Risk for new-onset diabetes mellitus after transplantation:

<!DOCTYPE html> <html lang="hi"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Risk for new-onset diabetes mellitus after transplantation: | 11148</title> <meta name="keywords" content="Moro O Salifu, Dale Distant, Dhiren M Haria, Mariya Stratilatova, Sheni Meghani, Joon Hong, Nabil Sumrani, Eli Friedman and Mariana S Markell, "/> <meta name="description" content="Background: The impact of the type of calcineurin inhibitor on the development of new-onset diabetes after transplantation (NODAT) has been difficult to as..11148"/> <meta name="citation_publisher" content="खुली पहुंच वाली पत्रिकाएँ" /> <meta name="citation_journal_title" content="क्लिनिक के जरिए डॉक्टर की प्रैक्टिस"> <meta name="citation_title" content="Risk for new-onset diabetes mellitus after transplantation: implication of advanced age and immunosuppressive therapy"> <meta name="citation_author" content="Moro O Salifu" /> <meta name="citation_author" content="Dale Distant" /> <meta name="citation_author" content="Dhiren M Haria" /> <meta name="citation_author" content="Mariya Stratilatova" /> <meta name="citation_author" content="Sheni Meghani" /> <meta name="citation_author" content="Joon Hong" /> <meta name="citation_author" content="Nabil Sumrani" /> <meta name="citation_author" content="Eli Friedman" /> <meta name="citation_author" content="Mariana S Markell" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="2"> <meta name="citation_issue" content="4"> <meta name="citation_abstract" content="Background: The impact of the type of calcineurin inhibitor on the development of new-onset diabetes after transplantation (NODAT) has been difficult to assess due to contradictory results in published studies using heterogeneous populations. Aim: We attempted to assess the relative risk for development of NODAT in a population of age-stratified Afro–Caribbean and Hispanic renal-transplant recipients treated with cyclosporin A (CSA) or tacrolimus in an urban academic medical center (n = 284). Patients & methods: Patients, based on age distribution, were divided into group 1 (20–44 years; n = 85); group 2 (45–56 years; n = 110); and group 3 (57–79 years; n = 85). Results: In each age group, tacrolimus-treated patients had significantly higher rates of NODAT (7, 17 and 15%) compared with CSA-treated patients (2, 9 and 7%); p = 0.015. The risk of NODAT was increased in age group 2 (hazard ratio: 4.7; 95% confidence interval: 2.0–11.0; p = 0.01) and group 3 (hazard ratio :3.4; 95% confidence interval: 1.4–8.5; p = 0.01) compared with group 1 and use of tacrolimus compared with CSA (hazard ratio: 2.7; 95% confidence interval: 1.4–5.0; p = 0.01). Race, gender, acute rejection episodes and other demographic factors were insignificant factors between the age groups. Conclusion: We conclude that, in our population, the risk of NODAT increases with age and use of tacrolimus. Discrepancies in assigning risk to immunosuppressive regimens in previous studies may be confounded by the analysis of mixed age groups or predominantly younger patients. 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</div> <div class="col-md-7 sm-margin-b-30"> <h2 class="breadcrumbs-v5-title">क्लिनिक के जरिए डॉक्टर की प्रैक्टिस</h2> </div> </div> </div> </section> <style> .breadcrumbs-v5 { position: relative; z-index: 1; background: url(https://www.openaccessjournals.com/admin/banners/clinical-practice-therapy-banner.jpg) no-repeat; background-size: cover; background-position: 50% 20%; padding: 80px 0 80px; text-align:center; } .breadcrumbs-v5 .breadcrumbs-v5-title { font-size: 60px; } #issn{ line-height:30px; color:#fff; } </style> <div class="bg-color-sky-light">  <div class="content container"> <div class="row"> <div class="col-md-12 md-margin-b-50">  <article class="blog-grid margin-b-30"> <div class="blog-grid-content">  <h3 class="blog-grid-title-lg">अमूर्त</h3> <h1 class="fweight-400 font-size-26"> Risk for new-onset diabetes mellitus after transplantation: implication of advanced age and immunosuppressive therapy </h1> Moro O Salifu, Dale Distant, Dhiren M Haria, Mariya Stratilatova, Sheni Meghani, Joon Hong, Nabil Sumrani, Eli Friedman and Mariana S Markell<br /><br /> <p style=\"\\"text-align:\">Background: The impact of the type of calcineurin inhibitor on the development of new-onset diabetes after transplantation (NODAT) has been difficult to assess due to contradictory results in published studies using heterogeneous populations. Aim: We attempted to assess the relative risk for development of NODAT in a population of age-stratified Afro–Caribbean and Hispanic renal-transplant recipients treated with cyclosporin A (CSA) or tacrolimus in an urban academic medical center (n = 284). Patients & methods: Patients, based on age distribution, were divided into group 1 (20–44 years; n = 85); group 2 (45–56 years; n = 110); and group 3 (57–79 years; n = 85). Results: In each age group, tacrolimus-treated patients had significantly higher rates of NODAT (7, 17 and 15%) compared with CSA-treated patients (2, 9 and 7%); p = 0.015. The risk of NODAT was increased in age group 2 (hazard ratio: 4.7; 95% confidence interval: 2.0–11.0; p = 0.01) and group 3 (hazard ratio :3.4; 95% confidence interval: 1.4–8.5; p = 0.01) compared with group 1 and use of tacrolimus compared with CSA (hazard ratio: 2.7; 95% confidence interval: 1.4–5.0; p = 0.01). Race, gender, acute rejection episodes and other demographic factors were insignificant factors between the age groups. Conclusion: We conclude that, in our population, the risk of NODAT increases with age and use of tacrolimus. Discrepancies in assigning risk to immunosuppressive regimens in previous studies may be confounded by the analysis of mixed age groups or predominantly younger patients.</p> <div class="alert alert-info text-left"><b>:</b> </div> </div> </article> </div> </div> </div> </div>  <footer id="footer" class="cu_footer"> <div class="container"> <div class="row padding-t-20 padding-b-20"> <div class="col-md-10"> <ul> <li ><a href="https://hindi.openaccessjournals.com/">घर</a></li> <li ><a href="https://hindi.openaccessjournals.com/about-us.html">हमारे बारे में</a></li> <li ><a href="https://hindi.openaccessjournals.com/journals.html">पत्रिकाओं</a></li> <li ><a href="https://hindi.openaccessjournals.com/instructionsforauthors.html">लेखक दिशानिर्देश</a></li> <li ><a href="https://hindi.openaccessjournals.com/contact-us.html">संपर्क करें</a></li> </ul>  </div> <div class="col-md-2">  <ul class="list-inline ul-li-lr-2 text-right sm-text-center margin-b-0"> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://www.facebook.com/profile.php?id=100076418779107" target="_blank"> <i class="animate-theme-icons-element fa fa-facebook"></i> </a> </li> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://twitter.com/OpenaccessJ" target="_blank"> <i class="animate-theme-icons-element fa fa-twitter"></i> </a> </li> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://www.linkedin.com/company/open-access-journal" target="_blank"> <i class="animate-theme-icons-element fa fa-linkedin"></i> </a> </li> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://www.instagram.com/openaccess_journals/" target="_blank"> <i class="animate-theme-icons-element fa fa-instagram"></i> </a> </li> </ul>  </div> </div>  <div class="footer-v2-copyright"> <p class="pclas"><a href="https://hindi.openaccessjournals.com/" title="यहाँ क्लिक करें" class="color-white">खुली पहुंच वाली पत्रिकाएँ</a> © 2025</p> </div>  </div> <div class="app-view"> Get the App <p><a href="https://play.google.com/store/apps/details?id=com.journals.openaccessjournals" target="_blank"><i class="fa fa-android" aria-hidden="true"></i></a></p> </div> </footer>    <div class="sidebar-content-overlay"></div>   <a href="javascript:void(0);" class="js-back-to-top back-to-top-theme"></a> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/jquery.migrate.min.js"></script> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/bootstrap/js/bootstrap.min.js"></script>   <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/jquery.back-to-top.js"></script> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/jquery.equal-height.js"></script>   <script async src="https://app.wabi-app.com/widget/js/wabi.js?phone_number=+44-1704-335730&lang=en&position=left"></script> </div> </body> </html>

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Risk for new-onset diabetes mellitus after transplantation: | 11148