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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Xb+wq2sL4jvG0fBTG/eMEP5XO4OyfuftJkHCenWq7Rc2rWqcVBUCN07vbVCLu1Qjx57GoNBwTiIdxFiRD3Preg==" /> <meta name="citation_title" content="In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain" /> <meta name="citation_publication_date" content="2012/01/01" /> <meta name="citation_journal_title" content="Neurobiology of aging" /> <meta name="citation_author" content="Victor Victor" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain" /> <meta name="twitter:title" content="In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain" /> <meta name="twitter:description" content="The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain" /> <meta property="og:title" content="In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects" /> <meta property="article:author" content="https://uv.academia.edu/VictorVictor" /> <meta name="description" content="The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects" /> <title>(PDF) In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain | Victor Victor - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '9387f500ddcbb8d05c67bef28a2fe0334f1aafb8'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1733007434000); window.Aedu.timeDifference = new Date().getTime() - 1733007434000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects of aging on the benzodiazepine (BDZ) recognition site of the GABA(A) receptor. To visualize BDZ site availability, [(11)C]-flumazenil microPET acquisitions were conducted in young and old rats. The data were analyzed and region of interest analyses were applied to validate the voxel-wise approach. We observed decreased [(11)C]-flumazenil binding in the aged rat brains in comparison with the young control group. More specifically, clusters of reduced radioligand uptake were detected in the bilateral hippocampus, cerebellum, midbrain, and bilateral frontal and parieto-occipital cortex. Our results support the pertinence of voxel-wise quantification in the analysis of microPET data. Moreover, these findings indicate that the aging process i...","author":[{"@context":"https://schema.org","@type":"Person","name":"Victor Victor"}],"contributor":[],"dateCreated":"2015-06-23","dateModified":null,"datePublished":"2012-01-01","headline":"In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain","inLanguage":"en","keywords":["Aging","Positron Emission Tomography","Neurobiology","Molecular Imaging","Brain","Animals","Male","Rat Brain","Cortical Development","Clinical Sciences","Rats","Neurobiology of Aging","Protein Binding","Neurosciences","Region of Interest","Control Group"],"locationCreated":null,"publication":"Neurobiology of aging","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"uv"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects of aging on the benzodiazepine (BDZ) recognition site of the GABA(A) receptor. To visualize BDZ site availability, [(11)C]-flumazenil microPET acquisitions were conducted in young and old rats. The data were analyzed and region of interest analyses were applied to validate the voxel-wise approach. We observed decreased [(11)C]-flumazenil binding in the aged rat brains in comparison with the young control group. More specifically, clusters of reduced radioligand uptake were detected in the bilateral hippocampus, cerebellum, midbrain, and bilateral frontal and parieto-occipital cortex. Our results support the pertinence of voxel-wise quantification in the analysis of microPET data. Moreover, these findings indicate that the aging process i...","publication_date":"2012,,","publication_name":"Neurobiology of aging"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [32454711]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":45599407,"attachmentType":"pdf"}"><img alt="First page of “In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/45599407/mini_magick20190211-8386-1wqoubw.png?1549936484" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="32454711" href="https://uv.academia.edu/VictorVictor"><img alt="Profile image of Victor Victor" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Victor Victor</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2012, Neurobiology of aging</p></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The GABA-ergic system, known to regulate neural tissue genesis during cortical development, has been postulated to play a role in cerebral aging processes. Using in vivo molecular imaging and voxel-wise quantification, we aimed to assess the effects of aging on the benzodiazepine (BDZ) recognition site of the GABA(A) receptor. To visualize BDZ site availability, [(11)C]-flumazenil microPET acquisitions were conducted in young and old rats. The data were analyzed and region of interest analyses were applied to validate the voxel-wise approach. We observed decreased [(11)C]-flumazenil binding in the aged rat brains in comparison with the young control group. More specifically, clusters of reduced radioligand uptake were detected in the bilateral hippocampus, cerebellum, midbrain, and bilateral frontal and parieto-occipital cortex. Our results support the pertinence of voxel-wise quantification in the analysis of microPET data. Moreover, these findings indicate that the aging process i...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":45599407,"attachmentType":"pdf","workUrl":"https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":45599407,"attachmentType":"pdf","workUrl":"https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="45599407" data-landing_url="https://www.academia.edu/13197794/In_vivo_molecular_imaging_of_the_GABA_benzodiazepine_receptor_complex_in_the_aged_rat_brain" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="15249184" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15249184/Age_related_changes_in_GABA_and_benzodiazepine_receptor_binding_in_rat_brain_are_influenced_by_sampling_time">Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34319911" href="https://independent.academia.edu/LennardNiles">Lennard Niles</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1988</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time","attachmentId":43401630,"attachmentType":"pdf","work_url":"https://www.academia.edu/15249184/Age_related_changes_in_GABA_and_benzodiazepine_receptor_binding_in_rat_brain_are_influenced_by_sampling_time","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15249184/Age_related_changes_in_GABA_and_benzodiazepine_receptor_binding_in_rat_brain_are_influenced_by_sampling_time"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="61309776" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61309776/Absence_of_modifications_of_the_pharmacological_properties_of_the_GABAA_receptor_complex_during_aging_as_assessed_in_3_and_24_month_old_rat_cerebral_cortex">Absence of modifications of the pharmacological properties of the GABAA receptor complex during aging, as assessed in 3- and 24-month-old rat cerebral cortex</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36332720" href="https://independent.academia.edu/AlbertoMachado1">Alberto Machado</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Pharmacology: Molecular Pharmacology, 1993</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Absence of modifications of the pharmacological properties of the GABAA receptor complex during aging, as assessed in 3- and 24-month-old rat cerebral cortex","attachmentId":74376639,"attachmentType":"pdf","work_url":"https://www.academia.edu/61309776/Absence_of_modifications_of_the_pharmacological_properties_of_the_GABAA_receptor_complex_during_aging_as_assessed_in_3_and_24_month_old_rat_cerebral_cortex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/61309776/Absence_of_modifications_of_the_pharmacological_properties_of_the_GABAA_receptor_complex_during_aging_as_assessed_in_3_and_24_month_old_rat_cerebral_cortex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="125209746" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/125209746/Aging_does_not_alter_the_sensitivity_of_benzodiazepine_receptors_to_GABA_modulation">Aging does not alter the sensitivity of benzodiazepine receptors to GABA modulation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="208874355" href="https://independent.academia.edu/CarmenPintoSepulveda">Carmen Pinto Sepulveda</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurobiology of Aging, 1986</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Aging does not alter the sensitivity of benzodiazepine receptors to GABA modulation","attachmentId":119293545,"attachmentType":"pdf","work_url":"https://www.academia.edu/125209746/Aging_does_not_alter_the_sensitivity_of_benzodiazepine_receptors_to_GABA_modulation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/125209746/Aging_does_not_alter_the_sensitivity_of_benzodiazepine_receptors_to_GABA_modulation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="7996531" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" 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The pentameric receptor is commonly composed of different alpha, beta, and gamma subunits which mediate the function and pharmacology of the receptor and show regional- and temporal-specific expression patterns. Under varying physiological and pathophysiological conditions, this diversity allows a multitude of adaptive changes in subunit composition leading to distinct biological and pharmacological properties of the receptor. Here, we investigated the expression of five major GABA(A) receptors subunits (alpha1, alpha2, alpha3, alpha5, gamma2) in early postnatal, adult, and aged rat brains. Immunohistochemistry was performed at postnatal day 10, 30, 60, 90, 180, 360, and 540. Morphological and semi-quantitative evaluations of regional optical densities revealed specific regional and temporal expression patterns for all subunits. The study clearly demonstrated that changes in GABA(A) receptor distribution not only occur in the early postnatal cortex and hippocampal formation but also during later periods in the adolescent and aging brain. These findings contribute to a better understanding of age-related changes in brain excitability and further elucidate the distinct pharmacological effects of different GABAergic drugs in young and elderly patients.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging","attachmentId":42424656,"attachmentType":"pdf","work_url":"https://www.academia.edu/16627632/Changes_in_neocortical_and_hippocampal_GABAA_receptor_subunit_distribution_during_brain_maturation_and_aging","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/16627632/Changes_in_neocortical_and_hippocampal_GABAA_receptor_subunit_distribution_during_brain_maturation_and_aging"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="25538794" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25538794/Age_related_alterations_in_GABAA_receptor_subunits_in_the_nonhuman_primate_hippocampus">Age-related alterations in GABAA receptor subunits in the nonhuman primate hippocampus</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49105854" href="https://independent.academia.edu/RobertRissman">Robert Rissman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Age-related alterations in GABAA receptor subunits in the nonhuman primate hippocampus","attachmentId":45870661,"attachmentType":"pdf","work_url":"https://www.academia.edu/25538794/Age_related_alterations_in_GABAA_receptor_subunits_in_the_nonhuman_primate_hippocampus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25538794/Age_related_alterations_in_GABAA_receptor_subunits_in_the_nonhuman_primate_hippocampus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="26036542" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26036542/A_comparative_autoradiography_study_in_post_mortem_whole_hemisphere_human_brain_slices_taken_from_Alzheimer_patients_and_age_matched_controls_using_two_radiolabelled_DAA1106_analogues_with_high_affinity_to_the_peripheral_benzodiazepine_receptor_PBR_system">A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49774099" href="https://u-szeged.academia.edu/peterkasa">Peter Kasa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemistry International, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) 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class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="86669407" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/86669407/GABAA_receptor_subtypes_in_the_mouse_brain_Regional_mapping_and_diazepam_receptor_occupancy_by_in_vivo_18_F_flumazenil_PET">GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [(18)F]flumazenil PET</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54837110" href="https://independent.academia.edu/AdrienneHerde">Adrienne Herde</a></div><p class="ds-related-work--metadata ds2-5-body-xs">NeuroImage, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Classical benzodiazepines, which are widely used as sedatives, anxiolytics and anticonvulsants, exert their therapeutic effects through interactions with heteropentameric GABAA receptors composed of two α, two β and one γ2 subunit. Their high affinity binding site is located at the interface between the γ2 and the adjacent α subunit. The α-subunit gene family consists of six members and receptors can be homomeric or mixed with respect to the α-subunits. Previous work has suggested that benzodiazepine binding site ligands with selectivity for individual GABAA receptor subtypes, as defined by the benzodiazepine-binding α subunit, may have fewer side effects and may even be effective in diseases, such as schizophrenia, autism or chronic pain, that do not respond well to classical benzodiazepines. The distributions of the individual α subunits across the CNS have been extensively characterized. However, as GABAA receptors may contain two different α subunits, the distribution of the sub...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"GABAA receptor subtypes in the mouse brain: Regional mapping and diazepam receptor occupancy by in vivo [(18)F]flumazenil PET","attachmentId":91068356,"attachmentType":"pdf","work_url":"https://www.academia.edu/86669407/GABAA_receptor_subtypes_in_the_mouse_brain_Regional_mapping_and_diazepam_receptor_occupancy_by_in_vivo_18_F_flumazenil_PET","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/86669407/GABAA_receptor_subtypes_in_the_mouse_brain_Regional_mapping_and_diazepam_receptor_occupancy_by_in_vivo_18_F_flumazenil_PET"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="5692472" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5692472/GABA_A_receptor_subunit_expression_changes_in_the_rat_cerebellum_and_cerebral_cortex_during_aging">GABA A receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8231077" href="https://independent.academia.edu/ZafarKhan16">Zafar Khan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular Brain Research, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"GABA A receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging","attachmentId":49179266,"attachmentType":"pdf","work_url":"https://www.academia.edu/5692472/GABA_A_receptor_subunit_expression_changes_in_the_rat_cerebellum_and_cerebral_cortex_during_aging","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5692472/GABA_A_receptor_subunit_expression_changes_in_the_rat_cerebellum_and_cerebral_cortex_during_aging"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="15520202" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15520202/Quantitative_Analysis_of_Peripheral_Benzodiazepine_Receptor_in_the_Human_Brain_Using_PET_with_11C_AC_5216">Quantitative Analysis of Peripheral Benzodiazepine Receptor in the Human Brain Using PET with 11C-AC-5216</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34673462" href="https://independent.academia.edu/ChieSeki">Chie Seki</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Nuclear Medicine, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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