CINXE.COM

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<div class="paragraph paragraph--type--language-links paragraph-id--1165 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taiwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">Traditional Chinese</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1166 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">United Kingdom </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="673" role="article" about="/alnylam-uk" class="clp full clearfix"> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--banner-with-text paragraph-id--1238 paragraph--view-mode--default"> <div class="paragraph paragraph--type--banner-with-text paragraph-id--1238 paragraph--view-mode--default"> <div id="simple-banner-with-text-wrapper" style="background: url(/sites/default/files/2024-08/alvin-image.png); background-size: cover; background-repeat: no-repeat;"> <div class="text-wrapper" style="width:1130px;margin:auto;"> <div class="upper-text"> <h2>The RNAi Revolution is</h2> <h1>DISRUPTING DISEASE<span class="tm-symbol">™</span></h1> </div> </div> </div> <div class="mobile-upper-text"> <h2>The RNAi Revolution is</h2> <h1>DISRUPTING DISEASE<span class="tm-symbol">™</span></h1> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-banner-overlay paragraph-id--1240 paragraph--view-mode--default"> <div id="clp-banner-overlay"> <div class="banner-text-wrapper" style="width:1130px; margin:auto;"> <div class="text-box"> <style type="text/css">@media only screen and (max-width: 1000px) { .mob-tab-mb-30 { margin-bottom: 30px !important; } } </style> <section> <h1 class="text-align-center"><strong>ALNYLAM IS LEADING THE RNAi <span style="white-space:nowrap;">REVOLUTION<span class="tm-symbol">™</span></span></strong></h1> <p class="text-align-center mb-0">Alnylam is pioneering RNA interference (RNAi) therapeutics which silence genes that cause or contribute to disease by</p> <p class="text-align-center mob-tab-mb-30">disrupting the production of specific proteins. We believe that this technology has the potential to have a transformative impact on human health.</p> </section> </div> </div> <div class=" popup-content" style="display:none; background:#fff;"> <div class="field field--name-field-pop-up-field field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-html-background paragraph-id--1242 paragraph--view-mode--default"> <div id="clp-html-content-background" style="background-color:#f9f9fa;"> <div class="content-wrapper" style="width:1130px; margin:auto; "> <div class="clp-html-background-desc"> <h2 class="text-align-center"><strong>RNAi: A REVOLUTION IN BIOLOGY BUILT ON NOBEL PRIZE-WINNING RESEARCH</strong></h2> <p class="text-align-center">RNA interference (RNAi) is a breakthrough in understanding how genes are regulated in cells. It also represents a completely new approach to drug discovery and development. The 2006 Nobel Prize for Physiology or Medicine, awarded to Craig Mello and Andrew Fire, recognised the importance of RNAi as a major scientific discovery.</p> </div> <div class=" popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-html-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> <div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-html-background paragraph-id--1244 paragraph--view-mode--default"> <div id="clp-html-content-background" style="background-color:;"> <div class="content-wrapper" style="width:px; margin:auto; "> <div class="clp-html-background-desc"> <section class="whole-full-with-video-area" style="background: url(/sites/default/files/2022-01/cta_rnai_11.jpg) no-repeat top left;height: 550px; background-size: cover; background-attachment: fixed;"> <div class="full-width-video-content"><a class="cboxElement" data-colorbox-inline=".full-width-video-box" style="width: 650px; height:400px;"> </a> <div class="full-width-video-title"> <h2><a class="cboxElement" data-colorbox-inline=".full-width-video-box" style="width: 650px; height:400px;">DISCOVER HOW RNAi WORKS</a></h2> <a class="cboxElement" data-colorbox-inline=".full-width-video-box" style="width: 650px; height:400px;"><img loading="eager" src="/themes/custom/alnylam/images/button-desktop-play-button-40-px.png" /> </a></div> <a class="cboxElement" data-colorbox-inline=".full-width-video-box" style="width: 650px; height:400px;"> </a> <div class="full-width-video-box" style="display: none;"> <div class="field field--name-field-embed-video field--type-video-embed-field field--label-hidden field--item"> <div class="video-embed-field-provider-youtube video-embed-field-responsive-video form-group"> <div style="padding:56.25% 0 0 0;position:relative;"><a class="cboxElement" data-colorbox-inline=".full-width-video-box" style="width: 650px; height:400px;"><iframe allow="autoplay; fullscreen; picture-in-picture; clipboard-write" src="https://player.vimeo.com/video/994868818?badge=0&autopause=0&player_id=0&app_id=58479" style="position:absolute;top:0;left:0;width:100%;height:100%;" title="RNAi Therapeutics - How this New Class of Medicines Works"></iframe></a></div> </div> </div> </div> <a class="cboxElement" data-colorbox-inline=".full-width-video-box" style="width: 650px; height:400px;"> </a></div> </section> </div> <div class=" popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-html-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> <div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-left-img-text paragraph-id--1246 paragraph--view-mode--default"> <div id="clp-left-img-text"> <div class="img-text-wrapper" style="width:1130px; margin:auto;"> <div class="img-box"> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item"> <img src="/sites/default/files/2024-11/join-our-team-0.gif" width="696" height="405" alt="join-our-team" loading="lazy" typeof="foaf:Image" class="img-responsive" /> </div> </div> <div class="text-box"> <h2><strong>JOIN OUR TEAM</strong></h2> <p>As we pursue our goal of becoming a commercial organisation that can independently deliver medicines to patients, we are seeking individuals with diverse skills, experiences, and backgrounds to help us build a world-class team. We are based in Cambridge, USA, with offices in Zug, Switzerland, and Maidenhead, UK, but we are also hiring throughout Europe.</p> <p><a data-colorbox-inline=".cta-left-img-text-uk">View current job openings ›</a></p> </div> </div> <div class="cta-left-img-text-uk popup-content" style="display:none; background:#fff;"> <div class="field field--name-field-clp-left-img-text-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> <h2 class="text-center">YOU ARE NOW BEING REDIRECTED</h2> <p class="text-align-center">You are leaving alnylam.uk and are going to our global careers website (https://jobs.alnylam.com/careers), which is in English.</p> <p class="text-center"> <a class="button-more" href="http://jobs.alnylam.com/" target= "_blank">CONTINUE</a> </p> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-html-background paragraph-id--1257 paragraph--view-mode--default"> <div id="clp-html-content-background" style="background-color:#f8f8f8;"> <div class="content-wrapper" style="width:1130px; margin:auto; "> <div class="clp-html-background-desc"> <h1 class="text-align-center"><strong>CONTACT US</strong></h1> <div class="row"> <div class="col-sm-6"> <h2 class="mt-0">Alnylam UK Ltd.</h2> <p>Braywick Gate, Braywick Road, Maidenhead, Berkshire SL6 1DA</p> <p><a href="mailto:info@alnylam.co.uk">info@alnylam.co.uk</a><br /> <a href="tel:+44 (0) 1255 444 400">+44 (0) 1255 444 400</a></p> </div> <div class="col-sm-6"> <p>For medical information, clinical trial questions or to report an adverse event or product complaint:</p> <p>Toll: <a href="tel:+44 1628878592">+44 1628878592</a><br /> Toll-free: <a href="tel:08001412569">08001412569</a> (also hidden caller ID)</p> <p><a href="mailto:medinfo@alnylam.com">medinfo@alnylam.com</a></p> </div> </div> </div> <div class=" popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-html-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> <div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-html-background paragraph-id--1264 paragraph--view-mode--default"> <div id="clp-html-content-background" style="background-color:#ffffff;"> <div class="content-wrapper" style="width:1130px; margin:auto; "> <div class="clp-html-background-desc"> <div class="uk-articles"> <h3>Patient Organization Support</h3> <p>View lists of the past UK patient organizations that Alnylam supported in:</p> <ul> <li><a href="https://www.alnylam.com/wp-content/uploads/2019/06/Alnylam-UK-2018-Patient-Organization-Disclosures.pdf" tabindex="-1" target="_blank">2018</a></li> <li><a href="https://www.alnylam.com/wp-content/uploads/pdfs/20200618-UK-POS.pdf" tabindex="-1" target="_blank">2019</a></li> <li><a href="https://www.alnylam.com/wp-content/uploads/pdfs/PAG-Payments-in-2020-for-Disclosure.pdf" tabindex="-1" target="_blank">2020</a></li> <li><a href="/sites/default/files/pdfs/UK%20PAG%20DATA%202021.pdf" tabindex="-1" target="_blank">2021</a></li> <li><a href="/sites/default/files/pdfs/UK-PAG-DATA-2022.pdf" tabindex="-1" target="_blank">2022</a></li> <li><a href="/sites/default/files/pdfs/uk-pag-data-2023.pdf" tabindex="-1" target="_blank">2023</a></li> </ul> <h3>Joint Working Agreements</h3> <p>View the Executive Summaries for Joint Working Agreements with Alnylam UK below:</p> <p class="mb-0"><strong>Live Joint Workings</strong></p> <ul> <li><a href="/sites/default/files/pdfs/executive-summary-for-nac-genetic-counselling-genetic-testing-support-agreement.pdf" tabindex="-1" target="_blank">National Amyloidosis Centre - hATTR amyloidosis Genetic Counselling and Testing</a></li> <li><a href="/sites/default/files/pdfs/joint-working-executive-summary-nhnn-nov-2024.pdf" tabindex="-1" target="_blank">National Hospital for Neurology and Neurosurgery and National Amyloidosis Centre</a></li> </ul> <p class="mb-0"><strong>Completed Joint Workings</strong></p> <ul> <li><a href="/sites/default/files/pdfs/national-amyloidosis-centre-nac-joint-working-executive-summary-therapeutic-review.pdf" tabindex="-1" target="_blank">National Amyloidosis Centre - hATTR amyloidosis Therapeutic Review - Executive Summary</a></li> <li><a href="/sites/default/files/pdfs/alnylam-hattr-amyloidosis-therapeutic-review-outcomes-summary-august-2024.pdf" tabindex="-1" target="_blank">National Amyloidosis Centre - hATTR amyloidosis Therapeutic Review - Joint Working Outcomes Summary</a></li> <li><a href="/sites/default/files/pdfs/alnylam-executive-summary-for-the-joint-working-agreement.pdf" tabindex="-1" target="_blank">University Hospital Birmingham- Executive Summary</a></li> <li><a href="/sites/default/files/pdfs/outcome-summary-joint-working-project-with-birmingham.pdf" tabindex="-1" target="_blank">University Hospital Birmingham- Joint Working Outcomes Summary</a></li> </ul> <h3>UK Disclosure Reports</h3> <p>UK Disclosure Reports are available on the <a class="js-inter-modal-ul" href="https://search.disclosureuk.org.uk/" target="_blank">ABPI Disclosure UK website</a>.<br /> The UK Transparency Reporting Methodological Note can be viewed <a href="/sites/default/files/pdfs/uk-alnylam-methodNote-2023cy.pdf" target="_blank">here</a>.</p> <h3>Product Information</h3> <p class="mb-0">For information on Alnylam products, please see:</p> <ul> <li><a class="js-inter-modal-ul" href="https://www.medicines.org.uk/emc/company/3990" target="_blank">Great Britain Product Information</a></li> <li><a class="js-inter-modal-ul" href="https://www.emcmedicines.com/en-gb/northernireland/company?id=3990" target="_blank">Northern Ireland Product Information</a></li> </ul> <h3>Reporting of Side Effects</h3> <p><strong>Reporting of side effects:</strong> If you have any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the <a class="js-inter-modal-ul" href="https://yellowcard.mhra.gov.uk/" target="_blank">Yellow Card Scheme</a>. By reporting side effects, you can help provide more information on the safety of this medicine.</p> <p><strong>Alnylam UK Ltd.</strong></p> <p>Date of prep: November 2024<br /> CORP-UK-00048</p> </div> </div> <div class=" popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-html-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> <div> </div> </div> </div> </div> </article> <section id="block-interstitialmodal" class="block block-block-content block-block-content91077066-95c8-4915-8931-1413e257836b clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"> <div class="modal" id="inter-modal" role="dialog" tabindex="-1"> <div class="inner" role="document"> <button aria-label="Close" class="close" data-dismiss="modal" type="button"></button> <div class="content"> <div class="title">You are now leaving Alnylam.com</div> <p>The following content may not be associated with Alnylam Pharmaceuticals.</p> <p>Links to all outside sites are provided as a reference for our visitors.</p> <p>Alnylam Pharmaceuticals does not endorse and is not responsible for the content on sites that are not owned and operated by Alnylam Pharmaceuticals.</p> <a class="confirm button-more" href="">Proceed to Site</a> </div> </div></div></div> </section> <section id="block-interstitialmodaluk" class="block block-block-content block-block-contentd6dd310a-faff-46b0-b579-c1f82210c8a4 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"> <div class="modal" id="inter-modal-uk" role="dialog" tabindex="-1"> <div class="inner" role="document"><button aria-label="Close" class="close" data-dismiss="modal" type="button"></button> <div class="content"> <div class="title">You are now leaving Alnylam.uk</div> <p>You are being re-directed to an external website unconnected to Alnylam UK Ltd and the Alnylam group. 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