Bioconjugation | Biosynth

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Spend over $250 to avoid the minimum order surcharge.</b> </div> <div id="min-order-top" class="min-order-top" style="display: none;"> <b><i class="fa fa-exclamation-circle"></i> Spend over $250 to avoid a minimum order surcharge</b> | Cart Total: $<span id="min-order-notification-total"></span> </div> </div> </header> <section class="content">  <header class="py-13 jarallax" data-jarallax data-speed=".8" style="background-image: url('https://www.biosynth.com//uploads/Page%20Headers/Bioconjugation%20Header.jpg');"> <div class="container"> <div class="row"> <div class="col-12"> <h1 class="text-white">Bioconjugation</h1> <h2 class="text-white h5">Development and manufacturing of bioconjugate drugs. Custom bioconjugation services, from concept to GMP production.</h2> </div> </div> </div> </header> <div class="usercontent">  <section class="py-7"> <div class="container"> <div class="row justify-content-center"> <div class="col-12 col-md-10X no-flex"> <p>Biosynth pioneers advanced bioconjugate drugs, conjugate vaccines, and polymer innovations for pharmaceutical needs. Our comprehensive services span from developing tailored PEGylated biomolecules and conjugate vaccines to crafting specialized polymers and activating PEGs, complemented by cutting-edge multimerization technologies, empowering advancements in drug delivery and biomolecule analysis.<br /><br /><span>Find out more about all of our services through the links below. </span></p> <div class="row"> <div class="col-12 col-sm-6"> <div class="bio-btn h-100"> <div class="darkblue"> <h3><a href="/bioconjugation/services">Bioconjugation Services</a></h3> <a href="/bioconjugation/services">find out more</a></div> </div> </div> <div class="col-12 col-sm-6"> <div class="bio-btn h-100"> <div class="darkblue"> <h3><a href="/bioconjugation/services/manufacturing">Bioconjugates and Polymers Manufacturing Services</a></h3> <a href="/bioconjugation/services/manufacturing">find out more</a></div> </div> </div> </div> <div class="row"> <div class="col-12 col-sm-6"> <div class="bio-btn h-100"> <div class="darkblue"> <h3><a href="/chemicals/functionalized-polymers">Polymer Chemistry</a></h3> <a href="/chemicals/functionalized-polymers">find out more</a></div> </div> </div> <div class="col-12 col-sm-6"> <div class="bio-btn h-100"> <div class="darkblue"> <h3><a href="/biologics/analytics">Analysis of Biomolecules and Bioconjugates</a></h3> <a href="/biologics/analytics">find out more</a></div> </div> </div> </div> <br /> <h2>Bioconjugation Applications</h2> <p>Bioconjugation is the covalent linkage of a biological molecule, such as a protein, peptide, or oligonucleotide, to a synthetic molecule. This process can create new molecules with novel properties, such as increased stability, improved targeting, or the ability to deliver drugs or other therapeutic agents to specific cells or tissues. Bioconjugation is a powerful tool that is used in a wide range of applications, including:<br /><br /></p> <ul> <li><strong>Drug development:</strong> Bioconjugation can create new drug conjugates that are more effective and less toxic than traditional drugs. For example, antibody-drug conjugates (ADCs) are a type of bioconjugate that combines the targeting specificity of antibodies with the cytotoxic activity of chemotherapy drugs.</li> <li><strong>Diagnostics:</strong> Bioconjugation can be used to create new diagnostic probes and imaging agents that can be used to detect and image diseases at an early stage. For example, bioconjugated probes can detect cancer biomarkers, Alzheimer's disease, and other diseases.</li> <li><strong>Gene therapy:</strong> Bioconjugation can deliver gene therapy vectors to specific cells or tissues. This can treat genetic diseases, cancer, and other conditions, such as Duchenne muscular dystrophy (DMD).</li> <li><strong>Materials science:</strong> Bioconjugation can create new biomaterials with novel properties. Bioconjugated materials can be used to create implantable devices, tissue engineering scaffolds, and drug delivery systems.</li> </ul> <p><img src="/uploads/Pages/Bioconjugation/types%20of%20bioconjugates.png" width="1000" height="234" caption="false" alt="Examples of Bioconjugates" /></p> <p style="text-align: center;"><span style="color: #999999;">Example of different types of bioconjugates.</span></p> <p style="text-align: center;"></p> <p style="text-align: center;"><a href="/bioconjugation/services" class="btn btn-primary btn-sm">Find out more.</a></p> <br /> <h2>Biosynth's Manufacturing Capabilities</h2> <p>Our state-of-the-art manufacturing facility in Berlin is equipped to produce high-quality bioconjugates in a variety of scales. As a leading bioconjugation services and solutions provider, our team has extensive expertise in developing and manufacturing bioconjugates, including ADCs, conjugate vaccines, and other bioconjugate-based products. We can develop and perform bioconjugation processes from µg to multi-gram scale while using state-of-the-art equipment. Our services range from early development to the manufacture of an investigational medicinal product (IMP) / drug substance for first clinical trials in humans.</p> <p>We offer a wide range of bioconjugation services, including:</p> <ul> <li><strong>Bioconjugation Process Development</strong>. Our team of experienced scientists can optimize the bioconjugation process for each molecule to ensure the highest possible yield to help customers develop bioconjugation processes for new or existing products.<br /><br /></li> <li><strong>Bioconjugate Manufacturing</strong>. We can manufacture bioconjugates for preclinical and clinical trials and commercial production. Our equipment permits us to deliver high-quality bioconjugates in a variety of scales, as well as GMP manufacturing of bioconjugates.<br /><br /></li> <li><strong>Analytical Services for Bioconjugates</strong>. Our comprehensive range of analytical services for bioconjugates includes characterization, potency testing, and stability testing. We provide custom analytical services to meet the specific needs of our customers. <a href="/biologics/analytics">Read more about our biomolecule analysis services.</a><br /><br /></li> </ul> <p>We also offer a variety of other services, such as the synthesis of small molecules and polymers, and the development and manufacturing of specialty polymers.</p> <br /> <p><img src="/uploads/Pages/Bioconjugation/Reactor%20Bioconjugation%202.jpg" width="500" height="334" caption="false" alt="Biosynth Bioconjugation Reactor" style="display: block; margin-left: auto; margin-right: auto;" /></p> <p style="text-align: center;"><a href="/chemicals/functionalized-polymers" class="btn btn-primary btn-sm">Find out more about our services for Polymer Chemistry</a></p> <p style="text-align: center;"><a href="/contact-us/pharma-services/all-custom-services?topic=Bioconjugate%20Development%20or%20Manufacturing" class="btn btn-primary btn-sm">Contact us to find out more</a></p> <p><span> </div> </div> </div> </section> <section class="bg-light-50 my-6 home-news usercontent"> <div class="container"> <div class="row"> <div class="col-12 bg-light py-7"> <div class="r-bioicon"></div> </span></p> <h3>Embark on a bioconjugation journey powered by Biosynth.</h3> <p>Biosynth excels in developing a diverse library of bioconjugates. </p> <ul> <li><span class="cf0">Antigen-conjugated carrier proteins - so-called conjugate vaccines that enable vaccination against poorly immunogenic antigens</span></li> <li>Liposome-drug conjugates facilitate controlled and targeted drug delivery.</li> <li>Enzyme-substrate conjugates enable sensitive enzyme assays</li> <li>Fluorescent protein fusions, which aid molecular biologists in tracking protein localization </li> </ul> <p>Biosynth's expertise in PEGylation enhances the stability and circulation of therapeutic proteins and protein-antigen conjugates crucial for immunization studies. </p> <p><span></div> </div> </div> </section> <section class="pt-5 usercontent"> <div class="container"> <div class="row no-flex"> <div class="col-12"></span></p> <h3>Type of Bioconjugation Reactions and Synthetic Procedure</h3> <p>Many different types of bioconjugation reactions can be used to link biological molecules to synthetic molecules. Some of the most common types of bioconjugation reactions are:<br /><br /></p> <ul> <li>Amide bond formation: this is the most common type of bioconjugation reaction. It links peptides and proteins to various synthetic molecules, such as drugs, linkers, and imaging agents.</li> <li>Thiol-maleimide coupling: this rapid and efficient coupling is often used to link antibodies and other proteins to drugs and other therapeutic agents.</li> <li>Click chemistry: this versatile type of bioconjugation reaction can link a wide variety of molecules together. It is often used to create bioconjugates with complex structures.<br /><br /></li> </ul> <p>The synthesis of bioconjugates is challenging, and the synthetic procedure varies depending on the molecules involved and the desired properties of the final product. However, some general steps are common to most bioconjugation syntheses:<br /><br /></p> <ol> <li> <p>Choose a biomolecule for conjugation.</p> </li> <li> <p>Functionalize the biomolecule. This includes the modification and activation of the biomolecule's functional groups.</p> </li> <li> <p>Prepare the synthetic molecule.</p> <p>a. Create the synthetic molecule with the desired functionality.</p> <p>b. Activate the synthetic molecule's functional groups.</p> </li> <li> <p>Combine the activated biomolecule and the synthetic molecule under suitable conditions (mix and conjugate).</p> </li> <li> <p>Purify the bioconjugate to remove impurities and unreacted molecules, followed by its characterization to confirm the identity and purity of the bioconjugate.</p> <p></p> </li> </ol> <p>Further steps can include stability and bioactivity testing, stability formulation, and scale-up if required.</p> <p></p> <h3>Polyethylene glycol (PEG) as a versatile Bioconjugation linker</h3> <p>Polyethylene glycol or PEG is indispensable in the field of bioconjugation. It is the most versatile linker for this purpose, offering a range of benefits that enhance bioconjugates. PEG products serve as a linchpin for improving their safety and efficacy, making them the go-to choice for numerous applications in biopharmaceuticals and drug delivery systems.</p> <p>The key points of PEG are:</p> <p><span>✓ </span><strong>Biocompatibility</strong>. PEG is highly biocompatible and minimizes the risk of immune responses, making it suitable for conjugation with various biomolecules.<br /><span>✓ </span><strong>Solubility Enhancement</strong>. PEG's hydrophilic nature improves the solubility of hydrophobic molecules, crucial for drug delivery.<br /><span>✓ </span><strong>Steric Hindrance</strong>. PEG's long, flexible chain structure creates steric hindrance, preventing non-specific interactions for enhanced selectivity.<br /><span>✓ </span><strong>Improved Pharmacokinetics</strong>: PEGylation extends the circulation time of bioconjugates which leads to a more sustained therapeutic effect.<br /><span>✓ </span><strong>Versatile Chemistry</strong>. Multiple functionalization options with various end-groups for better and precise control over conjugation chemistry.<br /><span>✓ </span><strong>Reduction of Aggregation</strong>. PEGylation reduces the aggregation of biomolecules, crucial for biopharmaceuticals and drug formulation.<br /><span>✓ </span><strong>Controlled Release</strong>. PEG can be used as a linker for controlled drug release, improving bioavailability and reducing side effects.</p> <p><br /><img src="/uploads/Pages/Bioconjugation/PEG%20building%20block.png" alt="Polyethylene Glycol PEG monomer" width="333" height="131" caption="false" style="display: block; margin-left: auto; margin-right: auto;" /></p> <p style="text-align: center;"><span color="#999999">Polyethylene Glycol (PEG) monomer.</span></p> <p><br /><br /><br />PEG products play a pivotal role in bioconjugation. Its versatility has established PEG as an essential tool in the development of biopharmaceuticals and drug delivery systems, driving advancements in a range of scientific and medical applications. </p> <p style="text-align: center;"><a href="/category/peg-products" class="btn btn-primary btn-sm">Find out more about our PEG products</a>          <a href="/contact-us/pharma-services/all-custom-services?topic=Bioconjugate%20Development%20or%20Manufacturing" class="btn btn-primary btn-sm">Contact us for more information</a></p> <p></p> <p><span> </div> </div> </div> </section> <section class="bsy-pattern bsy-pattern-cyan my-7"> <div class="container"> <div class="row"> <div class="col-xs-12">  </span></p> <h3>Importance of Bioconjugation <span></div> </div> </div> </section> <section class="usercontent"> <div class="container"> <div class="row no-flex"> <div class="div class="col-12"></span></h3> <p>Bioconjugation is important because it allows us to create new molecules with properties that cannot be achieved with traditional synthetic chemistry. For example, bioconjugation can be used to create molecules that are:<br /><br /></p> <ul> <li><strong>More stable:</strong> Bioconjugation can attach stabilizing groups to biological molecules, such as proteins and peptides. This can improve the shelf life and stability of these molecules in vivo.</li> <li><strong>More targetable:</strong> Bioconjugation can attach targeting ligands to biological molecules. This allows the molecules to be delivered specifically to specific cells or tissues.</li> <li><strong>More potent:</strong> Bioconjugation can attach cytotoxic or other therapeutic agents to biological molecules. This can create new drug conjugates that are more potent and selective than traditional drugs.<br /><br /></li> </ul> <br /> <h3>Pharmacokinetics and Pharmacodynamics </h3> <p>Pharmacodynamics (PD) and pharmacokinetics (PK) are fundamental disciplines in the study of bioconjugates. Both stand as fundamental pillars in the exploration of bioconjugates, playing a pivotal role in understanding their intricate behavior and unlocking their vast therapeutic potential. They are closely interwoven, forming the cornerstone of bioconjugate research. <strong>Pharmacodynamics</strong> probes the intricate bioconjugate <strong>interactions with specific biological targets</strong>, shedding light on molecular recognition and the orchestration of therapeutic responses. Meanwhile, <strong>pharmacokinetics</strong> delves into the <strong>bioconjugate's journey within the body</strong>, covering aspects like absorption, distribution, metabolism, and elimination. This comprehensive understanding of PD and PK goes beyond mere information; it acts as a catalyst for precise design, dosing strategies, and critical safety assessments necessary for the clinical application of bioconjugates. Through a scientific lens, it becomes evident that bioconjugates play vital roles in drug delivery, diagnostics, and the forefront of therapeutic innovation, while their fine-tuning for enhanced search engine visibility underscores their substantial significance.</p> <br /> <h3>Pharmacodynamics (PD)</h3> <p>It is important to examine bioconjugate interactions with highly specific biological targets. This deep and methodical exploration unveils the intricate dynamics of molecular recognition, binding affinities, and the orchestration of therapeutic responses. Within this intricate dance at the molecular level, researchers can discern the profound impact bioconjugates have on the biological systems they engage with, which, in turn, guides their therapeutic potential and applications.</p> <p>This involves an exhaustive scrutiny of how bioconjugates interact with precise biological targets to unveil molecular recognition, binding affinities, and therapeutic responses. The aim is to reveal the influence bioconjugates wield upon the biological systems they engage with. Thereby elucidating their therapeutic potential and expansive range of applications.</p> <p></p> <table style="width: 845px; margin-left: auto; margin-right: auto;" border="1" height="338"> <tbody> <tr style="height: 37.6406px; background-color: #0086cd;"> <td style="width: 835px; height: 37.6406px; text-align: center;" colspan="2"><span color="#ffffff" style="color: #ffffff;"><b>Key aspects of pharmacodynamics</b></span></td> </tr> <tr> <td style="width: 264.781px;"><strong><span><span style="color: #ffffff;">•</span> </span>Affinity and Specificity</strong></td> <td style="width: 564.219px;">The strength and specificity of binding interactions with target molecules are paramount. These factors determine the therapeutic efficacy of the bioconjugate.</td> </tr> <tr> <td style="width: 264.781px;"><strong><span style="color: #ffffff;">• </span>Mechanism of Action</strong></td> <td style="width: 564.219px;">A profound understanding of how the bioconjugate exerts its effect is essential. This can include receptor activation, enzyme inhibition, or other intricate mechanisms.</td> </tr> <tr> <td style="width: 264.781px;"><strong><span style="background-color: #ffffff;"><span style="color: #ffffff;">•</span> </span>Dose-Response Relationship</strong></td> <td style="width: 564.219px;">Defining the concentration-response relationship is a pivotal step in establishing dosing regimens for bioconjugates.</td> </tr> <tr> <td style="width: 264.781px;"><strong><span style="background-color: #ffffff;"><span style="color: #ffffff;">•</span> </span>Pharmacological Effects</strong></td> <td style="width: 564.219px;">A thorough assessment of therapeutic effects, safety, and potential side effects is required, involving rigorous examination of various endpoints.</td> </tr> <tr> <td style="width: 264.781px;"><strong><span style="background-color: #ffffff;"><span style="color: #ffffff;">•</span> </span>Duration of Action</strong></td> <td style="width: 564.219px;">The bioconjugate's duration of action influences dosing frequency and therapeutic maintenance.</td> </tr> <tr> <td style="width: 264.781px;"><strong><span style="background-color: #ffffff;"><span style="color: #ffffff;">•</span> </span>Receptor Occupancy</strong></td> <td style="width: 564.219px;">Quantifying the percentage of occupied target receptors is key to characterizing potency.</td> </tr> </tbody> </table> <br /> <h3>Pharmacokinetics (PK)</h3> <p>PK is an intricate scientific discipline focused on unraveling the captivating journey of bioconjugates as they traverse the complex landscape of the human body. This multifaceted journey encompasses a comprehensive examination of the bioconjugates' progression through vital stages, including their absorption, distribution, metabolism, and ultimate elimination. Through this process, the critical intricacies that govern how bioconjugates interact with the human system are uncovered, shaping their therapeutic potential and practical applications.</p> <br /> <table style="width: 810px; margin-left: auto; margin-right: auto;" border="1" height="375"> <tbody> <tr style="height: 37.6406px; background-color: #0086cd;"> <td style="width: 794px; height: 37.6406px; text-align: center;" colspan="2"><span color="#ffffff" style="color: #ffffff;"><b>Key aspects of pharmacokinetics</b></span></td> </tr> <tr> <td style="width: 242.02px;"><strong>  Absorption</strong></td> <td style="width: 551.98px;">Bioavailability, absorption rate constants, and absorption sites influence absorption characteristics. These factors impact bioconjugate effectiveness.</td> </tr> <tr> <td style="width: 242.02px;"><strong>  Distribution</strong></td> <td style="width: 551.98px;">The disposition of bioconjugates within the body depends on variables like plasma protein binding, tissue penetration, and the ability to cross biological barriers.</td> </tr> <tr> <td style="width: 242.02px;"><strong>  Metabolism</strong></td> <td style="width: 551.98px;">Understanding metabolic pathways and kinetics is vital, as bioconjugates can undergo transformations, impacting their activity.</td> </tr> <tr> <td style="width: 242.02px;"><strong>  Elimination</strong></td> <td style="width: 551.98px;">Routes and rates of elimination dictate bioconjugate persistence. This process can occur through renal excretion, hepatic metabolism, or alternative routes.</td> </tr> <tr> <td style="width: 242.02px;"><strong>  Pharmacokinetic Parameters</strong></td> <td style="width: 551.98px;">Parameters such as half-life, clearance, volume of distribution, and AUC provide critical insights into bioconjugate behavior.</td> </tr> <tr> <td style="width: 242.02px;"><strong>  Drug-Drug Interactions</strong></td> <td style="width: 551.98px;">Assessing interactions with other substances is essential for determining the bioconjugate's pharmacokinetics.</td> </tr> <tr> <td style="width: 242.02px;"><strong>  Toxicokinetics</strong></td> <td style="width: 551.98px;">Evaluating the kinetics of any toxic components or metabolites is crucial for ensuring safety.</td> </tr> </tbody> </table> <br /> <p>A profound and comprehensive grasp of the pharmacodynamics and pharmacokinetics of bioconjugates stands indispensable for their development and their therapeutic applications. Controlling and understanding both concepts not only provide crucial insights but also permit guiding the meticulous design of bioconjugates, crafting optimal dosing regimens, and projecting their efficacy and safety in the intricate landscape of clinical practice. This profound understanding forms the bedrock for significant advancements in drug delivery, diagnostics, and therapeutic interventions. Through the intricate alignment of these principles, bioconjugates manifest as powerful agents of innovation, optimizing their potential and fostering groundbreaking solutions in the field of life sciences.</p> <p style="text-align: center;"><a href="/uploads/Brochures/Biologics/BioconjugationBRUSFeb2024-sm.pdf" class="btn btn-primary btn-sm" target="_blank" rel="noopener">Download Bioconjugation Brochure</a></p> </div> </div> </div> </section> </div> </section>  <footer class="" style=""> <div class="container container-footer"> <div class="footer-contact"> <div class="row tel m-8 text-center"> <div class="col-12 col-lg-4"> <h5>Main Sales</h5> <div class="row text-center"> <div class="col-12 col-sm-6"> <h5 class="small">UK</h5> <a href="tel:+44 1635 578444">+44 (0)1635 578444</a> </div> <div class="col-12 col-sm-6"> <h5 class="small">USA</h5> <a href="tel:+1 888-681-2933">+1 (888)-681-2933 (toll-free)</a><br> </div> </div> </div> <div class="col-12 col-lg-4"> <style> .contact-main-btn 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Favourites</strong> </div> <div class="modal-body flex-grow-0 my-auto"> <h6 class="mb-7 text-center">Login to View Your Favourites</h6> <a class="btn btn-block btn-xs btn-outline-secondary" href="https://www.biosynth.com/account"> My Account </a> </div> </div> </div> </div> </div> <div class="modal fixed-right fade" id="modalCountry" tabindex="-1" role="dialog" aria-hidden="true"> <div class="modal-dialog modal-dialog modal-lg" role="document"> <div class="modal-content">  <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <i class="fe fe-x" aria-hidden="true"></i> </button> <div id="modalCountry-mini">  <div class="modal-header line-height-fixed font-size-lg"> <strong class="mx-auto"></span> <i class="fa fa-globe"></i> CHANGE LOCATION </strong> </div> <div class="modal-body flex-grow-0 my-auto"> <h6 class="mb-7 text-center">Please select a region and location for accurate pricing information.</h6>  <div class="row"> <div class="col-sm-6"> <span style="margin-left: 14%;">Region</span> <ul class="modal-regions"> <li class="modal-selected modal-selected-Asia" onclick="changeCountry("Asia")">Asia</li> <li class="modal-selected modal-selected-Europe" onclick="changeCountry("Europe")">Europe</li> <li class="modal-selected modal-selected-Africa" onclick="changeCountry("Africa")">Africa</li> <li class="modal-selected modal-selected-Oceania" onclick="changeCountry("Oceania")">Oceania</li> <li class="modal-selected modal-selected-Americas" onclick="changeCountry("Americas")">Americas</li> </ul> </div> <div class="col-sm-6"> <span style="margin-left: 14%;">Location</span> <ul class="modal-locations modal-placeholder select-region" style="display: none;"> <li class="modal-countries" data-country-id="">Select a Region</li> </ul> <ul class="modal-locations modal-Asia" style="display: none;"> <li class="modal-countries modal-countries-1" data-country-id="1">Afghanistan</li> <li class="modal-countries modal-countries-12" data-country-id="12">Armenia</li> <li class="modal-countries modal-countries-16" data-country-id="16">Azerbaijan</li> <li class="modal-countries modal-countries-18" data-country-id="18">Bahrain</li> <li class="modal-countries modal-countries-19" data-country-id="19">Bangladesh</li> <li class="modal-countries modal-countries-26" data-country-id="26">Bhutan</li> <li class="modal-countries modal-countries-34" data-country-id="34">Brunei Darussalam</li> <li class="modal-countries modal-countries-39" data-country-id="39">Cambodia</li> <li class="modal-countries modal-countries-46" data-country-id="46">China</li> <li class="modal-countries modal-countries-223" data-country-id="223">East Timor</li> <li class="modal-countries modal-countries-83" data-country-id="83">Georgia</li> <li class="modal-countries modal-countries-101" data-country-id="101">Hong Kong</li> <li class="modal-countries modal-countries-104" data-country-id="104">India</li> <li class="modal-countries modal-countries-105" data-country-id="105">Indonesia</li> <li class="modal-countries modal-countries-106" data-country-id="106">Iran</li> <li class="modal-countries modal-countries-107" data-country-id="107">Iraq</li> <li class="modal-countries modal-countries-110" data-country-id="110">Israel</li> <li class="modal-countries modal-countries-113" data-country-id="113">Japan</li> <li class="modal-countries modal-countries-115" data-country-id="115">Jordan</li> <li class="modal-countries modal-countries-116" data-country-id="116">Kazakhstan</li> <li class="modal-countries modal-countries-121" data-country-id="121">Kuwait</li> <li class="modal-countries modal-countries-122" data-country-id="122">Kyrgyzstan</li> <li class="modal-countries modal-countries-123" data-country-id="123">Laos</li> <li class="modal-countries modal-countries-125" data-country-id="125">Lebanon</li> <li class="modal-countries modal-countries-132" data-country-id="132">Macao</li> <li class="modal-countries modal-countries-135" data-country-id="135">Malaysia</li> <li class="modal-countries modal-countries-136" data-country-id="136">Maldives</li> <li class="modal-countries modal-countries-148" data-country-id="148">Mongolia</li> <li class="modal-countries modal-countries-153" data-country-id="153">Myanmar</li> <li class="modal-countries modal-countries-156" data-country-id="156">Nepal</li> <li class="modal-countries modal-countries-119" data-country-id="119">North Korea</li> <li class="modal-countries modal-countries-168" data-country-id="168">Oman</li> <li class="modal-countries modal-countries-169" data-country-id="169">Pakistan</li> <li class="modal-countries modal-countries-171" data-country-id="171">Palestine</li> <li class="modal-countries modal-countries-176" data-country-id="176">Philippines</li> <li class="modal-countries modal-countries-181" data-country-id="181">Qatar</li> <li class="modal-countries modal-countries-196" data-country-id="196">Saudi Arabia</li> <li class="modal-countries modal-countries-202" data-country-id="202">Singapore</li> <li class="modal-countries modal-countries-120" data-country-id="120">South Korea</li> <li class="modal-countries modal-countries-212" data-country-id="212">Sri Lanka</li> <li class="modal-countries modal-countries-218" data-country-id="218">Syria</li> <li class="modal-countries modal-countries-219" data-country-id="219">Taiwan</li> <li class="modal-countries modal-countries-220" data-country-id="220">Tajikistan</li> <li class="modal-countries modal-countries-222" data-country-id="222">Thailand</li> <li class="modal-countries modal-countries-229" data-country-id="229">Turkey</li> <li class="modal-countries modal-countries-230" data-country-id="230">Turkmenistan</li> <li class="modal-countries modal-countries-235" data-country-id="235">United Arab Emirates</li> <li class="modal-countries modal-countries-241" data-country-id="241">Uzbekistan</li> <li class="modal-countries modal-countries-244" data-country-id="244">Vietnam</li> <li class="modal-countries modal-countries-249" data-country-id="249">Yemen</li> </ul> <ul class="modal-locations modal-Europe" style="display: none;"> <li class="modal-countries modal-countries-3" data-country-id="3">Albania</li> <li class="modal-countries modal-countries-6" data-country-id="6">Andorra</li> <li class="modal-countries modal-countries-15" data-country-id="15">Austria</li> <li class="modal-countries modal-countries-21" data-country-id="21">Belarus</li> <li class="modal-countries modal-countries-22" data-country-id="22">Belgium</li> <li class="modal-countries modal-countries-29" data-country-id="29">Bosnia and Herzegovina</li> <li class="modal-countries modal-countries-35" data-country-id="35">Bulgaria</li> <li class="modal-countries modal-countries-56" data-country-id="56">Croatia</li> <li class="modal-countries modal-countries-59" data-country-id="59">Cyprus</li> <li class="modal-countries modal-countries-60" data-country-id="60">Czech Republic</li> <li class="modal-countries modal-countries-61" data-country-id="61">Denmark</li> <li class="modal-countries modal-countries-70" data-country-id="70">Estonia</li> <li class="modal-countries modal-countries-74" data-country-id="74">Faroe Islands</li> <li class="modal-countries modal-countries-76" data-country-id="76">Finland</li> <li class="modal-countries modal-countries-77" data-country-id="77">France</li> <li class="modal-countries modal-countries-84" data-country-id="84">Germany</li> <li class="modal-countries modal-countries-86" data-country-id="86">Gibraltar</li> <li class="modal-countries modal-countries-87" data-country-id="87">Greece</li> <li class="modal-countries modal-countries-93" data-country-id="93">Guernsey</li> <li class="modal-countries modal-countries-102" data-country-id="102">Hungary</li> <li class="modal-countries modal-countries-103" data-country-id="103">Iceland</li> <li class="modal-countries modal-countries-108" data-country-id="108">Ireland</li> <li class="modal-countries modal-countries-109" data-country-id="109">Isle of Man</li> <li class="modal-countries modal-countries-111" data-country-id="111">Italy</li> <li class="modal-countries modal-countries-114" data-country-id="114">Jersey</li> <li class="modal-countries modal-countries-199" data-country-id="199">Kosovo</li> <li class="modal-countries modal-countries-124" data-country-id="124">Latvia</li> <li class="modal-countries modal-countries-129" data-country-id="129">Liechtenstein</li> <li class="modal-countries modal-countries-130" data-country-id="130">Lithuania</li> <li class="modal-countries modal-countries-131" data-country-id="131">Luxembourg</li> <li class="modal-countries modal-countries-165" data-country-id="165">Macedonia</li> <li class="modal-countries modal-countries-138" data-country-id="138">Malta</li> <li class="modal-countries modal-countries-146" data-country-id="146">Moldova</li> <li class="modal-countries modal-countries-147" data-country-id="147">Monaco</li> <li class="modal-countries modal-countries-149" data-country-id="149">Montenegro</li> <li class="modal-countries modal-countries-157" data-country-id="157">Netherlands</li> <li class="modal-countries modal-countries-237" data-country-id="237">Northern Ireland</li> <li class="modal-countries modal-countries-167" data-country-id="167">Norway</li> <li class="modal-countries modal-countries-178" data-country-id="178">Poland</li> <li class="modal-countries modal-countries-179" data-country-id="179">Portugal</li> <li class="modal-countries modal-countries-183" data-country-id="183">Romania</li> <li class="modal-countries modal-countries-184" data-country-id="184">Russia</li> <li class="modal-countries modal-countries-194" data-country-id="194">San Marino</li> <li class="modal-countries modal-countries-198" data-country-id="198">Serbia</li> <li class="modal-countries modal-countries-204" data-country-id="204">Slovakia</li> <li class="modal-countries modal-countries-205" data-country-id="205">Slovenia</li> <li class="modal-countries modal-countries-211" data-country-id="211">Spain</li> <li class="modal-countries modal-countries-215" data-country-id="215">Svalbard and Jan Mayen</li> <li class="modal-countries modal-countries-216" data-country-id="216">Sweden</li> <li class="modal-countries modal-countries-217" data-country-id="217">Switzerland</li> <li class="modal-countries modal-countries-234" data-country-id="234">Ukraine</li> <li class="modal-countries modal-countries-236" data-country-id="236">United Kingdom</li> <li class="modal-countries modal-countries-99" data-country-id="99">Vatican City</li> <li class="modal-countries modal-countries-2" data-country-id="2">Åland Islands</li> </ul> <ul class="modal-locations modal-Africa" style="display: none;"> <li class="modal-countries modal-countries-4" data-country-id="4">Algeria</li> <li class="modal-countries modal-countries-7" data-country-id="7">Angola</li> <li class="modal-countries modal-countries-24" data-country-id="24">Benin</li> <li class="modal-countries modal-countries-30" data-country-id="30">Botswana</li> <li class="modal-countries modal-countries-33" data-country-id="33">British Indian Ocean Territory</li> <li class="modal-countries modal-countries-36" data-country-id="36">Burkina Faso</li> <li class="modal-countries modal-countries-37" data-country-id="37">Burundi</li> <li class="modal-countries modal-countries-40" data-country-id="40">Cameroon</li> <li class="modal-countries modal-countries-38" data-country-id="38">Cape Verde</li> <li class="modal-countries modal-countries-43" data-country-id="43">Central African Republic</li> <li class="modal-countries modal-countries-44" data-country-id="44">Chad</li> <li class="modal-countries modal-countries-50" data-country-id="50">Comoros</li> <li class="modal-countries modal-countries-51" data-country-id="51">Congo</li> <li class="modal-countries modal-countries-52" data-country-id="52">Congo, Democratic Republic of the</li> <li class="modal-countries modal-countries-55" data-country-id="55">Côte d'Ivoire</li> <li class="modal-countries modal-countries-62" data-country-id="62">Djibouti</li> <li class="modal-countries modal-countries-66" data-country-id="66">Egypt</li> <li class="modal-countries modal-countries-68" data-country-id="68">Equatorial Guinea</li> <li class="modal-countries modal-countries-69" data-country-id="69">Eritrea</li> <li class="modal-countries modal-countries-71" data-country-id="71">Eswatini</li> <li class="modal-countries modal-countries-72" data-country-id="72">Ethiopia</li> <li class="modal-countries modal-countries-80" data-country-id="80">French Southern Territories</li> <li class="modal-countries modal-countries-81" data-country-id="81">Gabon</li> <li class="modal-countries modal-countries-82" data-country-id="82">Gambia</li> <li class="modal-countries modal-countries-85" data-country-id="85">Ghana</li> <li class="modal-countries modal-countries-94" data-country-id="94">Guinea</li> <li class="modal-countries modal-countries-95" data-country-id="95">Guinea-Bissau</li> <li class="modal-countries modal-countries-117" data-country-id="117">Kenya</li> <li class="modal-countries modal-countries-126" data-country-id="126">Lesotho</li> <li class="modal-countries modal-countries-127" data-country-id="127">Liberia</li> <li class="modal-countries modal-countries-128" data-country-id="128">Libya</li> <li class="modal-countries modal-countries-133" data-country-id="133">Madagascar</li> <li class="modal-countries modal-countries-134" data-country-id="134">Malawi</li> <li class="modal-countries modal-countries-137" data-country-id="137">Mali</li> <li class="modal-countries modal-countries-141" data-country-id="141">Mauritania</li> <li class="modal-countries modal-countries-142" data-country-id="142">Mauritius</li> <li class="modal-countries modal-countries-143" data-country-id="143">Mayotte</li> <li class="modal-countries modal-countries-151" data-country-id="151">Morocco</li> <li class="modal-countries modal-countries-152" data-country-id="152">Mozambique</li> <li class="modal-countries modal-countries-154" data-country-id="154">Namibia</li> <li class="modal-countries modal-countries-161" data-country-id="161">Niger</li> <li class="modal-countries modal-countries-162" data-country-id="162">Nigeria</li> <li class="modal-countries modal-countries-182" data-country-id="182">Reunion</li> <li class="modal-countries modal-countries-185" data-country-id="185">Rwanda</li> <li class="modal-countries modal-countries-187" data-country-id="187">Saint Helena, Ascension and Tristan da Cunha</li> <li class="modal-countries modal-countries-195" data-country-id="195">Sao Tome and Principe</li> <li class="modal-countries modal-countries-197" data-country-id="197">Senegal</li> <li class="modal-countries modal-countries-200" data-country-id="200">Seychelles</li> <li class="modal-countries modal-countries-201" data-country-id="201">Sierra Leone</li> <li class="modal-countries modal-countries-207" data-country-id="207">Somalia</li> <li class="modal-countries modal-countries-208" data-country-id="208">South Africa</li> <li class="modal-countries modal-countries-210" data-country-id="210">South Sudan</li> <li class="modal-countries modal-countries-213" data-country-id="213">Sudan</li> <li class="modal-countries modal-countries-221" data-country-id="221">Tanzania</li> <li class="modal-countries modal-countries-224" data-country-id="224">Togo</li> <li class="modal-countries modal-countries-228" data-country-id="228">Tunisia</li> <li class="modal-countries modal-countries-233" data-country-id="233">Uganda</li> <li class="modal-countries modal-countries-248" data-country-id="248">Western Sahara</li> <li class="modal-countries modal-countries-250" data-country-id="250">Zambia</li> <li class="modal-countries modal-countries-251" data-country-id="251">Zimbabwe</li> </ul> <ul class="modal-locations modal-Oceania" style="display: none;"> <li class="modal-countries modal-countries-5" data-country-id="5">American Samoa</li> <li class="modal-countries modal-countries-14" data-country-id="14">Australia</li> <li class="modal-countries modal-countries-47" data-country-id="47">Christmas Island</li> <li class="modal-countries modal-countries-48" data-country-id="48">Cocos (Keeling) Islands</li> <li class="modal-countries modal-countries-53" data-country-id="53">Cook Islands</li> <li class="modal-countries modal-countries-75" data-country-id="75">Fiji</li> <li class="modal-countries modal-countries-79" data-country-id="79">French Polynesia</li> <li class="modal-countries modal-countries-91" data-country-id="91">Guam</li> <li class="modal-countries modal-countries-98" data-country-id="98">Heard Island and McDonald Islands</li> <li class="modal-countries modal-countries-118" data-country-id="118">Kiribati</li> <li class="modal-countries modal-countries-139" data-country-id="139">Marshall Islands</li> <li class="modal-countries modal-countries-145" data-country-id="145">Micronesia</li> <li class="modal-countries modal-countries-155" data-country-id="155">Nauru</li> <li class="modal-countries modal-countries-158" data-country-id="158">New Caledonia</li> <li class="modal-countries modal-countries-159" data-country-id="159">New Zealand</li> <li class="modal-countries modal-countries-163" data-country-id="163">Niue</li> <li class="modal-countries modal-countries-164" data-country-id="164">Norfolk Island</li> <li class="modal-countries modal-countries-166" data-country-id="166">Northern Mariana Islands</li> <li class="modal-countries modal-countries-170" data-country-id="170">Palau</li> <li class="modal-countries modal-countries-173" data-country-id="173">Papua New Guinea</li> <li class="modal-countries modal-countries-177" data-country-id="177">Pitcairn</li> <li class="modal-countries modal-countries-193" data-country-id="193">Samoa</li> <li class="modal-countries modal-countries-206" data-country-id="206">Solomon Islands</li> <li class="modal-countries modal-countries-225" data-country-id="225">Tokelau</li> <li class="modal-countries modal-countries-226" data-country-id="226">Tonga</li> <li class="modal-countries modal-countries-232" data-country-id="232">Tuvalu</li> <li class="modal-countries modal-countries-239" data-country-id="239">United States Minor Outlying Islands</li> <li class="modal-countries modal-countries-242" data-country-id="242">Vanuatu</li> <li class="modal-countries modal-countries-247" data-country-id="247">Wallis and Futuna</li> </ul> <ul class="modal-locations modal-Americas" style="display: none;"> <li class="modal-countries modal-countries-8" data-country-id="8">Anguilla</li> <li class="modal-countries modal-countries-10" data-country-id="10">Antigua and Barbuda</li> <li class="modal-countries modal-countries-11" data-country-id="11">Argentina</li> <li class="modal-countries modal-countries-13" data-country-id="13">Aruba</li> <li class="modal-countries modal-countries-17" data-country-id="17">Bahamas</li> <li class="modal-countries modal-countries-20" data-country-id="20">Barbados</li> <li class="modal-countries modal-countries-23" data-country-id="23">Belize</li> <li class="modal-countries modal-countries-25" data-country-id="25">Bermuda</li> <li class="modal-countries modal-countries-27" data-country-id="27">Bolivia</li> <li class="modal-countries modal-countries-28" data-country-id="28">Bonaire, Sint Eustatius and Saba</li> <li class="modal-countries modal-countries-31" data-country-id="31">Bouvet Island</li> <li class="modal-countries modal-countries-32" data-country-id="32">Brazil</li> <li class="modal-countries modal-countries-41" data-country-id="41">Canada</li> <li class="modal-countries modal-countries-42" data-country-id="42">Cayman Islands</li> <li class="modal-countries modal-countries-45" data-country-id="45">Chile</li> <li class="modal-countries modal-countries-49" data-country-id="49">Colombia</li> <li class="modal-countries modal-countries-54" data-country-id="54">Costa Rica</li> <li class="modal-countries modal-countries-57" data-country-id="57">Cuba</li> <li class="modal-countries modal-countries-58" data-country-id="58">Curaçao</li> <li class="modal-countries modal-countries-63" data-country-id="63">Dominica</li> <li class="modal-countries modal-countries-64" data-country-id="64">Dominican Republic</li> <li class="modal-countries modal-countries-65" data-country-id="65">Ecuador</li> <li class="modal-countries modal-countries-67" data-country-id="67">El Salvador</li> <li class="modal-countries modal-countries-73" data-country-id="73">Falkland Islands (Malvinas)</li> <li class="modal-countries modal-countries-78" data-country-id="78">French Guiana</li> <li class="modal-countries modal-countries-88" data-country-id="88">Greenland</li> <li class="modal-countries modal-countries-89" data-country-id="89">Grenada</li> <li class="modal-countries modal-countries-90" data-country-id="90">Guadeloupe</li> <li class="modal-countries modal-countries-92" data-country-id="92">Guatemala</li> <li class="modal-countries modal-countries-96" data-country-id="96">Guyana</li> <li class="modal-countries modal-countries-97" data-country-id="97">Haiti</li> <li class="modal-countries modal-countries-100" data-country-id="100">Honduras</li> <li class="modal-countries modal-countries-112" data-country-id="112">Jamaica</li> <li class="modal-countries modal-countries-140" data-country-id="140">Martinique</li> <li class="modal-countries modal-countries-144" data-country-id="144">Mexico</li> <li class="modal-countries modal-countries-150" data-country-id="150">Montserrat</li> <li class="modal-countries modal-countries-160" data-country-id="160">Nicaragua</li> <li class="modal-countries modal-countries-172" data-country-id="172">Panama</li> <li class="modal-countries modal-countries-174" data-country-id="174">Paraguay</li> <li class="modal-countries modal-countries-175" data-country-id="175">Peru</li> <li class="modal-countries modal-countries-180" data-country-id="180">Puerto Rico</li> <li class="modal-countries modal-countries-186" data-country-id="186">Saint Barthélemy</li> <li class="modal-countries modal-countries-188" data-country-id="188">Saint Kitts and Nevis</li> <li class="modal-countries modal-countries-189" data-country-id="189">Saint Lucia</li> <li class="modal-countries modal-countries-190" data-country-id="190">Saint Martin (French part)</li> <li class="modal-countries modal-countries-191" data-country-id="191">Saint Pierre and Miquelon</li> <li class="modal-countries modal-countries-192" data-country-id="192">Saint Vincent and the Grenadines</li> <li class="modal-countries modal-countries-203" data-country-id="203">Sint Maarten (Dutch part)</li> <li class="modal-countries modal-countries-209" data-country-id="209">South Georgia and the South Sandwich Islands</li> <li class="modal-countries modal-countries-214" data-country-id="214">Suriname</li> <li class="modal-countries modal-countries-227" data-country-id="227">Trinidad and Tobago</li> <li class="modal-countries modal-countries-231" data-country-id="231">Turks and Caicos Islands</li> <li class="modal-countries modal-countries-238" data-country-id="238">United States of America</li> <li class="modal-countries modal-countries-240" data-country-id="240">Uruguay</li> <li class="modal-countries modal-countries-243" data-country-id="243">Venezuela</li> <li class="modal-countries modal-countries-245" data-country-id="245">Virgin Islands (British)</li> <li class="modal-countries modal-countries-246" data-country-id="246">Virgin Islands (U.S.)</li> </ul> </div> </div> </div> <div class="modal-footer line-height-fixed font-size-sm bg-light mt-auto"> <form style="width: 100%;" id="change-country-form" action="https://www.biosynth.com/change/country" method="post"> <input type="hidden" name="_token" value="JnzVqtGxwwRhYzS15iINl8AUaqY02vBT1UidHcxe"> <input type="hidden" name="country" id="modal-selected-id"> <button id="modal-country-submit" class="btn btn-block btn-xs btn-outline-secondary"> Update </button> </form> </div> </div> </div> </div> </div> <a href="javascript:void(0);" id="toTopBtn" class="cd-top" data-abc="true" style="display:none"></a> <input type="hidden" name="hf_base_url" id="hf_base_url" value="https://www.biosynth.com"> <input type="hidden" name="currency_symbol" id="currency_symbol" value=" ">   <script src="https://www.biosynth.com/biocarbo/assets/libs/jquery/dist/jquery.min.js"></script> <script defer src="https://www.biosynth.com/biocarbo/assets/libs/@fancyapps/fancybox/dist/jquery.fancybox.min.js"></script> <script src="https://www.biosynth.com/biocarbo/assets/libs/bootstrap/dist/js/bootstrap.bundle.min.js"></script> <script defer src="https://www.biosynth.com/biocarbo/assets/libs/flickity/dist/flickity.pkgd.min.js"></script> <script defer src="https://www.biosynth.com/biocarbo/assets/libs/jarallax/dist/jarallax.min.js"></script> <script defer src="https://www.biosynth.com/biocarbo/assets/libs/smooth-scroll/dist/smooth-scroll.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-3-typeahead/4.0.1/bootstrap3-typeahead.min.js"></script> <script defer src="//cdn.jsdelivr.net/npm/sweetalert2@11"></script>  <script defer src="https://www.biosynth.com/biocarbo/assets/js/scripts.min.js?v=1.15"></script> <script defer src="https://www.biosynth.com/biocarbo/assets/js/cart.min.js?v=2.23"></script> <script> /** GTM Vars **/ var gtm_currency = "USD"; var gtm_page_type = "Web Page"; var gtm_category = ""; var gtm_category_2 = ""; var gtm_category_3 = ""; (function(ss,ex){window.ldfdr=window.ldfdr||function(){(ldfdr._q=ldfdr._q||[]).push([].slice.call(arguments));};(function(d,s){fs=d.getElementsByTagName(s)[0];function ce(src){var cs=d.createElement(s); cs.src=src;cs.async=1;fs.parentNode.insertBefore(cs,fs);};ce('https://sc.lfeeder.com/lftracker_v1_'+ss+(ex?'_'+ex:'')+'.js');})(document,'script');})('lAxoEaK9zJD7OYGd'); </script> <div class="modal fade" id="modal-gated" tabindex="-1" role="dialog" aria-hidden="true" style="z-index:1041;"> <div class="modal-dialog modal-dialog-centered modal-lg" role="document"> <div class="modal-content">  <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <i class="fe fe-x" aria-hidden="true"></i> </button>  <div class="modal-header line-height-fixed font-size-lg"> <strong class="mx-auto" id="modal-generic-label">Download</strong> </div>  <div class="modal-body border-bottom" style="padding:1rem;"> <div id="gated-body"> <div class="form-group"> To download this file please provide your email address <br> </div> <div class="form-group"> <div class=""> <input maxlength="100" class="form-control form-control-xs" id="gated-email" type="text" name="email" placeholder="Enter an email" value=""> <span id="email-error" class="invalid-feedback" style="display: none;">Please enter a valid email address</span> </div> </div> <div class="form-group"> <div class=""> <div id="recaptcha-element"></div> </div> <span id="recapcha-error" class="invalid-feedback" style="display: none;">Recaptcha (I'm not a robot)</span> </div> <div class="form-group"> <button type="button" class="btn btn-primary btn-block" id="gated-form-submit" value="">Download</button> </div> </div> <div id="gated-thanks" style="display: none;">Thank you, you will receive an email shortly with a link to the file.</div> <div id="gated-not-found" style="display: none;">We're sorry, this content is not available.</div> </div> </div> </div> </div> <script type="text/javascript"> var route2 = "https://www.biosynth.com/search?searchtype=typeahead"; // const ResentSearches = JSON.parse(null); // console.log(searches); $('#search').typeahead({ autoSelect: true, minLength: 2, source: function(query, process) { $('.recent-searches').hide(); query = normaliseSearchQuery(query); return $.get(route2, { query: query }, function(result) { var buffer = ""; if (result.data.length) { displayText = ""; if (result.data[0].entryType == "CAS") { displayText = "CAS No: "; } else if (result.data[0].entryType == "CATNo") { displayText = "CAT No: "; } for (var i = 0; i < result.data.length; i++) { var item = result.data[i]; if(item.direct_url == ""){ buffer += "<li><a href='/p/" + encodeURI(item.suggestion).replace(/'/g, "%27") + "?type=" + item.entryType + "'>" + displayText + item .suggestion.toUpperCase() + "</a></li>"; }else{ newWin = ""; if(item.new_win){ newWin = "target='_blank'"; } buffer += "<li class=\"custom\"><a href='" + item.direct_url + "' "+newWin+">" +item.suggestion + "</a></li>"; } } $('#search-results-list').html(buffer); } if (result.data.length > 0) { $('.search-results').show(); } else { $('.search-results').hide(); } }); } }); // $(document).keyup(function(e){ // if($('#search').is(':focus')) { // $('.recent-searches').show(); // return ; // } // else { // $('.recent-searches').hide(); // } // var key = e.which; // }); $('#search').focus(function() { $('.recent-searches').show(); }); // $('#search').blur(function(event) { // console.log(event.target); // $('.recent-searches').hide(); // }); /** TODO This needs sorting - the typeahead does not work like the old one **/ $(document).click(function(event) { if ((event.target != 'search-list a' || event.targe != 'recent-searches a') && !$('#search').is(':focus') ) { $('.recent-searches').hide(); $('.search-results, .search-results2').hide(); } }); /* $('#search').blur(function() { //if( !$(this).val() ) { $('.search-results').hide(); //} }); */ $(document).mouseup(function(e) { var container = $("#cofa_search_popover"); // if the target of the click isn't the container nor a descendant of the container if (!container.is(e.target) && container.has(e.target).length === 0) { container.hide(); } }); $('#document-search').click(function() { $("#cofa_search_popover").toggle(); }); function docSearch(type) { var search = $.trim($('#' + type + '_search').val()); $('.' + type + '_validation').hide(); $('.' + type + '_results').hide(); if (search.length && search != '') { swal.showLoading(); $.ajax({ url: "/document/search/" + type, type: "POST", data: { "search": search, "_token": "JnzVqtGxwwRhYzS15iINl8AUaqY02vBT1UidHcxe" }, dataType: "json", }).then(function(data, status, xhr) { swal.close() if (data.length && type != 'msds') { $('.' + type + '_results').html(data[0]); $('.' + type + '_results').show(); // console.log(data[0]); } else if (data.length && type == 'msds') { $('.' + type + '_results').html(data); $('.' + type + '_results').show(); } else { $('.' + type + '_validation').show(); } }) } else { $('.' + type + '_validation').show(); } } function docSearchAccordian(type) { var search = $.trim($('#' + type + '_search_2').val()); $('.' + type + '_validation_2').hide(); $('.' + type + '_results_2').hide(); if (search.length && search != '') { $.ajax({ url: "/document/search/" + type, type: "POST", data: { "search": search, "_token": "JnzVqtGxwwRhYzS15iINl8AUaqY02vBT1UidHcxe" }, dataType: "json", }).then(function(data, status, xhr) { if (data.length) { $('.' + type + '_results_2').html(data[0]); $('.' + type + '_results_2').show(); // console.log(data[0]); } else { $('.' + type + '_validation_2').show(); } // console.log(data); // console.log(type); }) } else { $('.' + type + '_results_2').hide(); $('.' + type + '_validation_2').show(); } } </script> <script> function changeCountry(region) { // $('.modal-countries').hide(); $('.modal-locations').hide(); $('.modal-'+region).show(); $('.modal-countries').removeClass('modal-location-selected'); $('.modal-selected').removeClass('modal-country-selected'); $('.modal-selected').removeClass('modal-location-selected'); $('.modal-selected-'+region).addClass('modal-location-selected'); } $(document).ready(function() { var currentRegion = "" // var currentCountry = "" $('.modal-'+currentRegion).show(); $('.modal-selected-'+currentRegion).addClass('modal-location-selected'); // $('.modal-countries-'+currentCountry).addClass('modal-location-selected'); $('.modal-locations').find("[data-country-id='']").addClass('modal-location-selected'); $('.modal-countries').click(function() { $('.modal-countries').removeClass('modal-country-selected'); $('.modal-countries').removeClass('modal-location-selected'); $(this).addClass('modal-country-selected'); }); $('#modal-country-submit').click(function(e) { e.preventDefault(); var selectedCountry = $('.modal-country-selected').attr("data-country-id"); if(selectedCountry) { var form = $('#change-country-form'); $('#modal-selected-id').val(selectedCountry); form[0].submit(function(){return false}); } //console.log(selectedCountry); }); $(".modal-countries").dblclick(function(){ $("#modal-country-submit").click(); }); $(".modal-placeholder").show(); $('#modalCountry').modal('show'); if(currentRegion !== ""){ $(".select-region").hide(); } }); </script> <script type="text/javascript"> function requestMSDSLoader(){ location.href = "/p/"+$("#msds_search").val()+"?requestMSDS=1"; } </script> <script> $(document).ready(function() { var gatedlink = null; $(".gated-content-link").click(function(e) { e.stopPropagation(); e.preventDefault(); var myClass = $(this).attr("class"); gatedlink = $(this).attr("href"); $('#gated-thanks').hide(); $('#gated-not-found').hide(); $("#recapcha-error").hide(); $("#email-error").hide(); $('#gated-body').show(); $('#modal-gated').modal('show'); setTimeout(function() { createRecaptcha(); }, 100); }); function createRecaptcha() { try { grecaptcha.render("recaptcha-element", { sitekey: "6LcQFtohAAAAAMghy0P4_kNWN1QZmc6F0E4YSfkM", theme: "light" }); } catch (error) { /*possible duplicated instances*/ grecaptcha.reset(); // grecaptcha.reset("recaptcha-element", { sitekey: "6LcQFtohAAAAAMghy0P4_kNWN1QZmc6F0E4YSfkM" }); } } $("#modal-gated").on("hidden.bs.modal", function() { // grecaptcha.reset("recaptcha-element"); }); $("#gated-form-submit").click(function(e) { e.stopPropagation(); e.preventDefault(); $("#email-error").hide(); $("#recapcha-error").hide(); $('#gated-not-found').hide(); // var link = $(".gated-content-link").attr("href"); var link = gatedlink; link = link.replace('/gated/', '') var gatedEmail = $('#gated-email').val(); var grecaptcharesponse = $('#g-recaptcha-response').val(); if (!gatedEmail) { $("#email-error").show(); } if (!grecaptcharesponse) { $("#recapcha-error").show(); } if (!grecaptcharesponse || !gatedEmail) { return; } Swal.showLoading(); $.ajax({ url: "/protected/link/" + link, type: 'post', data: { email: gatedEmail, grecaptcharesponse: grecaptcharesponse, _token: "JnzVqtGxwwRhYzS15iINl8AUaqY02vBT1UidHcxe" }, success: function(data) { Swal.close(); if(data.not_found) { $('#gated-not-found').show(); } else { $('#gated-thanks').show(); } $('#gated-body').hide(); }, error: function(data) { Swal.close(); if (data.responseJSON['errors'].hasOwnProperty('email')) { $("#email-error").show(); } if (data.responseJSON['errors'].hasOwnProperty('grecaptcharesponse')) { $("#recapcha-error").show(); } } }); }); }); </script>  <script src="https://cdn.jsdelivr.net/npm/tooltipster@4.2.8/dist/js/tooltipster.bundle.min.js"></script>  <script defer> // $(document).ready(function() { window.__lc = window.__lc || {}; window.__lc.license = 17516559; ;(function(n,t,c){function i(n){return e._h?e._h.apply(null,n):e._q.push(n)}var e={_q:[],_h:null,_v:"2.0",on:function(){i(["on",c.call(arguments)])},once:function(){i(["once",c.call(arguments)])},off:function(){i(["off",c.call(arguments)])},get:function(){if(!e._h)throw new Error("[LiveChatWidget] You can't use getters before load.");return i(["get",c.call(arguments)])},call:function(){i(["call",c.call(arguments)])},init:function(){var 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