill:#fefce8;fill:rgba(var(--color-brand-sunken),1)}.object-cover{-o-object-fit:cover;object-fit:cover}.\!p-0{padding:0!important}.\!p-sm{padding:.5rem!important;padding:var(--spacing-sm)!important}.\!p-xs{padding:.25rem!important;padding:var(--spacing-xs)!important}.p-0{padding:0}.p-0\.5{padding:.125rem}.p-4{padding:1rem}.p-5{padding:1.25rem}.p-8{padding:2rem}.p-\[\.75rem\]{padding:.75rem}.p-lg{padding:1.5rem;padding:var(--spacing-lg)}.p-md{padding:1rem;padding:var(--spacing-md)}.p-px{padding:1px}.p-sm{padding:.5rem;padding:var(--spacing-sm)}.p-xl{padding:2rem;padding:var(--spacing-xl)}.\!px-0{padding-left:0!important;padding-right:0!important}.\!px-sm{padding-left:.5rem!important;padding-left:var(--spacing-sm)!important;padding-right:.5rem!important;padding-right:var(--spacing-sm)!important}.px-0{padding-left:0;padding-right:0}.px-10{padding-left:2.5rem;padding-right:2.5rem}.px-2{padding-left:.5rem;padding-right:.5rem}.px-4{padding-left:1rem;padding-right:1rem}.px-5{padding-left:1.25rem;padding-right:1.25rem}.px-8{padding-left:2rem;padding-right:2rem}.px-\[\.625rem\]{padding-left:.625rem;padding-right:.625rem}.px-\[\.9375rem\]{padding-left:.9375rem;padding-right:.9375rem}.px-\[0\.2rem\]{padding-left:.2rem;padding-right:.2rem}.px-\[0\.625rem\]{padding-left:.625rem;padding-right:.625rem}.px-lg{padding-left:1.5rem;padding-left:var(--spacing-lg);padding-right:1.5rem;padding-right:var(--spacing-lg)}.px-md{padding-left:1rem;padding-left:var(--spacing-md);padding-right:1rem;padding-right:var(--spacing-md)}.px-sm{padding-left:.5rem;padding-left:var(--spacing-sm);padding-right:.5rem;padding-right:var(--spacing-sm)}.px-xl{padding-left:2rem;padding-left:var(--spacing-xl);padding-right:2rem;padding-right:var(--spacing-xl)}.px-xs{padding-left:.25rem;padding-left:var(--spacing-xs);padding-right:.25rem;padding-right:var(--spacing-xs)}.py-0{padding-bottom:0;padding-top:0}.py-0\.5{padding-bottom:.125rem;padding-top:.125rem}.py-10{padding-bottom:2.5rem;padding-top:2.5rem}.py-2{padding-bottom:.5rem;padding-top:.5rem}.py-2xl{padding-bottom:2.5rem;padding-bottom:var(--spacing-2xl);padding-top:2.5rem;padding-top:var(--spacing-2xl)}.py-3{padding-bottom:.75rem;padding-top:.75rem}.py-3xl{padding-bottom:3rem;padding-bottom:var(--spacing-3xl);padding-top:3rem;padding-top:var(--spacing-3xl)}.py-4{padding-bottom:1rem;padding-top:1rem}.py-5xl{padding-bottom:4rem;padding-bottom:var(--spacing-5xl);padding-top:4rem;padding-top:var(--spacing-5xl)}.py-6{padding-bottom:1.5rem;padding-top:1.5rem}.py-7xl{padding-bottom:5rem;padding-bottom:var(--spacing-7xl);padding-top:5rem;padding-top:var(--spacing-7xl)}.py-\[\.3125rem\]{padding-bottom:.3125rem;padding-top:.3125rem}.py-\[0\.625rem\],.py-\[\.625rem\]{padding-bottom:.625rem;padding-top:.625rem}.py-\[1\.5rem\],.py-lg{padding-bottom:1.5rem;padding-top:1.5rem}.py-lg{padding-bottom:var(--spacing-lg);padding-top:var(--spacing-lg)}.py-md{padding-bottom:1rem;padding-bottom:var(--spacing-md);padding-top:1rem;padding-top:var(--spacing-md)}.py-sm{padding-bottom:.5rem;padding-bottom:var(--spacing-sm);padding-top:.5rem;padding-top:var(--spacing-sm)}.py-xl{padding-bottom:2rem;padding-bottom:var(--spacing-xl);padding-top:2rem;padding-top:var(--spacing-xl)}.py-xs{padding-bottom:.25rem;padding-bottom:var(--spacing-xs);padding-top:.25rem;padding-top:var(--spacing-xs)}.\!pl-0{padding-left:0!important}.\!pl-sm{padding-left:.5rem!important;padding-left:var(--spacing-sm)!important}.\!pr-sm{padding-right:.5rem!important;padding-right:var(--spacing-sm)!important}.pb-0{padding-bottom:0}.pb-2xl{padding-bottom:2.5rem;padding-bottom:var(--spacing-2xl)}.pb-3{padding-bottom:.75rem}.pb-6{padding-bottom:1.5rem}.pb-7xl{padding-bottom:5rem;padding-bottom:var(--spacing-7xl)}.pb-\[\.5rem\]{padding-bottom:.5rem}.pb-\[1\.875rem\]{padding-bottom:1.875rem}.pb-lg{padding-bottom:1.5rem;padding-bottom:var(--spacing-lg)}.pb-md{padding-bottom:1rem;padding-bottom:var(--spacing-md)}.pb-sm{padding-bottom:.5rem;padding-bottom:var(--spacing-sm)}.pb-xl{padding-bottom:2rem;padding-bottom:var(--spacing-xl)}.pb-xs{padding-bottom:.25rem;padding-bottom:var(--spacing-xs)}.pl-0{padding-left:0}.pl-10,.pl-2xl{padding-left:2.5rem}.pl-2xl{padding-left:var(--spacing-2xl)}.pl-3{padding-left:.75rem}.pl-5{padding-left:1.25rem}.pl-8{padding-left:2rem}.pl-lg{padding-left:1.5rem;padding-left:var(--spacing-lg)}.pl-md{padding-left:1rem;padding-left:var(--spacing-md)}.pl-sm{padding-left:.5rem;padding-left:var(--spacing-sm)}.pl-xl{padding-left:2rem;padding-left:var(--spacing-xl)}.pl-xs{padding-left:.25rem;padding-left:var(--spacing-xs)}.pr-0{padding-right:0}.pr-2xl{padding-right:2.5rem;padding-right:var(--spacing-2xl)}.pr-3{padding-right:.75rem}.pr-lg{padding-right:1.5rem;padding-right:var(--spacing-lg)}.pr-md{padding-right:1rem;padding-right:var(--spacing-md)}.pr-sm{padding-right:.5rem;padding-right:var(--spacing-sm)}.pr-xl{padding-right:2rem;padding-right:var(--spacing-xl)}.pr-xs{padding-right:.25rem;padding-right:var(--spacing-xs)}.pt-12{padding-top:3rem}.pt-14{padding-top:3.5rem}.pt-2xl{padding-top:2.5rem;padding-top:var(--spacing-2xl)}.pt-3xl{padding-top:3rem;padding-top:var(--spacing-3xl)}.pt-5xl{padding-top:4rem;padding-top:var(--spacing-5xl)}.pt-6{padding-top:1.5rem}.pt-7xl{padding-top:5rem;padding-top:var(--spacing-7xl)}.pt-\[\.625rem\]{padding-top:.625rem}.pt-\[\.75rem\]{padding-top:.75rem}.pt-\[0\.125rem\]{padding-top:.125rem}.pt-\[1\.25rem\]{padding-top:1.25rem}.pt-\[1\.875rem\]{padding-top:1.875rem}.pt-\[1rem\]{padding-top:1rem}.pt-\[2rem\]{padding-top:2rem}.pt-\[5rem\]{padding-top:5rem}.pt-lg{padding-top:1.5rem;padding-top:var(--spacing-lg)}.pt-md{padding-top:1rem;padding-top:var(--spacing-md)}.pt-sm{padding-top:.5rem;padding-top:var(--spacing-sm)}.pt-xl{padding-top:2rem;padding-top:var(--spacing-xl)}.pt-xs{padding-top:.25rem;padding-top:var(--spacing-xs)}.text-left{text-align:left}.text-center{text-align:center}.text-right{text-align:right}.\!align-middle{vertical-align:middle!important}.align-middle{vertical-align:middle}.\!align-text-bottom{vertical-align:text-bottom!important}.\!text-base{font-size:1rem!important;line-height:1.5rem!important}.\!text-lg{font-size:1.125rem!important;line-height:1.75rem!important}.\!text-xs{font-size:.75rem!important;line-height:1rem!important}.text-2xl{font-size:1.5rem;line-height:2rem}.text-3xl{font-size:1.875rem;line-height:2.25rem}.text-4xl{font-size:2.25rem;line-height:2.5rem}.text-5xl{font-size:3rem;line-height:1}.text-\[\.4rem\]{font-size:.4rem}.text-\[\.75rem\]{font-size:.75rem}.text-\[\.875rem\]{font-size:.875rem}.text-\[0\.4rem\]{font-size:.4rem}.text-\[0\.575rem\]{font-size:.575rem}.text-\[1\.875rem\]{font-size:1.875rem}.text-\[2\.5rem\]{font-size:2.5rem}.text-base{font-size:1rem;line-height:1.5rem}.text-lg{font-size:1.125rem;line-height:1.75rem}.text-sm{font-size:.875rem;line-height:1.25rem}.text-xl{font-size:1.25rem;line-height:1.75rem}.text-xs{font-size:.75rem;line-height:1rem}.font-bold{font-weight:700}.font-light{font-weight:300}.font-medium{font-weight:500}.font-normal{font-weight:400}.font-semibold{font-weight:600}.uppercase{text-transform:uppercase}.lowercase{text-transform:lowercase}.italic{font-style:italic}.\!leading-\[0\]{line-height:0!important}.leading-10{line-height:2.5rem}.leading-6{line-height:1.5rem}.leading-\[0\]{line-height:0}.leading-\[1\.125rem\]{line-height:1.125rem}.leading-\[1\.1\]{line-height:1.1}.leading-\[1\.875rem\]{line-height:1.875rem}.leading-\[140\%\]{line-height:140%}.leading-none{line-height:1}.leading-normal{line-height:1.5}.\!text-color-black{--tw-text-opacity:1!important;color:#000!important;color:rgba(var(--color-black),var(--tw-text-opacity))!important}.\!text-color-brand-bold{--tw-text-opacity:1!important;color:#eab308!important;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))!important}.\!text-color-default{--tw-text-opacity:1!important;color:#000!important;color:rgba(var(--color-text-default),var(--tw-text-opacity))!important}.\!text-color-disabled{--tw-text-opacity:1!important;color:#b3b9c4!important;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))!important}.\!text-color-link-bold{--tw-text-opacity:1!important;color:#0156ce!important;color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))!important}.\!text-color-subtle{--tw-text-opacity:1!important;color:#626f86!important;color:rgba(var(--color-text-subtle),var(--tw-text-opacity))!important}.\!text-color-white{--tw-text-opacity:1!important;color:#fff!important;color:rgba(var(--color-white),var(--tw-text-opacity))!important}.text-\[\#000\]{--tw-text-opacity:1;color:#000;color:rgb(0 0 0/var(--tw-text-opacity))}.text-\[\#0156CE\]{--tw-text-opacity:1;color:#0156ce;color:rgb(1 86 206/var(--tw-text-opacity))}.text-\[\#172B4D\]{--tw-text-opacity:1;color:#172b4d;color:rgb(23 43 77/var(--tw-text-opacity))}.text-\[\#626F86\]{--tw-text-opacity:1;color:#626f86;color:rgb(98 111 134/var(--tw-text-opacity))}.text-\[\#758195\]{--tw-text-opacity:1;color:#758195;color:rgb(117 129 149/var(--tw-text-opacity))}.text-\[\#EAB308\]{--tw-text-opacity:1;color:#eab308;color:rgb(234 179 8/var(--tw-text-opacity))}.text-\[\#F1F2F4\]{--tw-text-opacity:1;color:#f1f2f4;color:rgb(241 242 244/var(--tw-text-opacity))}.text-\[\#FACC15\]{--tw-text-opacity:1;color:#facc15;color:rgb(250 204 21/var(--tw-text-opacity))}.text-\[\#FFFFFF\]{--tw-text-opacity:1;color:#fff;color:rgb(255 255 255/var(--tw-text-opacity))}.text-\[\#b3b9c4\]{--tw-text-opacity:1;color:#b3b9c4;color:rgb(179 185 196/var(--tw-text-opacity))}.text-\[\#f00\]{--tw-text-opacity:1;color:red;color:rgb(255 0 0/var(--tw-text-opacity))}.text-\[\#fff\]{--tw-text-opacity:1;color:#fff;color:rgb(255 255 255/var(--tw-text-opacity))}.text-color-black{--tw-text-opacity:1;color:#000;color:rgba(var(--color-black),var(--tw-text-opacity))}.text-color-border-bold{--tw-text-opacity:1;color:#b3b9c4;color:rgba(var(--color-border-bold),var(--tw-text-opacity))}.text-color-brand-bold{--tw-text-opacity:1;color:#eab308;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.text-color-brand-bolder{--tw-text-opacity:1;color:#d19507;color:rgba(var(--color-text-brand-bolder),var(--tw-text-opacity))}.text-color-current{color:currentColor}.text-color-default{--tw-text-opacity:1;color:#000;color:rgba(var(--color-text-default),var(--tw-text-opacity))}.text-color-disabled{--tw-text-opacity:1;color:#b3b9c4;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.text-color-error{--tw-text-opacity:1;color:#d31c04;color:rgba(var(--color-text-error),var(--tw-text-opacity))}.text-color-info{--tw-text-opacity:1;color:#2c9acf;color:rgba(var(--color-text-info),var(--tw-text-opacity))}.text-color-inherit{color:inherit}.text-color-inverse{--tw-text-opacity:1;color:#fff;color:rgba(var(--color-white),var(--tw-text-opacity))}.text-color-link-bold{--tw-text-opacity:1;color:#0156ce;color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.text-color-link-bolder{--tw-text-opacity:1;color:#014bb5;color:rgba(var(--color-text-link-bolder),var(--tw-text-opacity))}.text-color-link-subtle{--tw-text-opacity:1;color:#626f86;color:rgba(var(--color-text-link-subtle),var(--tw-text-opacity))}.text-color-on-brand{--tw-text-opacity:1;color:rgba(var(--color-text-on-brand),1);color:rgba(var(--color-text-on-brand),var(--tw-text-opacity))}.text-color-subtle{--tw-text-opacity:1;color:#626f86;color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.text-color-subtlest{--tw-text-opacity:1;color:#758195;color:rgba(var(--color-text-subtlest),var(--tw-text-opacity))}.text-color-success{--tw-text-opacity:1;color:#098549;color:rgba(var(--color-text-success),var(--tw-text-opacity))}.text-color-warning{--tw-text-opacity:1;color:#d19507;color:rgba(var(--color-text-warning),var(--tw-text-opacity))}.text-color-white{--tw-text-opacity:1;color:#fff;color:rgba(var(--color-white),var(--tw-text-opacity))}.underline{text-decoration-line:underline}.\!no-underline{text-decoration-line:none!important}.no-underline{text-decoration-line:none}.antialiased{-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}.placeholder-text-color-subtle::-moz-placeholder{--tw-placeholder-opacity:1;color:#626f86;color:rgba(var(--color-text-subtle),var(--tw-placeholder-opacity))}.placeholder-text-color-subtle::placeholder{--tw-placeholder-opacity:1;color:#626f86;color:rgba(var(--color-text-subtle),var(--tw-placeholder-opacity))}.opacity-0{opacity:0}.opacity-100{opacity:1}.opacity-25{opacity:.25}.opacity-40{opacity:.4}.shadow{--tw-shadow:0 1px 3px 0 rgba(0,0,0,.1),0 1px 2px -1px rgba(0,0,0,.1);--tw-shadow-colored:0 1px 3px 0 var(--tw-shadow-color),0 1px 2px -1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 1px 3px 0 rgba(0,0,0,.1),0 1px 2px -1px rgba(0,0,0,.1);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-\[4px_8px_10px_rgba$214\2c 217\2c 222\2c 0\.8$\]{--tw-shadow:4px 8px 10px rgba(214,217,222,.8);--tw-shadow-colored:4px 8px 10px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,4px 8px 10px rgba(214,217,222,.8);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-lg{--tw-shadow:0 10px 15px -3px rgba(0,0,0,.1),0 4px 6px -4px rgba(0,0,0,.1);--tw-shadow-colored:0 10px 15px -3px var(--tw-shadow-color),0 4px 6px -4px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 10px 15px -3px rgba(0,0,0,.1),0 4px 6px -4px rgba(0,0,0,.1);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-md{--tw-shadow:0 4px 6px -1px rgba(0,0,0,.1),0 2px 4px -2px rgba(0,0,0,.1);--tw-shadow-colored:0 4px 6px -1px var(--tw-shadow-color),0 2px 4px -2px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 4px 6px -1px rgba(0,0,0,.1),0 2px 4px -2px rgba(0,0,0,.1);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-slider{--tw-shadow:0.5px 0.5px 2px 1px rgba(0,0,0,.32);--tw-shadow-colored:0.5px 0.5px 2px 1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,.5px .5px 2px 1px rgba(0,0,0,.32);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-slider-active{--tw-shadow:0.5px 0.5px 2px 1px rgba(0,0,0,.42);--tw-shadow-colored:0.5px 0.5px 2px 1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,.5px .5px 2px 1px rgba(0,0,0,.42);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-sm{--tw-shadow:0 1px 2px 0 rgba(0,0,0,.05);--tw-shadow-colored:0 1px 2px 0 var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 1px 2px 0 rgba(0,0,0,.05);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.shadow-xl{--tw-shadow:0 20px 25px -5px rgba(0,0,0,.1),0 8px 10px -6px rgba(0,0,0,.1);--tw-shadow-colored:0 20px 25px -5px var(--tw-shadow-color),0 8px 10px -6px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 20px 25px -5px rgba(0,0,0,.1),0 8px 10px -6px rgba(0,0,0,.1);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.outline-none{outline:2px solid transparent;outline-offset:2px}.outline{outline-style:solid}.outline-2{outline-width:2px}.outline-offset-2{outline-offset:2px}.outline-\[\#EAB308\]{outline-color:#eab308}.outline-color-bold{outline-color:#b3b9c4;outline-color:rgba(var(--color-border-bold),1)}.outline-color-brand{outline-color:#eab308;outline-color:rgba(var(--color-border-brand),1)}.ring-0{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.blur{--tw-blur:blur(8px);filter:blur(8px) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.grayscale{--tw-grayscale:grayscale(100%);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) grayscale(100%) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.filter,.grayscale{filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.transition{transition-duration:.15s;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke,opacity,box-shadow,transform,filter,-webkit-backdrop-filter;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke,opacity,box-shadow,transform,filter,backdrop-filter;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke,opacity,box-shadow,transform,filter,backdrop-filter,-webkit-backdrop-filter;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-all{transition-duration:.15s;transition-property:all;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-colors{transition-duration:.15s;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-height{transition-duration:.15s;transition-property:height;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-opacity{transition-duration:.15s;transition-property:opacity;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-transform{transition-duration:.15s;transition-property:transform;transition-timing-function:cubic-bezier(.4,0,.2,1)}.duration-100{transition-duration:.1s}.duration-150{transition-duration:.15s}.duration-200{transition-duration:.2s}.duration-300{transition-duration:.3s}.duration-75{transition-duration:75ms}.duration-\[350ms\]{transition-duration:.35s}.ease-in{transition-timing-function:cubic-bezier(.4,0,1,1)}.ease-in-out{transition-timing-function:cubic-bezier(.4,0,.2,1)}.ease-out{transition-timing-function:cubic-bezier(0,0,.2,1)}.content-\[\'\'\]{--tw-content:"";content:"";content:var(--tw-content)}.cursor-grab{cursor:grab}.cursor-grabbing{cursor:grabbing}.touch-none{touch-action:none}.tap-highlight-transparent{-webkit-tap-highlight-color:rgba(0,0,0,0)}.touch-callout-none{-webkit-touch-callout:none}.transform-origin-0{transform-origin:0 0}.transform-style-flat{transform-style:flat}.cursor-ew-resize{cursor:ew-resize}.arrow-left:before{border:5px solid transparent;border-right-color:inherit;left:-10px}.arrow-left:before,.arrow-right:before{content:"";height:0;position:absolute;top:50%;transform:translateY(-50%);width:0}.arrow-right:before{border:5px solid transparent;border-left-color:inherit;right:-10px}.text-body{font-size:.875rem;line-height:1.25rem}@media (min-width:768px){.text-body{font-size:1rem;line-height:1.5rem}}.\[appearance\:textfield\]{-webkit-appearance:textfield;-moz-appearance:textfield;appearance:textfield}@media (max-width:64rem){.phone-drawer{z-index:20}.phone-drawer .w-screen{padding:0;width:75vw}.phone-drawer .user-info-nav li{line-height:1.5rem;margin-bottom:.9375rem;padding:.5rem 0 .5rem 2.375rem}.phone-drawer .user-info-nav li:hover{cursor:pointer}.phone-drawer .user-info-nav .active-nav{background-color:#f7f8f9}}.comment-drawer .m-drawer__panel{padding:1rem;padding:var(--spacing-md)}@media (min-width:1024px){.comment-drawer .m-drawer__panel{max-width:none;padding:1.5rem;padding:var(--spacing-lg);width:50.25rem}}.m-checkbox:active,.m-checkbox:target{--tw-text-opacity:1;color:#eab308;color:rgb(234 179 8/var(--tw-text-opacity))}body,html{scroll-behavior:auto!important}.mfp-mask{-webkit-backface-visibility:hidden;background-color:rgba(0,0,0,.85);display:none;outline:0!important;overflow:hidden auto;position:fixed;z-index:99}.mfp-mask,.mfp-mask .mfp-dialog{height:100%;left:0;top:0;width:100%}.mfp-mask .mfp-dialog{box-sizing:border-box;padding:0 8px;position:absolute;text-align:center}.mfp-mask .mfp-dialog .mfp-dialog-content{align-items:center;display:inline-block;display:flex;justify-content:center;margin:0 auto;min-height:100vh;position:relative;text-align:left;vertical-align:middle;z-index:100}.mfp-mask .mfp-dialog .mfp-dialog-content .html-fig_show{background:#fff;max-width:600px;overflow:auto;padding:20px;position:relative;width:auto}.mfp-mask .mfp-dialog .mfp-dialog-content .html-table_show{background:#fff;margin-bottom:40px;margin-top:40px;overflow:auto;padding:20px;position:relative;width:auto}@media (max-width:64rem){.mfp-mask .mfp-dialog .mfp-dialog-content .html-table_show{background:#fff;margin-bottom:40px;margin-top:40px;overflow:auto;padding:20px;position:relative;width:100%}}.mfp-mask .mfp-dialog .mfp-dialog-content .html-table_foot{max-width:650px}.mfp-mask .mfp-close{background:none;border:none;color:#000;cursor:pointer;font-size:16px;overflow:hidden;padding:10px 20px;position:absolute;right:10px;top:10px;z-index:999}.mfp-mask .mfp-close:before{bottom:0;content:"✖";height:20px;left:0;margin:auto;position:absolute;right:0;top:0;width:20px}.heading-with-anchor{scroll-margin-top:4rem}.global-search .m-drawer__panel{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.global-search .m-drawer__body,.global-search .m-drawer__header{margin-left:auto;margin-right:auto;width:90%}.MJX-TEX{font-family:Suisse Int\'l,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji!important}mark{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.before\:absolute:before{content:var(--tw-content);position:absolute}.before\:-inset-2:before{content:var(--tw-content);inset:-.5rem}.after\:absolute:after{content:var(--tw-content);position:absolute}.after\:hidden:after{content:var(--tw-content);display:none}.after\:h-1\/2:after{content:var(--tw-content);height:50%}.after\:w-1\/2:after{content:var(--tw-content);width:50%}.after\:rounded-full:after{border-radius:9999px;content:var(--tw-content)}.after\:bg-brand-bold:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:#eab308;background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.after\:bg-content-default:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:#facc15;background-color:rgba(var(--color-bg-content-default),var(--tw-bg-opacity))}.first\:pt-0:first-child{padding-top:0}.focus-within\:outline-none:focus-within{outline:2px solid transparent;outline-offset:2px}.focus-within\:outline:focus-within{outline-style:solid}.hover\:rounded-2xl:hover{border-radius:1rem}.hover\:border-2:hover{border-width:2px}.hover\:border-\[\#0156CE\]:hover{--tw-border-opacity:1;border-color:#0156ce;border-color:rgb(1 86 206/var(--tw-border-opacity))}.hover\:border-\[\#F8F9FD\]:hover{--tw-border-opacity:1;border-color:#f8f9fd;border-color:rgb(248 249 253/var(--tw-border-opacity))}.hover\:border-color-brand:hover{--tw-border-opacity:1;border-color:#eab308;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity))}.hover\:\!bg-surface-selected:hover{--tw-bg-opacity:1!important;background-color:#f8f9fd!important;background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))!important}.hover\:\!bg-transparent:hover{background-color:transparent!important}.hover\:bg-brand-bolder:hover{--tw-bg-opacity:1;background-color:#d19507;background-color:rgba(var(--color-brand-bolder),var(--tw-bg-opacity))}.hover\:bg-brand-subtlest:hover{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.hover\:bg-brand-sunken:hover{--tw-bg-opacity:1;background-color:#fefce8;background-color:rgba(var(--color-brand-sunken),var(--tw-bg-opacity))}.hover\:bg-content-bold:hover{--tw-bg-opacity:1;background-color:#eab308;background-color:rgba(var(--color-bg-content-bold),var(--tw-bg-opacity))}.hover\:bg-content-sunken:hover{--tw-bg-opacity:1;background-color:#fefce8;background-color:rgba(var(--color-bg-content-sunken),var(--tw-bg-opacity))}.hover\:bg-surface-default:hover{--tw-bg-opacity:1;background-color:#fff;background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.hover\:bg-surface-selected:hover{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))}.hover\:pl-sm:hover{padding-left:.5rem;padding-left:var(--spacing-sm)}.hover\:font-semibold:hover{font-weight:600}.hover\:\!text-color-black:hover{--tw-text-opacity:1!important;color:#000!important;color:rgba(var(--color-black),var(--tw-text-opacity))!important}.hover\:text-color-black:hover{--tw-text-opacity:1;color:#000;color:rgba(var(--color-black),var(--tw-text-opacity))}.hover\:text-color-brand-bold:hover{--tw-text-opacity:1;color:#eab308;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.hover\:text-color-link-bold:hover{--tw-text-opacity:1;color:#0156ce;color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.hover\:text-color-link-bolder:hover{--tw-text-opacity:1;color:#014bb5;color:rgba(var(--color-text-link-bolder),var(--tw-text-opacity))}.hover\:text-color-subtle:hover{--tw-text-opacity:1;color:#626f86;color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.hover\:underline:hover{text-decoration-line:underline}.hover\:grayscale-0:hover{--tw-grayscale:grayscale(0);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) grayscale(0) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.focus\:bg-brand-strong:focus{--tw-bg-opacity:1;background-color:#a86a07;background-color:rgba(var(--color-brand-strong),var(--tw-bg-opacity))}.focus\:outline-none:focus{outline:2px solid transparent;outline-offset:2px}.focus\:outline-color-brand:focus{outline-color:#eab308;outline-color:rgba(var(--color-border-brand),1)}.focus\:ring-2:focus{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.focus\:ring-text-color-border-selected:focus{--tw-ring-opacity:1;--tw-ring-color:rgba(var(--color-border-selected),var(--tw-ring-opacity))}.focus-visible\:bg-brand-bold:focus-visible{--tw-bg-opacity:1;background-color:#eab308;background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.focus-visible\:bg-brand-boldest:focus-visible{--tw-bg-opacity:1;background-color:#c48404;background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.focus-visible\:bg-error-bold:focus-visible{--tw-bg-opacity:1;background-color:#e11900;background-color:rgba(var(--color-bg-error-bold),var(--tw-bg-opacity))}.focus-visible\:bg-surface-default:focus-visible{--tw-bg-opacity:1;background-color:#fff;background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.focus-visible\:bg-surface-selected:focus-visible{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity))}.focus-visible\:outline-none:focus-visible{outline:2px solid transparent;outline-offset:2px}.focus-visible\:outline:focus-visible{outline-style:solid}.focus-visible\:outline-2:focus-visible{outline-width:2px}.focus-visible\:outline-color-selected:focus-visible{outline-color:#eab308;outline-color:rgba(var(--color-border-selected),1)}.focus-visible\:ring-2:focus-visible{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.focus-visible\:ring-offset-2:focus-visible{--tw-ring-offset-width:2px}.focus-visible\:ring-offset-brand-bold:focus-visible{--tw-ring-offset-color:rgba(var(--color-brand-bold),1)}.focus-visible\:ring-offset-white:focus-visible{--tw-ring-offset-color:rgba(var(--color-white),1)}.active\:\!bg-brand-subtlest:active{--tw-bg-opacity:1!important;background-color:#fef9c3!important;background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))!important}.active\:\!bg-inherit:active{background-color:inherit!important}.active\:\!bg-transparent:active{background-color:transparent!important}.active\:bg-brand-boldest:active{--tw-bg-opacity:1;background-color:#c48404;background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.active\:bg-brand-strong:active{--tw-bg-opacity:1;background-color:#a86a07;background-color:rgba(var(--color-brand-strong),var(--tw-bg-opacity))}.active\:bg-brand-subtler:active{--tw-bg-opacity:1;background-color:#fef08a;background-color:rgba(var(--color-brand-subtler),var(--tw-bg-opacity))}.active\:bg-brand-subtlest:active{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-brand-subtlest),var(--tw-bg-opacity))}.active\:bg-content-bolder:active{--tw-bg-opacity:1;background-color:#d19507;background-color:rgba(var(--color-bg-content-bolder),var(--tw-bg-opacity))}.active\:bg-content-subtlest:active{--tw-bg-opacity:1;background-color:#fef9c3;background-color:rgba(var(--color-bg-content-subtlest),var(--tw-bg-opacity))}.active\:text-color-brand-boldest:active{--tw-text-opacity:1;color:#c48404;color:rgba(var(--color-text-brand-boldest),var(--tw-text-opacity))}.disabled\:border-color-default:disabled{--tw-border-opacity:1;border-color:#dcdfe4;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.disabled\:bg-surface-subtle:disabled{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.disabled\:text-color-disabled:disabled{--tw-text-opacity:1;color:#b3b9c4;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.group:hover .group-hover\:after\:bg-brand-bolder:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:#d19507;background-color:rgba(var(--color-brand-bolder),var(--tw-bg-opacity))}.group:active .group-active\:after\:bg-brand-boldest:after{content:var(--tw-content);--tw-bg-opacity:1;background-color:#c48404;background-color:rgba(var(--color-brand-boldest),var(--tw-bg-opacity))}.aria-disabled\:pointer-events-none[aria-disabled=true]{pointer-events:none}.aria-disabled\:cursor-default[aria-disabled=true]{cursor:default}.aria-disabled\:text-color-disabled[aria-disabled=true]{--tw-text-opacity:1;color:#b3b9c4;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.ui-open\:text-color-brand-bold[data-headlessui-state~=open]{--tw-text-opacity:1;color:#eab308;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}:where([data-headlessui-state~=open]) .ui-open\:text-color-brand-bold{--tw-text-opacity:1;color:#eab308;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.ui-disabled\:pointer-events-none[data-headlessui-state~=disabled]{pointer-events:none}.ui-disabled\:cursor-default[data-headlessui-state~=disabled]{cursor:default}.ui-disabled\:text-color-disabled[data-headlessui-state~=disabled]{--tw-text-opacity:1;color:#b3b9c4;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}:where([data-headlessui-state~=disabled]) .ui-disabled\:pointer-events-none{pointer-events:none}:where([data-headlessui-state~=disabled]) .ui-disabled\:cursor-default{cursor:default}:where([data-headlessui-state~=disabled]) .ui-disabled\:text-color-disabled{--tw-text-opacity:1;color:#b3b9c4;color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}:where([data-headlessui-focus-visible]) .ui-focus-visible\:outline-color-brand:focus{outline-color:#eab308;outline-color:rgba(var(--color-border-brand),1)}:where([data-headlessui-focus-visible]) .ui-focus-visible\:ring-2:focus{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}:where([data-headlessui-focus-visible]) .ui-focus-visible\:ring-brand-bold:focus{--tw-ring-opacity:1;--tw-ring-color:rgba(var(--color-brand-bold),var(--tw-ring-opacity))}:where([data-headlessui-focus-visible]) .ui-focus-visible\:ring-opacity-75:focus{--tw-ring-opacity:0.75}.slider-horizontal .h\:-right-2{right:-.5rem}.slider-horizontal .h\:-top-1{top:-.25rem}.slider-horizontal .h\:-top-1\.5{top:-.375rem}.slider-horizontal .h\:left-1\/2{left:50%}.slider-horizontal .h\:h-0{height:0}.slider-horizontal .h\:h-4{height:1rem}.slider-horizontal .h\:w-4{width:1rem}.slider-horizontal .h\:-translate-x-1\/2{--tw-translate-x:-50%;transform:translate(-50%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-horizontal .h\:arrow-bottom:before{border:5px solid transparent;border-top-color:inherit;bottom:-10px}.slider-horizontal .h\:arrow-bottom:before,.slider-horizontal .h\:arrow-top:before{content:"";height:0;left:50%;position:absolute;transform:translate(-50%);width:0}.slider-horizontal .h\:arrow-top:before{border:5px solid transparent;border-bottom-color:inherit;top:-10px}.slider-vertical .v\:-right-1{right:-.25rem}.slider-vertical .v\:-right-1\.25{right:-.3125rem}.slider-vertical .v\:-top-2{top:-.5rem}.slider-vertical .v\:-top-full{top:-100%}.slider-vertical .v\:top-1\/2{top:50%}.slider-vertical .v\:h-4{height:1rem}.slider-vertical .v\:w-0{width:0}.slider-vertical .v\:w-4{width:1rem}.slider-vertical .v\:-translate-y-1\/2{--tw-translate-y:-50%;transform:translate(var(--tw-translate-x),-50%) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-vertical .v\:cursor-ns-resize{cursor:ns-resize}.slider-vertical .v\:arrow-left:before{border:5px solid transparent;border-right-color:inherit;left:-10px}.slider-vertical .v\:arrow-left:before,.slider-vertical .v\:arrow-right:before{content:"";height:0;position:absolute;top:50%;transform:translateY(-50%);width:0}.slider-vertical .v\:arrow-right:before{border:5px solid transparent;border-left-color:inherit;right:-10px}.slider-horizontal .slider-origin>.merge-h\:bottom-3{bottom:.75rem}.slider-horizontal .slider-origin>.merge-h\:bottom-3\.5{bottom:.875rem}.slider-horizontal .slider-origin>.merge-h\:left-auto{left:auto}.slider-horizontal .slider-origin>.merge-h\:top-5{top:1.25rem}.slider-horizontal .slider-origin>.merge-h\:translate-x-1\/2{--tw-translate-x:50%;transform:translate(50%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-vertical .slider-origin>.merge-v\:left-7{left:1.75rem}.slider-vertical .slider-origin>.merge-v\:right-1{right:.25rem}.slider-vertical .slider-origin>.merge-v\:top-auto{top:auto}.slider-vertical .slider-origin>.merge-v\:-translate-x-4{--tw-translate-x:-1rem;transform:translate(-1rem,var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.slider-horizontal.slider-txt-rtl .txt-rtl-h\:-left-2{left:-.5rem}.slider-horizontal.slider-txt-rtl .txt-rtl-h\:left-0{left:0}.slider-horizontal.slider-txt-rtl .txt-rtl-h\:right-auto{right:auto}.slider-tap .tap\:transition-transform{transition-duration:.15s;transition-property:transform;transition-timing-function:cubic-bezier(.4,0,.2,1)}.slider-tap .tap\:duration-300{transition-duration:.3s}.slider-tooltip-focus:not(.slider-focused) .tt-focus\:hidden{display:none!important}.slider-tooltip-focus.slider-focused:not(.slider-tooltip-hidden) .tt-focused\:block{display:block!important}.slider-tooltip-drag:not(.slider-state-drag) .tt-drag\:hidden{display:none!important}.slider-tooltip-drag.slider-state-drag .tt-dragging\:block\:not$\.slider-tooltip-hidden${display:block!important}@media not all and (min-width:1280px){.max-xl\:w-full{width:100%}}@media not all and (min-width:1024px){.max-lg\:items-center{align-items:center}.max-lg\:gap-x-6{-moz-column-gap:1.5rem;column-gap:1.5rem}.max-lg\:pt-lg{padding-top:1.5rem;padding-top:var(--spacing-lg)}}@media (min-width:576px){.sm\:sticky{position:sticky}.sm\:top-20{top:5rem}.sm\:w-20{width:5rem}.sm\:w-2xl{width:2.5rem;width:var(--spacing-2xl)}.sm\:w-\[100\%\]{width:100%}.sm\:w-\[50\%\]{width:50%}.sm\:\!max-w-\[20\%\]{max-width:20%!important}.sm\:max-w-\[33\%\]{max-width:33%}.sm\:grid-cols-2{grid-template-columns:repeat(2,minmax(0,1fr))}.sm\:border-0{border-width:0}.sm\:border-t{border-top-width:1px}.sm\:border-\[\#000\]{--tw-border-opacity:1;border-color:#000;border-color:rgb(0 0 0/var(--tw-border-opacity))}.sm\:pr-md{padding-right:1rem;padding-right:var(--spacing-md)}.sm\:pt-0{padding-top:0}.sm\:pt-\[\.625rem\]{padding-top:.625rem}}@media (min-width:768px){.md\:h-9{height:2.25rem}.md\:w-9{width:2.25rem}.md\:w-\[100\%\]{width:100%}.md\:w-\[50\%\]{width:50%}.md\:flex-row{flex-direction:row}.md\:flex-row-reverse{flex-direction:row-reverse}}@media (min-width:1024px){.lg\:absolute{position:absolute}.lg\:sticky{position:sticky}.lg\:\!bottom-\[50vh\]{bottom:50vh!important}.lg\:bottom-xl{bottom:2rem;bottom:var(--spacing-xl)}.lg\:left-xl{left:2rem;left:var(--spacing-xl)}.lg\:top-7xl{top:5rem;top:var(--spacing-7xl)}.lg\:top-\[10\%\]{top:10%}.lg\:top-\[20\%\]{top:20%}.lg\:top-\[30\%\]{top:30%}.lg\:top-\[4\.5rem\]{top:4.5rem}.lg\:top-\[40\%\]{top:40%}.lg\:top-\[50\%\]{top:50%}.lg\:top-\[60\%\]{top:60%}.lg\:top-\[70\%\]{top:70%}.lg\:order-first{order:-9999}.lg\:m-0{margin:0}.lg\:m-lg{margin:1.5rem;margin:var(--spacing-lg)}.lg\:mx-auto{margin-left:auto;margin-right:auto}.lg\:my-0{margin-bottom:0;margin-top:0}.lg\:my-12{margin-bottom:3rem;margin-top:3rem}.lg\:my-7xl{margin-bottom:5rem;margin-bottom:var(--spacing-7xl);margin-top:5rem;margin-top:var(--spacing-7xl)}.lg\:my-\[18\.75rem\]{margin-bottom:18.75rem;margin-top:18.75rem}.lg\:-mt-4xl{margin-top:-3.5rem;margin-top:calc(var(--spacing-4xl)*-1)}.lg\:mb-0{margin-bottom:0}.lg\:mb-10xl{margin-bottom:6.5rem;margin-bottom:var(--spacing-10xl)}.lg\:mb-lg{margin-bottom:1.5rem;margin-bottom:var(--spacing-lg)}.lg\:ml-3xl{margin-left:3rem;margin-left:var(--spacing-3xl)}.lg\:ml-lg{margin-left:1.5rem;margin-left:var(--spacing-lg)}.lg\:ml-sm{margin-left:.5rem;margin-left:var(--spacing-sm)}.lg\:mr-8xl{margin-right:5.5rem;margin-right:var(--spacing-8xl)}.lg\:mr-\[4\.6875rem\]{margin-right:4.6875rem}.lg\:mr-lg{margin-right:1.5rem;margin-right:var(--spacing-lg)}.lg\:mr-xl{margin-right:2rem;margin-right:var(--spacing-xl)}.lg\:mt-0{margin-top:0}.lg\:mt-\[-3rem\]{margin-top:-3rem}.lg\:mt-lg{margin-top:1.5rem;margin-top:var(--spacing-lg)}.lg\:mt-md{margin-top:1rem;margin-top:var(--spacing-md)}.lg\:\!block{display:block!important}.lg\:block{display:block}.lg\:flex{display:flex}.lg\:\!inline-flex{display:inline-flex!important}.lg\:grid{display:grid}.lg\:\!hidden{display:none!important}.lg\:hidden{display:none}.lg\:aspect-\[1\/1\.414\]{aspect-ratio:1/1.414}.lg\:aspect-square{aspect-ratio:1/1}.lg\:h-12{height:3rem}.lg\:h-\[296px\]{height:296px}.lg\:h-\[7\.5rem\]{height:7.5rem}.lg\:max-h-\[100\%\]{max-height:100%}.lg\:max-h-\[30\%\]{max-height:30%}.lg\:max-h-\[40\%\]{max-height:40%}.lg\:max-h-\[50\%\]{max-height:50%}.lg\:max-h-\[60\%\]{max-height:60%}.lg\:max-h-\[70\%\]{max-height:70%}.lg\:max-h-\[80\%\]{max-height:80%}.lg\:max-h-\[90\%\]{max-height:90%}.lg\:min-h-screen{min-height:100vh}.lg\:\!w-\[20\%\]{width:20%!important}.lg\:\!w-\[75\%\]{width:75%!important}.lg\:\!w-fit{width:-moz-fit-content!important;width:fit-content!important}.lg\:w-1\/2{width:50%}.lg\:w-1\/4{width:25%}.lg\:w-1\/5{width:20%}.lg\:w-12{width:3rem}.lg\:w-2\/3{width:66.666667%}.lg\:w-4\/5{width:80%}.lg\:w-\[100\%\]{width:100%}.lg\:w-\[19\.0625rem\]{width:19.0625rem}.lg\:w-\[22\.5rem\]{width:22.5rem}.lg\:w-\[25\%\]{width:25%}.lg\:w-\[31\.25rem\]{width:31.25rem}.lg\:w-\[315px\]{width:315px}.lg\:w-\[32rem\]{width:32rem}.lg\:w-\[33\%\]{width:33%}.lg\:w-\[333px\]{width:333px}.lg\:w-\[360px\]{width:360px}.lg\:w-\[50\%\]{width:50%}.lg\:w-fit{width:-moz-fit-content;width:fit-content}.lg\:w-full{width:100%}.lg\:w-max{width:-moz-max-content;width:max-content}.lg\:\!min-w-\[40\%\]{min-width:40%!important}.lg\:max-w-2xl{max-width:42rem}.lg\:max-w-3xl{max-width:48rem}.lg\:max-w-4xl{max-width:56rem}.lg\:max-w-5xl{max-width:64rem}.lg\:max-w-6xl{max-width:72rem}.lg\:max-w-7xl{max-width:80rem}.lg\:max-w-\[28\.5rem\]{max-width:28.5rem}.lg\:max-w-\[30\%\]{max-width:30%}.lg\:max-w-\[32\%\]{max-width:32%}.lg\:max-w-\[80\%\]{max-width:80%}.lg\:max-w-lg{max-width:32rem}.lg\:max-w-md{max-width:28rem}.lg\:max-w-sm{max-width:24rem}.lg\:max-w-xl{max-width:36rem}.lg\:max-w-xs{max-width:20rem}.lg\:flex-1{flex:1 1 0%}.lg\:flex-auto{flex:1 1 auto}.lg\:flex-none{flex:none}.lg\:basis-1\/2{flex-basis:50%}.lg\:basis-1\/4{flex-basis:25%}.lg\:basis-\[15\.625rem\]{flex-basis:15.625rem}.lg\:list-disc{list-style-type:disc}.lg\:grid-cols-3{grid-template-columns:repeat(3,minmax(0,1fr))}.lg\:flex-row{flex-direction:row}.lg\:flex-row-reverse{flex-direction:row-reverse}.lg\:flex-col{flex-direction:column}.lg\:flex-wrap{flex-wrap:wrap}.lg\:flex-nowrap{flex-wrap:nowrap}.lg\:items-center{align-items:center}.lg\:justify-end{justify-content:flex-end}.lg\:justify-between{justify-content:space-between}.lg\:gap-0{gap:0}.lg\:gap-2xl{gap:2.5rem;gap:var(--spacing-2xl)}.lg\:gap-lg{gap:1.5rem;gap:var(--spacing-lg)}.lg\:gap-xl{gap:2rem;gap:var(--spacing-xl)}.lg\:gap-x-lg{-moz-column-gap:1.5rem;column-gap:1.5rem;-moz-column-gap:var(--spacing-lg);column-gap:var(--spacing-lg)}.lg\:gap-y-lg{row-gap:1.5rem;row-gap:var(--spacing-lg)}.lg\:\!space-y-0>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0!important;margin-bottom:0!important;margin-bottom:calc(0px*var(--tw-space-y-reverse))!important;margin-top:0!important;margin-top:calc(0px*(1 - var(--tw-space-y-reverse)))!important}.lg\:space-x-lg>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:1.5rem;margin-left:calc(var(--spacing-lg)*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(var(--spacing-lg)*var(--tw-space-x-reverse))}.lg\:space-x-xl>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:2rem;margin-left:calc(var(--spacing-xl)*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(var(--spacing-xl)*var(--tw-space-x-reverse))}.lg\:space-y-0>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(0px*var(--tw-space-y-reverse));margin-top:0;margin-top:calc(0px*(1 - var(--tw-space-y-reverse)))}.lg\:space-y-2xl>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-bottom:0;margin-bottom:calc(var(--spacing-2xl)*var(--tw-space-y-reverse));margin-top:2.5rem;margin-top:calc(var(--spacing-2xl)*(1 - var(--tw-space-y-reverse)))}.lg\:rounded-2xl{border-radius:1rem}.lg\:rounded-3xl{border-radius:1.5rem}.lg\:border{border-width:1px}.lg\:border-0{border-width:0}.lg\:border-b{border-bottom-width:1px}.lg\:border-l{border-left-width:1px}.lg\:border-t-0{border-top-width:0}.lg\:border-none{border-style:none}.lg\:bg-surface-subtle{--tw-bg-opacity:1;background-color:#f8f9fd;background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.lg\:p-0{padding:0}.lg\:p-2xl{padding:2.5rem;padding:var(--spacing-2xl)}.lg\:p-lg{padding:1.5rem;padding:var(--spacing-lg)}.lg\:px-0{padding-left:0;padding-right:0}.lg\:px-10{padding-left:2.5rem;padding-right:2.5rem}.lg\:px-4{padding-left:1rem;padding-right:1rem}.lg\:px-4xl{padding-left:3.5rem;padding-left:var(--spacing-4xl);padding-right:3.5rem;padding-right:var(--spacing-4xl)}.lg\:px-\[\.9375rem\]{padding-left:.9375rem;padding-right:.9375rem}.lg\:px-lg{padding-left:1.5rem;padding-left:var(--spacing-lg);padding-right:1.5rem;padding-right:var(--spacing-lg)}.lg\:py-0{padding-bottom:0;padding-top:0}.lg\:py-10xl{padding-bottom:6.5rem;padding-bottom:var(--spacing-10xl);padding-top:6.5rem;padding-top:var(--spacing-10xl)}.lg\:py-12{padding-bottom:3rem;padding-top:3rem}.lg\:py-2xl{padding-bottom:2.5rem;padding-bottom:var(--spacing-2xl);padding-top:2.5rem;padding-top:var(--spacing-2xl)}.lg\:py-32{padding-bottom:8rem;padding-top:8rem}.lg\:py-3xl{padding-bottom:3rem;padding-bottom:var(--spacing-3xl);padding-top:3rem;padding-top:var(--spacing-3xl)}.lg\:py-4xl{padding-bottom:3.5rem;padding-bottom:var(--spacing-4xl);padding-top:3.5rem;padding-top:var(--spacing-4xl)}.lg\:py-5xl{padding-bottom:4rem;padding-bottom:var(--spacing-5xl);padding-top:4rem;padding-top:var(--spacing-5xl)}.lg\:py-7xl{padding-bottom:5rem;padding-bottom:var(--spacing-7xl);padding-top:5rem;padding-top:var(--spacing-7xl)}.lg\:py-lg{padding-bottom:1.5rem;padding-bottom:var(--spacing-lg);padding-top:1.5rem;padding-top:var(--spacing-lg)}.lg\:py-xl{padding-bottom:2rem;padding-bottom:var(--spacing-xl);padding-top:2rem;padding-top:var(--spacing-xl)}.lg\:pb-0{padding-bottom:0}.lg\:pb-2xl{padding-bottom:2.5rem;padding-bottom:var(--spacing-2xl)}.lg\:pb-3xl{padding-bottom:3rem;padding-bottom:var(--spacing-3xl)}.lg\:pb-5xl{padding-bottom:4rem;padding-bottom:var(--spacing-5xl)}.lg\:pb-7xl{padding-bottom:5rem;padding-bottom:var(--spacing-7xl)}.lg\:pb-\[12\.5rem\]{padding-bottom:12.5rem}.lg\:pb-\[6\.3125rem\]{padding-bottom:6.3125rem}.lg\:pb-lg{padding-bottom:1.5rem;padding-bottom:var(--spacing-lg)}.lg\:pb-md{padding-bottom:1rem;padding-bottom:var(--spacing-md)}.lg\:pb-sm{padding-bottom:.5rem;padding-bottom:var(--spacing-sm)}.lg\:pl-10,.lg\:pl-2xl{padding-left:2.5rem}.lg\:pl-2xl{padding-left:var(--spacing-2xl)}.lg\:pl-lg{padding-left:1.5rem;padding-left:var(--spacing-lg)}.lg\:pl-sm{padding-left:.5rem;padding-left:var(--spacing-sm)}.lg\:pl-xl{padding-left:2rem;padding-left:var(--spacing-xl)}.lg\:pr-0{padding-right:0}.lg\:pr-lg{padding-right:1.5rem;padding-right:var(--spacing-lg)}.lg\:pr-xl{padding-right:2rem;padding-right:var(--spacing-xl)}.lg\:pt-0{padding-top:0}.lg\:pt-2xl{padding-top:2.5rem;padding-top:var(--spacing-2xl)}.lg\:pt-3xl{padding-top:3rem;padding-top:var(--spacing-3xl)}.lg\:pt-5xl{padding-top:4rem;padding-top:var(--spacing-5xl)}.lg\:pt-7xl{padding-top:5rem;padding-top:var(--spacing-7xl)}.lg\:pt-\[5rem\]{padding-top:5rem}.lg\:pt-\[7\.5rem\]{padding-top:7.5rem}.lg\:pt-\[8\.125rem\]{padding-top:8.125rem}.lg\:pt-lg{padding-top:1.5rem;padding-top:var(--spacing-lg)}.lg\:pt-md{padding-top:1rem;padding-top:var(--spacing-md)}.lg\:pt-xl{padding-top:2rem;padding-top:var(--spacing-xl)}.lg\:text-center{text-align:center}.lg\:\!text-3xl{font-size:1.875rem!important;line-height:2.25rem!important}}@media (min-width:1280px){.xl\:mr-7xl{margin-right:5rem;margin-right:var(--spacing-7xl)}.xl\:mr-lg{margin-right:1.5rem;margin-right:var(--spacing-lg)}.xl\:h-16{height:4rem}.xl\:w-16{width:4rem}.xl\:w-4{width:1rem}.xl\:w-\[100\%\]{width:100%}.xl\:w-\[25\%\]{width:25%}.xl\:w-\[27\.6875rem\]{width:27.6875rem}.xl\:w-\[33\%\]{width:33%}.xl\:w-\[50\%\]{width:50%}.xl\:space-x-3xl>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:3rem;margin-left:calc(var(--spacing-3xl)*(1 - var(--tw-space-x-reverse)));margin-right:0;margin-right:calc(var(--spacing-3xl)*var(--tw-space-x-reverse))}}@media (min-width:1440px){.xxl\:w-\[33\%\]{width:33%}}.\[\&\:\:-webkit-inner-spin-button\]\:appearance-none::-webkit-inner-spin-button,.\[\&\:\:-webkit-outer-spin-button\]\:appearance-none::-webkit-outer-spin-button{-webkit-appearance:none;appearance:none}.\[\&\>a\]\:block>a{display:block}.\[\&\>a\]\:w-full>a{width:100%}.\[\&\>a\]\:px-2>a{padding-left:.5rem;padding-right:.5rem}.\[\&\>a\]\:px-4>a{padding-left:1rem;padding-right:1rem}.\[\&\>a\]\:py-md>a{padding-bottom:1rem;padding-bottom:var(--spacing-md);padding-top:1rem;padding-top:var(--spacing-md)}.\[\&\>div\]\:z-1>div{z-index:1}.\[\&\>div\]\:z-10>div{z-index:10}.\[\&\>div\]\:w-fit>div{width:-moz-fit-content;width:fit-content}.\[\&\>ol\>li\]\:truncate>ol>li{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.\[\&\>span\]\:overflow-hidden>span{overflow:hidden}.\[\&\>span\]\:truncate>span{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.\[\&_input\]\:\!w-\[1\.15em\] input{width:1.15em!important}.\[\&_input\]\:text-center input{text-align:center}.\[\&_span\]\:hover\:text-color-brand-bold:hover span,.\[\&_span\]\:text-color-brand-bold span{--tw-text-opacity:1;color:#eab308;color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}</style> <style>html{scroll-behavior:smooth}.common-field{display:flex;flex-direction:column;font-size:.875rem;gap:.25rem;line-height:1.25rem;position:relative;width:100%}.common-field--success .common-field__dropdown-input,.common-field--success .common-field__input,.common-field--success .common-field__textarea{--tw-text-opacity:1;color:rgba(var(--color-text-success),1);color:rgba(var(--color-text-success),var(--tw-text-opacity));outline-color:rgba(var(--color-border-success),1);outline-style:solid}.common-field--success>.common-field__hint{--tw-text-opacity:1;color:rgba(var(--color-text-success),1);color:rgba(var(--color-text-success),var(--tw-text-opacity))}.common-field--error .common-field__dropdown-input,.common-field--error .common-field__input,.common-field--error .common-field__textarea{--tw-text-opacity:1;color:rgba(var(--color-text-error),1);color:rgba(var(--color-text-error),var(--tw-text-opacity));outline-color:rgba(var(--color-border-error),1);outline-style:solid}.common-field--error>.common-field__hint{--tw-text-opacity:1;color:rgba(var(--color-text-error),1);color:rgba(var(--color-text-error),var(--tw-text-opacity))}.common-field.common-field--readonly .common-field__dropdown-input,.common-field.common-field--readonly .common-field__input,.common-field.common-field--readonly .common-field__textarea,.common-field.common-field--readonly input,.common-field.common-field--readonly textarea{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.common-field input::-moz-placeholder,.common-field textarea::-moz-placeholder{--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.common-field input::placeholder,.common-field textarea::placeholder{--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.common-field__wrapper{width:100%}.common-field__label{display:block;font-size:.75rem;line-height:1rem;margin-bottom:var(--spacing-xs);white-space:nowrap}.common-field__hint{font-size:.75rem;line-height:1rem;--tw-text-opacity:1;color:rgba(var(--color-text-subtlest),1);color:rgba(var(--color-text-subtlest),var(--tw-text-opacity));margin-top:var(--spacing-xs)}.common-field__options{border-radius:.25rem;border-width:1px;max-height:15rem;min-width:-moz-fit-content;min-width:fit-content;overflow:auto;position:absolute;width:100%;z-index:20;--tw-border-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-border-opacity));--tw-bg-opacity:1;background-color:rgba(var(--color-white),1);background-color:rgba(var(--color-white),var(--tw-bg-opacity));font-size:.875rem;line-height:1.25rem;padding:.25rem;--tw-shadow:0 10px 15px -3px rgba(0,0,0,.1),0 4px 6px -4px rgba(0,0,0,.1);--tw-shadow-colored:0 10px 15px -3px var(--tw-shadow-color),0 4px 6px -4px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 10px 15px -3px rgba(0,0,0,.1),0 4px 6px -4px rgba(0,0,0,.1);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}.common-field__options:focus{outline:2px solid transparent;outline-offset:2px}.common-field__input{width:100%;--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity));outline-color:rgba(var(--color-border-brand),1);outline-offset:-1px;outline-width:2px}.common-field__dropdown-input{align-items:center;border-radius:.25rem;display:flex;gap:.5rem;justify-content:space-between;margin-bottom:2px;padding-right:var(--spacing-sm);white-space:nowrap}.common-field__dropdown-input,.common-field__textarea{width:100%;--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity));outline-color:rgba(var(--color-border-brand),1);outline-offset:-1px;outline-width:2px;padding-left:var(--spacing-md)}.common-field__textarea{padding-right:var(--spacing-md)}.common-field input,.common-field textarea{width:100%;--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.common-field--outlined .common-field__dropdown-input,.common-field--outlined .common-field__input,.common-field--outlined .common-field__textarea{border-width:1px;--tw-border-opacity:1;background-color:transparent;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.common-field--outlined input,.common-field--outlined textarea{background-color:transparent}.common-field--fit-content{max-width:-moz-fit-content;max-width:fit-content}.common-field--inline .common-field__wrapper{align-items:center;display:flex;flex-direction:row;gap:.5rem}.common-field--inline .common-field__wrapper .common-field__label{margin-bottom:0}.common-field--disabled,.common-field--disabled .common-field__dropdown-input,.common-field--disabled .common-field__hint,.common-field--disabled .common-field__placeholder,.common-field--disabled input,.common-field--disabled textarea{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.common-field--disabled input::-moz-placeholder,.common-field--disabled textarea::-moz-placeholder{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.common-field--disabled input::placeholder,.common-field--disabled textarea::placeholder{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.m-button-group .m-button.m-button--primary:not(.m-button--active){--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity));--tw-text-opacity:1;color:rgba(var(--color-text-default),1);color:rgba(var(--color-text-default),var(--tw-text-opacity))}.m-button-group .m-button.m-button--primary:not(.m-button--active):hover{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.m-button-group .m-button.m-button--active{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity))}.m-button{align-items:center;display:flex;font-size:.875rem;font-weight:400;line-height:1.25rem;outline-color:rgba(var(--color-border-brand),1);position:relative;transition-duration:.1s;transition-timing-function:cubic-bezier(0,0,.2,1);width:-moz-fit-content;width:fit-content}.m-button--sm{height:var(--spacing-lg)}.m-button--md,.m-button--sm{padding-left:var(--spacing-md);padding-right:var(--spacing-md)}.m-button--md{height:var(--spacing-xl)}.m-button--lg{height:var(--spacing-2xl);padding-left:var(--spacing-md);padding-right:var(--spacing-md)}.m-button--disabled{pointer-events:none;--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.m-button--tonal{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-sunken),1);background-color:rgba(var(--color-bg-content-sunken),var(--tw-bg-opacity))}.m-button--tonal:not(.m-button--disabled):hover{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtler),1);background-color:rgba(var(--color-bg-content-subtler),var(--tw-bg-opacity))}.m-button--tonal:not(.m-button--disabled).m-button--active,.m-button--tonal:not(.m-button--disabled):active{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtle),1);background-color:rgba(var(--color-bg-content-subtle),var(--tw-bg-opacity))}.m-button--tonal.m-button--disabled,.m-button--tonal:disabled{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-disabled),1);background-color:rgba(var(--color-surface-disabled),var(--tw-bg-opacity))}.m-button--primary{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity));--tw-text-opacity:1;color:rgba(var(--color-text-on-brand),1);color:rgba(var(--color-text-on-brand),var(--tw-text-opacity))}.m-button--primary:not(.m-button--disabled):hover{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bolder),1);background-color:rgba(var(--color-brand-bolder),var(--tw-bg-opacity))}.m-button--primary:not(.m-button--disabled).m-button--active,.m-button--primary:not(.m-button--disabled):active{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-strong),1);background-color:rgba(var(--color-brand-strong),var(--tw-bg-opacity))}.m-button--primary.m-button--disabled,.m-button--primary:disabled{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.m-button--accent{--tw-bg-opacity:1;background-color:rgba(var(--color-accent-bold),1);background-color:rgba(var(--color-accent-bold),var(--tw-bg-opacity));--tw-text-opacity:1;color:rgba(var(--color-text-on-accent),1);color:rgba(var(--color-text-on-accent),var(--tw-text-opacity));outline-color:rgba(var(--color-border-accent),1)}.m-button--accent:not(.m-button--disabled):hover{--tw-bg-opacity:1;background-color:rgba(var(--color-accent-bolder),1);background-color:rgba(var(--color-accent-bolder),var(--tw-bg-opacity))}.m-button--accent:not(.m-button--disabled).m-button--active,.m-button--accent:not(.m-button--disabled):active{--tw-bg-opacity:1;background-color:rgba(var(--color-accent-strong),1);background-color:rgba(var(--color-accent-strong),var(--tw-bg-opacity))}.m-button--accent.m-button--disabled,.m-button--accent:disabled{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.m-button--secondary{border-width:1px;--tw-border-opacity:1;border-color:rgba(var(--color-border-bold),var(--tw-border-opacity))}.m-button--secondary:not(.m-button--disabled):hover{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.m-button--secondary:not(.m-button--disabled).m-button--active,.m-button--secondary:not(.m-button--disabled):active{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity))}.m-button--secondary.m-button--disabled,.m-button--secondary:disabled{--tw-border-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.m-button--tertiary{position:relative;--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity));height:var(--spacing-lg);outline-offset:2px;padding:0}.m-button--tertiary:after{background-image:linear-gradient(to right,rgba(var(--color-text-link-bold),1) var(--tw-gradient-from-position),rgba(var(--color-text-link-bold),1) var(--tw-gradient-to-position));background-image:linear-gradient(to right,var(--tw-gradient-stops));bottom:-.125rem;content:"";height:.125rem;left:0;position:absolute;right:0;--tw-gradient-from:rgba(var(--color-text-link-bold),1) var(--tw-gradient-from-position);--tw-gradient-to:rgba(var(--color-text-link-bold),0) var(--tw-gradient-to-position);--tw-gradient-stops:var(--tw-gradient-from),var(--tw-gradient-to);--tw-gradient-to:rgba(var(--color-text-link-bold),1) var(--tw-gradient-to-position);opacity:0;transition-duration:.15s;transition-timing-function:cubic-bezier(0,0,.2,1)}.m-button--tertiary:not(.m-button--disabled):hover:after{content:var(--tw-content);opacity:1}.m-button--tertiary:not(.m-button--disabled):active{--tw-text-opacity:1;color:rgba(var(--color-text-link-boldest),1);color:rgba(var(--color-text-link-boldest),var(--tw-text-opacity))}.m-button--tertiary:not(.m-button--disabled).m-button--active{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.m-button--tertiary:not(.m-button--disabled).m-button--active:after{--tw-gradient-from:rgba(var(--color-text-link-bold),1) var(--tw-gradient-from-position);--tw-gradient-to:rgba(var(--color-text-link-bold),0) var(--tw-gradient-to-position);--tw-gradient-stops:var(--tw-gradient-from),var(--tw-gradient-to);--tw-gradient-to:rgba(var(--color-text-link-bold),1) var(--tw-gradient-to-position);opacity:1}.m-button--tertiary.m-button--disabled,.m-button--tertiary:disabled{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity));opacity:.6}.m-button--tertiary-subtle{position:relative;--tw-text-opacity:1;color:rgba(var(--color-text-link-subtle),1);color:rgba(var(--color-text-link-subtle),var(--tw-text-opacity));height:var(--spacing-lg);outline-offset:2px;padding:0}.m-button--tertiary-subtle:not(.m-button--disabled):active,.m-button--tertiary-subtle:not(.m-button--disabled):hover{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.m-button--tertiary-subtle:not(.m-button--disabled).m-button--active{--tw-text-opacity:1;color:rgba(var(--color-text-link-boldest),1);color:rgba(var(--color-text-link-boldest),var(--tw-text-opacity))}.m-button--tertiary-subtle.m-button--disabled,.m-button--tertiary-subtle:disabled{--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity));opacity:.6}.m-button--full-width{width:100%}.m-button--full-width.m-button--link a{text-align:center;width:100%}.m-button--link{padding:0}.m-button--link a{align-items:center;color:inherit;display:flex;font-size:.875rem;gap:.5rem;height:100%;justify-content:center;line-height:1.25rem;width:100%}.m-button--link.m-button--lg a,.m-button--link.m-button--md a,.m-button--link.m-button--sm a{padding-left:var(--spacing-md);padding-right:var(--spacing-md)}.m-button--link.m-button--is-icon a{font-size:.875rem;line-height:1.25rem;padding-left:var(--spacing-sm);padding-right:var(--spacing-sm)}.m-button--link.m-button--tertiary a,.m-button--link.m-button--tertiary-subtle a{padding:0}.m-button--link.m-button--is-link-icon a{padding-left:var(--spacing-sm);padding-right:var(--spacing-sm)}.m-button--link.m-button--disabled a{pointer-events:none;--tw-text-opacity:1;color:rgba(var(--color-text-disabled),1);color:rgba(var(--color-text-disabled),var(--tw-text-opacity))}.m-button--is-icon{padding-left:var(--spacing-sm);padding-right:var(--spacing-sm)}.m-rich-text a{text-decoration-line:underline;transition-duration:.15s;transition-property:color,background-color,border-color,text-decoration-color,fill,stroke;transition-timing-function:cubic-bezier(.4,0,.2,1)}.m-rich-text a:hover{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}.m-rich-text ul{list-style-position:inside;list-style-type:disc;text-align:left}.m-rich-text ul li{margin-left:1.6em;text-indent:-1.35em}.m-rich-text ol{list-style-position:inside;list-style-type:decimal;text-align:left}@media screen and (max-width:768px){.m-rich-text ol li{margin-left:1.25em;text-indent:-1.22em}}.m-h1{font-size:var(--h1-sm-size);line-height:var(--h1-sm-line-height)}@media (min-width:768px){.m-h1{font-size:var(--h1-md-size);line-height:var(--h1-md-line-height)}}@media (min-width:1024px){.m-h1{font-size:var(--h1-lg-size);line-height:var(--h1-lg-line-height)}}.m-h2{font-size:var(--h2-sm-size);line-height:var(--h2-sm-line-height)}@media (min-width:768px){.m-h2{font-size:var(--h2-md-size);line-height:var(--h2-md-line-height)}}@media (min-width:1024px){.m-h2{font-size:var(--h2-lg-size);line-height:var(--h2-lg-line-height)}}.m-h3{font-size:var(--h3-sm-size);line-height:var(--h3-sm-line-height)}@media (min-width:768px){.m-h3{font-size:var(--h3-md-size);line-height:var(--h3-md-line-height)}}@media (min-width:1024px){.m-h3{font-size:var(--h3-lg-size);line-height:var(--h3-lg-line-height)}}.m-h4{font-size:var(--h4-sm-size);line-height:var(--h4-sm-line-height)}@media (min-width:768px){.m-h4{font-size:var(--h4-md-size);line-height:var(--h4-md-line-height)}}@media (min-width:1024px){.m-h4{font-size:var(--h4-lg-size);line-height:var(--h4-lg-line-height)}}.m-h5{font-size:var(--h5-sm-size);line-height:var(--h5-sm-line-height)}@media (min-width:768px){.m-h5{font-size:var(--h5-md-size);line-height:var(--h5-md-line-height)}}@media (min-width:1024px){.m-h5{font-size:var(--h5-lg-size);line-height:var(--h5-lg-line-height)}}.m-h6{font-size:var(--h6-sm-size);line-height:var(--h6-sm-line-height)}@media (min-width:768px){.m-h6{font-size:var(--h6-md-size);line-height:var(--h6-md-line-height)}}@media (min-width:1024px){.m-h6{font-size:var(--h6-lg-size);line-height:var(--h6-lg-line-height)}}.m-tabs__header:after{bottom:-.125rem;content:"";height:.125rem;left:0;position:absolute;right:0;z-index:-1;--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtle),1);background-color:rgba(var(--color-bg-content-subtle),var(--tw-bg-opacity))}.m-icon-button{align-items:center;display:inline-flex;font-size:1rem;font-weight:400;gap:.5rem;justify-content:center;line-height:1.5rem;padding:.5rem;transition-duration:.1s;transition-timing-function:cubic-bezier(0,0,.2,1);white-space:nowrap;width:-moz-fit-content;width:fit-content}.m-icon-button:hover{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.m-icon-button:active{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.m-icon-button--disabled{color:rgba(var(--color-black),.5);pointer-events:none}.m-icon-button.m-icon-button--link{padding:0}.m-icon-button a{align-items:center;display:flex;justify-content:center;padding:.5rem}.m-card:hover .image-container{--tw-scale-x:1.1;--tw-scale-y:1.1;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(1.1) scaleY(1.1);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.m-card .image-container{transition-duration:.2s;transition-property:all;transition-timing-function:cubic-bezier(.4,0,.2,1)}.m-tabs__tab.m-button{align-items:center;display:flex;font-size:.875rem;font-weight:400;line-height:1.25rem;outline:2px solid transparent;outline-offset:2px;position:relative;transition-duration:.1s;transition-timing-function:cubic-bezier(0,0,.2,1);width:-moz-fit-content;width:fit-content}:where([data-headlessui-focus-visible]) .m-tabs__tab.m-button:focus{outline-color:rgba(var(--color-border-brand),1)}.m-tabs__tab.m-button:after{bottom:-.125rem;content:"";height:.125rem;left:0;position:absolute;right:0;--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity));opacity:0;transition-duration:.15s;transition-timing-function:cubic-bezier(0,0,.2,1)}.m-tabs__tab.m-button.m-button--active{--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}.m-tabs__tab.m-button.m-button--active:after{--tw-bg-opacity:1;background-color:rgba(var(--color-brand-bold),1);background-color:rgba(var(--color-brand-bold),var(--tw-bg-opacity));opacity:1}.m-checkbox__control:focus-visible{outline:max(1px,.1em) solid rgba(var(--color-brand-default));outline-offset:max(2px,.15em)}.m-checkbox__control:checked:before{--tw-scale-x:1;--tw-scale-y:1;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(1) scaleY(1);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.m-checkbox__control:before{background-color:CanvasText;clip-path:polygon(16% 55%,24% 47%,38% 60%,73% 25%,81% 33%,38% 75%);content:"";height:1.2em;width:1.2em;--tw-scale-x:0;--tw-scale-y:0;background-color:currentColor;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(0) scaleY(0);transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.m-search-select__select[data-v-8ebcb524]{border-bottom-left-radius:.25rem;border-top-left-radius:.25rem}.m-search-select__select[data-v-8ebcb524] button{margin-bottom:0;--tw-bg-opacity:1;background-color:rgba(var(--color-surface-selected),1);background-color:rgba(var(--color-surface-selected),var(--tw-bg-opacity));--tw-text-opacity:1;color:rgba(var(--color-text-brand-bold),1);color:rgba(var(--color-text-brand-bold),var(--tw-text-opacity))}@media (min-width:1024px){.m-search-select__select[data-v-8ebcb524] button{border-bottom-right-radius:0;border-top-right-radius:0}.m-search-select__input[data-v-8ebcb524] .common-field__input{border-bottom-left-radius:0;border-left-width:0;border-top-left-radius:0}}.m-range-slider--disabled .m-range-slider__base{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-subtle),1);background-color:rgba(var(--color-bg-content-subtle),var(--tw-bg-opacity))}.m-range-slider--disabled .m-range-slider__connect,.m-range-slider--disabled .m-range-slider__handle{--tw-bg-opacity:1;background-color:rgba(var(--color-bg-content-default),1);background-color:rgba(var(--color-bg-content-default),var(--tw-bg-opacity))}.m-input__done-icon,.m-input__reset-button{display:none}.m-input__left-icon,.m-input__right-icon{--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}.m-input--filled:not(.m-input--filled.common-field--error):not(:focus-within) .m-input__done-icon{display:flex}.m-input--filled:focus-within .m-input__reset-button{display:flex}.m-input--filled .m-input__left-icon,.m-input--filled .m-input__right-icon{--tw-text-opacity:1;color:rgba(var(--color-text-default),1);color:rgba(var(--color-text-default),var(--tw-text-opacity))}.m-skeleton-item:after{height:100%;left:0;position:absolute;top:0;width:100%;--tw-translate-x:-100%;animation:shimmer 1.5s infinite;background-image:linear-gradient(90deg,hsla(0,0%,100%,0),hsla(0,0%,100%,.3),rgba(37,22,22,0));content:"";transform:translate(-100%,var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skew(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}@keyframes shimmer{to{transform:translate(100%)}}.vc-mui-brand{--vc-accent-50:rgba(var(--color-brand-sunken));--vc-accent-100:rgba(var(--color-brand-sunken));--vc-accent-200:rgba(var(--color-brand-subtlest));--vc-accent-300:rgba(var(--color-brand-subtle));--vc-accent-400:rgba(var(--color-brand-default));--vc-accent-500:rgba(var(--color-brand-bold));--vc-accent-600:rgba(var(--color-brand-bolder));--vc-accent-700:rgba(var(--color-brand-boldest));--vc-accent-800:rgba(var(--color-brand-strong));--vc-accent-900:rgba(var(--color-brand-stronger))}.m-date-picker-input-wrapper{display:flex;flex-direction:column;gap:.5rem;justify-content:space-between}.m-date-picker-input-wrapper__inline{align-items:center;flex-direction:row}.m-date-picker-input-wrapper__label{font-size:.75rem;line-height:1rem}.m-date-picker .vc-header{flex-grow:1;margin-bottom:.75rem;margin-top:.75rem}.m-date-picker .vc-title:focus{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.m-date-picker .vc-title:focus-visible{--tw-ring-offset-width:2px;--tw-ring-offset-color:rgba(var(--color-brand-bold),1)}.m-date-picker .vc-arrow{border-style:solid;border-width:1px;--tw-border-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-border-opacity))}.m-date-picker .vc-pane{min-width:21.875rem}.m-date-picker .vc-popover-content{border-width:0}.m-date-picker .vc-popover-content .vc-nav-popover-container{min-width:13rem}.m-table--fixed-header th{position:sticky;top:0}.m-table--striped tr:nth-child(2n){--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.m-table--border-bottom tr{border-bottom-width:1px;--tw-border-opacity:1;border-bottom-color:rgba(var(--color-border-bold),var(--tw-border-opacity))}.m-table--hover-bg tr:hover{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity))}.m-table th{--tw-bg-opacity:1;background-color:rgba(var(--color-surface-default),1);background-color:rgba(var(--color-surface-default),var(--tw-bg-opacity));font-size:.75rem;font-weight:400;line-height:1rem;--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity));padding:.75rem 1rem}.m-table td{padding:.5rem 1rem}@media (min-width:1280px){.m-table td{padding-bottom:1rem;padding-top:1rem}}.m-container{--container-max-width:90rem;--container-ideal-width:94vw;max-width:90rem;max-width:var(--container-max-width);min-width:16rem;width:94vw;width:var(--container-ideal-width);width:clamp(16rem,94vw,90rem);width:clamp(16rem,var(--container-ideal-width),var(--container-max-width))}@media screen and (min-width:768px){.m-container{--container-ideal-width:92.5vw}}.m-container--percentages{--container-ideal-width:94%;min-width:10rem;width:clamp(10rem,94%,var(--container-max-width));width:clamp(10rem,var(--container-ideal-width),var(--container-max-width))}@media screen and (min-width:768px){.m-container--percentages{--container-ideal-width:92.5%}}.m-calendar{border-style:none}.m-calendar .vc-header{flex-grow:1;margin-bottom:.75rem;margin-top:.75rem}.m-calendar .vc-title:focus{--tw-ring-offset-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color);--tw-ring-shadow:var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color);box-shadow:var(--tw-ring-inset) 0 0 0 var(--tw-ring-offset-width) var(--tw-ring-offset-color),var(--tw-ring-inset) 0 0 0 calc(2px + var(--tw-ring-offset-width)) var(--tw-ring-color),0 0 #0000;box-shadow:var(--tw-ring-offset-shadow),var(--tw-ring-shadow),var(--tw-shadow,0 0 #0000)}.m-calendar .vc-title:focus-visible{--tw-ring-offset-width:2px;--tw-ring-offset-color:rgba(var(--color-brand-bold),1)}.m-calendar .vc-arrow{border-style:solid;border-width:1px;--tw-border-opacity:1;border-color:rgba(var(--color-border-default),var(--tw-border-opacity));padding:.75rem}.m-calendar .vc-arrows-container{padding-left:0;padding-right:0}.m-calendar .vc-pane,.m-calendar .vc-popover-content{min-width:350px}.vc-base-icon{display:inline-block;stroke:currentColor;stroke-width:2;fill:none}.vc-header{display:grid;grid-gap:4px;align-items:center;height:30px;margin-top:10px;padding-left:10px;padding-right:10px}.vc-header.is-lg{font-size:18px;font-size:var(--vc-text-lg)}.vc-header.is-xl{font-size:20px;font-size:var(--vc-text-xl)}.vc-header.is-2xl{font-size:24px;font-size:var(--vc-text-2xl)}.vc-header .vc-next,.vc-header .vc-prev,.vc-header .vc-title{align-items:center;border:0;border-radius:.25rem;border-radius:var(--vc-rounded);cursor:pointer;display:flex;grid-row:1;pointer-events:auto;-webkit-user-select:none;-moz-user-select:none;user-select:none}.vc-header .vc-title{color:var(--vc-header-title-color);font-weight:600;font-weight:var(--vc-font-semibold);grid-column:title;line-height:30px;margin:0;padding:0 8px;white-space:nowrap}.vc-header .vc-title:hover{opacity:.75}.vc-header .vc-arrow{align-items:center;color:var(--vc-header-arrow-color);display:flex;height:30px;justify-content:center;margin:0;padding:0;width:28px}.vc-header .vc-arrow:hover{background:var(--vc-header-arrow-hover-bg)}.vc-header .vc-arrow:disabled{opacity:.25;pointer-events:none}.vc-header .vc-prev{grid-column:prev}.vc-header .vc-next{grid-column:next}.vc-day{min-height:32px;position:relative;z-index:1}.vc-monthly .is-not-in-month *{opacity:0;pointer-events:none}.vc-day-layer{bottom:0;left:0;pointer-events:none;position:absolute;right:0;top:0}.vc-day-box-center-center{align-items:center;display:flex;justify-content:center;transform-origin:50% 50%}.vc-day-box-left-center{align-items:center;display:flex;justify-content:flex-start;transform-origin:0 50%}.vc-day-box-right-center{align-items:center;display:flex;justify-content:flex-end;transform-origin:100% 50%}.vc-day-box-center-bottom{align-items:flex-end;display:flex;justify-content:center}.vc-day-content{align-items:center;border-radius:9999px;border-radius:var(--vc-rounded-full);cursor:pointer;display:flex;font-size:14px;font-size:var(--vc-text-sm);font-weight:500;font-weight:var(--vc-font-medium);height:28px;justify-content:center;line-height:28px;-webkit-user-select:none;-moz-user-select:none;user-select:none;width:28px}.vc-day-content:hover{background-color:var(--vc-day-content-hover-bg)}.vc-day-content.vc-disabled{color:var(--vc-day-content-disabled-color)}.vc-content:not(.vc-base){color:var(--vc-content-color);font-weight:700;font-weight:var(--vc-font-bold)}.vc-highlights{overflow:hidden;pointer-events:none;z-index:-1}.vc-highlight{height:28px;width:28px}.vc-highlight.vc-highlight-base-start{border-radius:0!important;border-right-width:0!important;width:50%!important}.vc-highlight.vc-highlight-base-end{border-left-width:0!important;border-radius:0!important;width:50%!important}.vc-highlight.vc-highlight-base-middle{border-left-width:0!important;border-radius:0!important;border-right-width:0!important;margin:0 -1px;width:100%}.vc-highlight-bg-none,.vc-highlight-bg-outline{background-color:var(--vc-highlight-outline-bg);border:2px solid;border-color:var(--vc-highlight-outline-border);border-radius:9999px;border-radius:var(--vc-rounded-full)}.vc-highlight-bg-light{background-color:var(--vc-highlight-light-bg)}.vc-highlight-bg-light,.vc-highlight-bg-solid{border-radius:9999px;border-radius:var(--vc-rounded-full)}.vc-highlight-bg-solid{background-color:var(--vc-highlight-solid-bg)}.vc-highlight-content-none,.vc-highlight-content-outline{color:var(--vc-highlight-outline-content-color);font-weight:700;font-weight:var(--vc-font-bold)}.vc-highlight-content-light{color:var(--vc-highlight-light-content-color);font-weight:700;font-weight:var(--vc-font-bold)}.vc-highlight-content-solid{color:var(--vc-highlight-solid-content-color);font-weight:700;font-weight:var(--vc-font-bold)}.vc-dots{align-items:center;display:flex;justify-content:center}.vc-dot{border-radius:9999px;height:5px;transition:all .13s ease-in;transition:var(--vc-day-content-transition);width:5px}.vc-dot:not(:last-child){margin-right:3px}.vc-bars{align-items:center;display:flex;justify-content:flex-start;width:75%}.vc-bar{flex-grow:1;height:3px;transition:all .13s ease-in;transition:var(--vc-day-content-transition)}.vc-dot{background-color:var(--vc-dot-bg)}.vc-bar{background-color:var(--vc-bar-bg)}.vc-pane{min-width:250px}.vc-weeknumber{align-items:center;display:flex;justify-content:center;position:absolute}.vc-weeknumber.is-left{left:-26px;left:calc(var(--vc-weeknumber-offset-inside)*-1)}.vc-weeknumber.is-right{right:-26px;right:calc(var(--vc-weeknumber-offset-inside)*-1)}.vc-weeknumber.is-left-outside{left:-34px;left:calc(var(--vc-weeknumber-offset-outside)*-1)}.vc-weeknumber.is-right-outside{right:-34px;right:calc(var(--vc-weeknumber-offset-outside)*-1)}.vc-weeknumber-content{align-items:center;color:var(--vc-weeknumber-color);display:flex;font-size:12px;font-size:var(--vc-text-xs);font-style:italic;font-weight:500;font-weight:var(--vc-font-medium);height:28px;justify-content:center;margin-top:2px;-webkit-user-select:none;-moz-user-select:none;user-select:none;width:28px}.vc-weeks{position:relative;-webkit-overflow-scrolling:touch;min-width:232px;padding:6px}.vc-weeks.vc-show-weeknumbers-left{margin-left:26px;margin-left:var(--vc-weeknumber-offset-inside)}.vc-weeks.vc-show-weeknumbers-right{margin-right:26px;margin-right:var(--vc-weeknumber-offset-inside)}.vc-weekday{color:var(--vc-weekday-color);cursor:default;font-size:14px;font-size:var(--vc-text-sm);font-weight:700;font-weight:var(--vc-font-bold);line-height:14px;padding-bottom:8px;padding-top:4px;text-align:center;-webkit-user-select:none;-moz-user-select:none;user-select:none}.vc-week,.vc-weekdays{display:grid;grid-template-columns:repeat(7,1fr);position:relative}.vc-popover-content-wrapper{--popover-horizontal-content-offset:8px;--popover-vertical-content-offset:10px;--popover-caret-horizontal-offset:18px;--popover-caret-vertical-offset:8px;display:block;outline:none;position:absolute;z-index:10}.vc-popover-content-wrapper:not(.is-interactive){pointer-events:none}.vc-popover-content{background-color:var(--vc-popover-content-bg);border:1px solid;border-color:var(--vc-popover-content-border);border-radius:.5rem;border-radius:var(--vc-rounded-lg);box-shadow:0 10px 15px -3px rgba(0,0,0,.1),0 4px 6px -2px rgba(0,0,0,.05);box-shadow:var(--vc-shadow-lg);color:var(--vc-popover-content-color);font-weight:500;font-weight:var(--vc-font-medium);outline:none;padding:4px;position:relative;z-index:10}.vc-popover-content.direction-bottom{margin-top:var(--popover-vertical-content-offset)}.vc-popover-content.direction-top{margin-bottom:var(--popover-vertical-content-offset)}.vc-popover-content.direction-left{margin-right:var(--popover-horizontal-content-offset)}.vc-popover-content.direction-right{margin-left:var(--popover-horizontal-content-offset)}.vc-popover-caret{background-color:inherit;border-left:inherit;border-top:inherit;content:"";display:block;height:12px;position:absolute;width:12px;z-index:-1}.vc-popover-caret.direction-bottom{top:0}.vc-popover-caret.direction-bottom.align-left{transform:translateY(-50%) rotate(45deg)}.vc-popover-caret.direction-bottom.align-center{transform:translate(-50%) translateY(-50%) rotate(45deg)}.vc-popover-caret.direction-bottom.align-right{transform:translateY(-50%) rotate(45deg)}.vc-popover-caret.direction-top{top:100%}.vc-popover-caret.direction-top.align-left{transform:translateY(-50%) rotate(-135deg)}.vc-popover-caret.direction-top.align-center{transform:translate(-50%) translateY(-50%) rotate(-135deg)}.vc-popover-caret.direction-top.align-right{transform:translateY(-50%) rotate(-135deg)}.vc-popover-caret.direction-left{left:100%}.vc-popover-caret.direction-left.align-top{transform:translate(-50%) rotate(135deg)}.vc-popover-caret.direction-left.align-middle{transform:translateY(-50%) translate(-50%) rotate(135deg)}.vc-popover-caret.direction-left.align-bottom{transform:translate(-50%) rotate(135deg)}.vc-popover-caret.direction-right{left:0}.vc-popover-caret.direction-right.align-top{transform:translate(-50%) rotate(-45deg)}.vc-popover-caret.direction-right.align-middle{transform:translateY(-50%) translate(-50%) rotate(-45deg)}.vc-popover-caret.direction-right.align-bottom{transform:translate(-50%) rotate(-45deg)}.vc-popover-caret.align-left{left:var(--popover-caret-horizontal-offset)}.vc-popover-caret.align-center{left:50%}.vc-popover-caret.align-right{right:var(--popover-caret-horizontal-offset)}.vc-popover-caret.align-top{top:var(--popover-caret-vertical-offset)}.vc-popover-caret.align-middle{top:50%}.vc-popover-caret.align-bottom{bottom:var(--popover-caret-vertical-offset)}.vc-nav-header{display:flex;justify-content:space-between}.vc-nav-arrow,.vc-nav-item,.vc-nav-title{border:0;border-radius:.25rem;border-radius:var(--vc-rounded);cursor:pointer;font-size:14px;font-size:var(--vc-text-sm);margin:0;-webkit-user-select:none;-moz-user-select:none;user-select:none;white-space:nowrap}.vc-nav-arrow:hover,.vc-nav-item:hover,.vc-nav-title:hover{background-color:var(--vc-nav-hover-bg)}.vc-nav-arrow:disabled,.vc-nav-item:disabled,.vc-nav-title:disabled{opacity:.25;pointer-events:none}.vc-nav-title{color:var(--vc-nav-title-color);font-weight:700;font-weight:var(--vc-font-bold);height:30px;line-height:1.375;line-height:var(--vc-leading-snug);padding:0 6px}.vc-nav-arrow{align-items:center;color:var(--vc-header-arrow-color);display:flex;height:30px;justify-content:center;padding:0;width:26px}.vc-nav-items{display:grid;grid-template-columns:repeat(3,1fr);grid-row-gap:2px;grid-column-gap:5px;margin-top:2px}.vc-nav-item{font-weight:600;font-weight:var(--vc-font-semibold);line-height:1.375;line-height:var(--vc-leading-snug);padding:6px 0;text-align:center;width:48px}.vc-nav-item.is-active{background-color:var(--vc-nav-item-active-bg);color:var(--vc-nav-item-active-color);font-weight:700;font-weight:var(--vc-font-bold)}.vc-nav-item.is-active:not(:focus){box-shadow:var(--vc-nav-item-active-box-shadow)}.vc-nav-item.is-current{color:var(--vc-nav-item-current-color)}.vc-day-popover-row{align-items:center;display:flex;transition:all .13s ease-in;transition:var(--vc-day-content-transition)}.vc-day-popover-row-indicator{align-items:center;display:flex;flex-grow:0;justify-content:center;width:15px}.vc-day-popover-row-indicator span{transition:all .13s ease-in;transition:var(--vc-day-content-transition)}.vc-day-popover-row-label{align-items:center;display:flex;flex-grow:1;flex-wrap:none;font-size:12px;font-size:var(--vc-text-xs);line-height:1.5;line-height:var(--vc-leading-normal);margin-left:4px;margin-right:4px;width:-moz-max-content;width:max-content}.vc-day-popover-row-highlight{border-radius:3px;height:5px;width:8px}.vc-day-popover-row-bar{height:3px;width:10px}.vc-pane-container{position:relative;width:100%}.vc-pane-container.in-transition{overflow:hidden}.vc-pane-layout{display:grid}.vc-pane-header-wrapper{pointer-events:none;position:absolute;top:0;width:100%}.vc-day-popover-container{font-size:12px;font-size:var(--vc-text-xs);font-weight:500;font-weight:var(--vc-font-medium)}.vc-day-popover-header{color:var(--vc-day-popover-header-color);font-size:12px;font-size:var(--vc-text-xs);font-weight:600;font-weight:var(--vc-font-semibold);text-align:center}.vc-base-select{position:relative}.vc-base-select select{-webkit-appearance:none;-moz-appearance:none;appearance:none;background-color:transparent;background-image:none;border-radius:.25rem;border-radius:var(--vc-rounded);color:var(--vc-select-color);cursor:pointer;display:block;font-size:16px;font-size:var(--vc-text-base);font-weight:500;font-weight:var(--vc-font-medium);height:30px;line-height:var(--leading-none);margin:0;padding:0 4px;text-align:center;text-indent:0;width:-moz-max-content;width:max-content}.vc-base-select select:hover{background-color:var(--vc-select-hover-bg)}.vc-base-select select.vc-has-icon{padding:0 24px 0 10px}.vc-base-select select.vc-small{font-size:14px;font-size:var(--vc-text-sm)}.vc-base-select select.vc-small.vc-has-icon{padding:0 20px 0 8}.vc-base-select select.vc-align-left{text-align:left}.vc-base-select select.vc-align-right{text-align:right}.vc-base-select .vc-base-icon{opacity:.6;pointer-events:none;position:absolute;right:4px;top:6px}.vc-time-picker{align-items:center;display:flex;flex-direction:column;padding:8px 4px}.vc-time-picker.vc-invalid{opacity:.5;pointer-events:none}.vc-time-picker.vc-attached{border-top:1px solid var(--vc-time-picker-border)}.vc-time-picker>*+*{margin-top:4px}.vc-time-header{align-items:center;display:flex;font-size:14px;font-size:var(--vc-text-sm);font-weight:600;font-weight:var(--vc-font-semibold);line-height:21px;margin-top:-4px;padding-left:4px;padding-right:4px;text-transform:uppercase}.vc-time-select-group{align-items:center;background:var(--vc-time-select-group-bg);border:1px solid var(--vc-time-select-group-border);border-radius:.375rem;border-radius:var(--vc-rounded-md);display:inline-flex;padding:0 4px}.vc-time-select-group .vc-base-icon{color:var(--vc-time-select-group-icon-color);margin-right:4px}.vc-time-weekday{color:var(--vc-time-weekday-color);letter-spacing:var(--tracking-wide)}.vc-time-month{color:var(--vc-time-month-color);margin-left:8px}.vc-time-day{color:var(--vc-time-day-color);margin-left:4px}.vc-time-year{color:var(--vc-time-year-color);margin-left:8px}.vc-time-colon{margin:0 1px 2px 2px}.vc-time-decimal{margin:0 0 0 1px}.vc-none-enter-active,.vc-none-leave-active{transition-duration:0s}.vc-fade-enter-active,.vc-fade-leave-active,.vc-slide-down-enter-active,.vc-slide-down-leave-active,.vc-slide-fade-enter-active,.vc-slide-fade-leave-active,.vc-slide-left-enter-active,.vc-slide-left-leave-active,.vc-slide-right-enter-active,.vc-slide-right-leave-active,.vc-slide-up-enter-active,.vc-slide-up-leave-active{backface-visibility:hidden;pointer-events:none;transition:transform .15s ease,opacity .15s ease;transition:transform var(--vc-slide-duration) var(--vc-slide-timing),opacity var(--vc-slide-duration) var(--vc-slide-timing)}.vc-fade-leave-active,.vc-none-leave-active,.vc-slide-down-leave-active,.vc-slide-left-leave-active,.vc-slide-right-leave-active,.vc-slide-up-leave-active{position:absolute!important;width:100%}.vc-fade-enter-from,.vc-fade-leave-to,.vc-none-enter-from,.vc-none-leave-to,.vc-slide-down-enter-from,.vc-slide-down-leave-to,.vc-slide-fade-enter-from,.vc-slide-fade-leave-to,.vc-slide-left-enter-from,.vc-slide-left-leave-to,.vc-slide-right-enter-from,.vc-slide-right-leave-to,.vc-slide-up-enter-from,.vc-slide-up-leave-to{opacity:0}.vc-slide-fade-enter-from.direction-left,.vc-slide-fade-leave-to.direction-left,.vc-slide-left-enter-from,.vc-slide-right-leave-to{transform:translate(22px);transform:translate(var(--vc-slide-translate))}.vc-slide-fade-enter-from.direction-right,.vc-slide-fade-leave-to.direction-right,.vc-slide-left-leave-to,.vc-slide-right-enter-from{transform:translate(-22px);transform:translate(calc(var(--vc-slide-translate)*-1))}.vc-slide-down-leave-to,.vc-slide-fade-enter-from.direction-top,.vc-slide-fade-leave-to.direction-top,.vc-slide-up-enter-from{transform:translateY(22px);transform:translateY(var(--vc-slide-translate))}.vc-slide-down-enter-from,.vc-slide-fade-enter-from.direction-bottom,.vc-slide-fade-leave-to.direction-bottom,.vc-slide-up-leave-to{transform:translateY(-22px);transform:translateY(calc(var(--vc-slide-translate)*-1))}:root{--vc-white:#fff;--vc-black:#000;--vc-gray-50:#f8fafc;--vc-gray-100:#f1f5f9;--vc-gray-200:#e2e8f0;--vc-gray-300:#cbd5e1;--vc-gray-400:#94a3b8;--vc-gray-500:#64748b;--vc-gray-600:#475569;--vc-gray-700:#334155;--vc-gray-800:#1e293b;--vc-gray-900:#0f172a;--vc-font-family:BlinkMacSystemFont,-apple-system,"Segoe UI","Roboto","Oxygen","Ubuntu","Cantarell","Fira Sans","Droid Sans","Helvetica Neue","Helvetica","Arial",sans-serif;--vc-font-normal:400;--vc-font-medium:500;--vc-font-semibold:600;--vc-font-bold:700;--vc-text-2xs:10px;--vc-text-xs:12px;--vc-text-sm:14px;--vc-text-base:16px;--vc-text-lg:18px;--vc-text-xl:20px;--vc-text-2xl:24px;--vc-leading-none:1;--vc-leading-tight:1.25;--vc-leading-snug:1.375;--vc-leading-normal:1.5;--vc-rounded:.25rem;--vc-rounded-md:.375rem;--vc-rounded-lg:.5rem;--vc-rounded-full:9999px;--vc-shadow:0 1px 3px 0 rgba(0,0,0,.1),0 1px 2px 0 rgba(0,0,0,.06);--vc-shadow-lg:0 10px 15px -3px rgba(0,0,0,.1),0 4px 6px -2px rgba(0,0,0,.05);--vc-shadow-inner:inset 0 2px 4px 0 rgba(0,0,0,.06);--vc-slide-translate:22px;--vc-slide-duration:.15s;--vc-slide-timing:ease;--vc-day-content-transition:all .13s ease-in;--vc-weeknumber-offset-inside:26px;--vc-weeknumber-offset-outside:34px}.vc-gray{--vc-accent-50:var(--vc-gray-50);--vc-accent-100:var(--vc-gray-100);--vc-accent-200:var(--vc-gray-200);--vc-accent-300:var(--vc-gray-300);--vc-accent-400:var(--vc-gray-400);--vc-accent-500:var(--vc-gray-500);--vc-accent-600:var(--vc-gray-600);--vc-accent-700:var(--vc-gray-700);--vc-accent-800:var(--vc-gray-800);--vc-accent-900:var(--vc-gray-900)}.vc-red{--vc-accent-50:#fef2f2;--vc-accent-100:#fee2e2;--vc-accent-200:#fecaca;--vc-accent-300:#fca5a5;--vc-accent-400:#f87171;--vc-accent-500:#ef4444;--vc-accent-600:#dc2626;--vc-accent-700:#b91c1c;--vc-accent-800:#991b1b;--vc-accent-900:#7f1d1d}.vc-orange{--vc-accent-50:#fff7ed;--vc-accent-100:#ffedd5;--vc-accent-200:#fed7aa;--vc-accent-300:#fdba74;--vc-accent-400:#fb923c;--vc-accent-500:#f97316;--vc-accent-600:#ea580c;--vc-accent-700:#c2410c;--vc-accent-800:#9a3412;--vc-accent-900:#7c2d12}.vc-yellow{--vc-accent-50:#fefce8;--vc-accent-100:#fef9c3;--vc-accent-200:#fef08a;--vc-accent-300:#fde047;--vc-accent-400:#facc15;--vc-accent-500:#eab308;--vc-accent-600:#ca8a04;--vc-accent-700:#a16207;--vc-accent-800:#854d0e;--vc-accent-900:#713f12}.vc-green{--vc-accent-50:#f0fdf4;--vc-accent-100:#dcfce7;--vc-accent-200:#bbf7d0;--vc-accent-300:#86efac;--vc-accent-400:#4ade80;--vc-accent-500:#22c55e;--vc-accent-600:#16a34a;--vc-accent-700:#15803d;--vc-accent-800:#166534;--vc-accent-900:#14532d}.vc-teal{--vc-accent-50:#f0fdfa;--vc-accent-100:#ccfbf1;--vc-accent-200:#99f6e4;--vc-accent-300:#5eead4;--vc-accent-400:#2dd4bf;--vc-accent-500:#14b8a6;--vc-accent-600:#0d9488;--vc-accent-700:#0f766e;--vc-accent-800:#115e59;--vc-accent-900:#134e4a}.vc-blue{--vc-accent-50:#eff6ff;--vc-accent-100:#dbeafe;--vc-accent-200:#bfdbfe;--vc-accent-300:#93c5fd;--vc-accent-400:#60a5fa;--vc-accent-500:#3b82f6;--vc-accent-600:#2563eb;--vc-accent-700:#1d4ed8;--vc-accent-800:#1e40af;--vc-accent-900:#1e3a8a}.vc-indigo{--vc-accent-50:#eef2ff;--vc-accent-100:#e0e7ff;--vc-accent-200:#c7d2fe;--vc-accent-300:#a5b4fc;--vc-accent-400:#818cf8;--vc-accent-500:#6366f1;--vc-accent-600:#4f46e5;--vc-accent-700:#4338ca;--vc-accent-800:#3730a3;--vc-accent-900:#312e81}.vc-purple{--vc-accent-50:#faf5ff;--vc-accent-100:#f3e8ff;--vc-accent-200:#e9d5ff;--vc-accent-300:#d8b4fe;--vc-accent-400:#c084fc;--vc-accent-500:#a855f7;--vc-accent-600:#9333ea;--vc-accent-700:#7e22ce;--vc-accent-800:#6b21a8;--vc-accent-900:#581c87}.vc-pink{--vc-accent-50:#fdf2f8;--vc-accent-100:#fce7f3;--vc-accent-200:#fbcfe8;--vc-accent-300:#f9a8d4;--vc-accent-400:#f472b6;--vc-accent-500:#ec4899;--vc-accent-600:#db2777;--vc-accent-700:#be185d;--vc-accent-800:#9d174d;--vc-accent-900:#831843}.vc-focus:focus-within{box-shadow:var(--vc-focus-ring);outline:0}.vc-light{--vc-color:var(--vc-gray-900);--vc-bg:var(--vc-white);--vc-border:var(--vc-gray-300);--vc-hover-bg:rgba(204,214,224,.3);--vc-focus-ring:0 0 0 2px rgba(59,131,246,.4);--vc-header-arrow-color:var(--vc-gray-500);--vc-header-arrow-hover-bg:var(--vc-gray-200);--vc-header-title-color:var(--vc-gray-900);--vc-weekday-color:var(--vc-gray-500);--vc-weeknumber-color:var(--vc-gray-400);--vc-nav-hover-bg:var(--vc-gray-200);--vc-nav-title-color:var(--vc-gray-900);--vc-nav-item-hover-box-shadow:none;--vc-nav-item-active-color:var(--vc-white);--vc-nav-item-active-bg:var(--vc-accent-500);--vc-nav-item-active-box-shadow:var(--vc-shadow);--vc-nav-item-current-color:var(--vc-accent-600);--vc-day-popover-container-color:var(--vc-white);--vc-day-popover-container-bg:var(--vc-gray-800);--vc-day-popover-container-border:var(--vc-gray-700);--vc-day-popover-header-color:var(--vc-gray-700);--vc-popover-content-color:var(--vc-gray-900);--vc-popover-content-bg:var(--vc-gray-50);--vc-popover-content-border:var(--vc-gray-300);--vc-time-picker-border:var(--vc-gray-300);--vc-time-weekday-color:var(--vc-gray-700);--vc-time-month-color:var(--vc-accent-600);--vc-time-day-color:var(--vc-accent-600);--vc-time-year-color:var(--vc-gray-500);--vc-time-select-group-bg:var(--vc-gray-50);--vc-time-select-group-border:var(--vc-gray-300);--vc-time-select-group-icon-color:var(--vc-accent-500);--vc-select-color:var(--vc-gray-900);--vc-select-bg:var(--vg-gray-50);--vc-select-hover-bg:var(--vc-gray-100);--vc-select-border:var(--vc-gray-300);--vc-day-content-hover-bg:var(--vc-hover-bg);--vc-day-content-disabled-color:var(--vc-gray-400)}.vc-light .vc-attr,.vc-light.vc-attr{--vc-content-color:var(--vc-accent-600);--vc-highlight-outline-bg:var(--vc-white);--vc-highlight-outline-border:var(--vc-accent-600);--vc-highlight-outline-content-color:var(--vc-accent-700);--vc-highlight-light-bg:var(--vc-accent-200);--vc-highlight-light-content-color:var(--vc-accent-900);--vc-highlight-solid-bg:var(--vc-accent-600);--vc-highlight-solid-content-color:var(--vc-white);--vc-dot-bg:var(--vc-accent-600);--vc-bar-bg:var(--vc-accent-600)}.vc-dark{--vc-color:var(--vc-white);--vc-bg:var(--vc-gray-900);--vc-border:var(--vc-gray-700);--vc-hover-bg:rgba(114,129,151,.3);--vc-focus-ring:0 0 0 2px rgba(59,130,246,.7);--vc-header-arrow-color:var(--vc-gray-300);--vc-header-arrow-hover-bg:var(--vc-gray-800);--vc-header-title-color:var(--vc-gray-100);--vc-weekday-color:var(--vc-accent-200);--vc-weeknumber-color:var(--vc-gray-500);--vc-nav-hover-bg:var(--vc-gray-700);--vc-nav-title-color:var(--vc-gray-100);--vc-nav-item-hover-box-shadow:none;--vc-nav-item-active-color:var(--vc-white);--vc-nav-item-active-bg:var(--vc-accent-500);--vc-nav-item-active-box-shadow:none;--vc-nav-item-current-color:var(--vc-accent-400);--vc-day-popover-container-color:var(--vc-gray-800);--vc-day-popover-container-bg:var(--vc-white);--vc-day-popover-container-border:var(--vc-gray-100);--vc-day-popover-header-color:var(--vc-gray-300);--vc-popover-content-color:var(--vc-white);--vc-popover-content-bg:var(--vc-gray-800);--vc-popover-content-border:var(--vc-gray-700);--vc-time-picker-border:var(--vc-gray-700);--vc-time-weekday-color:var(--vc-gray-400);--vc-time-month-color:var(--vc-accent-400);--vc-time-day-color:var(--vc-accent-400);--vc-time-year-color:var(--vc-gray-500);--vc-time-select-group-bg:var(--vc-gray-700);--vc-time-select-group-border:var(--vc-gray-500);--vc-time-select-group-icon-color:var(--vc-accent-400);--vc-select-color:var(--vc-gray-200);--vc-select-bg:var(--vc-gray-700);--vc-select-hover-bg:var(--vc-gray-600);--vc-select-border:var(--vc-gray-500);--vc-day-content-hover-bg:var(--vc-hover-bg);--vc-day-content-disabled-color:var(--vc-gray-600)}.vc-dark .vc-attr,.vc-dark.vc-attr{--vc-content-color:var(--vc-accent-500);--vc-highlight-outline-bg:var(--vc-gray-900);--vc-highlight-outline-border:var(--vc-accent-300);--vc-highlight-outline-content-color:var(--vc-accent-200);--vc-highlight-light-bg:var(--vc-accent-800);--vc-highlight-light-content-color:var(--vc-accent-100);--vc-highlight-solid-bg:var(--vc-accent-500);--vc-highlight-solid-content-color:var(--vc-white);--vc-dot-bg:var(--vc-accent-500);--vc-bar-bg:var(--vc-accent-500)}.vc-container{background-color:var(--vc-bg);color:var(--vc-color);display:inline-flex;font-family:BlinkMacSystemFont,-apple-system,Segoe UI,Roboto,Oxygen,Ubuntu,Cantarell,Fira Sans,Droid Sans,Helvetica Neue,Helvetica,Arial,sans-serif;font-family:var(--vc-font-family);height:-moz-max-content;height:max-content;position:relative;width:-moz-max-content;width:max-content;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;-webkit-tap-highlight-color:transparent}.vc-container,.vc-container *{box-sizing:border-box}.vc-container :focus,.vc-container:focus{outline:none}.vc-container .vc-container{border:none}.vc-bordered{border:1px solid;border-color:var(--vc-border);border-radius:.5rem;border-radius:var(--vc-rounded-lg)}.vc-expanded{min-width:100%}.vc-transparent{background-color:transparent}.vc-date-picker-content{background-color:var(--vc-bg);padding:0}.vc-date-picker-content .vc-container{border:0}</style> <style>@font-face{font-family:swiper-icons;font-style:normal;font-weight:400;src:url("data:application/font-woff;charset=utf-8;base64, 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")}:root{--swiper-theme-color:#007aff}:host{display:block;margin-left:auto;margin-right:auto;position:relative;z-index:1}.swiper{display:block;list-style:none;margin-left:auto;margin-right:auto;overflow:hidden;overflow:clip;padding:0;position:relative;z-index:1}.swiper-vertical>.swiper-wrapper{flex-direction:column}.swiper-wrapper{box-sizing:content-box;display:flex;height:100%;position:relative;transition-property:transform;transition-timing-function:ease;transition-timing-function:var(--swiper-wrapper-transition-timing-function,initial);width:100%;z-index:1}.swiper-android .swiper-slide,.swiper-ios .swiper-slide,.swiper-wrapper{transform:translateZ(0)}.swiper-horizontal{touch-action:pan-y}.swiper-vertical{touch-action:pan-x}.swiper-slide{display:block;flex-shrink:0;height:100%;position:relative;transition-property:transform;width:100%}.swiper-slide-invisible-blank{visibility:hidden}.swiper-autoheight,.swiper-autoheight .swiper-slide{height:auto}.swiper-autoheight .swiper-wrapper{align-items:flex-start;transition-property:transform,height}.swiper-backface-hidden .swiper-slide{backface-visibility:hidden;transform:translateZ(0)}.swiper-3d.swiper-css-mode .swiper-wrapper{perspective:1200px}.swiper-3d .swiper-wrapper{transform-style:preserve-3d}.swiper-3d{perspective:1200px}.swiper-3d .swiper-cube-shadow,.swiper-3d .swiper-slide{transform-style:preserve-3d}.swiper-css-mode>.swiper-wrapper{overflow:auto;scrollbar-width:none;-ms-overflow-style:none}.swiper-css-mode>.swiper-wrapper::-webkit-scrollbar{display:none}.swiper-css-mode>.swiper-wrapper>.swiper-slide{scroll-snap-align:start start}.swiper-css-mode.swiper-horizontal>.swiper-wrapper{scroll-snap-type:x mandatory}.swiper-css-mode.swiper-vertical>.swiper-wrapper{scroll-snap-type:y mandatory}.swiper-css-mode.swiper-free-mode>.swiper-wrapper{scroll-snap-type:none}.swiper-css-mode.swiper-free-mode>.swiper-wrapper>.swiper-slide{scroll-snap-align:none}.swiper-css-mode.swiper-centered>.swiper-wrapper:before{content:"";flex-shrink:0;order:9999}.swiper-css-mode.swiper-centered>.swiper-wrapper>.swiper-slide{scroll-snap-align:center center;scroll-snap-stop:always}.swiper-css-mode.swiper-centered.swiper-horizontal>.swiper-wrapper>.swiper-slide:first-child{margin-inline-start:var(--swiper-centered-offset-before)}.swiper-css-mode.swiper-centered.swiper-horizontal>.swiper-wrapper:before{height:100%;min-height:1px;width:var(--swiper-centered-offset-after)}.swiper-css-mode.swiper-centered.swiper-vertical>.swiper-wrapper>.swiper-slide:first-child{margin-block-start:var(--swiper-centered-offset-before)}.swiper-css-mode.swiper-centered.swiper-vertical>.swiper-wrapper:before{height:var(--swiper-centered-offset-after);min-width:1px;width:100%}.swiper-3d .swiper-slide-shadow,.swiper-3d .swiper-slide-shadow-bottom,.swiper-3d .swiper-slide-shadow-left,.swiper-3d .swiper-slide-shadow-right,.swiper-3d .swiper-slide-shadow-top{height:100%;left:0;pointer-events:none;position:absolute;top:0;width:100%;z-index:10}.swiper-3d .swiper-slide-shadow{background:rgba(0,0,0,.15)}.swiper-3d .swiper-slide-shadow-left{background-image:linear-gradient(270deg,rgba(0,0,0,.5),transparent)}.swiper-3d .swiper-slide-shadow-right{background-image:linear-gradient(90deg,rgba(0,0,0,.5),transparent)}.swiper-3d .swiper-slide-shadow-top{background-image:linear-gradient(0deg,rgba(0,0,0,.5),transparent)}.swiper-3d .swiper-slide-shadow-bottom{background-image:linear-gradient(180deg,rgba(0,0,0,.5),transparent)}.swiper-lazy-preloader{border:4px solid #007aff;border:4px solid var(--swiper-preloader-color,var(--swiper-theme-color));border-radius:50%;border-top:4px solid transparent;box-sizing:border-box;height:42px;left:50%;margin-left:-21px;margin-top:-21px;position:absolute;top:50%;transform-origin:50%;width:42px;z-index:10}.swiper-watch-progress .swiper-slide-visible .swiper-lazy-preloader,.swiper:not(.swiper-watch-progress) .swiper-lazy-preloader{animation:swiper-preloader-spin 1s linear infinite}.swiper-lazy-preloader-white{--swiper-preloader-color:#fff}.swiper-lazy-preloader-black{--swiper-preloader-color:#000}@keyframes swiper-preloader-spin{0%{transform:rotate(0deg)}to{transform:rotate(1turn)}}</style> <style>.swiper .swiper-notification{left:0;opacity:0;pointer-events:none;position:absolute;top:0;z-index:-1000}</style> <style>.swiper-cards{overflow:visible}.swiper-cards .swiper-slide{backface-visibility:hidden;overflow:hidden;transform-origin:center bottom}</style> <style>.swiper-creative .swiper-slide{backface-visibility:hidden;overflow:hidden;transition-property:transform,opacity,height}</style> <style>.swiper-cube{overflow:visible}.swiper-cube .swiper-slide{backface-visibility:hidden;height:100%;pointer-events:none;transform-origin:0 0;visibility:hidden;width:100%;z-index:1}.swiper-cube .swiper-slide .swiper-slide{pointer-events:none}.swiper-cube.swiper-rtl .swiper-slide{transform-origin:100% 0}.swiper-cube .swiper-slide-active,.swiper-cube .swiper-slide-active .swiper-slide-active{pointer-events:auto}.swiper-cube .swiper-slide-active,.swiper-cube .swiper-slide-next,.swiper-cube .swiper-slide-prev{pointer-events:auto;visibility:visible}.swiper-cube .swiper-cube-shadow{bottom:0;height:100%;left:0;opacity:.6;position:absolute;width:100%;z-index:0}.swiper-cube .swiper-cube-shadow:before{background:#000;bottom:0;content:"";filter:blur(50px);left:0;position:absolute;right:0;top:0}.swiper-cube .swiper-slide-next+.swiper-slide{pointer-events:auto;visibility:visible}.swiper-cube .swiper-slide-shadow-cube.swiper-slide-shadow-bottom,.swiper-cube .swiper-slide-shadow-cube.swiper-slide-shadow-left,.swiper-cube .swiper-slide-shadow-cube.swiper-slide-shadow-right,.swiper-cube .swiper-slide-shadow-cube.swiper-slide-shadow-top{backface-visibility:hidden;z-index:0}</style> <style>.swiper-fade.swiper-free-mode .swiper-slide{transition-timing-function:ease-out}.swiper-fade .swiper-slide{pointer-events:none;transition-property:opacity}.swiper-fade .swiper-slide .swiper-slide{pointer-events:none}.swiper-fade .swiper-slide-active,.swiper-fade .swiper-slide-active .swiper-slide-active{pointer-events:auto}</style> <style>.swiper-flip{overflow:visible}.swiper-flip .swiper-slide{backface-visibility:hidden;pointer-events:none;z-index:1}.swiper-flip .swiper-slide .swiper-slide{pointer-events:none}.swiper-flip .swiper-slide-active,.swiper-flip .swiper-slide-active .swiper-slide-active{pointer-events:auto}.swiper-flip .swiper-slide-shadow-flip.swiper-slide-shadow-bottom,.swiper-flip .swiper-slide-shadow-flip.swiper-slide-shadow-left,.swiper-flip .swiper-slide-shadow-flip.swiper-slide-shadow-right,.swiper-flip .swiper-slide-shadow-flip.swiper-slide-shadow-top{backface-visibility:hidden;z-index:0}</style> <style>.swiper-free-mode>.swiper-wrapper{margin:0 auto;transition-timing-function:ease-out}</style> <style>.swiper-grid>.swiper-wrapper{flex-wrap:wrap}.swiper-grid-column>.swiper-wrapper{flex-direction:column;flex-wrap:wrap}</style> <style>:root{--swiper-navigation-size:44px}.swiper-button-next,.swiper-button-prev{align-items:center;color:var(--swiper-navigation-color,var(--swiper-theme-color));cursor:pointer;display:flex;height:44px;height:var(--swiper-navigation-size);justify-content:center;margin-top:-22px;margin-top:calc(0px - var(--swiper-navigation-size)/2);position:absolute;top:50%;top:var(--swiper-navigation-top-offset,50%);width:27px;width:calc(var(--swiper-navigation-size)/44*27);z-index:10}.swiper-button-next.swiper-button-disabled,.swiper-button-prev.swiper-button-disabled{cursor:auto;opacity:.35;pointer-events:none}.swiper-button-next.swiper-button-hidden,.swiper-button-prev.swiper-button-hidden{cursor:auto;opacity:0;pointer-events:none}.swiper-navigation-disabled .swiper-button-next,.swiper-navigation-disabled .swiper-button-prev{display:none!important}.swiper-button-next svg,.swiper-button-prev svg{height:100%;-o-object-fit:contain;object-fit:contain;transform-origin:center;width:100%}.swiper-rtl .swiper-button-next svg,.swiper-rtl .swiper-button-prev svg{transform:rotate(180deg)}.swiper-button-prev,.swiper-rtl .swiper-button-next{left:10px;left:var(--swiper-navigation-sides-offset,10px);right:auto}.swiper-button-lock{display:none}.swiper-button-next:after,.swiper-button-prev:after{font-family:swiper-icons;font-size:44px;font-size:var(--swiper-navigation-size);font-variant:normal;letter-spacing:0;line-height:1;text-transform:none!important}.swiper-button-prev:after,.swiper-rtl .swiper-button-next:after{content:"prev"}.swiper-button-next,.swiper-rtl .swiper-button-prev{left:auto;right:10px;right:var(--swiper-navigation-sides-offset,10px)}.swiper-button-next:after,.swiper-rtl .swiper-button-prev:after{content:"next"}</style> <style>.swiper-pagination{position:absolute;text-align:center;transform:translateZ(0);transition:opacity .3s;z-index:10}.swiper-pagination.swiper-pagination-hidden{opacity:0}.swiper-pagination-disabled>.swiper-pagination,.swiper-pagination.swiper-pagination-disabled{display:none!important}.swiper-horizontal>.swiper-pagination-bullets,.swiper-pagination-bullets.swiper-pagination-horizontal,.swiper-pagination-custom,.swiper-pagination-fraction{bottom:8px;bottom:var(--swiper-pagination-bottom,8px);left:0;top:auto;top:var(--swiper-pagination-top,auto);width:100%}.swiper-pagination-bullets-dynamic{font-size:0;overflow:hidden}.swiper-pagination-bullets-dynamic .swiper-pagination-bullet{position:relative;transform:scale(.33)}.swiper-pagination-bullets-dynamic .swiper-pagination-bullet-active,.swiper-pagination-bullets-dynamic .swiper-pagination-bullet-active-main{transform:scale(1)}.swiper-pagination-bullets-dynamic .swiper-pagination-bullet-active-prev{transform:scale(.66)}.swiper-pagination-bullets-dynamic .swiper-pagination-bullet-active-prev-prev{transform:scale(.33)}.swiper-pagination-bullets-dynamic .swiper-pagination-bullet-active-next{transform:scale(.66)}.swiper-pagination-bullets-dynamic .swiper-pagination-bullet-active-next-next{transform:scale(.33)}.swiper-pagination-bullet{background:#000;background:var(--swiper-pagination-bullet-inactive-color,#000);border-radius:50%;border-radius:var(--swiper-pagination-bullet-border-radius,50%);display:inline-block;height:8px;height:var(--swiper-pagination-bullet-height,var(--swiper-pagination-bullet-size,8px));opacity:.2;opacity:var(--swiper-pagination-bullet-inactive-opacity,.2);width:8px;width:var(--swiper-pagination-bullet-width,var(--swiper-pagination-bullet-size,8px))}button.swiper-pagination-bullet{-webkit-appearance:none;-moz-appearance:none;appearance:none;border:none;box-shadow:none;margin:0;padding:0}.swiper-pagination-clickable .swiper-pagination-bullet{cursor:pointer}.swiper-pagination-bullet:only-child{display:none!important}.swiper-pagination-bullet-active{background:var(--swiper-pagination-color,var(--swiper-theme-color));opacity:1;opacity:var(--swiper-pagination-bullet-opacity,1)}.swiper-pagination-vertical.swiper-pagination-bullets,.swiper-vertical>.swiper-pagination-bullets{left:auto;left:var(--swiper-pagination-left,auto);right:8px;right:var(--swiper-pagination-right,8px);top:50%;transform:translate3d(0,-50%,0)}.swiper-pagination-vertical.swiper-pagination-bullets .swiper-pagination-bullet,.swiper-vertical>.swiper-pagination-bullets .swiper-pagination-bullet{display:block;margin:6px 0;margin:var(--swiper-pagination-bullet-vertical-gap,6px) 0}.swiper-pagination-vertical.swiper-pagination-bullets.swiper-pagination-bullets-dynamic,.swiper-vertical>.swiper-pagination-bullets.swiper-pagination-bullets-dynamic{top:50%;transform:translateY(-50%);width:8px}.swiper-pagination-vertical.swiper-pagination-bullets.swiper-pagination-bullets-dynamic .swiper-pagination-bullet,.swiper-vertical>.swiper-pagination-bullets.swiper-pagination-bullets-dynamic .swiper-pagination-bullet{display:inline-block;transition:transform .2s,top .2s}.swiper-horizontal>.swiper-pagination-bullets .swiper-pagination-bullet,.swiper-pagination-horizontal.swiper-pagination-bullets .swiper-pagination-bullet{margin:0 4px;margin:0 var(--swiper-pagination-bullet-horizontal-gap,4px)}.swiper-horizontal>.swiper-pagination-bullets.swiper-pagination-bullets-dynamic,.swiper-pagination-horizontal.swiper-pagination-bullets.swiper-pagination-bullets-dynamic{left:50%;transform:translateX(-50%);white-space:nowrap}.swiper-horizontal>.swiper-pagination-bullets.swiper-pagination-bullets-dynamic .swiper-pagination-bullet,.swiper-pagination-horizontal.swiper-pagination-bullets.swiper-pagination-bullets-dynamic .swiper-pagination-bullet{transition:transform .2s,left .2s}.swiper-horizontal.swiper-rtl>.swiper-pagination-bullets-dynamic .swiper-pagination-bullet{transition:transform .2s,right .2s}.swiper-pagination-fraction{color:inherit;color:var(--swiper-pagination-fraction-color,inherit)}.swiper-pagination-progressbar{background:rgba(0,0,0,.25);background:var(--swiper-pagination-progressbar-bg-color,rgba(0,0,0,.25));position:absolute}.swiper-pagination-progressbar .swiper-pagination-progressbar-fill{background:var(--swiper-pagination-color,var(--swiper-theme-color));height:100%;left:0;position:absolute;top:0;transform:scale(0);transform-origin:left top;width:100%}.swiper-rtl .swiper-pagination-progressbar .swiper-pagination-progressbar-fill{transform-origin:right top}.swiper-horizontal>.swiper-pagination-progressbar,.swiper-pagination-progressbar.swiper-pagination-horizontal,.swiper-pagination-progressbar.swiper-pagination-vertical.swiper-pagination-progressbar-opposite,.swiper-vertical>.swiper-pagination-progressbar.swiper-pagination-progressbar-opposite{height:4px;height:var(--swiper-pagination-progressbar-size,4px);left:0;top:0;width:100%}.swiper-horizontal>.swiper-pagination-progressbar.swiper-pagination-progressbar-opposite,.swiper-pagination-progressbar.swiper-pagination-horizontal.swiper-pagination-progressbar-opposite,.swiper-pagination-progressbar.swiper-pagination-vertical,.swiper-vertical>.swiper-pagination-progressbar{height:100%;left:0;top:0;width:4px;width:var(--swiper-pagination-progressbar-size,4px)}.swiper-pagination-lock{display:none}</style> <style>.swiper-scrollbar{background:rgba(0,0,0,.1);background:var(--swiper-scrollbar-bg-color,rgba(0,0,0,.1));border-radius:10px;border-radius:var(--swiper-scrollbar-border-radius,10px);position:relative;touch-action:none}.swiper-scrollbar-disabled>.swiper-scrollbar,.swiper-scrollbar.swiper-scrollbar-disabled{display:none!important}.swiper-horizontal>.swiper-scrollbar,.swiper-scrollbar.swiper-scrollbar-horizontal{bottom:4px;bottom:var(--swiper-scrollbar-bottom,4px);height:4px;height:var(--swiper-scrollbar-size,4px);left:1%;left:var(--swiper-scrollbar-sides-offset,1%);position:absolute;top:auto;top:var(--swiper-scrollbar-top,auto);width:98%;width:calc(100% - var(--swiper-scrollbar-sides-offset, 1%)*2);z-index:50}.swiper-scrollbar.swiper-scrollbar-vertical,.swiper-vertical>.swiper-scrollbar{height:98%;height:calc(100% - var(--swiper-scrollbar-sides-offset, 1%)*2);left:auto;left:var(--swiper-scrollbar-left,auto);position:absolute;right:4px;right:var(--swiper-scrollbar-right,4px);top:1%;top:var(--swiper-scrollbar-sides-offset,1%);width:4px;width:var(--swiper-scrollbar-size,4px);z-index:50}.swiper-scrollbar-drag{background:rgba(0,0,0,.5);background:var(--swiper-scrollbar-drag-bg-color,rgba(0,0,0,.5));border-radius:10px;border-radius:var(--swiper-scrollbar-border-radius,10px);height:100%;left:0;position:relative;top:0;width:100%}.swiper-scrollbar-cursor-drag{cursor:move}.swiper-scrollbar-lock{display:none}</style> <style>.swiper-virtual .swiper-slide{-webkit-backface-visibility:hidden;transform:translateZ(0)}.swiper-virtual.swiper-css-mode .swiper-wrapper:after{content:"";left:0;pointer-events:none;position:absolute;top:0}.swiper-virtual.swiper-css-mode.swiper-horizontal .swiper-wrapper:after{height:1px;width:var(--swiper-virtual-size)}.swiper-virtual.swiper-css-mode.swiper-vertical .swiper-wrapper:after{height:var(--swiper-virtual-size);width:1px}</style> <style>.swiper-zoom-container{align-items:center;display:flex;height:100%;justify-content:center;text-align:center;width:100%}.swiper-zoom-container>canvas,.swiper-zoom-container>img,.swiper-zoom-container>svg{max-height:100%;max-width:100%;-o-object-fit:contain;object-fit:contain}.swiper-slide-zoomed{cursor:move;touch-action:none}</style> <style>.router-link-exact-active[data-v-ae15e636]{border-bottom-width:2px;--tw-border-opacity:1;border-color:rgba(var(--color-border-brand),var(--tw-border-opacity));--tw-text-opacity:1;color:rgba(var(--color-text-default),1);color:rgba(var(--color-text-default),var(--tw-text-opacity))}</style> <style>.download-btn[data-v-ffd1b8fd]{gap:var(--spacing-lg);width:100%}@media (min-width:1024px){.download-btn[data-v-ffd1b8fd]{width:-moz-fit-content;width:fit-content}}</style> <style>[data-v-4f3fc9a4] h2{font-size:revert;font-weight:600}[data-v-4f3fc9a4] h1{font-size:revert;font-weight:600}[data-v-4f3fc9a4] .publication-text ol{list-style-type:decimal;padding-left:var(--spacing-lg)}[data-v-4f3fc9a4] .publication-text ul{list-style-type:disc;padding-left:var(--spacing-lg)}</style> <style>[data-v-0016287f] .m-accordion__item span{font-size:.875rem;font-weight:600;line-height:1.25rem}</style> <style>.clamp-1{-webkit-line-clamp:1}.clamp-1,.clamp-2{display:-webkit-box;overflow:hidden;-webkit-box-orient:vertical}.clamp-2{-webkit-line-clamp:2}.clamp-3{-webkit-line-clamp:3}.clamp-3,.clamp-4{display:-webkit-box;overflow:hidden;-webkit-box-orient:vertical}.clamp-4{-webkit-line-clamp:4}.clamp-5{display:-webkit-box;overflow:hidden;-webkit-box-orient:vertical;-webkit-line-clamp:5}</style> <style>.m-tooltip[data-v-d8c082ee] .text-color-white{font-size:.75rem;font-weight:400;line-height:1rem;width:10rem;--tw-text-opacity:1;color:rgba(var(--color-text-subtle),1);color:rgba(var(--color-text-subtle),var(--tw-text-opacity))}</style> <style>.m-input[data-v-03f1a75d]{height:2.5rem;width:100%;--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity));font-size:.875rem;line-height:1.25rem;padding-left:var(--spacing-md);padding-right:var(--spacing-md)}</style> <style>.m-tag[data-v-3ce94018]{border-radius:.25rem;height:1.5rem;margin-right:var(--spacing-xs);--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity));font-size:.75rem;padding-left:var(--spacing-sm);--tw-text-opacity:1;color:rgba(var(--color-black),1);color:rgba(var(--color-black),var(--tw-text-opacity))}</style> <style>[data-v-da90062a] h2{font-size:1.125rem;font-weight:600;line-height:1.75rem;margin-top:-3rem;padding-bottom:var(--spacing-sm);padding-top:var(--spacing-7xl)}[data-v-da90062a] h4{font-size:1rem;font-weight:600;line-height:1.5rem;padding-bottom:var(--spacing-sm)}[data-v-da90062a] .html-p{font-size:1rem;line-height:1.5rem;padding-bottom:var(--spacing-lg)}[data-v-da90062a] .html-fig_img img,[data-v-da90062a] .html-table_wrap_td img{cursor:pointer;height:auto;margin:0 auto;width:100%}@media (min-width:1024px){[data-v-da90062a] .html-fig_img img,[data-v-da90062a] .html-table_wrap_td img{max-width:28.5rem}}[data-v-da90062a] .html-fig-wrap{padding-bottom:var(--spacing-lg);padding-top:var(--spacing-sm)}[data-v-da90062a] .html-fig_description,[data-v-da90062a] .html-table_wrap_discription{text-align:center}[data-v-da90062a] .html-disp-formula-info{display:flex;padding-bottom:var(--spacing-md);padding-top:var(--spacing-sm);width:100%}[data-v-da90062a] .html-disp-formula-info .f{width:80%}[data-v-da90062a] .html-disp-formula-info .l{text-align:right;width:20%}[data-v-da90062a] menu,[data-v-da90062a] ol,[data-v-da90062a] ul{list-style-type:decimal;padding-left:var(--spacing-md)}[data-v-da90062a] .mfp-content{display:none}[data-v-da90062a] .html-figpopup{margin:0 auto;max-width:28.5rem;position:relative}[data-v-da90062a] .html-bibr{position:relative}[data-v-da90062a] .mfp-popover{border-radius:1rem;height:auto;overflow-wrap:break-word;position:absolute;top:-5.875rem;width:24rem;z-index:10;--tw-bg-opacity:1;background-color:rgba(var(--color-white),1);background-color:rgba(var(--color-white),var(--tw-bg-opacity));font-size:.875rem;font-weight:400;line-height:1.25rem;padding:var(--spacing-md);--tw-shadow:0 1px 3px 0 rgba(0,0,0,.1),0 1px 2px -1px rgba(0,0,0,.1);--tw-shadow-colored:0 1px 3px 0 var(--tw-shadow-color),0 1px 2px -1px var(--tw-shadow-color);box-shadow:0 0 #0000,0 0 #0000,0 1px 3px 0 rgba(0,0,0,.1),0 1px 2px -1px rgba(0,0,0,.1);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000),var(--tw-ring-shadow,0 0 #0000),var(--tw-shadow)}[data-v-da90062a] .html-p dt{clear:left;float:left;padding-right:var(--spacing-md);text-align:right}[data-v-da90062a] .html-bullet .html-p{padding-bottom:0}.m-tag[data-v-da90062a]{border-radius:.25rem;height:1.5rem;margin-right:var(--spacing-xs);--tw-bg-opacity:1;background-color:rgba(var(--color-surface-subtle),1);background-color:rgba(var(--color-surface-subtle),var(--tw-bg-opacity));font-size:.75rem;padding-left:var(--spacing-sm);--tw-text-opacity:1;color:rgba(var(--color-black),1);color:rgba(var(--color-black),var(--tw-text-opacity))}.container[data-v-da90062a]{margin-top:var(--spacing-lg)!important;--tw-bg-opacity:1!important;background-color:rgba(var(--color-white),1)!important;background-color:rgba(var(--color-white),var(--tw-bg-opacity))!important;padding-bottom:var(--spacing-sm)!important;padding-top:var(--spacing-sm)!important}.container[data-v-da90062a] svg{display:none!important}.container[data-v-da90062a] .m-button{height:1.8125rem}[data-v-da90062a] .html-fig_show{display:none}[data-v-da90062a] .html-table_show{display:none}.cite-container[data-v-da90062a]{--tw-bg-opacity:1!important;background-color:rgba(var(--color-white),1)!important;background-color:rgba(var(--color-white),var(--tw-bg-opacity))!important;padding-bottom:var(--spacing-sm)!important;padding-top:var(--spacing-sm)!important}.cite-container[data-v-da90062a] svg{display:none!important}[data-v-da90062a] .m-accordion__item span{font-size:.875rem;font-weight:600;line-height:1.25rem}[data-v-da90062a] .heading-with-anchor{word-break:break-all}[data-v-da90062a] #html-copyright{display:none}[data-v-da90062a] .cross-ref,[data-v-da90062a] .google-scholar,[data-v-da90062a] .html-fig,[data-v-da90062a] .html-table{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}[data-v-da90062a] .cross-ref:hover,[data-v-da90062a] .google-scholar:hover,[data-v-da90062a] .html-fig:hover,[data-v-da90062a] .html-table:hover{text-decoration-line:underline}[data-v-da90062a] a.html-bibr{--tw-text-opacity:1;color:rgba(var(--color-text-link-bold),1);color:rgba(var(--color-text-link-bold),var(--tw-text-opacity))}[data-v-da90062a] a.html-bibr:hover{text-decoration-line:underline}</style> <style>[data-v-694159ae] .m-accordion__item span{font-size:.875rem;font-weight:600;line-height:1.25rem}</style> <link rel="stylesheet" href="/_nuxt/swiper-vue.B8Qtp0_B.css"> <link rel="stylesheet" href="/_nuxt/page.ChZXZrEc.css"> <link rel="stylesheet" href="/_nuxt/CommonReadmore.Cfzbs3YM.css"> <link rel="stylesheet" href="/_nuxt/imagePreview.BhKeW-wZ.css"> <link rel="stylesheet" href="/_nuxt/ScrollLoading.CtBH3zbC.css"> <link rel="stylesheet" href="/_nuxt/AppTurnstileWidget.BrwyvPaT.css"> <link rel="stylesheet" href="/_nuxt/ScrollTop.B6N0Xde5.css"> <link rel="preload" as="style" href="https://pub.mdpi-res.com/assets/fonts/suisse/fonts.css"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/C27HaHQc.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/4rkk1glR.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/OU_lvVvo.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/MELp_9y7.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DJ_2xEbf.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DlAUqK2U.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BzbGl42-.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/bRFCaPyp.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/Bq-k6d50.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BaC8YmpO.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CsnXxeeo.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/Sr7NgQmL.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CJtxWM-4.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D15uM1gO.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D3XMzgcc.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/Bp32iicF.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BVnInYB2.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CT_MnTdM.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/C2t5_0WB.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BenGTscT.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/YuxR3Pu0.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/Dnb9tpsV.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/B3frQi_Q.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DvALqv7A.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/vv2Rmwly.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BACJKBe0.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D3_cLRFw.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D4jAlUYG.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/C88fzhO7.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D3jZIeS7.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CO7npeQl.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BtWxVOE2.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CPniVYxA.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BrnKO0a8.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CXj84r_J.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BjFvKq7p.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BfP5Yj9h.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BCHjbcVH.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DF1xWhrB.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CSftCEdt.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BUG3EtXz.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/VRsIP4ye.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DWlQ7dfc.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/h5QvUJzN.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D9M9y3zY.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DBJwQKo_.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/DJGN3rr3.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/Dg_sg7_-.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BTCqNyt1.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BlIUE5gg.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D64oYWtW.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BkYV1aS-.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/B79UeM0F.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CgwdhZu1.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/BHDep5Fd.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/B1WVniK0.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/UIFFOgeC.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/D2qdJ5wO.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/vRa2jP_-.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/CVOIiGAr.js"> <link rel="modulepreload" as="script" crossorigin href="/_nuxt/YbQyBXQk.js"> <script src="https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js" id="shenembed" defer></script> <script src="https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js" defer></script> <link rel="prefetch" as="image" type="image/png" href="/_nuxt/error.BAMwz5-m.png"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BICt5lEk.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/C_7JoYtI.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BQ8VW0UK.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Ccci8845.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CkuUyBkI.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Cuo3bhE5.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BDkYyAbu.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D0OoxKuM.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DcrixLdV.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BhBO-Kc3.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DnPbqzsC.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Dy33lEfh.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/w6QCel6Y.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DPpMCftk.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DDd-OE0i.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CSqnbcsA.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CaOeis0O.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/COF9GGY2.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/K08Ei7DG.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/EctWdbgJ.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BI-xnQ7w.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BTzD6Mkk.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/300XsdT0.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CJjj_ExW.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/C4Aq_-0L.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DgIKUgP-.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BHnT5fTp.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DG3nBRT1.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Cc08nYod.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/C1MSWdJj.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D3Q2qhlM.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DE7mHYmK.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BFguvHUo.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DCTbMpoV.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BYolaAY_.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Rw14-rL_.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CgOid6gM.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DpzONys6.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DPOWjGPB.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DfhgFNlI.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Di81R11W.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BU8JUNi1.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/humBfqf4.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BvXbeU5U.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/cO8boWAA.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/4wO3PQLb.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CDOCVby7.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DFPnb23O.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CBfN9KOs.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DjwPEAHj.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BlnoRm-J.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D3TjGg_5.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DbuP4Er7.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Btm5aAIe.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CNt80UN-.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CnYjD6y0.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Lhw1vk9W.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/C_UTzjh5.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Bg_lpcMp.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/IlH6o1Jh.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/AzIJCIsq.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/kXd3pXrK.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/DMuDThNb.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/Drgz-R_C.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/COsaROqB.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/jKG2QKjb.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D_AqDHVt.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BSsPjorf.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D6pyfHxW.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BtlE8llv.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/CsZfyd4s.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BG3hnnwA.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D3Pg72e7.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/I2gzi7nk.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/7FoSU0FK.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/_nBJwZwe.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/piZhExQU.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/BmanIOt3.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/D1165OEy.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/eMP0HJlR.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/n5xr6Ozy.js"> <link rel="prefetch" as="script" crossorigin href="/_nuxt/A7zJygdy.js"> <link rel="prefetch" as="image" type="image/png" href="/_nuxt/preprints.C_f_-Qxj.png"> <link rel="prefetch" as="image" type="image/png" href="/_nuxt/publicAccount.3LRUWsx7.png"> <meta name="robots" content="index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1"> <script>window.loadTurnstile = new Promise(resolve => { window.onloadTurnstileCallback = function () { resolve(); delete window.onloadTurnstileCallback; delete window.loadTurnstile; } })</script> <script type="module" src="/_nuxt/C27HaHQc.js" crossorigin></script></head><body class="antialiased duration-300 transition-colors text-gray-800 dark:text-gray-200 bg-white dark:bg-gray-900"><div id="__nuxt"><div class="nuxt-loading-indicator" style="position:fixed;top:0;right:0;left:0;pointer-events:none;width:auto;height:3px;opacity:0;background:rgb(var(--color-brand-default));background-size:Infinity% auto;transform:scaleX(0%);transform-origin:left;transition:transform 0.1s, height 0.4s, opacity 0.4s;z-index:999999;"></div><div class="page-warpper"><header class="sticky top-0 w-full bg-[#fff] border-b border-color-default" style="z-index:10;"><div class="mx-auto flex max-w-mobile-fluid items-center justify-between lg:max-w-desktop-fluid max-w-[96%] py-sm lg:py-0"><div class="flex items-center"><a href="/" class="font-bold text-lg text-primary-500 py-2 lg:mr-xl xl:mr-7xl"><div class="w-36 h-auto"><img src="/_nuxt/preprints.C_f_-Qxj.png" alt="Prerpints.org logo" class="w-36 h-auto"></div></a><nav class="hidden lg:flex" data-v-ae15e636><ul class="flex flex-row lg:space-x-xl xl:space-x-3xl text-sm" data-v-ae15e636><li class="flex h-full items-center" data-v-ae15e636><a href="/instructions-for-authors" class="py-lg" data-v-ae15e636>Instructions for Authors</a></li><li class="flex h-full items-center" data-v-ae15e636><a href="/about" class="py-lg" data-v-ae15e636>About</a></li><li class="flex h-full items-center" data-v-ae15e636><a href="/faq" class="py-lg" data-v-ae15e636>FAQ</a></li><li class="flex h-full items-center" data-v-ae15e636><a href="/blog" class="py-lg" data-v-ae15e636>Blog and News</a></li></ul></nav></div><div class="flex"><span></span></div></div></header><div class="w-full" style="min-height:var(--layout-page-content-min-height);"><div data-v-ffd1b8fd><div data-v-ffd1b8fd><div data-v-ffd1b8fd><div class="bg-surface-subtle" data-v-ffd1b8fd><div class="m-container mx-auto w-full pb-xl lg:pb-3xl" style="--container-ideal-width:92.5vw;" data-v-ffd1b8fd><nav aria-label="Breadcrumbs" class="m-breadcrumb py-sm my-md lg:my-0 lg:py-xl lg:pt-3xl lg:pb-2xl overflow-x-auto" data-v-ffd1b8fd><ol class="m-breadcrumb__items flex items-center space-x-1 whitespace-pre text-xs text-color-subtle"><li class="flex items-center gap-1"><a href="/" class="m-breadcrumb__item hover:text-color-link-bolder flex text-color-black lg:hidden" data-v-ffd1b8fd><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="home" class="lg:hidden" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a><a href="/" class="m-breadcrumb__item hover:text-color-link-bolder hidden lg:block" data-v-ffd1b8fd>Home</a><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="chevron_right" style="" width="16" height="16" viewBox="0 0 16 16"></svg></li><li class="flex items-center gap-1"><a href="/subject" class="m-breadcrumb__item hover:text-color-link-bolder" data-v-ffd1b8fd>Medicine and Pharmacology</a><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="chevron_right" style="" width="16" height="16" viewBox="0 0 16 16"></svg></li><li class="flex items-center gap-1"><a href="/subject/browse/Transplantation?name=Medicine+and+Pharmacology&id=130" class="m-breadcrumb__item hover:text-color-link-bolder" data-v-ffd1b8fd>Transplantation</a><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="chevron_right" style="" width="16" height="16" viewBox="0 0 16 16"></svg></li><li class="flex items-center gap-1"><a aria-current="page" href="/manuscript/202403.0881/v2" class="router-link-active router-link-exact-active m-breadcrumb__item text-color-link-bold hover:text-color-link-bolder" data-v-ffd1b8fd>DOI:10.20944/preprints202403.0881.v2 </a></li></ol></nav><div class="lg:flex justify-between pt-sm" data-v-ffd1b8fd><div data-v-ffd1b8fd><div class="flex items-center" data-v-ffd1b8fd><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 mr-sm px-md !bg-surface-disabled !text-xs !text-color-default" data-v-ffd1b8fd><span class="flex items-center whitespace-nowrap text-xs leading-normal">Preprint</span></div><div class="m-tag flex items-center gap-2 rounded py-0.5 h-6 bg-content-inverse-subtler text-color-inverse px-2 mr-sm px-md !bg-surface-disabled !text-xs !text-color-default" data-v-ffd1b8fd>Review</div></div><div class="flex items-center pt-sm" data-v-ffd1b8fd><h4 class="m-heading text-inherit m-h4 font-normal" data-v-ffd1b8fd>Transfusions of Blood Products Derived from Genetic Vaccine Recipients: Safety Concerns and Proposals for Specific Measures</h4></div></div><div class="w-full max-w-xs lg:ml-3xl flex-none" data-v-ffd1b8fd><div class="flex justify-between items-end border-b border-color-default" data-v-ffd1b8fd><p class="m-text text-sm py-sm" data-v-ffd1b8fd>Altmetrics</p><div class="altmetric-embed" data-badge-type="donut" data-badge-popover="left" data-link-target="_blank" data-doi="10.20944/preprints202403.0881.v2" data-v-ffd1b8fd></div></div><div class="flex justify-between py-sm border-b border-color-default" data-v-ffd1b8fd><p class="m-text text-sm" data-v-ffd1b8fd>Downloads</p><p class="m-text text-sm" data-v-ffd1b8fd>19080</p></div><div class="flex justify-between py-sm border-b border-color-default" data-v-ffd1b8fd><p class="m-text text-sm" data-v-ffd1b8fd>Views</p><p class="m-text text-sm" data-v-ffd1b8fd>87271</p></div><div class="flex justify-between py-sm border-b border-color-default" data-v-ffd1b8fd><p class="m-text text-sm" data-v-ffd1b8fd>Comments</p><p class="m-text text-sm" data-v-ffd1b8fd>0</p></div></div></div></div></div><div class="m-container mx-auto w-full py-section-mobile pb-7xl max-w-mobile-fluid lg:max-w-desktop-fluid" style="--container-ideal-width:92.5vw;" data-v-ffd1b8fd><div class="lg:hidden" data-v-ffd1b8fd><div class="w-full lg:ml-lg flex-none lg:hidden" data-v-ffd1b8fd><div class="pt-md"><div class="flex justify-end mb-md"><button class="m-button m-button--md m-button--tonal rounded mr-sm !bg-surface-subtle !text-color-default" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="format_quote" style="" width="16" height="16" viewBox="0 0 16 16"></svg><span class="hidden lg:block">Cite</span></span></button><button class="m-button m-button--md m-button--tonal rounded mr-sm !bg-surface-subtle !text-color-default" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="mode_comment" style="" width="16" height="16" viewBox="0 0 16 16"></svg> <span class="hidden lg:block">Comments</span></span></button><button class="m-button m-button--md m-button--tonal rounded !bg-surface-subtle !text-color-default" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="share" style="" width="16" height="16" viewBox="0 0 16 16"></svg><span class="hidden lg:block">Share</span></span></button></div><div data-v-4f3fc9a4></div><div></div></div><div class="w-ull"><button class="m-button m-button--lg m-button--primary m-button--full-width rounded" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="download" style="" width="24" height="24" viewBox="0 0 16 16"></svg>Download PDF</span></button></div><div><div class="pb-md border-b border-color-default pt-sm"><div class="w-full relative overflow-hidden"><div><div class="clamp-3"><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/909446" target="_blank" rel="noopener noreferrer">Jun Ueda</a></span><sup> *</sup><div class="m-icon-custom text-color-inherit pl-xs inline-block"><a href="https://orcid.org/0000-0002-9766-203X" rel="noopener noreferrer" target="_blank"><img src="/_ipx/_/img/articleorcid.webp" onerror="this.setAttribute('data-error', 1)" data-nuxt-img srcset="/_ipx/_/img/articleorcid.webp 1x, /_ipx/_/img/articleorcid.webp 2x" class="w-4"></a></div><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/NmJydjdvK2cxZUhIeDlBaElhb1Nqdkd5L1Z6SEtoNmxhczNjd0g0Q016cz0=" target="_blank" rel="noopener noreferrer">Hideyuki Motohashi</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/K2VwKzNxaGhmRnRPazJVTVdVQ05SYmpQU1JsVzk5UkhPNjJweWZicG9HZz0=" target="_blank" rel="noopener noreferrer">Yuriko Hirai</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/3457934" target="_blank" rel="noopener noreferrer">Kenji Yamamoto</a></span><div class="m-icon-custom text-color-inherit pl-xs inline-block"><a href="https://orcid.org/0000-0003-4482-5816" rel="noopener noreferrer" target="_blank"><img src="/_ipx/_/img/articleorcid.webp" onerror="this.setAttribute('data-error', 1)" data-nuxt-img srcset="/_ipx/_/img/articleorcid.webp 1x, /_ipx/_/img/articleorcid.webp 2x" class="w-4"></a></div><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1272428" target="_blank" rel="noopener noreferrer">Yasufumi Murakami</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/ZE9Pai9sV2tiN1l5YzB2NmpvZm5EeHdiTHRlQjY5TjN1TEc3OUdtWWljRT0=" target="_blank" rel="noopener noreferrer">Masanori Fukushima</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/3438232" target="_blank" rel="noopener noreferrer">Akinori Fujisawa</a></span><sup> *</sup><div class="m-icon-custom text-color-inherit pl-xs inline-block"><a href="https://orcid.org/0009-0009-0483-505X" rel="noopener noreferrer" target="_blank"><img src="/_ipx/_/img/articleorcid.webp" onerror="this.setAttribute('data-error', 1)" data-nuxt-img srcset="/_ipx/_/img/articleorcid.webp 1x, /_ipx/_/img/articleorcid.webp 2x" class="w-4"></a></div></span></span></div><div class="invisible absolute"><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/909446" target="_blank" rel="noopener noreferrer">Jun Ueda</a></span><sup> *</sup><div class="m-icon-custom text-color-inherit pl-xs inline-block"><a href="https://orcid.org/0000-0002-9766-203X" rel="noopener noreferrer" target="_blank"><img src="/_ipx/_/img/articleorcid.webp" onerror="this.setAttribute('data-error', 1)" data-nuxt-img srcset="/_ipx/_/img/articleorcid.webp 1x, /_ipx/_/img/articleorcid.webp 2x" class="w-4"></a></div><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/NmJydjdvK2cxZUhIeDlBaElhb1Nqdkd5L1Z6SEtoNmxhczNjd0g0Q016cz0=" target="_blank" rel="noopener noreferrer">Hideyuki Motohashi</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/K2VwKzNxaGhmRnRPazJVTVdVQ05SYmpQU1JsVzk5UkhPNjJweWZicG9HZz0=" target="_blank" rel="noopener noreferrer">Yuriko Hirai</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/3457934" target="_blank" rel="noopener noreferrer">Kenji Yamamoto</a></span><div class="m-icon-custom text-color-inherit pl-xs inline-block"><a href="https://orcid.org/0000-0003-4482-5816" rel="noopener noreferrer" target="_blank"><img src="/_ipx/_/img/articleorcid.webp" onerror="this.setAttribute('data-error', 1)" data-nuxt-img srcset="/_ipx/_/img/articleorcid.webp 1x, /_ipx/_/img/articleorcid.webp 2x" class="w-4"></a></div><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/1272428" target="_blank" rel="noopener noreferrer">Yasufumi Murakami</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><span><a href="https://sciprofiles.com/profile/author/ZE9Pai9sV2tiN1l5YzB2NmpvZm5EeHdiTHRlQjY5TjN1TEc3OUdtWWljRT0=" target="_blank" rel="noopener noreferrer">Masanori Fukushima</a></span><span>,</span></span></span><span class="pr-sm"><span class="m-text text-sm"><div class="m-avatar flex items-center justify-center overflow-hidden rounded-full bg-brand-bold font-medium text-color-on-brand h-5 w-5 min-w-5 text-[0.575rem] !inline-block align-middle mr-xs" data-testid="m-avatar"><img src="/statics/img/design/default-user.png"><span class="sr-only"></span></div><span><a href="https://sciprofiles.com/profile/3438232" target="_blank" rel="noopener noreferrer">Akinori Fujisawa</a></span><sup> *</sup><div class="m-icon-custom text-color-inherit pl-xs inline-block"><a href="https://orcid.org/0009-0009-0483-505X" rel="noopener noreferrer" target="_blank"><img src="/_ipx/_/img/articleorcid.webp" onerror="this.setAttribute('data-error', 1)" data-nuxt-img srcset="/_ipx/_/img/articleorcid.webp 1x, /_ipx/_/img/articleorcid.webp 2x" class="w-4"></a></div></span></span></div></div><div style="display:none;" class="mt-sm"><button class="m-button m-button--sm m-button--tertiary rounded !inline-flex after:hidden bg-white" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center">Show more <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" style="" width="16" height="16" viewBox="0 0 16 16"></svg></span></button></div></div><p class="m-text text-sm text-color-error pt-sm">This version is not peer-reviewed</p></div><div class="m-accordion mx-auto flex w-full flex-col gap-3 rounded-2xl bg-white"><div class="m-accordion__item border-b border-color-default"><button id="accordion-button-expand-0" aria-controls="accordion-panel-0" class="relative mb-xs flex w-full cursor-pointer py-md text-sm outline-offset-2" aria-expanded="true"><span class="text-sm">This preprints belongs to the Collection</span><div class="absolute right-0 top-1/2 -translate-y-1/2"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="origin-center transition duration-150 rotate-180" style="" width="16" height="16" viewBox="0 0 16 16"></svg></div></button><div id="accordion-panel-0" aria-labelledby="accordion-button-expand-0" role="region" class="m-accordion__body overflow-hidden transition-height duration-150"><div class="break-words pb-md"><div class="flex items-center"><p class="m-text text-sm text-color-link-bold cursor-pointer">Preprints on COVID-19 and SARS-CoV-2</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="arrow_right_alt" class="text-color-link-bold cursor-pointer" style="" width="16" height="16" viewBox="0 0 16 16"></svg></div></div></div></div></div></div><div class="py-md border-b border-color-default"><div class="m-select common-field bg-white"><div class="common-field__wrapper" data-headlessui-state><div class="relative w-full cursor-default"><div class="flex items-center"><button id="headlessui-listbox-button-mui-2290" type="button" aria-haspopup="listbox" aria-expanded="false" data-headlessui-state data-testid="select-activator" class="common-field__dropdown-input [&>span]:overflow-hidden h-10"><span class="flex w-full items-center gap-1 [&>span]:truncate"><span>Version 2</span></span><div class="flex"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="duration-400 transition-transform" style="" width="24" height="24" viewBox="0 0 16 16"></svg></div></button></div></div></div></div><div class="pt-sm"><div class="flex"><p class="m-text text-xs">Submitted:</p><p class="m-text text-xs pl-xs">28 May 2024</p></div><div class="flex pt-sm"><p class="m-text text-xs">Posted: </p><p class="m-text text-xs pl-xs">29 May 2024</p></div></div><div class="pt-sm"><div><p class="m-text text-xs">You are already at the latest version </p></div></div><div></div></div><div class="py-md border-b border-color-default flex items-center justify-between" data-v-d8c082ee><div class="flex-none flex items-center" data-v-d8c082ee><span class="m-text text-xs pr-xs font-semibold flex-none" data-v-d8c082ee>Alerts</span><span data-v-d8c082ee></span></div><div class="m-switch flex items-center gap-2" data-v-d8c082ee><button class="relative inline-flex h-[1.4rem] w-[2.75rem] shrink-0 cursor-pointer items-center rounded-full border-2 border-color-transparent transition-colors duration-150 ease-out ui-focus-visible:ring-2 ui-focus-visible:ring-brand-bold ui-focus-visible:ring-opacity-75 bg-content-default hover:bg-content-bold active:bg-content-bolder" aria-label="Switch on" id="headlessui-switch-mui-2291" role="switch" type="button" tabindex="0" aria-checked="false" data-headlessui-state><span aria-hidden="true" class="pointer-events-none inline-block h-[1rem] w-[1rem] transform rounded-full bg-white shadow-lg ring-0 transition duration-200 ease-in-out translate-x-0.5"></span></button></div></div><div data-v-d8c082ee data-v-03f1a75d></div><div><h6 class="m-heading text-inherit m-h6 font-semibold pt-lg">Abstract</h6><div class=""><p>The World Health Organization declared the coronavirus disease 2019 (COVID-19) pandemic in 2020, following which a global genetic vaccination program has been rapidly implemented as a fundamental solution. However, it has been reported worldwide that the modified mRNAs encoding spike proteins and lipid nanoparticles, which are used as drug delivery systems, not only cause thrombosis and cardiovascular disorders post vaccination, but might also cause diverse diseases involving all organs and systems, including the nervous system. Furthermore, the toxicity and pathogenicity of spike proteins may necessitate defining these proteins as nonbiological infective material. Based on these reports and the abundant evidence that has come to light in the past few years, this paper aims to draw the attention of medical professionals to the various risks associated with transfusion using blood products derived from long COVID patients or from genetic vaccine recipients, and to make proposals regarding specific inspection items, testing methods, regulations, etc. This paper provides insights to address the post-vaccination syndrome and its consequences following such genetic vaccination programs.</p></div></div><div data-v-3ce94018><div class="pt-lg" data-v-3ce94018><span class="m-text text-body font-semibold" data-v-3ce94018>Keywords: </span><span class="m-text text-body pt-sm" data-v-3ce94018></span></div></div><div class="flex-1 pt-lg mr-lg lg:pt-0" data-v-da90062a><div class="pt-md" data-v-da90062a><div class="flex flex-wrap lg:flex-nowrap items-center" data-v-da90062a><span class="m-text text-body font-semibold" data-v-da90062a>Subject: </span><span class="m-text text-body" data-v-da90062a>Medicine and Pharmacology</span><span class="" data-v-da90062a> - </span><span class="m-text text-body" data-v-da90062a>Transplantation</span></div></div><div class="content-container" id="articleRef" data-v-da90062a><script type="text/x-mathjax-config"> MathJax.Hub.Config({ menuSettings: { CHTMLpreview: false }, "CHTML-preview":{ disabled: true }, "HTML-CSS": { scale: 90, availableFonts: [], preferredFont: null, preferredFonts: null, webFont:"Gyre-Pagella", imageFont:'TeX', undefinedFamily:"'Arial Unicode MS',serif", linebreaks: { automatic: false } }, "TeX": { extensions: ["noErrors.js"], noErrors: { inlineDelimiters: ["",""], multiLine: true, style: { "font-size": "90%", "text-align": "left", "color": "black", "padding": "1px 3px", "border": "1px solid" } } } }); </script><script type="text/javascript" async="" src="https://www.mdpi.com/bundles/mathjax/MathJax.js?config=TeX-AMS-MML_HTMLorMML"></script> <section id="sec1-preprints-107672" type="intro"><h2 data-nested="1" id="preprints-h2-1"> 1. Introduction</h2> <div class="html-p">On March 11, 2020, the Director-General of the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) pandemic, caused by severe-acute-respiratory-syndrome-related coronavirus (SARS-CoV-2) [<a href="#B1-preprints-107672" class="html-bibr">1</a>], and countries worldwide actively implemented classical public health measures, including quarantine, isolation, disinfection, and lockdowns. However, hopes for a vaccine grew as the general consensus was that rapid herd immunity was the best solution to overcome the pandemic. Therefore, since 2021, as a means to combat SARS-CoV-2 infection, several global pharmaceutical companies have developed various genetic vaccines that use the spike protein of the Wuhan strain of SARS-CoV-2 as an antigen, following which rapid vaccination has been promoted on a global scale [<a href="#B2-preprints-107672" class="html-bibr">2</a>,<a href="#B3-preprints-107672" class="html-bibr">3</a>]. During this period (2020-2022), virological studies on SARS-CoV-2 have been intensively conducted, and the pathogenic mechanism of this virus has been elucidated in detail [<a href="#B4-preprints-107672" class="html-bibr">4</a>,<a href="#B5-preprints-107672" class="html-bibr">5</a>]. In brief, the key pathogenic processes include binding of the spike protein of SARS-CoV-2 to the angiotensin-converting enzyme 2 receptor on vascular endothelial cells, allowing viral entry and amplification [<a href="#B6-preprints-107672" class="html-bibr">6</a>]; triggering of red blood cell and platelet aggregation by the spike protein [<a href="#B7-preprints-107672" class="html-bibr">7</a>,<a href="#B8-preprints-107672" class="html-bibr">8</a>,<a href="#B9-preprints-107672" class="html-bibr">9</a>,<a href="#B10-preprints-107672" class="html-bibr">10</a>,<a href="#B11-preprints-107672" class="html-bibr">11</a>]; and formation of microthrombi [<a href="#B12-preprints-107672" class="html-bibr">12</a>,<a href="#B13-preprints-107672" class="html-bibr">13</a>].</div> <div class="html-p"> Genetic vaccines, such as mRNA vaccines that encode spike proteins, have caused a wide variety of diseases in all organs and systems of the human body, including the nervous system, in addition to thrombosis, which has resulted in cardiovascular disorders in vaccine recipients [<a href="#B14-preprints-107672" class="html-bibr">14</a>,<a href="#B15-preprints-107672" class="html-bibr">15</a>,<a href="#B16-preprints-107672" class="html-bibr">16</a>,<a href="#B17-preprints-107672" class="html-bibr">17</a>,<a href="#B18-preprints-107672" class="html-bibr">18</a>,<a href="#B19-preprints-107672" class="html-bibr">19</a>,<a href="#B20-preprints-107672" class="html-bibr">20</a>,<a href="#B21-preprints-107672" class="html-bibr">21</a>]. Thrombosis is induced in the vaccine recipient by the spike proteins produced from the mRNA or DNA introduced via the genetic vaccine when the foreign gene is introduced into autologous cells using gene-transfer capable lipid nanoparticles (LNPs) or other means. Although evidence for specific problems has been reported individually, Parry et al. have proposed the theory of spikeopathy (spike disease) as a hypothesis that synthesizes all of the evidence for this problem [<a href="#B22-preprints-107672" class="html-bibr">22</a>]. Furthermore, two general mechanisms are proposed by which a modified gene introduced into the body by genetic vaccination as well as some of the antigens produced by its expression can be transmitted throughout the body. First, LNPs encapsulating modified mRNA can spread throughout the body via the bloodstream from the injection site and can accumulate in specific organs, such as the liver, spleen, ovaries, testes, and bone marrow [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B23-preprints-107672" class="html-bibr">23</a>]. Second, pseudouridinated mRNA molecules and synthesized spike proteins can be released as extracellular vesicles, or exosomes, from cells that have incorporated the LNPs. These exosomes are transported in the circulation throughout the body to reach various organs [<a href="#B24-preprints-107672" class="html-bibr">24</a>,<a href="#B25-preprints-107672" class="html-bibr">25</a>,<a href="#B26-preprints-107672" class="html-bibr">26</a>,<a href="#B27-preprints-107672" class="html-bibr">27</a>]. Furthermore, spike proteins produced by cells that have taken up the modified gene travel throughout the body in the bloodstream (<a href="#preprints-107672-f001" class="html-fig">Figure 1</a>) [<a href="#B28-preprints-107672" class="html-bibr">28</a>,<a href="#B29-preprints-107672" class="html-bibr">29</a>]. Thus, the risk of inducing various health conditions can be attributed to the transport, distribution, and expression of the components of the genetic vaccine beyond the administration site to organs and tissues of the whole body.</div> <div class="html-p">Although the Director-General of the WHO declared the end of the COVID-19 public health emergency on May 5, 2023, post-vaccination syndrome (PVS) caused by genetic vaccines has become a major global problem [<a href="#B19-preprints-107672" class="html-bibr">19</a>,<a href="#B21-preprints-107672" class="html-bibr">21</a>,<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B30-preprints-107672" class="html-bibr">30</a>], requiring a reasonable harm–benefit assessment of the global use of such vaccines [<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B31-preprints-107672" class="html-bibr">31</a>,<a href="#B32-preprints-107672" class="html-bibr">32</a>,<a href="#B33-preprints-107672" class="html-bibr">33</a>]. Since the beginning of the coronavirus pandemic and following vaccination with genetic vaccines, the safety of blood products and their use in transfusions has been debated [<a href="#B34-preprints-107672" class="html-bibr">34</a>,<a href="#B35-preprints-107672" class="html-bibr">35</a>,<a href="#B36-preprints-107672" class="html-bibr">36</a>,<a href="#B37-preprints-107672" class="html-bibr">37</a>,<a href="#B38-preprints-107672" class="html-bibr">38</a>,<a href="#B39-preprints-107672" class="html-bibr">39</a>]. However, owing to a lack of understanding of the pathology of SARS-CoV-2 at the beginning of the pandemic, specific discussions, based on the data or on the analysis of the problem and its risks, were not attempted; only concerns were expressed, and no clear conclusions or policies were drawn. For example, Jacobs et al. stated that hospitals were not required to collect the genetic vaccination status of blood donors or to inform patients about the same [<a href="#B37-preprints-107672" class="html-bibr">37</a>] because, until 2021, health issues arising from vaccination with genetic vaccines had not been reported. Contrary to initial expectations, genes and proteins from genetic vaccines were found to persist in the blood of vaccine recipients for prolonged periods of time [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B28-preprints-107672" class="html-bibr">28</a>,<a href="#B40-preprints-107672" class="html-bibr">40</a>,<a href="#B41-preprints-107672" class="html-bibr">41</a>,<a href="#B42-preprints-107672" class="html-bibr">42</a>,<a href="#B43-preprints-107672" class="html-bibr">43</a>,<a href="#B44-preprints-107672" class="html-bibr">44</a>,<a href="#B45-preprints-107672" class="html-bibr">45</a>], causing a variety of adverse events. Roubinian et al. reported that transfusions of plasma and platelet blood components collected before and after COVID-19 vaccination were not associated with increased adverse outcomes in transfusion recipients who did not develop COVID-19 [<a href="#B39-preprints-107672" class="html-bibr">39</a>]. However, they only evaluated plasma and platelet preparations, not red blood cell or whole blood preparations. Moreover, the study only followed up recipients to the point of 30-day readmission rates; therefore, the long-term effects remain unclear.</div> <div class="html-p">Genetic vaccines are the equivalent of biomedicine (i.e. immune therapeutics) rather than conventional vaccines in terms of their mechanism of action [<a href="#B46-preprints-107672" class="html-bibr">46</a>,<a href="#B47-preprints-107672" class="html-bibr">47</a>]. The various genetic vaccines currently treated as vaccines should originally have been treated as biomedicine; however, because they were classified as vaccines, huge numbers of people were inoculated with them [<a href="#B2-preprints-107672" class="html-bibr">2</a>,<a href="#B3-preprints-107672" class="html-bibr">3</a>]. As a result, extensive areas of medicine are now beginning to be affected because most of the population in many countries has been vaccinated [<a href="#B19-preprints-107672" class="html-bibr">19</a>,<a href="#B21-preprints-107672" class="html-bibr">21</a>,<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B30-preprints-107672" class="html-bibr">30</a>,<a href="#B48-preprints-107672" class="html-bibr">48</a>], which possibly indicates that blood products for transfusion have been affected by these genetic vaccines. Considering the volume of evidence that has recently come to light, this paper aims to raise awareness among relevant parties and suggest specific recommendations regarding the use of blood products derived from genetic vaccine recipients, including those who have received mRNA vaccines. Furthermore, this paper examines the current risks of blood transfusions when genetic vaccines are administered in large quantities. The vaccine recipients described in this paper are limited to genetic vaccine recipients.</div></section><section id="sec2-preprints-107672" type><h2 data-nested="1" id="preprints-h2-2"> 2. Overview of Cases of Blood Abnormalities after Vaccination with Genetic Vaccines</h2> <div class="html-p">A wide variety of diseases related to blood and blood vessels, such as thrombosis, have developed after vaccination with genetic vaccines, including many cases of serious health injuries. For example, a PubMed search on diseases such as thrombocytopenia, thrombotic disorders with thrombocytopenia, deep vein thrombosis, thrombocytopenic purpura, cutaneous vasculitis, and sinus thrombosis combined with the essential keywords "COVID-19 vaccine" and "side effects" yielded several hundred articles in the two years since the rollout of genetic vaccines [<a href="#B14-preprints-107672" class="html-bibr">14</a>,<a href="#B17-preprints-107672" class="html-bibr">17</a>,<a href="#B20-preprints-107672" class="html-bibr">20</a>,<a href="#B21-preprints-107672" class="html-bibr">21</a>,<a href="#B49-preprints-107672" class="html-bibr">49</a>]. Microscopic observation has revealed that in addition to abnormally shaped red blood cells, amorphous material has been found floating in the blood of mRNA-vaccinated individuals, some of which has shown grossly abnormal findings (<a href="#preprints-107672-t001" class="html-table">Table 1</a>, point 2 and 5) [<a href="#B7-preprints-107672" class="html-bibr">7</a>,<a href="#B8-preprints-107672" class="html-bibr">8</a>,<a href="#B9-preprints-107672" class="html-bibr">9</a>,<a href="#B10-preprints-107672" class="html-bibr">10</a>,<a href="#B11-preprints-107672" class="html-bibr">11</a>,<a href="#B50-preprints-107672" class="html-bibr">50</a>]. The spike protein has amyloidogenic potential [<a href="#B51-preprints-107672" class="html-bibr">51</a>,<a href="#B52-preprints-107672" class="html-bibr">52</a>,<a href="#B53-preprints-107672" class="html-bibr">53</a>,<a href="#B54-preprints-107672" class="html-bibr">54</a>,<a href="#B55-preprints-107672" class="html-bibr">55</a>], is neurotoxic [<a href="#B56-preprints-107672" class="html-bibr">56</a>,<a href="#B57-preprints-107672" class="html-bibr">57</a>,<a href="#B58-preprints-107672" class="html-bibr">58</a>], and can cross the blood–brain barrier [<a href="#B59-preprints-107672" class="html-bibr">59</a>,<a href="#B60-preprints-107672" class="html-bibr">60</a>,<a href="#B61-preprints-107672" class="html-bibr">61</a>], which suggests that the spike protein used as an antigen in genetic vaccines might itself be toxic [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B62-preprints-107672" class="html-bibr">62</a>,<a href="#B63-preprints-107672" class="html-bibr">63</a>].</div> <div class="html-p">Individuals who have received multiple doses of a genetic vaccine may have multiple exposures to the same antigen within a brief period, thereby being imprinted with a preferential immune response to that antigen [<a href="#B64-preprints-107672" class="html-bibr">64</a>,<a href="#B65-preprints-107672" class="html-bibr">65</a>,<a href="#B66-preprints-107672" class="html-bibr">66</a>,<a href="#B67-preprints-107672" class="html-bibr">67</a>]. This phenomenon, called original antigenic sin or immune imprinting, may have caused COVID-19 vaccine recipients to become more susceptible to contracting COVID-19 [<a href="#B68-preprints-107672" class="html-bibr">68</a>]. Moreover, such vaccine recipients are also at a risk of antibody-dependent enhancement of infection, whereby antibodies produced by vaccination promote viral infection and symptoms [<a href="#B69-preprints-107672" class="html-bibr">69</a>,<a href="#B70-preprints-107672" class="html-bibr">70</a>]. In contrast, repeated administration of genetic vaccines may result in immune tolerance because of a class switch to non-inflammatory immunoglobulin G4 (IgG4) [<a href="#B71-preprints-107672" class="html-bibr">71</a>,<a href="#B72-preprints-107672" class="html-bibr">72</a>,<a href="#B73-preprints-107672" class="html-bibr">73</a>,<a href="#B74-preprints-107672" class="html-bibr">74</a>,<a href="#B75-preprints-107672" class="html-bibr">75</a>,<a href="#B76-preprints-107672" class="html-bibr">76</a>], whereby the immune system of the recipient does not mount an excessive response such as cytokine storm [<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B77-preprints-107672" class="html-bibr">77</a>], as evidenced by case reports of IgG4-related disease [<a href="#B78-preprints-107672" class="html-bibr">78</a>,<a href="#B79-preprints-107672" class="html-bibr">79</a>,<a href="#B80-preprints-107672" class="html-bibr">80</a>]. Such alterations in immune function due to immune imprinting and immunoglobulin class switching to IgG4 occurring in genetic vaccine recipients is a cause for concern as these may increase the risk of serious illness due to opportunistic infections or pathogenic viruses that would not pose a problem in a normal immune system [<a href="#B81-preprints-107672" class="html-bibr">81</a>,<a href="#B82-preprints-107672" class="html-bibr">82</a>,<a href="#B83-preprints-107672" class="html-bibr">83</a>,<a href="#B84-preprints-107672" class="html-bibr">84</a>,<a href="#B85-preprints-107672" class="html-bibr">85</a>,<a href="#B86-preprints-107672" class="html-bibr">86</a>,<a href="#B87-preprints-107672" class="html-bibr">87</a>]. Therefore, from the perspective of traditional containment of infectious diseases, greater caution is required in the collection of blood from genetic vaccine recipients and in the subsequent handling of blood products, as well as during solid organ transplantation and even during surgical procedures [<a href="#B88-preprints-107672" class="html-bibr">88</a>,<a href="#B89-preprints-107672" class="html-bibr">89</a>,<a href="#B90-preprints-107672" class="html-bibr">90</a>,<a href="#B91-preprints-107672" class="html-bibr">91</a>,<a href="#B92-preprints-107672" class="html-bibr">92</a>] to avoid the risk of accidental blood-borne infections (<a href="#preprints-107672-t001" class="html-table">Table 1</a>, point 3) [<a href="#B89-preprints-107672" class="html-bibr">89</a>,<a href="#B90-preprints-107672" class="html-bibr">90</a>,<a href="#B91-preprints-107672" class="html-bibr">91</a>,<a href="#B92-preprints-107672" class="html-bibr">92</a>]. Although the phenomenon of immune imprinting can occur even when spike protein is not used as an antigen or when another antigen is used (e.g., inactivated influenza vaccine) [<a href="#B93-preprints-107672" class="html-bibr">93</a>], in case of genetic vaccines, which produce an antigen within the body, the period of exposure to the same antigen might be prolonged, resulting in the risk of immune imprinting being higher than with conventional inactivated vaccines. The duration for which vaccine components remain in the body after a person has received a genetic vaccine is yet unknown [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B40-preprints-107672" class="html-bibr">40</a>,<a href="#B43-preprints-107672" class="html-bibr">43</a>]; however, it is expected that they remain in the body for a longer period than that originally thought, partly based on reports of spike protein being detected in vaccinated individuals several months post vaccination (<a href="#preprints-107672-t001" class="html-table">Table 1</a>, point 1) [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B28-preprints-107672" class="html-bibr">28</a>,<a href="#B41-preprints-107672" class="html-bibr">41</a>,<a href="#B42-preprints-107672" class="html-bibr">42</a>]. In addition, the immune dysfunction of genetic vaccine recipients is expected to be prolonged owing to immunoglobulin class switching to IgG4 [<a href="#B71-preprints-107672" class="html-bibr">71</a>,<a href="#B73-preprints-107672" class="html-bibr">73</a>,<a href="#B76-preprints-107672" class="html-bibr">76</a>] due to long-term exposure to a specific identical antigen (in this case, spike protein), and also because some of the B cells that produce IgG4 are likely to differentiate into memory B cells that survive in the body for a sustained period [<a href="#B73-preprints-107672" class="html-bibr">73</a>,<a href="#B94-preprints-107672" class="html-bibr">94</a>] (<a href="#preprints-107672-t001" class="html-table">Table 1</a>, point 3 & 6). In contrast, modified (N1-methyl-pseudouridylated) mRNAs cause a decrease in immune function if they remain in the body for an extended period of time [<a href="#B76-preprints-107672" class="html-bibr">76</a>]. </div> <div class="html-p">In summary, receiving blood products derived from blood collected in, at least, a brief deferral period after vaccination with genetic vaccines might pose a health risk for some patients. Although occurrence of secondary damage caused by transfusion of blood products derived from genetic vaccine recipients is yet unknown, it is vital that medical institutions and administrative organizations respond and investigate cooperatively keeping various possibilities in mind, especially considering that mechanisms such as the toxicity of the spike protein itself and the effects of LNPs and modified mRNA on the immune response have not been fully elucidated. A significant proportion of the COVID-19 PVS in mRNA vaccine recipients is due to toxic spike proteins, and the inclusion of structures in the receptor-binding domain within these proteins might induce prion disease, as Seneff et al. and Perez et al. have reported [<a href="#B51-preprints-107672" class="html-bibr">51</a>,<a href="#B95-preprints-107672" class="html-bibr">95</a>,<a href="#B96-preprints-107672" class="html-bibr">96</a>,<a href="#B97-preprints-107672" class="html-bibr">97</a>,<a href="#B98-preprints-107672" class="html-bibr">98</a>,<a href="#B99-preprints-107672" class="html-bibr">99</a>,<a href="#B100-preprints-107672" class="html-bibr">100</a>,<a href="#B101-preprints-107672" class="html-bibr">101</a>]. Furthermore, prion similarity in the receptor-binding domain exists not only in the spike protein of the Wuhan strain, which is still used as an antigen in genetic vaccines, but also in that of variants of SARS-CoV-2, such as the Delta strain, with the exception of the Omicron strain [<a href="#B98-preprints-107672" class="html-bibr">98</a>,<a href="#B102-preprints-107672" class="html-bibr">102</a>]. Further studies are required to ascertain whether uniform vigilance is required for the spike protein of all coronavirus strains or just the spike protein of certain variants, such as the Wuhan strain.</div></section><section id="sec3-preprints-107672" type><h2 data-nested="1" id="preprints-h2-3"> 3. Specific Proposals for Blood Sampling and Use of Blood Products from Vaccine Recipients</h2> <div class="html-p">In the previous section, blood-related abnormalities that have occurred following vaccination with genetic vaccines were discussed. In this section, specific proposals on how to respond to these health conditions are provided. Blood contamination affects several areas of health care; therefore, it is crucial to plan beforehand and be vigilant to avoid these occurrences [<a href="#B100-preprints-107672" class="html-bibr">100</a>,<a href="#B101-preprints-107672" class="html-bibr">101</a>,<a href="#B103-preprints-107672" class="html-bibr">103</a>,<a href="#B104-preprints-107672" class="html-bibr">104</a>,<a href="#B105-preprints-107672" class="html-bibr">105</a>].</div> <section id="sec3dot1-preprints-107672" type><h4 class="html-italic" data-nested="2"> 3.1. Additional Requirements for Blood Collection (Donation)</h4> <div class="html-p">Currently, in Japan, the Japanese Red Cross Society (<a href="https://www.jrc.or.jp/english/" target="_blank">https://www.jrc.or.jp/english/</a>) plays a central role in blood collection activities, and its blood products are used for blood transfusions and other purposes. The current rules of the Japanese Red Cross Society state that blood can be collected from genetic vaccine recipients after a deferral period (48 hours for mRNA vaccine recipients and 6 weeks for AstraZeneca DNA vaccine recipients); however, the data and rationale for such rules have not been specified. Similar to procedures for infections such as human immunodeficiency virus and prion diseases, a history of genetic vaccination (DNA and/or mRNA type), including timing and number of doses, should be obtained by interview when blood is collected, and maintained in the official record (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>, <a href="#preprints-107672-t002" class="html-table">Table 2</a>). Additional caution is warranted, particularly in cases where sufficient number of days have elapsed since the genetic vaccine was administered, because LNPs [<a href="#B23-preprints-107672" class="html-bibr">23</a>,<a href="#B106-preprints-107672" class="html-bibr">106</a>,<a href="#B107-preprints-107672" class="html-bibr">107</a>,<a href="#B108-preprints-107672" class="html-bibr">108</a>,<a href="#B109-preprints-107672" class="html-bibr">109</a>] and spike protein mRNA, which can induce inflammation, may continue to remain in the blood (<a href="#preprints-107672-t001" class="html-table">Table 1</a>, point 4) [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B40-preprints-107672" class="html-bibr">40</a>,<a href="#B43-preprints-107672" class="html-bibr">43</a>,<a href="#B44-preprints-107672" class="html-bibr">44</a>]. In cases where certain events such as anaphylactic shock occurred immediately after genetic vaccination, the effects of LNPs should also be suspected [<a href="#B110-preprints-107672" class="html-bibr">110</a>]. Negatively charged LNPs themselves interact with fibrinogen to form thrombi [<a href="#B111-preprints-107672" class="html-bibr">111</a>], and because LNP induces inflammation, it may cause thromboinflammation by itself [<a href="#B112-preprints-107672" class="html-bibr">112</a>]. Therefore, the presence of LNPs may in itself be a factor that should be viewed with caution when using transfusion products.</div> <div class="html-p">In contrast, in cases where individuals underwent long COVID without receiving a genetic vaccine, the likelihood of the spike protein remaining in their body is possible; therefore, maintaining official records of the occurrence of long COVID is essential [<a href="#B52-preprints-107672" class="html-bibr">52</a>,<a href="#B113-preprints-107672" class="html-bibr">113</a>,<a href="#B114-preprints-107672" class="html-bibr">114</a>,<a href="#B115-preprints-107672" class="html-bibr">115</a>]. The degradation rates of pseudouridinated mRNA and spike protein in the body are yet unknown; therefore, blood products derived from genetic vaccine recipients should be used with extreme caution, considering that cases of AIDS, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD), caused by the use of contaminated blood products, have occurred earlier [<a href="#B105-preprints-107672" class="html-bibr">105</a>,<a href="#B116-preprints-107672" class="html-bibr">116</a>,<a href="#B117-preprints-107672" class="html-bibr">117</a>,<a href="#B118-preprints-107672" class="html-bibr">118</a>,<a href="#B119-preprints-107672" class="html-bibr">119</a>,<a href="#B120-preprints-107672" class="html-bibr">120</a>,<a href="#B121-preprints-107672" class="html-bibr">121</a>,<a href="#B122-preprints-107672" class="html-bibr">122</a>,<a href="#B123-preprints-107672" class="html-bibr">123</a>].</div></section><section id="sec3dot2-preprints-107672" type><h4 class="html-italic" data-nested="2"> 3.2. Handling of Existing Blood Products</h4> <div class="html-p">Currently, the genetic vaccination status of blood donors is not confirmed or controlled by organizations, including medical institutions, and the use of blood collected from such donors for transfusions may pose risks to patients. Therefore, when blood products derived from genetic vaccine recipients are used, it is necessary to confirm the presence or absence of spike protein or modified mRNA as performed in tests for pathogens (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>, <a href="#preprints-107672-t002" class="html-table">Table 2</a>). Presence of spike protein or modified mRNA should be quantified by an immunochemical enzyme-linked immunosorbent assay, immunophenotyping, direct mass spectrometry of the protein itself, exosome-based liquid biopsy as used in cancer screening, or PCR [<a href="#B28-preprints-107672" class="html-bibr">28</a>,<a href="#B29-preprints-107672" class="html-bibr">29</a>,<a href="#B124-preprints-107672" class="html-bibr">124</a>,<a href="#B125-preprints-107672" class="html-bibr">125</a>,<a href="#B126-preprints-107672" class="html-bibr">126</a>,<a href="#B127-preprints-107672" class="html-bibr">127</a>,<a href="#B128-preprints-107672" class="html-bibr">128</a>,<a href="#B129-preprints-107672" class="html-bibr">129</a>,<a href="#B130-preprints-107672" class="html-bibr">130</a>]. For protein assays, mass spectrometry could be used as an initial step to identify and quantify the spike protein itself in blood [<a href="#B28-preprints-107672" class="html-bibr">28</a>,<a href="#B126-preprints-107672" class="html-bibr">126</a>] as it may take time to generate a good-quality anti-spike protein antibody or a positive control for a recombinant spike protein to be compared with, and to sort and distribute them to each laboratory. Concurrently, the components of the spike protein-induced amyloid material should be analyzed [<a href="#B52-preprints-107672" class="html-bibr">52</a>,<a href="#B131-preprints-107672" class="html-bibr">131</a>], and once identified, these could be used as biomarkers in future studies. Furthermore, exosome analysis could also be used for these investigations because spike proteins and the genes encoding them are circulated throughout the body by exosomes (<a href="#preprints-107672-f001" class="html-fig">Figure 1</a>) [<a href="#B24-preprints-107672" class="html-bibr">24</a>,<a href="#B25-preprints-107672" class="html-bibr">25</a>,<a href="#B26-preprints-107672" class="html-bibr">26</a>,<a href="#B27-preprints-107672" class="html-bibr">27</a>].</div> <div class="html-p">Although it is essential to remove the spike protein or a modified gene derived from the genetic vaccine if found in a blood product, currently, there is no reliable way to do so. The presence of a prion-like structure within the spike protein molecule [<a href="#B96-preprints-107672" class="html-bibr">96</a>,<a href="#B100-preprints-107672" class="html-bibr">100</a>,<a href="#B101-preprints-107672" class="html-bibr">101</a>] suggests that this molecule may be a persistent, sparingly soluble, heat-resistant, and radiation-resistant protein [<a href="#B132-preprints-107672" class="html-bibr">132</a>,<a href="#B133-preprints-107672" class="html-bibr">133</a>]. The prion protein can be inactivated by thiocyanate, hydroxide, and hypochlorite [<a href="#B134-preprints-107672" class="html-bibr">134</a>,<a href="#B135-preprints-107672" class="html-bibr">135</a>,<a href="#B136-preprints-107672" class="html-bibr">136</a>]; however, whether these methods can be applied to the spike protein and the resulting amyloid materials is not yet known. Notably, Nattokinase, an alkaline protease, degrades spike proteins <span class="html-italic">in vitro</span> [<a href="#B137-preprints-107672" class="html-bibr">137</a>]. Although further studies are needed to determine whether such enzymes are indeed effective in degrading spike proteins, it is worth noting that Nattokinase is already known as an alternative in the prevention and treatment of cardiovascular diseases [<a href="#B138-preprints-107672" class="html-bibr">138</a>,<a href="#B139-preprints-107672" class="html-bibr">139</a>,<a href="#B140-preprints-107672" class="html-bibr">140</a>]. Currently, however, there are no methods to reliably remove the pathogenic protein or mRNA; therefore, it might not be prudent to use all such blood products until a definitive solution is found. Some medical facilities might not be able to dispose of blood products immediately; therefore, in such cases, the transfusion consent form provided to the patient should include the possibility of blood products being contaminated with spike protein or other foreign substances. In any case, to prevent and reduce medical accidents caused by contaminated blood, it is imperative to underscore the importance of confirming the history and frequency of vaccination with genetic vaccines at the time of blood collection; this information should be documented as an official record, managed and stored by both medical and governmental organizations (see <a href="#preprints-107672-f002" class="html-fig">Figure 2</a>, <a href="#preprints-107672-t002" class="html-table">Table 2</a>).</div></section><section id="sec3dot3-preprints-107672" type><h4 class="html-italic" data-nested="2"> 3.3. Need for Regular Checkups and Cohort Studies to Gain a Complete Picture of Blood Components</h4> <div class="html-p">The residual status of spike protein or modified gene fragments derived from genetic vaccines in the blood of vaccinated individuals is currently unknown; it might be useful to include the measurement of these molecules in routine health checkups. It would also be prudent to include a section in the routine medical checkup questionnaire to check genetic vaccination status and the number of vaccinations received to obtain an overall picture of the residual status of spike proteins in the blood. A variety of conditions following genetic vaccination involve thrombosis and immunological conditions [<a href="#B12-preprints-107672" class="html-bibr">12</a>,<a href="#B14-preprints-107672" class="html-bibr">14</a>,<a href="#B16-preprints-107672" class="html-bibr">16</a>,<a href="#B17-preprints-107672" class="html-bibr">17</a>,<a href="#B21-preprints-107672" class="html-bibr">21</a>,<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B71-preprints-107672" class="html-bibr">71</a>,<a href="#B73-preprints-107672" class="html-bibr">73</a>]; therefore, abnormalities in blood components related to these events should also be analyzed.</div> <div class="html-p">Transmission of spike protein was observed when mice that had not been vaccinated with the genetic vaccine were administered exosomes collected from vaccine recipients [<a href="#B25-preprints-107672" class="html-bibr">25</a>], thus proving that the spike protein and its modified genes can be transmitted through exosomes. Therefore, full testing should be done initially, regardless of genetic vaccination status, and a cohort study should be conducted to quickly identify all components derived from genetic vaccines (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>). Although such measures involve steady, labor-intensive efforts that require collaboration between all parties involved, the subsequent analyses may lead to the development of diagnostic criteria and testing for COVID-19 PVS. In addition, even those individuals who have not been vaccinated with the genetic vaccine, but have had long COVID, may have residual spike proteins or fibrin-derived microthrombi in their bodies; therefore, the same testing and follow-up as that for genetic vaccine recipients should be conducted for such individuals. [<a href="#B52-preprints-107672" class="html-bibr">52</a>,<a href="#B53-preprints-107672" class="html-bibr">53</a>,<a href="#B113-preprints-107672" class="html-bibr">113</a>,<a href="#B114-preprints-107672" class="html-bibr">114</a>,<a href="#B115-preprints-107672" class="html-bibr">115</a>]. The presence or absence and amount of anti-nucleocapsid antibodies as well as that of antibody isotypes may be an indicator(s) in distinguishing whether vaccination with genetic vaccines or long COVID resulted in the presence of residual spike proteins or fibrin-derived microthrombi in their bodies (<a href="#preprints-107672-t002" class="html-table">Table 2</a>, point 10) [<a href="#B141-preprints-107672" class="html-bibr">141</a>,<a href="#B142-preprints-107672" class="html-bibr">142</a>,<a href="#B143-preprints-107672" class="html-bibr">143</a>]. Further, these cohort studies would help establish cutoff values for blood levels of spike protein and other substances to determine the safety of blood products. Faksova et al. conducted a large cohort study of 99 million people using a multinational Global Vaccine Data Network™ and found a significantly increased risk of myocarditis, pericarditis, Guillain-Barre syndrome, and cerebral venous sinus thrombosis in genetic vaccine recipients [<a href="#B144-preprints-107672" class="html-bibr">144</a>]. Such studies will be increasingly necessary in the future.</div></section><section id="sec3dot4-preprints-107672" type><h4 class="html-italic" data-nested="2"> 3.4. Need for Expedited Development of Clinical Practice Guidelines and Diagnostic Criteria for COVID-19 PVS</h4> <div class="html-p">Although the spectrum of COVID-19 PVS is diverse, it is mostly characterized by a high prevalence of hematologic and immune-related diseases [<a href="#B21-preprints-107672" class="html-bibr">21</a>]. Thus, regardless of the transfusion issues discussed in this paper, blood tests are likely to be the first step in the diagnosis of COVID-19 PVS. The ability to rapidly develop highly accurate testing systems, particularly blood tests, will be critical in treating patients with COVID-19 PVS. Additional meta-analysis of data from systematic reviews and cohort analyses will be needed to prevent bias in diagnostic criteria and to develop appropriate clinical practice guidelines (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>) [<a href="#B145-preprints-107672" class="html-bibr">145</a>,<a href="#B146-preprints-107672" class="html-bibr">146</a>,<a href="#B147-preprints-107672" class="html-bibr">147</a>].</div></section></section><section id="sec4-preprints-107672" type><h2 data-nested="1" id="preprints-h2-4"> 4. Effects of Blood Transfusion from Genetic Vaccine Recipients and the Need for Traceability of Blood Products for Transfusion</h2> <div class="html-p">There has been considerable debate regarding the safety of blood products for transfusion prepared from blood donated by vaccine recipients [<a href="#B36-preprints-107672" class="html-bibr">36</a>,<a href="#B37-preprints-107672" class="html-bibr">37</a>,<a href="#B38-preprints-107672" class="html-bibr">38</a>,<a href="#B39-preprints-107672" class="html-bibr">39</a>]. However, the effect of a genetic vaccine, such as an mRNA vaccine, on the human body is yet unknown, although cases of encephalitis caused by blood transfusion from dengue vaccine recipients have been reported as recently as 2023 [<a href="#B148-preprints-107672" class="html-bibr">148</a>], indicating that the current system for managing and tracking blood products is not adequate. Unless accurate tests are established, no conclusions can be drawn about the risk or safety of blood transfusions using blood products from genetic vaccine recipients. Therefore, thorough and continuous investigation is necessary, which can be accomplished by registering all potential donors, ensuring traceability of blood products, and maintaining rigorous recipient outcome studies and meta-analysis. Furthermore, it is essential to rigorously obtain a history of vaccination and COVID-19 infection from donors, preserve official records, and store samples of blood products for later detection and verification of substances such as spike proteins and exosomes (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>). Given the wide variety of tests and records, the movement of people around the world, and the import/export of blood products, it may be necessary in the future to establish traceability by introducing blockchain technology into the management of blood products while maintaining anonymity [<a href="#B149-preprints-107672" class="html-bibr">149</a>,<a href="#B150-preprints-107672" class="html-bibr">150</a>].</div></section><section id="sec5-preprints-107672" type><h2 data-nested="1" id="preprints-h2-5"> 5. Need for the Development of Relevant Legislation</h2> <div class="html-p">In Japan, the "Act on Prevention of Infectious Diseases and Medical Care for Patients with Infectious Diseases" (<a href="https://www.japaneselawtranslation.go.jp/en/laws/view/2830/en" target="_blank">https://www.japaneselawtranslation.go.jp/en/laws/view/2830/en</a>) and "Act on Organ Transplantation" have been enacted to prevent the spread of infectious diseases through blood products and to handle organ transplants, respectively. The Ministry of Health, Labour and Welfare has issued the "Guidelines for Blood Transfusion Therapy" regarding blood transfusions. These laws and guidelines specify the responsibilities of the public, physicians, and national and local governments and protect the rights of citizens. However, the spike protein, used as an antigen, or its gene, are not organisms; therefore, certain legal decisions are required, such as how to legally define the pathogenicity of the spike protein. Thus, a new definition of the spike protein—as a nonbiological infection, may be necessary with increasing clarity on its toxicity and pathogenicity [<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B62-preprints-107672" class="html-bibr">62</a>]. Subsequently, when the risks of and health injuries caused by blood products derived from genetic vaccination recipients have been roughly clarified (<a href="#preprints-107672-t002" class="html-table">Table 2</a>), it will be essential to formulate regulations to reduce and prevent risks and contamination. This can be achieved by developing related laws with the participation of the legislative branch, legal experts, medical administration personnel, healthcare providers, and medical researchers, and by taking measures such as checking vaccination status and dates and legally regulating the import/export of blood products (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>). The entire process requires coordination between agencies and healthcare professionals from the outset.</div> <div class="html-p">In contrast to previous drug programs, vaccination with genetic vaccines was implemented simultaneously for a substantial number of people on a global scale [<a href="#B2-preprints-107672" class="html-bibr">2</a>,<a href="#B3-preprints-107672" class="html-bibr">3</a>]; therefore, legislation and international treaties need to urgently and explicitly elucidate bilateral and multilateral agreements among countries regarding the management of blood products. These legal frameworks should delineate regulations governing the handling of blood products and establish protocols for governmental compensation and response to issues and hazards associated with these products, including penalties and prohibitions. The International Health Regulations 2005 [<a href="#B151-preprints-107672" class="html-bibr">151</a>,<a href="#B152-preprints-107672" class="html-bibr">152</a>] could be used for this purpose; however, considering the WHO's strong push for vaccination with genetic vaccines [<a href="#B153-preprints-107672" class="html-bibr">153</a>], another framework may be needed. As described in <a href="#sec3dot3-preprints-107672" class="html-sec">Section 3.3</a> of this article, it might also be necessary for countries to conduct active epidemiological surveys [<a href="#B154-preprints-107672" class="html-bibr">154</a>], as was the case with COVID-19, compile the results of these surveys, and establish an international organization tasked with monitoring response efforts and assessing damages within each country (<a href="#preprints-107672-f003" class="html-fig">Figure 3</a>). For such decisions, it is vital to incorporate not only the perspective of infectious diseases but also that of biosafety and biosecurity [<a href="#B152-preprints-107672" class="html-bibr">152</a>,<a href="#B155-preprints-107672" class="html-bibr">155</a>]. Thus, there is an urgent need for an international conference of various experts, including policymakers, legal experts, historians, and ethicists, to discuss in a transparent manner what problems and challenges might arise from genetic vaccines and beyond [<a href="#B156-preprints-107672" class="html-bibr">156</a>,<a href="#B157-preprints-107672" class="html-bibr">157</a>,<a href="#B158-preprints-107672" class="html-bibr">158</a>,<a href="#B159-preprints-107672" class="html-bibr">159</a>].</div> <div class="html-p">In Japan, Article 15 (2) of the Infectious Disease Act (<a href="https://www.japaneselawtranslation.go.jp/ja/laws/view/2830/en#je_ch3at5" target="_blank">https://www.japaneselawtranslation.go.jp/ja/laws/view/2830/en#je_ch3at5</a>) stipulates that the Japanese government is responsible for conducting epidemiological studies. Considering the significant health risks associated with COVID-19 PVS, we urge the Japanese government to prioritize the analysis and safety verification of blood products derived from genetic vaccine recipients.</div></section><section id="sec6-preprints-107672" type><h2 data-nested="1" id="preprints-h2-6"> 6. Further Considerations</h2> <div class="html-p">To address the need for developing methods to identify and remove spike proteins and modified genes derived from genetic vaccines from blood products, the Japanese Society of Hematology (<a href="http://www.jshem.or.jp/modules/en/index.php?content_id=1" target="_blank">http://www.jshem.or.jp/modules/en/index.php?content_id=1</a>), the Japanese Society of Transfusion and Cell Therapy (<a href="http://yuketsu.jstmct.or.jp/en/" target="_blank">http://yuketsu.jstmct.or.jp/en/</a>), and related organizations need to develop guidelines on how to handle blood products that contain residual spike proteins or their modified genes ensuring that a uniform inspection standard is developed. Additionally, as noted earlier, vaccination with genetic vaccines has been promoted on a global scale [<a href="#B2-preprints-107672" class="html-bibr">2</a>,<a href="#B3-preprints-107672" class="html-bibr">3</a>], which will necessitate coordination and exchange of information with national administrations and relevant international medical societies (<a href="#preprints-107672-f002" class="html-fig">Figure 2</a>). Furthermore, international guidelines on the handling of blood products and the establishment of an international investigatory organization will be necessary (<a href="#preprints-107672-f003" class="html-fig">Figure 3</a>). There is an urgent need to share the risks of transfusion of blood products derived from genetic vaccine recipients among the parties concerned, and prompt investigation and response by all parties concerned is essential. </div> <div class="html-p">During the course of the development of various guidelines, previous responses to such health emergencies should be considered; for example, when the transmission of BSE and vCJD, also through blood transfusion, was a health issue (e.g., the Creutzfeldt-Jakob Disease International Surveillance Network in <a href="https://www.eurocjd.ed.ac.uk/" target="_blank">https://www.eurocjd.ed.ac.uk/</a>) [<a href="#B105-preprints-107672" class="html-bibr">105</a>,<a href="#B116-preprints-107672" class="html-bibr">116</a>,<a href="#B117-preprints-107672" class="html-bibr">117</a>,<a href="#B123-preprints-107672" class="html-bibr">123</a>,<a href="#B160-preprints-107672" class="html-bibr">160</a>]. In the case of BSE in the United Kingdom, the mode of transmission of prion protein was unknown; therefore, leukodepletion of blood products was conducted universally. Whether this action was effective in preventing transmission of BSE and vCJD through blood products is controversial [<a href="#B105-preprints-107672" class="html-bibr">105</a>,<a href="#B122-preprints-107672" class="html-bibr">122</a>,<a href="#B123-preprints-107672" class="html-bibr">123</a>,<a href="#B161-preprints-107672" class="html-bibr">161</a>]; however, removing white blood cells from all blood products was not common at that time, as is now routinely done with collected blood. Nevertheless, because of leukodepletion, the safety of blood products has increased [<a href="#B162-preprints-107672" class="html-bibr">162</a>]. In the case of the spike protein, which causes abnormalities such as agglutination of red blood cells and platelets [<a href="#B8-preprints-107672" class="html-bibr">8</a>,<a href="#B9-preprints-107672" class="html-bibr">9</a>,<a href="#B10-preprints-107672" class="html-bibr">10</a>,<a href="#B11-preprints-107672" class="html-bibr">11</a>,<a href="#B50-preprints-107672" class="html-bibr">50</a>], leukodepletion alone will not resolve the issue. Thus, it is worth confirming whether washing of red blood cells can be effective [<a href="#B163-preprints-107672" class="html-bibr">163</a>,<a href="#B164-preprints-107672" class="html-bibr">164</a>]; in urgent cases, autotransfusion may be an option [<a href="#B165-preprints-107672" class="html-bibr">165</a>].</div> <div class="html-p">Recent studies have shown that RNA pseudouridylation can result in frameshifting [<a href="#B166-preprints-107672" class="html-bibr">166</a>]; however, whether a portion of the pseudouridinated mRNA for the spike protein is translated into another protein of unknown function in vaccine recipients is yet unknown. Moreover, if these proteins are also pathogenic, additional testing for such frameshift proteins may be needed in the future. Even if a frameshift protein is not toxic, it is foreign to the body and could cause an autoimmune reaction. In addition, as described in <a href="#sec3dot1-preprints-107672" class="html-sec">Section 3.1</a>, LNPs themselves are highly inflammatory substances [<a href="#B23-preprints-107672" class="html-bibr">23</a>,<a href="#B106-preprints-107672" class="html-bibr">106</a>,<a href="#B107-preprints-107672" class="html-bibr">107</a>,<a href="#B109-preprints-107672" class="html-bibr">109</a>,<a href="#B110-preprints-107672" class="html-bibr">110</a>]; however, LNPs exhibit stronger adjuvant activity than the adjuvants used in conventional vaccines [<a href="#B167-preprints-107672" class="html-bibr">167</a>], and could result in autoimmune diseases (<a href="#preprints-107672-t001" class="html-table">Table 1</a>, point 4) [<a href="#B168-preprints-107672" class="html-bibr">168</a>,<a href="#B169-preprints-107672" class="html-bibr">169</a>]. Thus, although the causative agent of autoimmune disease is not yet known, the large number of reported cases of autoimmune disease following genetic vaccination is a concern [<a href="#B15-preprints-107672" class="html-bibr">15</a>,<a href="#B21-preprints-107672" class="html-bibr">21</a>,<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B30-preprints-107672" class="html-bibr">30</a>,<a href="#B169-preprints-107672" class="html-bibr">169</a>,<a href="#B170-preprints-107672" class="html-bibr">170</a>]. The very mechanism of genetic vaccines that induces one's own cells to produce antigens of the pathogen carries the risk of inducing autoimmune diseases, which cannot be completely avoided even if mRNA pseudouridylation technology is used. Thus, individuals with a positive blood test for spike protein may need to undergo interviews and additional tests for autoimmune disease indicators, such as for antinuclear antibodies (<a href="#preprints-107672-t002" class="html-table">Table 2</a>, point 4) [<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B169-preprints-107672" class="html-bibr">169</a>,<a href="#B171-preprints-107672" class="html-bibr">171</a>,<a href="#B172-preprints-107672" class="html-bibr">172</a>]. Alternatively, if the amino acid sequence of the protein resulting from such a frameshift is predictable, these candidate proteins could be included in the initial mass spectrometry assay (<a href="#preprints-107672-t002" class="html-table">Table 2</a>, point 6). Thus, it is particularly important to develop tests and establish medical care settings in anticipation of these situations.</div></section><section id="sec7-preprints-107672" type><h2 data-nested="1" id="preprints-h2-7"> 7. Conclusion</h2> <div class="html-p">Finally, the use of genetic vaccines, such as pseudouridinated mRNAs and mRNA-LNP platforms [<a href="#B47-preprints-107672" class="html-bibr">47</a>,<a href="#B108-preprints-107672" class="html-bibr">108</a>], should be reviewed critically to avoid further risks similar to those described in this paper. The impact of these genetic vaccines on blood products and the actual damage caused by them are unknown at present. Furthermore, the issues discussed in this paper pertain to all organ transplants, including bone marrow transplants, and not just blood products. Therefore, in order to avoid these risks and prevent further expansion of the potential for blood contamination and complication of the situation, we suggest that the vaccination campaign using genetic vaccines should proceed with caution and that a harm–benefit assessment be carried out, as called for by Fraiman et al. and Polykretis et al. [<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B31-preprints-107672" class="html-bibr">31</a>,<a href="#B32-preprints-107672" class="html-bibr">32</a>,<a href="#B33-preprints-107672" class="html-bibr">33</a>]. Moreover, as Parry et al. stated [<a href="#B22-preprints-107672" class="html-bibr">22</a>], it is critical and timely to reevaluate the pseudouridinated mRNA based technology before the advent of other genetic vaccines that are being developed. The health injuries caused by vaccination with genetic vaccines cannot be ignored; therefore, countries and relevant organizations should take concrete steps together to identify the risks and to control and resolve them.</div></section> <section class="html-notes"><h2 id="preprints-h2-8">Author Contributions</h2> <div class="html-p">Conceptualization, J.U., M.F. and A.F.; investigation, J.U., H.M., Y.M., M.F. and A.F.; resources, Y.H.; data curation, J.U., H.M., M.F. and A.F.; writing—original draft preparation, J.U.; writing—review and editing, J.U., H.M., Y.H., K.Y., Y.M., M.F. and A.F.; visualization, J.U.; supervision, J.U., M.F. and A.F.; project administration, J.U., M.F. and A.F. All authors have read and agreed to the published version of the manuscript.</div></section><section class="html-notes"><h2 id="preprints-h2-9">Funding</h2> <div class="html-p">This research received no external funding.</div></section><section class="html-notes"><h2 id="preprints-h2-10">Institutional Review Board Statement</h2> <div class="html-p">Not applicable.</div></section><section class="html-notes"><h2 id="preprints-h2-11">Conflicts of Interest</h2> <div class="html-p">The authors declare no conflict of interest in connection with this research.</div></section><section id="html-references_list"><h2 id="preprints-h2-12">References</h2> <ol class="html-xxx"> <li id="B1-preprints-107672" class="html-x" data-content="1.">Sohrabi, C.; Alsafi, Z.; O'Neill, N.; Khan, M.; Kerwan, A.; Al-Jabir, A.; Iosifidis, C.; Agha, R. , World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). <span class="html-italic">International Journal of Surgery</span> <b>2020</b>, <span class="html-italic">76</span>, 71–76. [<a href="https://scholar.google.com/scholar_lookup?title=,+World+Health+Organization+declares+global+emergency:+A+review+of+the+2019+novel+coronavirus+(COVID-19)&author=Sohrabi,+C.&author=Alsafi,+Z.&author=O'Neill,+N.&author=Khan,+M.&author=Kerwan,+A.&author=Al-Jabir,+A.&author=Iosifidis,+C.&author=Agha,+R.&publication_year=2020&journal=International+Journal+of+Surgery&volume=76&pages=71%E2%80%9376&doi=10.1016/j.ijsu.2020.02.034&pmid=32112977" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ijsu.2020.02.034" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/32112977" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B2-preprints-107672" class="html-x" data-content="2.">Francis, A. I.; Ghany, S.; Gilkes, T.; Umakanthan, S. , Review of COVID-19 vaccine subtypes, efficacy and geographical distributions. <span class="html-italic">Postgraduate Medical Journal</span> <b>2022</b>, <span class="html-italic">98</span>, 389–94. [<a href="https://scholar.google.com/scholar_lookup?title=,+Review+of+COVID-19+vaccine+subtypes,+efficacy+and+geographical+distributions&author=Francis,+A.+I.&author=Ghany,+S.&author=Gilkes,+T.&author=Umakanthan,+S.&publication_year=2022&journal=Postgraduate+Medical+Journal&volume=98&pages=389%E2%80%9394&doi=10.1136/postgradmedj-2021-140654&pmid=37066438" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1136/postgradmedj-2021-140654" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/37066438" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B3-preprints-107672" class="html-x" data-content="3.">Patel, R.; Kaki, M.; Potluri, V. S.; Kahar, P.; Khanna, D. , A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & Johnson. <span class="html-italic">Human Vaccines & Immunotherapeutics 2022, 18</span>.</li> <li id="B4-preprints-107672" class="html-x" data-content="4.">Harrison, A. G.; Lin, T.; Wang, P. , Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. <span class="html-italic">Trends in Immunology</span> <b>2020</b>, <span class="html-italic">41</span>, 1100–15. [<a href="https://scholar.google.com/scholar_lookup?title=,+Mechanisms+of+SARS-CoV-2+Transmission+and+Pathogenesis&author=Harrison,+A.+G.&author=Lin,+T.&author=Wang,+P.&publication_year=2020&journal=Trends+in+Immunology&volume=41&pages=1100%E2%80%9315&doi=10.1016/j.it.2020.10.004&pmid=33132005" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.it.2020.10.004" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33132005" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B5-preprints-107672" class="html-x" data-content="5.">Lamers, M. M.; Haagmans, B. L. , SARS-CoV-2 pathogenesis. <span class="html-italic">Nature Reviews Microbiology</span> <b>2022</b>, <span class="html-italic">20</span>, 270–84. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+pathogenesis&author=Lamers,+M.+M.&author=Haagmans,+B.+L.&publication_year=2022&journal=Nature+Reviews+Microbiology&volume=20&pages=270%E2%80%9384&doi=10.1038/s41579-022-00713-0&pmid=35354968" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41579-022-00713-0" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35354968" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B6-preprints-107672" class="html-x" data-content="6.">Lan, J.; Ge, J.; Yu, J.; Shan, S.; Zhou, H.; Fan, S.; Zhang, Q.; Shi, X.; Wang, Q.; Zhang, L.; Wang, X. , Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. <span class="html-italic">Nature</span> <b>2020</b>, <span class="html-italic">581</span>, 215–20. [<a href="https://scholar.google.com/scholar_lookup?title=,+Structure+of+the+SARS-CoV-2+spike+receptor-binding+domain+bound+to+the+ACE2+receptor&author=Lan,+J.&author=Ge,+J.&author=Yu,+J.&author=Shan,+S.&author=Zhou,+H.&author=Fan,+S.&author=Zhang,+Q.&author=Shi,+X.&author=Wang,+Q.&author=Zhang,+L.&publication_year=2020&journal=Nature&volume=581&pages=215%E2%80%9320&doi=10.1038/s41586-020-2180-5" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41586-020-2180-5" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B7-preprints-107672" class="html-x" data-content="7.">Zhang, S.; Liu, Y.; Wang, X.; Yang, L.; Li, H.; Wang, Y.; Liu, M.; Zhao, X.; Xie, Y.; Yang, Y.; Zhang, S.; Fan, Z.; Dong, J.; Yuan, Z.; Ding, Z.; Zhang, Y.; Hu, L. , SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. <span class="html-italic">Journal of Hematology & Oncology 2020, 13</span>.</li> <li id="B8-preprints-107672" class="html-x" data-content="8.">Berzuini, A.; Bianco, C.; Migliorini, A. C.; Maggioni, M.; Valenti, L.; Prati, D. , Red blood cell morphology in patients with COVID-19-related anaemia. <span class="html-italic">Blood Transfus</span> <b>2021</b>, <span class="html-italic">19</span>, 34–36. [<a href="https://scholar.google.com/scholar_lookup?title=,+Red+blood+cell+morphology+in+patients+with+COVID-19-related+anaemia&author=Berzuini,+A.&author=Bianco,+C.&author=Migliorini,+A.+C.&author=Maggioni,+M.&author=Valenti,+L.&author=Prati,+D.&publication_year=2021&journal=Blood+Transfus&volume=19&pages=34%E2%80%9336&pmid=32955421" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/32955421" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B9-preprints-107672" class="html-x" data-content="9.">Melkumyants, A.; Buryachkovskaya, L.; Lomakin, N.; Antonova, O.; Serebruany, V. , Mild COVID-19 and Impaired Blood Cell–Endothelial Crosstalk: Considering Long-Term Use of Antithrombotics? <span class="html-italic">Thrombosis and Haemostasis</span> <b>2021</b>, <span class="html-italic">122</span>, 123–30. [<a href="https://scholar.google.com/scholar_lookup?title=,+Mild+COVID-19+and+Impaired+Blood+Cell%E2%80%93Endothelial+Crosstalk:+Considering+Long-Term+Use+of+Antithrombotics?&author=Melkumyants,+A.&author=Buryachkovskaya,+L.&author=Lomakin,+N.&author=Antonova,+O.&author=Serebruany,+V.&publication_year=2021&journal=Thrombosis+and+Haemostasis&volume=122&pages=123%E2%80%9330&doi=10.1055/a-1551-9911" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1055/a-1551-9911" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B10-preprints-107672" class="html-xx" data-content="10.">Boschi, C.; Scheim, D. E.; Bancod, A.; Militello, M.; Bideau, M. L.; Colson, P.; Fantini, J.; Scola, B. L. , SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects. <span class="html-italic">International Journal of Molecular Sciences</span> <b>2022</b>, 23. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Spike+Protein+Induces+Hemagglutination:+Implications+for+COVID-19+Morbidities+and+Therapeutics+and+for+Vaccine+Adverse+Effects&author=Boschi,+C.&author=Scheim,+D.+E.&author=Bancod,+A.&author=Militello,+M.&author=Bideau,+M.+L.&author=Colson,+P.&author=Fantini,+J.&author=Scola,+B.+L.&publication_year=2022&journal=International+Journal+of+Molecular+Sciences&pages=23&doi=10.3390/ijms232415480" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/ijms232415480" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B11-preprints-107672" class="html-xx" data-content="11.">Scheim, D. E. , A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody. <span class="html-italic">International Journal of Molecular Sciences</span> <b>2022</b>, 23. [<a href="https://scholar.google.com/scholar_lookup?title=,+A+Deadly+Embrace:+Hemagglutination+Mediated+by+SARS-CoV-2+Spike+Protein+at+Its+22+N-Glycosylation+Sites,+Red+Blood+Cell+Surface+Sialoglycoproteins,+and+Antibody&author=Scheim,+D.+E.&publication_year=2022&journal=International+Journal+of+Molecular+Sciences&pages=23&doi=10.3390/ijms23052558" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/ijms23052558" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B12-preprints-107672" class="html-xx" data-content="12.">McFadyen, J. D.; Stevens, H.; Peter, K. , The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications. <span class="html-italic">Circulation Research</span> <b>2020</b>, <span class="html-italic">127</span>, 571–87. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+Emerging+Threat+of+(Micro)Thrombosis+in+COVID-19+and+Its+Therapeutic+Implications&author=McFadyen,+J.+D.&author=Stevens,+H.&author=Peter,+K.&publication_year=2020&journal=Circulation+Research&volume=127&pages=571%E2%80%9387&doi=10.1161/CIRCRESAHA.120.317447" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1161/CIRCRESAHA.120.317447" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B13-preprints-107672" class="html-xx" data-content="13.">13. Grobbelaar, Lize M.; Venter, C.; Vlok, M.; Ngoepe, M.; Laubscher, Gert J.; Lourens, Petrus J.; Steenkamp, J.; Kell, Douglas B.; Pretorius, E., SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. <span class="html-italic">Bioscience Reports 2021, 41</span>.</li> <li id="B14-preprints-107672" class="html-xx" data-content="14.">Bilotta, C.; Perrone, G.; Adelfio, V.; Spatola, G. F.; Uzzo, M. L.; Argo, A.; Zerbo, S. , COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis. <span class="html-italic">Front Immunol</span> <b>2021</b>, <span class="html-italic">12</span>, 729251. [<a href="https://scholar.google.com/scholar_lookup?title=,+COVID-19+Vaccine-Related+Thrombosis:+A+Systematic+Review+and+Exploratory+Analysis&author=Bilotta,+C.&author=Perrone,+G.&author=Adelfio,+V.&author=Spatola,+G.+F.&author=Uzzo,+M.+L.&author=Argo,+A.&author=Zerbo,+S.&publication_year=2021&journal=Front+Immunol&volume=12&pages=729251&doi=10.3389/fimmu.2021.729251&pmid=34912330" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3389/fimmu.2021.729251" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34912330" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B15-preprints-107672" class="html-xx" data-content="15.">Garg, R. K.; Paliwal, V. K. , Spectrum of neurological complications following COVID-19 vaccination. <span class="html-italic">Neurological Sciences</span> <b>2021</b>, <span class="html-italic">43</span>, 3–40. [<a href="https://scholar.google.com/scholar_lookup?title=,+Spectrum+of+neurological+complications+following+COVID-19+vaccination&author=Garg,+R.+K.&author=Paliwal,+V.+K.&publication_year=2021&journal=Neurological+Sciences&volume=43&pages=3%E2%80%9340&doi=10.1007/s10072-021-05662-9&pmid=34719776" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1007/s10072-021-05662-9" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34719776" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B16-preprints-107672" class="html-xx" data-content="16.">Oldenburg, J.; Klamroth, R.; Langer, F.; Albisetti, M.; von Auer, C.; Ay, C.; Korte, W.; Scharf, R. E.; Pötzsch, B.; Greinacher, A. , Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH. <span class="html-italic">Hämostaseologie 2021, 41, (03), 184-89</span>.</li> <li id="B17-preprints-107672" class="html-xx" data-content="17.">Sharifian-Dorche, M.; Bahmanyar, M.; Sharifian-Dorche, A.; Mohammadi, P.; Nomovi, M.; Mowla, A. , Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review. <span class="html-italic">J Neurol Sci</span> <b>2021</b>, <span class="html-italic">428</span>, 117607. [<a href="https://scholar.google.com/scholar_lookup?title=,+Vaccine-induced+immune+thrombotic+thrombocytopenia+and+cerebral+venous+sinus+thrombosis+post+COVID-19+vaccination;+a+systematic+review&author=Sharifian-Dorche,+M.&author=Bahmanyar,+M.&author=Sharifian-Dorche,+A.&author=Mohammadi,+P.&author=Nomovi,+M.&author=Mowla,+A.&publication_year=2021&journal=J+Neurol+Sci&volume=428&pages=117607&doi=10.1016/j.jns.2021.117607&pmid=34365148" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.jns.2021.117607" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34365148" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B18-preprints-107672" class="html-xx" data-content="18.">Lane, S.; Yeomans, A.; Shakir, S. , Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: a systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature. <span class="html-italic">BMJ Open</span> <b>2022</b>, 12. [<a href="https://scholar.google.com/scholar_lookup?title=,+Reports+of+myocarditis+and+pericarditis+following+mRNA+COVID-19+vaccination:+a+systematic+review+of+spontaneously+reported+data+from+the+UK,+Europe+and+the+USA+and+of+the+scientific+literature&author=Lane,+S.&author=Yeomans,+A.&author=Shakir,+S.&publication_year=2022&journal=BMJ+Open&pages=12&doi=10.1136/bmjopen-2021-059223&pmid=35613761" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1136/bmjopen-2021-059223" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35613761" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B19-preprints-107672" class="html-xx" data-content="19.">Oster, M. E.; Shay, D. K.; Su, J. R.; Gee, J.; Creech, C. B.; Broder, K. R.; Edwards, K.; Soslow, J. H.; Dendy, J. M.; Schlaudecker, E.; Lang, S. M.; Barnett, E. D.; Ruberg, F. L.; Smith, M. J.; Campbell, M. J.; Lopes, R. D.; Sperling, L. S.; Baumblatt, J. A.; Thompson, D. L.; Marquez, P. L.; Strid, P.; Woo, J.; Pugsley, R.; Reagan-Steiner, S.; DeStefano, F.; Shimabukuro, T. T. , Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021. <span class="html-italic">Jama</span> <b>2022</b>, 327. [<a href="https://scholar.google.com/scholar_lookup?title=,+Myocarditis+Cases+Reported+After+mRNA-Based+COVID-19+Vaccination+in+the+US+From+December+2020+to+August+2021&author=Oster,+M.+E.&author=Shay,+D.+K.&author=Su,+J.+R.&author=Gee,+J.&author=Creech,+C.+B.&author=Broder,+K.+R.&author=Edwards,+K.&author=Soslow,+J.+H.&author=Dendy,+J.+M.&author=Schlaudecker,+E.&publication_year=2022&journal=Jama&pages=327&doi=10.1001/jama.2021.24110&pmid=35076665" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1001/jama.2021.24110" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35076665" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B20-preprints-107672" class="html-xx" data-content="20.">Yasmin, F.; Najeeb, H.; Naeem, U.; Moeed, A.; Atif, A. R.; Asghar, M. S.; Nimri, N.; Saleem, M.; Bandyopadhyay, D.; Krittanawong, C.; Fadelallah Eljack, M. M.; Tahir, M. J.; Waqar, F. , Adverse events following COVID-19 mRNA vaccines: A systematic review of cardiovascular complication, thrombosis, and thrombocytopenia. <span class="html-italic">Immun Inflamm Dis</span> <b>2023</b>, <span class="html-italic">11</span>, e807. [<a href="https://scholar.google.com/scholar_lookup?title=,+Adverse+events+following+COVID-19+mRNA+vaccines:+A+systematic+review+of+cardiovascular+complication,+thrombosis,+and+thrombocytopenia&author=Yasmin,+F.&author=Najeeb,+H.&author=Naeem,+U.&author=Moeed,+A.&author=Atif,+A.+R.&author=Asghar,+M.+S.&author=Nimri,+N.&author=Saleem,+M.&author=Bandyopadhyay,+D.&author=Krittanawong,+C.&publication_year=2023&journal=Immun+Inflamm+Dis&volume=11&pages=e807&doi=10.1002/iid3.807&pmid=36988252" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1002/iid3.807" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36988252" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B21-preprints-107672" class="html-xx" data-content="21.">Konishi, N.; Hirai, Y.; Hikota, H.; Miyahara, S.; Fujisawa, A.; Motohashi, H.; Ueda, J.; Inoue, M.; Fukushima, M. , Quantifying side effects of COVID-19 vaccines: A PubMed survey of papers on diseases as side effects presented at academic conferences in Japan. Rinsho Hyoka (Clinical Evaluation) 2024; 51. [<a href="https://scholar.google.com/scholar_lookup?title=,+Quantifying+side+effects+of+COVID-19+vaccines:+A+PubMed+survey+of+papers+on+diseases+as+side+effects+presented+at+academic+conferences+in+Japan&conference=Rinsho+Hyoka+(Clinical+Evaluation)+2024&author=Konishi,+N.&author=Hirai,+Y.&author=Hikota,+H.&author=Miyahara,+S.&author=Fujisawa,+A.&author=Motohashi,+H.&author=Ueda,+J.&author=Inoue,+M.&author=Fukushima,+M.&publication_year=51" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>]</li> <li id="B22-preprints-107672" class="html-xx" data-content="22.">Parry, P. I.; Lefringhausen, A.; Turni, C.; Neil, C. J.; Cosford, R.; Hudson, N. J.; Gillespie, J. , ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA. <span class="html-italic">Biomedicines</span> <b>2023</b>, 11. [<a href="https://scholar.google.com/scholar_lookup?title=,+%E2%80%98Spikeopathy%E2%80%99:+COVID-19+Spike+Protein+Is+Pathogenic,+from+Both+Virus+and+Vaccine+mRNA&author=Parry,+P.+I.&author=Lefringhausen,+A.&author=Turni,+C.&author=Neil,+C.+J.&author=Cosford,+R.&author=Hudson,+N.+J.&author=Gillespie,+J.&publication_year=2023&journal=Biomedicines&pages=11&doi=10.3390/biomedicines11082287&pmid=37626783" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/biomedicines11082287" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/37626783" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B23-preprints-107672" class="html-xx" data-content="23.">Ndeupen, S.; Qin, Z.; Jacobsen, S.; Bouteau, A.; Estanbouli, H.; Igyártó, B. Z. , The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. <span class="html-italic">iScience</span> <b>2021</b>, 24. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+mRNA-LNP+platform's+lipid+nanoparticle+component+used+in+preclinical+vaccine+studies+is+highly+inflammatory&author=Ndeupen,+S.&author=Qin,+Z.&author=Jacobsen,+S.&author=Bouteau,+A.&author=Estanbouli,+H.&author=Igy%C3%A1rt%C3%B3,+B.+Z.&publication_year=2021&journal=iScience&pages=24" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>]</li> <li id="B24-preprints-107672" class="html-xx" data-content="24.">Maugeri, M.; Nawaz, M.; Papadimitriou, A.; Angerfors, A.; Camponeschi, A.; Na, M.; Hölttä, M.; Skantze, P.; Johansson, S.; Sundqvist, M.; Lindquist, J.; Kjellman, T.; Mårtensson, I.-L.; Jin, T.; Sunnerhagen, P.; Östman, S.; Lindfors, L.; Valadi, H. , Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells. <span class="html-italic">Nature Communications</span> <b>2019</b>, 10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Linkage+between+endosomal+escape+of+LNP-mRNA+and+loading+into+EVs+for+transport+to+other+cells&author=Maugeri,+M.&author=Nawaz,+M.&author=Papadimitriou,+A.&author=Angerfors,+A.&author=Camponeschi,+A.&author=Na,+M.&author=H%C3%B6ltt%C3%A4,+M.&author=Skantze,+P.&author=Johansson,+S.&author=Sundqvist,+M.&publication_year=2019&journal=Nature+Communications&pages=10&doi=10.1038/s41467-019-12275-6" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41467-019-12275-6" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B25-preprints-107672" class="html-xx" data-content="25.">Bansal, S.; Perincheri, S.; Fleming, T.; Poulson, C.; Tiffany, B.; Bremner, R. M.; Mohanakumar, T. , Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines. <span class="html-italic">The Journal of Immunology</span> <b>2021</b>, <span class="html-italic">207</span>, 2405–10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Cutting+Edge:+Circulating+Exosomes+with+COVID+Spike+Protein+Are+Induced+by+BNT162b2+(Pfizer%E2%80%93BioNTech)+Vaccination+prior+to+Development+of+Antibodies:+A+Novel+Mechanism+for+Immune+Activation+by+mRNA+Vaccines&author=Bansal,+S.&author=Perincheri,+S.&author=Fleming,+T.&author=Poulson,+C.&author=Tiffany,+B.&author=Bremner,+R.+M.&author=Mohanakumar,+T.&publication_year=2021&journal=The+Journal+of+Immunology&volume=207&pages=2405%E2%80%9310&doi=10.4049/jimmunol.2100637" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.4049/jimmunol.2100637" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B26-preprints-107672" class="html-xx" data-content="26.">Seneff, S.; Nigh, G.; Kyriakopoulos, A. M.; McCullough, P. A. , Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. <span class="html-italic">Food Chem Toxicol</span> <b>2022</b>, <span class="html-italic">164</span>, 113008. [<a href="https://scholar.google.com/scholar_lookup?title=,+Innate+immune+suppression+by+SARS-CoV-2+mRNA+vaccinations:+The+role+of+G-quadruplexes,+exosomes,+and+MicroRNAs&author=Seneff,+S.&author=Nigh,+G.&author=Kyriakopoulos,+A.+M.&author=McCullough,+P.+A.&publication_year=2022&journal=Food+Chem+Toxicol&volume=164&pages=113008&doi=10.1016/j.fct.2022.113008" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.fct.2022.113008" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B27-preprints-107672" class="html-xx" data-content="27.">Polykretis, P.; Donzelli, A.; Lindsay, J. C.; Wiseman, D.; Kyriakopoulos, A. M.; Mörz, M.; Bellavite, P.; Fukushima, M.; Seneff, S.; McCullough, P. A. , Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues. <span class="html-italic">Autoimmunity</span> <b>2023</b>, 56. [<a href="https://scholar.google.com/scholar_lookup?title=,+Autoimmune+inflammatory+reactions+triggered+by+the+COVID-19+genetic+vaccines+in+terminally+differentiated+tissues&author=Polykretis,+P.&author=Donzelli,+A.&author=Lindsay,+J.+C.&author=Wiseman,+D.&author=Kyriakopoulos,+A.+M.&author=M%C3%B6rz,+M.&author=Bellavite,+P.&author=Fukushima,+M.&author=Seneff,+S.&author=McCullough,+P.+A.&publication_year=2023&journal=Autoimmunity&pages=56&doi=10.1080/08916934.2023.2259123&pmid=37710966" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1080/08916934.2023.2259123" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/37710966" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B28-preprints-107672" class="html-xx" data-content="28.">Brogna, C.; Cristoni, S.; Marino, G.; Montano, L.; Viduto, V.; Fabrowski, M.; Lettieri, G.; Piscopo, M. , Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS-CoV-2: Possible molecular mechanisms. <span class="html-italic">Proteomics Clin Appl</span> <b>2023</b>, <span class="html-italic">17</span>, e2300048. [<a href="https://scholar.google.com/scholar_lookup?title=,+Detection+of+recombinant+Spike+protein+in+the+blood+of+individuals+vaccinated+against+SARS-CoV-2:+Possible+molecular+mechanisms&author=Brogna,+C.&author=Cristoni,+S.&author=Marino,+G.&author=Montano,+L.&author=Viduto,+V.&author=Fabrowski,+M.&author=Lettieri,+G.&author=Piscopo,+M.&publication_year=2023&journal=Proteomics+Clin+Appl&volume=17&pages=e2300048&doi=10.1002/prca.202300048&pmid=37650258" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1002/prca.202300048" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/37650258" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B29-preprints-107672" class="html-xx" data-content="29.">Yonker, L. M.; Swank, Z.; Bartsch, Y. C.; Burns, M. D.; Kane, A.; Boribong, B. P.; Davis, J. P.; Loiselle, M.; Novak, T.; Senussi, Y.; Cheng, C. A.; Burgess, E.; Edlow, A. G.; Chou, J.; Dionne, A.; Balaguru, D.; Lahoud-Rahme, M.; Arditi, M.; Julg, B.; Randolph, A. G.; Alter, G.; Fasano, A.; Walt, D. R. , Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. <span class="html-italic">Circulation</span> <b>2023</b>, <span class="html-italic">147</span>, 867–76. [<a href="https://scholar.google.com/scholar_lookup?title=,+Circulating+Spike+Protein+Detected+in+Post-COVID-19+mRNA+Vaccine+Myocarditis&author=Yonker,+L.+M.&author=Swank,+Z.&author=Bartsch,+Y.+C.&author=Burns,+M.+D.&author=Kane,+A.&author=Boribong,+B.+P.&author=Davis,+J.+P.&author=Loiselle,+M.&author=Novak,+T.&author=Senussi,+Y.&publication_year=2023&journal=Circulation&volume=147&pages=867%E2%80%9376&doi=10.1161/CIRCULATIONAHA.122.061025" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1161/CIRCULATIONAHA.122.061025" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B30-preprints-107672" class="html-xx" data-content="30.">Chen, Y.; Xu, Z.; Wang, P.; Li, X. M.; Shuai, Z. W.; Ye, D. Q.; Pan, H. F. , New-onset autoimmune phenomena post-COVID-19 vaccination. <span class="html-italic">Immunology</span> <b>2022</b>, <span class="html-italic">165</span>, 386–401. [<a href="https://scholar.google.com/scholar_lookup?title=,+New-onset+autoimmune+phenomena+post-COVID-19+vaccination&author=Chen,+Y.&author=Xu,+Z.&author=Wang,+P.&author=Li,+X.+M.&author=Shuai,+Z.+W.&author=Ye,+D.+Q.&author=Pan,+H.+F.&publication_year=2022&journal=Immunology&volume=165&pages=386%E2%80%93401&doi=10.1111/imm.13443&pmid=34957554" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/imm.13443" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34957554" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B31-preprints-107672" class="html-xx" data-content="31.">Polykretis, P.; McCullough, P. A. , Rational harm-benefit assessments by age group are required for continued COVID-19 vaccination. <span class="html-italic">Scandinavian Journal of Immunology</span> <b>2022</b>, 98. [<a href="https://scholar.google.com/scholar_lookup?title=,+Rational+harm-benefit+assessments+by+age+group+are+required+for+continued+COVID-19+vaccination&author=Polykretis,+P.&author=McCullough,+P.+A.&publication_year=2022&journal=Scandinavian+Journal+of+Immunology&pages=98&doi=10.1111/sji.13242&pmid=38441161" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/sji.13242" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/38441161" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B32-preprints-107672" class="html-xx" data-content="32.">Fraiman, J.; Erviti, J.; Jones, M.; Greenland, S.; Whelan, P.; Kaplan, R. M.; Doshi, P. , Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. <span class="html-italic">Vaccine</span> <b>2022</b>, <span class="html-italic">40</span>, 5798–805. [<a href="https://scholar.google.com/scholar_lookup?title=,+Serious+adverse+events+of+special+interest+following+mRNA+COVID-19+vaccination+in+randomized+trials+in+adults&author=Fraiman,+J.&author=Erviti,+J.&author=Jones,+M.&author=Greenland,+S.&author=Whelan,+P.&author=Kaplan,+R.+M.&author=Doshi,+P.&publication_year=2022&journal=Vaccine&volume=40&pages=5798%E2%80%93805&doi=10.1016/j.vaccine.2022.08.036&pmid=36055877" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.vaccine.2022.08.036" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36055877" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B33-preprints-107672" class="html-xx" data-content="33.">Bardosh, K.; Krug, A.; Jamrozik, E.; Lemmens, T.; Keshavjee, S.; Prasad, V.; Makary, M. A.; Baral, S.; Høeg, T. B. , COVID-19 vaccine boosters for young adults: a risk benefit assessment and ethical analysis of mandate policies at universities. <span class="html-italic">Journal of Medical Ethics</span> <b>2024</b>, <span class="html-italic">50</span>, 126–38. [<a href="https://scholar.google.com/scholar_lookup?title=,+COVID-19+vaccine+boosters+for+young+adults:+a+risk+benefit+assessment+and+ethical+analysis+of+mandate+policies+at+universities&author=Bardosh,+K.&author=Krug,+A.&author=Jamrozik,+E.&author=Lemmens,+T.&author=Keshavjee,+S.&author=Prasad,+V.&author=Makary,+M.+A.&author=Baral,+S.&author=H%C3%B8eg,+T.+B.&publication_year=2024&journal=Journal+of+Medical+Ethics&volume=50&pages=126%E2%80%9338&doi=10.1136/jme-2022-108449&pmid=36600579" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1136/jme-2022-108449" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36600579" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B34-preprints-107672" class="html-xx" data-content="34.">Stanworth, S. J.; New, H. V.; Apelseth, T. O.; Brunskill, S.; Cardigan, R.; Doree, C.; Germain, M.; Goldman, M.; Massey, E.; Prati, D.; Shehata, N.; So-Osman, C.; Thachil, J. , Effects of the COVID-19 pandemic on supply and use of blood for transfusion. <span class="html-italic">The Lancet Haematology</span> <b>2020</b>, <span class="html-italic">7</span>, e756–e64. [<a href="https://scholar.google.com/scholar_lookup?title=,+Effects+of+the+COVID-19+pandemic+on+supply+and+use+of+blood+for+transfusion&author=Stanworth,+S.+J.&author=New,+H.+V.&author=Apelseth,+T.+O.&author=Brunskill,+S.&author=Cardigan,+R.&author=Doree,+C.&author=Germain,+M.&author=Goldman,+M.&author=Massey,+E.&author=Prati,+D.&publication_year=2020&journal=The+Lancet+Haematology&volume=7&pages=e756%E2%80%93e64&doi=10.1016/S2352-3026(20)30186-1" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/S2352-3026(20)30186-1" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B35-preprints-107672" class="html-xx" data-content="35.">Chang, L.; Yan, Y.; Wang, L. , Coronavirus Disease 2019: Coronaviruses and Blood Safety. <span class="html-italic">Transfusion Medicine Reviews</span> <b>2020</b>, <span class="html-italic">34</span>, 75–80. [<a href="https://scholar.google.com/scholar_lookup?title=,+Coronavirus+Disease+2019:+Coronaviruses+and+Blood+Safety&author=Chang,+L.&author=Yan,+Y.&author=Wang,+L.&publication_year=2020&journal=Transfusion+Medicine+Reviews&volume=34&pages=75%E2%80%9380&doi=10.1016/j.tmrv.2020.02.003" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.tmrv.2020.02.003" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B36-preprints-107672" class="html-xx" data-content="36.">Bouhou, S.; Lahjouji, K.; Masrar, A. , Blood donor eligibility after COVID-19 vaccination: the current state of recommendations. <span class="html-italic">Pan Afr Med J</span> <b>2021</b>, <span class="html-italic">40</span>, 207. [<a href="https://scholar.google.com/scholar_lookup?title=,+Blood+donor+eligibility+after+COVID-19+vaccination:+the+current+state+of+recommendations&author=Bouhou,+S.&author=Lahjouji,+K.&author=Masrar,+A.&publication_year=2021&journal=Pan+Afr+Med+J&volume=40&pages=207&doi=10.11604/pamj.2021.40.207.29119&pmid=35136470" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.11604/pamj.2021.40.207.29119" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35136470" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B37-preprints-107672" class="html-xx" data-content="37.">Jacobs, J. W.; Bibb, L. A.; Savani, B. N.; Booth, G. S. , Refusing blood transfusions from COVID-19-vaccinated donors: are we repeating history? <span class="html-italic">British Journal of Haematology</span> <b>2021</b>, <span class="html-italic">196</span>, 585–88. [<a href="https://scholar.google.com/scholar_lookup?title=,+Refusing+blood+transfusions+from+COVID-19-vaccinated+donors:+are+we+repeating+history?&author=Jacobs,+J.+W.&author=Bibb,+L.+A.&author=Savani,+B.+N.&author=Booth,+G.+S.&publication_year=2021&journal=British+Journal+of+Haematology&volume=196&pages=585%E2%80%9388&doi=10.1111/bjh.17842&pmid=34523736" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/bjh.17842" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34523736" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B38-preprints-107672" class="html-xx" data-content="38.">Hunain, R.; Uday, U.; Rackimuthu, S.; Nawaz, F. A.; Narain, K.; Essar, M. Y.; Rehman, M. U.; Ahmad, S.; Butt, A. , Effects of SARS-CoV-2 vaccination on blood donation and blood banks in India. <span class="html-italic">Ann Med Surg (Lond)</span> <b>2022</b>, <span class="html-italic">78</span>, 103772. [<a href="https://scholar.google.com/scholar_lookup?title=,+Effects+of+SARS-CoV-2+vaccination+on+blood+donation+and+blood+banks+in+India&author=Hunain,+R.&author=Uday,+U.&author=Rackimuthu,+S.&author=Nawaz,+F.+A.&author=Narain,+K.&author=Essar,+M.+Y.&author=Rehman,+M.+U.&author=Ahmad,+S.&author=Butt,+A.&publication_year=2022&journal=Ann+Med+Surg+(Lond)&volume=78&pages=103772&doi=10.1016/j.amsu.2022.103772" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.amsu.2022.103772" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B39-preprints-107672" class="html-xx" data-content="39.">Roubinian, N. H.; Greene, J.; Liu, V. X.; Lee, C.; Mark, D. G.; Vinson, D. R.; Spencer, B. R.; Bruhn, R.; Bravo, M.; Stone, M.; Custer, B.; Kleinman, S.; Busch, M. P.; Norris, P. J. , Clinical outcomes in hospitalized plasma and platelet transfusion recipients prior to and following widespread blood donor SARS-CoV-2 infection and vaccination. <span class="html-italic">Transfusion</span> <b>2023</b>, <span class="html-italic">64</span>, 53–67. [<a href="https://scholar.google.com/scholar_lookup?title=,+Clinical+outcomes+in+hospitalized+plasma+and+platelet+transfusion+recipients+prior+to+and+following+widespread+blood+donor+SARS-CoV-2+infection+and+vaccination&author=Roubinian,+N.+H.&author=Greene,+J.&author=Liu,+V.+X.&author=Lee,+C.&author=Mark,+D.+G.&author=Vinson,+D.+R.&author=Spencer,+B.+R.&author=Bruhn,+R.&author=Bravo,+M.&author=Stone,+M.&publication_year=2023&journal=Transfusion&volume=64&pages=53%E2%80%9367&doi=10.1111/trf.17616" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/trf.17616" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B40-preprints-107672" class="html-xx" data-content="40.">Fertig, T. E.; Chitoiu, L.; Marta, D. S.; Ionescu, V.-S.; Cismasiu, V. B.; Radu, E.; Angheluta, G.; Dobre, M.; Serbanescu, A.; Hinescu, M. E.; Gherghiceanu, M. , Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination. <span class="html-italic">Biomedicines</span> <b>2022</b>, 10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Vaccine+mRNA+Can+Be+Detected+in+Blood+at+15+Days+Post-Vaccination&author=Fertig,+T.+E.&author=Chitoiu,+L.&author=Marta,+D.+S.&author=Ionescu,+V.-S.&author=Cismasiu,+V.+B.&author=Radu,+E.&author=Angheluta,+G.&author=Dobre,+M.&author=Serbanescu,+A.&author=Hinescu,+M.+E.&publication_year=2022&journal=Biomedicines&pages=10&doi=10.3390/biomedicines10071538" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/biomedicines10071538" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B41-preprints-107672" class="html-xx" data-content="41.">Mörz, M. , A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19. <span class="html-italic">Vaccines</span> <b>2022</b>, 10. [<a href="https://scholar.google.com/scholar_lookup?title=,+A+Case+Report:+Multifocal+Necrotizing+Encephalitis+and+Myocarditis+after+BNT162b2+mRNA+Vaccination+against+COVID-19&author=M%C3%B6rz,+M.&publication_year=2022&journal=Vaccines&pages=10&doi=10.3390/vaccines10101651&pmid=36298516" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/vaccines10101651" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36298516" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B42-preprints-107672" class="html-xx" data-content="42.">Yamamoto, M.; Kase, M.; Sano, H.; Kamijima, R.; Sano, S. , Persistent varicella zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion. <span class="html-italic">Journal of Cutaneous Immunology and Allergy</span> <b>2022</b>, <span class="html-italic">6</span>, 18–23. [<a href="https://scholar.google.com/scholar_lookup?title=,+Persistent+varicella+zoster+virus+infection+following+mRNA+COVID-19+vaccination+was+associated+with+the+presence+of+encoded+spike+protein+in+the+lesion&author=Yamamoto,+M.&author=Kase,+M.&author=Sano,+H.&author=Kamijima,+R.&author=Sano,+S.&publication_year=2022&journal=Journal+of+Cutaneous+Immunology+and+Allergy&volume=6&pages=18%E2%80%9323&doi=10.1002/cia2.12278" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1002/cia2.12278" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B43-preprints-107672" class="html-xx" data-content="43.">Castruita, J. A. S.; Schneider, U. V.; Mollerup, S.; Leineweber, T. D.; Weis, N.; Bukh, J.; Pedersen, M. S.; Westh, H. , SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination. <span class="html-italic">APMIS</span> <b>2023</b>, <span class="html-italic">131</span>, 128–32. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+mRNA+vaccine+sequences+circulate+in+blood+up+to+28+days+after+COVID-19+vaccination&author=Castruita,+J.+A.+S.&author=Schneider,+U.+V.&author=Mollerup,+S.&author=Leineweber,+T.+D.&author=Weis,+N.&author=Bukh,+J.&author=Pedersen,+M.+S.&author=Westh,+H.&publication_year=2023&journal=APMIS&volume=131&pages=128%E2%80%9332&doi=10.1111/apm.13294" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/apm.13294" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B44-preprints-107672" class="html-xx" data-content="44.">Krauson, A. J.; Casimero, F. V. C.; Siddiquee, Z.; Stone, J. R. , Duration of SARS-CoV-2 mRNA vaccine persistence and factors associated with cardiac involvement in recently vaccinated patients. <span class="html-italic">NPJ Vaccines</span> <b>2023</b>, <span class="html-italic">8</span>, 141. [<a href="https://scholar.google.com/scholar_lookup?title=,+Duration+of+SARS-CoV-2+mRNA+vaccine+persistence+and+factors+associated+with+cardiac+involvement+in+recently+vaccinated+patients&author=Krauson,+A.+J.&author=Casimero,+F.+V.+C.&author=Siddiquee,+Z.&author=Stone,+J.+R.&publication_year=2023&journal=NPJ+Vaccines&volume=8&pages=141&doi=10.1038/s41541-023-00742-7" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41541-023-00742-7" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B45-preprints-107672" class="html-xx" data-content="45.">Sano, S.; Yamamoto, M.; Kamijima, R.; Sano, H. , SARS-CoV-2 spike protein found in the acrosyringium and eccrine gland of repetitive miliaria-like lesions in a woman following mRNA vaccination. <span class="html-italic">J Dermatol</span> <b>2024</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+protein+found+in+the+acrosyringium+and+eccrine+gland+of+repetitive+miliaria-like+lesions+in+a+woman+following+mRNA+vaccination&author=Sano,+S.&author=Yamamoto,+M.&author=Kamijima,+R.&author=Sano,+H.&publication_year=2024&journal=J+Dermatol&doi=10.1111/1346-8138.17204" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/1346-8138.17204" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B46-preprints-107672" class="html-xx" data-content="46.">Xu, S.; Yang, K.; Li, R.; Zhang, L. , mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection. <span class="html-italic">Int J Mol Sci</span> <b>2020</b>, 21. [<a href="https://scholar.google.com/scholar_lookup?title=,+mRNA+Vaccine+Era-Mechanisms,+Drug+Platform+and+Clinical+Prospection&author=Xu,+S.&author=Yang,+K.&author=Li,+R.&author=Zhang,+L.&publication_year=2020&journal=Int+J+Mol+Sci&pages=21&doi=10.3390/ijms21186582&pmid=32916818" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/ijms21186582" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/32916818" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B47-preprints-107672" class="html-xx" data-content="47.">Bitounis, D.; Jacquinet, E.; Rogers, M. A.; Amiji, M. M. , Strategies to reduce the risks of mRNA drug and vaccine toxicity. <span class="html-italic">Nat Rev Drug Discov</span> <b>2024</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+Strategies+to+reduce+the+risks+of+mRNA+drug+and+vaccine+toxicity&author=Bitounis,+D.&author=Jacquinet,+E.&author=Rogers,+M.+A.&author=Amiji,+M.+M.&publication_year=2024&journal=Nat+Rev+Drug+Discov&doi=10.1038/s41573-023-00859-3&pmid=38263456" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41573-023-00859-3" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/38263456" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B48-preprints-107672" class="html-xx" data-content="48.">Yamamoto, K. , Adverse effects of COVID-19 vaccines and measures to prevent them. <span class="html-italic">Virology Journal</span> <b>2022</b>, 19. [<a href="https://scholar.google.com/scholar_lookup?title=,+Adverse+effects+of+COVID-19+vaccines+and+measures+to+prevent+them&author=Yamamoto,+K.&publication_year=2022&journal=Virology+Journal&pages=19&doi=10.1186/s12985-022-01831-0&pmid=35659687" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1186/s12985-022-01831-0" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35659687" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B49-preprints-107672" class="html-xx" data-content="49.">Rodriguez, Y.; Rojas, M.; Beltran, S.; Polo, F.; Camacho-Dominguez, L.; Morales, S. D.; Gershwin, M. E.; Anaya, J. M. , Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review. <span class="html-italic">J Autoimmun</span> <b>2022</b>, <span class="html-italic">132</span>, 102898. [<a href="https://scholar.google.com/scholar_lookup?title=,+Autoimmune+and+autoinflammatory+conditions+after+COVID-19+vaccination.+New+case+reports+and+updated+literature+review&author=Rodriguez,+Y.&author=Rojas,+M.&author=Beltran,+S.&author=Polo,+F.&author=Camacho-Dominguez,+L.&author=Morales,+S.+D.&author=Gershwin,+M.+E.&author=Anaya,+J.+M.&publication_year=2022&journal=J+Autoimmun&volume=132&pages=102898&doi=10.1016/j.jaut.2022.102898&pmid=36041291" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.jaut.2022.102898" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36041291" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B50-preprints-107672" class="html-xx" data-content="50.">Perico, L.; Morigi, M.; Galbusera, M.; Pezzotta, A.; Gastoldi, S.; Imberti, B.; Perna, A.; Ruggenenti, P.; Donadelli, R.; Benigni, A.; Remuzzi, G. , SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation. <span class="html-italic">Front Immunol</span> <b>2022</b>, <span class="html-italic">13</span>, 827146. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Spike+Protein+1+Activates+Microvascular+Endothelial+Cells+and+Complement+System+Leading+to+Platelet+Aggregation&author=Perico,+L.&author=Morigi,+M.&author=Galbusera,+M.&author=Pezzotta,+A.&author=Gastoldi,+S.&author=Imberti,+B.&author=Perna,+A.&author=Ruggenenti,+P.&author=Donadelli,+R.&author=Benigni,+A.&publication_year=2022&journal=Front+Immunol&volume=13&pages=827146&doi=10.3389/fimmu.2022.827146&pmid=35320941" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3389/fimmu.2022.827146" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35320941" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B51-preprints-107672" class="html-xx" data-content="51.">Idrees, D.; Kumar, V. , SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. <span class="html-italic">Biochemical and Biophysical Research Communications</span> <b>2021</b>, <span class="html-italic">554</span>, 94–98. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+protein+interactions+with+amyloidogenic+proteins:+Potential+clues+to+neurodegeneration&author=Idrees,+D.&author=Kumar,+V.&publication_year=2021&journal=Biochemical+and+Biophysical+Research+Communications&volume=554&pages=94%E2%80%9398&doi=10.1016/j.bbrc.2021.03.100&pmid=33789211" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.bbrc.2021.03.100" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33789211" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B52-preprints-107672" class="html-xx" data-content="52.">Charnley, M.; Islam, S.; Bindra, G. K.; Engwirda, J.; Ratcliffe, J.; Zhou, J.; Mezzenga, R.; Hulett, M. D.; Han, K.; Berryman, J. T.; Reynolds, N. P. , Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19. <span class="html-italic">Nature Communications</span> <b>2022</b>, 13. [<a href="https://scholar.google.com/scholar_lookup?title=,+Neurotoxic+amyloidogenic+peptides+in+the+proteome+of+SARS-COV2:+potential+implications+for+neurological+symptoms+in+COVID-19&author=Charnley,+M.&author=Islam,+S.&author=Bindra,+G.+K.&author=Engwirda,+J.&author=Ratcliffe,+J.&author=Zhou,+J.&author=Mezzenga,+R.&author=Hulett,+M.+D.&author=Han,+K.&author=Berryman,+J.+T.&publication_year=2022&journal=Nature+Communications&pages=13&doi=10.1038/s41467-022-30932-1" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41467-022-30932-1" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B53-preprints-107672" class="html-xx" data-content="53.">Kruger, A.; Vlok, M.; Turner, S.; Venter, C.; Laubscher, G. J.; Kell, D. B.; Pretorius, E. , Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system. <span class="html-italic">Cardiovascular Diabetology</span> <b>2022</b>, 21. [<a href="https://scholar.google.com/scholar_lookup?title=,+Proteomics+of+fibrin+amyloid+microclots+in+long+COVID/post-acute+sequelae+of+COVID-19+(PASC)+shows+many+entrapped+pro-inflammatory+molecules+that+may+also+contribute+to+a+failed+fibrinolytic+system&author=Kruger,+A.&author=Vlok,+M.&author=Turner,+S.&author=Venter,+C.&author=Laubscher,+G.+J.&author=Kell,+D.+B.&author=Pretorius,+E.&publication_year=2022&journal=Cardiovascular+Diabetology&pages=21&doi=10.1186/s12933-022-01623-4&pmid=36131342" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1186/s12933-022-01623-4" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36131342" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B54-preprints-107672" class="html-xx" data-content="54.">Nyström, S.; Hammarström, P. , Amyloidogenesis of SARS-CoV-2 Spike Protein. <span class="html-italic">Journal of the American Chemical Society</span> <b>2022</b>, <span class="html-italic">144</span>, 8945–50. [<a href="https://scholar.google.com/scholar_lookup?title=,+Amyloidogenesis+of+SARS-CoV-2+Spike+Protein&author=Nystr%C3%B6m,+S.&author=Hammarstr%C3%B6m,+P.&publication_year=2022&journal=Journal+of+the+American+Chemical+Society&volume=144&pages=8945%E2%80%9350&doi=10.1021/jacs.2c03925" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1021/jacs.2c03925" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B55-preprints-107672" class="html-xx" data-content="55.">Chesney, A. D.; Maiti, B.; Hansmann, U. H. E. , SARS-COV-2 spike protein fragment eases amyloidogenesis of alpha-synuclein. <span class="html-italic">J Chem Phys</span> <b>2023</b>, 159. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-COV-2+spike+protein+fragment+eases+amyloidogenesis+of+alpha-synuclein&author=Chesney,+A.+D.&author=Maiti,+B.&author=Hansmann,+U.+H.+E.&publication_year=2023&journal=J+Chem+Phys&pages=159" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>]</li> <li id="B56-preprints-107672" class="html-xx" data-content="56.">Olajide, O. A.; Iwuanyanwu, V. U.; Adegbola, O. D.; Al-Hindawi, A. A. , SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia. <span class="html-italic">Molecular Neurobiology</span> <b>2021</b>, <span class="html-italic">59</span>, 445–58. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Spike+Glycoprotein+S1+Induces+Neuroinflammation+in+BV-2+Microglia&author=Olajide,+O.+A.&author=Iwuanyanwu,+V.+U.&author=Adegbola,+O.+D.&author=Al-Hindawi,+A.+A.&publication_year=2021&journal=Molecular+Neurobiology&volume=59&pages=445%E2%80%9358&doi=10.1007/s12035-021-02593-6" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1007/s12035-021-02593-6" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B57-preprints-107672" class="html-xx" data-content="57.">Oh, J.; Cho, W.-H.; Barcelon, E.; Kim, K. H.; Hong, J.; Lee, S. J. , SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. <span class="html-italic">Scientific Reports</span> <b>2022</b>, 12. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+protein+induces+cognitive+deficit+and+anxiety-like+behavior+in+mouse+via+non-cell+autonomous+hippocampal+neuronal+death&author=Oh,+J.&author=Cho,+W.-H.&author=Barcelon,+E.&author=Kim,+K.+H.&author=Hong,+J.&author=Lee,+S.+J.&publication_year=2022&journal=Scientific+Reports&pages=12&doi=10.1038/s41598-022-09410-7&pmid=35361832" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41598-022-09410-7" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35361832" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B58-preprints-107672" class="html-xx" data-content="58.">O'Brien, B. C. V.; Weber, L.; Hueffer, K.; Weltzin, M. M. , SARS-CoV-2 spike ectodomain targets alpha7 nicotinic acetylcholine receptors. <span class="html-italic">J Biol Chem</span> <b>2023</b>, <span class="html-italic">299</span>, 104707. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+ectodomain+targets+alpha7+nicotinic+acetylcholine+receptors&author=O'Brien,+B.+C.+V.&author=Weber,+L.&author=Hueffer,+K.&author=Weltzin,+M.+M.&publication_year=2023&journal=J+Biol+Chem&volume=299&pages=104707" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>]</li> <li id="B59-preprints-107672" class="html-xx" data-content="59.">Buzhdygan, T. P.; DeOre, B. J.; Baldwin-Leclair, A.; Bullock, T. A.; McGary, H. M.; Khan, J. A.; Razmpour, R.; Hale, J. F.; Galie, P. A.; Potula, R.; Andrews, A. M.; Ramirez, S. H. , The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier. <span class="html-italic">Neurobiol Dis</span> <b>2020</b>, <span class="html-italic">146</span>, 105131. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+SARS-CoV-2+spike+protein+alters+barrier+function+in+2D+static+and+3D+microfluidic+in-vitro+models+of+the+human+blood-brain+barrier&author=Buzhdygan,+T.+P.&author=DeOre,+B.+J.&author=Baldwin-Leclair,+A.&author=Bullock,+T.+A.&author=McGary,+H.+M.&author=Khan,+J.+A.&author=Razmpour,+R.&author=Hale,+J.+F.&author=Galie,+P.+A.&author=Potula,+R.&publication_year=2020&journal=Neurobiol+Dis&volume=146&pages=105131&doi=10.1016/j.nbd.2020.105131" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.nbd.2020.105131" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B60-preprints-107672" class="html-xx" data-content="60.">Rhea, E. M.; Logsdon, A. F.; Hansen, K. M.; Williams, L. M.; Reed, M. J.; Baumann, K. K.; Holden, S. J.; Raber, J.; Banks, W. A.; Erickson, M. A. , The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice. <span class="html-italic">Nature Neuroscience</span> <b>2020</b>, <span class="html-italic">24</span>, 368–78. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+S1+protein+of+SARS-CoV-2+crosses+the+blood%E2%80%93brain+barrier+in+mice&author=Rhea,+E.+M.&author=Logsdon,+A.+F.&author=Hansen,+K.+M.&author=Williams,+L.+M.&author=Reed,+M.+J.&author=Baumann,+K.+K.&author=Holden,+S.+J.&author=Raber,+J.&author=Banks,+W.+A.&author=Erickson,+M.+A.&publication_year=2020&journal=Nature+Neuroscience&volume=24&pages=368%E2%80%9378&doi=10.1038/s41593-020-00771-8" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41593-020-00771-8" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B61-preprints-107672" class="html-xx" data-content="61.">Zhang, L.; Zhou, L.; Bao, L.; Liu, J.; Zhu, H.; Lv, Q.; Liu, R.; Chen, W.; Tong, W.; Wei, Q.; Xu, Y.; Deng, W.; Gao, H.; Xue, J.; Song, Z.; Yu, P.; Han, Y.; Zhang, Y.; Sun, X.; Yu, X.; Qin, C. , SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration. <span class="html-italic">Signal Transduction and Targeted Therapy</span> <b>2021</b>, 6. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+crosses+the+blood%E2%80%93brain+barrier+accompanied+with+basement+membrane+disruption+without+tight+junctions+alteration&author=Zhang,+L.&author=Zhou,+L.&author=Bao,+L.&author=Liu,+J.&author=Zhu,+H.&author=Lv,+Q.&author=Liu,+R.&author=Chen,+W.&author=Tong,+W.&author=Wei,+Q.&publication_year=2021&journal=Signal+Transduction+and+Targeted+Therapy&pages=6&doi=10.1038/s41392-021-00719-9" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41392-021-00719-9" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B62-preprints-107672" class="html-xx" data-content="62.">Trougakos, I. P.; Terpos, E.; Alexopoulos, H.; Politou, M.; Paraskevis, D.; Scorilas, A.; Kastritis, E.; Andreakos, E.; Dimopoulos, M. A. , Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis. <span class="html-italic">Trends in Molecular Medicine</span> <b>2022</b>, <span class="html-italic">28</span>, 542–54. [<a href="https://scholar.google.com/scholar_lookup?title=,+Adverse+effects+of+COVID-19+mRNA+vaccines:+the+spike+hypothesis&author=Trougakos,+I.+P.&author=Terpos,+E.&author=Alexopoulos,+H.&author=Politou,+M.&author=Paraskevis,+D.&author=Scorilas,+A.&author=Kastritis,+E.&author=Andreakos,+E.&author=Dimopoulos,+M.+A.&publication_year=2022&journal=Trends+in+Molecular+Medicine&volume=28&pages=542%E2%80%9354&doi=10.1016/j.molmed.2022.04.007&pmid=35537987" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.molmed.2022.04.007" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35537987" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B63-preprints-107672" class="html-xx" data-content="63.">Halma, M. T. J.; Plothe, C.; Marik, P.; Lawrie, T. A. , Strategies for the Management of Spike Protein-Related Pathology. <span class="html-italic">Microorganisms</span> <b>2023</b>, 11. [<a href="https://scholar.google.com/scholar_lookup?title=,+Strategies+for+the+Management+of+Spike+Protein-Related+Pathology&author=Halma,+M.+T.+J.&author=Plothe,+C.&author=Marik,+P.&author=Lawrie,+T.+A.&publication_year=2023&journal=Microorganisms&pages=11&doi=10.3390/microorganisms11051308&pmid=37317282" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/microorganisms11051308" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/37317282" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B64-preprints-107672" class="html-xx" data-content="64.">Monge, S.; Pastor-Barriuso, R.; Hernán, M. A. , The imprinting effect of covid-19 vaccines: an expected selection bias in observational studies. <span class="html-italic">Bmj</span> <b>2023</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+imprinting+effect+of+covid-19+vaccines:+an+expected+selection+bias+in+observational+studies&author=Monge,+S.&author=Pastor-Barriuso,+R.&author=Hern%C3%A1n,+M.+A.&publication_year=2023&journal=Bmj&doi=10.1136/bmj-2022-074404" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1136/bmj-2022-074404" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B65-preprints-107672" class="html-xx" data-content="65.">Wang, Q.; Guo, Y.; Tam, A. R.; Valdez, R.; Gordon, A.; Liu, L.; Ho, D. D. , Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine. <span class="html-italic">Cell Rep Med</span> <b>2023</b>, <span class="html-italic">4</span>, 101258. [<a href="https://scholar.google.com/scholar_lookup?title=,+Deep+immunological+imprinting+due+to+the+ancestral+spike+in+the+current+bivalent+COVID-19+vaccine&author=Wang,+Q.&author=Guo,+Y.&author=Tam,+A.+R.&author=Valdez,+R.&author=Gordon,+A.&author=Liu,+L.&author=Ho,+D.+D.&publication_year=2023&journal=Cell+Rep+Med&volume=4&pages=101258&doi=10.1016/j.xcrm.2023.101258" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.xcrm.2023.101258" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B66-preprints-107672" class="html-xx" data-content="66.">Tortorici, M. A.; Addetia, A.; Seo, A. J.; Brown, J.; Sprouse, K.; Logue, J.; Clark, E.; Franko, N.; Chu, H.; Veesler, D. , Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans. <span class="html-italic">Immunity 2024, 57, (4), 904-11 e4</span>.</li> <li id="B67-preprints-107672" class="html-xx" data-content="67.">Pusnik, J.; Zorn, J.; Monzon-Posadas, W. O.; Peters, K.; Osypchuk, E.; Blaschke, S.; Streeck, H. , Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin. <span class="html-italic">Nat Commun</span> <b>2024</b>, <span class="html-italic">15</span>, 3102. [<a href="https://scholar.google.com/scholar_lookup?title=,+Vaccination+impairs+de+novo+immune+response+to+omicron+breakthrough+infection,+a+precondition+for+the+original+antigenic+sin&author=Pusnik,+J.&author=Zorn,+J.&author=Monzon-Posadas,+W.+O.&author=Peters,+K.&author=Osypchuk,+E.&author=Blaschke,+S.&author=Streeck,+H.&publication_year=2024&journal=Nat+Commun&volume=15&pages=3102&doi=10.1038/s41467-024-47451-w" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41467-024-47451-w" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B68-preprints-107672" class="html-xx" data-content="68.">Shrestha, N. K.; Burke, P. C.; Nowacki, A. S.; Simon, J. F.; Hagen, A.; Gordon, S. M. , Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine. <span class="html-italic">Open Forum Infectious Diseases</span> <b>2023</b>, 10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Effectiveness+of+the+Coronavirus+Disease+2019+Bivalent+Vaccine&author=Shrestha,+N.+K.&author=Burke,+P.+C.&author=Nowacki,+A.+S.&author=Simon,+J.+F.&author=Hagen,+A.&author=Gordon,+S.+M.&publication_year=2023&journal=Open+Forum+Infectious+Diseases&pages=10&doi=10.1093/ofid/ofad209" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1093/ofid/ofad209" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B69-preprints-107672" class="html-xx" data-content="69.">Arvin, A. M.; Fink, K.; Schmid, M. A.; Cathcart, A.; Spreafico, R.; Havenar-Daughton, C.; Lanzavecchia, A.; Corti, D.; Virgin, H. W. , A perspective on potential antibody-dependent enhancement of SARS-CoV-2. <span class="html-italic">Nature</span> <b>2020</b>, <span class="html-italic">584</span>, 353–63. [<a href="https://scholar.google.com/scholar_lookup?title=,+A+perspective+on+potential+antibody-dependent+enhancement+of+SARS-CoV-2&author=Arvin,+A.+M.&author=Fink,+K.&author=Schmid,+M.+A.&author=Cathcart,+A.&author=Spreafico,+R.&author=Havenar-Daughton,+C.&author=Lanzavecchia,+A.&author=Corti,+D.&author=Virgin,+H.+W.&publication_year=2020&journal=Nature&volume=584&pages=353%E2%80%9363&doi=10.1038/s41586-020-2538-8" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41586-020-2538-8" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B70-preprints-107672" class="html-xx" data-content="70.">Lee, W. S.; Wheatley, A. K.; Kent, S. J.; DeKosky, B. J. , Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies. <span class="html-italic">Nat Microbiol</span> <b>2020</b>, <span class="html-italic">5</span>, 1185–91. [<a href="https://scholar.google.com/scholar_lookup?title=,+Antibody-dependent+enhancement+and+SARS-CoV-2+vaccines+and+therapies&author=Lee,+W.+S.&author=Wheatley,+A.+K.&author=Kent,+S.+J.&author=DeKosky,+B.+J.&publication_year=2020&journal=Nat+Microbiol&volume=5&pages=1185%E2%80%9391&doi=10.1038/s41564-020-00789-5" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41564-020-00789-5" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B71-preprints-107672" class="html-xx" data-content="71.">Irrgang, P.; Gerling, J.; Kocher, K.; Lapuente, D.; Steininger, P.; Habenicht, K.; Wytopil, M.; Beileke, S.; Schäfer, S.; Zhong, J.; Ssebyatika, G.; Krey, T.; Falcone, V.; Schülein, C.; Peter, A. S.; Nganou-Makamdop, K.; Hengel, H.; Held, J.; Bogdan, C.; Überla, K.; Schober, K.; Winkler, T. H.; Tenbusch, M. , Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. <span class="html-italic">Science Immunology</span> <b>2023</b>, 8. [<a href="https://scholar.google.com/scholar_lookup?title=,+Class+switch+toward+noninflammatory,+spike-specific+IgG4+antibodies+after+repeated+SARS-CoV-2+mRNA+vaccination&author=Irrgang,+P.&author=Gerling,+J.&author=Kocher,+K.&author=Lapuente,+D.&author=Steininger,+P.&author=Habenicht,+K.&author=Wytopil,+M.&author=Beileke,+S.&author=Sch%C3%A4fer,+S.&author=Zhong,+J.&publication_year=2023&journal=Science+Immunology&pages=8&doi=10.1126/sciimmunol.ade2798" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1126/sciimmunol.ade2798" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B72-preprints-107672" class="html-xx" data-content="72.">Kiszel, P.; Sík, P.; Miklós, J.; Kajdácsi, E.; Sinkovits, G.; Cervenak, L.; Prohászka, Z. , Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. <span class="html-italic">Scientific Reports</span> <b>2023</b>, 13. [<a href="https://scholar.google.com/scholar_lookup?title=,+Class+switch+towards+spike+protein-specific+IgG4+antibodies+after+SARS-CoV-2+mRNA+vaccination+depends+on+prior+infection+history&author=Kiszel,+P.&author=S%C3%ADk,+P.&author=Mikl%C3%B3s,+J.&author=Kajd%C3%A1csi,+E.&author=Sinkovits,+G.&author=Cervenak,+L.&author=Proh%C3%A1szka,+Z.&publication_year=2023&journal=Scientific+Reports&pages=13&doi=10.1038/s41598-023-40103-x" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41598-023-40103-x" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B73-preprints-107672" class="html-xx" data-content="73.">Uversky, V.; Redwan, E.; Makis, W.; Rubio-Casillas, A. , IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. <span class="html-italic">Vaccines</span> <b>2023</b>, 11. [<a href="https://scholar.google.com/scholar_lookup?title=,+IgG4+Antibodies+Induced+by+Repeated+Vaccination+May+Generate+Immune+Tolerance+to+the+SARS-CoV-2+Spike+Protein&author=Uversky,+V.&author=Redwan,+E.&author=Makis,+W.&author=Rubio-Casillas,+A.&publication_year=2023&journal=Vaccines&pages=11&doi=10.3390/vaccines11050991" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/vaccines11050991" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B74-preprints-107672" class="html-xx" data-content="74.">Yoshimura, M.; Sakamoto, A.; Ozuru, R.; Kurihara, Y.; Itoh, R.; Ishii, K.; Shimizu, A.; Chou, B.; Nabeshima, S.; Hiromatsu, K. , The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines. <span class="html-italic">Int J Infect Dis</span> <b>2024</b>, <span class="html-italic">139</span>, 1–5. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+appearance+of+anti-spike+receptor+binding+domain+immunoglobulin+G4+responses+after+repetitive+immunization+with+messenger+RNA-based+COVID-19+vaccines&author=Yoshimura,+M.&author=Sakamoto,+A.&author=Ozuru,+R.&author=Kurihara,+Y.&author=Itoh,+R.&author=Ishii,+K.&author=Shimizu,+A.&author=Chou,+B.&author=Nabeshima,+S.&author=Hiromatsu,+K.&publication_year=2024&journal=Int+J+Infect+Dis&volume=139&pages=1%E2%80%935&doi=10.1016/j.ijid.2023.11.028" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ijid.2023.11.028" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B75-preprints-107672" class="html-xx" data-content="75.">Espino, A. M.; Armina-Rodriguez, A.; Alvarez, L.; Ocasio-Malave, C.; Ramos-Nieves, R.; Rodriguez Martino, E. I.; Lopez-Marte, P.; Torres, E. A.; Sariol, C. A. , The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine. <span class="html-italic">Viruses</span> <b>2024</b>, 16. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+Anti-SARS-CoV-2+IgG1+and+IgG3+Antibody+Isotypes+with+Limited+Neutralizing+Capacity+against+Omicron+Elicited+in+a+Latin+Population+a+Switch+toward+IgG4+after+Multiple+Doses+with+the+mRNA+Pfizer-BioNTech+Vaccine&author=Espino,+A.+M.&author=Armina-Rodriguez,+A.&author=Alvarez,+L.&author=Ocasio-Malave,+C.&author=Ramos-Nieves,+R.&author=Rodriguez+Martino,+E.+I.&author=Lopez-Marte,+P.&author=Torres,+E.+A.&author=Sariol,+C.+A.&publication_year=2024&journal=Viruses&pages=16&doi=10.3390/v16020187" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/v16020187" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B76-preprints-107672" class="html-xx" data-content="76.">Rubio-Casillas, A.; Cowley, D.; Raszek, M.; Uversky, V. N.; Redwan, E. M. , Review: N1-methyl-pseudouridine (m1Psi): Friend or foe of cancer? <span class="html-italic">Int J Biol Macromol</span> <b>2024</b>, <span class="html-italic">(Pt 1)</span> <span class="html-italic">Pt 1</span>, 131427. [<a href="https://scholar.google.com/scholar_lookup?title=,+Review:+N1-methyl-pseudouridine+(m1Psi):+Friend+or+foe+of+cancer?&author=Rubio-Casillas,+A.&author=Cowley,+D.&author=Raszek,+M.&author=Uversky,+V.+N.&author=Redwan,+E.+M.&publication_year=2024&journal=Int+J+Biol+Macromol&volume=(Pt+1)&issue=Pt+1&pages=131427&doi=10.1016/j.ijbiomac.2024.131427" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ijbiomac.2024.131427" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B77-preprints-107672" class="html-xx" data-content="77.">Murata, K.; Nakao, N.; Ishiuchi, N.; Fukui, T.; Katsuya, N.; Fukumoto, W.; Oka, H.; Yoshikawa, N.; Nagao, T.; Namera, A.; Kakimoto, N.; Oue, N.; Awai, K.; Yoshimoto, K.; Nagao, M. , Four cases of cytokine storm after COVID-19 vaccination: Case report. <span class="html-italic">Front Immunol</span> <b>2022</b>, <span class="html-italic">13</span>, 967226. [<a href="https://scholar.google.com/scholar_lookup?title=,+Four+cases+of+cytokine+storm+after+COVID-19+vaccination:+Case+report&author=Murata,+K.&author=Nakao,+N.&author=Ishiuchi,+N.&author=Fukui,+T.&author=Katsuya,+N.&author=Fukumoto,+W.&author=Oka,+H.&author=Yoshikawa,+N.&author=Nagao,+T.&author=Namera,+A.&publication_year=2022&journal=Front+Immunol&volume=13&pages=967226&doi=10.3389/fimmu.2022.967226" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3389/fimmu.2022.967226" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B78-preprints-107672" class="html-xx" data-content="78.">Masset, C.; Kervella, D.; Kandel-Aznar, C.; Fantou, A.; Blancho, G.; Hamidou, M. , Relapse of IgG4-related nephritis following mRNA COVID-19 vaccine. <span class="html-italic">Kidney International</span> <b>2021</b>, <span class="html-italic">100</span>, 465–66. [<a href="https://scholar.google.com/scholar_lookup?title=,+Relapse+of+IgG4-related+nephritis+following+mRNA+COVID-19+vaccine&author=Masset,+C.&author=Kervella,+D.&author=Kandel-Aznar,+C.&author=Fantou,+A.&author=Blancho,+G.&author=Hamidou,+M.&publication_year=2021&journal=Kidney+International&volume=100&pages=465%E2%80%9366&doi=10.1016/j.kint.2021.06.002" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.kint.2021.06.002" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B79-preprints-107672" class="html-xx" data-content="79.">Patel, A. H. , Acute Liver Injury and IgG4-related Autoimmune Pancreatitis following mRNA based COVID-19 vaccination. <span class="html-italic">Hepatology Forum</span> <b>2022</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+Acute+Liver+Injury+and+IgG4-related+Autoimmune+Pancreatitis+following+mRNA+based+COVID-19+vaccination&author=Patel,+A.+H.&publication_year=2022&journal=Hepatology+Forum&doi=10.14744/hf.2022.2022.0019" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.14744/hf.2022.2022.0019" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B80-preprints-107672" class="html-xx" data-content="80.">Aochi, S.; Uehara, M.; Yamamoto, M. , IgG4-related Disease Emerging after COVID-19 mRNA Vaccination. <span class="html-italic">Internal Medicine</span> <b>2023</b>, <span class="html-italic">62</span>, 1547–51. [<a href="https://scholar.google.com/scholar_lookup?title=,+IgG4-related+Disease+Emerging+after+COVID-19+mRNA+Vaccination&author=Aochi,+S.&author=Uehara,+M.&author=Yamamoto,+M.&publication_year=2023&journal=Internal+Medicine&volume=62&pages=1547%E2%80%9351&doi=10.2169/internalmedicine.1125-22" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.2169/internalmedicine.1125-22" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B81-preprints-107672" class="html-xx" data-content="81.">Katsikas Triantafyllidis, K.; Giannos, P.; Mian, I. T.; Kyrtsonis, G.; Kechagias, K. S. , Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports. <span class="html-italic">Vaccines</span> <b>2021</b>, 9. [<a href="https://scholar.google.com/scholar_lookup?title=,+Varicella+Zoster+Virus+Reactivation+Following+COVID-19+Vaccination:+A+Systematic+Review+of+Case+Reports&author=Katsikas+Triantafyllidis,+K.&author=Giannos,+P.&author=Mian,+I.+T.&author=Kyrtsonis,+G.&author=Kechagias,+K.+S.&publication_year=2021&journal=Vaccines&pages=9&doi=10.3390/vaccines9091013" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/vaccines9091013" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B82-preprints-107672" class="html-xx" data-content="82.">Lensen, R.; Netea, M. G.; Rosendaal, F. R. , Hepatitis C Virus Reactivation Following COVID-19 Vaccination - A Case Report. <span class="html-italic">Int Med Case Rep J</span> <b>2021</b>, <span class="html-italic">14</span>, 573–76. [<a href="https://scholar.google.com/scholar_lookup?title=,+Hepatitis+C+Virus+Reactivation+Following+COVID-19+Vaccination+-+A+Case+Report&author=Lensen,+R.&author=Netea,+M.+G.&author=Rosendaal,+F.+R.&publication_year=2021&journal=Int+Med+Case+Rep+J&volume=14&pages=573%E2%80%9376" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>]</li> <li id="B83-preprints-107672" class="html-xx" data-content="83.">Psichogiou, M.; Samarkos, M.; Mikos, N.; Hatzakis, A. , Reactivation of Varicella Zoster Virus after Vaccination for SARS-CoV-2. <span class="html-italic">Vaccines</span> <b>2021</b>, 9. [<a href="https://scholar.google.com/scholar_lookup?title=,+Reactivation+of+Varicella+Zoster+Virus+after+Vaccination+for+SARS-CoV-2&author=Psichogiou,+M.&author=Samarkos,+M.&author=Mikos,+N.&author=Hatzakis,+A.&publication_year=2021&journal=Vaccines&pages=9&doi=10.3390/vaccines9060572" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/vaccines9060572" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B84-preprints-107672" class="html-xx" data-content="84.">Fathy, R. A.; McMahon, D. E.; Lee, C.; Chamberlin, G. C.; Rosenbach, M.; Lipoff, J. B.; Tyagi, A.; Desai, S. R.; French, L. E.; Lim, H. W.; Thiers, B. H.; Hruza, G. J.; Fassett, M.; Fox, L. P.; Greenberg, H. L.; Blumenthal, K.; Freeman, E. E. , Varicella-zoster and herpes simplex virus reactivation post-COVID-19 vaccination: a review of 40 cases in an International Dermatology Registry. <span class="html-italic">J Eur Acad Dermatol Venereol</span> <b>2022</b>, <span class="html-italic">36</span>, e6–e9. [<a href="https://scholar.google.com/scholar_lookup?title=,+Varicella-zoster+and+herpes+simplex+virus+reactivation+post-COVID-19+vaccination:+a+review+of+40+cases+in+an+International+Dermatology+Registry&author=Fathy,+R.+A.&author=McMahon,+D.+E.&author=Lee,+C.&author=Chamberlin,+G.+C.&author=Rosenbach,+M.&author=Lipoff,+J.+B.&author=Tyagi,+A.&author=Desai,+S.+R.&author=French,+L.+E.&author=Lim,+H.+W.&publication_year=2022&journal=J+Eur+Acad+Dermatol+Venereol&volume=36&pages=e6%E2%80%93e9&doi=10.1111/jdv.17646" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/jdv.17646" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B85-preprints-107672" class="html-xx" data-content="85.">Gringeri, M.; Battini, V.; Cammarata, G.; Mosini, G.; Guarnieri, G.; Leoni, C.; Pozzi, M.; Radice, S.; Clementi, E.; Carnovale, C. , Herpes zoster and simplex reactivation following COVID-19 vaccination: new insights from a vaccine adverse event reporting system (VAERS) database analysis. <span class="html-italic">Expert Rev Vaccines</span> <b>2022</b>, <span class="html-italic">21</span>, 675–84. [<a href="https://scholar.google.com/scholar_lookup?title=,+Herpes+zoster+and+simplex+reactivation+following+COVID-19+vaccination:+new+insights+from+a+vaccine+adverse+event+reporting+system+(VAERS)+database+analysis&author=Gringeri,+M.&author=Battini,+V.&author=Cammarata,+G.&author=Mosini,+G.&author=Guarnieri,+G.&author=Leoni,+C.&author=Pozzi,+M.&author=Radice,+S.&author=Clementi,+E.&author=Carnovale,+C.&publication_year=2022&journal=Expert+Rev+Vaccines&volume=21&pages=675%E2%80%9384&doi=10.1080/14760584.2022.2044799" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1080/14760584.2022.2044799" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B86-preprints-107672" class="html-xx" data-content="86.">Hertel, M.; Heiland, M.; Nahles, S.; von Laffert, M.; Mura, C.; Bourne, P. E.; Preissner, R.; Preissner, S. , Real-world evidence from over one million COVID-19 vaccinations is consistent with reactivation of the varicella-zoster virus. <span class="html-italic">Journal of the European Academy of Dermatology and Venereology</span> <b>2022</b>, <span class="html-italic">36</span>, 1342–48. [<a href="https://scholar.google.com/scholar_lookup?title=,+Real-world+evidence+from+over+one+million+COVID-19+vaccinations+is+consistent+with+reactivation+of+the+varicella-zoster+virus&author=Hertel,+M.&author=Heiland,+M.&author=Nahles,+S.&author=von+Laffert,+M.&author=Mura,+C.&author=Bourne,+P.+E.&author=Preissner,+R.&author=Preissner,+S.&publication_year=2022&journal=Journal+of+the+European+Academy+of+Dermatology+and+Venereology&volume=36&pages=1342%E2%80%9348&doi=10.1111/jdv.18184" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/jdv.18184" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B87-preprints-107672" class="html-xx" data-content="87.">Shafiee, A.; Amini, M. J.; Arabzadeh Bahri, R.; Jafarabady, K.; Salehi, S. A.; Hajishah, H.; Mozhgani, S.-H. , Herpesviruses reactivation following COVID-19 vaccination: a systematic review and meta-analysis. <span class="html-italic">European Journal of Medical Research</span> <b>2023</b>, 28. [<a href="https://scholar.google.com/scholar_lookup?title=,+Herpesviruses+reactivation+following+COVID-19+vaccination:+a+systematic+review+and+meta-analysis&author=Shafiee,+A.&author=Amini,+M.+J.&author=Arabzadeh+Bahri,+R.&author=Jafarabady,+K.&author=Salehi,+S.+A.&author=Hajishah,+H.&author=Mozhgani,+S.-H.&publication_year=2023&journal=European+Journal+of+Medical+Research&pages=28&doi=10.1186/s40001-023-01238-9" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1186/s40001-023-01238-9" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B88-preprints-107672" class="html-xx" data-content="88.">Culver, J. , Preventing transmission of blood-borne pathogens: a compelling argument for effective device-selection strategies. <span class="html-italic">Am J Infect Control</span> <b>1997</b>, <span class="html-italic">25</span>, 430–3. [<a href="https://scholar.google.com/scholar_lookup?title=,+Preventing+transmission+of+blood-borne+pathogens:+a+compelling+argument+for+effective+device-selection+strategies&author=Culver,+J.&publication_year=1997&journal=Am+J+Infect+Control&volume=25&pages=430%E2%80%933&doi=10.1016/S0196-6553(97)90094-8&pmid=9343630" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/S0196-6553(97)90094-8" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9343630" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B89-preprints-107672" class="html-xx" data-content="89.">Beltrami, E. M.; Williams, I. T.; Shapiro, C. N.; Chamberland, M. E. , Risk and Management of Blood-Borne Infections in Health Care Workers. <span class="html-italic">Clinical Microbiology Reviews</span> <b>2000</b>, <span class="html-italic">13</span>, 385–407. [<a href="https://scholar.google.com/scholar_lookup?title=,+Risk+and+Management+of+Blood-Borne+Infections+in+Health+Care+Workers&author=Beltrami,+E.+M.&author=Williams,+I.+T.&author=Shapiro,+C.+N.&author=Chamberland,+M.+E.&publication_year=2000&journal=Clinical+Microbiology+Reviews&volume=13&pages=385%E2%80%93407&doi=10.1128/CMR.13.3.385" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1128/CMR.13.3.385" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B90-preprints-107672" class="html-xx" data-content="90.">Ison, M. G.; Grossi, P.; Practice, A. S. T. I. D. C. o. , Donor-derived infections in solid organ transplantation. <span class="html-italic">Am J Transplant</span> <b>2013</b>, <span class="html-italic">13 Suppl 4</span>, 22–30. [<a href="https://scholar.google.com/scholar_lookup?title=,+Donor-derived+infections+in+solid+organ+transplantation&author=Ison,+M.+G.&author=Grossi,+P.&author=Practice,+A.+S.+T.+I.+D.+C.+o.&publication_year=2013&journal=Am+J+Transplant&volume=13+Suppl+4&pages=22%E2%80%9330&doi=10.1111/ajt.12095" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/ajt.12095" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B91-preprints-107672" class="html-xx" data-content="91.">Fishman, J. A.; Grossi, P. A. , Donor-derived infection--the challenge for transplant safety. <span class="html-italic">Nat Rev Nephrol</span> <b>2014</b>, <span class="html-italic">10</span>, 663–72. [<a href="https://scholar.google.com/scholar_lookup?title=,+Donor-derived+infection--the+challenge+for+transplant+safety&author=Fishman,+J.+A.&author=Grossi,+P.+A.&publication_year=2014&journal=Nat+Rev+Nephrol&volume=10&pages=663%E2%80%9372&doi=10.1038/nrneph.2014.159" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/nrneph.2014.159" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B92-preprints-107672" class="html-xx" data-content="92.">Bahakel, H. K.; Pellet Madan, R.; Danziger-Isakov, L. , Approach to suspected donor-derived infections. <span class="html-italic">Front Pediatr</span> <b>2023</b>, <span class="html-italic">11</span>, 1265023. [<a href="https://scholar.google.com/scholar_lookup?title=,+Approach+to+suspected+donor-derived+infections&author=Bahakel,+H.+K.&author=Pellet+Madan,+R.&author=Danziger-Isakov,+L.&publication_year=2023&journal=Front+Pediatr&volume=11&pages=1265023&doi=10.3389/fped.2023.1265023" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3389/fped.2023.1265023" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B93-preprints-107672" class="html-xx" data-content="93.">Tobin, G. J.; Trujillo, J. D.; Bushnell, R. V.; Lin, G.; Chaudhuri, A. R.; Long, J.; Barrera, J.; Pena, L.; Grubman, M. J.; Nara, P. L. , Deceptive imprinting and immune refocusing in vaccine design. <span class="html-italic">Vaccine</span> <b>2008</b>, <span class="html-italic">26</span>, 6189–99. [<a href="https://scholar.google.com/scholar_lookup?title=,+Deceptive+imprinting+and+immune+refocusing+in+vaccine+design&author=Tobin,+G.+J.&author=Trujillo,+J.+D.&author=Bushnell,+R.+V.&author=Lin,+G.&author=Chaudhuri,+A.+R.&author=Long,+J.&author=Barrera,+J.&author=Pena,+L.&author=Grubman,+M.+J.&author=Nara,+P.+L.&publication_year=2008&journal=Vaccine&volume=26&pages=6189%E2%80%9399&doi=10.1016/j.vaccine.2008.09.080" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.vaccine.2008.09.080" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B94-preprints-107672" class="html-xx" data-content="94.">Gatto, D.; Brink, R. , The germinal center reaction. <span class="html-italic">J Allergy Clin Immunol 2010, 126, (5), 898-907; quiz 08-9</span>.</li> <li id="B95-preprints-107672" class="html-xx" data-content="95.">Seneff, S.; Nigh, G. , Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19. <span class="html-italic">International Journal of Vaccine Theory, Practice, and Research 2021, 2, (1), 38-79</span>.</li> <li id="B96-preprints-107672" class="html-xx" data-content="96.">Bernardini, A.; Gigli, G. L.; Janes, F.; Pellitteri, G.; Ciardi, C.; Fabris, M.; Valente, M. , Creutzfeldt-Jakob disease after COVID-19: infection-induced prion protein misfolding? A case report. <span class="html-italic">Prion</span> <b>2022</b>, <span class="html-italic">16</span>, 78–83. [<a href="https://scholar.google.com/scholar_lookup?title=,+Creutzfeldt-Jakob+disease+after+COVID-19:+infection-induced+prion+protein+misfolding?+A+case+report&author=Bernardini,+A.&author=Gigli,+G.+L.&author=Janes,+F.&author=Pellitteri,+G.&author=Ciardi,+C.&author=Fabris,+M.&author=Valente,+M.&publication_year=2022&journal=Prion&volume=16&pages=78%E2%80%9383&doi=10.1080/19336896.2022.2095185" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1080/19336896.2022.2095185" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B97-preprints-107672" class="html-xx" data-content="97.">Lukiw, W. J.; Jaber, V. R.; Pogue, A. I.; Zhao, Y. , SARS-CoV-2 Invasion and Pathological Links to Prion Disease. <span class="html-italic">Biomolecules</span> <b>2022</b>, 12. [<a href="https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Invasion+and+Pathological+Links+to+Prion+Disease&author=Lukiw,+W.+J.&author=Jaber,+V.+R.&author=Pogue,+A.+I.&author=Zhao,+Y.&publication_year=2022&journal=Biomolecules&pages=12&doi=10.3390/biom12091253" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/biom12091253" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B98-preprints-107672" class="html-xx" data-content="98.">Tetz, G.; Tetz, V. , Prion-like Domains in Spike Protein of SARS-CoV-2 Differ across Its Variants and Enable Changes in Affinity to ACE2. <span class="html-italic">Microorganisms</span> <b>2022</b>, 10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Prion-like+Domains+in+Spike+Protein+of+SARS-CoV-2+Differ+across+Its+Variants+and+Enable+Changes+in+Affinity+to+ACE2&author=Tetz,+G.&author=Tetz,+V.&publication_year=2022&journal=Microorganisms&pages=10&doi=10.3390/microorganisms10020280" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/microorganisms10020280" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B99-preprints-107672" class="html-xx" data-content="99.">Makhoul, K.; Beeber, T.; Cordero, R.; Khan, A.; Saliaj, M. , Prion Disease After COVID-19: A Case Report. <span class="html-italic">Am J Case Rep</span> <b>2023</b>, <span class="html-italic">24</span>, e940564. [<a href="https://scholar.google.com/scholar_lookup?title=,+Prion+Disease+After+COVID-19:+A+Case+Report&author=Makhoul,+K.&author=Beeber,+T.&author=Cordero,+R.&author=Khan,+A.&author=Saliaj,+M.&publication_year=2023&journal=Am+J+Case+Rep&volume=24&pages=e940564&doi=10.12659/AJCR.940564&pmid=37731242" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.12659/AJCR.940564" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/37731242" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B100-preprints-107672" class="html-xxx" data-content="100.">Perez, J.-C.; Moret-Chalmin, C.; Montagnier, L. , Emergence of a New Creutzfeldt-Jakob Disease: 26 Cases of the Human Version of Mad-Cow Disease, Days After a COVID-19 Injection. <span class="html-italic">International Journal of Vaccine Theory, Practice, and Research 2023, 3, (1), 727-70</span>.</li> <li id="B101-preprints-107672" class="html-xxx" data-content="101.">Seneff, S.; Kyriakopoulos, A. M.; Nigh, G.; McCullough, P. A. , A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review. <span class="html-italic">Cureus</span> <b>2023</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+A+Potential+Role+of+the+Spike+Protein+in+Neurodegenerative+Diseases:+A+Narrative+Review&author=Seneff,+S.&author=Kyriakopoulos,+A.+M.&author=Nigh,+G.&author=McCullough,+P.+A.&publication_year=2023&journal=Cureus&doi=10.7759/cureus.34872&pmid=36788995" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.7759/cureus.34872" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36788995" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B102-preprints-107672" class="html-xxx" data-content="102.">Perez, J. C.; Lounnas, V.; Montagnier, M. , The Omicron Variant Breaks the Evolutionary Lineage of Sars-Cov2 Variants. <span class="html-italic">International Journal of Research -GRANTHAALAYAH 2021, 9, (12), 108-32</span>.</li> <li id="B103-preprints-107672" class="html-xxx" data-content="103.">Chapman, C. W., S. , Project risk management: Process, techniques and insight. Wiley: London, UK, 2003.</li> <li id="B104-preprints-107672" class="html-xxx" data-content="104.">Aven, T. , Risk assessment and risk management: Review of recent advances on their foundation. <span class="html-italic">European Journal of Operational Research</span> <b>2016</b>, <span class="html-italic">253</span>, 1–13. [<a href="https://scholar.google.com/scholar_lookup?title=,+Risk+assessment+and+risk+management:+Review+of+recent+advances+on+their+foundation&author=Aven,+T.&publication_year=2016&journal=European+Journal+of+Operational+Research&volume=253&pages=1%E2%80%9313&doi=10.1016/j.ejor.2015.12.023" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ejor.2015.12.023" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B105-preprints-107672" class="html-xxx" data-content="105.">Watson, N.; Brandel, J.-P.; Green, A.; Hermann, P.; Ladogana, A.; Lindsay, T.; Mackenzie, J.; Pocchiari, M.; Smith, C.; Zerr, I.; Pal, S. , The importance of ongoing international surveillance for Creutzfeldt–Jakob disease. <span class="html-italic">Nature Reviews Neurology</span> <b>2021</b>, <span class="html-italic">17</span>, 362–79. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+importance+of+ongoing+international+surveillance+for+Creutzfeldt%E2%80%93Jakob+disease&author=Watson,+N.&author=Brandel,+J.-P.&author=Green,+A.&author=Hermann,+P.&author=Ladogana,+A.&author=Lindsay,+T.&author=Mackenzie,+J.&author=Pocchiari,+M.&author=Smith,+C.&author=Zerr,+I.&publication_year=2021&journal=Nature+Reviews+Neurology&volume=17&pages=362%E2%80%9379&doi=10.1038/s41582-021-00488-7&pmid=33972773" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41582-021-00488-7" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33972773" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B106-preprints-107672" class="html-xxx" data-content="106.">Moghimi, S. M.; Simberg, D. , Pro-inflammatory concerns with lipid nanoparticles. <span class="html-italic">Molecular Therapy</span> <b>2022</b>, <span class="html-italic">30</span>, 2109–10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Pro-inflammatory+concerns+with+lipid+nanoparticles&author=Moghimi,+S.+M.&author=Simberg,+D.&publication_year=2022&journal=Molecular+Therapy&volume=30&pages=2109%E2%80%9310&doi=10.1016/j.ymthe.2022.04.011&pmid=35487214" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ymthe.2022.04.011" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35487214" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B107-preprints-107672" class="html-xxx" data-content="107.">Tahtinen, S.; Tong, A.-J.; Himmels, P.; Oh, J.; Paler-Martinez, A.; Kim, L.; Wichner, S.; Oei, Y.; McCarron, M. J.; Freund, E. C.; Amir, Z. A.; de la Cruz, C. C.; Haley, B.; Blanchette, C.; Schartner, J. M.; Ye, W.; Yadav, M.; Sahin, U.; Delamarre, L.; Mellman, I. , IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. <span class="html-italic">Nature Immunology</span> <b>2022</b>, <span class="html-italic">23</span>, 532–42. [<a href="https://scholar.google.com/scholar_lookup?title=,+IL-1+and+IL-1ra+are+key+regulators+of+the+inflammatory+response+to+RNA+vaccines&author=Tahtinen,+S.&author=Tong,+A.-J.&author=Himmels,+P.&author=Oh,+J.&author=Paler-Martinez,+A.&author=Kim,+L.&author=Wichner,+S.&author=Oei,+Y.&author=McCarron,+M.+J.&author=Freund,+E.+C.&publication_year=2022&journal=Nature+Immunology&volume=23&pages=532%E2%80%9342&doi=10.1038/s41590-022-01160-y&pmid=35332327" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41590-022-01160-y" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35332327" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B108-preprints-107672" class="html-xxx" data-content="108.">Halma, M. T. J.; Rose, J.; Lawrie, T. , The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review. <span class="html-italic">J</span> <b>2023</b>, <span class="html-italic">6</span>, 220–35. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+Novelty+of+mRNA+Viral+Vaccines+and+Potential+Harms:+A+Scoping+Review&author=Halma,+M.+T.+J.&author=Rose,+J.&author=Lawrie,+T.&publication_year=2023&journal=J&volume=6&pages=220%E2%80%9335&doi=10.3390/j6020017" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/j6020017" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B109-preprints-107672" class="html-xxx" data-content="109.">Bakos, T.; Meszaros, T.; Kozma, G. T.; Berenyi, P.; Facsko, R.; Farkas, H.; Dezsi, L.; Heirman, C.; de Koker, S.; Schiffelers, R.; Glatter, K. A.; Radovits, T.; Szenasi, G.; Szebeni, J. , mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions. <span class="html-italic">Int J Mol Sci</span> <b>2024</b>, 25. [<a href="https://scholar.google.com/scholar_lookup?title=,+mRNA-LNP+COVID-19+Vaccine+Lipids+Induce+Complement+Activation+and+Production+of+Proinflammatory+Cytokines:+Mechanisms,+Effects+of+Complement+Inhibitors,+and+Relevance+to+Adverse+Reactions&author=Bakos,+T.&author=Meszaros,+T.&author=Kozma,+G.+T.&author=Berenyi,+P.&author=Facsko,+R.&author=Farkas,+H.&author=Dezsi,+L.&author=Heirman,+C.&author=de+Koker,+S.&author=Schiffelers,+R.&publication_year=2024&journal=Int+J+Mol+Sci&pages=25&doi=10.3390/ijms25073595&pmid=38612407" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/ijms25073595" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/38612407" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B110-preprints-107672" class="html-xxx" data-content="110.">Moghimi, S. M. , Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. <span class="html-italic">Molecular Therapy</span> <b>2021</b>, <span class="html-italic">29</span>, 898–900. [<a href="https://scholar.google.com/scholar_lookup?title=,+Allergic+Reactions+and+Anaphylaxis+to+LNP-Based+COVID-19+Vaccines&author=Moghimi,+S.+M.&publication_year=2021&journal=Molecular+Therapy&volume=29&pages=898%E2%80%93900&doi=10.1016/j.ymthe.2021.01.030" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ymthe.2021.01.030" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B111-preprints-107672" class="html-xxx" data-content="111.">Faizullin, D.; Valiullina, Y.; Salnikov, V.; Zuev, Y. , Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. <span class="html-italic">Nanomedicine</span> <b>2020</b>, <span class="html-italic">23</span>, 102098. [<a href="https://scholar.google.com/scholar_lookup?title=,+Direct+interaction+of+fibrinogen+with+lipid+microparticles+modulates+clotting+kinetics+and+clot+structure&author=Faizullin,+D.&author=Valiullina,+Y.&author=Salnikov,+V.&author=Zuev,+Y.&publication_year=2020&journal=Nanomedicine&volume=23&pages=102098&doi=10.1016/j.nano.2019.102098" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.nano.2019.102098" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B112-preprints-107672" class="html-xxx" data-content="112.">Stark, K.; Massberg, S. , Interplay between inflammation and thrombosis in cardiovascular pathology. <span class="html-italic">Nat Rev Cardiol</span> <b>2021</b>, <span class="html-italic">18</span>, 666–82. [<a href="https://scholar.google.com/scholar_lookup?title=,+Interplay+between+inflammation+and+thrombosis+in+cardiovascular+pathology&author=Stark,+K.&author=Massberg,+S.&publication_year=2021&journal=Nat+Rev+Cardiol&volume=18&pages=666%E2%80%9382&doi=10.1038/s41569-021-00552-1&pmid=33958774" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41569-021-00552-1" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33958774" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B113-preprints-107672" class="html-xxx" data-content="113.">Maltezou, H. C.; Pavli, A.; Tsakris, A. , Post-COVID Syndrome: An Insight on Its Pathogenesis. <span class="html-italic">Vaccines</span> <b>2021</b>, 9. [<a href="https://scholar.google.com/scholar_lookup?title=,+Post-COVID+Syndrome:+An+Insight+on+Its+Pathogenesis&author=Maltezou,+H.+C.&author=Pavli,+A.&author=Tsakris,+A.&publication_year=2021&journal=Vaccines&pages=9&doi=10.3390/vaccines9050497&pmid=34066007" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/vaccines9050497" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34066007" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B114-preprints-107672" class="html-xxx" data-content="114.">Theoharides, T. C. , Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? <span class="html-italic">Molecular Neurobiology</span> <b>2022</b>, <span class="html-italic">59</span>, 1850–61. [<a href="https://scholar.google.com/scholar_lookup?title=,+Could+SARS-CoV-2+Spike+Protein+Be+Responsible+for+Long-COVID+Syndrome?&author=Theoharides,+T.+C.&publication_year=2022&journal=Molecular+Neurobiology&volume=59&pages=1850%E2%80%9361&doi=10.1007/s12035-021-02696-0&pmid=35028901" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1007/s12035-021-02696-0" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35028901" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B115-preprints-107672" class="html-xxx" data-content="115.">Greene, C.; Connolly, R.; Brennan, D.; Laffan, A.; O'Keeffe, E.; Zaporojan, L.; O'Callaghan, J.; Thomson, B.; Connolly, E.; Argue, R.; Martin-Loeches, I.; Long, A.; Cheallaigh, C. N.; Conlon, N.; Doherty, C. P.; Campbell, M. , Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment. <span class="html-italic">Nat Neurosci</span> <b>2024</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+Blood-brain+barrier+disruption+and+sustained+systemic+inflammation+in+individuals+with+long+COVID-associated+cognitive+impairment&author=Greene,+C.&author=Connolly,+R.&author=Brennan,+D.&author=Laffan,+A.&author=O'Keeffe,+E.&author=Zaporojan,+L.&author=O'Callaghan,+J.&author=Thomson,+B.&author=Connolly,+E.&author=Argue,+R.&publication_year=2024&journal=Nat+Neurosci" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>]</li> <li id="B116-preprints-107672" class="html-xxx" data-content="116.">Houston, F.; Foster, J. D.; Chong, A.; Hunter, N.; Bostock, C. J. , Transmission of BSE by blood transfusion in sheep. <span class="html-italic">Lancet</span> <b>2000</b>, <span class="html-italic">356</span>, 999–1000. [<a href="https://scholar.google.com/scholar_lookup?title=,+Transmission+of+BSE+by+blood+transfusion+in+sheep&author=Houston,+F.&author=Foster,+J.+D.&author=Chong,+A.&author=Hunter,+N.&author=Bostock,+C.+J.&publication_year=2000&journal=Lancet&volume=356&pages=999%E2%80%931000&doi=10.1016/S0140-6736(00)02719-7&pmid=11041403" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/S0140-6736(00)02719-7" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11041403" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B117-preprints-107672" class="html-xxx" data-content="117.">Hunter, N.; Foster, J.; Chong, A.; McCutcheon, S.; Parnham, D.; Eaton, S.; MacKenzie, C.; Houston, F. , Transmission of prion diseases by blood transfusion. <span class="html-italic">J Gen Virol</span> <b>2002</b>, <span class="html-italic">(Pt 11)</span> <span class="html-italic">Pt 11</span>, 2897–905. [<a href="https://scholar.google.com/scholar_lookup?title=,+Transmission+of+prion+diseases+by+blood+transfusion&author=Hunter,+N.&author=Foster,+J.&author=Chong,+A.&author=McCutcheon,+S.&author=Parnham,+D.&author=Eaton,+S.&author=MacKenzie,+C.&author=Houston,+F.&publication_year=2002&journal=J+Gen+Virol&volume=(Pt+11)&issue=Pt+11&pages=2897%E2%80%93905&doi=10.1099/0022-1317-83-11-2897" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1099/0022-1317-83-11-2897" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B118-preprints-107672" class="html-xxx" data-content="118.">Seki, Y.; Yamazaki, Y.; Inoue, Y.; Wakabayashi, C.; Seto, S. , How HIV infected haemophiliacs in Japan were informed of their HIV-positive status. <span class="html-italic">AIDS Care</span> <b>2002</b>, <span class="html-italic">14</span>, 651–64. [<a href="https://scholar.google.com/scholar_lookup?title=,+How+HIV+infected+haemophiliacs+in+Japan+were+informed+of+their+HIV-positive+status&author=Seki,+Y.&author=Yamazaki,+Y.&author=Inoue,+Y.&author=Wakabayashi,+C.&author=Seto,+S.&publication_year=2002&journal=AIDS+Care&volume=14&pages=651%E2%80%9364&doi=10.1080/0954012021000005489&pmid=12419115" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1080/0954012021000005489" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/12419115" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B119-preprints-107672" class="html-xxx" data-content="119.">Llewelyn, C. A.; Hewitt, P. E.; Knight, R. S.; Amar, K.; Cousens, S.; Mackenzie, J.; Will, R. G. , Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. <span class="html-italic">Lancet</span> <b>2004</b>, <span class="html-italic">363</span>, 417–21. [<a href="https://scholar.google.com/scholar_lookup?title=,+Possible+transmission+of+variant+Creutzfeldt-Jakob+disease+by+blood+transfusion&author=Llewelyn,+C.+A.&author=Hewitt,+P.+E.&author=Knight,+R.+S.&author=Amar,+K.&author=Cousens,+S.&author=Mackenzie,+J.&author=Will,+R.+G.&publication_year=2004&journal=Lancet&volume=363&pages=417%E2%80%9321&doi=10.1016/S0140-6736(04)15486-X&pmid=14962520" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/S0140-6736(04)15486-X" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/14962520" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B120-preprints-107672" class="html-xxx" data-content="120.">Cullinane, J. , Tainted Blood and Vengeful Spirits: The Legacy of Japan’s Yakugai Eizu (AIDS) Trial. <span class="html-italic">Culture, Medicine and Psychiatry 2005, 29, (1), 5-31</span>.</li> <li id="B121-preprints-107672" class="html-xxx" data-content="121.">Hewitt, P. E.; Llewelyn, C. A.; Mackenzie, J.; Will, R. G. , Creutzfeldt–Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. <span class="html-italic">Vox Sanguinis</span> <b>2006</b>, <span class="html-italic">91</span>, 221–30. [<a href="https://scholar.google.com/scholar_lookup?title=,+Creutzfeldt%E2%80%93Jakob+disease+and+blood+transfusion:+results+of+the+UK+Transfusion+Medicine+Epidemiological+Review+study&author=Hewitt,+P.+E.&author=Llewelyn,+C.+A.&author=Mackenzie,+J.&author=Will,+R.+G.&publication_year=2006&journal=Vox+Sanguinis&volume=91&pages=221%E2%80%9330&doi=10.1111/j.1423-0410.2006.00833.x" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/j.1423-0410.2006.00833.x" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B122-preprints-107672" class="html-xxx" data-content="122.">McLeod, N. P.; Nugent, P.; Dixon, D.; Dennis, M.; Cornwall, M.; Mallinson, G.; Watkins, N.; Thomas, S.; Sutton, J. M. , Evaluation of efficacy of prion reduction filters using blood from an endogenously infected 263K scrapie hamster model. <span class="html-italic">Transfusion</span> <b>2015</b>, <span class="html-italic">55</span>, 2390–7. [<a href="https://scholar.google.com/scholar_lookup?title=,+Evaluation+of+efficacy+of+prion+reduction+filters+using+blood+from+an+endogenously+infected+263K+scrapie+hamster+model&author=McLeod,+N.+P.&author=Nugent,+P.&author=Dixon,+D.&author=Dennis,+M.&author=Cornwall,+M.&author=Mallinson,+G.&author=Watkins,+N.&author=Thomas,+S.&author=Sutton,+J.+M.&publication_year=2015&journal=Transfusion&volume=55&pages=2390%E2%80%937&doi=10.1111/trf.13172" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/trf.13172" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B123-preprints-107672" class="html-xxx" data-content="123.">Seed, C. R.; Hewitt, P. E.; Dodd, R. Y.; Houston, F.; Cervenakova, L. , Creutzfeldt-Jakob disease and blood transfusion safety. <span class="html-italic">Vox Sanguinis</span> <b>2018</b>, <span class="html-italic">113</span>, 220–31. [<a href="https://scholar.google.com/scholar_lookup?title=,+Creutzfeldt-Jakob+disease+and+blood+transfusion+safety&author=Seed,+C.+R.&author=Hewitt,+P.+E.&author=Dodd,+R.+Y.&author=Houston,+F.&author=Cervenakova,+L.&publication_year=2018&journal=Vox+Sanguinis&volume=113&pages=220%E2%80%9331&doi=10.1111/vox.12631&pmid=29359329" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/vox.12631" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/29359329" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B124-preprints-107672" class="html-xxx" data-content="124.">Tighe, P. J.; Ryder, R. R.; Todd, I.; Fairclough, L. C. , ELISA in the multiplex era: Potentials and pitfalls. <span class="html-italic">PROTEOMICS – Clinical Applications 2015, 9, (3-4), 406-22</span>.</li> <li id="B125-preprints-107672" class="html-xxx" data-content="125.">Macklin, A.; Khan, S.; Kislinger, T. , Recent advances in mass spectrometry based clinical proteomics: applications to cancer research. <span class="html-italic">Clinical Proteomics</span> <b>2020</b>, 17. [<a href="https://scholar.google.com/scholar_lookup?title=,+Recent+advances+in+mass+spectrometry+based+clinical+proteomics:+applications+to+cancer+research&author=Macklin,+A.&author=Khan,+S.&author=Kislinger,+T.&publication_year=2020&journal=Clinical+Proteomics&pages=17&doi=10.1186/s12014-020-09283-w&pmid=32489335" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1186/s12014-020-09283-w" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/32489335" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B126-preprints-107672" class="html-xxx" data-content="126.">Wang, D.; Baudys, J.; Bundy, J. L.; Solano, M.; Keppel, T.; Barr, J. R. , Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry. <span class="html-italic">Analytical Chemistry</span> <b>2020</b>, <span class="html-italic">92</span>, 14730–39. [<a href="https://scholar.google.com/scholar_lookup?title=,+Comprehensive+Analysis+of+the+Glycan+Complement+of+SARS-CoV-2+Spike+Proteins+Using+Signature+Ions-Triggered+Electron-Transfer/Higher-Energy+Collisional+Dissociation+(EThcD)+Mass+Spectrometry&author=Wang,+D.&author=Baudys,+J.&author=Bundy,+J.+L.&author=Solano,+M.&author=Keppel,+T.&author=Barr,+J.+R.&publication_year=2020&journal=Analytical+Chemistry&volume=92&pages=14730%E2%80%9339&doi=10.1021/acs.analchem.0c03301&pmid=33064451" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1021/acs.analchem.0c03301" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33064451" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B127-preprints-107672" class="html-xxx" data-content="127.">Zhou, B.; Xu, K.; Zheng, X.; Chen, T.; Wang, J.; Song, Y.; Shao, Y.; Zheng, S. , Application of exosomes as liquid biopsy in clinical diagnosis. <span class="html-italic">Signal Transduction and Targeted Therapy</span> <b>2020</b>, 5. [<a href="https://scholar.google.com/scholar_lookup?title=,+Application+of+exosomes+as+liquid+biopsy+in+clinical+diagnosis&author=Zhou,+B.&author=Xu,+K.&author=Zheng,+X.&author=Chen,+T.&author=Wang,+J.&author=Song,+Y.&author=Shao,+Y.&author=Zheng,+S.&publication_year=2020&journal=Signal+Transduction+and+Targeted+Therapy&pages=5&doi=10.1038/s41392-020-00258-9&pmid=32747657" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41392-020-00258-9" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/32747657" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B128-preprints-107672" class="html-xxx" data-content="128.">Mustafa Hellou, M.; Górska, A.; Mazzaferri, F.; Cremonini, E.; Gentilotti, E.; De Nardo, P.; Poran, I.; Leeflang, M. M.; Tacconelli, E.; Paul, M. , Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysis. <span class="html-italic">Clinical Microbiology and Infection</span> <b>2021</b>, <span class="html-italic">27</span>, 341–51. [<a href="https://scholar.google.com/scholar_lookup?title=,+Nucleic+acid+amplification+tests+on+respiratory+samples+for+the+diagnosis+of+coronavirus+infections:+a+systematic+review+and+meta-analysis&author=Mustafa+Hellou,+M.&author=G%C3%B3rska,+A.&author=Mazzaferri,+F.&author=Cremonini,+E.&author=Gentilotti,+E.&author=De+Nardo,+P.&author=Poran,+I.&author=Leeflang,+M.+M.&author=Tacconelli,+E.&author=Paul,+M.&publication_year=2021&journal=Clinical+Microbiology+and+Infection&volume=27&pages=341%E2%80%9351&doi=10.1016/j.cmi.2020.11.002&pmid=33188933" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.cmi.2020.11.002" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33188933" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B129-preprints-107672" class="html-xxx" data-content="129.">Ding, Z.; Wang, N.; Ji, N.; Chen, Z.-S. , Proteomics technologies for cancer liquid biopsies. <span class="html-italic">Molecular Cancer</span> <b>2022</b>, 21. [<a href="https://scholar.google.com/scholar_lookup?title=,+Proteomics+technologies+for+cancer+liquid+biopsies&author=Ding,+Z.&author=Wang,+N.&author=Ji,+N.&author=Chen,+Z.-S.&publication_year=2022&journal=Molecular+Cancer&pages=21&doi=10.1186/s12943-022-01526-8&pmid=35168611" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1186/s12943-022-01526-8" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35168611" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B130-preprints-107672" class="html-xxx" data-content="130.">Pu, R.; Liu, S.; Ren, X.; Shi, D.; Ba, Y.; Huo, Y.; Zhang, W.; Ma, L.; Liu, Y.; Yang, Y.; Cheng, N. , The screening value of RT-LAMP and RT-PCR in the diagnosis of COVID-19: systematic review and meta-analysis. <span class="html-italic">J Virol Methods</span> <b>2022</b>, <span class="html-italic">300</span>, 114392. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+screening+value+of+RT-LAMP+and+RT-PCR+in+the+diagnosis+of+COVID-19:+systematic+review+and+meta-analysis&author=Pu,+R.&author=Liu,+S.&author=Ren,+X.&author=Shi,+D.&author=Ba,+Y.&author=Huo,+Y.&author=Zhang,+W.&author=Ma,+L.&author=Liu,+Y.&author=Yang,+Y.&publication_year=2022&journal=J+Virol+Methods&volume=300&pages=114392&doi=10.1016/j.jviromet.2021.114392&pmid=34856308" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.jviromet.2021.114392" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34856308" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B131-preprints-107672" class="html-xxx" data-content="131.">Bhardwaj, T.; Gadhave, K.; Kapuganti, S. K.; Kumar, P.; Brotzakis, Z. F.; Saumya, K. U.; Nayak, N.; Kumar, A.; Joshi, R.; Mukherjee, B.; Bhardwaj, A.; Thakur, K. G.; Garg, N.; Vendruscolo, M.; Giri, R. , Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. <span class="html-italic">Nature Communications</span> <b>2023</b>, 14. [<a href="https://scholar.google.com/scholar_lookup?title=,+Amyloidogenic+proteins+in+the+SARS-CoV+and+SARS-CoV-2+proteomes&author=Bhardwaj,+T.&author=Gadhave,+K.&author=Kapuganti,+S.+K.&author=Kumar,+P.&author=Brotzakis,+Z.+F.&author=Saumya,+K.+U.&author=Nayak,+N.&author=Kumar,+A.&author=Joshi,+R.&author=Mukherjee,+B.&publication_year=2023&journal=Nature+Communications&pages=14&doi=10.1038/s41467-023-36234-4&pmid=36806058" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41467-023-36234-4" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/36806058" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B132-preprints-107672" class="html-xxx" data-content="132.">Pan, K. M.; Baldwin, M.; Nguyen, J.; Gasset, M.; Serban, A.; Groth, D.; Mehlhorn, I.; Huang, Z.; Fletterick, R. J.; Cohen, F. E. , Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. <span class="html-italic">Proceedings of the National Academy of Sciences</span> <b>1993</b>, <span class="html-italic">90</span>, 10962–66. [<a href="https://scholar.google.com/scholar_lookup?title=,+Conversion+of+alpha-helices+into+beta-sheets+features+in+the+formation+of+the+scrapie+prion+proteins&author=Pan,+K.+M.&author=Baldwin,+M.&author=Nguyen,+J.&author=Gasset,+M.&author=Serban,+A.&author=Groth,+D.&author=Mehlhorn,+I.&author=Huang,+Z.&author=Fletterick,+R.+J.&author=Cohen,+F.+E.&publication_year=1993&journal=Proceedings+of+the+National+Academy+of+Sciences&volume=90&pages=10962%E2%80%9366&doi=10.1073/pnas.90.23.10962" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1073/pnas.90.23.10962" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B133-preprints-107672" class="html-xxx" data-content="133.">133. Langeveld, Jan P. M.; Wang, J. J.; Van de Wiel, Dick F. M.; Shih, Giles C.; Garssen, G. J.; Bossers, A.; Shih, Jason C. H., Enzymatic Degradation of Prion Protein in Brain Stem from Infected Cattle and Sheep. <span class="html-italic">The Journal of Infectious Diseases 2003, 188, (11), 1782-89</span>.</li> <li id="B134-preprints-107672" class="html-xxx" data-content="134.">Prusiner, S. B.; Groth, D. F.; McKinley, M. P.; Cochran, S. P.; Bowman, K. A.; Kasper, K. C. , Thiocyanate and hydroxyl ions inactivate the scrapie agent. <span class="html-italic">Proceedings of the National Academy of Sciences</span> <b>1981</b>, <span class="html-italic">78</span>, 4606–10. [<a href="https://scholar.google.com/scholar_lookup?title=,+Thiocyanate+and+hydroxyl+ions+inactivate+the+scrapie+agent&author=Prusiner,+S.+B.&author=Groth,+D.+F.&author=McKinley,+M.+P.&author=Cochran,+S.+P.&author=Bowman,+K.+A.&author=Kasper,+K.+C.&publication_year=1981&journal=Proceedings+of+the+National+Academy+of+Sciences&volume=78&pages=4606%E2%80%9310&doi=10.1073/pnas.78.7.4606" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1073/pnas.78.7.4606" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B135-preprints-107672" class="html-xxx" data-content="135.">Race, R. E.; Raymond, G. J. , Inactivation of Transmissible Spongiform Encephalopathy (Prion) Agents by Environ LpH. <span class="html-italic">Journal of Virology</span> <b>2004</b>, <span class="html-italic">78</span>, 2164–65. [<a href="https://scholar.google.com/scholar_lookup?title=,+Inactivation+of+Transmissible+Spongiform+Encephalopathy+(Prion)+Agents+by+Environ+LpH&author=Race,+R.+E.&author=Raymond,+G.+J.&publication_year=2004&journal=Journal+of+Virology&volume=78&pages=2164%E2%80%9365&doi=10.1128/JVI.78.4.2164-2165.2004&pmid=14747583" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1128/JVI.78.4.2164-2165.2004" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/14747583" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B136-preprints-107672" class="html-xxx" data-content="136.">Peretz, D.; Supattapone, S.; Giles, K.; Vergara, J.; Freyman, Y.; Lessard, P.; Safar, J. G.; Glidden, D. V.; McCulloch, C.; Nguyen, H.-O. B.; Scott, M.; DeArmond, S. J.; Prusiner, S. B. , Inactivation of Prions by Acidic Sodium Dodecyl Sulfate. <span class="html-italic">Journal of Virology</span> <b>2006</b>, <span class="html-italic">80</span>, 322–31. [<a href="https://scholar.google.com/scholar_lookup?title=,+Inactivation+of+Prions+by+Acidic+Sodium+Dodecyl+Sulfate&author=Peretz,+D.&author=Supattapone,+S.&author=Giles,+K.&author=Vergara,+J.&author=Freyman,+Y.&author=Lessard,+P.&author=Safar,+J.+G.&author=Glidden,+D.+V.&author=McCulloch,+C.&author=Nguyen,+H.-O.+B.&publication_year=2006&journal=Journal+of+Virology&volume=80&pages=322%E2%80%9331&doi=10.1128/JVI.80.1.322-331.2006&pmid=16352557" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1128/JVI.80.1.322-331.2006" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16352557" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B137-preprints-107672" class="html-xxx" data-content="137.">Tanikawa, T.; Kiba, Y.; Yu, J.; Hsu, K.; Chen, S.; Ishii, A.; Yokogawa, T.; Suzuki, R.; Inoue, Y.; Kitamura, M. , Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. <span class="html-italic">Molecules</span> <b>2022</b>, 27. [<a href="https://scholar.google.com/scholar_lookup?title=,+Degradative+Effect+of+Nattokinase+on+Spike+Protein+of+SARS-CoV-2&author=Tanikawa,+T.&author=Kiba,+Y.&author=Yu,+J.&author=Hsu,+K.&author=Chen,+S.&author=Ishii,+A.&author=Yokogawa,+T.&author=Suzuki,+R.&author=Inoue,+Y.&author=Kitamura,+M.&publication_year=2022&journal=Molecules&pages=27&doi=10.3390/molecules27175405" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/molecules27175405" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B138-preprints-107672" class="html-xxx" data-content="138.">Tai, M. W.; Sweet, B. V. , Nattokinase for prevention of thrombosis. <span class="html-italic">Am J Health Syst Pharm</span> <b>2006</b>, <span class="html-italic">63</span>, 1121–3. [<a href="https://scholar.google.com/scholar_lookup?title=,+Nattokinase+for+prevention+of+thrombosis&author=Tai,+M.+W.&author=Sweet,+B.+V.&publication_year=2006&journal=Am+J+Health+Syst+Pharm&volume=63&pages=1121%E2%80%933&doi=10.2146/ajhp050509&pmid=16754735" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.2146/ajhp050509" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16754735" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B139-preprints-107672" class="html-xxx" data-content="139.">Weng, Y.; Yao, J.; Sparks, S.; Wang, K. Y. , Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. <span class="html-italic">Int J Mol Sci</span> <b>2017</b>, 18. [<a href="https://scholar.google.com/scholar_lookup?title=,+Nattokinase:+An+Oral+Antithrombotic+Agent+for+the+Prevention+of+Cardiovascular+Disease&author=Weng,+Y.&author=Yao,+J.&author=Sparks,+S.&author=Wang,+K.+Y.&publication_year=2017&journal=Int+J+Mol+Sci&pages=18&doi=10.3390/ijms18030523&pmid=28264497" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/ijms18030523" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/28264497" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B140-preprints-107672" class="html-xxx" data-content="140.">Chen, H.; McGowan, E. M.; Ren, N.; Lal, S.; Nassif, N.; Shad-Kaneez, F.; Qu, X.; Lin, Y. , Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. <span class="html-italic">Biomark Insights</span> <b>2018</b>, <span class="html-italic">13</span>, 1177271918785130. [<a href="https://scholar.google.com/scholar_lookup?title=,+Nattokinase:+A+Promising+Alternative+in+Prevention+and+Treatment+of+Cardiovascular+Diseases&author=Chen,+H.&author=McGowan,+E.+M.&author=Ren,+N.&author=Lal,+S.&author=Nassif,+N.&author=Shad-Kaneez,+F.&author=Qu,+X.&author=Lin,+Y.&publication_year=2018&journal=Biomark+Insights&volume=13&pages=1177271918785130&doi=10.1177/1177271918785130&pmid=30013308" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1177/1177271918785130" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/30013308" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B141-preprints-107672" class="html-xxx" data-content="141.">Schaffner, A.; Risch, L.; Weber, M.; Thiel, S.; Jungert, K.; Pichler, M.; Wohlwend, N.; Lung, T.; Ritzler, M.; Hillmann, D.; Copeland, S.; Renz, H.; Paprotny, M.; Risch, M. , Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study. <span class="html-italic">Clin Chem Lab Med</span> <b>2020</b>, <span class="html-italic">59</span>, e49–e51. [<a href="https://scholar.google.com/scholar_lookup?title=,+Sustained+SARS-CoV-2+nucleocapsid+antibody+levels+in+nonsevere+COVID-19:+a+population-based+study&author=Schaffner,+A.&author=Risch,+L.&author=Weber,+M.&author=Thiel,+S.&author=Jungert,+K.&author=Pichler,+M.&author=Wohlwend,+N.&author=Lung,+T.&author=Ritzler,+M.&author=Hillmann,+D.&publication_year=2020&journal=Clin+Chem+Lab+Med&volume=59&pages=e49%E2%80%93e51&doi=10.1515/cclm-2020-1347" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1515/cclm-2020-1347" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B142-preprints-107672" class="html-xxx" data-content="142.">Chansaenroj, J.; Yorsaeng, R.; Posuwan, N.; Puenpa, J.; Wanlapakorn, N.; Sudhinaraset, N.; Sripramote, M.; Chalongviriyalert, P.; Jirajariyavej, S.; Kiatpanabhikul, P.; Saiyarin, J.; Soudon, C.; Thienfaidee, O.; Palakawong Na Ayuthaya, T.; Brukesawan, C.; Chirathaworn, C.; Intharasongkroh, D.; Chaiwanichsiri, D.; Issarasongkhram, M.; Kitphati, R.; Mungaomklang, A.; Nagavajara, P.; Poovorawan, Y. , Long-term specific IgG response to SARS-CoV-2 nucleocapsid protein in recovered COVID-19 patients. <span class="html-italic">Sci Rep</span> <b>2021</b>, <span class="html-italic">11</span>, 23216. [<a href="https://scholar.google.com/scholar_lookup?title=,+Long-term+specific+IgG+response+to+SARS-CoV-2+nucleocapsid+protein+in+recovered+COVID-19+patients&author=Chansaenroj,+J.&author=Yorsaeng,+R.&author=Posuwan,+N.&author=Puenpa,+J.&author=Wanlapakorn,+N.&author=Sudhinaraset,+N.&author=Sripramote,+M.&author=Chalongviriyalert,+P.&author=Jirajariyavej,+S.&author=Kiatpanabhikul,+P.&publication_year=2021&journal=Sci+Rep&volume=11&pages=23216&doi=10.1038/s41598-021-02659-4" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41598-021-02659-4" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B143-preprints-107672" class="html-xxx" data-content="143.">Van Elslande, J.; Oyaert, M.; Ailliet, S.; Van Ranst, M.; Lorent, N.; Vande Weygaerde, Y.; Andre, E.; Lagrou, K.; Vandendriessche, S.; Vermeersch, P. , Longitudinal follow-up of IgG anti-nucleocapsid antibodies in SARS-CoV-2 infected patients up to eight months after infection. <span class="html-italic">J Clin Virol</span> <b>2021</b>, <span class="html-italic">136</span>, 104765. [<a href="https://scholar.google.com/scholar_lookup?title=,+Longitudinal+follow-up+of+IgG+anti-nucleocapsid+antibodies+in+SARS-CoV-2+infected+patients+up+to+eight+months+after+infection&author=Van+Elslande,+J.&author=Oyaert,+M.&author=Ailliet,+S.&author=Van+Ranst,+M.&author=Lorent,+N.&author=Vande+Weygaerde,+Y.&author=Andre,+E.&author=Lagrou,+K.&author=Vandendriessche,+S.&author=Vermeersch,+P.&publication_year=2021&journal=J+Clin+Virol&volume=136&pages=104765&doi=10.1016/j.jcv.2021.104765" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.jcv.2021.104765" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B144-preprints-107672" class="html-xxx" data-content="144.">Faksova, K.; Walsh, D.; Jiang, Y.; Griffin, J.; Phillips, A.; Gentile, A.; Kwong, J. C.; Macartney, K.; Naus, M.; Grange, Z.; Escolano, S.; Sepulveda, G.; Shetty, A.; Pillsbury, A.; Sullivan, C.; Naveed, Z.; Janjua, N. Z.; Giglio, N.; Perala, J.; Nasreen, S.; Gidding, H.; Hovi, P.; Vo, T.; Cui, F.; Deng, L.; Cullen, L.; Artama, M.; Weintraub, E.; Lu, H.; Clothier, H. J.; Batty, K.; Paynter, J.; Petousis-Harris, H.; Buttery, J.; Black, S.; Hviid, A. , COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals. <span class="html-italic">Vaccine</span> <b>2024</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+COVID-19+vaccines+and+adverse+events+of+special+interest:+A+multinational+Global+Vaccine+Data+Network+(GVDN)+cohort+study+of+99+million+vaccinated+individuals&author=Faksova,+K.&author=Walsh,+D.&author=Jiang,+Y.&author=Griffin,+J.&author=Phillips,+A.&author=Gentile,+A.&author=Kwong,+J.+C.&author=Macartney,+K.&author=Naus,+M.&author=Grange,+Z.&publication_year=2024&journal=Vaccine&doi=10.1016/j.vaccine.2024.01.100" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.vaccine.2024.01.100" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B145-preprints-107672" class="html-xxx" data-content="145.">Stroup, D. F.; Berlin, J. A.; Morton, S. C.; Olkin, I.; Williamson, G. D.; Rennie, D.; Moher, D.; Becker, B. J.; Sipe, T. A.; Thacker, S. B. , Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. <span class="html-italic">JAMA 2000, 283, (15), 2008-12</span>.</li> <li id="B146-preprints-107672" class="html-xxx" data-content="146.">Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G.; Group, P. , Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. <span class="html-italic">Int J Surg</span> <b>2010</b>, <span class="html-italic">8</span>, 336–41. [<a href="https://scholar.google.com/scholar_lookup?title=,+Preferred+reporting+items+for+systematic+reviews+and+meta-analyses:+the+PRISMA+statement&author=Moher,+D.&author=Liberati,+A.&author=Tetzlaff,+J.&author=Altman,+D.+G.&author=Group,+P.&publication_year=2010&journal=Int+J+Surg&volume=8&pages=336%E2%80%9341&doi=10.1016/j.ijsu.2010.02.007" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.ijsu.2010.02.007" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B147-preprints-107672" class="html-xxx" data-content="147.">Murad, M. H.; Montori, V. M.; Ioannidis, J. P.; Jaeschke, R.; Devereaux, P. J.; Prasad, K.; Neumann, I.; Carrasco-Labra, A.; Agoritsas, T.; Hatala, R.; Meade, M. O.; Wyer, P.; Cook, D. J.; Guyatt, G. , How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature. <span class="html-italic">JAMA</span> <b>2014</b>, <span class="html-italic">312</span>, 171–9. [<a href="https://scholar.google.com/scholar_lookup?title=,+How+to+read+a+systematic+review+and+meta-analysis+and+apply+the+results+to+patient+care:+users'+guides+to+the+medical+literature&author=Murad,+M.+H.&author=Montori,+V.+M.&author=Ioannidis,+J.+P.&author=Jaeschke,+R.&author=Devereaux,+P.+J.&author=Prasad,+K.&author=Neumann,+I.&author=Carrasco-Labra,+A.&author=Agoritsas,+T.&author=Hatala,+R.&publication_year=2014&journal=JAMA&volume=312&pages=171%E2%80%939&doi=10.1001/jama.2014.5559" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1001/jama.2014.5559" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B148-preprints-107672" class="html-xxx" data-content="148.">Gould, C. V.; Free, R. J.; Bhatnagar, J.; Soto, R. A.; Royer, T. L.; Maley, W. R.; Moss, S.; Berk, M. A.; Craig-Shapiro, R.; Kodiyanplakkal, R. P. L.; Westblade, L. F.; Muthukumar, T.; Puius, Y. A.; Raina, A.; Hadi, A.; Gyure, K. A.; Trief, D.; Pereira, M.; Kuehnert, M. J.; Ballen, V.; Kessler, D. A.; Dailey, K.; Omura, C.; Doan, T.; Miller, S.; Wilson, M. R.; Lehman, J. A.; Ritter, J. M.; Lee, E.; Silva-Flannery, L.; Reagan-Steiner, S.; Velez, J. O.; Laven, J. J.; Fitzpatrick, K. A.; Panella, A.; Davis, E. H.; Hughes, H. R.; Brault, A. C.; St George, K.; Dean, A. B.; Ackelsberg, J.; Basavaraju, S. V.; Chiu, C. Y.; Staples, J. E.; Yellow Fever Vaccine Virus, T.; Transfusion Investigation, T. , Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation. <span class="html-italic">Lancet Microbe</span> <b>2023</b>, <span class="html-italic">4</span>, e711–e21. [<a href="https://scholar.google.com/scholar_lookup?title=,+Transmission+of+yellow+fever+vaccine+virus+through+blood+transfusion+and+organ+transplantation+in+the+USA+in+2021:+report+of+an+investigation&author=Gould,+C.+V.&author=Free,+R.+J.&author=Bhatnagar,+J.&author=Soto,+R.+A.&author=Royer,+T.+L.&author=Maley,+W.+R.&author=Moss,+S.&author=Berk,+M.+A.&author=Craig-Shapiro,+R.&author=Kodiyanplakkal,+R.+P.+L.&publication_year=2023&journal=Lancet+Microbe&volume=4&pages=e711%E2%80%93e21&doi=10.1016/S2666-5247(23)00170-2" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/S2666-5247(23)00170-2" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B149-preprints-107672" class="html-xxx" data-content="149.">Yaqoob, I.; Salah, K.; Jayaraman, R.; Al-Hammadi, Y. , Blockchain for healthcare data management: opportunities, challenges, and future recommendations. <span class="html-italic">Neural Computing and Applications</span> <b>2021</b>, <span class="html-italic">34</span>, 11475–90. [<a href="https://scholar.google.com/scholar_lookup?title=,+Blockchain+for+healthcare+data+management:+opportunities,+challenges,+and+future+recommendations&author=Yaqoob,+I.&author=Salah,+K.&author=Jayaraman,+R.&author=Al-Hammadi,+Y.&publication_year=2021&journal=Neural+Computing+and+Applications&volume=34&pages=11475%E2%80%9390&doi=10.1007/s00521-020-05519-w" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1007/s00521-020-05519-w" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B150-preprints-107672" class="html-xxx" data-content="150.">Musamih, A.; Salah, K.; Jayaraman, R.; Arshad, J.; Debe, M.; Al-Hammadi, Y.; Ellahham, S. , A Blockchain-Based Approach for Drug Traceability in Healthcare Supply Chain. <span class="html-italic">IEEE Access</span> <b>2021</b>, <span class="html-italic">9</span>, 9728–43. [<a href="https://scholar.google.com/scholar_lookup?title=,+A+Blockchain-Based+Approach+for+Drug+Traceability+in+Healthcare+Supply+Chain&author=Musamih,+A.&author=Salah,+K.&author=Jayaraman,+R.&author=Arshad,+J.&author=Debe,+M.&author=Al-Hammadi,+Y.&author=Ellahham,+S.&publication_year=2021&journal=IEEE+Access&volume=9&pages=9728%E2%80%9343&doi=10.1109/ACCESS.2021.3049920" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1109/ACCESS.2021.3049920" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B151-preprints-107672" class="html-xxx" data-content="151.">WHO, International Health Regulations (2005). 2nd edn. In World Health Organization: Geneva, 2008.</li> <li id="B152-preprints-107672" class="html-xxx" data-content="152.">Bakanidze, L.; Imnadze, P.; Perkins, D. , Biosafety and biosecurity as essential pillars of international health security and cross-cutting elements of biological nonproliferation. <span class="html-italic">BMC Public Health 2010, 10, (Suppl 1)</span>.</li> <li id="B153-preprints-107672" class="html-xxx" data-content="153.">WHO, Global Covid-19 Vaccination Strategy in a Changing World July 2022 update. In World Health Organization: Geneva, 2022.</li> <li id="B154-preprints-107672" class="html-xxx" data-content="154.">Wu, Y. C.; Chen, C. S.; Chan, Y. J. , The outbreak of COVID-19: An overview. <span class="html-italic">J Chin Med Assoc</span> <b>2020</b>, <span class="html-italic">83</span>, 217–20. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+outbreak+of+COVID-19:+An+overview&author=Wu,+Y.+C.&author=Chen,+C.+S.&author=Chan,+Y.+J.&publication_year=2020&journal=J+Chin+Med+Assoc&volume=83&pages=217%E2%80%9320&doi=10.1097/JCMA.0000000000000270" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1097/JCMA.0000000000000270" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B155-preprints-107672" class="html-xxx" data-content="155.">Beeckman, D. S. A.; Rudelsheim, P. , Biosafety and Biosecurity in Containment: A Regulatory Overview. <span class="html-italic">Front Bioeng Biotechnol</span> <b>2020</b>, <span class="html-italic">8</span>, 650. [<a href="https://scholar.google.com/scholar_lookup?title=,+Biosafety+and+Biosecurity+in+Containment:+A+Regulatory+Overview&author=Beeckman,+D.+S.+A.&author=Rudelsheim,+P.&publication_year=2020&journal=Front+Bioeng+Biotechnol&volume=8&pages=650&doi=10.3389/fbioe.2020.00650" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3389/fbioe.2020.00650" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B156-preprints-107672" class="html-xxx" data-content="156.">Berg, P.; Baltimore, D.; Brenner, S.; Roblin, R. O.; Singer, M. F. , Summary statement of the Asilomar conference on recombinant DNA molecules. <span class="html-italic">Proc Natl Acad Sci U S A</span> <b>1975</b>, <span class="html-italic">72</span>, 1981–4. [<a href="https://scholar.google.com/scholar_lookup?title=,+Summary+statement+of+the+Asilomar+conference+on+recombinant+DNA+molecules&author=Berg,+P.&author=Baltimore,+D.&author=Brenner,+S.&author=Roblin,+R.+O.&author=Singer,+M.+F.&publication_year=1975&journal=Proc+Natl+Acad+Sci+U+S+A&volume=72&pages=1981%E2%80%934&doi=10.1073/pnas.72.6.1981" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1073/pnas.72.6.1981" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B157-preprints-107672" class="html-xxx" data-content="157.">Barinaga, M. , Asilomar revisited: lessons for today? <span class="html-italic">Science</span> <b>2000</b>, <span class="html-italic">287</span>, 1584–5. [<a href="https://scholar.google.com/scholar_lookup?title=,+Asilomar+revisited:+lessons+for+today?&author=Barinaga,+M.&publication_year=2000&journal=Science&volume=287&pages=1584%E2%80%935&doi=10.1126/science.287.5458.1584&pmid=10766605" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1126/science.287.5458.1584" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/10766605" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B158-preprints-107672" class="html-xxx" data-content="158.">Krimsky, S. , From Asilomar to industrial biotechnology: risks, reductionism and regulation. <span class="html-italic">Sci Cult (Lond)</span> <b>2005</b>, <span class="html-italic">14</span>, 309–23. [<a href="https://scholar.google.com/scholar_lookup?title=,+From+Asilomar+to+industrial+biotechnology:+risks,+reductionism+and+regulation&author=Krimsky,+S.&publication_year=2005&journal=Sci+Cult+(Lond)&volume=14&pages=309%E2%80%9323&doi=10.1080/09505430500368998&pmid=16619467" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1080/09505430500368998" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16619467" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B159-preprints-107672" class="html-xxx" data-content="159.">Gregorowius, D.; Biller-Andorno, N.; Deplazes-Zemp, A. , The role of scientific self-regulation for the control of genome editing in the human germline: The lessons from the Asilomar and the Napa meetings show how self-regulation and public deliberation can lead to regulation of new biotechnologies. <span class="html-italic">EMBO Rep</span> <b>2017</b>, <span class="html-italic">18</span>, 355–58. [<a href="https://scholar.google.com/scholar_lookup?title=,+The+role+of+scientific+self-regulation+for+the+control+of+genome+editing+in+the+human+germline:+The+lessons+from+the+Asilomar+and+the+Napa+meetings+show+how+self-regulation+and+public+deliberation+can+lead+to+regulation+of+new+biotechnologies&author=Gregorowius,+D.&author=Biller-Andorno,+N.&author=Deplazes-Zemp,+A.&publication_year=2017&journal=EMBO+Rep&volume=18&pages=355%E2%80%9358&doi=10.15252/embr.201643054" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.15252/embr.201643054" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B160-preprints-107672" class="html-xxx" data-content="160.">Taylor, D. M. , Inactivation of TSE agents: safety of blood and blood-derived products. <span class="html-italic">Transfus Clin Biol</span> <b>2003</b>, <span class="html-italic">10</span>, 23–5. [<a href="https://scholar.google.com/scholar_lookup?title=,+Inactivation+of+TSE+agents:+safety+of+blood+and+blood-derived+products&author=Taylor,+D.+M.&publication_year=2003&journal=Transfus+Clin+Biol&volume=10&pages=23%E2%80%935&doi=10.1016/S1246-7820(02)00280-X" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/S1246-7820(02)00280-X" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B161-preprints-107672" class="html-xxx" data-content="161.">Klein, M. A.; Frigg, R.; Flechsig, E.; Raeber, A. J.; Kalinke, U.; Bluethmann, H.; Bootz, F.; Suter, M.; Zinkernagel, R. M.; Aguzzi, A. , A crucial role for B cells in neuroinvasive scrapie. <span class="html-italic">Nature</span> <b>1997</b>, <span class="html-italic">390</span>, 687–90. [<a href="https://scholar.google.com/scholar_lookup?title=,+A+crucial+role+for+B+cells+in+neuroinvasive+scrapie&author=Klein,+M.+A.&author=Frigg,+R.&author=Flechsig,+E.&author=Raeber,+A.+J.&author=Kalinke,+U.&author=Bluethmann,+H.&author=Bootz,+F.&author=Suter,+M.&author=Zinkernagel,+R.+M.&author=Aguzzi,+A.&publication_year=1997&journal=Nature&volume=390&pages=687%E2%80%9390&doi=10.1038/37789" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/37789" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B162-preprints-107672" class="html-xxx" data-content="162.">Singh, S.; Kumar, A. , Leukocyte depletion for safe blood transfusion. <span class="html-italic">Biotechnol J</span> <b>2009</b>, <span class="html-italic">4</span>, 1140–51. [<a href="https://scholar.google.com/scholar_lookup?title=,+Leukocyte+depletion+for+safe+blood+transfusion&author=Singh,+S.&author=Kumar,+A.&publication_year=2009&journal=Biotechnol+J&volume=4&pages=1140%E2%80%9351&doi=10.1002/biot.200800182" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1002/biot.200800182" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B163-preprints-107672" class="html-xxx" data-content="163.">Schmidt, A.; Refaai, M.; Kirkley, S.; Blumberg, N. , Proven and potential clinical benefits of washing red blood cells before transfusion: current perspectives. <span class="html-italic">International Journal of Clinical Transfusion Medicine</span> <b>2016</b>, <span class="html-italic">Volume 4</span>, 79–88. [<a href="https://scholar.google.com/scholar_lookup?title=,+Proven+and+potential+clinical+benefits+of+washing+red+blood+cells+before+transfusion:+current+perspectives&author=Schmidt,+A.&author=Refaai,+M.&author=Kirkley,+S.&author=Blumberg,+N.&publication_year=2016&journal=International+Journal+of+Clinical+Transfusion+Medicine&volume=Volume+4&pages=79%E2%80%9388&doi=10.2147/IJCTM.S101401" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.2147/IJCTM.S101401" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B164-preprints-107672" class="html-xxx" data-content="164.">Cardigan, R.; New, H. V.; Tinegate, H.; Thomas, S. , Washed red cells: theory and practice. <span class="html-italic">Vox Sanguinis</span> <b>2020</b>, <span class="html-italic">115</span>, 606–16. [<a href="https://scholar.google.com/scholar_lookup?title=,+Washed+red+cells:+theory+and+practice&author=Cardigan,+R.&author=New,+H.+V.&author=Tinegate,+H.&author=Thomas,+S.&publication_year=2020&journal=Vox+Sanguinis&volume=115&pages=606%E2%80%9316&doi=10.1111/vox.12971" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/vox.12971" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B165-preprints-107672" class="html-xxx" data-content="165.">Palmqvist, M.; Von Schreeb, J.; Älgå, A. , Autotransfusion in low-resource settings: a scoping review. <span class="html-italic">BMJ Open</span> <b>2022</b>, 12. [<a href="https://scholar.google.com/scholar_lookup?title=,+Autotransfusion+in+low-resource+settings:+a+scoping+review&author=Palmqvist,+M.&author=Von+Schreeb,+J.&author=%C3%84lg%C3%A5,+A.&publication_year=2022&journal=BMJ+Open&pages=12&doi=10.1136/bmjopen-2021-056018" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1136/bmjopen-2021-056018" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B166-preprints-107672" class="html-xxx" data-content="166.">Mulroney, T. E.; Pöyry, T.; Yam-Puc, J. C.; Rust, M.; Harvey, R. F.; Kalmar, L.; Horner, E.; Booth, L.; Ferreira, A. P.; Stoneley, M.; Sawarkar, R.; Mentzer, A. J.; Lilley, K. S.; Smales, C. M.; von der Haar, T.; Turtle, L.; Dunachie, S.; Klenerman, P.; Thaventhiran, J. E. D.; Willis, A. E. , N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. <span class="html-italic">Nature</span> <b>2023</b>. [<a href="https://scholar.google.com/scholar_lookup?title=,+N1-methylpseudouridylation+of+mRNA+causes++1+ribosomal+frameshifting&author=Mulroney,+T.+E.&author=P%C3%B6yry,+T.&author=Yam-Puc,+J.+C.&author=Rust,+M.&author=Harvey,+R.+F.&author=Kalmar,+L.&author=Horner,+E.&author=Booth,+L.&author=Ferreira,+A.+P.&author=Stoneley,+M.&publication_year=2023&journal=Nature&doi=10.1038/s41586-023-06800-3" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1038/s41586-023-06800-3" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B167-preprints-107672" class="html-xxx" data-content="167.">Alameh, M. G.; Tombacz, I.; Bettini, E.; Lederer, K.; Sittplangkoon, C.; Wilmore, J. R.; Gaudette, B. T.; Soliman, O. Y.; Pine, M.; Hicks, P.; Manzoni, T. B.; Knox, J. J.; Johnson, J. L.; Laczko, D.; Muramatsu, H.; Davis, B.; Meng, W.; Rosenfeld, A. M.; Strohmeier, S.; Lin, P. J. C.; Mui, B. L.; Tam, Y. K.; Kariko, K.; Jacquet, A.; Krammer, F.; Bates, P.; Cancro, M. P.; Weissman, D.; Luning Prak, E. T.; Allman, D.; Locci, M.; Pardi, N. , Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. <span class="html-italic">Immunity 2021, 54, (12), 2877-92 e7</span>.</li> <li id="B168-preprints-107672" class="html-xxx" data-content="168.">Guimaraes, L. E.; Baker, B.; Perricone, C.; Shoenfeld, Y. , Vaccines, adjuvants and autoimmunity. <span class="html-italic">Pharmacol Res</span> <b>2015</b>, <span class="html-italic">100</span>, 190–209. [<a href="https://scholar.google.com/scholar_lookup?title=,+Vaccines,+adjuvants+and+autoimmunity&author=Guimaraes,+L.+E.&author=Baker,+B.&author=Perricone,+C.&author=Shoenfeld,+Y.&publication_year=2015&journal=Pharmacol+Res&volume=100&pages=190%E2%80%93209&doi=10.1016/j.phrs.2015.08.003&pmid=26275795" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.phrs.2015.08.003" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/26275795" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B169-preprints-107672" class="html-xxx" data-content="169.">Jara, L. J.; Vera-Lastra, O.; Mahroum, N.; Pineda, C.; Shoenfeld, Y. , Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune/inflammatory syndrome expand? <span class="html-italic">Clinical Rheumatology</span> <b>2022</b>, <span class="html-italic">41</span>, 1603–09. [<a href="https://scholar.google.com/scholar_lookup?title=,+Autoimmune+post-COVID+vaccine+syndromes:+does+the+spectrum+of+autoimmune/inflammatory+syndrome+expand?&author=Jara,+L.+J.&author=Vera-Lastra,+O.&author=Mahroum,+N.&author=Pineda,+C.&author=Shoenfeld,+Y.&publication_year=2022&journal=Clinical+Rheumatology&volume=41&pages=1603%E2%80%9309&doi=10.1007/s10067-022-06149-4&pmid=35378658" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1007/s10067-022-06149-4" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/35378658" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B170-preprints-107672" class="html-xxx" data-content="170.">Kaulen, L. D.; Doubrovinskaia, S.; Mooshage, C.; Jordan, B.; Purrucker, J.; Haubner, C.; Seliger, C.; Lorenz, H. M.; Nagel, S.; Wildemann, B.; Bendszus, M.; Wick, W.; Schönenberger, S. , Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. <span class="html-italic">European Journal of Neurology</span> <b>2021</b>, <span class="html-italic">29</span>, 555–63. [<a href="https://scholar.google.com/scholar_lookup?title=,+Neurological+autoimmune+diseases+following+vaccinations+against+SARS-CoV-2:+a+case+series&author=Kaulen,+L.+D.&author=Doubrovinskaia,+S.&author=Mooshage,+C.&author=Jordan,+B.&author=Purrucker,+J.&author=Haubner,+C.&author=Seliger,+C.&author=Lorenz,+H.+M.&author=Nagel,+S.&author=Wildemann,+B.&publication_year=2021&journal=European+Journal+of+Neurology&volume=29&pages=555%E2%80%9363&doi=10.1111/ene.15147&pmid=34668274" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1111/ene.15147" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34668274" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B171-preprints-107672" class="html-xxx" data-content="171.">Agmon-Levin, N.; Damoiseaux, J.; Kallenberg, C.; Sack, U.; Witte, T.; Herold, M.; Bossuyt, X.; Musset, L.; Cervera, R.; Plaza-Lopez, A.; Dias, C.; Sousa, M. J.; Radice, A.; Eriksson, C.; Hultgren, O.; Viander, M.; Khamashta, M.; Regenass, S.; Andrade, L. E. C.; Wiik, A.; Tincani, A.; Rönnelid, J.; Bloch, D. B.; Fritzler, M. J.; Chan, E. K. L.; Garcia-De La Torre, I.; Konstantinov, K. N.; Lahita, R.; Wilson, M.; Vainio, O.; Fabien, N.; Sinico, R. A.; Meroni, P.; Shoenfeld, Y. , International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. <span class="html-italic">Annals of the Rheumatic Diseases</span> <b>2014</b>, <span class="html-italic">73</span>, 17–23. [<a href="https://scholar.google.com/scholar_lookup?title=,+International+recommendations+for+the+assessment+of+autoantibodies+to+cellular+antigens+referred+to+as+anti-nuclear+antibodies&author=Agmon-Levin,+N.&author=Damoiseaux,+J.&author=Kallenberg,+C.&author=Sack,+U.&author=Witte,+T.&author=Herold,+M.&author=Bossuyt,+X.&author=Musset,+L.&author=Cervera,+R.&author=Plaza-Lopez,+A.&publication_year=2014&journal=Annals+of+the+Rheumatic+Diseases&volume=73&pages=17%E2%80%9323&doi=10.1136/annrheumdis-2013-203863&pmid=24126457" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1136/annrheumdis-2013-203863" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/24126457" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B172-preprints-107672" class="html-xxx" data-content="172.">Xiao, Z. X.; Miller, J. S.; Zheng, S. G. , An updated advance of autoantibodies in autoimmune diseases. <span class="html-italic">Autoimmun Rev</span> <b>2021</b>, <span class="html-italic">20</span>, 102743. [<a href="https://scholar.google.com/scholar_lookup?title=,+An+updated+advance+of+autoantibodies+in+autoimmune+diseases&author=Xiao,+Z.+X.&author=Miller,+J.+S.&author=Zheng,+S.+G.&publication_year=2021&journal=Autoimmun+Rev&volume=20&pages=102743&doi=10.1016/j.autrev.2020.102743&pmid=33333232" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.autrev.2020.102743" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/33333232" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B173-preprints-107672" class="html-xxx" data-content="173.">Varghese, J. L.; Fung, A. W. S.; Mattman, A.; Quach, T. T. T.; Gauiran, D. T. V.; Carruthers, M. N.; Chen, L. Y. C. , Clinical utility of serum IgG4 measurement. <span class="html-italic">Clin Chim Acta</span> <b>2020</b>, <span class="html-italic">506</span>, 228–35. [<a href="https://scholar.google.com/scholar_lookup?title=,+Clinical+utility+of+serum+IgG4+measurement&author=Varghese,+J.+L.&author=Fung,+A.+W.+S.&author=Mattman,+A.&author=Quach,+T.+T.+T.&author=Gauiran,+D.+T.+V.&author=Carruthers,+M.+N.&author=Chen,+L.+Y.+C.&publication_year=2020&journal=Clin+Chim+Acta&volume=506&pages=228%E2%80%9335&doi=10.1016/j.cca.2020.04.001&pmid=32272158" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1016/j.cca.2020.04.001" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/32272158" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B174-preprints-107672" class="html-xxx" data-content="174.">Katz, G.; Stone, J. H. , Clinical Perspectives on IgG4-Related Disease and Its Classification. <span class="html-italic">Annu Rev Med</span> <b>2022</b>, <span class="html-italic">73</span>, 545–62. [<a href="https://scholar.google.com/scholar_lookup?title=,+Clinical+Perspectives+on+IgG4-Related+Disease+and+Its+Classification&author=Katz,+G.&author=Stone,+J.+H.&publication_year=2022&journal=Annu+Rev+Med&volume=73&pages=545%E2%80%9362&doi=10.1146/annurev-med-050219-034449&pmid=34669430" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1146/annurev-med-050219-034449" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34669430" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B175-preprints-107672" class="html-xxx" data-content="175.">Tsang, S.; Royse, C. F.; Terkawi, A. S. , Guidelines for developing, translating, and validating a questionnaire in perioperative and pain medicine. <span class="html-italic">Saudi J Anaesth</span> <b>2017</b>, <span class="html-italic">(Suppl 1)</span> (Suppl 1), S80–S89. [<a href="https://scholar.google.com/scholar_lookup?title=,+Guidelines+for+developing,+translating,+and+validating+a+questionnaire+in+perioperative+and+pain+medicine&author=Tsang,+S.&author=Royse,+C.+F.&author=Terkawi,+A.+S.&publication_year=2017&journal=Saudi+J+Anaesth&volume=(Suppl+1)&pages=S80%E2%80%93S89&doi=10.4103/sja.SJA_203_17" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.4103/sja.SJA_203_17" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B176-preprints-107672" class="html-xxx" data-content="176.">Semmler, A.; Mundorf, A. K.; Kuechler, A. S.; Schulze-Bosse, K.; Heidecke, H.; Schulze-Forster, K.; Schott, M.; Uhrberg, M.; Weinhold, S.; Lackner, K. J.; Pawlitzki, M.; Meuth, S. G.; Boege, F.; Ruhrländer, J. , Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers. <span class="html-italic">Vaccines</span> <b>2023</b>, 11. [<a href="https://scholar.google.com/scholar_lookup?title=,+Chronic+Fatigue+and+Dysautonomia+following+COVID-19+Vaccination+Is+Distinguished+from+Normal+Vaccination+Response+by+Altered+Blood+Markers&author=Semmler,+A.&author=Mundorf,+A.+K.&author=Kuechler,+A.+S.&author=Schulze-Bosse,+K.&author=Heidecke,+H.&author=Schulze-Forster,+K.&author=Schott,+M.&author=Uhrberg,+M.&author=Weinhold,+S.&author=Lackner,+K.+J.&publication_year=2023&journal=Vaccines&pages=11&doi=10.3390/vaccines11111642&pmid=38005974" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/vaccines11111642" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>] [<a href="https://www.ncbi.nlm.nih.gov/pubmed/38005974" class="cross-ref pub_med" data-typ="pmid" target="_blank" rel="noopener noreferrer">PubMed</a>]</li> <li id="B177-preprints-107672" class="html-xxx" data-content="177.">Islam, A.; Bashir, M. S.; Joyce, K.; Rashid, H.; Laher, I.; Elshazly, S. , An Update on COVID-19 Vaccine Induced Thrombotic Thrombocytopenia Syndrome and Some Management Recommendations. <span class="html-italic">Molecules</span> <b>2021</b>, 26. [<a href="https://scholar.google.com/scholar_lookup?title=,+An+Update+on+COVID-19+Vaccine+Induced+Thrombotic+Thrombocytopenia+Syndrome+and+Some+Management+Recommendations&author=Islam,+A.&author=Bashir,+M.+S.&author=Joyce,+K.&author=Rashid,+H.&author=Laher,+I.&author=Elshazly,+S.&publication_year=2021&journal=Molecules&pages=26&doi=10.3390/molecules26165004" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.3390/molecules26165004" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B178-preprints-107672" class="html-xxx" data-content="178.">Mevorach, D.; Anis, E.; Cedar, N.; Bromberg, M.; Haas, E. J.; Nadir, E.; Olsha-Castell, S.; Arad, D.; Hasin, T.; Levi, N.; Asleh, R.; Amir, O.; Meir, K.; Cohen, D.; Dichtiar, R.; Novick, D.; Hershkovitz, Y.; Dagan, R.; Leitersdorf, I.; Ben-Ami, R.; Miskin, I.; Saliba, W.; Muhsen, K.; Levi, Y.; Green, M. S.; Keinan-Boker, L.; Alroy-Preis, S. , Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel. <span class="html-italic">New England Journal of Medicine</span> <b>2021</b>, <span class="html-italic">385</span>, 2140–49. [<a href="https://scholar.google.com/scholar_lookup?title=,+Myocarditis+after+BNT162b2+mRNA+Vaccine+against+Covid-19+in+Israel&author=Mevorach,+D.&author=Anis,+E.&author=Cedar,+N.&author=Bromberg,+M.&author=Haas,+E.+J.&author=Nadir,+E.&author=Olsha-Castell,+S.&author=Arad,+D.&author=Hasin,+T.&author=Levi,+N.&publication_year=2021&journal=New+England+Journal+of+Medicine&volume=385&pages=2140%E2%80%9349&doi=10.1056/NEJMoa2109730" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1056/NEJMoa2109730" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> <li id="B179-preprints-107672" class="html-xxx" data-content="179.">Nakahara, T.; Iwabuchi, Y.; Miyazawa, R.; Tonda, K.; Shiga, T.; Strauss, H. W.; Antoniades, C.; Narula, J.; Jinzaki, M. , Assessment of Myocardial (18)F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2-vaccinated and Nonvaccinated Patients. <span class="html-italic">Radiology</span> <b>2023</b>, <span class="html-italic">308</span>, e230743. [<a href="https://scholar.google.com/scholar_lookup?title=,+Assessment+of+Myocardial+(18)F-FDG+Uptake+at+PET/CT+in+Asymptomatic+SARS-CoV-2-vaccinated+and+Nonvaccinated+Patients&author=Nakahara,+T.&author=Iwabuchi,+Y.&author=Miyazawa,+R.&author=Tonda,+K.&author=Shiga,+T.&author=Strauss,+H.+W.&author=Antoniades,+C.&author=Narula,+J.&author=Jinzaki,+M.&publication_year=2023&journal=Radiology&volume=308&pages=e230743&doi=10.1148/radiol.230743" class="google-scholar" target="_blank" rel="noopener noreferrer">Google Scholar</a>] [<a href="https://doi.org/10.1148/radiol.230743" class="cross-ref" target="_blank" rel="noopener noreferrer">CrossRef</a>]</li> </ol></section><section id="FiguresandTables" type="display-objects"><div class="html-fig-wrap" id="preprints-107672-f001"> <div class="html-fig_img"> <div class="html-figpopup html-figpopup-link" href="#fig_body_display_preprints-107672-f001"> <img data-large="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png" data-original="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png" alt="Preprints 107672 g001" src="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png"> <a class="html-expand html-figpopup" href="#fig_body_display_preprints-107672-f001"></a> </div> </div> <div class="html-fig_description"> <b>Figure 1.</b> <b>Possible mechanisms for spread of spike proteins and modified RNAs throughout the body.</b> Lipid nanoparticles (LNPs) are transported via the bloodstream to various tissues and organs. Cells that take up the LNPs are thought to produce spike proteins, and some of the spike proteins and modified RNA are released into the blood as exosomes. Exosomes containing spike proteins are transported to various tissues and organs via the bloodstream. LNPs are known to cause inflammation, and spike proteins are known to aggregate red blood cells and platelets, which may pose a risk of microthrombus formation. Note that LNPs and exosomes are drawn large in this figure for clarity.  </div> </div> <div class="html-fig_show mfp-hide" id="fig_body_display_preprints-107672-f001"> <div class="html-caption"> <b>Figure 1.</b> <b>Possible mechanisms for spread of spike proteins and modified RNAs throughout the body.</b> Lipid nanoparticles (LNPs) are transported via the bloodstream to various tissues and organs. Cells that take up the LNPs are thought to produce spike proteins, and some of the spike proteins and modified RNA are released into the blood as exosomes. Exosomes containing spike proteins are transported to various tissues and organs via the bloodstream. LNPs are known to cause inflammation, and spike proteins are known to aggregate red blood cells and platelets, which may pose a risk of microthrombus formation. Note that LNPs and exosomes are drawn large in this figure for clarity.</div> <div class="html-img"><img data-large="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png" data-original="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png" alt="Preprints 107672 g001" src="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png"></div> </div> <div class="html-fig-wrap" id="preprints-107672-f002"> <div class="html-fig_img"> <div class="html-figpopup html-figpopup-link" href="#fig_body_display_preprints-107672-f002"> <img data-large="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png" data-original="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png" alt="Preprints 107672 g002" src="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png"> <a class="html-expand html-figpopup" href="#fig_body_display_preprints-107672-f002"></a> </div> </div> <div class="html-fig_description"> <b>Figure 2.</b> <b>Proposed PVS risk management cycle.</b> Summary of items and procedures required for management of blood products derived from genetic vaccine recipients or those affected with spike protein and modified genes. As with any risk management exercise, it is important to constantly revise policies and procedures as risks and problems are identified. PVS, post-vaccination syndrome.  </div> </div> <div class="html-fig_show mfp-hide" id="fig_body_display_preprints-107672-f002"> <div class="html-caption"> <b>Figure 2.</b> <b>Proposed PVS risk management cycle.</b> Summary of items and procedures required for management of blood products derived from genetic vaccine recipients or those affected with spike protein and modified genes. As with any risk management exercise, it is important to constantly revise policies and procedures as risks and problems are identified. PVS, post-vaccination syndrome.</div> <div class="html-img"><img data-large="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png" data-original="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png" alt="Preprints 107672 g002" src="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png"></div> </div> <div class="html-fig-wrap" id="preprints-107672-f003"> <div class="html-fig_img"> <div class="html-figpopup html-figpopup-link" href="#fig_body_display_preprints-107672-f003"> <img data-large="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png" data-original="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png" alt="Preprints 107672 g003" src="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png"> <a class="html-expand html-figpopup" href="#fig_body_display_preprints-107672-f003"></a> </div> </div> <div class="html-fig_description"> <b>Figure 3.</b> <b>An example of a system for managing health injuries among genetic vaccine recipients.</b> Given the global nature of vaccination with genetic vaccines and the movement of vaccine recipients and blood products between countries, an international surveillance network to establish coordination among countries is needed. PVS, post-vaccination syndrome.  </div> </div> <div class="html-fig_show mfp-hide" id="fig_body_display_preprints-107672-f003"> <div class="html-caption"> <b>Figure 3.</b> <b>An example of a system for managing health injuries among genetic vaccine recipients.</b> Given the global nature of vaccination with genetic vaccines and the movement of vaccine recipients and blood products between countries, an international surveillance network to establish coordination among countries is needed. PVS, post-vaccination syndrome.</div> <div class="html-img"><img data-large="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png" data-original="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png" alt="Preprints 107672 g003" src="https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png"></div> </div> <div class="html-table-wrap" id="preprints-107672-t001"> <div class="html-table_wrap_td"> <div class="html-tablepopup html-tablepopup-link" href="#table_body_display_preprints-107672-t001"> <img src="https://pub.mdpi-res.com/img/table.png"> <a class="html-expand html-tablepopup" href="#table_body_display_preprints-107672-t001"></a> </div> </div> <div class="html-table_wrap_discription"> <b>Table 1.</b> Major concerns with the use of blood products derived from genetic vaccine recipients. </div> </div> <div class="html-table_show mfp-hide " id="table_body_display_preprints-107672-t001"> <div class="html-caption"> <b>Table 1.</b> Major concerns with the use of blood products derived from genetic vaccine recipients.</div> <table> <thead><tr> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center"> </th> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center">Concerns</th> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center">Description</th> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center">References</th> </tr></thead> <tbody> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">1</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Spike protein contamination</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">The spike protein, which is the antigen of SARS-CoV-2 and genetic vaccines, has already been found to have various toxicities, including effects on red blood cells and platelet aggregation, amyloid formation, and neurotoxicity. It is essential to recognize that the spike protein itself is toxic to humans. It has also been reported that the spike protein can cross the blood–brain barrier. Therefore, it is essential to remove the genetic vaccine-derived spike protein itself from blood products.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B22-preprints-107672" class="html-bibr">22</a>,<a href="#B29-preprints-107672" class="html-bibr">29</a>,<a href="#B45-preprints-107672" class="html-bibr">45</a>,<a href="#B56-preprints-107672" class="html-bibr">56</a>,<a href="#B57-preprints-107672" class="html-bibr">57</a>,<a href="#B58-preprints-107672" class="html-bibr">58</a>,<a href="#B59-preprints-107672" class="html-bibr">59</a>,<a href="#B60-preprints-107672" class="html-bibr">60</a>,<a href="#B61-preprints-107672" class="html-bibr">61</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">2</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Contamination with amyloid aggregates and microthrombi formed by spike proteins</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Amyloid aggregation and development of microthrombi formed by the spike proteins into visible thrombi is yet unknown. However, once formed, amyloid aggregates may not be readily cleared and therefore need to be removed from blood products. These amyloid aggregates have been shown to be toxic.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B52-preprints-107672" class="html-bibr">52</a>,<a href="#B53-preprints-107672" class="html-bibr">53</a>,<a href="#B131-preprints-107672" class="html-bibr">131</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">3</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Events attributable to decreased donor immune system and immune abnormalities due to immune imprinting or class switch to IgG4, etc., resulting from multiple doses of genetic vaccines</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">In cases where the immune function of a donor is impaired by vaccination with genetic vaccines, there is a risk that the donor might have an (subclinical) infectious disease or has developed viremia or other conditions after being infected with a pathogenic virus, even in the absence of subjective symptoms. Therefore, healthcare professionals who perform surgical procedures, including blood sampling and organ transplantation, as well as use blood products, should exercise caution while handling the blood of genetic vaccine recipients to prevent infections through blood. All healthcare professionals should be informed of these risks.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B64-preprints-107672" class="html-bibr">64</a>,<a href="#B65-preprints-107672" class="html-bibr">65</a>,<a href="#B66-preprints-107672" class="html-bibr">66</a>,<a href="#B67-preprints-107672" class="html-bibr">67</a>,<a href="#B68-preprints-107672" class="html-bibr">68</a>,<a href="#B71-preprints-107672" class="html-bibr">71</a>,<a href="#B72-preprints-107672" class="html-bibr">72</a>,<a href="#B73-preprints-107672" class="html-bibr">73</a>,<a href="#B74-preprints-107672" class="html-bibr">74</a>,<a href="#B75-preprints-107672" class="html-bibr">75</a>,<a href="#B76-preprints-107672" class="html-bibr">76</a>,<a href="#B81-preprints-107672" class="html-bibr">81</a>,<a href="#B82-preprints-107672" class="html-bibr">82</a>,<a href="#B83-preprints-107672" class="html-bibr">83</a>,<a href="#B84-preprints-107672" class="html-bibr">84</a>,<a href="#B85-preprints-107672" class="html-bibr">85</a>,<a href="#B87-preprints-107672" class="html-bibr">87</a>,<a href="#B88-preprints-107672" class="html-bibr">88</a>,<a href="#B89-preprints-107672" class="html-bibr">89</a>,<a href="#B90-preprints-107672" class="html-bibr">90</a>,<a href="#B91-preprints-107672" class="html-bibr">91</a>,<a href="#B92-preprints-107672" class="html-bibr">92</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">4</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Presence of lipid nanoparticles (LNPs) and pseudouridinated mRNA (mRNA vaccines only)</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">If the blood donated by recipients of mRNA vaccines is collected without a sufficient deferral period after genetic vaccination, LNPs and pseudouridinated mRNA may remain in the blood. LNPs are highly inflammatory and have been found to be thrombogenic, posing a risk to transfusion recipients. Furthermore, LNPs have potent adjuvant activity and pose a risk of inducing Adjuvant-Induced Autoimmune Syndrome (ASIA syndrome). An additional risk is that if the pseudouridinated mRNA is incorporated into the recipient's blood while still packaged in LNPs, further spike protein may be produced in the recipient's body. Additionally, if modified mRNAs persist in the body for a prolonged period of time, they can cause a decrease in immune functions.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B23-preprints-107672" class="html-bibr">23</a>,<a href="#B40-preprints-107672" class="html-bibr">40</a>,<a href="#B44-preprints-107672" class="html-bibr">44</a>,<a href="#B76-preprints-107672" class="html-bibr">76</a>,<a href="#B106-preprints-107672" class="html-bibr">106</a>,<a href="#B107-preprints-107672" class="html-bibr">107</a>,<a href="#B108-preprints-107672" class="html-bibr">108</a>,<a href="#B109-preprints-107672" class="html-bibr">109</a>,<a href="#B110-preprints-107672" class="html-bibr">110</a>,<a href="#B111-preprints-107672" class="html-bibr">111</a>,<a href="#B167-preprints-107672" class="html-bibr">167</a>,<a href="#B169-preprints-107672" class="html-bibr">169</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">5</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Contamination with aggregated red blood cells or platelets</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">The spike protein causes red blood cells and platelets to aggregate; these aggregates will be carried into the recipient's blood unless they are physically removed from the blood product before transfusion.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B7-preprints-107672" class="html-bibr">7</a>,<a href="#B8-preprints-107672" class="html-bibr">8</a>,<a href="#B9-preprints-107672" class="html-bibr">9</a>,<a href="#B10-preprints-107672" class="html-bibr">10</a>,<a href="#B11-preprints-107672" class="html-bibr">11</a>,<a href="#B50-preprints-107672" class="html-bibr">50</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">6</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Memory B cells producing IgG4 as well as IgG4 produced from them</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Large amounts (serum concentration typically above 1.25–1.4 g/L) of non-inflammatory IgG4-positive plasma cells can cause chronic inflammation, such as fibroinflammatory disease.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B78-preprints-107672" class="html-bibr">78</a>,<a href="#B79-preprints-107672" class="html-bibr">79</a>,<a href="#B80-preprints-107672" class="html-bibr">80</a>,<a href="#B173-preprints-107672" class="html-bibr">173</a>,<a href="#B174-preprints-107672" class="html-bibr">174</a>]</td> </tr> </tbody> </table> </div> <div class="html-table-wrap" id="preprints-107672-t002"> <div class="html-table_wrap_td"> <div class="html-tablepopup html-tablepopup-link" href="#table_body_display_preprints-107672-t002"> <img src="https://pub.mdpi-res.com/img/table.png"> <a class="html-expand html-tablepopup" href="#table_body_display_preprints-107672-t002"></a> </div> </div> <div class="html-table_wrap_discription"> <b>Table 2.</b> Tests needed to confirm the safety of blood products. </div> </div> <div class="html-table_show mfp-hide " id="table_body_display_preprints-107672-t002"> <div class="html-caption"> <b>Table 2.</b> Tests needed to confirm the safety of blood products.</div> <table> <thead><tr> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center"> </th> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center">Concerns</th> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center">Description</th> <th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" class="html-align-center">References</th> </tr></thead> <tbody> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">1</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Spike protein content in blood</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Immunochemical techniques include enzyme-linked immunosorbent assay, immunophenotyping, mass spectrometry, liquid biopsy, and a combination of liquid biopsy and proteomics. We propose initially conducting mass spectrometry because it can directly measure the protein itself.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B28-preprints-107672" class="html-bibr">28</a>,<a href="#B29-preprints-107672" class="html-bibr">29</a>,<a href="#B124-preprints-107672" class="html-bibr">124</a>,<a href="#B125-preprints-107672" class="html-bibr">125</a>,<a href="#B126-preprints-107672" class="html-bibr">126</a>,<a href="#B127-preprints-107672" class="html-bibr">127</a>,<a href="#B129-preprints-107672" class="html-bibr">129</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">2</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Spike protein mRNA in blood</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">PCR and/or liquid biopsy are the options. If mRNA for the spike protein is detected, lipid nanoparticles (LNPs) may be present (mRNA vaccines only).</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B127-preprints-107672" class="html-bibr">127</a>,<a href="#B128-preprints-107672" class="html-bibr">128</a>,<a href="#B130-preprints-107672" class="html-bibr">130</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">3</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Spike protein DNA in blood</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">PCR and liquid biopsy are the options. This test is necessary because AstraZeneca's viral vector is a DNA vaccine. For mRNA vaccines, it is believed that pseudouridinated mRNA is not reverse transcribed, but this test is required if the spike protein remains in the body for a prolonged period.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B127-preprints-107672" class="html-bibr">127</a>,<a href="#B128-preprints-107672" class="html-bibr">128</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">4</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Autoimmune disorders</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Long-term persistence of the spike protein in the blood increases the risk of autoimmune disease. Therefore, it would be useful to assess for autoimmune disease using antinuclear antibodies as biomarkers in people who are positive for the spike protein, taking into account the results of interviews regarding the subjective symptoms.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B27-preprints-107672" class="html-bibr">27</a>,<a href="#B169-preprints-107672" class="html-bibr">169</a>,<a href="#B171-preprints-107672" class="html-bibr">171</a>,<a href="#B172-preprints-107672" class="html-bibr">172</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">5</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Post-vaccination syndrome (PVS)</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">A history of vaccination with genetic vaccines and COVID-19, current and previous medical history, and presence of subjective symptoms (e.g., headache, chest pain, shortness of breath, malaise) should be obtained from blood donors and formally recorded. The type of questions included in the interview are critical to facilitate diagnosis and treatment of COVID-19 PVS, as more people are complaining of psychiatric and neurological symptoms after genetic vaccination.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B15-preprints-107672" class="html-bibr">15</a>,<a href="#B175-preprints-107672" class="html-bibr">175</a>,<a href="#B176-preprints-107672" class="html-bibr">176</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">6</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Proteins resulting from frameshifting of pseudouridinated mRNA</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Although it is not yet clear whether proteins other than the spike protein are translated from pseudouridinated mRNAs, mass spectrometry may be useful in confirming this.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B166-preprints-107672" class="html-bibr">166</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">7</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Amyloid aggregates and thrombi</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Common markers of thrombosis, such as D-dimer, should be first used. Once the major components of amyloid aggregates and thrombi have been identified, their use as biomarkers is proposed. Understanding the composition of amyloid aggregates will be important in the future, as amyloid aggregates have been reported to be toxic. Understanding the composition of amyloid aggregates may provide clues to how amyloid is broken down.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B52-preprints-107672" class="html-bibr">52</a>,<a href="#B53-preprints-107672" class="html-bibr">53</a>,<a href="#B131-preprints-107672" class="html-bibr">131</a>,<a href="#B177-preprints-107672" class="html-bibr">177</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">8</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Origin of spike protein</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">This test will help determine whether the spike protein is from the genetic vaccine or from SARS-CoV-2. Potential candidates include nucleocapsid.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B4-preprints-107672" class="html-bibr">4</a>,<a href="#B5-preprints-107672" class="html-bibr">5</a>,<a href="#B41-preprints-107672" class="html-bibr">41</a>,<a href="#B128-preprints-107672" class="html-bibr">128</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">9</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Immunosuppression</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">It may be necessary to analyze immunoglobulin subclasses (such as the amount of IgG4) if immunosuppression from multiple doses of the genetic vaccine is a concern.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B71-preprints-107672" class="html-bibr">71</a>,<a href="#B72-preprints-107672" class="html-bibr">72</a>,<a href="#B73-preprints-107672" class="html-bibr">73</a>,<a href="#B74-preprints-107672" class="html-bibr">74</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">10</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Anti-nucleocapsid antibodies</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">The presence or absence and amount of anti-nucleocapsid antibodies as well as antibody isotypes may be an indicator(s) for distinguishing whether these are caused by genetic vaccines or long COVID.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B141-preprints-107672" class="html-bibr">141</a>,<a href="#B142-preprints-107672" class="html-bibr">142</a>,<a href="#B143-preprints-107672" class="html-bibr">143</a>]</td> </tr> <tr> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">11</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Others</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">Occurrence of myocarditis and pericarditis after genetic vaccination has been reported in various countries. Therefore, those with subjective symptoms should also be assessed for myocarditis markers, such as cardiac troponin T.</td> <td align="center" valign="middle" style="border-bottom:solid thin" class="html-align-center">[<a href="#B18-preprints-107672" class="html-bibr">18</a>,<a href="#B19-preprints-107672" class="html-bibr">19</a>,<a href="#B29-preprints-107672" class="html-bibr">29</a>,<a href="#B144-preprints-107672" class="html-bibr">144</a>,<a href="#B178-preprints-107672" class="html-bibr">178</a>,<a href="#B179-preprints-107672" class="html-bibr">179</a>]</td> </tr> </tbody> </table> </div> </section><section class="html-fn_group"><table><tr id> <td></td> <td><div class="html-p"> <b>Disclaimer/Publisher’s Note:</b> The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.</div></td> </tr></table></section> <section id="html-copyright"><br>© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a>).</section> </div><div class="pt-lg" data-v-da90062a><span class="m-text text-body font-semibold" data-v-da90062a>Copyright: </span><span class="m-text text-body" data-v-da90062a>This open access article is published under a <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" data-v-da90062a><span class="hover:underline cursor-pointer text-color-link-bold" data-v-da90062a>Creative Commons CC BY 4.0 license</span></a>, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.</span></div></div><div class="pt-md"><div class="swiper"><div class="swiper-wrapper"><div class="swiper-slide" data-swiper-slide-index="0"><a href="https://www.mdpi.com/authors/english?utm_source=preprintsweb&utm_medium=banner&utm_campaign=AS_High-quality" target="_blank"><img src="https://www.preprints.org/media/cache/resolve/webp/upload/banner/2024-10-30/c8ecd3b8b0ebf1abcd96d37f5ee4a609.jpeg" class="w-full h-auto"></a></div><div class="swiper-slide" data-swiper-slide-index="1"><a href="https://www.preprints.org/activity/award/announcement?utm_source=ArticlePage&utm_medium=Banner&utm_campaign=award" target="_blank"><img src="https://www.preprints.org/media/cache/resolve/webp/upload/banner/2024-10-30/58bbc3b8f7c90f2eab7ce32d00691421.jpeg" class="w-full h-auto"></a></div></div><div class="swiper-pagination"></div></div></div><div class="pt-md lg:pt-lg" data-v-694159ae><div class="m-accordion mx-auto flex w-full flex-col gap-3 rounded-2xl bg-white" data-v-694159ae><div class="m-accordion__item border-b border-color-default" data-v-694159ae><button id="accordion-button-expand-0" aria-controls="accordion-panel-0" class="relative mb-xs flex w-full cursor-pointer py-md text-sm outline-offset-2" aria-expanded="true"><span class="text-sm">Recommended Articles</span><div class="absolute right-0 top-1/2 -translate-y-1/2"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="keyboard_arrow_down" class="origin-center transition duration-150 rotate-180" style="" width="16" height="16" viewBox="0 0 16 16"></svg></div></button><div id="accordion-panel-0" aria-labelledby="accordion-button-expand-0" role="region" class="m-accordion__body overflow-hidden transition-height duration-150"><div class="break-words pb-md"><div class="w-full" data-v-694159ae><div class="mb-md"><a href="https://doi.org/10.20944/preprints202404.1703.v1" target="_blank"><div class="m-rich-text text-body font-semibold">Risk of Blood Clots After COVID-19 Vaccination and Infection: A Risk-Benefit Analysis</div></a><div class="pt-xs flex"><div class="flex items-center pr-sm flex-wrap"><p class="m-text text-sm">Huong NQ Tran</p><p class="m-text text-xs pl-xs">et al.</p><p class="m-text text-xs pl-xs italic">,</p><p class="m-text text-sm ml-xs font-semibold">2024</p></div></div></div><div class="mb-md"><a href="https://doi.org/10.20944/preprints202110.0404.v1" target="_blank"><div class="m-rich-text text-body font-semibold">The 4-Year Experience with Implementation and Routine Use of Pathogen Inactivation in a Brazilian Hospital</div></a><div class="pt-xs flex"><div class="flex items-center pr-sm flex-wrap"><p class="m-text text-sm">Roberta Maria Fachini</p><p class="m-text text-xs pl-xs">et al.</p><p class="m-text text-xs pl-xs italic">,</p><p class="m-text text-sm ml-xs font-semibold">2021</p></div></div></div><div class="mb-md"><a href="https://doi.org/10.20944/preprints202206.0080.v1" target="_blank"><div class="m-rich-text text-body font-semibold">The Frequency and Patterns of Post-COVID-19 Vaccination Syndrome Reveal Initially Mild and Potentially Immunocytopenic Signs in Primarily Young Saudi Women</div></a><div class="pt-xs flex"><div class="flex items-center pr-sm flex-wrap"><p class="m-text text-sm">Kamaleldin B. Said</p><p class="m-text text-xs pl-xs">et al.</p><p class="m-text text-xs pl-xs italic">,</p><p class="m-text text-sm ml-xs font-semibold">2022</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div><span></span></div><div class="border-t-[.0625rem] border-solid border-color-default"><div class="m-container mx-auto w-full flex-col-reverse py-section-mobile py-2xl lg:py-10xl bg-white" style="--container-ideal-width:92.5vw;"><div class="h-[auto]"><div class="flex flex-wrap"><div class="w-[100%] lg:w-[25%] xl:w-[25%] lg:px-[.9375rem] pb-lg"><div class="w-36 h-auto mb-lg cursor-pointer"><a href="/"><img src="/_nuxt/preprints.C_f_-Qxj.png" alt="Prerpints.org logo" class="w-36 h-auto"></a></div><p class="m-text text-sm mb-lg">Preprints.org is a free preprint server supported by MDPI in Basel, Switzerland.</p><div class="flex lg:items-center lg:block pb-0 items-start justify-between"><div class="flex lg:mb-lg"><a href="https://www.facebook.com/MDPIOpenAccessPublishing" target="_blank" rel="noopener noreferrer"><img src="/img/footerImg/facebook.svg" alt="facebook logo" class="w-6 h-6 mr-md"></a><a href="https://twitter.com/Preprints_org" target="_blank" rel="noopener noreferrer"><img src="/img/footerImg/twitter.svg" alt="twitter logo" class="w-6 h-6 mr-md"></a><a href="https://www.linkedin.com/showcase/preprints" target="_blank" rel="noopener noreferrer"><img src="/img/footerImg/linkedin.svg" alt="linkedin logo" class="w-6 h-6 mr-md"></a><div class="w-40"><div class="relative" data-headlessui-state><button id="headlessui-popover-button-mui-2285" type="button" aria-expanded="false" data-headlessui-state><img src="data:image/svg+xml,%3csvg%20width='22'%20height='19'%20viewBox='0%200%2022%2019'%20fill='none'%20xmlns='http://www.w3.org/2000/svg'%3e%3cg%20id='Group'%3e%3cpath%20id='Vector'%20d='M15.0641%206.7834C13.1271%206.8846%2011.4427%207.4718%2010.0751%208.79844C8.69347%2010.1388%208.06283%2011.7812%208.23515%2013.8172C7.47803%2013.7234%206.78843%2013.6202%206.09491%2013.5618C5.85539%2013.5416%205.57115%2013.5703%205.36827%2013.6848C4.69483%2014.0648%204.04931%2014.4938%203.28403%2014.9722C3.42443%2014.3372%203.51531%2013.781%203.67619%2013.2462C3.79451%2012.8531%203.73971%2012.6344%203.37755%2012.3782C1.05227%2010.7365%200.0721108%208.27972%200.805631%205.7502C1.48427%203.4102%203.15083%201.99108%205.41531%201.25132C8.50619%200.241717%2011.9797%201.27156%2013.8591%203.72548C14.5379%204.61188%2014.9541%205.60676%2015.0641%206.7834ZM6.14915%205.99524C6.16699%205.5326%205.76611%205.1158%205.28995%205.10188C4.80243%205.08756%204.40147%205.46012%204.38723%205.94052C4.37283%206.4274%204.74523%206.81756%205.23627%206.83004C5.72307%206.84236%206.13115%206.46932%206.14915%205.99524ZM10.8004%205.10156C10.3225%205.11036%209.91867%205.5174%209.92715%205.98188C9.93587%206.46332%2010.332%206.83996%2010.8235%206.83404C11.3162%206.82812%2011.6899%206.44748%2011.6852%205.95588C11.6811%205.47332%2011.2868%205.09268%2010.8004%205.10156Z'%20fill='white'/%3e%3cpath%20id='Vector_2'%20d='M19.4168%2018.8594C18.8034%2018.5863%2018.2408%2018.1765%2017.6417%2018.114C17.045%2018.0516%2016.4177%2018.3959%2015.7934%2018.4597C13.8917%2018.6543%2012.188%2018.1243%2010.7832%2016.8252C8.11148%2014.3539%208.49324%2010.5648%2011.5844%208.53972C14.3316%206.73988%2018.3607%207.33988%2020.2976%209.83724C21.988%2012.0164%2021.7893%2014.9092%2019.7258%2016.74C19.1287%2017.2698%2018.9139%2017.7058%2019.297%2018.4043C19.3676%2018.5332%2019.3757%2018.6965%2019.4168%2018.8594ZM12.4348%2012.0995C12.8253%2012.0999%2013.1468%2011.7943%2013.1616%2011.4086C13.1772%2011.0003%2012.8488%2010.6578%2012.44%2010.6561C12.0351%2010.6543%2011.696%2011.0016%2011.7101%2011.4038C11.7234%2011.7881%2012.0472%2012.099%2012.4348%2012.0995ZM16.9357%2010.6577C16.5569%2010.6551%2016.2349%2010.9652%2016.2195%2011.348C16.2031%2011.7574%2016.5212%2012.0936%2016.9264%2012.0946C17.3182%2012.096%2017.6279%2011.7996%2017.642%2011.4096C17.6572%2010.9993%2017.3389%2010.6605%2016.9357%2010.6577Z'%20fill='white'/%3e%3c/g%3e%3c/svg%3e" class="w-6 h-6 bg-black rounded cursor-pointer" alt="weChat logo"></button></div><div hidden style="position:fixed;top:1;left:1;width:1;height:0;padding:0;margin:-1;overflow:hidden;clip:rect(0, 0, 0, 0);white-space:nowrap;border-width:0;display:none;"></div></div></div><div class="flex items-center flex-col w-min lg:gap-y-lg gap-y-md"><a class="inline-block" href="mailto:info@preprints.org"><button class="m-button m-button--md m-button--secondary rounded" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center">Contact Us</span></button></a><button class="m-button m-button--md m-button--secondary rounded !w-full" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="rss_feed" weight="400" style="" width="16" height="16" viewBox="0 0 16 16"></svg>RSS</span></button></div></div></div><div class="w-[100%] lg:w-[25%] xl:w-[25%] px-md pt-sm border-t border-color-black sm:pt-0 sm:border-0 sm:border-white"><div class="flex items-center justify-between lg:block"><h5 class="m-heading text-inherit m-h5 font-semibold pt-md lg:pt-0 pb-lg"> MDPI Initiatives </h5><div class="block lg:hidden"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="expand_more" weight="400" style="" width="24" height="24" viewBox="0 0 16 16"></svg></div></div><ul class="hidden lg:block"><li class="pb-lg"><a target="_blank" href="https://sciprofiles.com/" class="flex items-center"><p class="m-text text-sm">SciProfiles</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li><li class="pb-lg"><a target="_blank" href="https://sciforum.net/" class="flex items-center"><p class="m-text text-sm">Sciforum</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li><li class="pb-lg"><a target="_blank" href="https://encyclopedia.pub/" class="flex items-center"><p class="m-text text-sm">Encyclopedia</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li><li class="pb-lg"><a target="_blank" href="https://www.mdpi.com/books" class="flex items-center"><p class="m-text text-sm">MDPI Books</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li><li class="pb-lg"><a target="_blank" href="https://www.scilit.net/" class="flex items-center"><p class="m-text text-sm">Scilit</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li><li class="pb-lg"><a target="_blank" href="https://www.mdpi.com/about/proceedings" class="flex items-center"><p class="m-text text-sm">Proceedings</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li><li class="pb-lg"><a target="_blank" href="https://jams.pub/" class="flex items-center"><p class="m-text text-sm">JAMS</p><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="open_in_new" class="align-middle ml-xs" style="" width="16" height="16" viewBox="0 0 16 16"></svg></a></li></ul></div><div class="w-[100%] lg:w-[25%] xl:w-[25%] px-[.9375rem] pt-[.625rem] border-t border-[#000] sm:pt-[.625rem] sm:border-t sm:border-[#000] lg:pt-0 lg:border-0 lg:border-white"><div class="flex items-center justify-between lg:block"><h5 class="m-heading text-inherit m-h5 font-semibold pt-md lg:pt-0 pb-lg"> Important Links </h5><div class="block lg:hidden"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="expand_more" weight="400" class="block lg:hidden" style="" width="24" height="24" viewBox="0 0 16 16"></svg></div></div><ul class="cursor-pointer hidden lg:block"><li class="pb-lg"><a href="/advisory-board" class=""><p class="m-text text-sm">Advisory Board</p></a></li><li class="pb-lg"><a href="/activity/award/announcement" class=""><p class="m-text text-sm">Award</p></a></li><li class="pb-lg"><a href="/collection" class=""><p class="m-text text-sm">Collections</p></a></li><li class="pb-lg"><a href="/friendly-journals" class=""><p class="m-text text-sm">Friendly Journals</p></a></li><li class="pb-lg"><a href="/about?scrollTo=works" class=""><p class="m-text text-sm">How It Works</p></a></li><li class="pb-lg"><a href="/topics" class=""><p class="m-text text-sm">MDPI Topics</p></a></li><li class="pb-lg"><a href="/statistics" class=""><p class="m-text text-sm">Statistics</p></a></li></ul></div><div class="w-[100%] lg:w-[25%] xl:w-[25%] px-[.9375rem] pt-[.625rem] border-t border-[#000] sm:pt-[.625rem] sm:border-t sm:border-[#000] lg:pt-0 lg:border-0 lg:border-white"><div class="flex items-center justify-between lg:block"><h5 class="m-heading text-inherit m-h5 font-semibold pt-md lg:pt-0 pb-lg"> Subscribe </h5><div class="block lg:hidden"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" aria-hidden="true" role="img" data-testid="expand_more" weight="400" class="block lg:hidden" style="" width="24" height="24" viewBox="0 0 16 16"></svg></div></div><div class="hidden lg:block"><div class="pb-lg"><p class="m-text text-sm">Choose an area of interest and we will send you notifications of new preprints at your preferred frequency.</p></div><a href="/user/notification/settings?scrollTo=subscribe" class=""><button class="m-button m-button--md m-button--tonal rounded !text-color-white !bg-black mr-5" type="button"><span class="inline-flex h-full w-full items-center gap-2 whitespace-nowrap justify-center">Subscribe</span></button></a></div></div></div></div></div><div class="bg-black"><div class="m-container mx-auto w-full flex-col-reverse py-section-mobile" style="--container-ideal-width:92.5vw;"><div class="text-color-white"><div class="flex justify-between items-center flex-wrap cursor-pointer"><p class="m-text text-sm py-lg hidden lg:block">© 2024 MDPI (Basel, Switzerland) unless otherwise stated</p><div class="lg:flex items-center py-xl"><div class="flex items-center pr-xl pb-md lg:pb-0"><p class="m-text text-sm pr-xs">Disclaimer</p><span></span></div><p class="m-text text-sm pr-xl pb-md lg:pb-0"><a href="/terms-of-use?scrollTo=term-use" class="">Terms of Use</a></p><p class="m-text text-sm"><a href="/terms-of-use?scrollTo=privacy-policy" class="">Privacy Policy</a></p></div><p class="m-text text-sm py-lg block lg:hidden">© 2024 MDPI (Basel, Switzerland) unless otherwise stated</p></div></div></div></div></div></div></div><div id="teleports"></div><script type="application/json" id="__NUXT_DATA__" data-ssr="true">[["ShallowReactive",1],{"data":2,"state":500,"once":509,"_errors":510,"serverRendered":6,"path":512,"pinia":513},["ShallowReactive",3],{"blog-config":4,"strapi-config":39,"mgOlEjP40X":40,"Ya7hZzqdE7":45,"PlVuOumUsI":123,"JoG0wWOyMK":210,"V2IvscPMVh":221,"6gTy2KwK9d":224},{"postsPerPage":5,"isInfinite":6,"cacheTime":7,"categories":8},9,true,1,[9,14,19,24,29,34],{"id":10,"title":11,"cacheKey":12,"href":13},288,"Learn about Preprints","288-posts","/blog/category/learn-about-preprints",{"id":15,"title":16,"cacheKey":17,"href":18},1383,"Platform Features","1383-posts","/blog/category/platform-features",{"id":20,"title":21,"cacheKey":22,"href":23},22,"Community Content","22-posts","/blog/category/community-content",{"id":25,"title":26,"cacheKey":27,"href":28},1351,"Featured Preprints","1351-posts","/blog/category/featured-preprints",{"id":30,"title":31,"cacheKey":32,"href":33},1380,"Preprints and Society","1380-posts","/blog/category/preprints-and-society",{"id":35,"title":36,"cacheKey":37,"href":38},1381,"News and Announcements","1381-posts","/blog/category/news-and-announcements",{"cacheTime":7},{"code":41,"msg":42,"data":43},0,"success",{"url":44},"https://www.preprints.org/rss",{"code":41,"msg":42,"data":46},[47,54,61,68,75,82,88,95,102,109,116],{"id":7,"name":48,"name_system":49,"parent_id":50,"image_banner":51,"description":52,"converted_name_system":53},"Arts and Humanities","arts_and_humanities",null,"https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/bb621e164c1f8a2a8bfd78d6ac510e15.jpg","Immerse yourself in a world of creativity and critical thinking with our preprints in arts and humanities. Uncover the depths of human expression, history, and thought across disciplines like archaeology, literature, and philosophy. Explore diverse perspectives that enrich our understanding of cultural heritage and the human experience.","arts-and-humanities",{"id":55,"name":56,"name_system":57,"parent_id":50,"image_banner":58,"description":59,"converted_name_system":60},16,"Biology and Life Sciences","biology_and_life_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/8d795777f5834c04ac4b98f9c94c4c6b.jpg","Journey into the intricate world of living organisms with our preprints. From molecular mechanisms to ecosystem interactions, discover the wonders of life and the natural world through cutting-edge research. Dive into the forefront of biological discovery and explore the complexities of our living world.","biology-and-life-sciences",{"id":62,"name":63,"name_system":64,"parent_id":50,"image_banner":65,"description":66,"converted_name_system":67},41,"Business, Economics and Management","business_economics_and_management","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/ab197ef385773a30f4650e40ae8f03d5.jpg","Explore the dynamic world of business operations, economic theories, and organizational leadership with our preprints. Uncover insights in business, economics, and management that shape global commerce and innovation. Stay informed on the latest trends and research driving the landscape of business and economics.","business-economics-and-management",{"id":69,"name":70,"name_system":71,"parent_id":50,"image_banner":72,"description":73,"converted_name_system":74},50,"Chemistry and Materials Science","chemistry_and_materials_science","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/cc2a7d5d84540df918315b4feb38028a.jpg","Unravel the mysteries of matter and its transformations with our preprints. From atomic structures to novel material synthesis, stay informed on the latest research in this fascinating field. Explore the diverse properties and applications of chemistry and materials science that shape our world.","chemistry-and-materials-science",{"id":76,"name":77,"name_system":78,"parent_id":50,"image_banner":79,"description":80,"converted_name_system":81},71,"Computer Science and Mathematics","computer_science_and_mathematics","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/5b0a41a25a67d1112cb8833b497bf7be.jpg","Embark on a journey through the foundational principles of algorithms, artificial intelligence, and mathematical theories with our preprints. Explore cutting-edge research in computational mathematics and data analysis that drives innovation in the digital age. Dive into a world of innovation and discovery in this exciting field.","computer-science-and-mathematics",{"id":83,"name":84,"name_system":85,"parent_id":50,"image_banner":86,"description":87,"converted_name_system":85},94,"Engineering","engineering","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/908d2aac5be9f3be128d20cc98154c17.jpg","Explore the diverse realms of engineering with our preprints, where innovation meets expertise across various disciplines. From industrial processes to energy technologies, delve into the forefront of engineering advancements. Stay updated on the latest research shaping the dynamic and ever-evolving field of engineering.",{"id":89,"name":90,"name_system":91,"parent_id":50,"image_banner":92,"description":93,"converted_name_system":94},113,"Environmental and Earth Sciences","environmental_and_earth_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/427574c3272a512b9412d12b3bfb3f51.jpg","Investigate the dynamic processes shaping our planet with our preprints. From atmospheric phenomena to oceanography, explore the interconnected systems of our planet and the innovative solutions shaping its future. Stay informed on research that impacts our environment and sustainability.","environmental-and-earth-sciences",{"id":96,"name":97,"name_system":98,"parent_id":50,"image_banner":99,"description":100,"converted_name_system":101},130,"Medicine and Pharmacology","medicine_and_pharmacology","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/98c86d1fdf40abfda51ca959f75f3499.jpg","Embark on a journey through the vast world of medicine and pharmacology with our preprints. Explore breakthroughs in healthcare, from cardiology to neurology, which improve human health outcomes. Delve into the frontiers of medical research and pharmaceutical development that enhance quality of life.","medicine-and-pharmacology",{"id":103,"name":104,"name_system":105,"parent_id":50,"image_banner":106,"description":107,"converted_name_system":108},166,"Physical Sciences","physical_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/c2d6e400b105b8c3d32ec59f26ab969d.jpg","Explore the fundamental laws governing matter and energy in the universe with our preprints. From quantum mechanics to cosmology, stay abreast of research that advances our understanding of the natural world. Dive into a world of scientific discovery that pushes the boundaries of knowledge.","physical-sciences",{"id":110,"name":111,"name_system":112,"parent_id":50,"image_banner":113,"description":114,"converted_name_system":115},185,"Public Health and Healthcare","public_health_and_healthcare","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-11-07/ef7c6de55fa117659c3b6090edc7c4ff.jpg","Examine critical issues in public health policy, epidemiology, and healthcare systems with our preprints. Stay updated on research into health disparities, infectious disease control, and healthcare management, which informs public health interventions. Explore the latest trends in healthcare that impact population well-being and equity.","public-health-and-healthcare",{"id":117,"name":118,"name_system":119,"parent_id":50,"image_banner":120,"description":121,"converted_name_system":122},193,"Social Sciences","social_sciences","https://www.preprints.org/media/cache/resolve/webp/upload/subject/2024-09-12/910c960e3a6808861523728f0f26b2df.png","Gain insights into human behavior, societies, and cultures with our preprints. Explore disciplines like psychology, sociology, and political science, which shape our world and inform public policy. Stay engaged with research that explores social issues, cultural dynamics, and economic systems, enriching our understanding of human interactions.","social-sciences",{"code":41,"msg":42,"data":124},{"temp_id":125,"version":126,"id":127,"hash_key":128,"doi":129,"article_abstract":130,"article_title":131,"keywords":132,"is_registering_doi":133,"mdpi_topic":50,"preprints_collections":134,"subject":138,"top_subject":141,"article_type":142,"submitted_at":144,"published_at":145,"last_edited_at":50,"authors":146,"ethical_approval":133,"ethical_approval_number":50,"ethical_approval_body":50,"ethical_approval_for_publication":133,"article_supplementary":50,"final_file":188,"graphic_abstract":192,"statistics":193,"is_peer_reviewed":133,"peer_reviewed_article_url":50,"almetric":196,"preserved_by_portico":6,"ms_xml":199,"versions":201,"citation":206,"peer_reviewed_citation":50,"version_changes":207,"updating_alert_registered":133,"preprints_process_url":50,"comments_count":41,"latest_version":126,"author_notes":209,"withdrawed_at":50,"is_withdrwan":133},107672,2,"202403.0881","37da1875eaf1141b1336b5d3126236b4","10.20944/preprints202403.0881.v2","\u003Cp>The World Health Organization declared the coronavirus disease 2019 (COVID-19) pandemic in 2020, following which a global genetic vaccination program has been rapidly implemented as a fundamental solution. However, it has been reported worldwide that the modified mRNAs encoding spike proteins and lipid nanoparticles, which are used as drug delivery systems, not only cause thrombosis and cardiovascular disorders post vaccination, but might also cause diverse diseases involving all organs and systems, including the nervous system. Furthermore, the toxicity and pathogenicity of spike proteins may necessitate defining these proteins as nonbiological infective material. Based on these reports and the abundant evidence that has come to light in the past few years, this paper aims to draw the attention of medical professionals to the various risks associated with transfusion using blood products derived from long COVID patients or from genetic vaccine recipients, and to make proposals regarding specific inspection items, testing methods, regulations, etc. This paper provides insights to address the post-vaccination syndrome and its consequences following such genetic vaccination programs.\u003C/p>","Transfusions of Blood Products Derived from Genetic Vaccine Recipients: Safety Concerns and Proposals for Specific Measures","COVID-19 vaccine; genetic vaccine; blood product; blood transfusion; spike protein; post-vaccination syndrome; harm–benefit assessment; prion; spikeopathy; inspection standard; diagnostic criteria ",false,[135],{"title":136,"id":7,"name_system":137},"Preprints on COVID-19 and SARS-CoV-2","covid19",{"id":139,"name":140},162,"Transplantation",{"id":96,"name":97},{"id":55,"name":143},"Review","2024-05-28 10:38:46","2024-05-29 08:33:19",[147,155,161,166,172,177,182],{"id":148,"name":149,"email":150,"is_corresponding":6,"orcid_link":151,"author_mark":152,"sp_link":153,"avatar":154},507312,"Jun Ueda","junueda@asahikawa-med.ac.jp","https://orcid.org/0000-0002-9766-203X","*","https://sciprofiles.com/profile/909446","/statics/img/design/default-user.png",{"id":156,"name":157,"email":158,"is_corresponding":133,"orcid_link":50,"author_mark":159,"sp_link":160,"avatar":50},507313,"Hideyuki Motohashi","moto@tokyo-med.ac.jp","","https://sciprofiles.com/profile/author/NmJydjdvK2cxZUhIeDlBaElhb1Nqdkd5L1Z6SEtoNmxhczNjd0g0Q016cz0=",{"id":162,"name":163,"email":164,"is_corresponding":133,"orcid_link":50,"author_mark":159,"sp_link":165,"avatar":50},507314,"Yuriko Hirai","hirai@mcl-corp.jp","https://sciprofiles.com/profile/author/K2VwKzNxaGhmRnRPazJVTVdVQ05SYmpQU1JsVzk5UkhPNjJweWZicG9HZz0=",{"id":167,"name":168,"email":169,"is_corresponding":133,"orcid_link":170,"author_mark":159,"sp_link":171,"avatar":154},507315,"Kenji Yamamoto","yamamoto@okamura.or.jp","https://orcid.org/0000-0003-4482-5816","https://sciprofiles.com/profile/3457934",{"id":173,"name":174,"email":175,"is_corresponding":133,"orcid_link":50,"author_mark":159,"sp_link":176,"avatar":154},507316,"Yasufumi Murakami","yasufumi@rs.tus.ac.jp","https://sciprofiles.com/profile/1272428",{"id":178,"name":179,"email":180,"is_corresponding":133,"orcid_link":50,"author_mark":159,"sp_link":181,"avatar":50},507317,"Masanori Fukushima","mfukushima@imrd.jp","https://sciprofiles.com/profile/author/ZE9Pai9sV2tiN1l5YzB2NmpvZm5EeHdiTHRlQjY5TjN1TEc3OUdtWWljRT0=",{"id":183,"name":184,"email":185,"is_corresponding":6,"orcid_link":186,"author_mark":152,"sp_link":187,"avatar":154},507318,"Akinori Fujisawa","fujisawa.peace@mac.com","https://orcid.org/0009-0009-0483-505X","https://sciprofiles.com/profile/3438232",{"filename":189,"url":190,"filesize":191},"final_file.pdf","/frontend/manuscript/37da1875eaf1141b1336b5d3126236b4/download_pub",1555193,[],{"viewed":194,"downloaded":195},"87271","19080",{"score":197,"detail_url":198},352,"https://preprints.altmetric.com/details/doi/10.20944/preprints202403.0881.v2",{"html_content":200},"\u003Cscript type=\"text/x-mathjax-config\">\n MathJax.Hub.Config({\n menuSettings: {\n CHTMLpreview: false\n },\n \"CHTML-preview\":{\n disabled: true\n },\n \"HTML-CSS\": {\n scale: 90,\n availableFonts: [],\n preferredFont: null,\n preferredFonts: null,\n webFont:\"Gyre-Pagella\",\n imageFont:'TeX',\n undefinedFamily:\"'Arial Unicode MS',serif\",\n linebreaks: { automatic: false }\n },\n \"TeX\": {\n extensions: [\"noErrors.js\"],\n noErrors: {\n inlineDelimiters: [\"\",\"\"],\n multiLine: true,\n style: {\n \"font-size\": \"90%\",\n \"text-align\": \"left\",\n \"color\": \"black\",\n \"padding\": \"1px 3px\",\n \"border\": \"1px solid\"\n }\n }\n }\n });\n \u003C/script>\u003Cscript type=\"text/javascript\" async=\"\" src=\"https://www.mdpi.com/bundles/mathjax/MathJax.js?config=TeX-AMS-MML_HTMLorMML\">\u003C/script>\n \u003Csection id=\"sec1-preprints-107672\" type=\"intro\">\u003Ch2 data-nested=\"1\" id=\"preprints-h2-1\"> 1. Introduction\u003C/h2>\n\u003Cdiv class=\"html-p\">On March 11, 2020, the Director-General of the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) pandemic, caused by severe-acute-respiratory-syndrome-related coronavirus (SARS-CoV-2) [\u003Ca href=\"#B1-preprints-107672\" class=\"html-bibr\">1\u003C/a>], and countries worldwide actively implemented classical public health measures, including quarantine, isolation, disinfection, and lockdowns. However, hopes for a vaccine grew as the general consensus was that rapid herd immunity was the best solution to overcome the pandemic. Therefore, since 2021, as a means to combat SARS-CoV-2 infection, several global pharmaceutical companies have developed various genetic vaccines that use the spike protein of the Wuhan strain of SARS-CoV-2 as an antigen, following which rapid vaccination has been promoted on a global scale [\u003Ca href=\"#B2-preprints-107672\" class=\"html-bibr\">2\u003C/a>,\u003Ca href=\"#B3-preprints-107672\" class=\"html-bibr\">3\u003C/a>]. During this period (2020-2022), virological studies on SARS-CoV-2 have been intensively conducted, and the pathogenic mechanism of this virus has been elucidated in detail [\u003Ca href=\"#B4-preprints-107672\" class=\"html-bibr\">4\u003C/a>,\u003Ca href=\"#B5-preprints-107672\" class=\"html-bibr\">5\u003C/a>]. In brief, the key pathogenic processes include binding of the spike protein of SARS-CoV-2 to the angiotensin-converting enzyme 2 receptor on vascular endothelial cells, allowing viral entry and amplification [\u003Ca href=\"#B6-preprints-107672\" class=\"html-bibr\">6\u003C/a>]; triggering of red blood cell and platelet aggregation by the spike protein [\u003Ca href=\"#B7-preprints-107672\" class=\"html-bibr\">7\u003C/a>,\u003Ca href=\"#B8-preprints-107672\" class=\"html-bibr\">8\u003C/a>,\u003Ca href=\"#B9-preprints-107672\" class=\"html-bibr\">9\u003C/a>,\u003Ca href=\"#B10-preprints-107672\" class=\"html-bibr\">10\u003C/a>,\u003Ca href=\"#B11-preprints-107672\" class=\"html-bibr\">11\u003C/a>]; and formation of microthrombi [\u003Ca href=\"#B12-preprints-107672\" class=\"html-bibr\">12\u003C/a>,\u003Ca href=\"#B13-preprints-107672\" class=\"html-bibr\">13\u003C/a>].\u003C/div>\n\u003Cdiv class=\"html-p\"> Genetic vaccines, such as mRNA vaccines that encode spike proteins, have caused a wide variety of diseases in all organs and systems of the human body, including the nervous system, in addition to thrombosis, which has resulted in cardiovascular disorders in vaccine recipients [\u003Ca href=\"#B14-preprints-107672\" class=\"html-bibr\">14\u003C/a>,\u003Ca href=\"#B15-preprints-107672\" class=\"html-bibr\">15\u003C/a>,\u003Ca href=\"#B16-preprints-107672\" class=\"html-bibr\">16\u003C/a>,\u003Ca href=\"#B17-preprints-107672\" class=\"html-bibr\">17\u003C/a>,\u003Ca href=\"#B18-preprints-107672\" class=\"html-bibr\">18\u003C/a>,\u003Ca href=\"#B19-preprints-107672\" class=\"html-bibr\">19\u003C/a>,\u003Ca href=\"#B20-preprints-107672\" class=\"html-bibr\">20\u003C/a>,\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>]. Thrombosis is induced in the vaccine recipient by the spike proteins produced from the mRNA or DNA introduced via the genetic vaccine when the foreign gene is introduced into autologous cells using gene-transfer capable lipid nanoparticles (LNPs) or other means. Although evidence for specific problems has been reported individually, Parry et al. have proposed the theory of spikeopathy (spike disease) as a hypothesis that synthesizes all of the evidence for this problem [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>]. Furthermore, two general mechanisms are proposed by which a modified gene introduced into the body by genetic vaccination as well as some of the antigens produced by its expression can be transmitted throughout the body. First, LNPs encapsulating modified mRNA can spread throughout the body via the bloodstream from the injection site and can accumulate in specific organs, such as the liver, spleen, ovaries, testes, and bone marrow [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B23-preprints-107672\" class=\"html-bibr\">23\u003C/a>]. Second, pseudouridinated mRNA molecules and synthesized spike proteins can be released as extracellular vesicles, or exosomes, from cells that have incorporated the LNPs. These exosomes are transported in the circulation throughout the body to reach various organs [\u003Ca href=\"#B24-preprints-107672\" class=\"html-bibr\">24\u003C/a>,\u003Ca href=\"#B25-preprints-107672\" class=\"html-bibr\">25\u003C/a>,\u003Ca href=\"#B26-preprints-107672\" class=\"html-bibr\">26\u003C/a>,\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>]. Furthermore, spike proteins produced by cells that have taken up the modified gene travel throughout the body in the bloodstream (\u003Ca href=\"#preprints-107672-f001\" class=\"html-fig\">Figure 1\u003C/a>) [\u003Ca href=\"#B28-preprints-107672\" class=\"html-bibr\">28\u003C/a>,\u003Ca href=\"#B29-preprints-107672\" class=\"html-bibr\">29\u003C/a>]. Thus, the risk of inducing various health conditions can be attributed to the transport, distribution, and expression of the components of the genetic vaccine beyond the administration site to organs and tissues of the whole body.\u003C/div>\n\u003Cdiv class=\"html-p\">Although the Director-General of the WHO declared the end of the COVID-19 public health emergency on May 5, 2023, post-vaccination syndrome (PVS) caused by genetic vaccines has become a major global problem [\u003Ca href=\"#B19-preprints-107672\" class=\"html-bibr\">19\u003C/a>,\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>,\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B30-preprints-107672\" class=\"html-bibr\">30\u003C/a>], requiring a reasonable harm–benefit assessment of the global use of such vaccines [\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B31-preprints-107672\" class=\"html-bibr\">31\u003C/a>,\u003Ca href=\"#B32-preprints-107672\" class=\"html-bibr\">32\u003C/a>,\u003Ca href=\"#B33-preprints-107672\" class=\"html-bibr\">33\u003C/a>]. Since the beginning of the coronavirus pandemic and following vaccination with genetic vaccines, the safety of blood products and their use in transfusions has been debated [\u003Ca href=\"#B34-preprints-107672\" class=\"html-bibr\">34\u003C/a>,\u003Ca href=\"#B35-preprints-107672\" class=\"html-bibr\">35\u003C/a>,\u003Ca href=\"#B36-preprints-107672\" class=\"html-bibr\">36\u003C/a>,\u003Ca href=\"#B37-preprints-107672\" class=\"html-bibr\">37\u003C/a>,\u003Ca href=\"#B38-preprints-107672\" class=\"html-bibr\">38\u003C/a>,\u003Ca href=\"#B39-preprints-107672\" class=\"html-bibr\">39\u003C/a>]. However, owing to a lack of understanding of the pathology of SARS-CoV-2 at the beginning of the pandemic, specific discussions, based on the data or on the analysis of the problem and its risks, were not attempted; only concerns were expressed, and no clear conclusions or policies were drawn. For example, Jacobs et al. stated that hospitals were not required to collect the genetic vaccination status of blood donors or to inform patients about the same [\u003Ca href=\"#B37-preprints-107672\" class=\"html-bibr\">37\u003C/a>] because, until 2021, health issues arising from vaccination with genetic vaccines had not been reported. Contrary to initial expectations, genes and proteins from genetic vaccines were found to persist in the blood of vaccine recipients for prolonged periods of time [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B28-preprints-107672\" class=\"html-bibr\">28\u003C/a>,\u003Ca href=\"#B40-preprints-107672\" class=\"html-bibr\">40\u003C/a>,\u003Ca href=\"#B41-preprints-107672\" class=\"html-bibr\">41\u003C/a>,\u003Ca href=\"#B42-preprints-107672\" class=\"html-bibr\">42\u003C/a>,\u003Ca href=\"#B43-preprints-107672\" class=\"html-bibr\">43\u003C/a>,\u003Ca href=\"#B44-preprints-107672\" class=\"html-bibr\">44\u003C/a>,\u003Ca href=\"#B45-preprints-107672\" class=\"html-bibr\">45\u003C/a>], causing a variety of adverse events. Roubinian et al. reported that transfusions of plasma and platelet blood components collected before and after COVID-19 vaccination were not associated with increased adverse outcomes in transfusion recipients who did not develop COVID-19 [\u003Ca href=\"#B39-preprints-107672\" class=\"html-bibr\">39\u003C/a>]. However, they only evaluated plasma and platelet preparations, not red blood cell or whole blood preparations. Moreover, the study only followed up recipients to the point of 30-day readmission rates; therefore, the long-term effects remain unclear.\u003C/div>\n\u003Cdiv class=\"html-p\">Genetic vaccines are the equivalent of biomedicine (i.e. immune therapeutics) rather than conventional vaccines in terms of their mechanism of action [\u003Ca href=\"#B46-preprints-107672\" class=\"html-bibr\">46\u003C/a>,\u003Ca href=\"#B47-preprints-107672\" class=\"html-bibr\">47\u003C/a>]. The various genetic vaccines currently treated as vaccines should originally have been treated as biomedicine; however, because they were classified as vaccines, huge numbers of people were inoculated with them [\u003Ca href=\"#B2-preprints-107672\" class=\"html-bibr\">2\u003C/a>,\u003Ca href=\"#B3-preprints-107672\" class=\"html-bibr\">3\u003C/a>]. As a result, extensive areas of medicine are now beginning to be affected because most of the population in many countries has been vaccinated [\u003Ca href=\"#B19-preprints-107672\" class=\"html-bibr\">19\u003C/a>,\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>,\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B30-preprints-107672\" class=\"html-bibr\">30\u003C/a>,\u003Ca href=\"#B48-preprints-107672\" class=\"html-bibr\">48\u003C/a>], which possibly indicates that blood products for transfusion have been affected by these genetic vaccines. Considering the volume of evidence that has recently come to light, this paper aims to raise awareness among relevant parties and suggest specific recommendations regarding the use of blood products derived from genetic vaccine recipients, including those who have received mRNA vaccines. Furthermore, this paper examines the current risks of blood transfusions when genetic vaccines are administered in large quantities. The vaccine recipients described in this paper are limited to genetic vaccine recipients.\u003C/div>\u003C/section>\u003Csection id=\"sec2-preprints-107672\" type>\u003Ch2 data-nested=\"1\" id=\"preprints-h2-2\"> 2. Overview of Cases of Blood Abnormalities after Vaccination with Genetic Vaccines\u003C/h2>\n\u003Cdiv class=\"html-p\">A wide variety of diseases related to blood and blood vessels, such as thrombosis, have developed after vaccination with genetic vaccines, including many cases of serious health injuries. For example, a PubMed search on diseases such as thrombocytopenia, thrombotic disorders with thrombocytopenia, deep vein thrombosis, thrombocytopenic purpura, cutaneous vasculitis, and sinus thrombosis combined with the essential keywords \"COVID-19 vaccine\" and \"side effects\" yielded several hundred articles in the two years since the rollout of genetic vaccines [\u003Ca href=\"#B14-preprints-107672\" class=\"html-bibr\">14\u003C/a>,\u003Ca href=\"#B17-preprints-107672\" class=\"html-bibr\">17\u003C/a>,\u003Ca href=\"#B20-preprints-107672\" class=\"html-bibr\">20\u003C/a>,\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>,\u003Ca href=\"#B49-preprints-107672\" class=\"html-bibr\">49\u003C/a>]. Microscopic observation has revealed that in addition to abnormally shaped red blood cells, amorphous material has been found floating in the blood of mRNA-vaccinated individuals, some of which has shown grossly abnormal findings (\u003Ca href=\"#preprints-107672-t001\" class=\"html-table\">Table 1\u003C/a>, point 2 and 5) [\u003Ca href=\"#B7-preprints-107672\" class=\"html-bibr\">7\u003C/a>,\u003Ca href=\"#B8-preprints-107672\" class=\"html-bibr\">8\u003C/a>,\u003Ca href=\"#B9-preprints-107672\" class=\"html-bibr\">9\u003C/a>,\u003Ca href=\"#B10-preprints-107672\" class=\"html-bibr\">10\u003C/a>,\u003Ca href=\"#B11-preprints-107672\" class=\"html-bibr\">11\u003C/a>,\u003Ca href=\"#B50-preprints-107672\" class=\"html-bibr\">50\u003C/a>]. The spike protein has amyloidogenic potential [\u003Ca href=\"#B51-preprints-107672\" class=\"html-bibr\">51\u003C/a>,\u003Ca href=\"#B52-preprints-107672\" class=\"html-bibr\">52\u003C/a>,\u003Ca href=\"#B53-preprints-107672\" class=\"html-bibr\">53\u003C/a>,\u003Ca href=\"#B54-preprints-107672\" class=\"html-bibr\">54\u003C/a>,\u003Ca href=\"#B55-preprints-107672\" class=\"html-bibr\">55\u003C/a>], is neurotoxic [\u003Ca href=\"#B56-preprints-107672\" class=\"html-bibr\">56\u003C/a>,\u003Ca href=\"#B57-preprints-107672\" class=\"html-bibr\">57\u003C/a>,\u003Ca href=\"#B58-preprints-107672\" class=\"html-bibr\">58\u003C/a>], and can cross the blood–brain barrier [\u003Ca href=\"#B59-preprints-107672\" class=\"html-bibr\">59\u003C/a>,\u003Ca href=\"#B60-preprints-107672\" class=\"html-bibr\">60\u003C/a>,\u003Ca href=\"#B61-preprints-107672\" class=\"html-bibr\">61\u003C/a>], which suggests that the spike protein used as an antigen in genetic vaccines might itself be toxic [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B62-preprints-107672\" class=\"html-bibr\">62\u003C/a>,\u003Ca href=\"#B63-preprints-107672\" class=\"html-bibr\">63\u003C/a>].\u003C/div>\n\u003Cdiv class=\"html-p\">Individuals who have received multiple doses of a genetic vaccine may have multiple exposures to the same antigen within a brief period, thereby being imprinted with a preferential immune response to that antigen [\u003Ca href=\"#B64-preprints-107672\" class=\"html-bibr\">64\u003C/a>,\u003Ca href=\"#B65-preprints-107672\" class=\"html-bibr\">65\u003C/a>,\u003Ca href=\"#B66-preprints-107672\" class=\"html-bibr\">66\u003C/a>,\u003Ca href=\"#B67-preprints-107672\" class=\"html-bibr\">67\u003C/a>]. This phenomenon, called original antigenic sin or immune imprinting, may have caused COVID-19 vaccine recipients to become more susceptible to contracting COVID-19 [\u003Ca href=\"#B68-preprints-107672\" class=\"html-bibr\">68\u003C/a>]. Moreover, such vaccine recipients are also at a risk of antibody-dependent enhancement of infection, whereby antibodies produced by vaccination promote viral infection and symptoms [\u003Ca href=\"#B69-preprints-107672\" class=\"html-bibr\">69\u003C/a>,\u003Ca href=\"#B70-preprints-107672\" class=\"html-bibr\">70\u003C/a>]. In contrast, repeated administration of genetic vaccines may result in immune tolerance because of a class switch to non-inflammatory immunoglobulin G4 (IgG4) [\u003Ca href=\"#B71-preprints-107672\" class=\"html-bibr\">71\u003C/a>,\u003Ca href=\"#B72-preprints-107672\" class=\"html-bibr\">72\u003C/a>,\u003Ca href=\"#B73-preprints-107672\" class=\"html-bibr\">73\u003C/a>,\u003Ca href=\"#B74-preprints-107672\" class=\"html-bibr\">74\u003C/a>,\u003Ca href=\"#B75-preprints-107672\" class=\"html-bibr\">75\u003C/a>,\u003Ca href=\"#B76-preprints-107672\" class=\"html-bibr\">76\u003C/a>], whereby the immune system of the recipient does not mount an excessive response such as cytokine storm [\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B77-preprints-107672\" class=\"html-bibr\">77\u003C/a>], as evidenced by case reports of IgG4-related disease [\u003Ca href=\"#B78-preprints-107672\" class=\"html-bibr\">78\u003C/a>,\u003Ca href=\"#B79-preprints-107672\" class=\"html-bibr\">79\u003C/a>,\u003Ca href=\"#B80-preprints-107672\" class=\"html-bibr\">80\u003C/a>]. Such alterations in immune function due to immune imprinting and immunoglobulin class switching to IgG4 occurring in genetic vaccine recipients is a cause for concern as these may increase the risk of serious illness due to opportunistic infections or pathogenic viruses that would not pose a problem in a normal immune system [\u003Ca href=\"#B81-preprints-107672\" class=\"html-bibr\">81\u003C/a>,\u003Ca href=\"#B82-preprints-107672\" class=\"html-bibr\">82\u003C/a>,\u003Ca href=\"#B83-preprints-107672\" class=\"html-bibr\">83\u003C/a>,\u003Ca href=\"#B84-preprints-107672\" class=\"html-bibr\">84\u003C/a>,\u003Ca href=\"#B85-preprints-107672\" class=\"html-bibr\">85\u003C/a>,\u003Ca href=\"#B86-preprints-107672\" class=\"html-bibr\">86\u003C/a>,\u003Ca href=\"#B87-preprints-107672\" class=\"html-bibr\">87\u003C/a>]. Therefore, from the perspective of traditional containment of infectious diseases, greater caution is required in the collection of blood from genetic vaccine recipients and in the subsequent handling of blood products, as well as during solid organ transplantation and even during surgical procedures [\u003Ca href=\"#B88-preprints-107672\" class=\"html-bibr\">88\u003C/a>,\u003Ca href=\"#B89-preprints-107672\" class=\"html-bibr\">89\u003C/a>,\u003Ca href=\"#B90-preprints-107672\" class=\"html-bibr\">90\u003C/a>,\u003Ca href=\"#B91-preprints-107672\" class=\"html-bibr\">91\u003C/a>,\u003Ca href=\"#B92-preprints-107672\" class=\"html-bibr\">92\u003C/a>] to avoid the risk of accidental blood-borne infections (\u003Ca href=\"#preprints-107672-t001\" class=\"html-table\">Table 1\u003C/a>, point 3) [\u003Ca href=\"#B89-preprints-107672\" class=\"html-bibr\">89\u003C/a>,\u003Ca href=\"#B90-preprints-107672\" class=\"html-bibr\">90\u003C/a>,\u003Ca href=\"#B91-preprints-107672\" class=\"html-bibr\">91\u003C/a>,\u003Ca href=\"#B92-preprints-107672\" class=\"html-bibr\">92\u003C/a>]. Although the phenomenon of immune imprinting can occur even when spike protein is not used as an antigen or when another antigen is used (e.g., inactivated influenza vaccine) [\u003Ca href=\"#B93-preprints-107672\" class=\"html-bibr\">93\u003C/a>], in case of genetic vaccines, which produce an antigen within the body, the period of exposure to the same antigen might be prolonged, resulting in the risk of immune imprinting being higher than with conventional inactivated vaccines. The duration for which vaccine components remain in the body after a person has received a genetic vaccine is yet unknown [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B40-preprints-107672\" class=\"html-bibr\">40\u003C/a>,\u003Ca href=\"#B43-preprints-107672\" class=\"html-bibr\">43\u003C/a>]; however, it is expected that they remain in the body for a longer period than that originally thought, partly based on reports of spike protein being detected in vaccinated individuals several months post vaccination (\u003Ca href=\"#preprints-107672-t001\" class=\"html-table\">Table 1\u003C/a>, point 1) [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B28-preprints-107672\" class=\"html-bibr\">28\u003C/a>,\u003Ca href=\"#B41-preprints-107672\" class=\"html-bibr\">41\u003C/a>,\u003Ca href=\"#B42-preprints-107672\" class=\"html-bibr\">42\u003C/a>]. In addition, the immune dysfunction of genetic vaccine recipients is expected to be prolonged owing to immunoglobulin class switching to IgG4 [\u003Ca href=\"#B71-preprints-107672\" class=\"html-bibr\">71\u003C/a>,\u003Ca href=\"#B73-preprints-107672\" class=\"html-bibr\">73\u003C/a>,\u003Ca href=\"#B76-preprints-107672\" class=\"html-bibr\">76\u003C/a>] due to long-term exposure to a specific identical antigen (in this case, spike protein), and also because some of the B cells that produce IgG4 are likely to differentiate into memory B cells that survive in the body for a sustained period [\u003Ca href=\"#B73-preprints-107672\" class=\"html-bibr\">73\u003C/a>,\u003Ca href=\"#B94-preprints-107672\" class=\"html-bibr\">94\u003C/a>] (\u003Ca href=\"#preprints-107672-t001\" class=\"html-table\">Table 1\u003C/a>, point 3 & 6). In contrast, modified (N1-methyl-pseudouridylated) mRNAs cause a decrease in immune function if they remain in the body for an extended period of time [\u003Ca href=\"#B76-preprints-107672\" class=\"html-bibr\">76\u003C/a>]. \u003C/div>\n\u003Cdiv class=\"html-p\">In summary, receiving blood products derived from blood collected in, at least, a brief deferral period after vaccination with genetic vaccines might pose a health risk for some patients. Although occurrence of secondary damage caused by transfusion of blood products derived from genetic vaccine recipients is yet unknown, it is vital that medical institutions and administrative organizations respond and investigate cooperatively keeping various possibilities in mind, especially considering that mechanisms such as the toxicity of the spike protein itself and the effects of LNPs and modified mRNA on the immune response have not been fully elucidated. A significant proportion of the COVID-19 PVS in mRNA vaccine recipients is due to toxic spike proteins, and the inclusion of structures in the receptor-binding domain within these proteins might induce prion disease, as Seneff et al. and Perez et al. have reported [\u003Ca href=\"#B51-preprints-107672\" class=\"html-bibr\">51\u003C/a>,\u003Ca href=\"#B95-preprints-107672\" class=\"html-bibr\">95\u003C/a>,\u003Ca href=\"#B96-preprints-107672\" class=\"html-bibr\">96\u003C/a>,\u003Ca href=\"#B97-preprints-107672\" class=\"html-bibr\">97\u003C/a>,\u003Ca href=\"#B98-preprints-107672\" class=\"html-bibr\">98\u003C/a>,\u003Ca href=\"#B99-preprints-107672\" class=\"html-bibr\">99\u003C/a>,\u003Ca href=\"#B100-preprints-107672\" class=\"html-bibr\">100\u003C/a>,\u003Ca href=\"#B101-preprints-107672\" class=\"html-bibr\">101\u003C/a>]. Furthermore, prion similarity in the receptor-binding domain exists not only in the spike protein of the Wuhan strain, which is still used as an antigen in genetic vaccines, but also in that of variants of SARS-CoV-2, such as the Delta strain, with the exception of the Omicron strain [\u003Ca href=\"#B98-preprints-107672\" class=\"html-bibr\">98\u003C/a>,\u003Ca href=\"#B102-preprints-107672\" class=\"html-bibr\">102\u003C/a>]. Further studies are required to ascertain whether uniform vigilance is required for the spike protein of all coronavirus strains or just the spike protein of certain variants, such as the Wuhan strain.\u003C/div>\u003C/section>\u003Csection id=\"sec3-preprints-107672\" type>\u003Ch2 data-nested=\"1\" id=\"preprints-h2-3\"> 3. Specific Proposals for Blood Sampling and Use of Blood Products from Vaccine Recipients\u003C/h2>\n\u003Cdiv class=\"html-p\">In the previous section, blood-related abnormalities that have occurred following vaccination with genetic vaccines were discussed. In this section, specific proposals on how to respond to these health conditions are provided. Blood contamination affects several areas of health care; therefore, it is crucial to plan beforehand and be vigilant to avoid these occurrences [\u003Ca href=\"#B100-preprints-107672\" class=\"html-bibr\">100\u003C/a>,\u003Ca href=\"#B101-preprints-107672\" class=\"html-bibr\">101\u003C/a>,\u003Ca href=\"#B103-preprints-107672\" class=\"html-bibr\">103\u003C/a>,\u003Ca href=\"#B104-preprints-107672\" class=\"html-bibr\">104\u003C/a>,\u003Ca href=\"#B105-preprints-107672\" class=\"html-bibr\">105\u003C/a>].\u003C/div>\n\u003Csection id=\"sec3dot1-preprints-107672\" type>\u003Ch4 class=\"html-italic\" data-nested=\"2\"> 3.1. Additional Requirements for Blood Collection (Donation)\u003C/h4>\n\u003Cdiv class=\"html-p\">Currently, in Japan, the Japanese Red Cross Society (\u003Ca href=\"https://www.jrc.or.jp/english/\" target=\"_blank\">https://www.jrc.or.jp/english/\u003C/a>) plays a central role in blood collection activities, and its blood products are used for blood transfusions and other purposes. The current rules of the Japanese Red Cross Society state that blood can be collected from genetic vaccine recipients after a deferral period (48 hours for mRNA vaccine recipients and 6 weeks for AstraZeneca DNA vaccine recipients); however, the data and rationale for such rules have not been specified. Similar to procedures for infections such as human immunodeficiency virus and prion diseases, a history of genetic vaccination (DNA and/or mRNA type), including timing and number of doses, should be obtained by interview when blood is collected, and maintained in the official record (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>, \u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>). Additional caution is warranted, particularly in cases where sufficient number of days have elapsed since the genetic vaccine was administered, because LNPs [\u003Ca href=\"#B23-preprints-107672\" class=\"html-bibr\">23\u003C/a>,\u003Ca href=\"#B106-preprints-107672\" class=\"html-bibr\">106\u003C/a>,\u003Ca href=\"#B107-preprints-107672\" class=\"html-bibr\">107\u003C/a>,\u003Ca href=\"#B108-preprints-107672\" class=\"html-bibr\">108\u003C/a>,\u003Ca href=\"#B109-preprints-107672\" class=\"html-bibr\">109\u003C/a>] and spike protein mRNA, which can induce inflammation, may continue to remain in the blood (\u003Ca href=\"#preprints-107672-t001\" class=\"html-table\">Table 1\u003C/a>, point 4) [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B40-preprints-107672\" class=\"html-bibr\">40\u003C/a>,\u003Ca href=\"#B43-preprints-107672\" class=\"html-bibr\">43\u003C/a>,\u003Ca href=\"#B44-preprints-107672\" class=\"html-bibr\">44\u003C/a>]. In cases where certain events such as anaphylactic shock occurred immediately after genetic vaccination, the effects of LNPs should also be suspected [\u003Ca href=\"#B110-preprints-107672\" class=\"html-bibr\">110\u003C/a>]. Negatively charged LNPs themselves interact with fibrinogen to form thrombi [\u003Ca href=\"#B111-preprints-107672\" class=\"html-bibr\">111\u003C/a>], and because LNP induces inflammation, it may cause thromboinflammation by itself [\u003Ca href=\"#B112-preprints-107672\" class=\"html-bibr\">112\u003C/a>]. Therefore, the presence of LNPs may in itself be a factor that should be viewed with caution when using transfusion products.\u003C/div>\n\u003Cdiv class=\"html-p\">In contrast, in cases where individuals underwent long COVID without receiving a genetic vaccine, the likelihood of the spike protein remaining in their body is possible; therefore, maintaining official records of the occurrence of long COVID is essential [\u003Ca href=\"#B52-preprints-107672\" class=\"html-bibr\">52\u003C/a>,\u003Ca href=\"#B113-preprints-107672\" class=\"html-bibr\">113\u003C/a>,\u003Ca href=\"#B114-preprints-107672\" class=\"html-bibr\">114\u003C/a>,\u003Ca href=\"#B115-preprints-107672\" class=\"html-bibr\">115\u003C/a>]. The degradation rates of pseudouridinated mRNA and spike protein in the body are yet unknown; therefore, blood products derived from genetic vaccine recipients should be used with extreme caution, considering that cases of AIDS, bovine spongiform encephalopathy (BSE), and variant Creutzfeldt-Jakob disease (vCJD), caused by the use of contaminated blood products, have occurred earlier [\u003Ca href=\"#B105-preprints-107672\" class=\"html-bibr\">105\u003C/a>,\u003Ca href=\"#B116-preprints-107672\" class=\"html-bibr\">116\u003C/a>,\u003Ca href=\"#B117-preprints-107672\" class=\"html-bibr\">117\u003C/a>,\u003Ca href=\"#B118-preprints-107672\" class=\"html-bibr\">118\u003C/a>,\u003Ca href=\"#B119-preprints-107672\" class=\"html-bibr\">119\u003C/a>,\u003Ca href=\"#B120-preprints-107672\" class=\"html-bibr\">120\u003C/a>,\u003Ca href=\"#B121-preprints-107672\" class=\"html-bibr\">121\u003C/a>,\u003Ca href=\"#B122-preprints-107672\" class=\"html-bibr\">122\u003C/a>,\u003Ca href=\"#B123-preprints-107672\" class=\"html-bibr\">123\u003C/a>].\u003C/div>\u003C/section>\u003Csection id=\"sec3dot2-preprints-107672\" type>\u003Ch4 class=\"html-italic\" data-nested=\"2\"> 3.2. Handling of Existing Blood Products\u003C/h4>\n\u003Cdiv class=\"html-p\">Currently, the genetic vaccination status of blood donors is not confirmed or controlled by organizations, including medical institutions, and the use of blood collected from such donors for transfusions may pose risks to patients. Therefore, when blood products derived from genetic vaccine recipients are used, it is necessary to confirm the presence or absence of spike protein or modified mRNA as performed in tests for pathogens (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>, \u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>). Presence of spike protein or modified mRNA should be quantified by an immunochemical enzyme-linked immunosorbent assay, immunophenotyping, direct mass spectrometry of the protein itself, exosome-based liquid biopsy as used in cancer screening, or PCR [\u003Ca href=\"#B28-preprints-107672\" class=\"html-bibr\">28\u003C/a>,\u003Ca href=\"#B29-preprints-107672\" class=\"html-bibr\">29\u003C/a>,\u003Ca href=\"#B124-preprints-107672\" class=\"html-bibr\">124\u003C/a>,\u003Ca href=\"#B125-preprints-107672\" class=\"html-bibr\">125\u003C/a>,\u003Ca href=\"#B126-preprints-107672\" class=\"html-bibr\">126\u003C/a>,\u003Ca href=\"#B127-preprints-107672\" class=\"html-bibr\">127\u003C/a>,\u003Ca href=\"#B128-preprints-107672\" class=\"html-bibr\">128\u003C/a>,\u003Ca href=\"#B129-preprints-107672\" class=\"html-bibr\">129\u003C/a>,\u003Ca href=\"#B130-preprints-107672\" class=\"html-bibr\">130\u003C/a>]. For protein assays, mass spectrometry could be used as an initial step to identify and quantify the spike protein itself in blood [\u003Ca href=\"#B28-preprints-107672\" class=\"html-bibr\">28\u003C/a>,\u003Ca href=\"#B126-preprints-107672\" class=\"html-bibr\">126\u003C/a>] as it may take time to generate a good-quality anti-spike protein antibody or a positive control for a recombinant spike protein to be compared with, and to sort and distribute them to each laboratory. Concurrently, the components of the spike protein-induced amyloid material should be analyzed [\u003Ca href=\"#B52-preprints-107672\" class=\"html-bibr\">52\u003C/a>,\u003Ca href=\"#B131-preprints-107672\" class=\"html-bibr\">131\u003C/a>], and once identified, these could be used as biomarkers in future studies. Furthermore, exosome analysis could also be used for these investigations because spike proteins and the genes encoding them are circulated throughout the body by exosomes (\u003Ca href=\"#preprints-107672-f001\" class=\"html-fig\">Figure 1\u003C/a>) [\u003Ca href=\"#B24-preprints-107672\" class=\"html-bibr\">24\u003C/a>,\u003Ca href=\"#B25-preprints-107672\" class=\"html-bibr\">25\u003C/a>,\u003Ca href=\"#B26-preprints-107672\" class=\"html-bibr\">26\u003C/a>,\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>].\u003C/div>\n\u003Cdiv class=\"html-p\">Although it is essential to remove the spike protein or a modified gene derived from the genetic vaccine if found in a blood product, currently, there is no reliable way to do so. The presence of a prion-like structure within the spike protein molecule [\u003Ca href=\"#B96-preprints-107672\" class=\"html-bibr\">96\u003C/a>,\u003Ca href=\"#B100-preprints-107672\" class=\"html-bibr\">100\u003C/a>,\u003Ca href=\"#B101-preprints-107672\" class=\"html-bibr\">101\u003C/a>] suggests that this molecule may be a persistent, sparingly soluble, heat-resistant, and radiation-resistant protein [\u003Ca href=\"#B132-preprints-107672\" class=\"html-bibr\">132\u003C/a>,\u003Ca href=\"#B133-preprints-107672\" class=\"html-bibr\">133\u003C/a>]. The prion protein can be inactivated by thiocyanate, hydroxide, and hypochlorite [\u003Ca href=\"#B134-preprints-107672\" class=\"html-bibr\">134\u003C/a>,\u003Ca href=\"#B135-preprints-107672\" class=\"html-bibr\">135\u003C/a>,\u003Ca href=\"#B136-preprints-107672\" class=\"html-bibr\">136\u003C/a>]; however, whether these methods can be applied to the spike protein and the resulting amyloid materials is not yet known. Notably, Nattokinase, an alkaline protease, degrades spike proteins \u003Cspan class=\"html-italic\">in vitro\u003C/span> [\u003Ca href=\"#B137-preprints-107672\" class=\"html-bibr\">137\u003C/a>]. Although further studies are needed to determine whether such enzymes are indeed effective in degrading spike proteins, it is worth noting that Nattokinase is already known as an alternative in the prevention and treatment of cardiovascular diseases [\u003Ca href=\"#B138-preprints-107672\" class=\"html-bibr\">138\u003C/a>,\u003Ca href=\"#B139-preprints-107672\" class=\"html-bibr\">139\u003C/a>,\u003Ca href=\"#B140-preprints-107672\" class=\"html-bibr\">140\u003C/a>]. Currently, however, there are no methods to reliably remove the pathogenic protein or mRNA; therefore, it might not be prudent to use all such blood products until a definitive solution is found. Some medical facilities might not be able to dispose of blood products immediately; therefore, in such cases, the transfusion consent form provided to the patient should include the possibility of blood products being contaminated with spike protein or other foreign substances. In any case, to prevent and reduce medical accidents caused by contaminated blood, it is imperative to underscore the importance of confirming the history and frequency of vaccination with genetic vaccines at the time of blood collection; this information should be documented as an official record, managed and stored by both medical and governmental organizations (see \u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>, \u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>).\u003C/div>\u003C/section>\u003Csection id=\"sec3dot3-preprints-107672\" type>\u003Ch4 class=\"html-italic\" data-nested=\"2\"> 3.3. Need for Regular Checkups and Cohort Studies to Gain a Complete Picture of Blood Components\u003C/h4>\n\u003Cdiv class=\"html-p\">The residual status of spike protein or modified gene fragments derived from genetic vaccines in the blood of vaccinated individuals is currently unknown; it might be useful to include the measurement of these molecules in routine health checkups. It would also be prudent to include a section in the routine medical checkup questionnaire to check genetic vaccination status and the number of vaccinations received to obtain an overall picture of the residual status of spike proteins in the blood. A variety of conditions following genetic vaccination involve thrombosis and immunological conditions [\u003Ca href=\"#B12-preprints-107672\" class=\"html-bibr\">12\u003C/a>,\u003Ca href=\"#B14-preprints-107672\" class=\"html-bibr\">14\u003C/a>,\u003Ca href=\"#B16-preprints-107672\" class=\"html-bibr\">16\u003C/a>,\u003Ca href=\"#B17-preprints-107672\" class=\"html-bibr\">17\u003C/a>,\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>,\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B71-preprints-107672\" class=\"html-bibr\">71\u003C/a>,\u003Ca href=\"#B73-preprints-107672\" class=\"html-bibr\">73\u003C/a>]; therefore, abnormalities in blood components related to these events should also be analyzed.\u003C/div>\n\u003Cdiv class=\"html-p\">Transmission of spike protein was observed when mice that had not been vaccinated with the genetic vaccine were administered exosomes collected from vaccine recipients [\u003Ca href=\"#B25-preprints-107672\" class=\"html-bibr\">25\u003C/a>], thus proving that the spike protein and its modified genes can be transmitted through exosomes. Therefore, full testing should be done initially, regardless of genetic vaccination status, and a cohort study should be conducted to quickly identify all components derived from genetic vaccines (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>). Although such measures involve steady, labor-intensive efforts that require collaboration between all parties involved, the subsequent analyses may lead to the development of diagnostic criteria and testing for COVID-19 PVS. In addition, even those individuals who have not been vaccinated with the genetic vaccine, but have had long COVID, may have residual spike proteins or fibrin-derived microthrombi in their bodies; therefore, the same testing and follow-up as that for genetic vaccine recipients should be conducted for such individuals. [\u003Ca href=\"#B52-preprints-107672\" class=\"html-bibr\">52\u003C/a>,\u003Ca href=\"#B53-preprints-107672\" class=\"html-bibr\">53\u003C/a>,\u003Ca href=\"#B113-preprints-107672\" class=\"html-bibr\">113\u003C/a>,\u003Ca href=\"#B114-preprints-107672\" class=\"html-bibr\">114\u003C/a>,\u003Ca href=\"#B115-preprints-107672\" class=\"html-bibr\">115\u003C/a>]. The presence or absence and amount of anti-nucleocapsid antibodies as well as that of antibody isotypes may be an indicator(s) in distinguishing whether vaccination with genetic vaccines or long COVID resulted in the presence of residual spike proteins or fibrin-derived microthrombi in their bodies (\u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>, point 10) [\u003Ca href=\"#B141-preprints-107672\" class=\"html-bibr\">141\u003C/a>,\u003Ca href=\"#B142-preprints-107672\" class=\"html-bibr\">142\u003C/a>,\u003Ca href=\"#B143-preprints-107672\" class=\"html-bibr\">143\u003C/a>]. Further, these cohort studies would help establish cutoff values for blood levels of spike protein and other substances to determine the safety of blood products. Faksova et al. conducted a large cohort study of 99 million people using a multinational Global Vaccine Data Network™ and found a significantly increased risk of myocarditis, pericarditis, Guillain-Barre syndrome, and cerebral venous sinus thrombosis in genetic vaccine recipients [\u003Ca href=\"#B144-preprints-107672\" class=\"html-bibr\">144\u003C/a>]. Such studies will be increasingly necessary in the future.\u003C/div>\u003C/section>\u003Csection id=\"sec3dot4-preprints-107672\" type>\u003Ch4 class=\"html-italic\" data-nested=\"2\"> 3.4. Need for Expedited Development of Clinical Practice Guidelines and Diagnostic Criteria for COVID-19 PVS\u003C/h4>\n\u003Cdiv class=\"html-p\">Although the spectrum of COVID-19 PVS is diverse, it is mostly characterized by a high prevalence of hematologic and immune-related diseases [\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>]. Thus, regardless of the transfusion issues discussed in this paper, blood tests are likely to be the first step in the diagnosis of COVID-19 PVS. The ability to rapidly develop highly accurate testing systems, particularly blood tests, will be critical in treating patients with COVID-19 PVS. Additional meta-analysis of data from systematic reviews and cohort analyses will be needed to prevent bias in diagnostic criteria and to develop appropriate clinical practice guidelines (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>) [\u003Ca href=\"#B145-preprints-107672\" class=\"html-bibr\">145\u003C/a>,\u003Ca href=\"#B146-preprints-107672\" class=\"html-bibr\">146\u003C/a>,\u003Ca href=\"#B147-preprints-107672\" class=\"html-bibr\">147\u003C/a>].\u003C/div>\u003C/section>\u003C/section>\u003Csection id=\"sec4-preprints-107672\" type>\u003Ch2 data-nested=\"1\" id=\"preprints-h2-4\"> 4. Effects of Blood Transfusion from Genetic Vaccine Recipients and the Need for Traceability of Blood Products for Transfusion\u003C/h2>\n\u003Cdiv class=\"html-p\">There has been considerable debate regarding the safety of blood products for transfusion prepared from blood donated by vaccine recipients [\u003Ca href=\"#B36-preprints-107672\" class=\"html-bibr\">36\u003C/a>,\u003Ca href=\"#B37-preprints-107672\" class=\"html-bibr\">37\u003C/a>,\u003Ca href=\"#B38-preprints-107672\" class=\"html-bibr\">38\u003C/a>,\u003Ca href=\"#B39-preprints-107672\" class=\"html-bibr\">39\u003C/a>]. However, the effect of a genetic vaccine, such as an mRNA vaccine, on the human body is yet unknown, although cases of encephalitis caused by blood transfusion from dengue vaccine recipients have been reported as recently as 2023 [\u003Ca href=\"#B148-preprints-107672\" class=\"html-bibr\">148\u003C/a>], indicating that the current system for managing and tracking blood products is not adequate. Unless accurate tests are established, no conclusions can be drawn about the risk or safety of blood transfusions using blood products from genetic vaccine recipients. Therefore, thorough and continuous investigation is necessary, which can be accomplished by registering all potential donors, ensuring traceability of blood products, and maintaining rigorous recipient outcome studies and meta-analysis. Furthermore, it is essential to rigorously obtain a history of vaccination and COVID-19 infection from donors, preserve official records, and store samples of blood products for later detection and verification of substances such as spike proteins and exosomes (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>). Given the wide variety of tests and records, the movement of people around the world, and the import/export of blood products, it may be necessary in the future to establish traceability by introducing blockchain technology into the management of blood products while maintaining anonymity [\u003Ca href=\"#B149-preprints-107672\" class=\"html-bibr\">149\u003C/a>,\u003Ca href=\"#B150-preprints-107672\" class=\"html-bibr\">150\u003C/a>].\u003C/div>\u003C/section>\u003Csection id=\"sec5-preprints-107672\" type>\u003Ch2 data-nested=\"1\" id=\"preprints-h2-5\"> 5. Need for the Development of Relevant Legislation\u003C/h2>\n\u003Cdiv class=\"html-p\">In Japan, the \"Act on Prevention of Infectious Diseases and Medical Care for Patients with Infectious Diseases\" (\u003Ca href=\"https://www.japaneselawtranslation.go.jp/en/laws/view/2830/en\" target=\"_blank\">https://www.japaneselawtranslation.go.jp/en/laws/view/2830/en\u003C/a>) and \"Act on Organ Transplantation\" have been enacted to prevent the spread of infectious diseases through blood products and to handle organ transplants, respectively. The Ministry of Health, Labour and Welfare has issued the \"Guidelines for Blood Transfusion Therapy\" regarding blood transfusions. These laws and guidelines specify the responsibilities of the public, physicians, and national and local governments and protect the rights of citizens. However, the spike protein, used as an antigen, or its gene, are not organisms; therefore, certain legal decisions are required, such as how to legally define the pathogenicity of the spike protein. Thus, a new definition of the spike protein—as a nonbiological infection, may be necessary with increasing clarity on its toxicity and pathogenicity [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B62-preprints-107672\" class=\"html-bibr\">62\u003C/a>]. Subsequently, when the risks of and health injuries caused by blood products derived from genetic vaccination recipients have been roughly clarified (\u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>), it will be essential to formulate regulations to reduce and prevent risks and contamination. This can be achieved by developing related laws with the participation of the legislative branch, legal experts, medical administration personnel, healthcare providers, and medical researchers, and by taking measures such as checking vaccination status and dates and legally regulating the import/export of blood products (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>). The entire process requires coordination between agencies and healthcare professionals from the outset.\u003C/div>\n\u003Cdiv class=\"html-p\">In contrast to previous drug programs, vaccination with genetic vaccines was implemented simultaneously for a substantial number of people on a global scale [\u003Ca href=\"#B2-preprints-107672\" class=\"html-bibr\">2\u003C/a>,\u003Ca href=\"#B3-preprints-107672\" class=\"html-bibr\">3\u003C/a>]; therefore, legislation and international treaties need to urgently and explicitly elucidate bilateral and multilateral agreements among countries regarding the management of blood products. These legal frameworks should delineate regulations governing the handling of blood products and establish protocols for governmental compensation and response to issues and hazards associated with these products, including penalties and prohibitions. The International Health Regulations 2005 [\u003Ca href=\"#B151-preprints-107672\" class=\"html-bibr\">151\u003C/a>,\u003Ca href=\"#B152-preprints-107672\" class=\"html-bibr\">152\u003C/a>] could be used for this purpose; however, considering the WHO's strong push for vaccination with genetic vaccines [\u003Ca href=\"#B153-preprints-107672\" class=\"html-bibr\">153\u003C/a>], another framework may be needed. As described in \u003Ca href=\"#sec3dot3-preprints-107672\" class=\"html-sec\">Section 3.3\u003C/a> of this article, it might also be necessary for countries to conduct active epidemiological surveys [\u003Ca href=\"#B154-preprints-107672\" class=\"html-bibr\">154\u003C/a>], as was the case with COVID-19, compile the results of these surveys, and establish an international organization tasked with monitoring response efforts and assessing damages within each country (\u003Ca href=\"#preprints-107672-f003\" class=\"html-fig\">Figure 3\u003C/a>). For such decisions, it is vital to incorporate not only the perspective of infectious diseases but also that of biosafety and biosecurity [\u003Ca href=\"#B152-preprints-107672\" class=\"html-bibr\">152\u003C/a>,\u003Ca href=\"#B155-preprints-107672\" class=\"html-bibr\">155\u003C/a>]. Thus, there is an urgent need for an international conference of various experts, including policymakers, legal experts, historians, and ethicists, to discuss in a transparent manner what problems and challenges might arise from genetic vaccines and beyond [\u003Ca href=\"#B156-preprints-107672\" class=\"html-bibr\">156\u003C/a>,\u003Ca href=\"#B157-preprints-107672\" class=\"html-bibr\">157\u003C/a>,\u003Ca href=\"#B158-preprints-107672\" class=\"html-bibr\">158\u003C/a>,\u003Ca href=\"#B159-preprints-107672\" class=\"html-bibr\">159\u003C/a>].\u003C/div>\n\u003Cdiv class=\"html-p\">In Japan, Article 15 (2) of the Infectious Disease Act (\u003Ca href=\"https://www.japaneselawtranslation.go.jp/ja/laws/view/2830/en#je_ch3at5\" target=\"_blank\">https://www.japaneselawtranslation.go.jp/ja/laws/view/2830/en#je_ch3at5\u003C/a>) stipulates that the Japanese government is responsible for conducting epidemiological studies. Considering the significant health risks associated with COVID-19 PVS, we urge the Japanese government to prioritize the analysis and safety verification of blood products derived from genetic vaccine recipients.\u003C/div>\u003C/section>\u003Csection id=\"sec6-preprints-107672\" type>\u003Ch2 data-nested=\"1\" id=\"preprints-h2-6\"> 6. Further Considerations\u003C/h2>\n\u003Cdiv class=\"html-p\">To address the need for developing methods to identify and remove spike proteins and modified genes derived from genetic vaccines from blood products, the Japanese Society of Hematology (\u003Ca href=\"http://www.jshem.or.jp/modules/en/index.php?content_id=1\" target=\"_blank\">http://www.jshem.or.jp/modules/en/index.php?content_id=1\u003C/a>), the Japanese Society of Transfusion and Cell Therapy (\u003Ca href=\"http://yuketsu.jstmct.or.jp/en/\" target=\"_blank\">http://yuketsu.jstmct.or.jp/en/\u003C/a>), and related organizations need to develop guidelines on how to handle blood products that contain residual spike proteins or their modified genes ensuring that a uniform inspection standard is developed. Additionally, as noted earlier, vaccination with genetic vaccines has been promoted on a global scale [\u003Ca href=\"#B2-preprints-107672\" class=\"html-bibr\">2\u003C/a>,\u003Ca href=\"#B3-preprints-107672\" class=\"html-bibr\">3\u003C/a>], which will necessitate coordination and exchange of information with national administrations and relevant international medical societies (\u003Ca href=\"#preprints-107672-f002\" class=\"html-fig\">Figure 2\u003C/a>). Furthermore, international guidelines on the handling of blood products and the establishment of an international investigatory organization will be necessary (\u003Ca href=\"#preprints-107672-f003\" class=\"html-fig\">Figure 3\u003C/a>). There is an urgent need to share the risks of transfusion of blood products derived from genetic vaccine recipients among the parties concerned, and prompt investigation and response by all parties concerned is essential. \u003C/div>\n\u003Cdiv class=\"html-p\">During the course of the development of various guidelines, previous responses to such health emergencies should be considered; for example, when the transmission of BSE and vCJD, also through blood transfusion, was a health issue (e.g., the Creutzfeldt-Jakob Disease International Surveillance Network in \u003Ca href=\"https://www.eurocjd.ed.ac.uk/\" target=\"_blank\">https://www.eurocjd.ed.ac.uk/\u003C/a>) [\u003Ca href=\"#B105-preprints-107672\" class=\"html-bibr\">105\u003C/a>,\u003Ca href=\"#B116-preprints-107672\" class=\"html-bibr\">116\u003C/a>,\u003Ca href=\"#B117-preprints-107672\" class=\"html-bibr\">117\u003C/a>,\u003Ca href=\"#B123-preprints-107672\" class=\"html-bibr\">123\u003C/a>,\u003Ca href=\"#B160-preprints-107672\" class=\"html-bibr\">160\u003C/a>]. In the case of BSE in the United Kingdom, the mode of transmission of prion protein was unknown; therefore, leukodepletion of blood products was conducted universally. Whether this action was effective in preventing transmission of BSE and vCJD through blood products is controversial [\u003Ca href=\"#B105-preprints-107672\" class=\"html-bibr\">105\u003C/a>,\u003Ca href=\"#B122-preprints-107672\" class=\"html-bibr\">122\u003C/a>,\u003Ca href=\"#B123-preprints-107672\" class=\"html-bibr\">123\u003C/a>,\u003Ca href=\"#B161-preprints-107672\" class=\"html-bibr\">161\u003C/a>]; however, removing white blood cells from all blood products was not common at that time, as is now routinely done with collected blood. Nevertheless, because of leukodepletion, the safety of blood products has increased [\u003Ca href=\"#B162-preprints-107672\" class=\"html-bibr\">162\u003C/a>]. In the case of the spike protein, which causes abnormalities such as agglutination of red blood cells and platelets [\u003Ca href=\"#B8-preprints-107672\" class=\"html-bibr\">8\u003C/a>,\u003Ca href=\"#B9-preprints-107672\" class=\"html-bibr\">9\u003C/a>,\u003Ca href=\"#B10-preprints-107672\" class=\"html-bibr\">10\u003C/a>,\u003Ca href=\"#B11-preprints-107672\" class=\"html-bibr\">11\u003C/a>,\u003Ca href=\"#B50-preprints-107672\" class=\"html-bibr\">50\u003C/a>], leukodepletion alone will not resolve the issue. Thus, it is worth confirming whether washing of red blood cells can be effective [\u003Ca href=\"#B163-preprints-107672\" class=\"html-bibr\">163\u003C/a>,\u003Ca href=\"#B164-preprints-107672\" class=\"html-bibr\">164\u003C/a>]; in urgent cases, autotransfusion may be an option [\u003Ca href=\"#B165-preprints-107672\" class=\"html-bibr\">165\u003C/a>].\u003C/div>\n\u003Cdiv class=\"html-p\">Recent studies have shown that RNA pseudouridylation can result in frameshifting [\u003Ca href=\"#B166-preprints-107672\" class=\"html-bibr\">166\u003C/a>]; however, whether a portion of the pseudouridinated mRNA for the spike protein is translated into another protein of unknown function in vaccine recipients is yet unknown. Moreover, if these proteins are also pathogenic, additional testing for such frameshift proteins may be needed in the future. Even if a frameshift protein is not toxic, it is foreign to the body and could cause an autoimmune reaction. In addition, as described in \u003Ca href=\"#sec3dot1-preprints-107672\" class=\"html-sec\">Section 3.1\u003C/a>, LNPs themselves are highly inflammatory substances [\u003Ca href=\"#B23-preprints-107672\" class=\"html-bibr\">23\u003C/a>,\u003Ca href=\"#B106-preprints-107672\" class=\"html-bibr\">106\u003C/a>,\u003Ca href=\"#B107-preprints-107672\" class=\"html-bibr\">107\u003C/a>,\u003Ca href=\"#B109-preprints-107672\" class=\"html-bibr\">109\u003C/a>,\u003Ca href=\"#B110-preprints-107672\" class=\"html-bibr\">110\u003C/a>]; however, LNPs exhibit stronger adjuvant activity than the adjuvants used in conventional vaccines [\u003Ca href=\"#B167-preprints-107672\" class=\"html-bibr\">167\u003C/a>], and could result in autoimmune diseases (\u003Ca href=\"#preprints-107672-t001\" class=\"html-table\">Table 1\u003C/a>, point 4) [\u003Ca href=\"#B168-preprints-107672\" class=\"html-bibr\">168\u003C/a>,\u003Ca href=\"#B169-preprints-107672\" class=\"html-bibr\">169\u003C/a>]. Thus, although the causative agent of autoimmune disease is not yet known, the large number of reported cases of autoimmune disease following genetic vaccination is a concern [\u003Ca href=\"#B15-preprints-107672\" class=\"html-bibr\">15\u003C/a>,\u003Ca href=\"#B21-preprints-107672\" class=\"html-bibr\">21\u003C/a>,\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B30-preprints-107672\" class=\"html-bibr\">30\u003C/a>,\u003Ca href=\"#B169-preprints-107672\" class=\"html-bibr\">169\u003C/a>,\u003Ca href=\"#B170-preprints-107672\" class=\"html-bibr\">170\u003C/a>]. The very mechanism of genetic vaccines that induces one's own cells to produce antigens of the pathogen carries the risk of inducing autoimmune diseases, which cannot be completely avoided even if mRNA pseudouridylation technology is used. Thus, individuals with a positive blood test for spike protein may need to undergo interviews and additional tests for autoimmune disease indicators, such as for antinuclear antibodies (\u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>, point 4) [\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B169-preprints-107672\" class=\"html-bibr\">169\u003C/a>,\u003Ca href=\"#B171-preprints-107672\" class=\"html-bibr\">171\u003C/a>,\u003Ca href=\"#B172-preprints-107672\" class=\"html-bibr\">172\u003C/a>]. Alternatively, if the amino acid sequence of the protein resulting from such a frameshift is predictable, these candidate proteins could be included in the initial mass spectrometry assay (\u003Ca href=\"#preprints-107672-t002\" class=\"html-table\">Table 2\u003C/a>, point 6). Thus, it is particularly important to develop tests and establish medical care settings in anticipation of these situations.\u003C/div>\u003C/section>\u003Csection id=\"sec7-preprints-107672\" type>\u003Ch2 data-nested=\"1\" id=\"preprints-h2-7\"> 7. Conclusion\u003C/h2>\n\u003Cdiv class=\"html-p\">Finally, the use of genetic vaccines, such as pseudouridinated mRNAs and mRNA-LNP platforms [\u003Ca href=\"#B47-preprints-107672\" class=\"html-bibr\">47\u003C/a>,\u003Ca href=\"#B108-preprints-107672\" class=\"html-bibr\">108\u003C/a>], should be reviewed critically to avoid further risks similar to those described in this paper. The impact of these genetic vaccines on blood products and the actual damage caused by them are unknown at present. Furthermore, the issues discussed in this paper pertain to all organ transplants, including bone marrow transplants, and not just blood products. Therefore, in order to avoid these risks and prevent further expansion of the potential for blood contamination and complication of the situation, we suggest that the vaccination campaign using genetic vaccines should proceed with caution and that a harm–benefit assessment be carried out, as called for by Fraiman et al. and Polykretis et al. [\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B31-preprints-107672\" class=\"html-bibr\">31\u003C/a>,\u003Ca href=\"#B32-preprints-107672\" class=\"html-bibr\">32\u003C/a>,\u003Ca href=\"#B33-preprints-107672\" class=\"html-bibr\">33\u003C/a>]. Moreover, as Parry et al. stated [\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>], it is critical and timely to reevaluate the pseudouridinated mRNA based technology before the advent of other genetic vaccines that are being developed. The health injuries caused by vaccination with genetic vaccines cannot be ignored; therefore, countries and relevant organizations should take concrete steps together to identify the risks and to control and resolve them.\u003C/div>\u003C/section>\n \n \u003Csection class=\"html-notes\">\u003Ch2 id=\"preprints-h2-8\">Author Contributions\u003C/h2>\n\u003Cdiv class=\"html-p\">Conceptualization, J.U., M.F. and A.F.; investigation, J.U., H.M., Y.M., M.F. and A.F.; resources, Y.H.; data curation, J.U., H.M., M.F. and A.F.; writing—original draft preparation, J.U.; writing—review and editing, J.U., H.M., Y.H., K.Y., Y.M., M.F. and A.F.; visualization, J.U.; supervision, J.U., M.F. and A.F.; project administration, J.U., M.F. and A.F. All authors have read and agreed to the published version of the manuscript.\u003C/div>\u003C/section>\u003Csection class=\"html-notes\">\u003Ch2 id=\"preprints-h2-9\">Funding\u003C/h2>\n\u003Cdiv class=\"html-p\">This research received no external funding.\u003C/div>\u003C/section>\u003Csection class=\"html-notes\">\u003Ch2 id=\"preprints-h2-10\">Institutional Review Board Statement\u003C/h2>\n\u003Cdiv class=\"html-p\">Not applicable.\u003C/div>\u003C/section>\u003Csection class=\"html-notes\">\u003Ch2 id=\"preprints-h2-11\">Conflicts of Interest\u003C/h2>\n\u003Cdiv class=\"html-p\">The authors declare no conflict of interest in connection with this research.\u003C/div>\u003C/section>\u003Csection id=\"html-references_list\">\u003Ch2 id=\"preprints-h2-12\">References\u003C/h2>\n\u003Col class=\"html-xxx\">\n\u003Cli id=\"B1-preprints-107672\" class=\"html-x\" data-content=\"1.\">Sohrabi, C.; Alsafi, Z.; O'Neill, N.; Khan, M.; Kerwan, A.; Al-Jabir, A.; Iosifidis, C.; Agha, R. , World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). \u003Cspan class=\"html-italic\">International Journal of Surgery\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">76\u003C/span>, 71–76. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+World+Health+Organization+declares+global+emergency:+A+review+of+the+2019+novel+coronavirus+(COVID-19)&author=Sohrabi,+C.&author=Alsafi,+Z.&author=O'Neill,+N.&author=Khan,+M.&author=Kerwan,+A.&author=Al-Jabir,+A.&author=Iosifidis,+C.&author=Agha,+R.&publication_year=2020&journal=International+Journal+of+Surgery&volume=76&pages=71%E2%80%9376&doi=10.1016/j.ijsu.2020.02.034&pmid=32112977\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ijsu.2020.02.034\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/32112977\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B2-preprints-107672\" class=\"html-x\" data-content=\"2.\">Francis, A. I.; Ghany, S.; Gilkes, T.; Umakanthan, S. , Review of COVID-19 vaccine subtypes, efficacy and geographical distributions. \u003Cspan class=\"html-italic\">Postgraduate Medical Journal\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">98\u003C/span>, 389–94. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Review+of+COVID-19+vaccine+subtypes,+efficacy+and+geographical+distributions&author=Francis,+A.+I.&author=Ghany,+S.&author=Gilkes,+T.&author=Umakanthan,+S.&publication_year=2022&journal=Postgraduate+Medical+Journal&volume=98&pages=389%E2%80%9394&doi=10.1136/postgradmedj-2021-140654&pmid=37066438\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1136/postgradmedj-2021-140654\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/37066438\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B3-preprints-107672\" class=\"html-x\" data-content=\"3.\">Patel, R.; Kaki, M.; Potluri, V. S.; Kahar, P.; Khanna, D. , A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & Johnson. \u003Cspan class=\"html-italic\">Human Vaccines & Immunotherapeutics 2022, 18\u003C/span>.\u003C/li>\n\u003Cli id=\"B4-preprints-107672\" class=\"html-x\" data-content=\"4.\">Harrison, A. G.; Lin, T.; Wang, P. , Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. \u003Cspan class=\"html-italic\">Trends in Immunology\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">41\u003C/span>, 1100–15. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Mechanisms+of+SARS-CoV-2+Transmission+and+Pathogenesis&author=Harrison,+A.+G.&author=Lin,+T.&author=Wang,+P.&publication_year=2020&journal=Trends+in+Immunology&volume=41&pages=1100%E2%80%9315&doi=10.1016/j.it.2020.10.004&pmid=33132005\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.it.2020.10.004\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33132005\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B5-preprints-107672\" class=\"html-x\" data-content=\"5.\">Lamers, M. M.; Haagmans, B. L. , SARS-CoV-2 pathogenesis. \u003Cspan class=\"html-italic\">Nature Reviews Microbiology\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">20\u003C/span>, 270–84. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+pathogenesis&author=Lamers,+M.+M.&author=Haagmans,+B.+L.&publication_year=2022&journal=Nature+Reviews+Microbiology&volume=20&pages=270%E2%80%9384&doi=10.1038/s41579-022-00713-0&pmid=35354968\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41579-022-00713-0\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35354968\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B6-preprints-107672\" class=\"html-x\" data-content=\"6.\">Lan, J.; Ge, J.; Yu, J.; Shan, S.; Zhou, H.; Fan, S.; Zhang, Q.; Shi, X.; Wang, Q.; Zhang, L.; Wang, X. , Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. \u003Cspan class=\"html-italic\">Nature\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">581\u003C/span>, 215–20. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Structure+of+the+SARS-CoV-2+spike+receptor-binding+domain+bound+to+the+ACE2+receptor&author=Lan,+J.&author=Ge,+J.&author=Yu,+J.&author=Shan,+S.&author=Zhou,+H.&author=Fan,+S.&author=Zhang,+Q.&author=Shi,+X.&author=Wang,+Q.&author=Zhang,+L.&publication_year=2020&journal=Nature&volume=581&pages=215%E2%80%9320&doi=10.1038/s41586-020-2180-5\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41586-020-2180-5\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B7-preprints-107672\" class=\"html-x\" data-content=\"7.\">Zhang, S.; Liu, Y.; Wang, X.; Yang, L.; Li, H.; Wang, Y.; Liu, M.; Zhao, X.; Xie, Y.; Yang, Y.; Zhang, S.; Fan, Z.; Dong, J.; Yuan, Z.; Ding, Z.; Zhang, Y.; Hu, L. , SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. \u003Cspan class=\"html-italic\">Journal of Hematology & Oncology 2020, 13\u003C/span>.\u003C/li>\n\u003Cli id=\"B8-preprints-107672\" class=\"html-x\" data-content=\"8.\">Berzuini, A.; Bianco, C.; Migliorini, A. C.; Maggioni, M.; Valenti, L.; Prati, D. , Red blood cell morphology in patients with COVID-19-related anaemia. \u003Cspan class=\"html-italic\">Blood Transfus\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">19\u003C/span>, 34–36. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Red+blood+cell+morphology+in+patients+with+COVID-19-related+anaemia&author=Berzuini,+A.&author=Bianco,+C.&author=Migliorini,+A.+C.&author=Maggioni,+M.&author=Valenti,+L.&author=Prati,+D.&publication_year=2021&journal=Blood+Transfus&volume=19&pages=34%E2%80%9336&pmid=32955421\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/32955421\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B9-preprints-107672\" class=\"html-x\" data-content=\"9.\">Melkumyants, A.; Buryachkovskaya, L.; Lomakin, N.; Antonova, O.; Serebruany, V. , Mild COVID-19 and Impaired Blood Cell–Endothelial Crosstalk: Considering Long-Term Use of Antithrombotics? \u003Cspan class=\"html-italic\">Thrombosis and Haemostasis\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">122\u003C/span>, 123–30. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Mild+COVID-19+and+Impaired+Blood+Cell%E2%80%93Endothelial+Crosstalk:+Considering+Long-Term+Use+of+Antithrombotics?&author=Melkumyants,+A.&author=Buryachkovskaya,+L.&author=Lomakin,+N.&author=Antonova,+O.&author=Serebruany,+V.&publication_year=2021&journal=Thrombosis+and+Haemostasis&volume=122&pages=123%E2%80%9330&doi=10.1055/a-1551-9911\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1055/a-1551-9911\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B10-preprints-107672\" class=\"html-xx\" data-content=\"10.\">Boschi, C.; Scheim, D. E.; Bancod, A.; Militello, M.; Bideau, M. L.; Colson, P.; Fantini, J.; Scola, B. L. , SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects. \u003Cspan class=\"html-italic\">International Journal of Molecular Sciences\u003C/span> \u003Cb>2022\u003C/b>, 23. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Spike+Protein+Induces+Hemagglutination:+Implications+for+COVID-19+Morbidities+and+Therapeutics+and+for+Vaccine+Adverse+Effects&author=Boschi,+C.&author=Scheim,+D.+E.&author=Bancod,+A.&author=Militello,+M.&author=Bideau,+M.+L.&author=Colson,+P.&author=Fantini,+J.&author=Scola,+B.+L.&publication_year=2022&journal=International+Journal+of+Molecular+Sciences&pages=23&doi=10.3390/ijms232415480\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/ijms232415480\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B11-preprints-107672\" class=\"html-xx\" data-content=\"11.\">Scheim, D. E. , A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody. \u003Cspan class=\"html-italic\">International Journal of Molecular Sciences\u003C/span> \u003Cb>2022\u003C/b>, 23. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+A+Deadly+Embrace:+Hemagglutination+Mediated+by+SARS-CoV-2+Spike+Protein+at+Its+22+N-Glycosylation+Sites,+Red+Blood+Cell+Surface+Sialoglycoproteins,+and+Antibody&author=Scheim,+D.+E.&publication_year=2022&journal=International+Journal+of+Molecular+Sciences&pages=23&doi=10.3390/ijms23052558\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/ijms23052558\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B12-preprints-107672\" class=\"html-xx\" data-content=\"12.\">McFadyen, J. D.; Stevens, H.; Peter, K. , The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications. \u003Cspan class=\"html-italic\">Circulation Research\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">127\u003C/span>, 571–87. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+Emerging+Threat+of+(Micro)Thrombosis+in+COVID-19+and+Its+Therapeutic+Implications&author=McFadyen,+J.+D.&author=Stevens,+H.&author=Peter,+K.&publication_year=2020&journal=Circulation+Research&volume=127&pages=571%E2%80%9387&doi=10.1161/CIRCRESAHA.120.317447\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1161/CIRCRESAHA.120.317447\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B13-preprints-107672\" class=\"html-xx\" data-content=\"13.\">13. Grobbelaar, Lize M.; Venter, C.; Vlok, M.; Ngoepe, M.; Laubscher, Gert J.; Lourens, Petrus J.; Steenkamp, J.; Kell, Douglas B.; Pretorius, E., SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. \u003Cspan class=\"html-italic\">Bioscience Reports 2021, 41\u003C/span>.\u003C/li>\n\u003Cli id=\"B14-preprints-107672\" class=\"html-xx\" data-content=\"14.\">Bilotta, C.; Perrone, G.; Adelfio, V.; Spatola, G. F.; Uzzo, M. L.; Argo, A.; Zerbo, S. , COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis. \u003Cspan class=\"html-italic\">Front Immunol\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">12\u003C/span>, 729251. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+COVID-19+Vaccine-Related+Thrombosis:+A+Systematic+Review+and+Exploratory+Analysis&author=Bilotta,+C.&author=Perrone,+G.&author=Adelfio,+V.&author=Spatola,+G.+F.&author=Uzzo,+M.+L.&author=Argo,+A.&author=Zerbo,+S.&publication_year=2021&journal=Front+Immunol&volume=12&pages=729251&doi=10.3389/fimmu.2021.729251&pmid=34912330\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3389/fimmu.2021.729251\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34912330\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B15-preprints-107672\" class=\"html-xx\" data-content=\"15.\">Garg, R. K.; Paliwal, V. K. , Spectrum of neurological complications following COVID-19 vaccination. \u003Cspan class=\"html-italic\">Neurological Sciences\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">43\u003C/span>, 3–40. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Spectrum+of+neurological+complications+following+COVID-19+vaccination&author=Garg,+R.+K.&author=Paliwal,+V.+K.&publication_year=2021&journal=Neurological+Sciences&volume=43&pages=3%E2%80%9340&doi=10.1007/s10072-021-05662-9&pmid=34719776\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1007/s10072-021-05662-9\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34719776\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B16-preprints-107672\" class=\"html-xx\" data-content=\"16.\">Oldenburg, J.; Klamroth, R.; Langer, F.; Albisetti, M.; von Auer, C.; Ay, C.; Korte, W.; Scharf, R. E.; Pötzsch, B.; Greinacher, A. , Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH. \u003Cspan class=\"html-italic\">Hämostaseologie 2021, 41, (03), 184-89\u003C/span>.\u003C/li>\n\u003Cli id=\"B17-preprints-107672\" class=\"html-xx\" data-content=\"17.\">Sharifian-Dorche, M.; Bahmanyar, M.; Sharifian-Dorche, A.; Mohammadi, P.; Nomovi, M.; Mowla, A. , Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review. \u003Cspan class=\"html-italic\">J Neurol Sci\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">428\u003C/span>, 117607. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Vaccine-induced+immune+thrombotic+thrombocytopenia+and+cerebral+venous+sinus+thrombosis+post+COVID-19+vaccination;+a+systematic+review&author=Sharifian-Dorche,+M.&author=Bahmanyar,+M.&author=Sharifian-Dorche,+A.&author=Mohammadi,+P.&author=Nomovi,+M.&author=Mowla,+A.&publication_year=2021&journal=J+Neurol+Sci&volume=428&pages=117607&doi=10.1016/j.jns.2021.117607&pmid=34365148\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.jns.2021.117607\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34365148\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B18-preprints-107672\" class=\"html-xx\" data-content=\"18.\">Lane, S.; Yeomans, A.; Shakir, S. , Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: a systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature. \u003Cspan class=\"html-italic\">BMJ Open\u003C/span> \u003Cb>2022\u003C/b>, 12. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Reports+of+myocarditis+and+pericarditis+following+mRNA+COVID-19+vaccination:+a+systematic+review+of+spontaneously+reported+data+from+the+UK,+Europe+and+the+USA+and+of+the+scientific+literature&author=Lane,+S.&author=Yeomans,+A.&author=Shakir,+S.&publication_year=2022&journal=BMJ+Open&pages=12&doi=10.1136/bmjopen-2021-059223&pmid=35613761\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1136/bmjopen-2021-059223\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35613761\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B19-preprints-107672\" class=\"html-xx\" data-content=\"19.\">Oster, M. E.; Shay, D. K.; Su, J. R.; Gee, J.; Creech, C. B.; Broder, K. R.; Edwards, K.; Soslow, J. H.; Dendy, J. M.; Schlaudecker, E.; Lang, S. M.; Barnett, E. D.; Ruberg, F. L.; Smith, M. J.; Campbell, M. J.; Lopes, R. D.; Sperling, L. S.; Baumblatt, J. A.; Thompson, D. L.; Marquez, P. L.; Strid, P.; Woo, J.; Pugsley, R.; Reagan-Steiner, S.; DeStefano, F.; Shimabukuro, T. T. , Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021. \u003Cspan class=\"html-italic\">Jama\u003C/span> \u003Cb>2022\u003C/b>, 327. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Myocarditis+Cases+Reported+After+mRNA-Based+COVID-19+Vaccination+in+the+US+From+December+2020+to+August+2021&author=Oster,+M.+E.&author=Shay,+D.+K.&author=Su,+J.+R.&author=Gee,+J.&author=Creech,+C.+B.&author=Broder,+K.+R.&author=Edwards,+K.&author=Soslow,+J.+H.&author=Dendy,+J.+M.&author=Schlaudecker,+E.&publication_year=2022&journal=Jama&pages=327&doi=10.1001/jama.2021.24110&pmid=35076665\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1001/jama.2021.24110\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35076665\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B20-preprints-107672\" class=\"html-xx\" data-content=\"20.\">Yasmin, F.; Najeeb, H.; Naeem, U.; Moeed, A.; Atif, A. R.; Asghar, M. S.; Nimri, N.; Saleem, M.; Bandyopadhyay, D.; Krittanawong, C.; Fadelallah Eljack, M. M.; Tahir, M. J.; Waqar, F. , Adverse events following COVID-19 mRNA vaccines: A systematic review of cardiovascular complication, thrombosis, and thrombocytopenia. \u003Cspan class=\"html-italic\">Immun Inflamm Dis\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">11\u003C/span>, e807. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Adverse+events+following+COVID-19+mRNA+vaccines:+A+systematic+review+of+cardiovascular+complication,+thrombosis,+and+thrombocytopenia&author=Yasmin,+F.&author=Najeeb,+H.&author=Naeem,+U.&author=Moeed,+A.&author=Atif,+A.+R.&author=Asghar,+M.+S.&author=Nimri,+N.&author=Saleem,+M.&author=Bandyopadhyay,+D.&author=Krittanawong,+C.&publication_year=2023&journal=Immun+Inflamm+Dis&volume=11&pages=e807&doi=10.1002/iid3.807&pmid=36988252\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1002/iid3.807\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36988252\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B21-preprints-107672\" class=\"html-xx\" data-content=\"21.\">Konishi, N.; Hirai, Y.; Hikota, H.; Miyahara, S.; Fujisawa, A.; Motohashi, H.; Ueda, J.; Inoue, M.; Fukushima, M. , Quantifying side effects of COVID-19 vaccines: A PubMed survey of papers on diseases as side effects presented at academic conferences in Japan. Rinsho Hyoka (Clinical Evaluation) 2024; 51. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Quantifying+side+effects+of+COVID-19+vaccines:+A+PubMed+survey+of+papers+on+diseases+as+side+effects+presented+at+academic+conferences+in+Japan&conference=Rinsho+Hyoka+(Clinical+Evaluation)+2024&author=Konishi,+N.&author=Hirai,+Y.&author=Hikota,+H.&author=Miyahara,+S.&author=Fujisawa,+A.&author=Motohashi,+H.&author=Ueda,+J.&author=Inoue,+M.&author=Fukushima,+M.&publication_year=51\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>]\u003C/li>\n\u003Cli id=\"B22-preprints-107672\" class=\"html-xx\" data-content=\"22.\">Parry, P. I.; Lefringhausen, A.; Turni, C.; Neil, C. J.; Cosford, R.; Hudson, N. J.; Gillespie, J. , ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA. \u003Cspan class=\"html-italic\">Biomedicines\u003C/span> \u003Cb>2023\u003C/b>, 11. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+%E2%80%98Spikeopathy%E2%80%99:+COVID-19+Spike+Protein+Is+Pathogenic,+from+Both+Virus+and+Vaccine+mRNA&author=Parry,+P.+I.&author=Lefringhausen,+A.&author=Turni,+C.&author=Neil,+C.+J.&author=Cosford,+R.&author=Hudson,+N.+J.&author=Gillespie,+J.&publication_year=2023&journal=Biomedicines&pages=11&doi=10.3390/biomedicines11082287&pmid=37626783\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/biomedicines11082287\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/37626783\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B23-preprints-107672\" class=\"html-xx\" data-content=\"23.\">Ndeupen, S.; Qin, Z.; Jacobsen, S.; Bouteau, A.; Estanbouli, H.; Igyártó, B. Z. , The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. \u003Cspan class=\"html-italic\">iScience\u003C/span> \u003Cb>2021\u003C/b>, 24. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+mRNA-LNP+platform's+lipid+nanoparticle+component+used+in+preclinical+vaccine+studies+is+highly+inflammatory&author=Ndeupen,+S.&author=Qin,+Z.&author=Jacobsen,+S.&author=Bouteau,+A.&author=Estanbouli,+H.&author=Igy%C3%A1rt%C3%B3,+B.+Z.&publication_year=2021&journal=iScience&pages=24\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>]\u003C/li>\n\u003Cli id=\"B24-preprints-107672\" class=\"html-xx\" data-content=\"24.\">Maugeri, M.; Nawaz, M.; Papadimitriou, A.; Angerfors, A.; Camponeschi, A.; Na, M.; Hölttä, M.; Skantze, P.; Johansson, S.; Sundqvist, M.; Lindquist, J.; Kjellman, T.; Mårtensson, I.-L.; Jin, T.; Sunnerhagen, P.; Östman, S.; Lindfors, L.; Valadi, H. , Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells. \u003Cspan class=\"html-italic\">Nature Communications\u003C/span> \u003Cb>2019\u003C/b>, 10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Linkage+between+endosomal+escape+of+LNP-mRNA+and+loading+into+EVs+for+transport+to+other+cells&author=Maugeri,+M.&author=Nawaz,+M.&author=Papadimitriou,+A.&author=Angerfors,+A.&author=Camponeschi,+A.&author=Na,+M.&author=H%C3%B6ltt%C3%A4,+M.&author=Skantze,+P.&author=Johansson,+S.&author=Sundqvist,+M.&publication_year=2019&journal=Nature+Communications&pages=10&doi=10.1038/s41467-019-12275-6\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41467-019-12275-6\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B25-preprints-107672\" class=\"html-xx\" data-content=\"25.\">Bansal, S.; Perincheri, S.; Fleming, T.; Poulson, C.; Tiffany, B.; Bremner, R. M.; Mohanakumar, T. , Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines. \u003Cspan class=\"html-italic\">The Journal of Immunology\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">207\u003C/span>, 2405–10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Cutting+Edge:+Circulating+Exosomes+with+COVID+Spike+Protein+Are+Induced+by+BNT162b2+(Pfizer%E2%80%93BioNTech)+Vaccination+prior+to+Development+of+Antibodies:+A+Novel+Mechanism+for+Immune+Activation+by+mRNA+Vaccines&author=Bansal,+S.&author=Perincheri,+S.&author=Fleming,+T.&author=Poulson,+C.&author=Tiffany,+B.&author=Bremner,+R.+M.&author=Mohanakumar,+T.&publication_year=2021&journal=The+Journal+of+Immunology&volume=207&pages=2405%E2%80%9310&doi=10.4049/jimmunol.2100637\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.4049/jimmunol.2100637\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B26-preprints-107672\" class=\"html-xx\" data-content=\"26.\">Seneff, S.; Nigh, G.; Kyriakopoulos, A. M.; McCullough, P. A. , Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. \u003Cspan class=\"html-italic\">Food Chem Toxicol\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">164\u003C/span>, 113008. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Innate+immune+suppression+by+SARS-CoV-2+mRNA+vaccinations:+The+role+of+G-quadruplexes,+exosomes,+and+MicroRNAs&author=Seneff,+S.&author=Nigh,+G.&author=Kyriakopoulos,+A.+M.&author=McCullough,+P.+A.&publication_year=2022&journal=Food+Chem+Toxicol&volume=164&pages=113008&doi=10.1016/j.fct.2022.113008\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.fct.2022.113008\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B27-preprints-107672\" class=\"html-xx\" data-content=\"27.\">Polykretis, P.; Donzelli, A.; Lindsay, J. C.; Wiseman, D.; Kyriakopoulos, A. M.; Mörz, M.; Bellavite, P.; Fukushima, M.; Seneff, S.; McCullough, P. A. , Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues. \u003Cspan class=\"html-italic\">Autoimmunity\u003C/span> \u003Cb>2023\u003C/b>, 56. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Autoimmune+inflammatory+reactions+triggered+by+the+COVID-19+genetic+vaccines+in+terminally+differentiated+tissues&author=Polykretis,+P.&author=Donzelli,+A.&author=Lindsay,+J.+C.&author=Wiseman,+D.&author=Kyriakopoulos,+A.+M.&author=M%C3%B6rz,+M.&author=Bellavite,+P.&author=Fukushima,+M.&author=Seneff,+S.&author=McCullough,+P.+A.&publication_year=2023&journal=Autoimmunity&pages=56&doi=10.1080/08916934.2023.2259123&pmid=37710966\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1080/08916934.2023.2259123\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/37710966\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B28-preprints-107672\" class=\"html-xx\" data-content=\"28.\">Brogna, C.; Cristoni, S.; Marino, G.; Montano, L.; Viduto, V.; Fabrowski, M.; Lettieri, G.; Piscopo, M. , Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS-CoV-2: Possible molecular mechanisms. \u003Cspan class=\"html-italic\">Proteomics Clin Appl\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">17\u003C/span>, e2300048. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Detection+of+recombinant+Spike+protein+in+the+blood+of+individuals+vaccinated+against+SARS-CoV-2:+Possible+molecular+mechanisms&author=Brogna,+C.&author=Cristoni,+S.&author=Marino,+G.&author=Montano,+L.&author=Viduto,+V.&author=Fabrowski,+M.&author=Lettieri,+G.&author=Piscopo,+M.&publication_year=2023&journal=Proteomics+Clin+Appl&volume=17&pages=e2300048&doi=10.1002/prca.202300048&pmid=37650258\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1002/prca.202300048\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/37650258\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B29-preprints-107672\" class=\"html-xx\" data-content=\"29.\">Yonker, L. M.; Swank, Z.; Bartsch, Y. C.; Burns, M. D.; Kane, A.; Boribong, B. P.; Davis, J. P.; Loiselle, M.; Novak, T.; Senussi, Y.; Cheng, C. A.; Burgess, E.; Edlow, A. G.; Chou, J.; Dionne, A.; Balaguru, D.; Lahoud-Rahme, M.; Arditi, M.; Julg, B.; Randolph, A. G.; Alter, G.; Fasano, A.; Walt, D. R. , Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. \u003Cspan class=\"html-italic\">Circulation\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">147\u003C/span>, 867–76. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Circulating+Spike+Protein+Detected+in+Post-COVID-19+mRNA+Vaccine+Myocarditis&author=Yonker,+L.+M.&author=Swank,+Z.&author=Bartsch,+Y.+C.&author=Burns,+M.+D.&author=Kane,+A.&author=Boribong,+B.+P.&author=Davis,+J.+P.&author=Loiselle,+M.&author=Novak,+T.&author=Senussi,+Y.&publication_year=2023&journal=Circulation&volume=147&pages=867%E2%80%9376&doi=10.1161/CIRCULATIONAHA.122.061025\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1161/CIRCULATIONAHA.122.061025\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B30-preprints-107672\" class=\"html-xx\" data-content=\"30.\">Chen, Y.; Xu, Z.; Wang, P.; Li, X. M.; Shuai, Z. W.; Ye, D. Q.; Pan, H. F. , New-onset autoimmune phenomena post-COVID-19 vaccination. \u003Cspan class=\"html-italic\">Immunology\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">165\u003C/span>, 386–401. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+New-onset+autoimmune+phenomena+post-COVID-19+vaccination&author=Chen,+Y.&author=Xu,+Z.&author=Wang,+P.&author=Li,+X.+M.&author=Shuai,+Z.+W.&author=Ye,+D.+Q.&author=Pan,+H.+F.&publication_year=2022&journal=Immunology&volume=165&pages=386%E2%80%93401&doi=10.1111/imm.13443&pmid=34957554\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/imm.13443\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34957554\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B31-preprints-107672\" class=\"html-xx\" data-content=\"31.\">Polykretis, P.; McCullough, P. A. , Rational harm-benefit assessments by age group are required for continued COVID-19 vaccination. \u003Cspan class=\"html-italic\">Scandinavian Journal of Immunology\u003C/span> \u003Cb>2022\u003C/b>, 98. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Rational+harm-benefit+assessments+by+age+group+are+required+for+continued+COVID-19+vaccination&author=Polykretis,+P.&author=McCullough,+P.+A.&publication_year=2022&journal=Scandinavian+Journal+of+Immunology&pages=98&doi=10.1111/sji.13242&pmid=38441161\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/sji.13242\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/38441161\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B32-preprints-107672\" class=\"html-xx\" data-content=\"32.\">Fraiman, J.; Erviti, J.; Jones, M.; Greenland, S.; Whelan, P.; Kaplan, R. M.; Doshi, P. , Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. \u003Cspan class=\"html-italic\">Vaccine\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">40\u003C/span>, 5798–805. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Serious+adverse+events+of+special+interest+following+mRNA+COVID-19+vaccination+in+randomized+trials+in+adults&author=Fraiman,+J.&author=Erviti,+J.&author=Jones,+M.&author=Greenland,+S.&author=Whelan,+P.&author=Kaplan,+R.+M.&author=Doshi,+P.&publication_year=2022&journal=Vaccine&volume=40&pages=5798%E2%80%93805&doi=10.1016/j.vaccine.2022.08.036&pmid=36055877\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.vaccine.2022.08.036\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36055877\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B33-preprints-107672\" class=\"html-xx\" data-content=\"33.\">Bardosh, K.; Krug, A.; Jamrozik, E.; Lemmens, T.; Keshavjee, S.; Prasad, V.; Makary, M. A.; Baral, S.; Høeg, T. B. , COVID-19 vaccine boosters for young adults: a risk benefit assessment and ethical analysis of mandate policies at universities. \u003Cspan class=\"html-italic\">Journal of Medical Ethics\u003C/span> \u003Cb>2024\u003C/b>, \u003Cspan class=\"html-italic\">50\u003C/span>, 126–38. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+COVID-19+vaccine+boosters+for+young+adults:+a+risk+benefit+assessment+and+ethical+analysis+of+mandate+policies+at+universities&author=Bardosh,+K.&author=Krug,+A.&author=Jamrozik,+E.&author=Lemmens,+T.&author=Keshavjee,+S.&author=Prasad,+V.&author=Makary,+M.+A.&author=Baral,+S.&author=H%C3%B8eg,+T.+B.&publication_year=2024&journal=Journal+of+Medical+Ethics&volume=50&pages=126%E2%80%9338&doi=10.1136/jme-2022-108449&pmid=36600579\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1136/jme-2022-108449\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36600579\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B34-preprints-107672\" class=\"html-xx\" data-content=\"34.\">Stanworth, S. J.; New, H. V.; Apelseth, T. O.; Brunskill, S.; Cardigan, R.; Doree, C.; Germain, M.; Goldman, M.; Massey, E.; Prati, D.; Shehata, N.; So-Osman, C.; Thachil, J. , Effects of the COVID-19 pandemic on supply and use of blood for transfusion. \u003Cspan class=\"html-italic\">The Lancet Haematology\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">7\u003C/span>, e756–e64. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Effects+of+the+COVID-19+pandemic+on+supply+and+use+of+blood+for+transfusion&author=Stanworth,+S.+J.&author=New,+H.+V.&author=Apelseth,+T.+O.&author=Brunskill,+S.&author=Cardigan,+R.&author=Doree,+C.&author=Germain,+M.&author=Goldman,+M.&author=Massey,+E.&author=Prati,+D.&publication_year=2020&journal=The+Lancet+Haematology&volume=7&pages=e756%E2%80%93e64&doi=10.1016/S2352-3026(20)30186-1\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/S2352-3026(20)30186-1\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B35-preprints-107672\" class=\"html-xx\" data-content=\"35.\">Chang, L.; Yan, Y.; Wang, L. , Coronavirus Disease 2019: Coronaviruses and Blood Safety. \u003Cspan class=\"html-italic\">Transfusion Medicine Reviews\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">34\u003C/span>, 75–80. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Coronavirus+Disease+2019:+Coronaviruses+and+Blood+Safety&author=Chang,+L.&author=Yan,+Y.&author=Wang,+L.&publication_year=2020&journal=Transfusion+Medicine+Reviews&volume=34&pages=75%E2%80%9380&doi=10.1016/j.tmrv.2020.02.003\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.tmrv.2020.02.003\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B36-preprints-107672\" class=\"html-xx\" data-content=\"36.\">Bouhou, S.; Lahjouji, K.; Masrar, A. , Blood donor eligibility after COVID-19 vaccination: the current state of recommendations. \u003Cspan class=\"html-italic\">Pan Afr Med J\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">40\u003C/span>, 207. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Blood+donor+eligibility+after+COVID-19+vaccination:+the+current+state+of+recommendations&author=Bouhou,+S.&author=Lahjouji,+K.&author=Masrar,+A.&publication_year=2021&journal=Pan+Afr+Med+J&volume=40&pages=207&doi=10.11604/pamj.2021.40.207.29119&pmid=35136470\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.11604/pamj.2021.40.207.29119\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35136470\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B37-preprints-107672\" class=\"html-xx\" data-content=\"37.\">Jacobs, J. W.; Bibb, L. A.; Savani, B. N.; Booth, G. S. , Refusing blood transfusions from COVID-19-vaccinated donors: are we repeating history? \u003Cspan class=\"html-italic\">British Journal of Haematology\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">196\u003C/span>, 585–88. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Refusing+blood+transfusions+from+COVID-19-vaccinated+donors:+are+we+repeating+history?&author=Jacobs,+J.+W.&author=Bibb,+L.+A.&author=Savani,+B.+N.&author=Booth,+G.+S.&publication_year=2021&journal=British+Journal+of+Haematology&volume=196&pages=585%E2%80%9388&doi=10.1111/bjh.17842&pmid=34523736\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/bjh.17842\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34523736\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B38-preprints-107672\" class=\"html-xx\" data-content=\"38.\">Hunain, R.; Uday, U.; Rackimuthu, S.; Nawaz, F. A.; Narain, K.; Essar, M. Y.; Rehman, M. U.; Ahmad, S.; Butt, A. , Effects of SARS-CoV-2 vaccination on blood donation and blood banks in India. \u003Cspan class=\"html-italic\">Ann Med Surg (Lond)\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">78\u003C/span>, 103772. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Effects+of+SARS-CoV-2+vaccination+on+blood+donation+and+blood+banks+in+India&author=Hunain,+R.&author=Uday,+U.&author=Rackimuthu,+S.&author=Nawaz,+F.+A.&author=Narain,+K.&author=Essar,+M.+Y.&author=Rehman,+M.+U.&author=Ahmad,+S.&author=Butt,+A.&publication_year=2022&journal=Ann+Med+Surg+(Lond)&volume=78&pages=103772&doi=10.1016/j.amsu.2022.103772\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.amsu.2022.103772\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B39-preprints-107672\" class=\"html-xx\" data-content=\"39.\">Roubinian, N. H.; Greene, J.; Liu, V. X.; Lee, C.; Mark, D. G.; Vinson, D. R.; Spencer, B. R.; Bruhn, R.; Bravo, M.; Stone, M.; Custer, B.; Kleinman, S.; Busch, M. P.; Norris, P. J. , Clinical outcomes in hospitalized plasma and platelet transfusion recipients prior to and following widespread blood donor SARS-CoV-2 infection and vaccination. \u003Cspan class=\"html-italic\">Transfusion\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">64\u003C/span>, 53–67. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Clinical+outcomes+in+hospitalized+plasma+and+platelet+transfusion+recipients+prior+to+and+following+widespread+blood+donor+SARS-CoV-2+infection+and+vaccination&author=Roubinian,+N.+H.&author=Greene,+J.&author=Liu,+V.+X.&author=Lee,+C.&author=Mark,+D.+G.&author=Vinson,+D.+R.&author=Spencer,+B.+R.&author=Bruhn,+R.&author=Bravo,+M.&author=Stone,+M.&publication_year=2023&journal=Transfusion&volume=64&pages=53%E2%80%9367&doi=10.1111/trf.17616\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/trf.17616\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B40-preprints-107672\" class=\"html-xx\" data-content=\"40.\">Fertig, T. E.; Chitoiu, L.; Marta, D. S.; Ionescu, V.-S.; Cismasiu, V. B.; Radu, E.; Angheluta, G.; Dobre, M.; Serbanescu, A.; Hinescu, M. E.; Gherghiceanu, M. , Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination. \u003Cspan class=\"html-italic\">Biomedicines\u003C/span> \u003Cb>2022\u003C/b>, 10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Vaccine+mRNA+Can+Be+Detected+in+Blood+at+15+Days+Post-Vaccination&author=Fertig,+T.+E.&author=Chitoiu,+L.&author=Marta,+D.+S.&author=Ionescu,+V.-S.&author=Cismasiu,+V.+B.&author=Radu,+E.&author=Angheluta,+G.&author=Dobre,+M.&author=Serbanescu,+A.&author=Hinescu,+M.+E.&publication_year=2022&journal=Biomedicines&pages=10&doi=10.3390/biomedicines10071538\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/biomedicines10071538\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B41-preprints-107672\" class=\"html-xx\" data-content=\"41.\">Mörz, M. , A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19. \u003Cspan class=\"html-italic\">Vaccines\u003C/span> \u003Cb>2022\u003C/b>, 10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+A+Case+Report:+Multifocal+Necrotizing+Encephalitis+and+Myocarditis+after+BNT162b2+mRNA+Vaccination+against+COVID-19&author=M%C3%B6rz,+M.&publication_year=2022&journal=Vaccines&pages=10&doi=10.3390/vaccines10101651&pmid=36298516\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/vaccines10101651\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36298516\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B42-preprints-107672\" class=\"html-xx\" data-content=\"42.\">Yamamoto, M.; Kase, M.; Sano, H.; Kamijima, R.; Sano, S. , Persistent varicella zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion. \u003Cspan class=\"html-italic\">Journal of Cutaneous Immunology and Allergy\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">6\u003C/span>, 18–23. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Persistent+varicella+zoster+virus+infection+following+mRNA+COVID-19+vaccination+was+associated+with+the+presence+of+encoded+spike+protein+in+the+lesion&author=Yamamoto,+M.&author=Kase,+M.&author=Sano,+H.&author=Kamijima,+R.&author=Sano,+S.&publication_year=2022&journal=Journal+of+Cutaneous+Immunology+and+Allergy&volume=6&pages=18%E2%80%9323&doi=10.1002/cia2.12278\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1002/cia2.12278\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B43-preprints-107672\" class=\"html-xx\" data-content=\"43.\">Castruita, J. A. S.; Schneider, U. V.; Mollerup, S.; Leineweber, T. D.; Weis, N.; Bukh, J.; Pedersen, M. S.; Westh, H. , SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination. \u003Cspan class=\"html-italic\">APMIS\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">131\u003C/span>, 128–32. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+mRNA+vaccine+sequences+circulate+in+blood+up+to+28+days+after+COVID-19+vaccination&author=Castruita,+J.+A.+S.&author=Schneider,+U.+V.&author=Mollerup,+S.&author=Leineweber,+T.+D.&author=Weis,+N.&author=Bukh,+J.&author=Pedersen,+M.+S.&author=Westh,+H.&publication_year=2023&journal=APMIS&volume=131&pages=128%E2%80%9332&doi=10.1111/apm.13294\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/apm.13294\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B44-preprints-107672\" class=\"html-xx\" data-content=\"44.\">Krauson, A. J.; Casimero, F. V. C.; Siddiquee, Z.; Stone, J. R. , Duration of SARS-CoV-2 mRNA vaccine persistence and factors associated with cardiac involvement in recently vaccinated patients. \u003Cspan class=\"html-italic\">NPJ Vaccines\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">8\u003C/span>, 141. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Duration+of+SARS-CoV-2+mRNA+vaccine+persistence+and+factors+associated+with+cardiac+involvement+in+recently+vaccinated+patients&author=Krauson,+A.+J.&author=Casimero,+F.+V.+C.&author=Siddiquee,+Z.&author=Stone,+J.+R.&publication_year=2023&journal=NPJ+Vaccines&volume=8&pages=141&doi=10.1038/s41541-023-00742-7\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41541-023-00742-7\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B45-preprints-107672\" class=\"html-xx\" data-content=\"45.\">Sano, S.; Yamamoto, M.; Kamijima, R.; Sano, H. , SARS-CoV-2 spike protein found in the acrosyringium and eccrine gland of repetitive miliaria-like lesions in a woman following mRNA vaccination. \u003Cspan class=\"html-italic\">J Dermatol\u003C/span> \u003Cb>2024\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+protein+found+in+the+acrosyringium+and+eccrine+gland+of+repetitive+miliaria-like+lesions+in+a+woman+following+mRNA+vaccination&author=Sano,+S.&author=Yamamoto,+M.&author=Kamijima,+R.&author=Sano,+H.&publication_year=2024&journal=J+Dermatol&doi=10.1111/1346-8138.17204\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/1346-8138.17204\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B46-preprints-107672\" class=\"html-xx\" data-content=\"46.\">Xu, S.; Yang, K.; Li, R.; Zhang, L. , mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection. \u003Cspan class=\"html-italic\">Int J Mol Sci\u003C/span> \u003Cb>2020\u003C/b>, 21. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+mRNA+Vaccine+Era-Mechanisms,+Drug+Platform+and+Clinical+Prospection&author=Xu,+S.&author=Yang,+K.&author=Li,+R.&author=Zhang,+L.&publication_year=2020&journal=Int+J+Mol+Sci&pages=21&doi=10.3390/ijms21186582&pmid=32916818\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/ijms21186582\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/32916818\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B47-preprints-107672\" class=\"html-xx\" data-content=\"47.\">Bitounis, D.; Jacquinet, E.; Rogers, M. A.; Amiji, M. M. , Strategies to reduce the risks of mRNA drug and vaccine toxicity. \u003Cspan class=\"html-italic\">Nat Rev Drug Discov\u003C/span> \u003Cb>2024\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Strategies+to+reduce+the+risks+of+mRNA+drug+and+vaccine+toxicity&author=Bitounis,+D.&author=Jacquinet,+E.&author=Rogers,+M.+A.&author=Amiji,+M.+M.&publication_year=2024&journal=Nat+Rev+Drug+Discov&doi=10.1038/s41573-023-00859-3&pmid=38263456\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41573-023-00859-3\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/38263456\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B48-preprints-107672\" class=\"html-xx\" data-content=\"48.\">Yamamoto, K. , Adverse effects of COVID-19 vaccines and measures to prevent them. \u003Cspan class=\"html-italic\">Virology Journal\u003C/span> \u003Cb>2022\u003C/b>, 19. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Adverse+effects+of+COVID-19+vaccines+and+measures+to+prevent+them&author=Yamamoto,+K.&publication_year=2022&journal=Virology+Journal&pages=19&doi=10.1186/s12985-022-01831-0&pmid=35659687\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1186/s12985-022-01831-0\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35659687\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B49-preprints-107672\" class=\"html-xx\" data-content=\"49.\">Rodriguez, Y.; Rojas, M.; Beltran, S.; Polo, F.; Camacho-Dominguez, L.; Morales, S. D.; Gershwin, M. E.; Anaya, J. M. , Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review. \u003Cspan class=\"html-italic\">J Autoimmun\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">132\u003C/span>, 102898. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Autoimmune+and+autoinflammatory+conditions+after+COVID-19+vaccination.+New+case+reports+and+updated+literature+review&author=Rodriguez,+Y.&author=Rojas,+M.&author=Beltran,+S.&author=Polo,+F.&author=Camacho-Dominguez,+L.&author=Morales,+S.+D.&author=Gershwin,+M.+E.&author=Anaya,+J.+M.&publication_year=2022&journal=J+Autoimmun&volume=132&pages=102898&doi=10.1016/j.jaut.2022.102898&pmid=36041291\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.jaut.2022.102898\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36041291\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B50-preprints-107672\" class=\"html-xx\" data-content=\"50.\">Perico, L.; Morigi, M.; Galbusera, M.; Pezzotta, A.; Gastoldi, S.; Imberti, B.; Perna, A.; Ruggenenti, P.; Donadelli, R.; Benigni, A.; Remuzzi, G. , SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation. \u003Cspan class=\"html-italic\">Front Immunol\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">13\u003C/span>, 827146. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Spike+Protein+1+Activates+Microvascular+Endothelial+Cells+and+Complement+System+Leading+to+Platelet+Aggregation&author=Perico,+L.&author=Morigi,+M.&author=Galbusera,+M.&author=Pezzotta,+A.&author=Gastoldi,+S.&author=Imberti,+B.&author=Perna,+A.&author=Ruggenenti,+P.&author=Donadelli,+R.&author=Benigni,+A.&publication_year=2022&journal=Front+Immunol&volume=13&pages=827146&doi=10.3389/fimmu.2022.827146&pmid=35320941\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3389/fimmu.2022.827146\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35320941\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B51-preprints-107672\" class=\"html-xx\" data-content=\"51.\">Idrees, D.; Kumar, V. , SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. \u003Cspan class=\"html-italic\">Biochemical and Biophysical Research Communications\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">554\u003C/span>, 94–98. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+protein+interactions+with+amyloidogenic+proteins:+Potential+clues+to+neurodegeneration&author=Idrees,+D.&author=Kumar,+V.&publication_year=2021&journal=Biochemical+and+Biophysical+Research+Communications&volume=554&pages=94%E2%80%9398&doi=10.1016/j.bbrc.2021.03.100&pmid=33789211\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.bbrc.2021.03.100\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33789211\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B52-preprints-107672\" class=\"html-xx\" data-content=\"52.\">Charnley, M.; Islam, S.; Bindra, G. K.; Engwirda, J.; Ratcliffe, J.; Zhou, J.; Mezzenga, R.; Hulett, M. D.; Han, K.; Berryman, J. T.; Reynolds, N. P. , Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19. \u003Cspan class=\"html-italic\">Nature Communications\u003C/span> \u003Cb>2022\u003C/b>, 13. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Neurotoxic+amyloidogenic+peptides+in+the+proteome+of+SARS-COV2:+potential+implications+for+neurological+symptoms+in+COVID-19&author=Charnley,+M.&author=Islam,+S.&author=Bindra,+G.+K.&author=Engwirda,+J.&author=Ratcliffe,+J.&author=Zhou,+J.&author=Mezzenga,+R.&author=Hulett,+M.+D.&author=Han,+K.&author=Berryman,+J.+T.&publication_year=2022&journal=Nature+Communications&pages=13&doi=10.1038/s41467-022-30932-1\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41467-022-30932-1\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B53-preprints-107672\" class=\"html-xx\" data-content=\"53.\">Kruger, A.; Vlok, M.; Turner, S.; Venter, C.; Laubscher, G. J.; Kell, D. B.; Pretorius, E. , Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system. \u003Cspan class=\"html-italic\">Cardiovascular Diabetology\u003C/span> \u003Cb>2022\u003C/b>, 21. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Proteomics+of+fibrin+amyloid+microclots+in+long+COVID/post-acute+sequelae+of+COVID-19+(PASC)+shows+many+entrapped+pro-inflammatory+molecules+that+may+also+contribute+to+a+failed+fibrinolytic+system&author=Kruger,+A.&author=Vlok,+M.&author=Turner,+S.&author=Venter,+C.&author=Laubscher,+G.+J.&author=Kell,+D.+B.&author=Pretorius,+E.&publication_year=2022&journal=Cardiovascular+Diabetology&pages=21&doi=10.1186/s12933-022-01623-4&pmid=36131342\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1186/s12933-022-01623-4\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36131342\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B54-preprints-107672\" class=\"html-xx\" data-content=\"54.\">Nyström, S.; Hammarström, P. , Amyloidogenesis of SARS-CoV-2 Spike Protein. \u003Cspan class=\"html-italic\">Journal of the American Chemical Society\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">144\u003C/span>, 8945–50. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Amyloidogenesis+of+SARS-CoV-2+Spike+Protein&author=Nystr%C3%B6m,+S.&author=Hammarstr%C3%B6m,+P.&publication_year=2022&journal=Journal+of+the+American+Chemical+Society&volume=144&pages=8945%E2%80%9350&doi=10.1021/jacs.2c03925\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1021/jacs.2c03925\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B55-preprints-107672\" class=\"html-xx\" data-content=\"55.\">Chesney, A. D.; Maiti, B.; Hansmann, U. H. E. , SARS-COV-2 spike protein fragment eases amyloidogenesis of alpha-synuclein. \u003Cspan class=\"html-italic\">J Chem Phys\u003C/span> \u003Cb>2023\u003C/b>, 159. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-COV-2+spike+protein+fragment+eases+amyloidogenesis+of+alpha-synuclein&author=Chesney,+A.+D.&author=Maiti,+B.&author=Hansmann,+U.+H.+E.&publication_year=2023&journal=J+Chem+Phys&pages=159\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>]\u003C/li>\n\u003Cli id=\"B56-preprints-107672\" class=\"html-xx\" data-content=\"56.\">Olajide, O. A.; Iwuanyanwu, V. U.; Adegbola, O. D.; Al-Hindawi, A. A. , SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia. \u003Cspan class=\"html-italic\">Molecular Neurobiology\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">59\u003C/span>, 445–58. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Spike+Glycoprotein+S1+Induces+Neuroinflammation+in+BV-2+Microglia&author=Olajide,+O.+A.&author=Iwuanyanwu,+V.+U.&author=Adegbola,+O.+D.&author=Al-Hindawi,+A.+A.&publication_year=2021&journal=Molecular+Neurobiology&volume=59&pages=445%E2%80%9358&doi=10.1007/s12035-021-02593-6\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1007/s12035-021-02593-6\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B57-preprints-107672\" class=\"html-xx\" data-content=\"57.\">Oh, J.; Cho, W.-H.; Barcelon, E.; Kim, K. H.; Hong, J.; Lee, S. J. , SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. \u003Cspan class=\"html-italic\">Scientific Reports\u003C/span> \u003Cb>2022\u003C/b>, 12. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+protein+induces+cognitive+deficit+and+anxiety-like+behavior+in+mouse+via+non-cell+autonomous+hippocampal+neuronal+death&author=Oh,+J.&author=Cho,+W.-H.&author=Barcelon,+E.&author=Kim,+K.+H.&author=Hong,+J.&author=Lee,+S.+J.&publication_year=2022&journal=Scientific+Reports&pages=12&doi=10.1038/s41598-022-09410-7&pmid=35361832\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41598-022-09410-7\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35361832\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B58-preprints-107672\" class=\"html-xx\" data-content=\"58.\">O'Brien, B. C. V.; Weber, L.; Hueffer, K.; Weltzin, M. M. , SARS-CoV-2 spike ectodomain targets alpha7 nicotinic acetylcholine receptors. \u003Cspan class=\"html-italic\">J Biol Chem\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">299\u003C/span>, 104707. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+spike+ectodomain+targets+alpha7+nicotinic+acetylcholine+receptors&author=O'Brien,+B.+C.+V.&author=Weber,+L.&author=Hueffer,+K.&author=Weltzin,+M.+M.&publication_year=2023&journal=J+Biol+Chem&volume=299&pages=104707\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>]\u003C/li>\n\u003Cli id=\"B59-preprints-107672\" class=\"html-xx\" data-content=\"59.\">Buzhdygan, T. P.; DeOre, B. J.; Baldwin-Leclair, A.; Bullock, T. A.; McGary, H. M.; Khan, J. A.; Razmpour, R.; Hale, J. F.; Galie, P. A.; Potula, R.; Andrews, A. M.; Ramirez, S. H. , The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier. \u003Cspan class=\"html-italic\">Neurobiol Dis\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">146\u003C/span>, 105131. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+SARS-CoV-2+spike+protein+alters+barrier+function+in+2D+static+and+3D+microfluidic+in-vitro+models+of+the+human+blood-brain+barrier&author=Buzhdygan,+T.+P.&author=DeOre,+B.+J.&author=Baldwin-Leclair,+A.&author=Bullock,+T.+A.&author=McGary,+H.+M.&author=Khan,+J.+A.&author=Razmpour,+R.&author=Hale,+J.+F.&author=Galie,+P.+A.&author=Potula,+R.&publication_year=2020&journal=Neurobiol+Dis&volume=146&pages=105131&doi=10.1016/j.nbd.2020.105131\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.nbd.2020.105131\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B60-preprints-107672\" class=\"html-xx\" data-content=\"60.\">Rhea, E. M.; Logsdon, A. F.; Hansen, K. M.; Williams, L. M.; Reed, M. J.; Baumann, K. K.; Holden, S. J.; Raber, J.; Banks, W. A.; Erickson, M. A. , The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice. \u003Cspan class=\"html-italic\">Nature Neuroscience\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">24\u003C/span>, 368–78. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+S1+protein+of+SARS-CoV-2+crosses+the+blood%E2%80%93brain+barrier+in+mice&author=Rhea,+E.+M.&author=Logsdon,+A.+F.&author=Hansen,+K.+M.&author=Williams,+L.+M.&author=Reed,+M.+J.&author=Baumann,+K.+K.&author=Holden,+S.+J.&author=Raber,+J.&author=Banks,+W.+A.&author=Erickson,+M.+A.&publication_year=2020&journal=Nature+Neuroscience&volume=24&pages=368%E2%80%9378&doi=10.1038/s41593-020-00771-8\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41593-020-00771-8\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B61-preprints-107672\" class=\"html-xx\" data-content=\"61.\">Zhang, L.; Zhou, L.; Bao, L.; Liu, J.; Zhu, H.; Lv, Q.; Liu, R.; Chen, W.; Tong, W.; Wei, Q.; Xu, Y.; Deng, W.; Gao, H.; Xue, J.; Song, Z.; Yu, P.; Han, Y.; Zhang, Y.; Sun, X.; Yu, X.; Qin, C. , SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration. \u003Cspan class=\"html-italic\">Signal Transduction and Targeted Therapy\u003C/span> \u003Cb>2021\u003C/b>, 6. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+crosses+the+blood%E2%80%93brain+barrier+accompanied+with+basement+membrane+disruption+without+tight+junctions+alteration&author=Zhang,+L.&author=Zhou,+L.&author=Bao,+L.&author=Liu,+J.&author=Zhu,+H.&author=Lv,+Q.&author=Liu,+R.&author=Chen,+W.&author=Tong,+W.&author=Wei,+Q.&publication_year=2021&journal=Signal+Transduction+and+Targeted+Therapy&pages=6&doi=10.1038/s41392-021-00719-9\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41392-021-00719-9\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B62-preprints-107672\" class=\"html-xx\" data-content=\"62.\">Trougakos, I. P.; Terpos, E.; Alexopoulos, H.; Politou, M.; Paraskevis, D.; Scorilas, A.; Kastritis, E.; Andreakos, E.; Dimopoulos, M. A. , Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis. \u003Cspan class=\"html-italic\">Trends in Molecular Medicine\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">28\u003C/span>, 542–54. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Adverse+effects+of+COVID-19+mRNA+vaccines:+the+spike+hypothesis&author=Trougakos,+I.+P.&author=Terpos,+E.&author=Alexopoulos,+H.&author=Politou,+M.&author=Paraskevis,+D.&author=Scorilas,+A.&author=Kastritis,+E.&author=Andreakos,+E.&author=Dimopoulos,+M.+A.&publication_year=2022&journal=Trends+in+Molecular+Medicine&volume=28&pages=542%E2%80%9354&doi=10.1016/j.molmed.2022.04.007&pmid=35537987\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.molmed.2022.04.007\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35537987\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B63-preprints-107672\" class=\"html-xx\" data-content=\"63.\">Halma, M. T. J.; Plothe, C.; Marik, P.; Lawrie, T. A. , Strategies for the Management of Spike Protein-Related Pathology. \u003Cspan class=\"html-italic\">Microorganisms\u003C/span> \u003Cb>2023\u003C/b>, 11. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Strategies+for+the+Management+of+Spike+Protein-Related+Pathology&author=Halma,+M.+T.+J.&author=Plothe,+C.&author=Marik,+P.&author=Lawrie,+T.+A.&publication_year=2023&journal=Microorganisms&pages=11&doi=10.3390/microorganisms11051308&pmid=37317282\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/microorganisms11051308\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/37317282\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B64-preprints-107672\" class=\"html-xx\" data-content=\"64.\">Monge, S.; Pastor-Barriuso, R.; Hernán, M. A. , The imprinting effect of covid-19 vaccines: an expected selection bias in observational studies. \u003Cspan class=\"html-italic\">Bmj\u003C/span> \u003Cb>2023\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+imprinting+effect+of+covid-19+vaccines:+an+expected+selection+bias+in+observational+studies&author=Monge,+S.&author=Pastor-Barriuso,+R.&author=Hern%C3%A1n,+M.+A.&publication_year=2023&journal=Bmj&doi=10.1136/bmj-2022-074404\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1136/bmj-2022-074404\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B65-preprints-107672\" class=\"html-xx\" data-content=\"65.\">Wang, Q.; Guo, Y.; Tam, A. R.; Valdez, R.; Gordon, A.; Liu, L.; Ho, D. D. , Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine. \u003Cspan class=\"html-italic\">Cell Rep Med\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">4\u003C/span>, 101258. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Deep+immunological+imprinting+due+to+the+ancestral+spike+in+the+current+bivalent+COVID-19+vaccine&author=Wang,+Q.&author=Guo,+Y.&author=Tam,+A.+R.&author=Valdez,+R.&author=Gordon,+A.&author=Liu,+L.&author=Ho,+D.+D.&publication_year=2023&journal=Cell+Rep+Med&volume=4&pages=101258&doi=10.1016/j.xcrm.2023.101258\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.xcrm.2023.101258\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B66-preprints-107672\" class=\"html-xx\" data-content=\"66.\">Tortorici, M. A.; Addetia, A.; Seo, A. J.; Brown, J.; Sprouse, K.; Logue, J.; Clark, E.; Franko, N.; Chu, H.; Veesler, D. , Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans. \u003Cspan class=\"html-italic\">Immunity 2024, 57, (4), 904-11 e4\u003C/span>.\u003C/li>\n\u003Cli id=\"B67-preprints-107672\" class=\"html-xx\" data-content=\"67.\">Pusnik, J.; Zorn, J.; Monzon-Posadas, W. O.; Peters, K.; Osypchuk, E.; Blaschke, S.; Streeck, H. , Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin. \u003Cspan class=\"html-italic\">Nat Commun\u003C/span> \u003Cb>2024\u003C/b>, \u003Cspan class=\"html-italic\">15\u003C/span>, 3102. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Vaccination+impairs+de+novo+immune+response+to+omicron+breakthrough+infection,+a+precondition+for+the+original+antigenic+sin&author=Pusnik,+J.&author=Zorn,+J.&author=Monzon-Posadas,+W.+O.&author=Peters,+K.&author=Osypchuk,+E.&author=Blaschke,+S.&author=Streeck,+H.&publication_year=2024&journal=Nat+Commun&volume=15&pages=3102&doi=10.1038/s41467-024-47451-w\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41467-024-47451-w\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B68-preprints-107672\" class=\"html-xx\" data-content=\"68.\">Shrestha, N. K.; Burke, P. C.; Nowacki, A. S.; Simon, J. F.; Hagen, A.; Gordon, S. M. , Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine. \u003Cspan class=\"html-italic\">Open Forum Infectious Diseases\u003C/span> \u003Cb>2023\u003C/b>, 10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Effectiveness+of+the+Coronavirus+Disease+2019+Bivalent+Vaccine&author=Shrestha,+N.+K.&author=Burke,+P.+C.&author=Nowacki,+A.+S.&author=Simon,+J.+F.&author=Hagen,+A.&author=Gordon,+S.+M.&publication_year=2023&journal=Open+Forum+Infectious+Diseases&pages=10&doi=10.1093/ofid/ofad209\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1093/ofid/ofad209\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B69-preprints-107672\" class=\"html-xx\" data-content=\"69.\">Arvin, A. M.; Fink, K.; Schmid, M. A.; Cathcart, A.; Spreafico, R.; Havenar-Daughton, C.; Lanzavecchia, A.; Corti, D.; Virgin, H. W. , A perspective on potential antibody-dependent enhancement of SARS-CoV-2. \u003Cspan class=\"html-italic\">Nature\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">584\u003C/span>, 353–63. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+A+perspective+on+potential+antibody-dependent+enhancement+of+SARS-CoV-2&author=Arvin,+A.+M.&author=Fink,+K.&author=Schmid,+M.+A.&author=Cathcart,+A.&author=Spreafico,+R.&author=Havenar-Daughton,+C.&author=Lanzavecchia,+A.&author=Corti,+D.&author=Virgin,+H.+W.&publication_year=2020&journal=Nature&volume=584&pages=353%E2%80%9363&doi=10.1038/s41586-020-2538-8\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41586-020-2538-8\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B70-preprints-107672\" class=\"html-xx\" data-content=\"70.\">Lee, W. S.; Wheatley, A. K.; Kent, S. J.; DeKosky, B. J. , Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies. \u003Cspan class=\"html-italic\">Nat Microbiol\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">5\u003C/span>, 1185–91. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Antibody-dependent+enhancement+and+SARS-CoV-2+vaccines+and+therapies&author=Lee,+W.+S.&author=Wheatley,+A.+K.&author=Kent,+S.+J.&author=DeKosky,+B.+J.&publication_year=2020&journal=Nat+Microbiol&volume=5&pages=1185%E2%80%9391&doi=10.1038/s41564-020-00789-5\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41564-020-00789-5\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B71-preprints-107672\" class=\"html-xx\" data-content=\"71.\">Irrgang, P.; Gerling, J.; Kocher, K.; Lapuente, D.; Steininger, P.; Habenicht, K.; Wytopil, M.; Beileke, S.; Schäfer, S.; Zhong, J.; Ssebyatika, G.; Krey, T.; Falcone, V.; Schülein, C.; Peter, A. S.; Nganou-Makamdop, K.; Hengel, H.; Held, J.; Bogdan, C.; Überla, K.; Schober, K.; Winkler, T. H.; Tenbusch, M. , Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. \u003Cspan class=\"html-italic\">Science Immunology\u003C/span> \u003Cb>2023\u003C/b>, 8. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Class+switch+toward+noninflammatory,+spike-specific+IgG4+antibodies+after+repeated+SARS-CoV-2+mRNA+vaccination&author=Irrgang,+P.&author=Gerling,+J.&author=Kocher,+K.&author=Lapuente,+D.&author=Steininger,+P.&author=Habenicht,+K.&author=Wytopil,+M.&author=Beileke,+S.&author=Sch%C3%A4fer,+S.&author=Zhong,+J.&publication_year=2023&journal=Science+Immunology&pages=8&doi=10.1126/sciimmunol.ade2798\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1126/sciimmunol.ade2798\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B72-preprints-107672\" class=\"html-xx\" data-content=\"72.\">Kiszel, P.; Sík, P.; Miklós, J.; Kajdácsi, E.; Sinkovits, G.; Cervenak, L.; Prohászka, Z. , Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. \u003Cspan class=\"html-italic\">Scientific Reports\u003C/span> \u003Cb>2023\u003C/b>, 13. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Class+switch+towards+spike+protein-specific+IgG4+antibodies+after+SARS-CoV-2+mRNA+vaccination+depends+on+prior+infection+history&author=Kiszel,+P.&author=S%C3%ADk,+P.&author=Mikl%C3%B3s,+J.&author=Kajd%C3%A1csi,+E.&author=Sinkovits,+G.&author=Cervenak,+L.&author=Proh%C3%A1szka,+Z.&publication_year=2023&journal=Scientific+Reports&pages=13&doi=10.1038/s41598-023-40103-x\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41598-023-40103-x\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B73-preprints-107672\" class=\"html-xx\" data-content=\"73.\">Uversky, V.; Redwan, E.; Makis, W.; Rubio-Casillas, A. , IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. \u003Cspan class=\"html-italic\">Vaccines\u003C/span> \u003Cb>2023\u003C/b>, 11. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+IgG4+Antibodies+Induced+by+Repeated+Vaccination+May+Generate+Immune+Tolerance+to+the+SARS-CoV-2+Spike+Protein&author=Uversky,+V.&author=Redwan,+E.&author=Makis,+W.&author=Rubio-Casillas,+A.&publication_year=2023&journal=Vaccines&pages=11&doi=10.3390/vaccines11050991\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/vaccines11050991\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B74-preprints-107672\" class=\"html-xx\" data-content=\"74.\">Yoshimura, M.; Sakamoto, A.; Ozuru, R.; Kurihara, Y.; Itoh, R.; Ishii, K.; Shimizu, A.; Chou, B.; Nabeshima, S.; Hiromatsu, K. , The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines. \u003Cspan class=\"html-italic\">Int J Infect Dis\u003C/span> \u003Cb>2024\u003C/b>, \u003Cspan class=\"html-italic\">139\u003C/span>, 1–5. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+appearance+of+anti-spike+receptor+binding+domain+immunoglobulin+G4+responses+after+repetitive+immunization+with+messenger+RNA-based+COVID-19+vaccines&author=Yoshimura,+M.&author=Sakamoto,+A.&author=Ozuru,+R.&author=Kurihara,+Y.&author=Itoh,+R.&author=Ishii,+K.&author=Shimizu,+A.&author=Chou,+B.&author=Nabeshima,+S.&author=Hiromatsu,+K.&publication_year=2024&journal=Int+J+Infect+Dis&volume=139&pages=1%E2%80%935&doi=10.1016/j.ijid.2023.11.028\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ijid.2023.11.028\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B75-preprints-107672\" class=\"html-xx\" data-content=\"75.\">Espino, A. M.; Armina-Rodriguez, A.; Alvarez, L.; Ocasio-Malave, C.; Ramos-Nieves, R.; Rodriguez Martino, E. I.; Lopez-Marte, P.; Torres, E. A.; Sariol, C. A. , The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine. \u003Cspan class=\"html-italic\">Viruses\u003C/span> \u003Cb>2024\u003C/b>, 16. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+Anti-SARS-CoV-2+IgG1+and+IgG3+Antibody+Isotypes+with+Limited+Neutralizing+Capacity+against+Omicron+Elicited+in+a+Latin+Population+a+Switch+toward+IgG4+after+Multiple+Doses+with+the+mRNA+Pfizer-BioNTech+Vaccine&author=Espino,+A.+M.&author=Armina-Rodriguez,+A.&author=Alvarez,+L.&author=Ocasio-Malave,+C.&author=Ramos-Nieves,+R.&author=Rodriguez+Martino,+E.+I.&author=Lopez-Marte,+P.&author=Torres,+E.+A.&author=Sariol,+C.+A.&publication_year=2024&journal=Viruses&pages=16&doi=10.3390/v16020187\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/v16020187\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B76-preprints-107672\" class=\"html-xx\" data-content=\"76.\">Rubio-Casillas, A.; Cowley, D.; Raszek, M.; Uversky, V. N.; Redwan, E. M. , Review: N1-methyl-pseudouridine (m1Psi): Friend or foe of cancer? \u003Cspan class=\"html-italic\">Int J Biol Macromol\u003C/span> \u003Cb>2024\u003C/b>, \u003Cspan class=\"html-italic\">(Pt 1)\u003C/span> \u003Cspan class=\"html-italic\">Pt 1\u003C/span>, 131427. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Review:+N1-methyl-pseudouridine+(m1Psi):+Friend+or+foe+of+cancer?&author=Rubio-Casillas,+A.&author=Cowley,+D.&author=Raszek,+M.&author=Uversky,+V.+N.&author=Redwan,+E.+M.&publication_year=2024&journal=Int+J+Biol+Macromol&volume=(Pt+1)&issue=Pt+1&pages=131427&doi=10.1016/j.ijbiomac.2024.131427\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ijbiomac.2024.131427\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B77-preprints-107672\" class=\"html-xx\" data-content=\"77.\">Murata, K.; Nakao, N.; Ishiuchi, N.; Fukui, T.; Katsuya, N.; Fukumoto, W.; Oka, H.; Yoshikawa, N.; Nagao, T.; Namera, A.; Kakimoto, N.; Oue, N.; Awai, K.; Yoshimoto, K.; Nagao, M. , Four cases of cytokine storm after COVID-19 vaccination: Case report. \u003Cspan class=\"html-italic\">Front Immunol\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">13\u003C/span>, 967226. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Four+cases+of+cytokine+storm+after+COVID-19+vaccination:+Case+report&author=Murata,+K.&author=Nakao,+N.&author=Ishiuchi,+N.&author=Fukui,+T.&author=Katsuya,+N.&author=Fukumoto,+W.&author=Oka,+H.&author=Yoshikawa,+N.&author=Nagao,+T.&author=Namera,+A.&publication_year=2022&journal=Front+Immunol&volume=13&pages=967226&doi=10.3389/fimmu.2022.967226\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3389/fimmu.2022.967226\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B78-preprints-107672\" class=\"html-xx\" data-content=\"78.\">Masset, C.; Kervella, D.; Kandel-Aznar, C.; Fantou, A.; Blancho, G.; Hamidou, M. , Relapse of IgG4-related nephritis following mRNA COVID-19 vaccine. \u003Cspan class=\"html-italic\">Kidney International\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">100\u003C/span>, 465–66. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Relapse+of+IgG4-related+nephritis+following+mRNA+COVID-19+vaccine&author=Masset,+C.&author=Kervella,+D.&author=Kandel-Aznar,+C.&author=Fantou,+A.&author=Blancho,+G.&author=Hamidou,+M.&publication_year=2021&journal=Kidney+International&volume=100&pages=465%E2%80%9366&doi=10.1016/j.kint.2021.06.002\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.kint.2021.06.002\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B79-preprints-107672\" class=\"html-xx\" data-content=\"79.\">Patel, A. H. , Acute Liver Injury and IgG4-related Autoimmune Pancreatitis following mRNA based COVID-19 vaccination. \u003Cspan class=\"html-italic\">Hepatology Forum\u003C/span> \u003Cb>2022\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Acute+Liver+Injury+and+IgG4-related+Autoimmune+Pancreatitis+following+mRNA+based+COVID-19+vaccination&author=Patel,+A.+H.&publication_year=2022&journal=Hepatology+Forum&doi=10.14744/hf.2022.2022.0019\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.14744/hf.2022.2022.0019\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B80-preprints-107672\" class=\"html-xx\" data-content=\"80.\">Aochi, S.; Uehara, M.; Yamamoto, M. , IgG4-related Disease Emerging after COVID-19 mRNA Vaccination. \u003Cspan class=\"html-italic\">Internal Medicine\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">62\u003C/span>, 1547–51. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+IgG4-related+Disease+Emerging+after+COVID-19+mRNA+Vaccination&author=Aochi,+S.&author=Uehara,+M.&author=Yamamoto,+M.&publication_year=2023&journal=Internal+Medicine&volume=62&pages=1547%E2%80%9351&doi=10.2169/internalmedicine.1125-22\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.2169/internalmedicine.1125-22\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B81-preprints-107672\" class=\"html-xx\" data-content=\"81.\">Katsikas Triantafyllidis, K.; Giannos, P.; Mian, I. T.; Kyrtsonis, G.; Kechagias, K. S. , Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports. \u003Cspan class=\"html-italic\">Vaccines\u003C/span> \u003Cb>2021\u003C/b>, 9. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Varicella+Zoster+Virus+Reactivation+Following+COVID-19+Vaccination:+A+Systematic+Review+of+Case+Reports&author=Katsikas+Triantafyllidis,+K.&author=Giannos,+P.&author=Mian,+I.+T.&author=Kyrtsonis,+G.&author=Kechagias,+K.+S.&publication_year=2021&journal=Vaccines&pages=9&doi=10.3390/vaccines9091013\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/vaccines9091013\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B82-preprints-107672\" class=\"html-xx\" data-content=\"82.\">Lensen, R.; Netea, M. G.; Rosendaal, F. R. , Hepatitis C Virus Reactivation Following COVID-19 Vaccination - A Case Report. \u003Cspan class=\"html-italic\">Int Med Case Rep J\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">14\u003C/span>, 573–76. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Hepatitis+C+Virus+Reactivation+Following+COVID-19+Vaccination+-+A+Case+Report&author=Lensen,+R.&author=Netea,+M.+G.&author=Rosendaal,+F.+R.&publication_year=2021&journal=Int+Med+Case+Rep+J&volume=14&pages=573%E2%80%9376\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>]\u003C/li>\n\u003Cli id=\"B83-preprints-107672\" class=\"html-xx\" data-content=\"83.\">Psichogiou, M.; Samarkos, M.; Mikos, N.; Hatzakis, A. , Reactivation of Varicella Zoster Virus after Vaccination for SARS-CoV-2. \u003Cspan class=\"html-italic\">Vaccines\u003C/span> \u003Cb>2021\u003C/b>, 9. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Reactivation+of+Varicella+Zoster+Virus+after+Vaccination+for+SARS-CoV-2&author=Psichogiou,+M.&author=Samarkos,+M.&author=Mikos,+N.&author=Hatzakis,+A.&publication_year=2021&journal=Vaccines&pages=9&doi=10.3390/vaccines9060572\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/vaccines9060572\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B84-preprints-107672\" class=\"html-xx\" data-content=\"84.\">Fathy, R. A.; McMahon, D. E.; Lee, C.; Chamberlin, G. C.; Rosenbach, M.; Lipoff, J. B.; Tyagi, A.; Desai, S. R.; French, L. E.; Lim, H. W.; Thiers, B. H.; Hruza, G. J.; Fassett, M.; Fox, L. P.; Greenberg, H. L.; Blumenthal, K.; Freeman, E. E. , Varicella-zoster and herpes simplex virus reactivation post-COVID-19 vaccination: a review of 40 cases in an International Dermatology Registry. \u003Cspan class=\"html-italic\">J Eur Acad Dermatol Venereol\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">36\u003C/span>, e6–e9. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Varicella-zoster+and+herpes+simplex+virus+reactivation+post-COVID-19+vaccination:+a+review+of+40+cases+in+an+International+Dermatology+Registry&author=Fathy,+R.+A.&author=McMahon,+D.+E.&author=Lee,+C.&author=Chamberlin,+G.+C.&author=Rosenbach,+M.&author=Lipoff,+J.+B.&author=Tyagi,+A.&author=Desai,+S.+R.&author=French,+L.+E.&author=Lim,+H.+W.&publication_year=2022&journal=J+Eur+Acad+Dermatol+Venereol&volume=36&pages=e6%E2%80%93e9&doi=10.1111/jdv.17646\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/jdv.17646\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B85-preprints-107672\" class=\"html-xx\" data-content=\"85.\">Gringeri, M.; Battini, V.; Cammarata, G.; Mosini, G.; Guarnieri, G.; Leoni, C.; Pozzi, M.; Radice, S.; Clementi, E.; Carnovale, C. , Herpes zoster and simplex reactivation following COVID-19 vaccination: new insights from a vaccine adverse event reporting system (VAERS) database analysis. \u003Cspan class=\"html-italic\">Expert Rev Vaccines\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">21\u003C/span>, 675–84. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Herpes+zoster+and+simplex+reactivation+following+COVID-19+vaccination:+new+insights+from+a+vaccine+adverse+event+reporting+system+(VAERS)+database+analysis&author=Gringeri,+M.&author=Battini,+V.&author=Cammarata,+G.&author=Mosini,+G.&author=Guarnieri,+G.&author=Leoni,+C.&author=Pozzi,+M.&author=Radice,+S.&author=Clementi,+E.&author=Carnovale,+C.&publication_year=2022&journal=Expert+Rev+Vaccines&volume=21&pages=675%E2%80%9384&doi=10.1080/14760584.2022.2044799\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1080/14760584.2022.2044799\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B86-preprints-107672\" class=\"html-xx\" data-content=\"86.\">Hertel, M.; Heiland, M.; Nahles, S.; von Laffert, M.; Mura, C.; Bourne, P. E.; Preissner, R.; Preissner, S. , Real-world evidence from over one million COVID-19 vaccinations is consistent with reactivation of the varicella-zoster virus. \u003Cspan class=\"html-italic\">Journal of the European Academy of Dermatology and Venereology\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">36\u003C/span>, 1342–48. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Real-world+evidence+from+over+one+million+COVID-19+vaccinations+is+consistent+with+reactivation+of+the+varicella-zoster+virus&author=Hertel,+M.&author=Heiland,+M.&author=Nahles,+S.&author=von+Laffert,+M.&author=Mura,+C.&author=Bourne,+P.+E.&author=Preissner,+R.&author=Preissner,+S.&publication_year=2022&journal=Journal+of+the+European+Academy+of+Dermatology+and+Venereology&volume=36&pages=1342%E2%80%9348&doi=10.1111/jdv.18184\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/jdv.18184\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B87-preprints-107672\" class=\"html-xx\" data-content=\"87.\">Shafiee, A.; Amini, M. J.; Arabzadeh Bahri, R.; Jafarabady, K.; Salehi, S. A.; Hajishah, H.; Mozhgani, S.-H. , Herpesviruses reactivation following COVID-19 vaccination: a systematic review and meta-analysis. \u003Cspan class=\"html-italic\">European Journal of Medical Research\u003C/span> \u003Cb>2023\u003C/b>, 28. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Herpesviruses+reactivation+following+COVID-19+vaccination:+a+systematic+review+and+meta-analysis&author=Shafiee,+A.&author=Amini,+M.+J.&author=Arabzadeh+Bahri,+R.&author=Jafarabady,+K.&author=Salehi,+S.+A.&author=Hajishah,+H.&author=Mozhgani,+S.-H.&publication_year=2023&journal=European+Journal+of+Medical+Research&pages=28&doi=10.1186/s40001-023-01238-9\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1186/s40001-023-01238-9\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B88-preprints-107672\" class=\"html-xx\" data-content=\"88.\">Culver, J. , Preventing transmission of blood-borne pathogens: a compelling argument for effective device-selection strategies. \u003Cspan class=\"html-italic\">Am J Infect Control\u003C/span> \u003Cb>1997\u003C/b>, \u003Cspan class=\"html-italic\">25\u003C/span>, 430–3. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Preventing+transmission+of+blood-borne+pathogens:+a+compelling+argument+for+effective+device-selection+strategies&author=Culver,+J.&publication_year=1997&journal=Am+J+Infect+Control&volume=25&pages=430%E2%80%933&doi=10.1016/S0196-6553(97)90094-8&pmid=9343630\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/S0196-6553(97)90094-8\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/9343630\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B89-preprints-107672\" class=\"html-xx\" data-content=\"89.\">Beltrami, E. M.; Williams, I. T.; Shapiro, C. N.; Chamberland, M. E. , Risk and Management of Blood-Borne Infections in Health Care Workers. \u003Cspan class=\"html-italic\">Clinical Microbiology Reviews\u003C/span> \u003Cb>2000\u003C/b>, \u003Cspan class=\"html-italic\">13\u003C/span>, 385–407. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Risk+and+Management+of+Blood-Borne+Infections+in+Health+Care+Workers&author=Beltrami,+E.+M.&author=Williams,+I.+T.&author=Shapiro,+C.+N.&author=Chamberland,+M.+E.&publication_year=2000&journal=Clinical+Microbiology+Reviews&volume=13&pages=385%E2%80%93407&doi=10.1128/CMR.13.3.385\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1128/CMR.13.3.385\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B90-preprints-107672\" class=\"html-xx\" data-content=\"90.\">Ison, M. G.; Grossi, P.; Practice, A. S. T. I. D. C. o. , Donor-derived infections in solid organ transplantation. \u003Cspan class=\"html-italic\">Am J Transplant\u003C/span> \u003Cb>2013\u003C/b>, \u003Cspan class=\"html-italic\">13 Suppl 4\u003C/span>, 22–30. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Donor-derived+infections+in+solid+organ+transplantation&author=Ison,+M.+G.&author=Grossi,+P.&author=Practice,+A.+S.+T.+I.+D.+C.+o.&publication_year=2013&journal=Am+J+Transplant&volume=13+Suppl+4&pages=22%E2%80%9330&doi=10.1111/ajt.12095\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/ajt.12095\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B91-preprints-107672\" class=\"html-xx\" data-content=\"91.\">Fishman, J. A.; Grossi, P. A. , Donor-derived infection--the challenge for transplant safety. \u003Cspan class=\"html-italic\">Nat Rev Nephrol\u003C/span> \u003Cb>2014\u003C/b>, \u003Cspan class=\"html-italic\">10\u003C/span>, 663–72. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Donor-derived+infection--the+challenge+for+transplant+safety&author=Fishman,+J.+A.&author=Grossi,+P.+A.&publication_year=2014&journal=Nat+Rev+Nephrol&volume=10&pages=663%E2%80%9372&doi=10.1038/nrneph.2014.159\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/nrneph.2014.159\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B92-preprints-107672\" class=\"html-xx\" data-content=\"92.\">Bahakel, H. K.; Pellet Madan, R.; Danziger-Isakov, L. , Approach to suspected donor-derived infections. \u003Cspan class=\"html-italic\">Front Pediatr\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">11\u003C/span>, 1265023. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Approach+to+suspected+donor-derived+infections&author=Bahakel,+H.+K.&author=Pellet+Madan,+R.&author=Danziger-Isakov,+L.&publication_year=2023&journal=Front+Pediatr&volume=11&pages=1265023&doi=10.3389/fped.2023.1265023\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3389/fped.2023.1265023\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B93-preprints-107672\" class=\"html-xx\" data-content=\"93.\">Tobin, G. J.; Trujillo, J. D.; Bushnell, R. V.; Lin, G.; Chaudhuri, A. R.; Long, J.; Barrera, J.; Pena, L.; Grubman, M. J.; Nara, P. L. , Deceptive imprinting and immune refocusing in vaccine design. \u003Cspan class=\"html-italic\">Vaccine\u003C/span> \u003Cb>2008\u003C/b>, \u003Cspan class=\"html-italic\">26\u003C/span>, 6189–99. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Deceptive+imprinting+and+immune+refocusing+in+vaccine+design&author=Tobin,+G.+J.&author=Trujillo,+J.+D.&author=Bushnell,+R.+V.&author=Lin,+G.&author=Chaudhuri,+A.+R.&author=Long,+J.&author=Barrera,+J.&author=Pena,+L.&author=Grubman,+M.+J.&author=Nara,+P.+L.&publication_year=2008&journal=Vaccine&volume=26&pages=6189%E2%80%9399&doi=10.1016/j.vaccine.2008.09.080\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.vaccine.2008.09.080\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B94-preprints-107672\" class=\"html-xx\" data-content=\"94.\">Gatto, D.; Brink, R. , The germinal center reaction. \u003Cspan class=\"html-italic\">J Allergy Clin Immunol 2010, 126, (5), 898-907; quiz 08-9\u003C/span>.\u003C/li>\n\u003Cli id=\"B95-preprints-107672\" class=\"html-xx\" data-content=\"95.\">Seneff, S.; Nigh, G. , Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19. \u003Cspan class=\"html-italic\">International Journal of Vaccine Theory, Practice, and Research 2021, 2, (1), 38-79\u003C/span>.\u003C/li>\n\u003Cli id=\"B96-preprints-107672\" class=\"html-xx\" data-content=\"96.\">Bernardini, A.; Gigli, G. L.; Janes, F.; Pellitteri, G.; Ciardi, C.; Fabris, M.; Valente, M. , Creutzfeldt-Jakob disease after COVID-19: infection-induced prion protein misfolding? A case report. \u003Cspan class=\"html-italic\">Prion\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">16\u003C/span>, 78–83. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Creutzfeldt-Jakob+disease+after+COVID-19:+infection-induced+prion+protein+misfolding?+A+case+report&author=Bernardini,+A.&author=Gigli,+G.+L.&author=Janes,+F.&author=Pellitteri,+G.&author=Ciardi,+C.&author=Fabris,+M.&author=Valente,+M.&publication_year=2022&journal=Prion&volume=16&pages=78%E2%80%9383&doi=10.1080/19336896.2022.2095185\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1080/19336896.2022.2095185\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B97-preprints-107672\" class=\"html-xx\" data-content=\"97.\">Lukiw, W. J.; Jaber, V. R.; Pogue, A. I.; Zhao, Y. , SARS-CoV-2 Invasion and Pathological Links to Prion Disease. \u003Cspan class=\"html-italic\">Biomolecules\u003C/span> \u003Cb>2022\u003C/b>, 12. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+SARS-CoV-2+Invasion+and+Pathological+Links+to+Prion+Disease&author=Lukiw,+W.+J.&author=Jaber,+V.+R.&author=Pogue,+A.+I.&author=Zhao,+Y.&publication_year=2022&journal=Biomolecules&pages=12&doi=10.3390/biom12091253\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/biom12091253\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B98-preprints-107672\" class=\"html-xx\" data-content=\"98.\">Tetz, G.; Tetz, V. , Prion-like Domains in Spike Protein of SARS-CoV-2 Differ across Its Variants and Enable Changes in Affinity to ACE2. \u003Cspan class=\"html-italic\">Microorganisms\u003C/span> \u003Cb>2022\u003C/b>, 10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Prion-like+Domains+in+Spike+Protein+of+SARS-CoV-2+Differ+across+Its+Variants+and+Enable+Changes+in+Affinity+to+ACE2&author=Tetz,+G.&author=Tetz,+V.&publication_year=2022&journal=Microorganisms&pages=10&doi=10.3390/microorganisms10020280\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/microorganisms10020280\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B99-preprints-107672\" class=\"html-xx\" data-content=\"99.\">Makhoul, K.; Beeber, T.; Cordero, R.; Khan, A.; Saliaj, M. , Prion Disease After COVID-19: A Case Report. \u003Cspan class=\"html-italic\">Am J Case Rep\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">24\u003C/span>, e940564. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Prion+Disease+After+COVID-19:+A+Case+Report&author=Makhoul,+K.&author=Beeber,+T.&author=Cordero,+R.&author=Khan,+A.&author=Saliaj,+M.&publication_year=2023&journal=Am+J+Case+Rep&volume=24&pages=e940564&doi=10.12659/AJCR.940564&pmid=37731242\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.12659/AJCR.940564\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/37731242\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B100-preprints-107672\" class=\"html-xxx\" data-content=\"100.\">Perez, J.-C.; Moret-Chalmin, C.; Montagnier, L. , Emergence of a New Creutzfeldt-Jakob Disease: 26 Cases of the Human Version of Mad-Cow Disease, Days After a COVID-19 Injection. \u003Cspan class=\"html-italic\">International Journal of Vaccine Theory, Practice, and Research 2023, 3, (1), 727-70\u003C/span>.\u003C/li>\n\u003Cli id=\"B101-preprints-107672\" class=\"html-xxx\" data-content=\"101.\">Seneff, S.; Kyriakopoulos, A. M.; Nigh, G.; McCullough, P. A. , A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review. \u003Cspan class=\"html-italic\">Cureus\u003C/span> \u003Cb>2023\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+A+Potential+Role+of+the+Spike+Protein+in+Neurodegenerative+Diseases:+A+Narrative+Review&author=Seneff,+S.&author=Kyriakopoulos,+A.+M.&author=Nigh,+G.&author=McCullough,+P.+A.&publication_year=2023&journal=Cureus&doi=10.7759/cureus.34872&pmid=36788995\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.7759/cureus.34872\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36788995\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B102-preprints-107672\" class=\"html-xxx\" data-content=\"102.\">Perez, J. C.; Lounnas, V.; Montagnier, M. , The Omicron Variant Breaks the Evolutionary Lineage of Sars-Cov2 Variants. \u003Cspan class=\"html-italic\">International Journal of Research -GRANTHAALAYAH 2021, 9, (12), 108-32\u003C/span>.\u003C/li>\n\u003Cli id=\"B103-preprints-107672\" class=\"html-xxx\" data-content=\"103.\">Chapman, C. W., S. , Project risk management: Process, techniques and insight. Wiley: London, UK, 2003.\u003C/li>\n\u003Cli id=\"B104-preprints-107672\" class=\"html-xxx\" data-content=\"104.\">Aven, T. , Risk assessment and risk management: Review of recent advances on their foundation. \u003Cspan class=\"html-italic\">European Journal of Operational Research\u003C/span> \u003Cb>2016\u003C/b>, \u003Cspan class=\"html-italic\">253\u003C/span>, 1–13. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Risk+assessment+and+risk+management:+Review+of+recent+advances+on+their+foundation&author=Aven,+T.&publication_year=2016&journal=European+Journal+of+Operational+Research&volume=253&pages=1%E2%80%9313&doi=10.1016/j.ejor.2015.12.023\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ejor.2015.12.023\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B105-preprints-107672\" class=\"html-xxx\" data-content=\"105.\">Watson, N.; Brandel, J.-P.; Green, A.; Hermann, P.; Ladogana, A.; Lindsay, T.; Mackenzie, J.; Pocchiari, M.; Smith, C.; Zerr, I.; Pal, S. , The importance of ongoing international surveillance for Creutzfeldt–Jakob disease. \u003Cspan class=\"html-italic\">Nature Reviews Neurology\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">17\u003C/span>, 362–79. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+importance+of+ongoing+international+surveillance+for+Creutzfeldt%E2%80%93Jakob+disease&author=Watson,+N.&author=Brandel,+J.-P.&author=Green,+A.&author=Hermann,+P.&author=Ladogana,+A.&author=Lindsay,+T.&author=Mackenzie,+J.&author=Pocchiari,+M.&author=Smith,+C.&author=Zerr,+I.&publication_year=2021&journal=Nature+Reviews+Neurology&volume=17&pages=362%E2%80%9379&doi=10.1038/s41582-021-00488-7&pmid=33972773\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41582-021-00488-7\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33972773\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B106-preprints-107672\" class=\"html-xxx\" data-content=\"106.\">Moghimi, S. M.; Simberg, D. , Pro-inflammatory concerns with lipid nanoparticles. \u003Cspan class=\"html-italic\">Molecular Therapy\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">30\u003C/span>, 2109–10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Pro-inflammatory+concerns+with+lipid+nanoparticles&author=Moghimi,+S.+M.&author=Simberg,+D.&publication_year=2022&journal=Molecular+Therapy&volume=30&pages=2109%E2%80%9310&doi=10.1016/j.ymthe.2022.04.011&pmid=35487214\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ymthe.2022.04.011\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35487214\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B107-preprints-107672\" class=\"html-xxx\" data-content=\"107.\">Tahtinen, S.; Tong, A.-J.; Himmels, P.; Oh, J.; Paler-Martinez, A.; Kim, L.; Wichner, S.; Oei, Y.; McCarron, M. J.; Freund, E. C.; Amir, Z. A.; de la Cruz, C. C.; Haley, B.; Blanchette, C.; Schartner, J. M.; Ye, W.; Yadav, M.; Sahin, U.; Delamarre, L.; Mellman, I. , IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. \u003Cspan class=\"html-italic\">Nature Immunology\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">23\u003C/span>, 532–42. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+IL-1+and+IL-1ra+are+key+regulators+of+the+inflammatory+response+to+RNA+vaccines&author=Tahtinen,+S.&author=Tong,+A.-J.&author=Himmels,+P.&author=Oh,+J.&author=Paler-Martinez,+A.&author=Kim,+L.&author=Wichner,+S.&author=Oei,+Y.&author=McCarron,+M.+J.&author=Freund,+E.+C.&publication_year=2022&journal=Nature+Immunology&volume=23&pages=532%E2%80%9342&doi=10.1038/s41590-022-01160-y&pmid=35332327\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41590-022-01160-y\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35332327\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B108-preprints-107672\" class=\"html-xxx\" data-content=\"108.\">Halma, M. T. J.; Rose, J.; Lawrie, T. , The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review. \u003Cspan class=\"html-italic\">J\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">6\u003C/span>, 220–35. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+Novelty+of+mRNA+Viral+Vaccines+and+Potential+Harms:+A+Scoping+Review&author=Halma,+M.+T.+J.&author=Rose,+J.&author=Lawrie,+T.&publication_year=2023&journal=J&volume=6&pages=220%E2%80%9335&doi=10.3390/j6020017\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/j6020017\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B109-preprints-107672\" class=\"html-xxx\" data-content=\"109.\">Bakos, T.; Meszaros, T.; Kozma, G. T.; Berenyi, P.; Facsko, R.; Farkas, H.; Dezsi, L.; Heirman, C.; de Koker, S.; Schiffelers, R.; Glatter, K. A.; Radovits, T.; Szenasi, G.; Szebeni, J. , mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions. \u003Cspan class=\"html-italic\">Int J Mol Sci\u003C/span> \u003Cb>2024\u003C/b>, 25. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+mRNA-LNP+COVID-19+Vaccine+Lipids+Induce+Complement+Activation+and+Production+of+Proinflammatory+Cytokines:+Mechanisms,+Effects+of+Complement+Inhibitors,+and+Relevance+to+Adverse+Reactions&author=Bakos,+T.&author=Meszaros,+T.&author=Kozma,+G.+T.&author=Berenyi,+P.&author=Facsko,+R.&author=Farkas,+H.&author=Dezsi,+L.&author=Heirman,+C.&author=de+Koker,+S.&author=Schiffelers,+R.&publication_year=2024&journal=Int+J+Mol+Sci&pages=25&doi=10.3390/ijms25073595&pmid=38612407\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/ijms25073595\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/38612407\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B110-preprints-107672\" class=\"html-xxx\" data-content=\"110.\">Moghimi, S. M. , Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. \u003Cspan class=\"html-italic\">Molecular Therapy\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">29\u003C/span>, 898–900. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Allergic+Reactions+and+Anaphylaxis+to+LNP-Based+COVID-19+Vaccines&author=Moghimi,+S.+M.&publication_year=2021&journal=Molecular+Therapy&volume=29&pages=898%E2%80%93900&doi=10.1016/j.ymthe.2021.01.030\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ymthe.2021.01.030\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B111-preprints-107672\" class=\"html-xxx\" data-content=\"111.\">Faizullin, D.; Valiullina, Y.; Salnikov, V.; Zuev, Y. , Direct interaction of fibrinogen with lipid microparticles modulates clotting kinetics and clot structure. \u003Cspan class=\"html-italic\">Nanomedicine\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">23\u003C/span>, 102098. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Direct+interaction+of+fibrinogen+with+lipid+microparticles+modulates+clotting+kinetics+and+clot+structure&author=Faizullin,+D.&author=Valiullina,+Y.&author=Salnikov,+V.&author=Zuev,+Y.&publication_year=2020&journal=Nanomedicine&volume=23&pages=102098&doi=10.1016/j.nano.2019.102098\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.nano.2019.102098\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B112-preprints-107672\" class=\"html-xxx\" data-content=\"112.\">Stark, K.; Massberg, S. , Interplay between inflammation and thrombosis in cardiovascular pathology. \u003Cspan class=\"html-italic\">Nat Rev Cardiol\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">18\u003C/span>, 666–82. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Interplay+between+inflammation+and+thrombosis+in+cardiovascular+pathology&author=Stark,+K.&author=Massberg,+S.&publication_year=2021&journal=Nat+Rev+Cardiol&volume=18&pages=666%E2%80%9382&doi=10.1038/s41569-021-00552-1&pmid=33958774\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41569-021-00552-1\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33958774\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B113-preprints-107672\" class=\"html-xxx\" data-content=\"113.\">Maltezou, H. C.; Pavli, A.; Tsakris, A. , Post-COVID Syndrome: An Insight on Its Pathogenesis. \u003Cspan class=\"html-italic\">Vaccines\u003C/span> \u003Cb>2021\u003C/b>, 9. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Post-COVID+Syndrome:+An+Insight+on+Its+Pathogenesis&author=Maltezou,+H.+C.&author=Pavli,+A.&author=Tsakris,+A.&publication_year=2021&journal=Vaccines&pages=9&doi=10.3390/vaccines9050497&pmid=34066007\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/vaccines9050497\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34066007\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B114-preprints-107672\" class=\"html-xxx\" data-content=\"114.\">Theoharides, T. C. , Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? \u003Cspan class=\"html-italic\">Molecular Neurobiology\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">59\u003C/span>, 1850–61. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Could+SARS-CoV-2+Spike+Protein+Be+Responsible+for+Long-COVID+Syndrome?&author=Theoharides,+T.+C.&publication_year=2022&journal=Molecular+Neurobiology&volume=59&pages=1850%E2%80%9361&doi=10.1007/s12035-021-02696-0&pmid=35028901\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1007/s12035-021-02696-0\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35028901\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B115-preprints-107672\" class=\"html-xxx\" data-content=\"115.\">Greene, C.; Connolly, R.; Brennan, D.; Laffan, A.; O'Keeffe, E.; Zaporojan, L.; O'Callaghan, J.; Thomson, B.; Connolly, E.; Argue, R.; Martin-Loeches, I.; Long, A.; Cheallaigh, C. N.; Conlon, N.; Doherty, C. P.; Campbell, M. , Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment. \u003Cspan class=\"html-italic\">Nat Neurosci\u003C/span> \u003Cb>2024\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Blood-brain+barrier+disruption+and+sustained+systemic+inflammation+in+individuals+with+long+COVID-associated+cognitive+impairment&author=Greene,+C.&author=Connolly,+R.&author=Brennan,+D.&author=Laffan,+A.&author=O'Keeffe,+E.&author=Zaporojan,+L.&author=O'Callaghan,+J.&author=Thomson,+B.&author=Connolly,+E.&author=Argue,+R.&publication_year=2024&journal=Nat+Neurosci\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>]\u003C/li>\n\u003Cli id=\"B116-preprints-107672\" class=\"html-xxx\" data-content=\"116.\">Houston, F.; Foster, J. D.; Chong, A.; Hunter, N.; Bostock, C. J. , Transmission of BSE by blood transfusion in sheep. \u003Cspan class=\"html-italic\">Lancet\u003C/span> \u003Cb>2000\u003C/b>, \u003Cspan class=\"html-italic\">356\u003C/span>, 999–1000. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Transmission+of+BSE+by+blood+transfusion+in+sheep&author=Houston,+F.&author=Foster,+J.+D.&author=Chong,+A.&author=Hunter,+N.&author=Bostock,+C.+J.&publication_year=2000&journal=Lancet&volume=356&pages=999%E2%80%931000&doi=10.1016/S0140-6736(00)02719-7&pmid=11041403\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/S0140-6736(00)02719-7\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/11041403\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B117-preprints-107672\" class=\"html-xxx\" data-content=\"117.\">Hunter, N.; Foster, J.; Chong, A.; McCutcheon, S.; Parnham, D.; Eaton, S.; MacKenzie, C.; Houston, F. , Transmission of prion diseases by blood transfusion. \u003Cspan class=\"html-italic\">J Gen Virol\u003C/span> \u003Cb>2002\u003C/b>, \u003Cspan class=\"html-italic\">(Pt 11)\u003C/span> \u003Cspan class=\"html-italic\">Pt 11\u003C/span>, 2897–905. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Transmission+of+prion+diseases+by+blood+transfusion&author=Hunter,+N.&author=Foster,+J.&author=Chong,+A.&author=McCutcheon,+S.&author=Parnham,+D.&author=Eaton,+S.&author=MacKenzie,+C.&author=Houston,+F.&publication_year=2002&journal=J+Gen+Virol&volume=(Pt+11)&issue=Pt+11&pages=2897%E2%80%93905&doi=10.1099/0022-1317-83-11-2897\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1099/0022-1317-83-11-2897\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B118-preprints-107672\" class=\"html-xxx\" data-content=\"118.\">Seki, Y.; Yamazaki, Y.; Inoue, Y.; Wakabayashi, C.; Seto, S. , How HIV infected haemophiliacs in Japan were informed of their HIV-positive status. \u003Cspan class=\"html-italic\">AIDS Care\u003C/span> \u003Cb>2002\u003C/b>, \u003Cspan class=\"html-italic\">14\u003C/span>, 651–64. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+How+HIV+infected+haemophiliacs+in+Japan+were+informed+of+their+HIV-positive+status&author=Seki,+Y.&author=Yamazaki,+Y.&author=Inoue,+Y.&author=Wakabayashi,+C.&author=Seto,+S.&publication_year=2002&journal=AIDS+Care&volume=14&pages=651%E2%80%9364&doi=10.1080/0954012021000005489&pmid=12419115\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1080/0954012021000005489\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/12419115\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B119-preprints-107672\" class=\"html-xxx\" data-content=\"119.\">Llewelyn, C. A.; Hewitt, P. E.; Knight, R. S.; Amar, K.; Cousens, S.; Mackenzie, J.; Will, R. G. , Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. \u003Cspan class=\"html-italic\">Lancet\u003C/span> \u003Cb>2004\u003C/b>, \u003Cspan class=\"html-italic\">363\u003C/span>, 417–21. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Possible+transmission+of+variant+Creutzfeldt-Jakob+disease+by+blood+transfusion&author=Llewelyn,+C.+A.&author=Hewitt,+P.+E.&author=Knight,+R.+S.&author=Amar,+K.&author=Cousens,+S.&author=Mackenzie,+J.&author=Will,+R.+G.&publication_year=2004&journal=Lancet&volume=363&pages=417%E2%80%9321&doi=10.1016/S0140-6736(04)15486-X&pmid=14962520\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/S0140-6736(04)15486-X\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/14962520\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B120-preprints-107672\" class=\"html-xxx\" data-content=\"120.\">Cullinane, J. , Tainted Blood and Vengeful Spirits: The Legacy of Japan’s Yakugai Eizu (AIDS) Trial. \u003Cspan class=\"html-italic\">Culture, Medicine and Psychiatry 2005, 29, (1), 5-31\u003C/span>.\u003C/li>\n\u003Cli id=\"B121-preprints-107672\" class=\"html-xxx\" data-content=\"121.\">Hewitt, P. E.; Llewelyn, C. A.; Mackenzie, J.; Will, R. G. , Creutzfeldt–Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. \u003Cspan class=\"html-italic\">Vox Sanguinis\u003C/span> \u003Cb>2006\u003C/b>, \u003Cspan class=\"html-italic\">91\u003C/span>, 221–30. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Creutzfeldt%E2%80%93Jakob+disease+and+blood+transfusion:+results+of+the+UK+Transfusion+Medicine+Epidemiological+Review+study&author=Hewitt,+P.+E.&author=Llewelyn,+C.+A.&author=Mackenzie,+J.&author=Will,+R.+G.&publication_year=2006&journal=Vox+Sanguinis&volume=91&pages=221%E2%80%9330&doi=10.1111/j.1423-0410.2006.00833.x\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/j.1423-0410.2006.00833.x\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B122-preprints-107672\" class=\"html-xxx\" data-content=\"122.\">McLeod, N. P.; Nugent, P.; Dixon, D.; Dennis, M.; Cornwall, M.; Mallinson, G.; Watkins, N.; Thomas, S.; Sutton, J. M. , Evaluation of efficacy of prion reduction filters using blood from an endogenously infected 263K scrapie hamster model. \u003Cspan class=\"html-italic\">Transfusion\u003C/span> \u003Cb>2015\u003C/b>, \u003Cspan class=\"html-italic\">55\u003C/span>, 2390–7. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Evaluation+of+efficacy+of+prion+reduction+filters+using+blood+from+an+endogenously+infected+263K+scrapie+hamster+model&author=McLeod,+N.+P.&author=Nugent,+P.&author=Dixon,+D.&author=Dennis,+M.&author=Cornwall,+M.&author=Mallinson,+G.&author=Watkins,+N.&author=Thomas,+S.&author=Sutton,+J.+M.&publication_year=2015&journal=Transfusion&volume=55&pages=2390%E2%80%937&doi=10.1111/trf.13172\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/trf.13172\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B123-preprints-107672\" class=\"html-xxx\" data-content=\"123.\">Seed, C. R.; Hewitt, P. E.; Dodd, R. Y.; Houston, F.; Cervenakova, L. , Creutzfeldt-Jakob disease and blood transfusion safety. \u003Cspan class=\"html-italic\">Vox Sanguinis\u003C/span> \u003Cb>2018\u003C/b>, \u003Cspan class=\"html-italic\">113\u003C/span>, 220–31. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Creutzfeldt-Jakob+disease+and+blood+transfusion+safety&author=Seed,+C.+R.&author=Hewitt,+P.+E.&author=Dodd,+R.+Y.&author=Houston,+F.&author=Cervenakova,+L.&publication_year=2018&journal=Vox+Sanguinis&volume=113&pages=220%E2%80%9331&doi=10.1111/vox.12631&pmid=29359329\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/vox.12631\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/29359329\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B124-preprints-107672\" class=\"html-xxx\" data-content=\"124.\">Tighe, P. J.; Ryder, R. R.; Todd, I.; Fairclough, L. C. , ELISA in the multiplex era: Potentials and pitfalls. \u003Cspan class=\"html-italic\">PROTEOMICS – Clinical Applications 2015, 9, (3-4), 406-22\u003C/span>.\u003C/li>\n\u003Cli id=\"B125-preprints-107672\" class=\"html-xxx\" data-content=\"125.\">Macklin, A.; Khan, S.; Kislinger, T. , Recent advances in mass spectrometry based clinical proteomics: applications to cancer research. \u003Cspan class=\"html-italic\">Clinical Proteomics\u003C/span> \u003Cb>2020\u003C/b>, 17. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Recent+advances+in+mass+spectrometry+based+clinical+proteomics:+applications+to+cancer+research&author=Macklin,+A.&author=Khan,+S.&author=Kislinger,+T.&publication_year=2020&journal=Clinical+Proteomics&pages=17&doi=10.1186/s12014-020-09283-w&pmid=32489335\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1186/s12014-020-09283-w\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/32489335\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B126-preprints-107672\" class=\"html-xxx\" data-content=\"126.\">Wang, D.; Baudys, J.; Bundy, J. L.; Solano, M.; Keppel, T.; Barr, J. R. , Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry. \u003Cspan class=\"html-italic\">Analytical Chemistry\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">92\u003C/span>, 14730–39. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Comprehensive+Analysis+of+the+Glycan+Complement+of+SARS-CoV-2+Spike+Proteins+Using+Signature+Ions-Triggered+Electron-Transfer/Higher-Energy+Collisional+Dissociation+(EThcD)+Mass+Spectrometry&author=Wang,+D.&author=Baudys,+J.&author=Bundy,+J.+L.&author=Solano,+M.&author=Keppel,+T.&author=Barr,+J.+R.&publication_year=2020&journal=Analytical+Chemistry&volume=92&pages=14730%E2%80%9339&doi=10.1021/acs.analchem.0c03301&pmid=33064451\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1021/acs.analchem.0c03301\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33064451\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B127-preprints-107672\" class=\"html-xxx\" data-content=\"127.\">Zhou, B.; Xu, K.; Zheng, X.; Chen, T.; Wang, J.; Song, Y.; Shao, Y.; Zheng, S. , Application of exosomes as liquid biopsy in clinical diagnosis. \u003Cspan class=\"html-italic\">Signal Transduction and Targeted Therapy\u003C/span> \u003Cb>2020\u003C/b>, 5. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Application+of+exosomes+as+liquid+biopsy+in+clinical+diagnosis&author=Zhou,+B.&author=Xu,+K.&author=Zheng,+X.&author=Chen,+T.&author=Wang,+J.&author=Song,+Y.&author=Shao,+Y.&author=Zheng,+S.&publication_year=2020&journal=Signal+Transduction+and+Targeted+Therapy&pages=5&doi=10.1038/s41392-020-00258-9&pmid=32747657\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41392-020-00258-9\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/32747657\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B128-preprints-107672\" class=\"html-xxx\" data-content=\"128.\">Mustafa Hellou, M.; Górska, A.; Mazzaferri, F.; Cremonini, E.; Gentilotti, E.; De Nardo, P.; Poran, I.; Leeflang, M. M.; Tacconelli, E.; Paul, M. , Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysis. \u003Cspan class=\"html-italic\">Clinical Microbiology and Infection\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">27\u003C/span>, 341–51. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Nucleic+acid+amplification+tests+on+respiratory+samples+for+the+diagnosis+of+coronavirus+infections:+a+systematic+review+and+meta-analysis&author=Mustafa+Hellou,+M.&author=G%C3%B3rska,+A.&author=Mazzaferri,+F.&author=Cremonini,+E.&author=Gentilotti,+E.&author=De+Nardo,+P.&author=Poran,+I.&author=Leeflang,+M.+M.&author=Tacconelli,+E.&author=Paul,+M.&publication_year=2021&journal=Clinical+Microbiology+and+Infection&volume=27&pages=341%E2%80%9351&doi=10.1016/j.cmi.2020.11.002&pmid=33188933\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.cmi.2020.11.002\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33188933\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B129-preprints-107672\" class=\"html-xxx\" data-content=\"129.\">Ding, Z.; Wang, N.; Ji, N.; Chen, Z.-S. , Proteomics technologies for cancer liquid biopsies. \u003Cspan class=\"html-italic\">Molecular Cancer\u003C/span> \u003Cb>2022\u003C/b>, 21. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Proteomics+technologies+for+cancer+liquid+biopsies&author=Ding,+Z.&author=Wang,+N.&author=Ji,+N.&author=Chen,+Z.-S.&publication_year=2022&journal=Molecular+Cancer&pages=21&doi=10.1186/s12943-022-01526-8&pmid=35168611\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1186/s12943-022-01526-8\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35168611\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B130-preprints-107672\" class=\"html-xxx\" data-content=\"130.\">Pu, R.; Liu, S.; Ren, X.; Shi, D.; Ba, Y.; Huo, Y.; Zhang, W.; Ma, L.; Liu, Y.; Yang, Y.; Cheng, N. , The screening value of RT-LAMP and RT-PCR in the diagnosis of COVID-19: systematic review and meta-analysis. \u003Cspan class=\"html-italic\">J Virol Methods\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">300\u003C/span>, 114392. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+screening+value+of+RT-LAMP+and+RT-PCR+in+the+diagnosis+of+COVID-19:+systematic+review+and+meta-analysis&author=Pu,+R.&author=Liu,+S.&author=Ren,+X.&author=Shi,+D.&author=Ba,+Y.&author=Huo,+Y.&author=Zhang,+W.&author=Ma,+L.&author=Liu,+Y.&author=Yang,+Y.&publication_year=2022&journal=J+Virol+Methods&volume=300&pages=114392&doi=10.1016/j.jviromet.2021.114392&pmid=34856308\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.jviromet.2021.114392\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34856308\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B131-preprints-107672\" class=\"html-xxx\" data-content=\"131.\">Bhardwaj, T.; Gadhave, K.; Kapuganti, S. K.; Kumar, P.; Brotzakis, Z. F.; Saumya, K. U.; Nayak, N.; Kumar, A.; Joshi, R.; Mukherjee, B.; Bhardwaj, A.; Thakur, K. G.; Garg, N.; Vendruscolo, M.; Giri, R. , Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. \u003Cspan class=\"html-italic\">Nature Communications\u003C/span> \u003Cb>2023\u003C/b>, 14. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Amyloidogenic+proteins+in+the+SARS-CoV+and+SARS-CoV-2+proteomes&author=Bhardwaj,+T.&author=Gadhave,+K.&author=Kapuganti,+S.+K.&author=Kumar,+P.&author=Brotzakis,+Z.+F.&author=Saumya,+K.+U.&author=Nayak,+N.&author=Kumar,+A.&author=Joshi,+R.&author=Mukherjee,+B.&publication_year=2023&journal=Nature+Communications&pages=14&doi=10.1038/s41467-023-36234-4&pmid=36806058\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41467-023-36234-4\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/36806058\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B132-preprints-107672\" class=\"html-xxx\" data-content=\"132.\">Pan, K. M.; Baldwin, M.; Nguyen, J.; Gasset, M.; Serban, A.; Groth, D.; Mehlhorn, I.; Huang, Z.; Fletterick, R. J.; Cohen, F. E. , Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. \u003Cspan class=\"html-italic\">Proceedings of the National Academy of Sciences\u003C/span> \u003Cb>1993\u003C/b>, \u003Cspan class=\"html-italic\">90\u003C/span>, 10962–66. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Conversion+of+alpha-helices+into+beta-sheets+features+in+the+formation+of+the+scrapie+prion+proteins&author=Pan,+K.+M.&author=Baldwin,+M.&author=Nguyen,+J.&author=Gasset,+M.&author=Serban,+A.&author=Groth,+D.&author=Mehlhorn,+I.&author=Huang,+Z.&author=Fletterick,+R.+J.&author=Cohen,+F.+E.&publication_year=1993&journal=Proceedings+of+the+National+Academy+of+Sciences&volume=90&pages=10962%E2%80%9366&doi=10.1073/pnas.90.23.10962\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1073/pnas.90.23.10962\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B133-preprints-107672\" class=\"html-xxx\" data-content=\"133.\">133. Langeveld, Jan P. M.; Wang, J. J.; Van de Wiel, Dick F. M.; Shih, Giles C.; Garssen, G. J.; Bossers, A.; Shih, Jason C. H., Enzymatic Degradation of Prion Protein in Brain Stem from Infected Cattle and Sheep. \u003Cspan class=\"html-italic\">The Journal of Infectious Diseases 2003, 188, (11), 1782-89\u003C/span>.\u003C/li>\n\u003Cli id=\"B134-preprints-107672\" class=\"html-xxx\" data-content=\"134.\">Prusiner, S. B.; Groth, D. F.; McKinley, M. P.; Cochran, S. P.; Bowman, K. A.; Kasper, K. C. , Thiocyanate and hydroxyl ions inactivate the scrapie agent. \u003Cspan class=\"html-italic\">Proceedings of the National Academy of Sciences\u003C/span> \u003Cb>1981\u003C/b>, \u003Cspan class=\"html-italic\">78\u003C/span>, 4606–10. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Thiocyanate+and+hydroxyl+ions+inactivate+the+scrapie+agent&author=Prusiner,+S.+B.&author=Groth,+D.+F.&author=McKinley,+M.+P.&author=Cochran,+S.+P.&author=Bowman,+K.+A.&author=Kasper,+K.+C.&publication_year=1981&journal=Proceedings+of+the+National+Academy+of+Sciences&volume=78&pages=4606%E2%80%9310&doi=10.1073/pnas.78.7.4606\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1073/pnas.78.7.4606\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B135-preprints-107672\" class=\"html-xxx\" data-content=\"135.\">Race, R. E.; Raymond, G. J. , Inactivation of Transmissible Spongiform Encephalopathy (Prion) Agents by Environ LpH. \u003Cspan class=\"html-italic\">Journal of Virology\u003C/span> \u003Cb>2004\u003C/b>, \u003Cspan class=\"html-italic\">78\u003C/span>, 2164–65. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Inactivation+of+Transmissible+Spongiform+Encephalopathy+(Prion)+Agents+by+Environ+LpH&author=Race,+R.+E.&author=Raymond,+G.+J.&publication_year=2004&journal=Journal+of+Virology&volume=78&pages=2164%E2%80%9365&doi=10.1128/JVI.78.4.2164-2165.2004&pmid=14747583\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1128/JVI.78.4.2164-2165.2004\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/14747583\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B136-preprints-107672\" class=\"html-xxx\" data-content=\"136.\">Peretz, D.; Supattapone, S.; Giles, K.; Vergara, J.; Freyman, Y.; Lessard, P.; Safar, J. G.; Glidden, D. V.; McCulloch, C.; Nguyen, H.-O. B.; Scott, M.; DeArmond, S. J.; Prusiner, S. B. , Inactivation of Prions by Acidic Sodium Dodecyl Sulfate. \u003Cspan class=\"html-italic\">Journal of Virology\u003C/span> \u003Cb>2006\u003C/b>, \u003Cspan class=\"html-italic\">80\u003C/span>, 322–31. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Inactivation+of+Prions+by+Acidic+Sodium+Dodecyl+Sulfate&author=Peretz,+D.&author=Supattapone,+S.&author=Giles,+K.&author=Vergara,+J.&author=Freyman,+Y.&author=Lessard,+P.&author=Safar,+J.+G.&author=Glidden,+D.+V.&author=McCulloch,+C.&author=Nguyen,+H.-O.+B.&publication_year=2006&journal=Journal+of+Virology&volume=80&pages=322%E2%80%9331&doi=10.1128/JVI.80.1.322-331.2006&pmid=16352557\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1128/JVI.80.1.322-331.2006\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/16352557\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B137-preprints-107672\" class=\"html-xxx\" data-content=\"137.\">Tanikawa, T.; Kiba, Y.; Yu, J.; Hsu, K.; Chen, S.; Ishii, A.; Yokogawa, T.; Suzuki, R.; Inoue, Y.; Kitamura, M. , Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. \u003Cspan class=\"html-italic\">Molecules\u003C/span> \u003Cb>2022\u003C/b>, 27. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Degradative+Effect+of+Nattokinase+on+Spike+Protein+of+SARS-CoV-2&author=Tanikawa,+T.&author=Kiba,+Y.&author=Yu,+J.&author=Hsu,+K.&author=Chen,+S.&author=Ishii,+A.&author=Yokogawa,+T.&author=Suzuki,+R.&author=Inoue,+Y.&author=Kitamura,+M.&publication_year=2022&journal=Molecules&pages=27&doi=10.3390/molecules27175405\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/molecules27175405\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B138-preprints-107672\" class=\"html-xxx\" data-content=\"138.\">Tai, M. W.; Sweet, B. V. , Nattokinase for prevention of thrombosis. \u003Cspan class=\"html-italic\">Am J Health Syst Pharm\u003C/span> \u003Cb>2006\u003C/b>, \u003Cspan class=\"html-italic\">63\u003C/span>, 1121–3. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Nattokinase+for+prevention+of+thrombosis&author=Tai,+M.+W.&author=Sweet,+B.+V.&publication_year=2006&journal=Am+J+Health+Syst+Pharm&volume=63&pages=1121%E2%80%933&doi=10.2146/ajhp050509&pmid=16754735\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.2146/ajhp050509\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/16754735\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B139-preprints-107672\" class=\"html-xxx\" data-content=\"139.\">Weng, Y.; Yao, J.; Sparks, S.; Wang, K. Y. , Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. \u003Cspan class=\"html-italic\">Int J Mol Sci\u003C/span> \u003Cb>2017\u003C/b>, 18. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Nattokinase:+An+Oral+Antithrombotic+Agent+for+the+Prevention+of+Cardiovascular+Disease&author=Weng,+Y.&author=Yao,+J.&author=Sparks,+S.&author=Wang,+K.+Y.&publication_year=2017&journal=Int+J+Mol+Sci&pages=18&doi=10.3390/ijms18030523&pmid=28264497\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/ijms18030523\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/28264497\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B140-preprints-107672\" class=\"html-xxx\" data-content=\"140.\">Chen, H.; McGowan, E. M.; Ren, N.; Lal, S.; Nassif, N.; Shad-Kaneez, F.; Qu, X.; Lin, Y. , Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. \u003Cspan class=\"html-italic\">Biomark Insights\u003C/span> \u003Cb>2018\u003C/b>, \u003Cspan class=\"html-italic\">13\u003C/span>, 1177271918785130. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Nattokinase:+A+Promising+Alternative+in+Prevention+and+Treatment+of+Cardiovascular+Diseases&author=Chen,+H.&author=McGowan,+E.+M.&author=Ren,+N.&author=Lal,+S.&author=Nassif,+N.&author=Shad-Kaneez,+F.&author=Qu,+X.&author=Lin,+Y.&publication_year=2018&journal=Biomark+Insights&volume=13&pages=1177271918785130&doi=10.1177/1177271918785130&pmid=30013308\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1177/1177271918785130\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/30013308\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B141-preprints-107672\" class=\"html-xxx\" data-content=\"141.\">Schaffner, A.; Risch, L.; Weber, M.; Thiel, S.; Jungert, K.; Pichler, M.; Wohlwend, N.; Lung, T.; Ritzler, M.; Hillmann, D.; Copeland, S.; Renz, H.; Paprotny, M.; Risch, M. , Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: a population-based study. \u003Cspan class=\"html-italic\">Clin Chem Lab Med\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">59\u003C/span>, e49–e51. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Sustained+SARS-CoV-2+nucleocapsid+antibody+levels+in+nonsevere+COVID-19:+a+population-based+study&author=Schaffner,+A.&author=Risch,+L.&author=Weber,+M.&author=Thiel,+S.&author=Jungert,+K.&author=Pichler,+M.&author=Wohlwend,+N.&author=Lung,+T.&author=Ritzler,+M.&author=Hillmann,+D.&publication_year=2020&journal=Clin+Chem+Lab+Med&volume=59&pages=e49%E2%80%93e51&doi=10.1515/cclm-2020-1347\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1515/cclm-2020-1347\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B142-preprints-107672\" class=\"html-xxx\" data-content=\"142.\">Chansaenroj, J.; Yorsaeng, R.; Posuwan, N.; Puenpa, J.; Wanlapakorn, N.; Sudhinaraset, N.; Sripramote, M.; Chalongviriyalert, P.; Jirajariyavej, S.; Kiatpanabhikul, P.; Saiyarin, J.; Soudon, C.; Thienfaidee, O.; Palakawong Na Ayuthaya, T.; Brukesawan, C.; Chirathaworn, C.; Intharasongkroh, D.; Chaiwanichsiri, D.; Issarasongkhram, M.; Kitphati, R.; Mungaomklang, A.; Nagavajara, P.; Poovorawan, Y. , Long-term specific IgG response to SARS-CoV-2 nucleocapsid protein in recovered COVID-19 patients. \u003Cspan class=\"html-italic\">Sci Rep\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">11\u003C/span>, 23216. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Long-term+specific+IgG+response+to+SARS-CoV-2+nucleocapsid+protein+in+recovered+COVID-19+patients&author=Chansaenroj,+J.&author=Yorsaeng,+R.&author=Posuwan,+N.&author=Puenpa,+J.&author=Wanlapakorn,+N.&author=Sudhinaraset,+N.&author=Sripramote,+M.&author=Chalongviriyalert,+P.&author=Jirajariyavej,+S.&author=Kiatpanabhikul,+P.&publication_year=2021&journal=Sci+Rep&volume=11&pages=23216&doi=10.1038/s41598-021-02659-4\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41598-021-02659-4\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B143-preprints-107672\" class=\"html-xxx\" data-content=\"143.\">Van Elslande, J.; Oyaert, M.; Ailliet, S.; Van Ranst, M.; Lorent, N.; Vande Weygaerde, Y.; Andre, E.; Lagrou, K.; Vandendriessche, S.; Vermeersch, P. , Longitudinal follow-up of IgG anti-nucleocapsid antibodies in SARS-CoV-2 infected patients up to eight months after infection. \u003Cspan class=\"html-italic\">J Clin Virol\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">136\u003C/span>, 104765. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Longitudinal+follow-up+of+IgG+anti-nucleocapsid+antibodies+in+SARS-CoV-2+infected+patients+up+to+eight+months+after+infection&author=Van+Elslande,+J.&author=Oyaert,+M.&author=Ailliet,+S.&author=Van+Ranst,+M.&author=Lorent,+N.&author=Vande+Weygaerde,+Y.&author=Andre,+E.&author=Lagrou,+K.&author=Vandendriessche,+S.&author=Vermeersch,+P.&publication_year=2021&journal=J+Clin+Virol&volume=136&pages=104765&doi=10.1016/j.jcv.2021.104765\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.jcv.2021.104765\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B144-preprints-107672\" class=\"html-xxx\" data-content=\"144.\">Faksova, K.; Walsh, D.; Jiang, Y.; Griffin, J.; Phillips, A.; Gentile, A.; Kwong, J. C.; Macartney, K.; Naus, M.; Grange, Z.; Escolano, S.; Sepulveda, G.; Shetty, A.; Pillsbury, A.; Sullivan, C.; Naveed, Z.; Janjua, N. Z.; Giglio, N.; Perala, J.; Nasreen, S.; Gidding, H.; Hovi, P.; Vo, T.; Cui, F.; Deng, L.; Cullen, L.; Artama, M.; Weintraub, E.; Lu, H.; Clothier, H. J.; Batty, K.; Paynter, J.; Petousis-Harris, H.; Buttery, J.; Black, S.; Hviid, A. , COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals. \u003Cspan class=\"html-italic\">Vaccine\u003C/span> \u003Cb>2024\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+COVID-19+vaccines+and+adverse+events+of+special+interest:+A+multinational+Global+Vaccine+Data+Network+(GVDN)+cohort+study+of+99+million+vaccinated+individuals&author=Faksova,+K.&author=Walsh,+D.&author=Jiang,+Y.&author=Griffin,+J.&author=Phillips,+A.&author=Gentile,+A.&author=Kwong,+J.+C.&author=Macartney,+K.&author=Naus,+M.&author=Grange,+Z.&publication_year=2024&journal=Vaccine&doi=10.1016/j.vaccine.2024.01.100\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.vaccine.2024.01.100\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B145-preprints-107672\" class=\"html-xxx\" data-content=\"145.\">Stroup, D. F.; Berlin, J. A.; Morton, S. C.; Olkin, I.; Williamson, G. D.; Rennie, D.; Moher, D.; Becker, B. J.; Sipe, T. A.; Thacker, S. B. , Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. \u003Cspan class=\"html-italic\">JAMA 2000, 283, (15), 2008-12\u003C/span>.\u003C/li>\n\u003Cli id=\"B146-preprints-107672\" class=\"html-xxx\" data-content=\"146.\">Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G.; Group, P. , Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. \u003Cspan class=\"html-italic\">Int J Surg\u003C/span> \u003Cb>2010\u003C/b>, \u003Cspan class=\"html-italic\">8\u003C/span>, 336–41. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Preferred+reporting+items+for+systematic+reviews+and+meta-analyses:+the+PRISMA+statement&author=Moher,+D.&author=Liberati,+A.&author=Tetzlaff,+J.&author=Altman,+D.+G.&author=Group,+P.&publication_year=2010&journal=Int+J+Surg&volume=8&pages=336%E2%80%9341&doi=10.1016/j.ijsu.2010.02.007\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.ijsu.2010.02.007\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B147-preprints-107672\" class=\"html-xxx\" data-content=\"147.\">Murad, M. H.; Montori, V. M.; Ioannidis, J. P.; Jaeschke, R.; Devereaux, P. J.; Prasad, K.; Neumann, I.; Carrasco-Labra, A.; Agoritsas, T.; Hatala, R.; Meade, M. O.; Wyer, P.; Cook, D. J.; Guyatt, G. , How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature. \u003Cspan class=\"html-italic\">JAMA\u003C/span> \u003Cb>2014\u003C/b>, \u003Cspan class=\"html-italic\">312\u003C/span>, 171–9. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+How+to+read+a+systematic+review+and+meta-analysis+and+apply+the+results+to+patient+care:+users'+guides+to+the+medical+literature&author=Murad,+M.+H.&author=Montori,+V.+M.&author=Ioannidis,+J.+P.&author=Jaeschke,+R.&author=Devereaux,+P.+J.&author=Prasad,+K.&author=Neumann,+I.&author=Carrasco-Labra,+A.&author=Agoritsas,+T.&author=Hatala,+R.&publication_year=2014&journal=JAMA&volume=312&pages=171%E2%80%939&doi=10.1001/jama.2014.5559\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1001/jama.2014.5559\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B148-preprints-107672\" class=\"html-xxx\" data-content=\"148.\">Gould, C. V.; Free, R. J.; Bhatnagar, J.; Soto, R. A.; Royer, T. L.; Maley, W. R.; Moss, S.; Berk, M. A.; Craig-Shapiro, R.; Kodiyanplakkal, R. P. L.; Westblade, L. F.; Muthukumar, T.; Puius, Y. A.; Raina, A.; Hadi, A.; Gyure, K. A.; Trief, D.; Pereira, M.; Kuehnert, M. J.; Ballen, V.; Kessler, D. A.; Dailey, K.; Omura, C.; Doan, T.; Miller, S.; Wilson, M. R.; Lehman, J. A.; Ritter, J. M.; Lee, E.; Silva-Flannery, L.; Reagan-Steiner, S.; Velez, J. O.; Laven, J. J.; Fitzpatrick, K. A.; Panella, A.; Davis, E. H.; Hughes, H. R.; Brault, A. C.; St George, K.; Dean, A. B.; Ackelsberg, J.; Basavaraju, S. V.; Chiu, C. Y.; Staples, J. E.; Yellow Fever Vaccine Virus, T.; Transfusion Investigation, T. , Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation. \u003Cspan class=\"html-italic\">Lancet Microbe\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">4\u003C/span>, e711–e21. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Transmission+of+yellow+fever+vaccine+virus+through+blood+transfusion+and+organ+transplantation+in+the+USA+in+2021:+report+of+an+investigation&author=Gould,+C.+V.&author=Free,+R.+J.&author=Bhatnagar,+J.&author=Soto,+R.+A.&author=Royer,+T.+L.&author=Maley,+W.+R.&author=Moss,+S.&author=Berk,+M.+A.&author=Craig-Shapiro,+R.&author=Kodiyanplakkal,+R.+P.+L.&publication_year=2023&journal=Lancet+Microbe&volume=4&pages=e711%E2%80%93e21&doi=10.1016/S2666-5247(23)00170-2\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/S2666-5247(23)00170-2\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B149-preprints-107672\" class=\"html-xxx\" data-content=\"149.\">Yaqoob, I.; Salah, K.; Jayaraman, R.; Al-Hammadi, Y. , Blockchain for healthcare data management: opportunities, challenges, and future recommendations. \u003Cspan class=\"html-italic\">Neural Computing and Applications\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">34\u003C/span>, 11475–90. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Blockchain+for+healthcare+data+management:+opportunities,+challenges,+and+future+recommendations&author=Yaqoob,+I.&author=Salah,+K.&author=Jayaraman,+R.&author=Al-Hammadi,+Y.&publication_year=2021&journal=Neural+Computing+and+Applications&volume=34&pages=11475%E2%80%9390&doi=10.1007/s00521-020-05519-w\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1007/s00521-020-05519-w\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B150-preprints-107672\" class=\"html-xxx\" data-content=\"150.\">Musamih, A.; Salah, K.; Jayaraman, R.; Arshad, J.; Debe, M.; Al-Hammadi, Y.; Ellahham, S. , A Blockchain-Based Approach for Drug Traceability in Healthcare Supply Chain. \u003Cspan class=\"html-italic\">IEEE Access\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">9\u003C/span>, 9728–43. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+A+Blockchain-Based+Approach+for+Drug+Traceability+in+Healthcare+Supply+Chain&author=Musamih,+A.&author=Salah,+K.&author=Jayaraman,+R.&author=Arshad,+J.&author=Debe,+M.&author=Al-Hammadi,+Y.&author=Ellahham,+S.&publication_year=2021&journal=IEEE+Access&volume=9&pages=9728%E2%80%9343&doi=10.1109/ACCESS.2021.3049920\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1109/ACCESS.2021.3049920\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B151-preprints-107672\" class=\"html-xxx\" data-content=\"151.\">WHO, International Health Regulations (2005). 2nd edn. In World Health Organization: Geneva, 2008.\u003C/li>\n\u003Cli id=\"B152-preprints-107672\" class=\"html-xxx\" data-content=\"152.\">Bakanidze, L.; Imnadze, P.; Perkins, D. , Biosafety and biosecurity as essential pillars of international health security and cross-cutting elements of biological nonproliferation. \u003Cspan class=\"html-italic\">BMC Public Health 2010, 10, (Suppl 1)\u003C/span>.\u003C/li>\n\u003Cli id=\"B153-preprints-107672\" class=\"html-xxx\" data-content=\"153.\">WHO, Global Covid-19 Vaccination Strategy in a Changing World July 2022 update. In World Health Organization: Geneva, 2022.\u003C/li>\n\u003Cli id=\"B154-preprints-107672\" class=\"html-xxx\" data-content=\"154.\">Wu, Y. C.; Chen, C. S.; Chan, Y. J. , The outbreak of COVID-19: An overview. \u003Cspan class=\"html-italic\">J Chin Med Assoc\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">83\u003C/span>, 217–20. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+outbreak+of+COVID-19:+An+overview&author=Wu,+Y.+C.&author=Chen,+C.+S.&author=Chan,+Y.+J.&publication_year=2020&journal=J+Chin+Med+Assoc&volume=83&pages=217%E2%80%9320&doi=10.1097/JCMA.0000000000000270\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1097/JCMA.0000000000000270\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B155-preprints-107672\" class=\"html-xxx\" data-content=\"155.\">Beeckman, D. S. A.; Rudelsheim, P. , Biosafety and Biosecurity in Containment: A Regulatory Overview. \u003Cspan class=\"html-italic\">Front Bioeng Biotechnol\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">8\u003C/span>, 650. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Biosafety+and+Biosecurity+in+Containment:+A+Regulatory+Overview&author=Beeckman,+D.+S.+A.&author=Rudelsheim,+P.&publication_year=2020&journal=Front+Bioeng+Biotechnol&volume=8&pages=650&doi=10.3389/fbioe.2020.00650\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3389/fbioe.2020.00650\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B156-preprints-107672\" class=\"html-xxx\" data-content=\"156.\">Berg, P.; Baltimore, D.; Brenner, S.; Roblin, R. O.; Singer, M. F. , Summary statement of the Asilomar conference on recombinant DNA molecules. \u003Cspan class=\"html-italic\">Proc Natl Acad Sci U S A\u003C/span> \u003Cb>1975\u003C/b>, \u003Cspan class=\"html-italic\">72\u003C/span>, 1981–4. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Summary+statement+of+the+Asilomar+conference+on+recombinant+DNA+molecules&author=Berg,+P.&author=Baltimore,+D.&author=Brenner,+S.&author=Roblin,+R.+O.&author=Singer,+M.+F.&publication_year=1975&journal=Proc+Natl+Acad+Sci+U+S+A&volume=72&pages=1981%E2%80%934&doi=10.1073/pnas.72.6.1981\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1073/pnas.72.6.1981\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B157-preprints-107672\" class=\"html-xxx\" data-content=\"157.\">Barinaga, M. , Asilomar revisited: lessons for today? \u003Cspan class=\"html-italic\">Science\u003C/span> \u003Cb>2000\u003C/b>, \u003Cspan class=\"html-italic\">287\u003C/span>, 1584–5. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Asilomar+revisited:+lessons+for+today?&author=Barinaga,+M.&publication_year=2000&journal=Science&volume=287&pages=1584%E2%80%935&doi=10.1126/science.287.5458.1584&pmid=10766605\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1126/science.287.5458.1584\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/10766605\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B158-preprints-107672\" class=\"html-xxx\" data-content=\"158.\">Krimsky, S. , From Asilomar to industrial biotechnology: risks, reductionism and regulation. \u003Cspan class=\"html-italic\">Sci Cult (Lond)\u003C/span> \u003Cb>2005\u003C/b>, \u003Cspan class=\"html-italic\">14\u003C/span>, 309–23. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+From+Asilomar+to+industrial+biotechnology:+risks,+reductionism+and+regulation&author=Krimsky,+S.&publication_year=2005&journal=Sci+Cult+(Lond)&volume=14&pages=309%E2%80%9323&doi=10.1080/09505430500368998&pmid=16619467\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1080/09505430500368998\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/16619467\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B159-preprints-107672\" class=\"html-xxx\" data-content=\"159.\">Gregorowius, D.; Biller-Andorno, N.; Deplazes-Zemp, A. , The role of scientific self-regulation for the control of genome editing in the human germline: The lessons from the Asilomar and the Napa meetings show how self-regulation and public deliberation can lead to regulation of new biotechnologies. \u003Cspan class=\"html-italic\">EMBO Rep\u003C/span> \u003Cb>2017\u003C/b>, \u003Cspan class=\"html-italic\">18\u003C/span>, 355–58. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+The+role+of+scientific+self-regulation+for+the+control+of+genome+editing+in+the+human+germline:+The+lessons+from+the+Asilomar+and+the+Napa+meetings+show+how+self-regulation+and+public+deliberation+can+lead+to+regulation+of+new+biotechnologies&author=Gregorowius,+D.&author=Biller-Andorno,+N.&author=Deplazes-Zemp,+A.&publication_year=2017&journal=EMBO+Rep&volume=18&pages=355%E2%80%9358&doi=10.15252/embr.201643054\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.15252/embr.201643054\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B160-preprints-107672\" class=\"html-xxx\" data-content=\"160.\">Taylor, D. M. , Inactivation of TSE agents: safety of blood and blood-derived products. \u003Cspan class=\"html-italic\">Transfus Clin Biol\u003C/span> \u003Cb>2003\u003C/b>, \u003Cspan class=\"html-italic\">10\u003C/span>, 23–5. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Inactivation+of+TSE+agents:+safety+of+blood+and+blood-derived+products&author=Taylor,+D.+M.&publication_year=2003&journal=Transfus+Clin+Biol&volume=10&pages=23%E2%80%935&doi=10.1016/S1246-7820(02)00280-X\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/S1246-7820(02)00280-X\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B161-preprints-107672\" class=\"html-xxx\" data-content=\"161.\">Klein, M. A.; Frigg, R.; Flechsig, E.; Raeber, A. J.; Kalinke, U.; Bluethmann, H.; Bootz, F.; Suter, M.; Zinkernagel, R. M.; Aguzzi, A. , A crucial role for B cells in neuroinvasive scrapie. \u003Cspan class=\"html-italic\">Nature\u003C/span> \u003Cb>1997\u003C/b>, \u003Cspan class=\"html-italic\">390\u003C/span>, 687–90. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+A+crucial+role+for+B+cells+in+neuroinvasive+scrapie&author=Klein,+M.+A.&author=Frigg,+R.&author=Flechsig,+E.&author=Raeber,+A.+J.&author=Kalinke,+U.&author=Bluethmann,+H.&author=Bootz,+F.&author=Suter,+M.&author=Zinkernagel,+R.+M.&author=Aguzzi,+A.&publication_year=1997&journal=Nature&volume=390&pages=687%E2%80%9390&doi=10.1038/37789\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/37789\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B162-preprints-107672\" class=\"html-xxx\" data-content=\"162.\">Singh, S.; Kumar, A. , Leukocyte depletion for safe blood transfusion. \u003Cspan class=\"html-italic\">Biotechnol J\u003C/span> \u003Cb>2009\u003C/b>, \u003Cspan class=\"html-italic\">4\u003C/span>, 1140–51. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Leukocyte+depletion+for+safe+blood+transfusion&author=Singh,+S.&author=Kumar,+A.&publication_year=2009&journal=Biotechnol+J&volume=4&pages=1140%E2%80%9351&doi=10.1002/biot.200800182\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1002/biot.200800182\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B163-preprints-107672\" class=\"html-xxx\" data-content=\"163.\">Schmidt, A.; Refaai, M.; Kirkley, S.; Blumberg, N. , Proven and potential clinical benefits of washing red blood cells before transfusion: current perspectives. \u003Cspan class=\"html-italic\">International Journal of Clinical Transfusion Medicine\u003C/span> \u003Cb>2016\u003C/b>, \u003Cspan class=\"html-italic\">Volume 4\u003C/span>, 79–88. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Proven+and+potential+clinical+benefits+of+washing+red+blood+cells+before+transfusion:+current+perspectives&author=Schmidt,+A.&author=Refaai,+M.&author=Kirkley,+S.&author=Blumberg,+N.&publication_year=2016&journal=International+Journal+of+Clinical+Transfusion+Medicine&volume=Volume+4&pages=79%E2%80%9388&doi=10.2147/IJCTM.S101401\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.2147/IJCTM.S101401\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B164-preprints-107672\" class=\"html-xxx\" data-content=\"164.\">Cardigan, R.; New, H. V.; Tinegate, H.; Thomas, S. , Washed red cells: theory and practice. \u003Cspan class=\"html-italic\">Vox Sanguinis\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">115\u003C/span>, 606–16. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Washed+red+cells:+theory+and+practice&author=Cardigan,+R.&author=New,+H.+V.&author=Tinegate,+H.&author=Thomas,+S.&publication_year=2020&journal=Vox+Sanguinis&volume=115&pages=606%E2%80%9316&doi=10.1111/vox.12971\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/vox.12971\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B165-preprints-107672\" class=\"html-xxx\" data-content=\"165.\">Palmqvist, M.; Von Schreeb, J.; Älgå, A. , Autotransfusion in low-resource settings: a scoping review. \u003Cspan class=\"html-italic\">BMJ Open\u003C/span> \u003Cb>2022\u003C/b>, 12. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Autotransfusion+in+low-resource+settings:+a+scoping+review&author=Palmqvist,+M.&author=Von+Schreeb,+J.&author=%C3%84lg%C3%A5,+A.&publication_year=2022&journal=BMJ+Open&pages=12&doi=10.1136/bmjopen-2021-056018\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1136/bmjopen-2021-056018\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B166-preprints-107672\" class=\"html-xxx\" data-content=\"166.\">Mulroney, T. E.; Pöyry, T.; Yam-Puc, J. C.; Rust, M.; Harvey, R. F.; Kalmar, L.; Horner, E.; Booth, L.; Ferreira, A. P.; Stoneley, M.; Sawarkar, R.; Mentzer, A. J.; Lilley, K. S.; Smales, C. M.; von der Haar, T.; Turtle, L.; Dunachie, S.; Klenerman, P.; Thaventhiran, J. E. D.; Willis, A. E. , N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. \u003Cspan class=\"html-italic\">Nature\u003C/span> \u003Cb>2023\u003C/b>. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+N1-methylpseudouridylation+of+mRNA+causes++1+ribosomal+frameshifting&author=Mulroney,+T.+E.&author=P%C3%B6yry,+T.&author=Yam-Puc,+J.+C.&author=Rust,+M.&author=Harvey,+R.+F.&author=Kalmar,+L.&author=Horner,+E.&author=Booth,+L.&author=Ferreira,+A.+P.&author=Stoneley,+M.&publication_year=2023&journal=Nature&doi=10.1038/s41586-023-06800-3\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1038/s41586-023-06800-3\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B167-preprints-107672\" class=\"html-xxx\" data-content=\"167.\">Alameh, M. G.; Tombacz, I.; Bettini, E.; Lederer, K.; Sittplangkoon, C.; Wilmore, J. R.; Gaudette, B. T.; Soliman, O. Y.; Pine, M.; Hicks, P.; Manzoni, T. B.; Knox, J. J.; Johnson, J. L.; Laczko, D.; Muramatsu, H.; Davis, B.; Meng, W.; Rosenfeld, A. M.; Strohmeier, S.; Lin, P. J. C.; Mui, B. L.; Tam, Y. K.; Kariko, K.; Jacquet, A.; Krammer, F.; Bates, P.; Cancro, M. P.; Weissman, D.; Luning Prak, E. T.; Allman, D.; Locci, M.; Pardi, N. , Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. \u003Cspan class=\"html-italic\">Immunity 2021, 54, (12), 2877-92 e7\u003C/span>.\u003C/li>\n\u003Cli id=\"B168-preprints-107672\" class=\"html-xxx\" data-content=\"168.\">Guimaraes, L. E.; Baker, B.; Perricone, C.; Shoenfeld, Y. , Vaccines, adjuvants and autoimmunity. \u003Cspan class=\"html-italic\">Pharmacol Res\u003C/span> \u003Cb>2015\u003C/b>, \u003Cspan class=\"html-italic\">100\u003C/span>, 190–209. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Vaccines,+adjuvants+and+autoimmunity&author=Guimaraes,+L.+E.&author=Baker,+B.&author=Perricone,+C.&author=Shoenfeld,+Y.&publication_year=2015&journal=Pharmacol+Res&volume=100&pages=190%E2%80%93209&doi=10.1016/j.phrs.2015.08.003&pmid=26275795\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.phrs.2015.08.003\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/26275795\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B169-preprints-107672\" class=\"html-xxx\" data-content=\"169.\">Jara, L. J.; Vera-Lastra, O.; Mahroum, N.; Pineda, C.; Shoenfeld, Y. , Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune/inflammatory syndrome expand? \u003Cspan class=\"html-italic\">Clinical Rheumatology\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">41\u003C/span>, 1603–09. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Autoimmune+post-COVID+vaccine+syndromes:+does+the+spectrum+of+autoimmune/inflammatory+syndrome+expand?&author=Jara,+L.+J.&author=Vera-Lastra,+O.&author=Mahroum,+N.&author=Pineda,+C.&author=Shoenfeld,+Y.&publication_year=2022&journal=Clinical+Rheumatology&volume=41&pages=1603%E2%80%9309&doi=10.1007/s10067-022-06149-4&pmid=35378658\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1007/s10067-022-06149-4\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/35378658\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B170-preprints-107672\" class=\"html-xxx\" data-content=\"170.\">Kaulen, L. D.; Doubrovinskaia, S.; Mooshage, C.; Jordan, B.; Purrucker, J.; Haubner, C.; Seliger, C.; Lorenz, H. M.; Nagel, S.; Wildemann, B.; Bendszus, M.; Wick, W.; Schönenberger, S. , Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. \u003Cspan class=\"html-italic\">European Journal of Neurology\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">29\u003C/span>, 555–63. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Neurological+autoimmune+diseases+following+vaccinations+against+SARS-CoV-2:+a+case+series&author=Kaulen,+L.+D.&author=Doubrovinskaia,+S.&author=Mooshage,+C.&author=Jordan,+B.&author=Purrucker,+J.&author=Haubner,+C.&author=Seliger,+C.&author=Lorenz,+H.+M.&author=Nagel,+S.&author=Wildemann,+B.&publication_year=2021&journal=European+Journal+of+Neurology&volume=29&pages=555%E2%80%9363&doi=10.1111/ene.15147&pmid=34668274\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1111/ene.15147\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34668274\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B171-preprints-107672\" class=\"html-xxx\" data-content=\"171.\">Agmon-Levin, N.; Damoiseaux, J.; Kallenberg, C.; Sack, U.; Witte, T.; Herold, M.; Bossuyt, X.; Musset, L.; Cervera, R.; Plaza-Lopez, A.; Dias, C.; Sousa, M. J.; Radice, A.; Eriksson, C.; Hultgren, O.; Viander, M.; Khamashta, M.; Regenass, S.; Andrade, L. E. C.; Wiik, A.; Tincani, A.; Rönnelid, J.; Bloch, D. B.; Fritzler, M. J.; Chan, E. K. L.; Garcia-De La Torre, I.; Konstantinov, K. N.; Lahita, R.; Wilson, M.; Vainio, O.; Fabien, N.; Sinico, R. A.; Meroni, P.; Shoenfeld, Y. , International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. \u003Cspan class=\"html-italic\">Annals of the Rheumatic Diseases\u003C/span> \u003Cb>2014\u003C/b>, \u003Cspan class=\"html-italic\">73\u003C/span>, 17–23. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+International+recommendations+for+the+assessment+of+autoantibodies+to+cellular+antigens+referred+to+as+anti-nuclear+antibodies&author=Agmon-Levin,+N.&author=Damoiseaux,+J.&author=Kallenberg,+C.&author=Sack,+U.&author=Witte,+T.&author=Herold,+M.&author=Bossuyt,+X.&author=Musset,+L.&author=Cervera,+R.&author=Plaza-Lopez,+A.&publication_year=2014&journal=Annals+of+the+Rheumatic+Diseases&volume=73&pages=17%E2%80%9323&doi=10.1136/annrheumdis-2013-203863&pmid=24126457\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1136/annrheumdis-2013-203863\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/24126457\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B172-preprints-107672\" class=\"html-xxx\" data-content=\"172.\">Xiao, Z. X.; Miller, J. S.; Zheng, S. G. , An updated advance of autoantibodies in autoimmune diseases. \u003Cspan class=\"html-italic\">Autoimmun Rev\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">20\u003C/span>, 102743. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+An+updated+advance+of+autoantibodies+in+autoimmune+diseases&author=Xiao,+Z.+X.&author=Miller,+J.+S.&author=Zheng,+S.+G.&publication_year=2021&journal=Autoimmun+Rev&volume=20&pages=102743&doi=10.1016/j.autrev.2020.102743&pmid=33333232\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.autrev.2020.102743\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/33333232\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B173-preprints-107672\" class=\"html-xxx\" data-content=\"173.\">Varghese, J. L.; Fung, A. W. S.; Mattman, A.; Quach, T. T. T.; Gauiran, D. T. V.; Carruthers, M. N.; Chen, L. Y. C. , Clinical utility of serum IgG4 measurement. \u003Cspan class=\"html-italic\">Clin Chim Acta\u003C/span> \u003Cb>2020\u003C/b>, \u003Cspan class=\"html-italic\">506\u003C/span>, 228–35. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Clinical+utility+of+serum+IgG4+measurement&author=Varghese,+J.+L.&author=Fung,+A.+W.+S.&author=Mattman,+A.&author=Quach,+T.+T.+T.&author=Gauiran,+D.+T.+V.&author=Carruthers,+M.+N.&author=Chen,+L.+Y.+C.&publication_year=2020&journal=Clin+Chim+Acta&volume=506&pages=228%E2%80%9335&doi=10.1016/j.cca.2020.04.001&pmid=32272158\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1016/j.cca.2020.04.001\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/32272158\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B174-preprints-107672\" class=\"html-xxx\" data-content=\"174.\">Katz, G.; Stone, J. H. , Clinical Perspectives on IgG4-Related Disease and Its Classification. \u003Cspan class=\"html-italic\">Annu Rev Med\u003C/span> \u003Cb>2022\u003C/b>, \u003Cspan class=\"html-italic\">73\u003C/span>, 545–62. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Clinical+Perspectives+on+IgG4-Related+Disease+and+Its+Classification&author=Katz,+G.&author=Stone,+J.+H.&publication_year=2022&journal=Annu+Rev+Med&volume=73&pages=545%E2%80%9362&doi=10.1146/annurev-med-050219-034449&pmid=34669430\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1146/annurev-med-050219-034449\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/34669430\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B175-preprints-107672\" class=\"html-xxx\" data-content=\"175.\">Tsang, S.; Royse, C. F.; Terkawi, A. S. , Guidelines for developing, translating, and validating a questionnaire in perioperative and pain medicine. \u003Cspan class=\"html-italic\">Saudi J Anaesth\u003C/span> \u003Cb>2017\u003C/b>, \u003Cspan class=\"html-italic\">(Suppl 1)\u003C/span> (Suppl 1), S80–S89. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Guidelines+for+developing,+translating,+and+validating+a+questionnaire+in+perioperative+and+pain+medicine&author=Tsang,+S.&author=Royse,+C.+F.&author=Terkawi,+A.+S.&publication_year=2017&journal=Saudi+J+Anaesth&volume=(Suppl+1)&pages=S80%E2%80%93S89&doi=10.4103/sja.SJA_203_17\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.4103/sja.SJA_203_17\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B176-preprints-107672\" class=\"html-xxx\" data-content=\"176.\">Semmler, A.; Mundorf, A. K.; Kuechler, A. S.; Schulze-Bosse, K.; Heidecke, H.; Schulze-Forster, K.; Schott, M.; Uhrberg, M.; Weinhold, S.; Lackner, K. J.; Pawlitzki, M.; Meuth, S. G.; Boege, F.; Ruhrländer, J. , Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers. \u003Cspan class=\"html-italic\">Vaccines\u003C/span> \u003Cb>2023\u003C/b>, 11. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Chronic+Fatigue+and+Dysautonomia+following+COVID-19+Vaccination+Is+Distinguished+from+Normal+Vaccination+Response+by+Altered+Blood+Markers&author=Semmler,+A.&author=Mundorf,+A.+K.&author=Kuechler,+A.+S.&author=Schulze-Bosse,+K.&author=Heidecke,+H.&author=Schulze-Forster,+K.&author=Schott,+M.&author=Uhrberg,+M.&author=Weinhold,+S.&author=Lackner,+K.+J.&publication_year=2023&journal=Vaccines&pages=11&doi=10.3390/vaccines11111642&pmid=38005974\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/vaccines11111642\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>] [\u003Ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/38005974\" class=\"cross-ref pub_med\" data-typ=\"pmid\" target=\"_blank\" rel=\"noopener noreferrer\">PubMed\u003C/a>]\u003C/li>\n\u003Cli id=\"B177-preprints-107672\" class=\"html-xxx\" data-content=\"177.\">Islam, A.; Bashir, M. S.; Joyce, K.; Rashid, H.; Laher, I.; Elshazly, S. , An Update on COVID-19 Vaccine Induced Thrombotic Thrombocytopenia Syndrome and Some Management Recommendations. \u003Cspan class=\"html-italic\">Molecules\u003C/span> \u003Cb>2021\u003C/b>, 26. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+An+Update+on+COVID-19+Vaccine+Induced+Thrombotic+Thrombocytopenia+Syndrome+and+Some+Management+Recommendations&author=Islam,+A.&author=Bashir,+M.+S.&author=Joyce,+K.&author=Rashid,+H.&author=Laher,+I.&author=Elshazly,+S.&publication_year=2021&journal=Molecules&pages=26&doi=10.3390/molecules26165004\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.3390/molecules26165004\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B178-preprints-107672\" class=\"html-xxx\" data-content=\"178.\">Mevorach, D.; Anis, E.; Cedar, N.; Bromberg, M.; Haas, E. J.; Nadir, E.; Olsha-Castell, S.; Arad, D.; Hasin, T.; Levi, N.; Asleh, R.; Amir, O.; Meir, K.; Cohen, D.; Dichtiar, R.; Novick, D.; Hershkovitz, Y.; Dagan, R.; Leitersdorf, I.; Ben-Ami, R.; Miskin, I.; Saliba, W.; Muhsen, K.; Levi, Y.; Green, M. S.; Keinan-Boker, L.; Alroy-Preis, S. , Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel. \u003Cspan class=\"html-italic\">New England Journal of Medicine\u003C/span> \u003Cb>2021\u003C/b>, \u003Cspan class=\"html-italic\">385\u003C/span>, 2140–49. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Myocarditis+after+BNT162b2+mRNA+Vaccine+against+Covid-19+in+Israel&author=Mevorach,+D.&author=Anis,+E.&author=Cedar,+N.&author=Bromberg,+M.&author=Haas,+E.+J.&author=Nadir,+E.&author=Olsha-Castell,+S.&author=Arad,+D.&author=Hasin,+T.&author=Levi,+N.&publication_year=2021&journal=New+England+Journal+of+Medicine&volume=385&pages=2140%E2%80%9349&doi=10.1056/NEJMoa2109730\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1056/NEJMoa2109730\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003Cli id=\"B179-preprints-107672\" class=\"html-xxx\" data-content=\"179.\">Nakahara, T.; Iwabuchi, Y.; Miyazawa, R.; Tonda, K.; Shiga, T.; Strauss, H. W.; Antoniades, C.; Narula, J.; Jinzaki, M. , Assessment of Myocardial (18)F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2-vaccinated and Nonvaccinated Patients. \u003Cspan class=\"html-italic\">Radiology\u003C/span> \u003Cb>2023\u003C/b>, \u003Cspan class=\"html-italic\">308\u003C/span>, e230743. [\u003Ca href=\"https://scholar.google.com/scholar_lookup?title=,+Assessment+of+Myocardial+(18)F-FDG+Uptake+at+PET/CT+in+Asymptomatic+SARS-CoV-2-vaccinated+and+Nonvaccinated+Patients&author=Nakahara,+T.&author=Iwabuchi,+Y.&author=Miyazawa,+R.&author=Tonda,+K.&author=Shiga,+T.&author=Strauss,+H.+W.&author=Antoniades,+C.&author=Narula,+J.&author=Jinzaki,+M.&publication_year=2023&journal=Radiology&volume=308&pages=e230743&doi=10.1148/radiol.230743\" class=\"google-scholar\" target=\"_blank\" rel=\"noopener noreferrer\">Google Scholar\u003C/a>] [\u003Ca href=\"https://doi.org/10.1148/radiol.230743\" class=\"cross-ref\" target=\"_blank\" rel=\"noopener noreferrer\">CrossRef\u003C/a>]\u003C/li>\n\u003C/ol>\u003C/section>\u003Csection id=\"FiguresandTables\" type=\"display-objects\">\u003Cdiv class=\"html-fig-wrap\" id=\"preprints-107672-f001\">\n \u003Cdiv class=\"html-fig_img\">\n \u003Cdiv class=\"html-figpopup html-figpopup-link\" href=\"#fig_body_display_preprints-107672-f001\">\n \u003Cimg data-large=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png\" data-original=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png\" alt=\"Preprints 107672 g001\" src=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png\">\n \u003Ca class=\"html-expand html-figpopup\" href=\"#fig_body_display_preprints-107672-f001\">\u003C/a>\n \u003C/div>\n\n \u003C/div>\n \u003Cdiv class=\"html-fig_description\">\n \u003Cb>Figure 1.\u003C/b>\n \u003Cb>Possible mechanisms for spread of spike proteins and modified RNAs throughout the body.\u003C/b> Lipid nanoparticles (LNPs) are transported via the bloodstream to various tissues and organs. Cells that take up the LNPs are thought to produce spike proteins, and some of the spike proteins and modified RNA are released into the blood as exosomes. Exosomes containing spike proteins are transported to various tissues and organs via the bloodstream. LNPs are known to cause inflammation, and spike proteins are known to aggregate red blood cells and platelets, which may pose a risk of microthrombus formation. Note that LNPs and exosomes are drawn large in this figure for clarity.\n\u003C!-- \u003Cp>\u003Ca class=\"html-figpopup\" href=\"#fig_body_display_preprints-107672-f001\">\n Click here to enlarge figure\n \u003C/a>\u003C/p> -->\n\n \u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-fig_show mfp-hide\" id=\"fig_body_display_preprints-107672-f001\">\n \u003Cdiv class=\"html-caption\"> \u003Cb>Figure 1.\u003C/b>\n \u003Cb>Possible mechanisms for spread of spike proteins and modified RNAs throughout the body.\u003C/b> Lipid nanoparticles (LNPs) are transported via the bloodstream to various tissues and organs. Cells that take up the LNPs are thought to produce spike proteins, and some of the spike proteins and modified RNA are released into the blood as exosomes. Exosomes containing spike proteins are transported to various tissues and organs via the bloodstream. LNPs are known to cause inflammation, and spike proteins are known to aggregate red blood cells and platelets, which may pose a risk of microthrombus formation. Note that LNPs and exosomes are drawn large in this figure for clarity.\u003C/div>\n \u003Cdiv class=\"html-img\">\u003Cimg data-large=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png\" data-original=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png\" alt=\"Preprints 107672 g001\" src=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g001.png\">\u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-fig-wrap\" id=\"preprints-107672-f002\">\n \u003Cdiv class=\"html-fig_img\">\n \u003Cdiv class=\"html-figpopup html-figpopup-link\" href=\"#fig_body_display_preprints-107672-f002\">\n \u003Cimg data-large=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png\" data-original=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png\" alt=\"Preprints 107672 g002\" src=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png\">\n \u003Ca class=\"html-expand html-figpopup\" href=\"#fig_body_display_preprints-107672-f002\">\u003C/a>\n \u003C/div>\n\n \u003C/div>\n \u003Cdiv class=\"html-fig_description\">\n \u003Cb>Figure 2.\u003C/b>\n \u003Cb>Proposed PVS risk management cycle.\u003C/b> Summary of items and procedures required for management of blood products derived from genetic vaccine recipients or those affected with spike protein and modified genes. As with any risk management exercise, it is important to constantly revise policies and procedures as risks and problems are identified. PVS, post-vaccination syndrome.\n\u003C!-- \u003Cp>\u003Ca class=\"html-figpopup\" href=\"#fig_body_display_preprints-107672-f002\">\n Click here to enlarge figure\n \u003C/a>\u003C/p> -->\n\n \u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-fig_show mfp-hide\" id=\"fig_body_display_preprints-107672-f002\">\n \u003Cdiv class=\"html-caption\"> \u003Cb>Figure 2.\u003C/b>\n \u003Cb>Proposed PVS risk management cycle.\u003C/b> Summary of items and procedures required for management of blood products derived from genetic vaccine recipients or those affected with spike protein and modified genes. As with any risk management exercise, it is important to constantly revise policies and procedures as risks and problems are identified. PVS, post-vaccination syndrome.\u003C/div>\n \u003Cdiv class=\"html-img\">\u003Cimg data-large=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png\" data-original=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png\" alt=\"Preprints 107672 g002\" src=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g002.png\">\u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-fig-wrap\" id=\"preprints-107672-f003\">\n \u003Cdiv class=\"html-fig_img\">\n \u003Cdiv class=\"html-figpopup html-figpopup-link\" href=\"#fig_body_display_preprints-107672-f003\">\n \u003Cimg data-large=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png\" data-original=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png\" alt=\"Preprints 107672 g003\" src=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png\">\n \u003Ca class=\"html-expand html-figpopup\" href=\"#fig_body_display_preprints-107672-f003\">\u003C/a>\n \u003C/div>\n\n \u003C/div>\n \u003Cdiv class=\"html-fig_description\">\n \u003Cb>Figure 3.\u003C/b>\n \u003Cb>An example of a system for managing health injuries among genetic vaccine recipients.\u003C/b> Given the global nature of vaccination with genetic vaccines and the movement of vaccine recipients and blood products between countries, an international surveillance network to establish coordination among countries is needed. PVS, post-vaccination syndrome.\n\u003C!-- \u003Cp>\u003Ca class=\"html-figpopup\" href=\"#fig_body_display_preprints-107672-f003\">\n Click here to enlarge figure\n \u003C/a>\u003C/p> -->\n\n \u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-fig_show mfp-hide\" id=\"fig_body_display_preprints-107672-f003\">\n \u003Cdiv class=\"html-caption\"> \u003Cb>Figure 3.\u003C/b>\n \u003Cb>An example of a system for managing health injuries among genetic vaccine recipients.\u003C/b> Given the global nature of vaccination with genetic vaccines and the movement of vaccine recipients and blood products between countries, an international surveillance network to establish coordination among countries is needed. PVS, post-vaccination syndrome.\u003C/div>\n \u003Cdiv class=\"html-img\">\u003Cimg data-large=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png\" data-original=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png\" alt=\"Preprints 107672 g003\" src=\"https://www.preprints.org/frontend/picture/ms_xml/manuscript/37da1875eaf1141b1336b5d3126236b4/preprints-107672-g003.png\">\u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-table-wrap\" id=\"preprints-107672-t001\">\n \u003Cdiv class=\"html-table_wrap_td\">\n \u003Cdiv class=\"html-tablepopup html-tablepopup-link\" href=\"#table_body_display_preprints-107672-t001\">\n \u003Cimg src=\"https://pub.mdpi-res.com/img/table.png\">\n \u003Ca class=\"html-expand html-tablepopup\" href=\"#table_body_display_preprints-107672-t001\">\u003C/a>\n \u003C/div>\n\n \u003C/div>\n \u003Cdiv class=\"html-table_wrap_discription\">\n \u003Cb>Table 1.\u003C/b>\n Major concerns with the use of blood products derived from genetic vaccine recipients.\n \u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-table_show mfp-hide \" id=\"table_body_display_preprints-107672-t001\">\n \n\n \u003Cdiv class=\"html-caption\">\n\u003Cb>Table 1.\u003C/b>\n Major concerns with the use of blood products derived from genetic vaccine recipients.\u003C/div>\n \u003Ctable>\n \u003Cthead>\u003Ctr>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\"> \u003C/th>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\">Concerns\u003C/th>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\">Description\u003C/th>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\">References\u003C/th>\n\u003C/tr>\u003C/thead>\n\u003Ctbody>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">1\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Spike protein contamination\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">The spike protein, which is the antigen of SARS-CoV-2 and genetic vaccines, has already been found to have various toxicities, including effects on red blood cells and platelet aggregation, amyloid formation, and neurotoxicity. It is essential to recognize that the spike protein itself is toxic to humans. It has also been reported that the spike protein can cross the blood–brain barrier. Therefore, it is essential to remove the genetic vaccine-derived spike protein itself from blood products.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B22-preprints-107672\" class=\"html-bibr\">22\u003C/a>,\u003Ca href=\"#B29-preprints-107672\" class=\"html-bibr\">29\u003C/a>,\u003Ca href=\"#B45-preprints-107672\" class=\"html-bibr\">45\u003C/a>,\u003Ca href=\"#B56-preprints-107672\" class=\"html-bibr\">56\u003C/a>,\u003Ca href=\"#B57-preprints-107672\" class=\"html-bibr\">57\u003C/a>,\u003Ca href=\"#B58-preprints-107672\" class=\"html-bibr\">58\u003C/a>,\u003Ca href=\"#B59-preprints-107672\" class=\"html-bibr\">59\u003C/a>,\u003Ca href=\"#B60-preprints-107672\" class=\"html-bibr\">60\u003C/a>,\u003Ca href=\"#B61-preprints-107672\" class=\"html-bibr\">61\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">2\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Contamination with amyloid aggregates and microthrombi formed by spike proteins\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Amyloid aggregation and development of microthrombi formed by the spike proteins into visible thrombi is yet unknown. However, once formed, amyloid aggregates may not be readily cleared and therefore need to be removed from blood products. These amyloid aggregates have been shown to be toxic.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B52-preprints-107672\" class=\"html-bibr\">52\u003C/a>,\u003Ca href=\"#B53-preprints-107672\" class=\"html-bibr\">53\u003C/a>,\u003Ca href=\"#B131-preprints-107672\" class=\"html-bibr\">131\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">3\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Events attributable to decreased donor immune system and immune abnormalities due to immune imprinting or class switch to IgG4, etc., resulting from multiple doses of genetic vaccines\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">In cases where the immune function of a donor is impaired by vaccination with genetic vaccines, there is a risk that the donor might have an (subclinical) infectious disease or has developed viremia or other conditions after being infected with a pathogenic virus, even in the absence of subjective symptoms. Therefore, healthcare professionals who perform surgical procedures, including blood sampling and organ transplantation, as well as use blood products, should exercise caution while handling the blood of genetic vaccine recipients to prevent infections through blood. All healthcare professionals should be informed of these risks.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B64-preprints-107672\" class=\"html-bibr\">64\u003C/a>,\u003Ca href=\"#B65-preprints-107672\" class=\"html-bibr\">65\u003C/a>,\u003Ca href=\"#B66-preprints-107672\" class=\"html-bibr\">66\u003C/a>,\u003Ca href=\"#B67-preprints-107672\" class=\"html-bibr\">67\u003C/a>,\u003Ca href=\"#B68-preprints-107672\" class=\"html-bibr\">68\u003C/a>,\u003Ca href=\"#B71-preprints-107672\" class=\"html-bibr\">71\u003C/a>,\u003Ca href=\"#B72-preprints-107672\" class=\"html-bibr\">72\u003C/a>,\u003Ca href=\"#B73-preprints-107672\" class=\"html-bibr\">73\u003C/a>,\u003Ca href=\"#B74-preprints-107672\" class=\"html-bibr\">74\u003C/a>,\u003Ca href=\"#B75-preprints-107672\" class=\"html-bibr\">75\u003C/a>,\u003Ca href=\"#B76-preprints-107672\" class=\"html-bibr\">76\u003C/a>,\u003Ca href=\"#B81-preprints-107672\" class=\"html-bibr\">81\u003C/a>,\u003Ca href=\"#B82-preprints-107672\" class=\"html-bibr\">82\u003C/a>,\u003Ca href=\"#B83-preprints-107672\" class=\"html-bibr\">83\u003C/a>,\u003Ca href=\"#B84-preprints-107672\" class=\"html-bibr\">84\u003C/a>,\u003Ca href=\"#B85-preprints-107672\" class=\"html-bibr\">85\u003C/a>,\u003Ca href=\"#B87-preprints-107672\" class=\"html-bibr\">87\u003C/a>,\u003Ca href=\"#B88-preprints-107672\" class=\"html-bibr\">88\u003C/a>,\u003Ca href=\"#B89-preprints-107672\" class=\"html-bibr\">89\u003C/a>,\u003Ca href=\"#B90-preprints-107672\" class=\"html-bibr\">90\u003C/a>,\u003Ca href=\"#B91-preprints-107672\" class=\"html-bibr\">91\u003C/a>,\u003Ca href=\"#B92-preprints-107672\" class=\"html-bibr\">92\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">4\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Presence of lipid nanoparticles (LNPs) and pseudouridinated mRNA (mRNA vaccines only)\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">If the blood donated by recipients of mRNA vaccines is collected without a sufficient deferral period after genetic vaccination, LNPs and pseudouridinated mRNA may remain in the blood. LNPs are highly inflammatory and have been found to be thrombogenic, posing a risk to transfusion recipients. Furthermore, LNPs have potent adjuvant activity and pose a risk of inducing Adjuvant-Induced Autoimmune Syndrome (ASIA syndrome). An additional risk is that if the pseudouridinated mRNA is incorporated into the recipient's blood while still packaged in LNPs, further spike protein may be produced in the recipient's body. Additionally, if modified mRNAs persist in the body for a prolonged period of time, they can cause a decrease in immune functions.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B23-preprints-107672\" class=\"html-bibr\">23\u003C/a>,\u003Ca href=\"#B40-preprints-107672\" class=\"html-bibr\">40\u003C/a>,\u003Ca href=\"#B44-preprints-107672\" class=\"html-bibr\">44\u003C/a>,\u003Ca href=\"#B76-preprints-107672\" class=\"html-bibr\">76\u003C/a>,\u003Ca href=\"#B106-preprints-107672\" class=\"html-bibr\">106\u003C/a>,\u003Ca href=\"#B107-preprints-107672\" class=\"html-bibr\">107\u003C/a>,\u003Ca href=\"#B108-preprints-107672\" class=\"html-bibr\">108\u003C/a>,\u003Ca href=\"#B109-preprints-107672\" class=\"html-bibr\">109\u003C/a>,\u003Ca href=\"#B110-preprints-107672\" class=\"html-bibr\">110\u003C/a>,\u003Ca href=\"#B111-preprints-107672\" class=\"html-bibr\">111\u003C/a>,\u003Ca href=\"#B167-preprints-107672\" class=\"html-bibr\">167\u003C/a>,\u003Ca href=\"#B169-preprints-107672\" class=\"html-bibr\">169\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">5\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Contamination with aggregated red blood cells or platelets\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">The spike protein causes red blood cells and platelets to aggregate; these aggregates will be carried into the recipient's blood unless they are physically removed from the blood product before transfusion.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B7-preprints-107672\" class=\"html-bibr\">7\u003C/a>,\u003Ca href=\"#B8-preprints-107672\" class=\"html-bibr\">8\u003C/a>,\u003Ca href=\"#B9-preprints-107672\" class=\"html-bibr\">9\u003C/a>,\u003Ca href=\"#B10-preprints-107672\" class=\"html-bibr\">10\u003C/a>,\u003Ca href=\"#B11-preprints-107672\" class=\"html-bibr\">11\u003C/a>,\u003Ca href=\"#B50-preprints-107672\" class=\"html-bibr\">50\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">6\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Memory B cells producing IgG4 as well as IgG4 produced from them\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Large amounts (serum concentration typically above 1.25–1.4 g/L) of non-inflammatory IgG4-positive plasma cells can cause chronic inflammation, such as fibroinflammatory disease.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B78-preprints-107672\" class=\"html-bibr\">78\u003C/a>,\u003Ca href=\"#B79-preprints-107672\" class=\"html-bibr\">79\u003C/a>,\u003Ca href=\"#B80-preprints-107672\" class=\"html-bibr\">80\u003C/a>,\u003Ca href=\"#B173-preprints-107672\" class=\"html-bibr\">173\u003C/a>,\u003Ca href=\"#B174-preprints-107672\" class=\"html-bibr\">174\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003C/tbody>\n \u003C/table>\n\n\n\n\u003C/div>\n\u003Cdiv class=\"html-table-wrap\" id=\"preprints-107672-t002\">\n \u003Cdiv class=\"html-table_wrap_td\">\n \u003Cdiv class=\"html-tablepopup html-tablepopup-link\" href=\"#table_body_display_preprints-107672-t002\">\n \u003Cimg src=\"https://pub.mdpi-res.com/img/table.png\">\n \u003Ca class=\"html-expand html-tablepopup\" href=\"#table_body_display_preprints-107672-t002\">\u003C/a>\n \u003C/div>\n\n \u003C/div>\n \u003Cdiv class=\"html-table_wrap_discription\">\n \u003Cb>Table 2.\u003C/b>\n Tests needed to confirm the safety of blood products.\n \u003C/div>\n\u003C/div>\n\u003Cdiv class=\"html-table_show mfp-hide \" id=\"table_body_display_preprints-107672-t002\">\n \n\n \u003Cdiv class=\"html-caption\">\n\u003Cb>Table 2.\u003C/b>\n Tests needed to confirm the safety of blood products.\u003C/div>\n \u003Ctable>\n \u003Cthead>\u003Ctr>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\"> \u003C/th>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\">Concerns\u003C/th>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\">Description\u003C/th>\n\u003Cth align=\"center\" valign=\"middle\" style=\"border-top:solid thin;border-bottom:solid thin\" class=\"html-align-center\">References\u003C/th>\n\u003C/tr>\u003C/thead>\n\u003Ctbody>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">1\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Spike protein content in blood\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Immunochemical techniques include enzyme-linked immunosorbent assay, immunophenotyping, mass spectrometry, liquid biopsy, and a combination of liquid biopsy and proteomics. We propose initially conducting mass spectrometry because it can directly measure the protein itself.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B28-preprints-107672\" class=\"html-bibr\">28\u003C/a>,\u003Ca href=\"#B29-preprints-107672\" class=\"html-bibr\">29\u003C/a>,\u003Ca href=\"#B124-preprints-107672\" class=\"html-bibr\">124\u003C/a>,\u003Ca href=\"#B125-preprints-107672\" class=\"html-bibr\">125\u003C/a>,\u003Ca href=\"#B126-preprints-107672\" class=\"html-bibr\">126\u003C/a>,\u003Ca href=\"#B127-preprints-107672\" class=\"html-bibr\">127\u003C/a>,\u003Ca href=\"#B129-preprints-107672\" class=\"html-bibr\">129\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">2\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Spike protein mRNA in blood\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">PCR and/or liquid biopsy are the options. If mRNA for the spike protein is detected, lipid nanoparticles (LNPs) may be present (mRNA vaccines only).\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B127-preprints-107672\" class=\"html-bibr\">127\u003C/a>,\u003Ca href=\"#B128-preprints-107672\" class=\"html-bibr\">128\u003C/a>,\u003Ca href=\"#B130-preprints-107672\" class=\"html-bibr\">130\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">3\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Spike protein DNA in blood\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">PCR and liquid biopsy are the options. This test is necessary because AstraZeneca's viral vector is a DNA vaccine. For mRNA vaccines, it is believed that pseudouridinated mRNA is not reverse transcribed, but this test is required if the spike protein remains in the body for a prolonged period.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B127-preprints-107672\" class=\"html-bibr\">127\u003C/a>,\u003Ca href=\"#B128-preprints-107672\" class=\"html-bibr\">128\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">4\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Autoimmune disorders\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Long-term persistence of the spike protein in the blood increases the risk of autoimmune disease. Therefore, it would be useful to assess for autoimmune disease using antinuclear antibodies as biomarkers in people who are positive for the spike protein, taking into account the results of interviews regarding the subjective symptoms.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B27-preprints-107672\" class=\"html-bibr\">27\u003C/a>,\u003Ca href=\"#B169-preprints-107672\" class=\"html-bibr\">169\u003C/a>,\u003Ca href=\"#B171-preprints-107672\" class=\"html-bibr\">171\u003C/a>,\u003Ca href=\"#B172-preprints-107672\" class=\"html-bibr\">172\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">5\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Post-vaccination syndrome (PVS)\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">A history of vaccination with genetic vaccines and COVID-19, current and previous medical history, and presence of subjective symptoms (e.g., headache, chest pain, shortness of breath, malaise) should be obtained from blood donors and formally recorded. The type of questions included in the interview are critical to facilitate diagnosis and treatment of COVID-19 PVS, as more people are complaining of psychiatric and neurological symptoms after genetic vaccination.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B15-preprints-107672\" class=\"html-bibr\">15\u003C/a>,\u003Ca href=\"#B175-preprints-107672\" class=\"html-bibr\">175\u003C/a>,\u003Ca href=\"#B176-preprints-107672\" class=\"html-bibr\">176\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">6\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Proteins resulting from frameshifting of pseudouridinated mRNA\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Although it is not yet clear whether proteins other than the spike protein are translated from pseudouridinated mRNAs, mass spectrometry may be useful in confirming this.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B166-preprints-107672\" class=\"html-bibr\">166\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">7\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Amyloid aggregates and thrombi\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Common markers of thrombosis, such as D-dimer, should be first used. Once the major components of amyloid aggregates and thrombi have been identified, their use as biomarkers is proposed. Understanding the composition of amyloid aggregates will be important in the future, as amyloid aggregates have been reported to be toxic. Understanding the composition of amyloid aggregates may provide clues to how amyloid is broken down.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B52-preprints-107672\" class=\"html-bibr\">52\u003C/a>,\u003Ca href=\"#B53-preprints-107672\" class=\"html-bibr\">53\u003C/a>,\u003Ca href=\"#B131-preprints-107672\" class=\"html-bibr\">131\u003C/a>,\u003Ca href=\"#B177-preprints-107672\" class=\"html-bibr\">177\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">8\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Origin of spike protein\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">This test will help determine whether the spike protein is from the genetic vaccine or from SARS-CoV-2. Potential candidates include nucleocapsid.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B4-preprints-107672\" class=\"html-bibr\">4\u003C/a>,\u003Ca href=\"#B5-preprints-107672\" class=\"html-bibr\">5\u003C/a>,\u003Ca href=\"#B41-preprints-107672\" class=\"html-bibr\">41\u003C/a>,\u003Ca href=\"#B128-preprints-107672\" class=\"html-bibr\">128\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">9\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Immunosuppression\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">It may be necessary to analyze immunoglobulin subclasses (such as the amount of IgG4) if immunosuppression from multiple doses of the genetic vaccine is a concern.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B71-preprints-107672\" class=\"html-bibr\">71\u003C/a>,\u003Ca href=\"#B72-preprints-107672\" class=\"html-bibr\">72\u003C/a>,\u003Ca href=\"#B73-preprints-107672\" class=\"html-bibr\">73\u003C/a>,\u003Ca href=\"#B74-preprints-107672\" class=\"html-bibr\">74\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">10\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Anti-nucleocapsid antibodies\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">The presence or absence and amount of anti-nucleocapsid antibodies as well as antibody isotypes may be an indicator(s) for distinguishing whether these are caused by genetic vaccines or long COVID.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B141-preprints-107672\" class=\"html-bibr\">141\u003C/a>,\u003Ca href=\"#B142-preprints-107672\" class=\"html-bibr\">142\u003C/a>,\u003Ca href=\"#B143-preprints-107672\" class=\"html-bibr\">143\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003Ctr>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">11\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Others\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">Occurrence of myocarditis and pericarditis after genetic vaccination has been reported in various countries. Therefore, those with subjective symptoms should also be assessed for myocarditis markers, such as cardiac troponin T.\u003C/td>\n\u003Ctd align=\"center\" valign=\"middle\" style=\"border-bottom:solid thin\" class=\"html-align-center\">[\u003Ca href=\"#B18-preprints-107672\" class=\"html-bibr\">18\u003C/a>,\u003Ca href=\"#B19-preprints-107672\" class=\"html-bibr\">19\u003C/a>,\u003Ca href=\"#B29-preprints-107672\" class=\"html-bibr\">29\u003C/a>,\u003Ca href=\"#B144-preprints-107672\" class=\"html-bibr\">144\u003C/a>,\u003Ca href=\"#B178-preprints-107672\" class=\"html-bibr\">178\u003C/a>,\u003Ca href=\"#B179-preprints-107672\" class=\"html-bibr\">179\u003C/a>]\u003C/td>\n\u003C/tr>\n\u003C/tbody>\n \u003C/table>\n\n\n\n\u003C/div>\n\u003C/section>\u003Csection class=\"html-fn_group\">\u003Ctable>\u003Ctr id>\n\u003Ctd>\u003C/td>\n\u003Ctd>\u003Cdiv class=\"html-p\">\n\u003Cb>Disclaimer/Publisher’s Note:\u003C/b> The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.\u003C/div>\u003C/td>\n\u003C/tr>\u003C/table>\u003C/section>\n \u003Csection id=\"html-copyright\">\u003Cbr>© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (\u003Ca href=\"https://creativecommons.org/licenses/by/4.0/\" target=\"_blank\">https://creativecommons.org/licenses/by/4.0/\u003C/a>).\u003C/section>\n ",[202,204],{"version":126,"hash_key":128,"id":127,"change":203},"\u003Cp>It was sent for English editing to make it easier to read. Some of the information has also been updated with additional references and figures. The story has not changed significantly.\u003C/p>",{"version":7,"hash_key":205,"id":127,"change":50},"681a042c115b144bb36fa7675bbbae20","Ueda, J.; Motohashi, H.; Hirai, Y.; Yamamoto, K.; Murakami, Y.; Fukushima, M.; Fujisawa, A. Transfusions of Blood Products Derived from Genetic Vaccine Recipients: Safety Concerns and Proposals for Specific Measures. \u003Cem>Preprints\u003C/em> \u003Cb>2024\u003C/b>, 2024030881. https://doi.org/10.20944/preprints202403.0881.v2",[208],{"version":126,"change":203},[],{"code":41,"msg":42,"data":211},[212,216],{"id":7,"name":213,"image":214,"url":215,"statistic_type":7},"Author Services","https://www.preprints.org/media/cache/resolve/webp/upload/banner/2024-10-30/c8ecd3b8b0ebf1abcd96d37f5ee4a609.jpeg","https://www.mdpi.com/authors/english?utm_source=preprintsweb&utm_medium=banner&utm_campaign=AS_High-quality",{"id":217,"name":218,"image":219,"url":220,"statistic_type":50},3,"award","https://www.preprints.org/media/cache/resolve/webp/upload/banner/2024-10-30/58bbc3b8f7c90f2eab7ce32d00691421.jpeg","https://www.preprints.org/activity/award/announcement?utm_source=ArticlePage&utm_medium=Banner&utm_campaign=award",{"code":41,"msg":42,"data":222},{"rows":223,"total":41},[],{"code":41,"msg":42,"data":225},[226,245,273,298,320,336,379,410,444,463],{"doi":227,"title":228,"url":229,"authors":230,"published_at":243,"journal_name":50,"click_trigger_url_hash":244},"10.20944/preprints202404.1703.v1","Risk of Blood Clots After COVID-19 Vaccination and Infection: A Risk-Benefit Analysis","https://doi.org/10.20944/preprints202404.1703.v1",[231,234,237,240],{"name":232,"email":233},"Huong NQ Tran","huong.tran2@corewellhealth.org",{"name":235,"email":236},"Malcolm Risk","mhrisk@umich.edu",{"name":238,"email":239},"Girish B Nair","girish.nair@corewellhealth.org",{"name":241,"email":242},"Lili Zhao","lili.zhao@corewellhealth.org","2024-04-26","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfiTMJmd1FCzr93WpSIkxkSOYXdcEHcNNW50uZJPV2M-O-4I0i7QHcV01qbqNhX8PNw",{"doi":246,"title":247,"url":248,"authors":249,"published_at":271,"journal_name":50,"click_trigger_url_hash":272},"10.20944/preprints202110.0404.v1","The 4-Year Experience with Implementation and Routine Use of Pathogen Inactivation in a Brazilian Hospital","https://doi.org/10.20944/preprints202110.0404.v1",[250,253,256,259,262,265,268],{"name":251,"email":252},"Roberta Maria Fachini","fachinir@ihsl.com.br",{"name":254,"email":255},"Rita Fontão-Wendel","rita.f.wendel@terra.com.br",{"name":257,"email":258},"Ruth Achkar","achkarr@ihsl.com.br",{"name":260,"email":261},"Patrícia Scuracchio","scuracchiop@ihsl.com.br",{"name":263,"email":264},"Mayra Brito","britom@ihsl.com.br",{"name":266,"email":267},"Marcelo Amaral","amaralm@ihsl.com.br",{"name":269,"email":270},"Silvano Wendel","snwendel@terra.com.br","2021-10-27","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfgc1Sxwa7o3c6myRxD_FSd-4FgKbn4SBU0gcyKhaEzg3YeOldLYWODqYXgUoIPXkmw",{"doi":274,"title":275,"url":276,"authors":277,"published_at":296,"journal_name":50,"click_trigger_url_hash":297},"10.20944/preprints202206.0080.v1","The Frequency and Patterns of Post-COVID-19 Vaccination Syndrome Reveal Initially Mild and Potentially Immunocytopenic Signs in Primarily Young Saudi Women","https://doi.org/10.20944/preprints202206.0080.v1",[278,281,284,287,290,293],{"name":279,"email":280},"Kamaleldin B. Said","kbs.mohamed@uoh.edu.sa",{"name":282,"email":283},"Amal Al-Otaibi","s201806142@uoh.edu.sa",{"name":285,"email":286},"Luluh Aljaloud","s201803639@uoh.edu.sa",{"name":288,"email":289},"Basmah Al-Anazi","s201800476@uoh.edu.sa",{"name":291,"email":292},"Ahmed Alsolami","a.alsolami@uoh.edu.sa",{"name":294,"email":295},"Fayez Saud Alreshidi","fs.alreshidi@uoh.edu.sa","2022-06-06","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfqdE9ZEukn49utUga4EiCqGXGSE350N3FspdEtWEZEGmcJQVdnrDw36Jl4wAH_D4wA",{"doi":299,"title":300,"url":301,"authors":302,"published_at":318,"journal_name":50,"click_trigger_url_hash":319},"10.20944/preprints202204.0272.v1"," Silent Antibodies Start Talking: Enhanced Lateral Flow Serodiagnosis with Two-Stage Incorporation of Labels into Immune Complexes ","https://doi.org/10.20944/preprints202204.0272.v1",[303,306,309,312,315],{"name":304,"email":305},"Dmitriy V. Sotnikov","sotnikov-d-i@mail.ru",{"name":307,"email":308},"Nadezhda A. Byzova","nbyzova@mail.ru",{"name":310,"email":311},"Anatoly V. Zherdev","zherdev@inbi.ras.ru",{"name":313,"email":314},"Youchun Xu","xyc2012@mail.tsinghua.edu.cn",{"name":316,"email":317},"Boris B. Dzantiev","dzantiev@inbi.ras.ru","2022-04-28","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfs9V4xG_h0ZZ9f-k2jlh02XrEn4PuK7H3RmQRZkEcibJfJyljFKC_NvL8vxLEijr8w",{"doi":321,"title":322,"url":323,"authors":324,"published_at":334,"journal_name":50,"click_trigger_url_hash":335},"10.20944/preprints202209.0114.v1","Assessment of Knowledge, Attitude, and Practice toward Blood Transfusion among Healthcare Providers in Qatar","https://doi.org/10.20944/preprints202209.0114.v1",[325,328,331],{"name":326,"email":327},"Danial Hassan","dhussain@moph.gov.qa",{"name":329,"email":330},"Abdulqadir J Nashwan","anashwan@hamad.qa",{"name":332,"email":333},"Mohamed Yassin","yassin@hamad.qa","2022-09-08","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfvRlFCR15QjSwfkDuMsiAfj2liWoOOl1H6rpAlPDth2r9jtUdlY3PkcWzcN3eigl_A",{"doi":337,"title":338,"url":339,"authors":340,"published_at":377,"journal_name":50,"click_trigger_url_hash":378},"10.20944/preprints202310.0194.v1","SARS-CoV-2 Impact on Red Blood Cell Morphology","https://doi.org/10.20944/preprints202310.0194.v1",[341,344,347,350,353,356,359,362,365,368,371,374],{"name":342,"email":343},"Kirill Kondratov","kondratovk.kirill@yandex.ru",{"name":345,"email":346},"Alexander Artamonov","artamonov.alandr@yandex.ru",{"name":348,"email":349},"Vladimir Mikhailovskii","v.mikhailovskii@gmail.com",{"name":351,"email":352},"Anastasiya Velmiskina","velmiskina96@mail.ru",{"name":354,"email":355},"Sergey Mosenko","neurologist@mail.ru",{"name":357,"email":358},"Evgeniy Grigoryev","grigoryev_egeniy@mail.ru",{"name":360,"email":361},"Anna Anisenkova","anna_anisenkova@list.ru",{"name":363,"email":364},"Yuri Nikitin","dr.iuriinikitin@gmail.com",{"name":366,"email":367},"Svetlana Apalko","svetlana.apalko@gmail.com",{"name":369,"email":370},"Natalya Sushentseva","natalia@sushentseva.ru",{"name":372,"email":373},"Andrey Ivanov","iamvma@mail.ru",{"name":375,"email":376},"Sergey Shcherbak","sgsherbak@mail.ru","2023-10-04","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfsFJq6YP1OdtEFvV46Z13F-yTCYNpkMIsLAUMu2-bJIxnoddE29oQm0hzpSw1g79RQ",{"doi":380,"title":381,"url":382,"authors":383,"published_at":408,"journal_name":50,"click_trigger_url_hash":409},"10.20944/preprints202304.1094.v1","Effects of Different Types of Recombinant SARS-CoV-2 Spike Protein on Circulating Monocytes Structure","https://doi.org/10.20944/preprints202304.1094.v1",[384,387,390,393,396,399,402,405],{"name":385,"email":386},"Marco Vettori","marco.vettori@studenti.univr.it",{"name":388,"email":389},"Francesco Dima","francesco.dima@aovr.veneto.it",{"name":391,"email":392},"Brandon Michael Henry","brandon.henry@cchmc.org",{"name":394,"email":395},"Giovanni Carpenè","giovanni.carpene@studenti.univr.it",{"name":397,"email":398},"Matteo Gelati","matteo.gelati@univr.it",{"name":400,"email":401},"Giovanni Celegon","giovanni.celegon@studenti.univr.it",{"name":403,"email":404},"Gianluca Salvagno","gianluca.salvagno@univr.it",{"name":406,"email":407},"Giuseppe Lippi","giuseppe.lippi@univr.it","2023-04-28","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfpVQ7MY1baOGWh9kNNtBGLwl78B3s1TBAwLfGbtcmYwKtTNjuoMpe7vuAq8RH17J-Q",{"doi":411,"title":412,"url":413,"authors":414,"published_at":442,"journal_name":50,"click_trigger_url_hash":443},"10.20944/preprints202211.0498.v1","SARS-CoV-2 Virus-Like Particles (VLPs) specifically detect humoral immune reactions in an ELISA based platform","https://doi.org/10.20944/preprints202211.0498.v1",[415,418,421,424,427,430,433,436,439],{"name":416,"email":417},"Stefan Hirschberg","stefan.hirschberg@charite.de",{"name":419,"email":420},"Hannes Bauer","bauer.hannes.jr@gmail.com",{"name":422,"email":423},"Julian Kamhieh-Milz","jkm@dhs-lab.de",{"name":425,"email":426},"Frauke Ringel","frauke.ringel@wimedko.com",{"name":428,"email":429},"Christoph Harms","christoph.harms@charite.de",{"name":431,"email":432},"Omar Kamal Eddin","oke@wimedko.com",{"name":434,"email":435},"Axel Pruß","axel.pruss@charite.de",{"name":437,"email":438},"Katja Hanack","katja.hanack@uni-potsdam.de",{"name":440,"email":441},"Kai Schulze-Forster","schufo@celltrend.de","2022-11-28","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfpHdQkQhDQ8oPSNxN1Xn6V6fZMwbcOOsJXWPVr0MTfztalL5I-oT7y8hmfYMvXwIqw",{"doi":445,"title":446,"url":447,"authors":448,"published_at":461,"journal_name":50,"click_trigger_url_hash":462},"10.20944/preprints202306.0473.v1","Effects of COVID-19 infection in healthy subjects on cardiac function and biomarker of oxygen transport, blood coagulation and inflammation","https://doi.org/10.20944/preprints202306.0473.v1",[449,452,455,458],{"name":450,"email":451},"Nadezhda G. Gumanova","gumanova@mail.ru",{"name":453,"email":454},"Alexander Gorshkov","agorshkov@gnicpm.ru",{"name":456,"email":457},"Natalya L Bogdanova","nlbogdanova@gnicpm.ru",{"name":459,"email":460},"Andrei I Korolev","akorolev@gnicpm.ru","2023-06-07","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfilzGqTTiIFJf9YdUBFb_4jWxBqcQltQ-Rjbbg4nsYgIUe00IEWAJirp8uvM38UPng",{"doi":464,"title":465,"url":466,"authors":467,"published_at":498,"journal_name":50,"click_trigger_url_hash":499},"10.20944/preprints202306.0264.v1","The Coagulation Profile Monitoring of COVID-19 Patients with Standard and Viscoelastic Point of Care Hemostasis Tests","https://doi.org/10.20944/preprints202306.0264.v1",[468,471,474,477,480,483,486,489,492,495],{"name":469,"email":470},"Milan Lazarević","dr_m.lazarevic@hotmail.com",{"name":472,"email":473},"Natalija Vuković","massha.vukovic@gmail.com",{"name":475,"email":476},"Dragan Milic","drdaganmilic@gmail.com",{"name":478,"email":479},"Aleksandar Kamenov","kamenovcs@gmail.com",{"name":481,"email":482},"Velimir Peric","velperic@gmail.com",{"name":484,"email":485},"Mladan Golubovic","mladjangolubovic@gmail.com",{"name":487,"email":488},"Dimitrije Spasic","dspasic@lec.edu",{"name":490,"email":491},"Vladimir Stojiljkovic","serbvlada@gmail.com",{"name":493,"email":494},"Marija Stosic","marija91nis@gmail.com",{"name":496,"email":497},"Dragana Stokanovic","dragana.stokanovic@medfak.ni.ac.rs","2023-06-05","6NDYF0rWYbBywNc0fWBhIR_LM-Lo0aEBMAFDd6KOeJaQX28ooemMJIsFhCW0_w0QDBAOPogDoZkeVmCoY2uPfh7FHPwqYyOR_pAvGGinikaIlqWg_PzMQCO0jdWa6kPF0kbtW0DkqGiOE1wlNBlaWA",["Reactive",501],{"$scookieConsent":502,"$stoast-ui":503,"$ssite-config":505},{"necessary":6,"functional":133,"statistic":133,"marketing":133,"unclassified":133},{"showToast":133,"toastMessage":159,"toastVariant":504},"neutral",{"env":506,"name":507,"url":508},"production","nuxt-app","http://frontend.preprints.org/",["Set"],["ShallowReactive",511],{"PlVuOumUsI":50,"mgOlEjP40X":50,"Ya7hZzqdE7":50,"V2IvscPMVh":50,"JoG0wWOyMK":50,"6gTy2KwK9d":50},"/manuscript/202403.0881/v2",["Reactive",514],{"auth":515,"share-modal":517,"useHeader":518},{"userInfo":516,"isLogin":133},{},{"isShareModalOpen":133,"item":50},{"height":41}]</script> <script>window.__NUXT__={};window.__NUXT__.config={public:{turnstile:{siteKey:"0x4AAAAAAAeRafIKjAzYS6R5"},strapiUrl:"",blog:"https://preprintsblog.wordpress.sciforum.net",envData:{USER:"www-data",SSH_CLIENT:"10.10.0.129 56114 22",npm_config_user_agent:"npm/8.19.2 node/v18.10.0 linux x64 workspaces/false",npm_node_execpath:"/usr/local/node/bin/node",CURRENT_USER:"weijun.yu@mdpi.com",SHLVL:"2",npm_config_noproxy:"",MOTD_SHOWN:"pam",HOME:"/home/www",OLDPWD:"/home/www",npm_package_json:"/var/www/sciprints.net-frontend/package.json",npm_config_userconfig:"/home/www/.npmrc",npm_config_local_prefix:"/var/www/sciprints.net-frontend",COLOR:"0",npm_config_metrics_registry:"https://registry.npmjs.org/",LOGNAME:"www-data",_:"/usr/bin/npm",npm_config_prefix:"/usr/local/node",npm_config_cache:"/home/www/.npm",npm_config_node_gyp:"/usr/local/node/lib/node_modules/npm/node_modules/node-gyp/bin/node-gyp.js",PATH:"/var/www/sciprints.net-frontend/node_modules/.bin:/var/www/node_modules/.bin:/var/node_modules/.bin:/node_modules/.bin:/usr/local/node/lib/node_modules/npm/node_modules/@npmcli/run-script/lib/node-gyp-bin:/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/usr/games:/usr/local/games:/snap/bin",NODE:"/usr/local/node/bin/node",npm_package_name:"nuxt-app",LANG:"en_US.UTF-8",PACFILE:".pac/config-prod.sh",npm_lifecycle_script:"nuxt build --logLevel=silent",SHELL:"/bin/bash",npm_lifecycle_event:"build",npm_config_globalconfig:"/usr/local/node/etc/npmrc",npm_config_init_module:"/home/www/.npm-init.js",PWD:"/var/www/sciprints.net-frontend",npm_execpath:"/usr/local/node/lib/node_modules/npm/bin/npm-cli.js",SSH_CONNECTION:"10.10.0.129 56114 10.1.0.124 22",npm_config_global_prefix:"/usr/local/node",npm_command:"run-script",INIT_CWD:"/var/www/sciprints.net-frontend",EDITOR:"vi",NODE_ENV:"production",NUXT_USING_SSR:"true",NUXT_APP_URL:"https://www.preprints.org",NUXT_LOGIN_URL:"/login",NUXT_IDP_URL:"https://login.mdpi.com",NUXT_FIREBASE_API_KEY:"AIzaSyAyKu1mWkkTnfv7HtCQcptOymDZ1w4Jzy0",NUXT_FIREBASE_AUTH_DOMAIN:"preprints-b6f4b.firebaseapp.com",NUXT_FIREBASE_PROJECT_ID:"preprints-b6f4b",NUXT_FIREBASE_STORAGE_BUCKET:"preprints-b6f4b.appspot.com",NUXT_FIREBASE_MESSAGING_SENDER_ID:"369406057228",NUXT_FIREBASE_APP_ID:"1:369406057228:web:4be3e02b94bc45be260729",NUXT_PUBLIC_TURNSTILE_SITE_KEY:"0x4AAAAAAAeRafIKjAzYS6R5",NUXT_PUBLIC_BLOG:"https://preprintsblog.wordpress.sciforum.net",NUXT_BLOG_USER:"lloyd.shu@mdpi.com",NUXT_BLOG_TOKEN:"B0K6 kfJs bPsY gVWZ ELn2 J6yw",NUXT_PUBLIC_SENTRY_DSN:"https://4594052328229da018023f50bcd17eb8@o4506621248798720.ingest.us.sentry.io/4508131538960384",NUXT_PUBLIC_SENTRY_ENVIRONMENT:"production"},gtm:{devtools:true,id:"GTM-NX2CT4D"},sentry:{dsn:"https://4594052328229da018023f50bcd17eb8@o4506621248798720.ingest.us.sentry.io/4508131538960384",environment:"production"},nuxtHighcharts:{pluginOptions:{},hcMods:["accessibility","annotations-advanced","annotations","arc-diagram","arrow-symbols","boost-canvas","boost","broken-axis","bullet","coloraxis","current-date-indicator","cylinder","data-tools","data","datagrouping","debugger","dependency-wheel","dotplot","drag-panes","draggable-points","drilldown","dumbbell","export-data","exporting","flowmap","full-screen","funnel","funnel3d","gantt","geoheatmap","grid-axis","heatmap","heikinashi","histogram-bellcurve","hollowcandlestick","item-series","lollipop","map","marker-clusters","mouse-wheel-zoom","navigator","networkgraph","no-data-to-display","offline-exporting","organization","overlapping-datalabels","parallel-coordinates","pareto","pathfinder","pattern-fill","pictorial","price-indicator","pyramid3d","sankey","series-label","series-on-point","solid-gauge","sonification","static-scale","stock-tools","stock","streamgraph","sunburst","tiledwebmap","tilemap","timeline","treegraph","treegrid","treemap","variable-pie","variwide","vector","venn","windbarb","wordcloud","xrange"]},cookieConsent:{consentMode:true,consentModeDefaults:true,provider:"cookiebot",init:true,dev:false,scripts:{necessary:[],functional:[],statistic:[],marketing:[],unclassified:[]},cbid:"6b5b25c6-89f0-4619-834a-8af9d1157dc1"},strapi:{url:"http://localhost:1337",prefix:"/api",admin:"/admin",version:"v4",cookie:{},auth:{},cookieName:"strapi_jwt",devtools:false}},app:{baseURL:"/",buildId:"665f035c-6c69-41d6-996d-1cf3ec9234e7",buildAssetsDir:"/_nuxt/",cdnURL:""}}</script></body></html>