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data-dom-id="ProfileCheckPaperUpdate-react-component-bb983207-eca8-479c-b60d-d8eddc129e88"></div> <div id="ProfileCheckPaperUpdate-react-component-bb983207-eca8-479c-b60d-d8eddc129e88"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Francesco Chiodo</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://unibo.academia.edu/">Università di Bologna</a>, <a class="u-tcGrayDarker" 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class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Francesco Chiodo</h3></div><div class="js-work-strip profile--work_container" data-work-id="13779423"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779423/Dyslipidaemia_associated_with_antiretroviral_therapy_in_HIV_infected_patients"><img alt="Research paper thumbnail of Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients" class="work-thumbnail" src="https://attachments.academia-assets.com/38125807/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779423/Dyslipidaemia_associated_with_antiretroviral_therapy_in_HIV_infected_patients">Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highly active antiretroviral therapy (HAART) has had a significant impact on the natural history ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highly active antiretroviral therapy (HAART) has had a significant impact on the natural history of human immunodeficiency virus (HIV) infection, leading to a remarkable decrease in its morbidity and mortality, but is frequently associated with clinical and metabolic complications. Fat redistribution or lipodystrophy, hypertriglyceridaemia, hypercholesterolaemia, insulin resistance and diabetes mellitus have been exten- sively reported in subjects treated with protease</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4efb1f39acadad13b4014d14a32b7e40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":38125807,"asset_id":13779423,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/38125807/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779423"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779423]").text(description); $(".js-view-count[data-work-id=13779423]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779423']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779423, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4efb1f39acadad13b4014d14a32b7e40" } } $('.js-work-strip[data-work-id=13779423]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779423,"title":"Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients","translated_title":"","metadata":{"abstract":"Highly active antiretroviral therapy (HAART) has had a significant impact on the natural history of human immunodeficiency virus (HIV) infection, leading to a remarkable decrease in its morbidity and mortality, but is frequently associated with clinical and metabolic complications. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779421"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779421/Paradoxical_immune_reconstitution_inflammatory_syndrome_associated_with_previous_Cryptococcus_neoformans_infection_in_an_HIV_positive_patient_requiring_neurosurgical_intervention"><img alt="Research paper thumbnail of Paradoxical immune reconstitution inflammatory syndrome associated with previous Cryptococcus neoformans infection in an HIV-positive patient requiring neurosurgical intervention" class="work-thumbnail" src="https://attachments.academia-assets.com/44963394/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779421/Paradoxical_immune_reconstitution_inflammatory_syndrome_associated_with_previous_Cryptococcus_neoformans_infection_in_an_HIV_positive_patient_requiring_neurosurgical_intervention">Paradoxical immune reconstitution inflammatory syndrome associated with previous Cryptococcus neoformans infection in an HIV-positive patient requiring neurosurgical intervention</a></div><div class="wp-workCard_item"><span>The new microbiologica</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Immune reconstitution inflammatory syndrome (IRIS) in HIV-1-infected patients is associated with ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Immune reconstitution inflammatory syndrome (IRIS) in HIV-1-infected patients is associated with an exaggerated inflammatory response against an opportunistic infection during highly active antiretroviral therapy. The only review on IRIS associated with Criptococcus neoformans reported 21 episodes including lymphadenitis, necrotizing pneumonitis, breast and cutaneous abscess, and cryptococcomas. To our knowledge this is the first report of IRIS associated with previous meningeal criptococcal infection which required neurosurgical intervention with placement of a ventriculo-peritoneal shunt to drain a CSF cyst formed by exclusion of the temporal horn of the right lateral ventricle. 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Available experiences on the effect of the anti-herpes viruses drug cidofovir provide conflicting results. Herein, we report the clinical, histological, and virological features of a liver transplant recipient successfully treated with a combined therapy of cidofovir and liposomal daunorubicin, associated with a reduction of the immunosuppressive regimen, for an advanced cutaneous and visceral KS.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4031e00b279785e3ca992d736f6d23eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963401,"asset_id":13779420,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963401/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779420"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779420"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779420; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779420]").text(description); $(".js-view-count[data-work-id=13779420]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779420; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779420']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779420, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4031e00b279785e3ca992d736f6d23eb" } } $('.js-work-strip[data-work-id=13779420]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779420,"title":"Human herpesvirus-8-related Kaposi's sarcoma after liver transplantation successfully treated with cidofovir and liposomal daunorubicin","translated_title":"","metadata":{"abstract":"The iatrogenic form of Kaposi\u0026#39;s sarcoma (KS) is typically observed among transplant recipients, and the most appropriate therapeutic approach (usually including reduction of immunosuppression, specific chemotherapy, and/or administration of antiviral agents against human herpes virus-8) is still controversial. 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At present very limited information is available concerning its clinical significance in the setting of HIV infection. A retrospective survey of clinical and microbiological records of 1,374 HIV-infected patients referring to our tertiary care center during a 10-year period (1991-2000) was performed to identify all episodes of S. maltophilia infection and analyze epidemiological, clinical and laboratory variables. The episodes of S. maltophilia bacteremia were compared with those caused by non-typhoid Salmonella spp. occurring in HIV-infected patients referring to our center during the same period, in order to evaluate eventual predisposing risk factors. 61 episodes of S. maltophilia infection were observed in 59 HIV-infected patients: sepsis/bacteremia in 48 cases (78.7%), lower airways infe...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2ad46cd774f2f2aa0bf1633761f80d57" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963384,"asset_id":13779419,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963384/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779419"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779419]").text(description); $(".js-view-count[data-work-id=13779419]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779419']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779419, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2ad46cd774f2f2aa0bf1633761f80d57" } } $('.js-work-strip[data-work-id=13779419]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779419,"title":"Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: a 10-year surveillance study","translated_title":"","metadata":{"abstract":"Stenotrophomonas (Xanthomonas) maltophilia has been increasingly reported as a nosocomial opportunistic pathogen, responsible for serious infectious complications in immunocompromised patients. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779418"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779418/3_Azido_3_deoxythymidine_methotrexate_as_a_novel_antineoplastic_combination_in_the_treatment_of_human_immunodeficiency_virus_related_non_Hodgkins_lymphomas"><img alt="Research paper thumbnail of 3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779418/3_Azido_3_deoxythymidine_methotrexate_as_a_novel_antineoplastic_combination_in_the_treatment_of_human_immunodeficiency_virus_related_non_Hodgkins_lymphomas">3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ERaise">E. Raise</a></span></div><div class="wp-workCard_item"><span>Blood</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously reported that 3&#39;-azido 3&#39;-deoxythymidine (AZT) can possess a significa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously reported that 3&#39;-azido 3&#39;-deoxythymidine (AZT) can possess a significant antineoplastic activity when combined with drugs that disrupt de novo thymidylate synthesis, such as 5-fluorouracil and methotrexate (MTX). The aim of the present study was to evaluate the efficacy and the tolerance of the combination AZT + MTX in human immunodeficiency virus (HIV)-related non-Hodgkin&#39;s lymphoma (NHL). Twenty-nine patients (22 men and 7 women), either newly diagnosed or pretreated, have been enrolled in the trial; the median age was 34 years, 45% had acquired immunodeficiency syndrome before lymphoma and 19 patients had less than 100 CD4 lymphocytes/microL. Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. The treatment plan included three weekly courses of MTX at 1 g/m2 (days 1, 8, and 15) plus oral AZT at 2 g/m2 (days 1, 2, and 3), 4 g/m2 (days 8, 9, and 10), and 6 g/m2 (day...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779418"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779418"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779418; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779418]").text(description); $(".js-view-count[data-work-id=13779418]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779418; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779418']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779418, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13779418]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779418,"title":"3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas","translated_title":"","metadata":{"abstract":"We have previously reported that 3\u0026#39;-azido 3\u0026#39;-deoxythymidine (AZT) can possess a significant antineoplastic activity when combined with drugs that disrupt de novo thymidylate synthesis, such as 5-fluorouracil and methotrexate (MTX). The aim of the present study was to evaluate the efficacy and the tolerance of the combination AZT + MTX in human immunodeficiency virus (HIV)-related non-Hodgkin\u0026#39;s lymphoma (NHL). Twenty-nine patients (22 men and 7 women), either newly diagnosed or pretreated, have been enrolled in the trial; the median age was 34 years, 45% had acquired immunodeficiency syndrome before lymphoma and 19 patients had less than 100 CD4 lymphocytes/microL. Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. The treatment plan included three weekly courses of MTX at 1 g/m2 (days 1, 8, and 15) plus oral AZT at 2 g/m2 (days 1, 2, and 3), 4 g/m2 (days 8, 9, and 10), and 6 g/m2 (day...","publication_name":"Blood"},"translated_abstract":"We have previously reported that 3\u0026#39;-azido 3\u0026#39;-deoxythymidine (AZT) can possess a significant antineoplastic activity when combined with drugs that disrupt de novo thymidylate synthesis, such as 5-fluorouracil and methotrexate (MTX). The aim of the present study was to evaluate the efficacy and the tolerance of the combination AZT + MTX in human immunodeficiency virus (HIV)-related non-Hodgkin\u0026#39;s lymphoma (NHL). Twenty-nine patients (22 men and 7 women), either newly diagnosed or pretreated, have been enrolled in the trial; the median age was 34 years, 45% had acquired immunodeficiency syndrome before lymphoma and 19 patients had less than 100 CD4 lymphocytes/microL. Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. 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Twenty-nine patients (22 men and 7 women), either newly diagnosed or pretreated, have been enrolled in the trial; the median age was 34 years, 45% had acquired immunodeficiency syndrome before lymphoma and 19 patients had less than 100 CD4 lymphocytes/microL. Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779417"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779417/Progressive_multifocal_leucoencephalopathy_in_AIDS_treatment_with_cytosine_arabinoside"><img alt="Research paper thumbnail of Progressive multifocal leucoencephalopathy in AIDS: treatment with cytosine arabinoside" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779417/Progressive_multifocal_leucoencephalopathy_in_AIDS_treatment_with_cytosine_arabinoside">Progressive multifocal leucoencephalopathy in AIDS: treatment with cytosine arabinoside</a></div><div class="wp-workCard_item"><span>AIDS</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779417"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779417"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779417; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779416"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779416/Syndrome_of_recurrent_transient_neurological_deficits_in_patients_with_HIV_infection"><img alt="Research paper thumbnail of Syndrome of recurrent transient neurological deficits in patients with HIV infection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779416/Syndrome_of_recurrent_transient_neurological_deficits_in_patients_with_HIV_infection">Syndrome of recurrent transient neurological deficits in patients with HIV infection</a></div><div class="wp-workCard_item"><span>AIDS Research and Human Retroviruses</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779416"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779416"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779416; 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One hundred forty-nine of 366 (40.7%) and 171/366 (46.7%) samples tested positive by dipstick and serology, respectively. Dipstick sensitivity was calculated to be 84.8% (range between countries, 77.5 to 95%), and specificity was 97.9% (95.9 to 100%).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d6dcc0776542cffa9c39025f15c09b1f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963445,"asset_id":13779415,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963445/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779415"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779415"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779415; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779415]").text(description); $(".js-view-count[data-work-id=13779415]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779415; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779415']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779415, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d6dcc0776542cffa9c39025f15c09b1f" } } $('.js-work-strip[data-work-id=13779415]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779415,"title":"Prevalence of antiretroviral drug resistance in untreated persons newly diagnosed with HIV1 infection","translated_title":"","metadata":{"grobid_abstract":"We evaluated a commercially available immunochromatographic dipstick test to detect Trypanosoma cruzi infection in 366 human serum samples with known serological results from Argentina, Ecuador, Mexico, and Venezuela. 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779414/Streptococcus_bovis_Bacteremia_in_Patients_Infected_with_the_Human_Immunodeficiency_Virus_Case_Reports_and_Literature_Review">Streptococcus bovis Bacteremia in Patients Infected with the Human Immunodeficiency Virus: Case Reports and Literature Review</a></div><div class="wp-workCard_item"><span>European Journal of Clinical Microbiology & Infectious Diseases</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i 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Address correspondence and reprint requests to Leonardo Calza, MD, Department of Clinical and...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Address correspondence and reprint requests to Leonardo Calza, MD, Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna &quot;Alma Mater Studiorum,&quot; S. Orsola Hospital ... 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A randomised, multicentric study" class="work-thumbnail" src="https://attachments.academia-assets.com/44963383/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779410/Clinical_and_immunological_assessment_in_HIV_subjects_receiving_inosine_pranobex_A_randomised_multicentric_study">Clinical and immunological assessment in HIV+ subjects receiving inosine-pranobex. A randomised, multicentric study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ERaise">E. Raise</a></span></div><div class="wp-workCard_item"><span>Medical oncology and tumor pharmacotherapy</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimeth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimethylamino-2-propanol and inosine in a 3:1 molar ratio. In early studies, INPX was found to partially inhibit human immunodeficiency virus (HIV) and to increase the immunocompetence of HIV-infected subjects in vitro. We report the results of a randomised, multicentric clinical trial carried out on 553 HIV+ patients. 261 individuals were treated with INPX (two 500 mg tablets every 6 h for 3 months) and the remaining 292 constituted the untreated control group. INPX treatment was associated with a slightly improved clinical condition or with a trend in that direction, as compared to the untreated group. A preservation of the CD4/CD8 cell ratio values, a decrease in the CD8+ cells and an increase in the Leu 2-7+ cell number better than in the untreated individuals was also observed in the patients taking INPX. No serious or adverse effects of INPX have been observed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="235fc041fe256df9f746f04fe05f8c35" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963383,"asset_id":13779410,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963383/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779410"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779410"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779410; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779410]").text(description); $(".js-view-count[data-work-id=13779410]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779410; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779410']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779410, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "235fc041fe256df9f746f04fe05f8c35" } } $('.js-work-strip[data-work-id=13779410]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779410,"title":"Clinical and immunological assessment in HIV+ subjects receiving inosine-pranobex. 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A randomised, multicentric study"}],"downloadable_attachments":[{"id":44963383,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963383/thumbnails/1.jpg","file_name":"bf02985225.pdf20160421-32534-nc0j60","download_url":"https://www.academia.edu/attachments/44963383/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_and_immunological_assessment_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963383/bf02985225-libre.pdf20160421-32534-nc0j60?1461264999=\u0026response-content-disposition=attachment%3B+filename%3DClinical_and_immunological_assessment_in.pdf\u0026Expires=1734027727\u0026Signature=ad6w2wxcMrQZyh1IqQt~dcGQ2bvR9IsBkCHdqjfpKliZCID6uMX4kDBjw8~dgdpj1~wgWsBDs2dviFvuf7EpqGzoE-P1UjQV1C5gx6qa2QFvicEJLm9FbhwqvKC8j5FHTHwl-7fadaKbc7MDQ9fj4xy0f05C4hOr7TCwt95FxWIqoxv5HkqYvO87IVY~vmrYQrgecjgYfJXGC8z5QmLKQfHYi~Y9NS1OEqBwAcS0jF5YeQ0JC2JpQFooc5dPY3vPOafhpq45pGCJGDl9c1iQYBuUrDIEuOHUSwr0VwgjS27vNdTW~SQCkj8rooWmcKeYZj2OduHtovEskvFZ~sAdew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_and_immunological_assessment_in_HIV_subjects_receiving_inosine_pranobex_A_randomised_multicentric_study","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimethylamino-2-propanol and inosine in a 3:1 molar ratio. In early studies, INPX was found to partially inhibit human immunodeficiency virus (HIV) and to increase the immunocompetence of HIV-infected subjects in vitro. We report the results of a randomised, multicentric clinical trial carried out on 553 HIV+ patients. 261 individuals were treated with INPX (two 500 mg tablets every 6 h for 3 months) and the remaining 292 constituted the untreated control group. INPX treatment was associated with a slightly improved clinical condition or with a trend in that direction, as compared to the untreated group. A preservation of the CD4/CD8 cell ratio values, a decrease in the CD8+ cells and an increase in the Leu 2-7+ cell number better than in the untreated individuals was also observed in the patients taking INPX. No serious or adverse effects of INPX have been observed.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[{"id":44963383,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963383/thumbnails/1.jpg","file_name":"bf02985225.pdf20160421-32534-nc0j60","download_url":"https://www.academia.edu/attachments/44963383/download_file?st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_and_immunological_assessment_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963383/bf02985225-libre.pdf20160421-32534-nc0j60?1461264999=\u0026response-content-disposition=attachment%3B+filename%3DClinical_and_immunological_assessment_in.pdf\u0026Expires=1734027727\u0026Signature=ad6w2wxcMrQZyh1IqQt~dcGQ2bvR9IsBkCHdqjfpKliZCID6uMX4kDBjw8~dgdpj1~wgWsBDs2dviFvuf7EpqGzoE-P1UjQV1C5gx6qa2QFvicEJLm9FbhwqvKC8j5FHTHwl-7fadaKbc7MDQ9fj4xy0f05C4hOr7TCwt95FxWIqoxv5HkqYvO87IVY~vmrYQrgecjgYfJXGC8z5QmLKQfHYi~Y9NS1OEqBwAcS0jF5YeQ0JC2JpQFooc5dPY3vPOafhpq45pGCJGDl9c1iQYBuUrDIEuOHUSwr0VwgjS27vNdTW~SQCkj8rooWmcKeYZj2OduHtovEskvFZ~sAdew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":64900,"name":"Medical Oncology","url":"https://www.academia.edu/Documents/in/Medical_Oncology"},{"id":160242,"name":"Hiv Infection","url":"https://www.academia.edu/Documents/in/Hiv_Infection"},{"id":318308,"name":"Human immunodeficiency virus","url":"https://www.academia.edu/Documents/in/Human_immunodeficiency_virus"},{"id":1622318,"name":"Antiviral Agents","url":"https://www.academia.edu/Documents/in/Antiviral_Agents"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779409"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779409/Preliminary_observations_using_HIV_specific_transfer_factor_in_AIDS"><img alt="Research paper thumbnail of Preliminary observations using HIV-specific transfer factor in AIDS" class="work-thumbnail" src="https://attachments.academia-assets.com/44963379/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779409/Preliminary_observations_using_HIV_specific_transfer_factor_in_AIDS">Preliminary observations using HIV-specific transfer factor in AIDS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ERaise">E. Raise</a></span></div><div class="wp-workCard_item"><span>Biotherapy</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally w...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with 'IF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25 patients the number of Iymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting further investigation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc6ad6753327cc6ed13a070cd3af2e5a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963379,"asset_id":13779409,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963379/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779409"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779409"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779409; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779409]").text(description); $(".js-view-count[data-work-id=13779409]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779409; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779409']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779409, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dc6ad6753327cc6ed13a070cd3af2e5a" } } $('.js-work-strip[data-work-id=13779409]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779409,"title":"Preliminary observations using HIV-specific transfer factor in AIDS","translated_title":"","metadata":{"grobid_abstract":"Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with 'IF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25 patients the number of Iymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting further investigation.","publication_date":{"day":null,"month":null,"year":1996,"errors":{}},"publication_name":"Biotherapy","grobid_abstract_attachment_id":44963379},"translated_abstract":null,"internal_url":"https://www.academia.edu/13779409/Preliminary_observations_using_HIV_specific_transfer_factor_in_AIDS","translated_internal_url":"","created_at":"2015-07-07T22:10:49.063-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588553,"work_id":13779409,"tagging_user_id":32888829,"tagged_user_id":32949890,"co_author_invite_id":688661,"email":"e***e@libero.it","display_order":0,"name":"E. 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All patients were receiving antiviral treatments in association with 'IF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25 patients the number of Iymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting further investigation.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[{"id":44963379,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963379/thumbnails/1.jpg","file_name":"09e4150f1b7a6437df000000.pdf_ev_pub_ext_doc_dl_meta","download_url":"https://www.academia.edu/attachments/44963379/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Preliminary_observations_using_HIV_speci.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963379/09e4150f1b7a6437df000000-libre.pdf_ev_pub_ext_doc_dl_meta?1461264996=\u0026response-content-disposition=attachment%3B+filename%3DPreliminary_observations_using_HIV_speci.pdf\u0026Expires=1734027728\u0026Signature=a0ThN-DmXjnqRlqfsZpsM-lMoXTP57FmyuBVU2hHRI8oawLTttNoWuNNUI8rgbJm87zOv5niQgW59PNeMB8UQRb-lu0mAjo6C5noyi~McbQJVZ1bDP9frf7842Tqgyaj4~KNhnHyxeK2IESFuQjZZgigcUO2eHOmKvezl193IPqXvN8O5YfUCN~KDHLVek5SvIqmRLDawzhiTj9la6hfU47rz1HlNdMHD0wJ7-pQruWV91oZyfp8ExVVClY5eXbwo2F-Tn3c~oJiUo3QowJQtwF3~Rz9Qcakny7iBEv~80gcm7NVIVbMox3BGMBvUx2NYoKB3qU5T9uRdb1hbuoZGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":125564,"name":"Statistical Significance","url":"https://www.academia.edu/Documents/in/Statistical_Significance"},{"id":596568,"name":"Transfer Factor","url":"https://www.academia.edu/Documents/in/Transfer_Factor"},{"id":643875,"name":"Biotherapy","url":"https://www.academia.edu/Documents/in/Biotherapy"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779408/The_need_for_transplantation_of_HIV_positive_subjects_in_Italy"><img alt="Research paper thumbnail of The need for transplantation of HIV-positive subjects in Italy" class="work-thumbnail" src="https://attachments.academia-assets.com/44963412/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779408/The_need_for_transplantation_of_HIV_positive_subjects_in_Italy">The need for transplantation of HIV-positive subjects in Italy</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb82e4891423870ab6316a4b219d554b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963412,"asset_id":13779408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963412/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779408"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779408"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779408; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779408]").text(description); $(".js-view-count[data-work-id=13779408]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779408; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779408']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779408, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The research, involving multiple Italian infectious disease units, emphasizes the pressing necessity to reevaluate the historical exclusion of HIV-positive patients from transplant programs, outlining specific criteria that affect their eligibility. 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The retrieval of a chest radiograph incidentally performed 11 y before and showing a probable primary tuberculosis, paralleled a negligible clinical history. The enlargement of interferon indications needs careful evaluation for prior (usually missed) tuberculosis, to prevent or avoid its possible reactivation. 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Computerized tomography, performed in 10 cases of lymphadenopathy, invariably confirmed the UlS findings. Prevalence [asymptomatic carriers: 8/15 (53%); PGL patients: 8/18 (44%); ARC: 13/27 (48%); AIDS: 12/25 (48%)], number, size, and site of deep nodes were comparable among the different CDC groups. No correlation was found between abdominal and superficial lymphadenopathy. Median serum concentrations of gammaglobulins (g/dl) and IgG (mg/dl) were higher in patients with than without deep nodes (2.25 vs 1.87 and 2540 vs 1900, respectively) (p &amp;lt; 0.01) as well as in cases with than without superficial nodes (2.15 vs 1.80 and 2340 vs 1941, respectively) (p &amp;lt; 0.05). Abdominal lymphadenopathy occurred during all stages of HIV infection even in asymptomatic carriers: this should be considered in the differential diagnosis of UlS-detected deep nodes. 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Enlargement of either deep or superficial nodes seems to reflect a state of polyclonal B cell activation.","internal_url":"https://www.academia.edu/13779406/Abdominal_Lymphadenopathy_Detected_by_Ultrasonography_in_HIV_1_Infection_Prevalence_and_Significance","translated_internal_url":"","created_at":"2015-07-07T22:10:48.813-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588517,"work_id":13779406,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688656,"email":"p***t@med.unibo.it","display_order":0,"name":"Paolo Costigliola","title":"Abdominal Lymphadenopathy Detected by Ultrasonography in HIV-1 Infection: Prevalence and Significance"},{"id":2588546,"work_id":13779406,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":112913,"email":"e***c@ebab.com","display_order":4194304,"name":"Ennio Ricchi","title":"Abdominal Lymphadenopathy Detected by Ultrasonography in HIV-1 Infection: Prevalence and Significance"}],"downloadable_attachments":[],"slug":"Abdominal_Lymphadenopathy_Detected_by_Ultrasonography_in_HIV_1_Infection_Prevalence_and_Significance","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"By using abdominal ultrasonography (UlS), deep nodes were detected in 41 of 85 (48%) HIV-1 positive subjects, most of them heroin addicts, but in none of 85 healthy HIV-negative controls. Computerized tomography, performed in 10 cases of lymphadenopathy, invariably confirmed the UlS findings. Prevalence [asymptomatic carriers: 8/15 (53%); PGL patients: 8/18 (44%); ARC: 13/27 (48%); AIDS: 12/25 (48%)], number, size, and site of deep nodes were comparable among the different CDC groups. No correlation was found between abdominal and superficial lymphadenopathy. Median serum concentrations of gammaglobulins (g/dl) and IgG (mg/dl) were higher in patients with than without deep nodes (2.25 vs 1.87 and 2540 vs 1900, respectively) (p \u0026amp;lt; 0.01) as well as in cases with than without superficial nodes (2.15 vs 1.80 and 2340 vs 1941, respectively) (p \u0026amp;lt; 0.05). Abdominal lymphadenopathy occurred during all stages of HIV infection even in asymptomatic carriers: this should be considered in the differential diagnosis of UlS-detected deep nodes. Enlargement of either deep or superficial nodes seems to reflect a state of polyclonal B cell activation.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[],"research_interests":[{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV"},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy"},{"id":90702,"name":"Ultrasonography","url":"https://www.academia.edu/Documents/in/Ultrasonography"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence"},{"id":564955,"name":"Hiv seropositivity","url":"https://www.academia.edu/Documents/in/Hiv_seropositivity"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography"},{"id":1195615,"name":"Lymphatic Diseases","url":"https://www.academia.edu/Documents/in/Lymphatic_Diseases"},{"id":1653983,"name":"Abdomen","url":"https://www.academia.edu/Documents/in/Abdomen"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779405"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779405/Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection"><img alt="Research paper thumbnail of Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection" class="work-thumbnail" src="https://attachments.academia-assets.com/44963392/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779405/Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection">Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection</a></div><div class="wp-workCard_item"><span>Scandinavian Journal of Infectious Diseases</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodefic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodeficiency disorders, recent evidence would suggest a statistically significant increase in HD among individuals infected with human immunodeficiency virus (HIV). In the setting of underlying HIV infection, clinical and pathologic characteristics of HD may differ from usual expectations. Thus, 70%-100% of HIVinfected patients with HD present with systemic ''B'' symptoms. Likewise, disseminated, stage III or IV disease is reported in approximately 75%-90%. Bone marrow is a common site of extranodal HD, occurring in 40%-50%. Complete response rates after multiagent chemotherapy range from approximately 45% to 70%, although median survival has been only in the range of approximately 18 months. Hematologic toxicity from multiagent chemotherapy may be substantial, even with the use of hematopoietic growth factor support. It is apparent that new strategies of therapeutic intervention must be explored.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7f948b68a50ef0db14f46a90aa7869cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963392,"asset_id":13779405,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963392/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779405"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779405"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779405; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779405]").text(description); $(".js-view-count[data-work-id=13779405]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779405; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779405']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779405, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7f948b68a50ef0db14f46a90aa7869cd" } } $('.js-work-strip[data-work-id=13779405]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779405,"title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection","translated_title":"","metadata":{"grobid_abstract":"Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodeficiency disorders, recent evidence would suggest a statistically significant increase in HD among individuals infected with human immunodeficiency virus (HIV). In the setting of underlying HIV infection, clinical and pathologic characteristics of HD may differ from usual expectations. Thus, 70%-100% of HIVinfected patients with HD present with systemic ''B'' symptoms. Likewise, disseminated, stage III or IV disease is reported in approximately 75%-90%. Bone marrow is a common site of extranodal HD, occurring in 40%-50%. Complete response rates after multiagent chemotherapy range from approximately 45% to 70%, although median survival has been only in the range of approximately 18 months. Hematologic toxicity from multiagent chemotherapy may be substantial, even with the use of hematopoietic growth factor support. It is apparent that new strategies of therapeutic intervention must be explored.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Scandinavian Journal of Infectious Diseases","grobid_abstract_attachment_id":44963392},"translated_abstract":null,"internal_url":"https://www.academia.edu/13779405/Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection","translated_internal_url":"","created_at":"2015-07-07T22:10:48.722-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588328,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688650,"email":"m***i@med.unibo.it","display_order":0,"name":"R. Manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"},{"id":2588376,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688651,"email":"m***f@med.unibo.it","display_order":4194304,"name":"R. Manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"},{"id":2588434,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":13423734,"co_author_invite_id":688652,"email":"e***2@hotmail.it","display_order":6291456,"name":"roberto manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"},{"id":2588482,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688653,"email":"r***i@unibo.it","display_order":7340032,"name":"Roberto Manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"}],"downloadable_attachments":[{"id":44963392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963392/thumbnails/1.jpg","file_name":"37.pdf","download_url":"https://www.academia.edu/attachments/44963392/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hodgkins_Disease_in_the_Setting_of_Human.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963392/37-libre.pdf?1461264994=\u0026response-content-disposition=attachment%3B+filename%3DHodgkins_Disease_in_the_Setting_of_Human.pdf\u0026Expires=1734027728\u0026Signature=hFxGz~MpH51SK~G-K~8MJmunl3kHeh2gZb3jKOCZ2BZ3Pf2N~u4JuFQ7ktCXeiDpE7D9DnLJ2Ya4VKZwQW9Wqq3YkI6g232Z1UUY4CI6XSNfN~H-Q2z20BXiHX7BAKGZqRTzISAmFWsdoesQo7EOhp6sHejd1Yy846CIehHIMkE59LE~4I9r1DdDzxTZ5Jw3hfyUH91wmgUqN1feBaImWZA90cbPXxYHoFdB-jTjnT0qXR7qfXQ9IQzBdCdfWUVPMZ-QNK3BjC0Qi3R5lOM1SeQNwTsU~XFoRfhTBs7VS4TJrtdE3sNim6soPBRx3vROvCgQg3Itll9MkTfrwxCUcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodeficiency disorders, recent evidence would suggest a statistically significant increase in HD among individuals infected with human immunodeficiency virus (HIV). In the setting of underlying HIV infection, clinical and pathologic characteristics of HD may differ from usual expectations. Thus, 70%-100% of HIVinfected patients with HD present with systemic ''B'' symptoms. Likewise, disseminated, stage III or IV disease is reported in approximately 75%-90%. Bone marrow is a common site of extranodal HD, occurring in 40%-50%. Complete response rates after multiagent chemotherapy range from approximately 45% to 70%, although median survival has been only in the range of approximately 18 months. Hematologic toxicity from multiagent chemotherapy may be substantial, even with the use of hematopoietic growth factor support. It is apparent that new strategies of therapeutic intervention must be explored.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[{"id":44963392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963392/thumbnails/1.jpg","file_name":"37.pdf","download_url":"https://www.academia.edu/attachments/44963392/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hodgkins_Disease_in_the_Setting_of_Human.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963392/37-libre.pdf?1461264994=\u0026response-content-disposition=attachment%3B+filename%3DHodgkins_Disease_in_the_Setting_of_Human.pdf\u0026Expires=1734027728\u0026Signature=hFxGz~MpH51SK~G-K~8MJmunl3kHeh2gZb3jKOCZ2BZ3Pf2N~u4JuFQ7ktCXeiDpE7D9DnLJ2Ya4VKZwQW9Wqq3YkI6g232Z1UUY4CI6XSNfN~H-Q2z20BXiHX7BAKGZqRTzISAmFWsdoesQo7EOhp6sHejd1Yy846CIehHIMkE59LE~4I9r1DdDzxTZ5Jw3hfyUH91wmgUqN1feBaImWZA90cbPXxYHoFdB-jTjnT0qXR7qfXQ9IQzBdCdfWUVPMZ-QNK3BjC0Qi3R5lOM1SeQNwTsU~XFoRfhTBs7VS4TJrtdE3sNim6soPBRx3vROvCgQg3Itll9MkTfrwxCUcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity"},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":210665,"name":"Infectious","url":"https://www.academia.edu/Documents/in/Infectious"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":318308,"name":"Human immunodeficiency virus","url":"https://www.academia.edu/Documents/in/Human_immunodeficiency_virus"},{"id":462473,"name":"Highly Active Antiretroviral Therapy","url":"https://www.academia.edu/Documents/in/Highly_Active_Antiretroviral_Therapy"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":1350756,"name":"Hodgkin disease","url":"https://www.academia.edu/Documents/in/Hodgkin_disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779404"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779404/Voriconazole_Proves_Effective_in_Long_Term_Treatment_of_a_Cerebral_Cryptococcoma_in_a_Chronic_Nephropathic_HIV_Negative_Patient_after_Fluconazole_Failure"><img alt="Research paper thumbnail of Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure" class="work-thumbnail" src="https://attachments.academia-assets.com/44963402/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779404/Voriconazole_Proves_Effective_in_Long_Term_Treatment_of_a_Cerebral_Cryptococcoma_in_a_Chronic_Nephropathic_HIV_Negative_Patient_after_Fluconazole_Failure">Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure</a></div><div class="wp-workCard_item"><span>Mycopathologia</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of its relationship with a broadening range of risk factors, including malignancies, neutropenia, end-organ failure, bone marrow and solid-organ transplantation, and multiple underlying causes of primary-secondary immunodeficiency. A cerebral cryptococcoma in a chronic nephropathic HIV-negative subject with homocystinuria, completely cured with neurosurgery and voriconazole after fluconazole failure, is described.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="911dca90a55281dfab109b3f47fce80f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963402,"asset_id":13779404,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963402/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779404"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779404"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779404; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779404]").text(description); $(".js-view-count[data-work-id=13779404]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779404; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779404']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779404, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "911dca90a55281dfab109b3f47fce80f" } } $('.js-work-strip[data-work-id=13779404]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779404,"title":"Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure","translated_title":"","metadata":{"grobid_abstract":"Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of its relationship with a broadening range of risk factors, including malignancies, neutropenia, end-organ failure, bone marrow and solid-organ transplantation, and multiple underlying causes of primary-secondary immunodeficiency. A cerebral cryptococcoma in a chronic nephropathic HIV-negative subject with homocystinuria, completely cured with neurosurgery and voriconazole after fluconazole failure, is described.","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Mycopathologia","grobid_abstract_attachment_id":44963402},"translated_abstract":null,"internal_url":"https://www.academia.edu/13779404/Voriconazole_Proves_Effective_in_Long_Term_Treatment_of_a_Cerebral_Cryptococcoma_in_a_Chronic_Nephropathic_HIV_Negative_Patient_after_Fluconazole_Failure","translated_internal_url":"","created_at":"2015-07-07T22:10:48.639-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588331,"work_id":13779404,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688650,"email":"m***i@med.unibo.it","display_order":0,"name":"R. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3176051" id="papers"><div class="js-work-strip profile--work_container" data-work-id="13779423"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779423/Dyslipidaemia_associated_with_antiretroviral_therapy_in_HIV_infected_patients"><img alt="Research paper thumbnail of Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients" class="work-thumbnail" src="https://attachments.academia-assets.com/38125807/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779423/Dyslipidaemia_associated_with_antiretroviral_therapy_in_HIV_infected_patients">Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highly active antiretroviral therapy (HAART) has had a significant impact on the natural history ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highly active antiretroviral therapy (HAART) has had a significant impact on the natural history of human immunodeficiency virus (HIV) infection, leading to a remarkable decrease in its morbidity and mortality, but is frequently associated with clinical and metabolic complications. Fat redistribution or lipodystrophy, hypertriglyceridaemia, hypercholesterolaemia, insulin resistance and diabetes mellitus have been exten- sively reported in subjects treated with protease</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4efb1f39acadad13b4014d14a32b7e40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":38125807,"asset_id":13779423,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/38125807/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779423"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779423]").text(description); $(".js-view-count[data-work-id=13779423]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779423']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779423, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4efb1f39acadad13b4014d14a32b7e40" } } $('.js-work-strip[data-work-id=13779423]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779423,"title":"Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients","translated_title":"","metadata":{"abstract":"Highly active antiretroviral therapy (HAART) has had a significant impact on the natural history of human immunodeficiency virus (HIV) infection, leading to a remarkable decrease in its morbidity and mortality, but is frequently associated with clinical and metabolic complications. 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The only review on IRIS associated with Criptococcus neoformans reported 21 episodes including lymphadenitis, necrotizing pneumonitis, breast and cutaneous abscess, and cryptococcomas. To our knowledge this is the first report of IRIS associated with previous meningeal criptococcal infection which required neurosurgical intervention with placement of a ventriculo-peritoneal shunt to drain a CSF cyst formed by exclusion of the temporal horn of the right lateral ventricle. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779420"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779420/Human_herpesvirus_8_related_Kaposis_sarcoma_after_liver_transplantation_successfully_treated_with_cidofovir_and_liposomal_daunorubicin"><img alt="Research paper thumbnail of Human herpesvirus-8-related Kaposi's sarcoma after liver transplantation successfully treated with cidofovir and liposomal daunorubicin" class="work-thumbnail" src="https://attachments.academia-assets.com/44963401/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779420/Human_herpesvirus_8_related_Kaposis_sarcoma_after_liver_transplantation_successfully_treated_with_cidofovir_and_liposomal_daunorubicin">Human herpesvirus-8-related Kaposi's sarcoma after liver transplantation successfully treated with cidofovir and liposomal daunorubicin</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrancoTrevisani">Franco Trevisani</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a></span></div><div class="wp-workCard_item"><span>Transplant infectious disease : an official journal of the Transplantation Society</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The iatrogenic form of Kaposi&#39;s sarcoma (KS) is typically observed among transplant recipient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The iatrogenic form of Kaposi&#39;s sarcoma (KS) is typically observed among transplant recipients, and the most appropriate therapeutic approach (usually including reduction of immunosuppression, specific chemotherapy, and/or administration of antiviral agents against human herpes virus-8) is still controversial. Available experiences on the effect of the anti-herpes viruses drug cidofovir provide conflicting results. Herein, we report the clinical, histological, and virological features of a liver transplant recipient successfully treated with a combined therapy of cidofovir and liposomal daunorubicin, associated with a reduction of the immunosuppressive regimen, for an advanced cutaneous and visceral KS.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4031e00b279785e3ca992d736f6d23eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963401,"asset_id":13779420,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963401/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779420"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779420"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779420; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779420]").text(description); $(".js-view-count[data-work-id=13779420]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779420; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779420']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779420, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4031e00b279785e3ca992d736f6d23eb" } } $('.js-work-strip[data-work-id=13779420]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779420,"title":"Human herpesvirus-8-related Kaposi's sarcoma after liver transplantation successfully treated with cidofovir and liposomal daunorubicin","translated_title":"","metadata":{"abstract":"The iatrogenic form of Kaposi\u0026#39;s sarcoma (KS) is typically observed among transplant recipients, and the most appropriate therapeutic approach (usually including reduction of immunosuppression, specific chemotherapy, and/or administration of antiviral agents against human herpes virus-8) is still controversial. 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At present very limited information is available concerning its clinical significance in the setting of HIV infection. A retrospective survey of clinical and microbiological records of 1,374 HIV-infected patients referring to our tertiary care center during a 10-year period (1991-2000) was performed to identify all episodes of S. maltophilia infection and analyze epidemiological, clinical and laboratory variables. The episodes of S. maltophilia bacteremia were compared with those caused by non-typhoid Salmonella spp. occurring in HIV-infected patients referring to our center during the same period, in order to evaluate eventual predisposing risk factors. 61 episodes of S. maltophilia infection were observed in 59 HIV-infected patients: sepsis/bacteremia in 48 cases (78.7%), lower airways infe...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2ad46cd774f2f2aa0bf1633761f80d57" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963384,"asset_id":13779419,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963384/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779419"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779419]").text(description); $(".js-view-count[data-work-id=13779419]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779419']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779419, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2ad46cd774f2f2aa0bf1633761f80d57" } } $('.js-work-strip[data-work-id=13779419]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779419,"title":"Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: a 10-year surveillance study","translated_title":"","metadata":{"abstract":"Stenotrophomonas (Xanthomonas) maltophilia has been increasingly reported as a nosocomial opportunistic pathogen, responsible for serious infectious complications in immunocompromised patients. 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The episodes of S. maltophilia bacteremia were compared with those caused by non-typhoid Salmonella spp. occurring in HIV-infected patients referring to our center during the same period, in order to evaluate eventual predisposing risk factors. 61 episodes of S. maltophilia infection were observed in 59 HIV-infected patients: sepsis/bacteremia in 48 cases (78.7%), lower airways infe...","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Infection"},"translated_abstract":"Stenotrophomonas (Xanthomonas) maltophilia has been increasingly reported as a nosocomial opportunistic pathogen, responsible for serious infectious complications in immunocompromised patients. At present very limited information is available concerning its clinical significance in the setting of HIV infection. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779418"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779418/3_Azido_3_deoxythymidine_methotrexate_as_a_novel_antineoplastic_combination_in_the_treatment_of_human_immunodeficiency_virus_related_non_Hodgkins_lymphomas"><img alt="Research paper thumbnail of 3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779418/3_Azido_3_deoxythymidine_methotrexate_as_a_novel_antineoplastic_combination_in_the_treatment_of_human_immunodeficiency_virus_related_non_Hodgkins_lymphomas">3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ERaise">E. Raise</a></span></div><div class="wp-workCard_item"><span>Blood</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously reported that 3&#39;-azido 3&#39;-deoxythymidine (AZT) can possess a significa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously reported that 3&#39;-azido 3&#39;-deoxythymidine (AZT) can possess a significant antineoplastic activity when combined with drugs that disrupt de novo thymidylate synthesis, such as 5-fluorouracil and methotrexate (MTX). The aim of the present study was to evaluate the efficacy and the tolerance of the combination AZT + MTX in human immunodeficiency virus (HIV)-related non-Hodgkin&#39;s lymphoma (NHL). Twenty-nine patients (22 men and 7 women), either newly diagnosed or pretreated, have been enrolled in the trial; the median age was 34 years, 45% had acquired immunodeficiency syndrome before lymphoma and 19 patients had less than 100 CD4 lymphocytes/microL. Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. The treatment plan included three weekly courses of MTX at 1 g/m2 (days 1, 8, and 15) plus oral AZT at 2 g/m2 (days 1, 2, and 3), 4 g/m2 (days 8, 9, and 10), and 6 g/m2 (day...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779418"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779418"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779418; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779418]").text(description); $(".js-view-count[data-work-id=13779418]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779418; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779418']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779418, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13779418]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779418,"title":"3'-Azido 3'-deoxythymidine + methotrexate as a novel antineoplastic combination in the treatment of human immunodeficiency virus-related non-Hodgkin's lymphomas","translated_title":"","metadata":{"abstract":"We have previously reported that 3\u0026#39;-azido 3\u0026#39;-deoxythymidine (AZT) can possess a significant antineoplastic activity when combined with drugs that disrupt de novo thymidylate synthesis, such as 5-fluorouracil and methotrexate (MTX). The aim of the present study was to evaluate the efficacy and the tolerance of the combination AZT + MTX in human immunodeficiency virus (HIV)-related non-Hodgkin\u0026#39;s lymphoma (NHL). Twenty-nine patients (22 men and 7 women), either newly diagnosed or pretreated, have been enrolled in the trial; the median age was 34 years, 45% had acquired immunodeficiency syndrome before lymphoma and 19 patients had less than 100 CD4 lymphocytes/microL. Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. 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Histologic diagnoses were mainly Burkitt (27%) and diffuse large B-cell lymphoma (45%); extranodal involvement was present in 20 patients. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779416"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779416/Syndrome_of_recurrent_transient_neurological_deficits_in_patients_with_HIV_infection"><img alt="Research paper thumbnail of Syndrome of recurrent transient neurological deficits in patients with HIV infection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779416/Syndrome_of_recurrent_transient_neurological_deficits_in_patients_with_HIV_infection">Syndrome of recurrent transient neurological deficits in patients with HIV infection</a></div><div class="wp-workCard_item"><span>AIDS Research and Human Retroviruses</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779416"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779416"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779416; 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One hundred forty-nine of 366 (40.7%) and 171/366 (46.7%) samples tested positive by dipstick and serology, respectively. Dipstick sensitivity was calculated to be 84.8% (range between countries, 77.5 to 95%), and specificity was 97.9% (95.9 to 100%).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d6dcc0776542cffa9c39025f15c09b1f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963445,"asset_id":13779415,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963445/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779415"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779415"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779415; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779415]").text(description); $(".js-view-count[data-work-id=13779415]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779415; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779415']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779415, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d6dcc0776542cffa9c39025f15c09b1f" } } $('.js-work-strip[data-work-id=13779415]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779415,"title":"Prevalence of antiretroviral drug resistance in untreated persons newly diagnosed with HIV1 infection","translated_title":"","metadata":{"grobid_abstract":"We evaluated a commercially available immunochromatographic dipstick test to detect Trypanosoma cruzi infection in 366 human serum samples with known serological results from Argentina, Ecuador, Mexico, and Venezuela. 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wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779414/Streptococcus_bovis_Bacteremia_in_Patients_Infected_with_the_Human_Immunodeficiency_Virus_Case_Reports_and_Literature_Review">Streptococcus bovis Bacteremia in Patients Infected with the Human Immunodeficiency Virus: Case Reports and Literature Review</a></div><div class="wp-workCard_item"><span>European Journal of Clinical Microbiology & Infectious Diseases</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i 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Address correspondence and reprint requests to Leonardo Calza, MD, Department of Clinical and...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Address correspondence and reprint requests to Leonardo Calza, MD, Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna &quot;Alma Mater Studiorum,&quot; S. Orsola Hospital ... 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A randomised, multicentric study" class="work-thumbnail" src="https://attachments.academia-assets.com/44963383/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779410/Clinical_and_immunological_assessment_in_HIV_subjects_receiving_inosine_pranobex_A_randomised_multicentric_study">Clinical and immunological assessment in HIV+ subjects receiving inosine-pranobex. A randomised, multicentric study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ERaise">E. Raise</a></span></div><div class="wp-workCard_item"><span>Medical oncology and tumor pharmacotherapy</span><span>, 1989</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimeth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimethylamino-2-propanol and inosine in a 3:1 molar ratio. In early studies, INPX was found to partially inhibit human immunodeficiency virus (HIV) and to increase the immunocompetence of HIV-infected subjects in vitro. We report the results of a randomised, multicentric clinical trial carried out on 553 HIV+ patients. 261 individuals were treated with INPX (two 500 mg tablets every 6 h for 3 months) and the remaining 292 constituted the untreated control group. INPX treatment was associated with a slightly improved clinical condition or with a trend in that direction, as compared to the untreated group. A preservation of the CD4/CD8 cell ratio values, a decrease in the CD8+ cells and an increase in the Leu 2-7+ cell number better than in the untreated individuals was also observed in the patients taking INPX. No serious or adverse effects of INPX have been observed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="235fc041fe256df9f746f04fe05f8c35" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963383,"asset_id":13779410,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963383/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779410"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779410"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779410; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779410]").text(description); $(".js-view-count[data-work-id=13779410]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779410; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779410']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779410, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "235fc041fe256df9f746f04fe05f8c35" } } $('.js-work-strip[data-work-id=13779410]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779410,"title":"Clinical and immunological assessment in HIV+ subjects receiving inosine-pranobex. 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A randomised, multicentric study"}],"downloadable_attachments":[{"id":44963383,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963383/thumbnails/1.jpg","file_name":"bf02985225.pdf20160421-32534-nc0j60","download_url":"https://www.academia.edu/attachments/44963383/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_and_immunological_assessment_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963383/bf02985225-libre.pdf20160421-32534-nc0j60?1461264999=\u0026response-content-disposition=attachment%3B+filename%3DClinical_and_immunological_assessment_in.pdf\u0026Expires=1734027727\u0026Signature=ad6w2wxcMrQZyh1IqQt~dcGQ2bvR9IsBkCHdqjfpKliZCID6uMX4kDBjw8~dgdpj1~wgWsBDs2dviFvuf7EpqGzoE-P1UjQV1C5gx6qa2QFvicEJLm9FbhwqvKC8j5FHTHwl-7fadaKbc7MDQ9fj4xy0f05C4hOr7TCwt95FxWIqoxv5HkqYvO87IVY~vmrYQrgecjgYfJXGC8z5QmLKQfHYi~Y9NS1OEqBwAcS0jF5YeQ0JC2JpQFooc5dPY3vPOafhpq45pGCJGDl9c1iQYBuUrDIEuOHUSwr0VwgjS27vNdTW~SQCkj8rooWmcKeYZj2OduHtovEskvFZ~sAdew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_and_immunological_assessment_in_HIV_subjects_receiving_inosine_pranobex_A_randomised_multicentric_study","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimethylamino-2-propanol and inosine in a 3:1 molar ratio. In early studies, INPX was found to partially inhibit human immunodeficiency virus (HIV) and to increase the immunocompetence of HIV-infected subjects in vitro. We report the results of a randomised, multicentric clinical trial carried out on 553 HIV+ patients. 261 individuals were treated with INPX (two 500 mg tablets every 6 h for 3 months) and the remaining 292 constituted the untreated control group. INPX treatment was associated with a slightly improved clinical condition or with a trend in that direction, as compared to the untreated group. A preservation of the CD4/CD8 cell ratio values, a decrease in the CD8+ cells and an increase in the Leu 2-7+ cell number better than in the untreated individuals was also observed in the patients taking INPX. No serious or adverse effects of INPX have been observed.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[{"id":44963383,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963383/thumbnails/1.jpg","file_name":"bf02985225.pdf20160421-32534-nc0j60","download_url":"https://www.academia.edu/attachments/44963383/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_and_immunological_assessment_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963383/bf02985225-libre.pdf20160421-32534-nc0j60?1461264999=\u0026response-content-disposition=attachment%3B+filename%3DClinical_and_immunological_assessment_in.pdf\u0026Expires=1734027727\u0026Signature=ad6w2wxcMrQZyh1IqQt~dcGQ2bvR9IsBkCHdqjfpKliZCID6uMX4kDBjw8~dgdpj1~wgWsBDs2dviFvuf7EpqGzoE-P1UjQV1C5gx6qa2QFvicEJLm9FbhwqvKC8j5FHTHwl-7fadaKbc7MDQ9fj4xy0f05C4hOr7TCwt95FxWIqoxv5HkqYvO87IVY~vmrYQrgecjgYfJXGC8z5QmLKQfHYi~Y9NS1OEqBwAcS0jF5YeQ0JC2JpQFooc5dPY3vPOafhpq45pGCJGDl9c1iQYBuUrDIEuOHUSwr0VwgjS27vNdTW~SQCkj8rooWmcKeYZj2OduHtovEskvFZ~sAdew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":64900,"name":"Medical Oncology","url":"https://www.academia.edu/Documents/in/Medical_Oncology"},{"id":160242,"name":"Hiv Infection","url":"https://www.academia.edu/Documents/in/Hiv_Infection"},{"id":318308,"name":"Human immunodeficiency virus","url":"https://www.academia.edu/Documents/in/Human_immunodeficiency_virus"},{"id":1622318,"name":"Antiviral Agents","url":"https://www.academia.edu/Documents/in/Antiviral_Agents"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779409"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779409/Preliminary_observations_using_HIV_specific_transfer_factor_in_AIDS"><img alt="Research paper thumbnail of Preliminary observations using HIV-specific transfer factor in AIDS" class="work-thumbnail" src="https://attachments.academia-assets.com/44963379/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779409/Preliminary_observations_using_HIV_specific_transfer_factor_in_AIDS">Preliminary observations using HIV-specific transfer factor in AIDS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://unibo.academia.edu/FrancescoChiodo">Francesco Chiodo</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ERaise">E. Raise</a></span></div><div class="wp-workCard_item"><span>Biotherapy</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally w...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with 'IF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25 patients the number of Iymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting further investigation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dc6ad6753327cc6ed13a070cd3af2e5a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963379,"asset_id":13779409,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963379/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779409"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779409"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779409; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779409]").text(description); $(".js-view-count[data-work-id=13779409]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779409; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779409']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779409, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dc6ad6753327cc6ed13a070cd3af2e5a" } } $('.js-work-strip[data-work-id=13779409]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779409,"title":"Preliminary observations using HIV-specific transfer factor in AIDS","translated_title":"","metadata":{"grobid_abstract":"Twenty five HIV-1-infected patients, at various stages (CDC II, III and IV) were treated orally with HIV-1-specific transfer factor (TF) for periods varying from 60 to 1870 days. All patients were receiving antiviral treatments in association with 'IF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25 patients the number of Iymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting further investigation.","publication_date":{"day":null,"month":null,"year":1996,"errors":{}},"publication_name":"Biotherapy","grobid_abstract_attachment_id":44963379},"translated_abstract":null,"internal_url":"https://www.academia.edu/13779409/Preliminary_observations_using_HIV_specific_transfer_factor_in_AIDS","translated_internal_url":"","created_at":"2015-07-07T22:10:49.063-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588553,"work_id":13779409,"tagging_user_id":32888829,"tagged_user_id":32949890,"co_author_invite_id":688661,"email":"e***e@libero.it","display_order":0,"name":"E. 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All patients were receiving antiviral treatments in association with 'IF. The number of lymphocytes, CD4 and CD8 subsets were followed and showed no statistically significant variations. In 11/25 patients the number of Iymphocytes increased, whilst in 11/25 decreased; similarly an increase of the CD4 lymphocytes was observed in 11/25 patients and of the CD8 lymphocytes in 15/25. Clinical improvement or a stabilized clinical condition was noticed in 20/25 patients, whilst a deterioration was seen in 5/25. In 12/14 anergic patients, daily TF administration restored delayed type hypersensitivity to recall antigens within 60 days. These preliminary observations suggest that oral HIV-specific TF administration, in association with antiviral drugs, is well tolerated and seems beneficial to AIDS patients, thus warranting further investigation.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[{"id":44963379,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963379/thumbnails/1.jpg","file_name":"09e4150f1b7a6437df000000.pdf_ev_pub_ext_doc_dl_meta","download_url":"https://www.academia.edu/attachments/44963379/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Preliminary_observations_using_HIV_speci.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963379/09e4150f1b7a6437df000000-libre.pdf_ev_pub_ext_doc_dl_meta?1461264996=\u0026response-content-disposition=attachment%3B+filename%3DPreliminary_observations_using_HIV_speci.pdf\u0026Expires=1734027728\u0026Signature=a0ThN-DmXjnqRlqfsZpsM-lMoXTP57FmyuBVU2hHRI8oawLTttNoWuNNUI8rgbJm87zOv5niQgW59PNeMB8UQRb-lu0mAjo6C5noyi~McbQJVZ1bDP9frf7842Tqgyaj4~KNhnHyxeK2IESFuQjZZgigcUO2eHOmKvezl193IPqXvN8O5YfUCN~KDHLVek5SvIqmRLDawzhiTj9la6hfU47rz1HlNdMHD0wJ7-pQruWV91oZyfp8ExVVClY5eXbwo2F-Tn3c~oJiUo3QowJQtwF3~Rz9Qcakny7iBEv~80gcm7NVIVbMox3BGMBvUx2NYoKB3qU5T9uRdb1hbuoZGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":125564,"name":"Statistical Significance","url":"https://www.academia.edu/Documents/in/Statistical_Significance"},{"id":596568,"name":"Transfer Factor","url":"https://www.academia.edu/Documents/in/Transfer_Factor"},{"id":643875,"name":"Biotherapy","url":"https://www.academia.edu/Documents/in/Biotherapy"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779408"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779408/The_need_for_transplantation_of_HIV_positive_subjects_in_Italy"><img alt="Research paper thumbnail of The need for transplantation of HIV-positive subjects in Italy" class="work-thumbnail" src="https://attachments.academia-assets.com/44963412/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779408/The_need_for_transplantation_of_HIV_positive_subjects_in_Italy">The need for transplantation of HIV-positive subjects in Italy</a></div><div class="wp-workCard_item"><span>Transplantation Proceedings</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb82e4891423870ab6316a4b219d554b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963412,"asset_id":13779408,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963412/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779408"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779408"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779408; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779408]").text(description); $(".js-view-count[data-work-id=13779408]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779408; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779408']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779408, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The research, involving multiple Italian infectious disease units, emphasizes the pressing necessity to reevaluate the historical exclusion of HIV-positive patients from transplant programs, outlining specific criteria that affect their eligibility. 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The retrieval of a chest radiograph incidentally performed 11 y before and showing a probable primary tuberculosis, paralleled a negligible clinical history. The enlargement of interferon indications needs careful evaluation for prior (usually missed) tuberculosis, to prevent or avoid its possible reactivation. 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Computerized tomography, performed in 10 cases of lymphadenopathy, invariably confirmed the UlS findings. Prevalence [asymptomatic carriers: 8/15 (53%); PGL patients: 8/18 (44%); ARC: 13/27 (48%); AIDS: 12/25 (48%)], number, size, and site of deep nodes were comparable among the different CDC groups. No correlation was found between abdominal and superficial lymphadenopathy. Median serum concentrations of gammaglobulins (g/dl) and IgG (mg/dl) were higher in patients with than without deep nodes (2.25 vs 1.87 and 2540 vs 1900, respectively) (p &amp;lt; 0.01) as well as in cases with than without superficial nodes (2.15 vs 1.80 and 2340 vs 1941, respectively) (p &amp;lt; 0.05). Abdominal lymphadenopathy occurred during all stages of HIV infection even in asymptomatic carriers: this should be considered in the differential diagnosis of UlS-detected deep nodes. 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Enlargement of either deep or superficial nodes seems to reflect a state of polyclonal B cell activation.","internal_url":"https://www.academia.edu/13779406/Abdominal_Lymphadenopathy_Detected_by_Ultrasonography_in_HIV_1_Infection_Prevalence_and_Significance","translated_internal_url":"","created_at":"2015-07-07T22:10:48.813-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588517,"work_id":13779406,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688656,"email":"p***t@med.unibo.it","display_order":0,"name":"Paolo Costigliola","title":"Abdominal Lymphadenopathy Detected by Ultrasonography in HIV-1 Infection: Prevalence and Significance"},{"id":2588546,"work_id":13779406,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":112913,"email":"e***c@ebab.com","display_order":4194304,"name":"Ennio Ricchi","title":"Abdominal Lymphadenopathy Detected by Ultrasonography in HIV-1 Infection: Prevalence and Significance"}],"downloadable_attachments":[],"slug":"Abdominal_Lymphadenopathy_Detected_by_Ultrasonography_in_HIV_1_Infection_Prevalence_and_Significance","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"By using abdominal ultrasonography (UlS), deep nodes were detected in 41 of 85 (48%) HIV-1 positive subjects, most of them heroin addicts, but in none of 85 healthy HIV-negative controls. Computerized tomography, performed in 10 cases of lymphadenopathy, invariably confirmed the UlS findings. Prevalence [asymptomatic carriers: 8/15 (53%); PGL patients: 8/18 (44%); ARC: 13/27 (48%); AIDS: 12/25 (48%)], number, size, and site of deep nodes were comparable among the different CDC groups. No correlation was found between abdominal and superficial lymphadenopathy. Median serum concentrations of gammaglobulins (g/dl) and IgG (mg/dl) were higher in patients with than without deep nodes (2.25 vs 1.87 and 2540 vs 1900, respectively) (p \u0026amp;lt; 0.01) as well as in cases with than without superficial nodes (2.15 vs 1.80 and 2340 vs 1941, respectively) (p \u0026amp;lt; 0.05). Abdominal lymphadenopathy occurred during all stages of HIV infection even in asymptomatic carriers: this should be considered in the differential diagnosis of UlS-detected deep nodes. Enlargement of either deep or superficial nodes seems to reflect a state of polyclonal B cell activation.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[],"research_interests":[{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":39978,"name":"HIV","url":"https://www.academia.edu/Documents/in/HIV"},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy"},{"id":90702,"name":"Ultrasonography","url":"https://www.academia.edu/Documents/in/Ultrasonography"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence"},{"id":564955,"name":"Hiv seropositivity","url":"https://www.academia.edu/Documents/in/Hiv_seropositivity"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography"},{"id":1195615,"name":"Lymphatic Diseases","url":"https://www.academia.edu/Documents/in/Lymphatic_Diseases"},{"id":1653983,"name":"Abdomen","url":"https://www.academia.edu/Documents/in/Abdomen"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779405"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779405/Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection"><img alt="Research paper thumbnail of Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection" class="work-thumbnail" src="https://attachments.academia-assets.com/44963392/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779405/Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection">Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection</a></div><div class="wp-workCard_item"><span>Scandinavian Journal of Infectious Diseases</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodefic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodeficiency disorders, recent evidence would suggest a statistically significant increase in HD among individuals infected with human immunodeficiency virus (HIV). In the setting of underlying HIV infection, clinical and pathologic characteristics of HD may differ from usual expectations. Thus, 70%-100% of HIVinfected patients with HD present with systemic ''B'' symptoms. Likewise, disseminated, stage III or IV disease is reported in approximately 75%-90%. Bone marrow is a common site of extranodal HD, occurring in 40%-50%. Complete response rates after multiagent chemotherapy range from approximately 45% to 70%, although median survival has been only in the range of approximately 18 months. Hematologic toxicity from multiagent chemotherapy may be substantial, even with the use of hematopoietic growth factor support. It is apparent that new strategies of therapeutic intervention must be explored.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7f948b68a50ef0db14f46a90aa7869cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963392,"asset_id":13779405,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963392/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779405"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779405"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779405; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779405]").text(description); $(".js-view-count[data-work-id=13779405]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779405; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779405']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779405, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7f948b68a50ef0db14f46a90aa7869cd" } } $('.js-work-strip[data-work-id=13779405]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779405,"title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection","translated_title":"","metadata":{"grobid_abstract":"Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodeficiency disorders, recent evidence would suggest a statistically significant increase in HD among individuals infected with human immunodeficiency virus (HIV). In the setting of underlying HIV infection, clinical and pathologic characteristics of HD may differ from usual expectations. Thus, 70%-100% of HIVinfected patients with HD present with systemic ''B'' symptoms. Likewise, disseminated, stage III or IV disease is reported in approximately 75%-90%. Bone marrow is a common site of extranodal HD, occurring in 40%-50%. Complete response rates after multiagent chemotherapy range from approximately 45% to 70%, although median survival has been only in the range of approximately 18 months. Hematologic toxicity from multiagent chemotherapy may be substantial, even with the use of hematopoietic growth factor support. It is apparent that new strategies of therapeutic intervention must be explored.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Scandinavian Journal of Infectious Diseases","grobid_abstract_attachment_id":44963392},"translated_abstract":null,"internal_url":"https://www.academia.edu/13779405/Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection","translated_internal_url":"","created_at":"2015-07-07T22:10:48.722-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588328,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688650,"email":"m***i@med.unibo.it","display_order":0,"name":"R. Manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"},{"id":2588376,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688651,"email":"m***f@med.unibo.it","display_order":4194304,"name":"R. Manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"},{"id":2588434,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":13423734,"co_author_invite_id":688652,"email":"e***2@hotmail.it","display_order":6291456,"name":"roberto manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"},{"id":2588482,"work_id":13779405,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688653,"email":"r***i@unibo.it","display_order":7340032,"name":"Roberto Manfredi","title":"Hodgkin's Disease in the Setting of Human Immunodeficiency Virus Infection"}],"downloadable_attachments":[{"id":44963392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963392/thumbnails/1.jpg","file_name":"37.pdf","download_url":"https://www.academia.edu/attachments/44963392/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hodgkins_Disease_in_the_Setting_of_Human.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963392/37-libre.pdf?1461264994=\u0026response-content-disposition=attachment%3B+filename%3DHodgkins_Disease_in_the_Setting_of_Human.pdf\u0026Expires=1734027728\u0026Signature=hFxGz~MpH51SK~G-K~8MJmunl3kHeh2gZb3jKOCZ2BZ3Pf2N~u4JuFQ7ktCXeiDpE7D9DnLJ2Ya4VKZwQW9Wqq3YkI6g232Z1UUY4CI6XSNfN~H-Q2z20BXiHX7BAKGZqRTzISAmFWsdoesQo7EOhp6sHejd1Yy846CIehHIMkE59LE~4I9r1DdDzxTZ5Jw3hfyUH91wmgUqN1feBaImWZA90cbPXxYHoFdB-jTjnT0qXR7qfXQ9IQzBdCdfWUVPMZ-QNK3BjC0Qi3R5lOM1SeQNwTsU~XFoRfhTBs7VS4TJrtdE3sNim6soPBRx3vROvCgQg3Itll9MkTfrwxCUcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Hodgkins_Disease_in_the_Setting_of_Human_Immunodeficiency_Virus_Infection","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"Although Hodgkin's disease (HD) is not usually associated with congenital or acquired immunodeficiency disorders, recent evidence would suggest a statistically significant increase in HD among individuals infected with human immunodeficiency virus (HIV). In the setting of underlying HIV infection, clinical and pathologic characteristics of HD may differ from usual expectations. Thus, 70%-100% of HIVinfected patients with HD present with systemic ''B'' symptoms. Likewise, disseminated, stage III or IV disease is reported in approximately 75%-90%. Bone marrow is a common site of extranodal HD, occurring in 40%-50%. Complete response rates after multiagent chemotherapy range from approximately 45% to 70%, although median survival has been only in the range of approximately 18 months. Hematologic toxicity from multiagent chemotherapy may be substantial, even with the use of hematopoietic growth factor support. It is apparent that new strategies of therapeutic intervention must be explored.","owner":{"id":32888829,"first_name":"Francesco","middle_initials":"","last_name":"Chiodo","page_name":"FrancescoChiodo","domain_name":"unibo","created_at":"2015-07-07T22:10:08.940-07:00","display_name":"Francesco Chiodo","url":"https://unibo.academia.edu/FrancescoChiodo"},"attachments":[{"id":44963392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44963392/thumbnails/1.jpg","file_name":"37.pdf","download_url":"https://www.academia.edu/attachments/44963392/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hodgkins_Disease_in_the_Setting_of_Human.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44963392/37-libre.pdf?1461264994=\u0026response-content-disposition=attachment%3B+filename%3DHodgkins_Disease_in_the_Setting_of_Human.pdf\u0026Expires=1734027728\u0026Signature=hFxGz~MpH51SK~G-K~8MJmunl3kHeh2gZb3jKOCZ2BZ3Pf2N~u4JuFQ7ktCXeiDpE7D9DnLJ2Ya4VKZwQW9Wqq3YkI6g232Z1UUY4CI6XSNfN~H-Q2z20BXiHX7BAKGZqRTzISAmFWsdoesQo7EOhp6sHejd1Yy846CIehHIMkE59LE~4I9r1DdDzxTZ5Jw3hfyUH91wmgUqN1feBaImWZA90cbPXxYHoFdB-jTjnT0qXR7qfXQ9IQzBdCdfWUVPMZ-QNK3BjC0Qi3R5lOM1SeQNwTsU~XFoRfhTBs7VS4TJrtdE3sNim6soPBRx3vROvCgQg3Itll9MkTfrwxCUcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity"},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":210665,"name":"Infectious","url":"https://www.academia.edu/Documents/in/Infectious"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":318308,"name":"Human immunodeficiency virus","url":"https://www.academia.edu/Documents/in/Human_immunodeficiency_virus"},{"id":462473,"name":"Highly Active Antiretroviral Therapy","url":"https://www.academia.edu/Documents/in/Highly_Active_Antiretroviral_Therapy"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":1350756,"name":"Hodgkin disease","url":"https://www.academia.edu/Documents/in/Hodgkin_disease"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13779404"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13779404/Voriconazole_Proves_Effective_in_Long_Term_Treatment_of_a_Cerebral_Cryptococcoma_in_a_Chronic_Nephropathic_HIV_Negative_Patient_after_Fluconazole_Failure"><img alt="Research paper thumbnail of Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure" class="work-thumbnail" src="https://attachments.academia-assets.com/44963402/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13779404/Voriconazole_Proves_Effective_in_Long_Term_Treatment_of_a_Cerebral_Cryptococcoma_in_a_Chronic_Nephropathic_HIV_Negative_Patient_after_Fluconazole_Failure">Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure</a></div><div class="wp-workCard_item"><span>Mycopathologia</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of its relationship with a broadening range of risk factors, including malignancies, neutropenia, end-organ failure, bone marrow and solid-organ transplantation, and multiple underlying causes of primary-secondary immunodeficiency. A cerebral cryptococcoma in a chronic nephropathic HIV-negative subject with homocystinuria, completely cured with neurosurgery and voriconazole after fluconazole failure, is described.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="911dca90a55281dfab109b3f47fce80f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44963402,"asset_id":13779404,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44963402/download_file?st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&st=MTczNDAyNDEyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13779404"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13779404"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13779404; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13779404]").text(description); $(".js-view-count[data-work-id=13779404]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13779404; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13779404']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13779404, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "911dca90a55281dfab109b3f47fce80f" } } $('.js-work-strip[data-work-id=13779404]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13779404,"title":"Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure","translated_title":"","metadata":{"grobid_abstract":"Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of its relationship with a broadening range of risk factors, including malignancies, neutropenia, end-organ failure, bone marrow and solid-organ transplantation, and multiple underlying causes of primary-secondary immunodeficiency. A cerebral cryptococcoma in a chronic nephropathic HIV-negative subject with homocystinuria, completely cured with neurosurgery and voriconazole after fluconazole failure, is described.","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Mycopathologia","grobid_abstract_attachment_id":44963402},"translated_abstract":null,"internal_url":"https://www.academia.edu/13779404/Voriconazole_Proves_Effective_in_Long_Term_Treatment_of_a_Cerebral_Cryptococcoma_in_a_Chronic_Nephropathic_HIV_Negative_Patient_after_Fluconazole_Failure","translated_internal_url":"","created_at":"2015-07-07T22:10:48.639-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32888829,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2588331,"work_id":13779404,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688650,"email":"m***i@med.unibo.it","display_order":0,"name":"R. Manfredi","title":"Voriconazole Proves Effective in Long-Term Treatment of a Cerebral Cryptococcoma in a Chronic Nephropathic HIV-Negative Patient, after Fluconazole Failure"},{"id":2588379,"work_id":13779404,"tagging_user_id":32888829,"tagged_user_id":null,"co_author_invite_id":688651,"email":"m***f@med.unibo.it","display_order":4194304,"name":"R. 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