{"title":"Pre-Clinical Studying of Antitumor Ramon Preparation: Chronic Toxicity","authors":"Raissa A. Muzychkina, Irina M. Korulkina, Dmitriy Yu. Korulkin","volume":80,"journal":"International Journal of Medical and Health Sciences","pagesStart":491,"pagesEnd":496,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/16230","abstract":"<p>In article the data of chronic toxicity for pre-clinical<br \/>\r\nresearches of Ramon preparation is described. Ramon effects to<br \/>\r\nhormone system and gastrointestinal tract; local irritative effect,<br \/>\r\nallergic, pyrogenic properties and reaction to the immune system<br \/>\r\nwere studied.<\/p>\r\n","references":"<p>[1] R.A.Muzychkina,Natural Anthraquinones. Biological Properties and\r\nPhysicochemical Characteristics, Moscow:Phasis, 1998.\r\n[2] A.A.Adjei, J.K.Buolamwini, Novel Anticancer Drug Protocols, New\r\nYork: Academic Press, 2011\r\n[3] S.K.Gupta, Drug Screening Methods, Kent: Anshan Publishers, 2009.\r\n[4] M.Hidalgo, E.Garrett-Mayer, N.J.Clendeninn, S.G.Ekhardt, Principles\r\nof Anticancer Drug Development, New York: Springer, 2011.\r\n[5] A.A.AlFattah Amara, \u201cMethods other than Experimental Animals for\r\nScreening Antitumor Compounds,\u201d Am. J. Cancer Sci., vol. 2, no. 1, pp.\r\n1-27, 2013.\r\n[6] H.G.Vogel, J.Maas, A.Gebauer, Drug Discovery and Evaluation:\r\nMethods in Clinical Pharmacology, Berlin: Springer, 2011.\r\n[7] J.Kolman, P.Meng, G.Scott,Good clinical practice: standard operating\r\nprocedures for clinical researchers, New-York:J. Wiley & Sons, 1998.<\/p>\r\n","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 80, 2013"}