CINXE.COM

IL-12 Family Signaling Pathways: R&D Systems

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<form id="pathways_il-17_family_signaling_pathways" action="/pathways/il17-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il17-family-signaling-pathways" class="pathway_link" data-form="pathways_il-17_family_signaling_pathways"> IL-17 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-2_signaling_pathways" action="/pathways/il2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il2-signaling-pathways" class="pathway_link" data-form="pathways_il-2_signaling_pathways"> IL-2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-2_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-2-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a 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href="/pathways/il-21-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-27_p28_il-30_signaling_pathways" action="/pathways/il-27-p28il-30-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-27-p28il-30-signaling-pathways" class="pathway_link" data-form="pathways_il-27_p28_il-30_signaling_pathways"> IL-27 p28/IL-30 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-31_signaling_pathways" action="/pathways/il-31-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-31-signaling-pathways" class="pathway_link" data-form="pathways_il-31_signaling_pathways"> IL-31 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways" action="/pathways/il4-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il4-signaling-pathways" class="pathway_link" data-form="pathways_il-4_signaling_pathways"> IL-4 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-6_signaling_pathways" action="/pathways/il-6-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-6-family-signaling-pathways" class="pathway_link" data-form="pathways_il-6_signaling_pathways"> IL-6 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways" action="/pathways/il7-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il7-signaling-pathways" class="pathway_link" data-form="pathways_il-7_signaling_pathways"> IL-7 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways" action="/pathways/il9-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il9-signaling-pathways" class="pathway_link" data-form="pathways_il-9_signaling_pathways"> IL-9 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_inflammasome_activation_pathways" action="/pathways/inflammasome-activation-pathways" method="post"> <li class=""> <a href="/pathways/inflammasome-activation-pathways" class="pathway_link" data-form="pathways_inflammasome_activation_pathways"> Inflammasome Activation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_innate_lymphoid_cell_differentiation_pathways" action="/pathways/innate-lymphoid-cell-differentiation-pathways" method="post"> <li class=""> <a href="/pathways/innate-lymphoid-cell-differentiation-pathways" class="pathway_link" data-form="pathways_innate_lymphoid_cell_differentiation_pathways"> Innate Lymphoid Cell Differentiation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_lif_signaling_pathways" action="/pathways/lif-signaling-pathways" method="post"> <li class=""> <a href="/pathways/lif-signaling-pathways" class="pathway_link" data-form="pathways_lif_signaling_pathways"> LIF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mdsc-mediated_mechanisms_of_immunosuppression" action="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" method="post"> <li class=""> <a href="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" class="pathway_link" data-form="pathways_mdsc-mediated_mechanisms_of_immunosuppression"> MDSC-Mediated Mechanisms of Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression" action="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" method="post"> <li class=""> <a href="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" class="pathway_link" data-form="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression"> Mechanisms of Regulatory T Cell-Mediated Suppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression" action="/pathways/tumor-associated-macrophage-tam" method="post"> <li class=""> <a href="/pathways/tumor-associated-macrophage-tam" class="pathway_link" data-form="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression"> Mechanisms of Tumor-Associated Macrophage TAM-Mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression" action="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" method="post"> <li class=""> <a href="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" class="pathway_link" data-form="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression"> Mechanisms of Tumor-derived Exosome TEX-mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions" action="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" method="post"> <li class=""> <a href="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" class="pathway_link" data-form="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions"> Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_neuropoietin_signaling_pathways" action="/pathways/neuropoietin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/neuropoietin-signaling-pathways" class="pathway_link" data-form="pathways_neuropoietin_signaling_pathways"> Neuropoietin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_nod-like_receptor_signaling_pathways" action="/pathways/nod-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/nod-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_nod-like_receptor_signaling_pathways"> NOD-like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_oncostatin_m_signaling_pathways" action="/pathways/oncostatin-m-signaling-pathways" method="post"> <li class=""> <a href="/pathways/oncostatin-m-signaling-pathways" class="pathway_link" data-form="pathways_oncostatin_m_signaling_pathways"> Oncostatin M Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways" action="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" class="pathway_link" data-form="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways"> Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions" action="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" class="pathway_link" data-form="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions"> T Cell Co-Signaling Pathway: Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tgf-beta_signaling_pathways" action="/pathways/tgf-beta-signaling-pathways" method="post"> <li class=""> <a href="/pathways/tgf-beta-signaling-pathways" class="pathway_link" data-form="pathways_tgf-beta_signaling_pathways"> TGF-beta Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th1_differentiation_pathway" action="/pathways/th1-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th1-differentiation-pathway" class="pathway_link" data-form="pathways_th1_differentiation_pathway"> Th1 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th17_differentiation_pathway" action="/pathways/th17-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th17-differentiation-pathway" class="pathway_link" data-form="pathways_th17_differentiation_pathway"> Th17 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th2_differentiation_pathway" action="/pathways/th2-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th2-differentiation-pathway" class="pathway_link" data-form="pathways_th2_differentiation_pathway"> Th2 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions" action="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" method="post"> <li class=""> <a href="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" class="pathway_link" data-form="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions"> TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_toll-like_receptor_signaling_pathways" action="/pathways/toll-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/toll-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_toll-like_receptor_signaling_pathways"> Toll-Like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_i_interferon_signaling_pathways" action="/pathways/type-i-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-i-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_i_interferon_signaling_pathways"> Type I Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_ii_interferon_signaling_pathways" action="/pathways/type-ii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-ii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_ii_interferon_signaling_pathways"> Type II Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_iii_interferon_signaling_pathways" action="/pathways/type-iii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-iii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_iii_interferon_signaling_pathways"> Type III Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_vegf_-_vegf_r2_signaling_pathways" action="/pathways/vegf-vegf-r2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/vegf-vegf-r2-signaling-pathways" class="pathway_link" data-form="pathways_vegf_-_vegf_r2_signaling_pathways"> VEGF - VEGF R2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr" action="/pathways/rig-i-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/rig-i-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr"> Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> </ul> </li> <li class="pathways-li "> <form id="pathways_neuroscience_pathways" action="/pathways/neuroscience" method="post"> <a href="/pathways/neuroscience" data-form="pathways_neuroscience_pathways" class="pathway_link"> <span class="icon-"> Neuroscience Pathways </span> </a> <input type="hidden" name="pw_parent" value="Neuroscience"> </form> </li> <li class="pathways-li "> <form id="pathways_proteases__other_enzymes_pathways" action="/pathways/proteases" method="post"> <a href="/pathways/proteases" data-form="pathways_proteases__other_enzymes_pathways" class="pathway_link"> <span class="icon-"> Proteases & Other Enzymes Pathways </span> </a> <input type="hidden" name="pw_parent" value="proteases"> </form> </li> <li class="pathways-li "> <form id="pathways_signal_transduction_pathways" action="/pathways/signal-transduction" method="post"> <a href="/pathways/signal-transduction" data-form="pathways_signal_transduction_pathways" class="pathway_link"> <span class="icon-"> Signal Transduction Pathways </span> </a> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> </li> <li class="pathways-li "> <form id="pathways_stem_cell_pathways" action="/pathways/stem-cells" method="post"> <a href="/pathways/stem-cells" data-form="pathways_stem_cell_pathways" class="pathway_link"> <span class="icon-"> Stem Cell Pathways </span> </a> <input type="hidden" name="pw_parent" value="stem-cells"> </form> </li> <li class="pathways-li "> <form id="pathways_ubiquitin_related_modifiers__pathways" action="/pathways/ubiquitin-related-modifiers-and-pathways" method="post"> <a href="/pathways/ubiquitin-related-modifiers-and-pathways" data-form="pathways_ubiquitin_related_modifiers__pathways" class="pathway_link"> <span class="icon-"> Ubiquitin, Related Modifiers, & Pathways </span> </a> <input type="hidden" name="pw_parent" value="ubiquitin-related-modifiers-and-pathways"> </form> </li> </ul> </div> </div> </div> </div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>IL-12 Family Signaling Pathways</h1> <p id="pw-intro-txt">Click on one of the IL-12 family cytokines shown in the Explore Pathways box below to see a list of select ligand-producing cells, major target cells, and the primary biological effects induced by each cytokine.<br></p> <div id="pw-con" data-mapname="" data-primary_segment="il-12signaling_ail"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"> <li data-segment="il-12Signaling_il-12" data-background_image="il-12-static.png" data-pathway_segment="Pathway_il-12Signaling_il-12" class="pw_rdblue_sm pw_sm_btn"><span>IL-12</span></li> <li data-segment="il-12Signaling_il-23" data-background_image="il-23-static.png" data-pathway_segment="Pathway_il-12Signaling_il-23" class="pw_rdblue_sm pw_sm_btn"><span>IL-23</span></li> <li data-segment="il-12Signaling_il-27" data-background_image="il-27-static.png" data-pathway_segment="Pathway_il-12Signaling_il-27" class="pw_rdblue_sm pw_sm_btn"><span>IL-27</span></li> <li data-segment="il-12Signaling_il-35" data-background_image="il-35-static.png?t=2" data-pathway_segment="Pathway_il-12Signaling_il-35" class="pw_rdblue_sm pw_sm_btn"><span>IL-35</span></li> <li data-segment="il-12Signaling_il-39" data-background_image="il-39-static.png?t=2" data-pathway_segment="Pathway_il-12Signaling_il-39" class="pw_rdblue_sm pw_sm_btn"><span>IL-39</span></li> <li data-segment="il-12Signaling_all" data-background_image="il-12-family-static-color.png" data-pathway_segment="Pathway_il-12Signaling_allshowDivnull" class="pw_sm_btn-active"><span>View Full Pathway</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> IL-12 Family Signaling Pathways </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray1 pw-gray" style="top:52.00001525878906px;left:42.6666259765625px;"> IL-12 </div> <div id="el1_off" data-id="1" data-set="IL-121" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off1" style="top:52.00001525878906px;left:42.6666259765625px;"> IL-12</div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12">IL-12</a><br><a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br><a href="https://www.rndsystems.com/search?common_name=IL-12/IL-23 p40">IL-12/IL-23 p40</a><br><a href="https://www.rndsystems.com/search?common_name=IL-12 p70">IL-12 p70</a><br> </div> </div> <div id="el2_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray2 pw-gray" style="top:65.33332824707031px;left:42.6666259765625px;"> </div> <div id="el2_off" data-id="2" data-set="p352" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off2" style="top:65.33332824707031px;left:42.6666259765625px;"> </div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br> </div> </div> <div id="el3_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray3 pw-gray" style="top:68.66667175292969px;left:24.6666259765625px;"> p35 </div> <div id="el3_off" data-id="3" data-set="p352" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off3" style="top:68.66667175292969px;left:24.6666259765625px;"> p35</div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br> </div> </div> <div id="el4_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray4 pw-gray" style="top:64.66667175292969px;left:45.6666259765625px;"> </div> <div id="el4_off" data-id="4" data-set="p403" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off4" style="top:64.66667175292969px;left:45.6666259765625px;"> </div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el5_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray5 pw-gray" style="top:75.33332824707031px;left:59.6666259765625px;"> p40 </div> <div id="el5_off" data-id="5" data-set="p403" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off5" style="top:75.33332824707031px;left:59.6666259765625px;"> p40</div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el6_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray6 pw-gray" style="top:133.6666717529297px;left:48.6666259765625px;"> </div> <div id="el6_off" data-id="6" data-set="IL-12Rbeta14" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off6" style="top:133.6666717529297px;left:48.6666259765625px;"> </div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 1">IL-12 R beta 1</a><br> </div> </div> <div id="el7_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray7 pw-gray" style="top:159.6666717529297px;left:67.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 1</div> </div> <div id="el7_off" data-id="7" data-set="IL-12Rbeta14" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off7" style="top:159.6666717529297px;left:67.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 1</div></div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 1">IL-12 R beta 1</a><br> </div> </div> <div id="el8_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray8 pw-gray" style="top:120.00000381469727px;left:36.6666259765625px;"> </div> <div id="el8_off" data-id="8" data-set="IL-12Rbeta25" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off8" style="top:120.00000381469727px;left:36.6666259765625px;"> </div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 2">IL-12 R beta 2</a><br> </div> </div> <div id="el9_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray9 pw-gray" style="top:159.666px;left:0.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 2</div> </div> <div id="el9_off" data-id="9" data-set="IL-12Rbeta25" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off9" style="top:159.666px;left:0.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 2</div></div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 2">IL-12 R beta 2</a><br> </div> </div> <div id="el10_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray10 pw-gray" style="top:231.00000762939453px;left:61.6666259765625px;"> </div> <div id="el10_off" data-id="10" data-set="Tyk26" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off10" style="top:231.00000762939453px;left:61.6666259765625px;"> </div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el11_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray11 pw-gray" style="top:245.66667938232422px;left:70.6666259765625px;"> Tyk2 </div> <div id="el11_off" data-id="11" data-set="Tyk26" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off11" style="top:245.66667938232422px;left:70.6666259765625px;"> Tyk2</div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el12_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray12 pw-gray" style="top:236.66667938232422px;left:30.6666259765625px;"> </div> <div id="el12_off" data-id="12" data-set="Jak27" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off12" style="top:236.66667938232422px;left:30.6666259765625px;"> </div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el13_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray13 pw-gray" style="top:250.33334350585938px;left:12.6666259765625px;"> Jak2 </div> <div id="el13_off" data-id="13" data-set="Jak27" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off13" style="top:250.33334350585938px;left:12.6666259765625px;"> Jak2</div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el14_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray14 pw-gray" style="top:284.00001525878906px;left:10.6666259765625px;"> </div> <div id="el14_off" data-id="14" data-set="STAT18" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off14" style="top:284.00001525878906px;left:10.6666259765625px;"> </div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el15_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray15 pw-gray" style="top:303.00001525878906px;left:3.6666259765625px;"> STAT1 </div> <div id="el15_off" data-id="15" data-set="STAT18" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off15" style="top:303.00001525878906px;left:3.6666259765625px;"> STAT1</div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el16_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray16 pw-gray" style="top:331.6666793823242px;left:23.6666259765625px;"> </div> <div id="el16_off" data-id="16" data-set="STAT39" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off16" style="top:331.6666793823242px;left:23.6666259765625px;"> </div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el17_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray17 pw-gray" style="top:350.6666793823242px;left:16.6666259765625px;"> STAT3 </div> <div id="el17_off" data-id="17" data-set="STAT39" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off17" style="top:350.6666793823242px;left:16.6666259765625px;"> STAT3</div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el18_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray18 pw-gray" style="top:402.66668701171875px;left:42.6666259765625px;"> </div> <div id="el18_off" data-id="18" data-set="STAT410" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off18" style="top:402.66668701171875px;left:42.6666259765625px;"> </div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el19_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray19 pw-gray" style="top:430.66666412353516px;left:38.6666259765625px;"> STAT4 </div> <div id="el19_off" data-id="19" data-set="STAT410" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off19" style="top:430.66666412353516px;left:38.6666259765625px;"> STAT4</div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el20_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray20 pw-gray" style="top:316.3333511352539px;left:77.6666259765625px;"> </div> <div id="el20_off" data-id="20" data-set="STAT511" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off20" style="top:316.3333511352539px;left:77.6666259765625px;"> </div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT5a">STAT5a</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5a/b">STAT5a/b</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5b">STAT5b</a><br> </div> </div> <div id="el21_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray21 pw-gray" style="top:337.3333511352539px;left:72.6666259765625px;"> STAT5 </div> <div id="el21_off" data-id="21" data-set="STAT511" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off21" style="top:337.3333511352539px;left:72.6666259765625px;"> STAT5</div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT5a">STAT5a</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5a/b">STAT5a/b</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5b">STAT5b</a><br> </div> </div> <div id="el22_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray22 pw-gray" style="top:491.3333549499512px;left:18.6666259765625px;"> </div> <div id="el22_off" data-id="22" data-set="STAT4Dimer12" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off22" style="top:491.3333549499512px;left:18.6666259765625px;"> </div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el23_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray23 pw-gray" style="top:522.0000114440918px;left:11.6666259765625px;"> STAT4 Dimer </div> <div id="el23_off" data-id="23" data-set="STAT4Dimer12" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off23" style="top:522.0000114440918px;left:11.6666259765625px;"> STAT4 Dimer</div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el24_gry" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-gray24 pw-gray" style="top:765.0000305175781px;left:41.6666259765625px;"> </div> <div id="el24_off" data-id="24" data-set="STAT413" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-sprite el-off24" style="top:765.0000305175781px;left:41.6666259765625px;"> </div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el25_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray25 pw-gray" style="top:756.6666870117188px;left:48.6666259765625px;"> STAT4 </div> <div id="el25_off" data-id="25" data-set="STAT413" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off25" style="top:756.6666870117188px;left:48.6666259765625px;"> STAT4</div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el26_gry" class="il-12signaling_all il-12signaling_il-12 pw-label el-gray26 pw-gray" style="top:755.0000305175781px;left:112.6666259765625px;"> IFN-gamma </div> <div id="el26_off" data-id="26" data-set="IFN-gamma" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-12 pw-label el-off26" style="top:755.0000305175781px;left:112.6666259765625px;"> IFN-gamma</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IFN-gamma">IFN-gamma</a><br> </div> </div> <div id="el27_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray27 pw-gray" style="top:46.66666793823242px;left:139.6666259765625px;"> IL-23 </div> <div id="el27_off" data-id="27" data-set="IL-2315" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off27" style="top:46.66666793823242px;left:139.6666259765625px;"> IL-23</div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br><a href="https://www.rndsystems.com/search?common_name=IL-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el28_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray28 pw-gray" style="top:63.000003814697266px;left:141.6666259765625px;"> </div> <div id="el28_off" data-id="28" data-set="p1916" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off28" style="top:63.000003814697266px;left:141.6666259765625px;"> </div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br> </div> </div> <div id="el29_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray29 pw-gray" style="top:66.33333587646484px;left:122.6666259765625px;"> p19 </div> <div id="el29_off" data-id="29" data-set="p1916" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off29" style="top:66.33333587646484px;left:122.6666259765625px;"> p19</div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br> </div> </div> <div id="el30_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray30 pw-gray" style="top:60.333335876464844px;left:146.6666259765625px;"> </div> <div id="el30_off" data-id="30" data-set="p4017" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off30" style="top:60.333335876464844px;left:146.6666259765625px;"> </div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el31_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray31 pw-gray" style="top:69.00000381469727px;left:161.6666259765625px;"> p40 </div> <div id="el31_off" data-id="31" data-set="p4017" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off31" style="top:69.00000381469727px;left:161.6666259765625px;"> p40</div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-23 p40">IL-12/IL-23 p40</a><br> </div> </div> <div id="el32_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray32 pw-gray" style="top:100.33333969116211px;left:133.6666259765625px;"> </div> <div id="el32_off" data-id="32" data-set="IL-23R18" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off32" style="top:100.33333969116211px;left:133.6666259765625px;"> </div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23 R">IL-23 R</a><br> </div> </div> <div id="el33_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray33 pw-gray" style="top:131.6666717529297px;left:97.6666259765625px;"> IL-23 R </div> <div id="el33_off" data-id="33" data-set="IL-23R18" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off33" style="top:131.6666717529297px;left:97.6666259765625px;"> IL-23 R</div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23 R">IL-23 R</a><br> </div> </div> <div id="el34_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray34 pw-gray" style="top:114.00000762939453px;left:145.6666259765625px;"> </div> <div id="el34_off" data-id="34" data-set="IL-12Rbeta119" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off34" style="top:114.00000762939453px;left:145.6666259765625px;"> </div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 1">IL-12 R beta 1</a><br> </div> </div> <div id="el35_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray35 pw-gray" style="top:146.00000381469727px;left:162.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 1</div> </div> <div id="el35_off" data-id="35" data-set="IL-12Rbeta119" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off35" style="top:146.00000381469727px;left:162.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 1</div></div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 1">IL-12 R beta 1</a><br> </div> </div> <div id="el36_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray36 pw-gray" style="top:217.0000114440918px;left:130.6666259765625px;"> </div> <div id="el36_off" data-id="36" data-set="Jak220" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off36" style="top:217.0000114440918px;left:130.6666259765625px;"> </div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el37_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray37 pw-gray" style="top:229.6666717529297px;left:109.6666259765625px;"> Jak2 </div> <div id="el37_off" data-id="37" data-set="Jak220" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off37" style="top:229.6666717529297px;left:109.6666259765625px;"> Jak2</div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el38_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray38 pw-gray" style="top:211.6666717529297px;left:158.6666259765625px;"> </div> <div id="el38_off" data-id="38" data-set="Tyk221" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off38" style="top:211.6666717529297px;left:158.6666259765625px;"> </div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el39_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray39 pw-gray" style="top:220.3333282470703px;left:177.6666259765625px;"> Tyk2 </div> <div id="el39_off" data-id="39" data-set="Tyk221" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off39" style="top:220.3333282470703px;left:177.6666259765625px;"> Tyk2</div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el40_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray40 pw-gray" style="top:257.3333282470703px;left:111.6666259765625px;"> </div> <div id="el40_off" data-id="40" data-set="STAT122" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off40" style="top:257.3333282470703px;left:111.6666259765625px;"> </div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el41_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray41 pw-gray" style="top:277.00001525878906px;left:96.6666259765625px;"> STAT1 </div> <div id="el41_off" data-id="41" data-set="STAT122" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off41" style="top:277.00001525878906px;left:96.6666259765625px;"> STAT1</div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el42_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray42 pw-gray" style="top:309.3333282470703px;left:123.6666259765625px;"> </div> <div id="el42_off" data-id="42" data-set="STAT323" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off42" style="top:309.3333282470703px;left:123.6666259765625px;"> </div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el43_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray43 pw-gray" style="top:338.6666717529297px;left:116.6666259765625px;"> STAT3 </div> <div id="el43_off" data-id="43" data-set="STAT323" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off43" style="top:338.6666717529297px;left:116.6666259765625px;"> STAT3</div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el44_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray44 pw-gray" style="top:331.3333282470703px;left:167.6666259765625px;"> </div> <div id="el44_off" data-id="44" data-set="STAT424" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off44" style="top:331.3333282470703px;left:167.6666259765625px;"> </div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el45_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray45 pw-gray" style="top:355.3333282470703px;left:164.6666259765625px;"> STAT4 </div> <div id="el45_off" data-id="45" data-set="STAT424" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off45" style="top:355.3333282470703px;left:164.6666259765625px;"> STAT4</div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el46_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray46 pw-gray" style="top:245.3333282470703px;left:185.6666259765625px;"> </div> <div id="el46_off" data-id="46" data-set="STAT525" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off46" style="top:245.3333282470703px;left:185.6666259765625px;"> </div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT5a">STAT5a</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5a/b">STAT5a/b</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5b">STAT5b</a><br> </div> </div> <div id="el47_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray47 pw-gray" style="top:264.00001525878906px;left:178.6666259765625px;"> STAT5 </div> <div id="el47_off" data-id="47" data-set="STAT525" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off47" style="top:264.00001525878906px;left:178.6666259765625px;"> STAT5</div> <div id="el47_ct" class="pw-tooltip" data-id="47"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT5a">STAT5a</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5a/b">STAT5a/b</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5b">STAT5b</a><br> </div> </div> <div id="el48_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray48 pw-gray" style="top:451.0000203847885px;left:93.6666259765625px;"> </div> <div id="el48_off" data-id="48" data-set="STAT3Dimer26" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off48" style="top:451.0000203847885px;left:93.6666259765625px;"> </div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el49_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray49 pw-gray" style="top:478.66667687892914px;left:84.6666259765625px;"> STAT3 Dimer </div> <div id="el49_off" data-id="49" data-set="STAT3Dimer26" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off49" style="top:478.66667687892914px;left:84.6666259765625px;"> STAT3 Dimer</div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el50_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray50 pw-gray" style="top:413.66667687892914px;left:160.6666259765625px;"> </div> <div id="el50_off" data-id="50" data-set="STAT4Dimer27" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off50" style="top:413.66667687892914px;left:160.6666259765625px;"> </div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el51_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray51 pw-gray" style="top:437.3333435058594px;left:146.6666259765625px;"> STAT4 Dimer </div> <div id="el51_off" data-id="51" data-set="STAT4Dimer27" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off51" style="top:437.3333435058594px;left:146.6666259765625px;"> STAT4 Dimer</div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el52_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray52 pw-gray" style="top:690.3333435058594px;left:110.6666259765625px;"> </div> <div id="el52_off" data-id="52" data-set="STAT328" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off52" style="top:690.3333435058594px;left:110.6666259765625px;"> </div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el53_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray53 pw-gray" style="top:681.0000305175781px;left:118.6666259765625px;"> STAT3 </div> <div id="el53_off" data-id="53" data-set="STAT328" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off53" style="top:681.0000305175781px;left:118.6666259765625px;"> STAT3</div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el54_gry" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-gray54 pw-gray" style="top:704.0000305175781px;left:262.6666259765625px;"> </div> <div id="el54_off" data-id="54" data-set="STAT429" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-sprite el-off54" style="top:704.0000305175781px;left:262.6666259765625px;"> </div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el55_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray55 pw-gray" style="top:696.6666870117188px;left:261.6666259765625px;"> STAT4 </div> <div id="el55_off" data-id="55" data-set="STAT429" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off55" style="top:696.6666870117188px;left:261.6666259765625px;"> STAT4</div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el56_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray56 pw-gray" style="top:657.0000152587891px;left:179.6666259765625px;"> IL-21 </div> <div id="el56_off" data-id="56" data-set="IL-21" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off56" style="top:657.0000152587891px;left:179.6666259765625px;"> IL-21</div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-21">IL-21</a><br> </div> </div> <div id="el57_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray57 pw-gray" style="top:671.3333435058594px;left:179.6666259765625px;"> ROR gamma t </div> <div id="el57_off" data-id="57" data-set="RORgammat" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off57" style="top:671.3333435058594px;left:179.6666259765625px;"> ROR gamma t</div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=ROR gamma t/RORC2/NR1F3">ROR gamma t</a><br> </div> </div> <div id="el58_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray58 pw-gray" style="top:685.6666870117188px;left:179.6666259765625px;"> IL-23 R </div> <div id="el58_off" data-id="58" data-set="IL-23R" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off58" style="top:685.6666870117188px;left:179.6666259765625px;"> IL-23 R</div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23 R">IL-23 R</a><br> </div> </div> <div id="el59_gry" class="il-12signaling_all il-12signaling_il-23 pw-label el-gray59 pw-gray" style="top:701.0000305175781px;left:179.6666259765625px;"> IL-17A </div> <div id="el59_off" data-id="59" data-set="IL-17A" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-23 pw-label el-off59" style="top:701.0000305175781px;left:179.6666259765625px;"> IL-17A</div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-17/IL-17A">IL-17</a><br><a href="https://www.rndsystems.com/search?common_name=IL-17A/F Heterodimer">IL-17A/F Heterodimer</a><br> </div> </div> <div id="el60_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray60 pw-gray" style="top:41.66666793823242px;left:253.6666259765625px;"> IL-27 </div> <div id="el60_off" data-id="60" data-set="IL-2734" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off60" style="top:41.66666793823242px;left:253.6666259765625px;"> IL-27</div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27">IL-27</a><br><a href="https://www.rndsystems.com/search?common_name=IL-27 p28/IL-30">IL-27 p28</a><br><a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el61_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray61 pw-gray" style="top:58.000003814697266px;left:260.6666259765625px;"> </div> <div id="el61_off" data-id="61" data-set="p2835" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off61" style="top:58.000003814697266px;left:260.6666259765625px;"> </div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27 p28/IL-30">IL-27 p28</a><br> </div> </div> <div id="el62_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray62 pw-gray" style="top:58.33333206176758px;left:240.6666259765625px;"> p28 </div> <div id="el62_off" data-id="62" data-set="p2835" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off62" style="top:58.33333206176758px;left:240.6666259765625px;"> p28</div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27 p28/IL-30">IL-27 p28</a><br> </div> </div> <div id="el63_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray63 pw-gray" style="top:60.000003814697266px;left:264.6666259765625px;"> </div> <div id="el63_off" data-id="63" data-set="EBI336" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off63" style="top:60.000003814697266px;left:264.6666259765625px;"> </div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el64_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray64 pw-gray" style="top:66.00000381469727px;left:277.6666259765625px;"> EBI3 </div> <div id="el64_off" data-id="64" data-set="EBI336" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off64" style="top:66.00000381469727px;left:277.6666259765625px;"> EBI3</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el65_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray65 pw-gray" style="top:100.33333206176758px;left:253.6666259765625px;"> </div> <div id="el65_off" data-id="65" data-set="IL-27RalphaWSX-137" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off65" style="top:100.33333206176758px;left:253.6666259765625px;"> </div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27 R alpha/WSX-1/TCCR">IL-27 R alpha</a><br> </div> </div> <div id="el66_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray66 pw-gray" style="top:105.33333206176758px;left:214.6666259765625px;"> <div style="text-align: center;">IL-27 R<br>alpha/<br>WSX-1</div> </div> <div id="el66_off" data-id="66" data-set="IL-27RalphaWSX-137" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off66" style="top:105.33333206176758px;left:214.6666259765625px;"> <div style="text-align: center;">IL-27 R<br>alpha/<br>WSX-1</div></div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27 R alpha/WSX-1/TCCR">IL-27 R alpha</a><br> </div> </div> <div id="el67_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray67 pw-gray" style="top:85.6666693687439px;left:266.6666259765625px;"> </div> <div id="el67_off" data-id="67" data-set="gp13038" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off67" style="top:85.6666693687439px;left:266.6666259765625px;"> </div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el68_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray68 pw-gray" style="top:104.6666692495346px;left:286.6666259765625px;"> gp130 </div> <div id="el68_off" data-id="68" data-set="gp13038" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off68" style="top:104.6666692495346px;left:286.6666259765625px;"> gp130</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el69_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray69 pw-gray" style="top:196.67708206176758px;left:243.6666259765625px;"> </div> <div id="el69_off" data-id="69" data-set="Jak139" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off69" style="top:196.67708206176758px;left:243.6666259765625px;"> </div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el70_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray70 pw-gray" style="top:203.33333587646484px;left:220.6666259765625px;"> Jak1 </div> <div id="el70_off" data-id="70" data-set="Jak139" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off70" style="top:203.33333587646484px;left:220.6666259765625px;"> Jak1</div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el71_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray71 pw-gray" style="top:201.33333587646484px;left:276.6666259765625px;"> </div> <div id="el71_off" data-id="71" data-set="Jak140" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off71" style="top:201.33333587646484px;left:276.6666259765625px;"> </div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el72_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray72 pw-gray" style="top:202.0000114440918px;left:296.6666259765625px;"> Jak1 </div> <div id="el72_off" data-id="72" data-set="Jak140" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off72" style="top:202.0000114440918px;left:296.6666259765625px;"> Jak1</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el73_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray73 pw-gray" style="top:205.00000762939453px;left:270.6666259765625px;"> </div> <div id="el73_off" data-id="73" data-set="Jak241" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off73" style="top:205.00000762939453px;left:270.6666259765625px;"> </div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el74_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray74 pw-gray" style="top:214.6666717529297px;left:289.6666259765625px;"> Jak2 </div> <div id="el74_off" data-id="74" data-set="Jak241" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off74" style="top:214.6666717529297px;left:289.6666259765625px;"> Jak2</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el75_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray75 pw-gray" style="top:208.66666793823242px;left:259.6666259765625px;"> </div> <div id="el75_off" data-id="75" data-set="Tyk242" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off75" style="top:208.66666793823242px;left:259.6666259765625px;"> </div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el76_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray76 pw-gray" style="top:222.3333396911621px;left:236.6666259765625px;"> Tyk2 </div> <div id="el76_off" data-id="76" data-set="Tyk242" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off76" style="top:222.3333396911621px;left:236.6666259765625px;"> Tyk2</div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el77_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray77 pw-gray" style="top:285.3333282470703px;left:220.6666259765625px;"> </div> <div id="el77_off" data-id="77" data-set="STAT143" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off77" style="top:285.3333282470703px;left:220.6666259765625px;"> </div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el78_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray78 pw-gray" style="top:314.00001525878906px;left:218.6666259765625px;"> STAT1 </div> <div id="el78_off" data-id="78" data-set="STAT143" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off78" style="top:314.00001525878906px;left:218.6666259765625px;"> STAT1</div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el79_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray79 pw-gray" style="top:310.6666717529297px;left:295.6666259765625px;"> </div> <div id="el79_off" data-id="79" data-set="STAT344" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off79" style="top:310.6666717529297px;left:295.6666259765625px;"> </div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el80_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray80 pw-gray" style="top:332.6666717529297px;left:290.6666259765625px;"> STAT3 </div> <div id="el80_off" data-id="80" data-set="STAT344" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off80" style="top:332.6666717529297px;left:290.6666259765625px;"> STAT3</div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el81_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray81 pw-gray" style="top:261.3333282470703px;left:293.6666259765625px;"> </div> <div id="el81_off" data-id="81" data-set="STAT445" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off81" style="top:261.3333282470703px;left:293.6666259765625px;"> </div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el82_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray82 pw-gray" style="top:282.3333282470703px;left:288.6666259765625px;"> STAT4 </div> <div id="el82_off" data-id="82" data-set="STAT445" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off82" style="top:282.3333282470703px;left:288.6666259765625px;"> STAT4</div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el83_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray83 pw-gray" style="top:233.00001525878906px;left:313.6666259765625px;"> </div> <div id="el83_off" data-id="83" data-set="STAT546" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off83" style="top:233.00001525878906px;left:313.6666259765625px;"> </div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT5a">STAT5a</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5a/b">STAT5a/b</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5b">STAT5b</a><br> </div> </div> <div id="el84_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray84 pw-gray" style="top:251.00001525878906px;left:323.6666259765625px;"> STAT5 </div> <div id="el84_off" data-id="84" data-set="STAT546" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off84" style="top:251.00001525878906px;left:323.6666259765625px;"> STAT5</div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT5a">STAT5a</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5a/b">STAT5a/b</a><br><a href="https://www.rndsystems.com/search?common_name=STAT5b">STAT5b</a><br> </div> </div> <div id="el85_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray85 pw-gray" style="top:444.0000203847885px;left:230.6666259765625px;"> </div> <div id="el85_off" data-id="85" data-set="STAT1Dimer47" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off85" style="top:444.0000203847885px;left:230.6666259765625px;"> </div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el86_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray86 pw-gray" style="top:471.66667687892914px;left:215.6666259765625px;"> STAT1 Dimer </div> <div id="el86_off" data-id="86" data-set="STAT1Dimer47" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off86" style="top:471.66667687892914px;left:215.6666259765625px;"> STAT1 Dimer</div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el87_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray87 pw-gray" style="top:370.33333337306976px;left:265.6666259765625px;"> </div> <div id="el87_off" data-id="87" data-set="STAT1-STAT3Heterodimer48" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off87" style="top:370.33333337306976px;left:265.6666259765625px;"> </div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br><a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el88_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray88 pw-gray" style="top:393.33333337306976px;left:246.6666259765625px;"> <div style="text-align: center;">STAT1-STAT3<br>Heterodimer</div> </div> <div id="el88_off" data-id="88" data-set="STAT1-STAT3Heterodimer48" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off88" style="top:393.33333337306976px;left:246.6666259765625px;"> <div style="text-align: center;">STAT1-STAT3<br>Heterodimer</div></div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br><a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el89_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray89 pw-gray" style="top:466.0000228881836px;left:321.6666259765625px;"> </div> <div id="el89_off" data-id="89" data-set="STAT3Dimer49" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off89" style="top:466.0000228881836px;left:321.6666259765625px;"> </div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el90_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray90 pw-gray" style="top:488.0000228881836px;left:301.6666259765625px;"> STAT3 Dimer </div> <div id="el90_off" data-id="90" data-set="STAT3Dimer49" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off90" style="top:488.0000228881836px;left:301.6666259765625px;"> STAT3 Dimer</div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el91_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray91 pw-gray" style="top:776.0000305175781px;left:304.6666259765625px;"> </div> <div id="el91_off" data-id="91" data-set="STAT150" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off91" style="top:776.0000305175781px;left:304.6666259765625px;"> </div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el92_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray92 pw-gray" style="top:766.6666870117188px;left:310.6666259765625px;"> STAT1 </div> <div id="el92_off" data-id="92" data-set="STAT150" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off92" style="top:766.6666870117188px;left:310.6666259765625px;"> STAT1</div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el93_gry" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-gray93 pw-gray" style="top:787.3333435058594px;left:433.6666259765625px;"> </div> <div id="el93_off" data-id="93" data-set="STAT351" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-sprite el-off93" style="top:787.3333435058594px;left:433.6666259765625px;"> </div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el94_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray94 pw-gray" style="top:779.3333435058594px;left:428.6666259765625px;"> STAT3 </div> <div id="el94_off" data-id="94" data-set="STAT351" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off94" style="top:779.3333435058594px;left:428.6666259765625px;"> STAT3</div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el95_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray95 pw-gray" style="top:761.6666870117188px;left:370.6666259765625px;"> T-bet </div> <div id="el95_off" data-id="95" data-set="T-bet" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off95" style="top:761.6666870117188px;left:370.6666259765625px;"> T-bet</div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=T-bet/TBX21">T-bet</a><br> </div> </div> <div id="el96_gry" class="il-12signaling_all il-12signaling_il-27 pw-label el-gray96 pw-gray" style="top:776.6666870117188px;left:370.6666259765625px;"> GATA-3 </div> <div id="el96_off" data-id="96" data-set="GATA-3" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-27 pw-label el-off96" style="top:776.6666870117188px;left:370.6666259765625px;"> GATA-3</div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=GATA-3">GATA-3</a><br> </div> </div> <div id="el97_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray97 pw-gray" style="top:25.333328247070312px;left:373.6666259765625px;"> IL-35 </div> <div id="el97_off" data-id="97" data-set="IL-3554" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off97" style="top:25.333328247070312px;left:373.6666259765625px;"> IL-35</div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br><a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el98_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray98 pw-gray" style="top:38.66667175292969px;left:377.6666259765625px;"> </div> <div id="el98_off" data-id="98" data-set="p3555" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off98" style="top:38.66667175292969px;left:377.6666259765625px;"> </div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br> </div> </div> <div id="el99_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray99 pw-gray" style="top:42px;left:358.6666259765625px;"> p35 </div> <div id="el99_off" data-id="99" data-set="p3555" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off99" style="top:42px;left:358.6666259765625px;"> p35</div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br> </div> </div> <div id="el100_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray100 pw-gray" style="top:42.66667175292969px;left:383.6666259765625px;"> </div> <div id="el100_off" data-id="100" data-set="EBI356" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off100" style="top:42.66667175292969px;left:383.6666259765625px;"> </div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el101_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray101 pw-gray" style="top:55.66667175292969px;left:396.6666259765625px;"> EBI3 </div> <div id="el101_off" data-id="101" data-set="EBI356" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off101" style="top:55.66667175292969px;left:396.6666259765625px;"> EBI3</div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el102_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray102 pw-gray" style="top:84px;left:381.6666259765625px;"> </div> <div id="el102_off" data-id="102" data-set="gp13057" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off102" style="top:84px;left:381.6666259765625px;"> </div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el103_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray103 pw-gray" style="top:118px;left:399.6666259765625px;"> gp130 </div> <div id="el103_off" data-id="103" data-set="gp13057" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off103" style="top:118px;left:399.6666259765625px;"> gp130</div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el104_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray104 pw-gray" style="top:85.33333587646484px;left:368.6666259765625px;"> </div> <div id="el104_off" data-id="104" data-set="IL-12Rbeta258" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off104" style="top:85.33333587646484px;left:368.6666259765625px;"> </div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 2">IL-12 R beta 2</a><br> </div> </div> <div id="el105_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray105 pw-gray" style="top:124.33332824707031px;left:330.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 2</div> </div> <div id="el105_off" data-id="105" data-set="IL-12Rbeta258" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off105" style="top:124.33332824707031px;left:330.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 2</div></div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 2">IL-12 R beta 2</a><br> </div> </div> <div id="el106_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray106 pw-gray" style="top:197.33333587646484px;left:389.6666259765625px;"> </div> <div id="el106_off" data-id="106" data-set="Jak159" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off106" style="top:197.33333587646484px;left:389.6666259765625px;"> </div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el107_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray107 pw-gray" style="top:206.00000512599945px;left:407.6666259765625px;"> Jak1 </div> <div id="el107_off" data-id="107" data-set="Jak159" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off107" style="top:206.00000512599945px;left:407.6666259765625px;"> Jak1</div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el108_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray108 pw-gray" style="top:205.00000512599945px;left:383.6666259765625px;"> </div> <div id="el108_off" data-id="108" data-set="Jak260" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off108" style="top:205.00000512599945px;left:383.6666259765625px;"> </div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el109_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray109 pw-gray" style="top:220.6666774749756px;left:395.6666259765625px;"> Jak2 </div> <div id="el109_off" data-id="109" data-set="Jak260" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off109" style="top:220.6666774749756px;left:395.6666259765625px;"> Jak2</div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el110_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray110 pw-gray" style="top:206.67708206176758px;left:375.6666259765625px;"> </div> <div id="el110_off" data-id="110" data-set="Tyk261" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off110" style="top:206.67708206176758px;left:375.6666259765625px;"> </div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el111_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray111 pw-gray" style="top:219.33333337306976px;left:353.6666259765625px;"> Tyk2 </div> <div id="el111_off" data-id="111" data-set="Tyk261" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off111" style="top:219.33333337306976px;left:353.6666259765625px;"> Tyk2</div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el112_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray112 pw-gray" style="top:195.33333587646484px;left:359.6666259765625px;"> </div> <div id="el112_off" data-id="112" data-set="Jak262" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off112" style="top:195.33333587646484px;left:359.6666259765625px;"> </div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el113_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray113 pw-gray" style="top:197.00000762939453px;left:334.6666259765625px;"> Jak2 </div> <div id="el113_off" data-id="113" data-set="Jak262" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off113" style="top:197.00000762939453px;left:334.6666259765625px;"> Jak2</div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el114_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray114 pw-gray" style="top:271.0000100135803px;left:386.6666259765625px;"> </div> <div id="el114_off" data-id="114" data-set="STAT363" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off114" style="top:271.0000100135803px;left:386.6666259765625px;"> </div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el115_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray115 pw-gray" style="top:291.6666717529297px;left:381.6666259765625px;"> STAT3 </div> <div id="el115_off" data-id="115" data-set="STAT363" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off115" style="top:291.6666717529297px;left:381.6666259765625px;"> STAT3</div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el116_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray116 pw-gray" style="top:311.6666717529297px;left:348.6666259765625px;"> </div> <div id="el116_off" data-id="116" data-set="STAT164" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off116" style="top:311.6666717529297px;left:348.6666259765625px;"> </div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el117_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray117 pw-gray" style="top:340.3333549499512px;left:348.6666259765625px;"> STAT1 </div> <div id="el117_off" data-id="117" data-set="STAT164" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off117" style="top:340.3333549499512px;left:348.6666259765625px;"> STAT1</div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el118_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray118 pw-gray" style="top:308.3333339691162px;left:422.6666259765625px;"> </div> <div id="el118_off" data-id="118" data-set="STAT465" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off118" style="top:308.3333339691162px;left:422.6666259765625px;"> </div> <div id="el118_ct" class="pw-tooltip" data-id="118"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el119_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray119 pw-gray" style="top:338.00002098083496px;left:422.6666259765625px;"> STAT4 </div> <div id="el119_off" data-id="119" data-set="STAT465" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off119" style="top:338.00002098083496px;left:422.6666259765625px;"> STAT4</div> <div id="el119_ct" class="pw-tooltip" data-id="119"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el120_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray120 pw-gray" style="top:408.00002098083496px;left:384.6666259765625px;"> </div> <div id="el120_off" data-id="120" data-set="STAT1-STAT4Heterodimer66" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off120" style="top:408.00002098083496px;left:384.6666259765625px;"> </div> <div id="el120_ct" class="pw-tooltip" data-id="120"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br><a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el121_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray121 pw-gray" style="top:436.6666774749756px;left:370.6666259765625px;"> <div style="text-align: center;">STAT1-STAT4<br>Heterodimer</div> </div> <div id="el121_off" data-id="121" data-set="STAT1-STAT4Heterodimer66" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off121" style="top:436.6666774749756px;left:370.6666259765625px;"> <div style="text-align: center;">STAT1-STAT4<br>Heterodimer</div></div> <div id="el121_ct" class="pw-tooltip" data-id="121"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br><a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el122_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray122 pw-gray" style="top:689.6666870117188px;left:457.6666259765625px;"> </div> <div id="el122_off" data-id="122" data-set="STAT1-STAT467" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off122" style="top:689.6666870117188px;left:457.6666259765625px;"> </div> <div id="el122_ct" class="pw-tooltip" data-id="122"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br><a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el123_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray123 pw-gray" style="top:680.3333435058594px;left:422.6666259765625px;"> STAT1-STAT4 </div> <div id="el123_off" data-id="123" data-set="STAT1-STAT467" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off123" style="top:680.3333435058594px;left:422.6666259765625px;"> STAT1-STAT4</div> <div id="el123_ct" class="pw-tooltip" data-id="123"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br><a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el124_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray124 pw-gray" style="top:678.6666870117188px;left:524.6666259765625px;"> IL-12 alpha/p35 </div> <div id="el124_off" data-id="124" data-set="IL-12alphap35" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off124" style="top:678.6666870117188px;left:524.6666259765625px;"> IL-12 alpha/p35</div> <div id="el124_ct" class="pw-tooltip" data-id="124"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12/IL-35 p35">IL-12/IL-35 p35</a><br> </div> </div> <div id="el125_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray125 pw-gray" style="top:691.0000305175781px;left:524.6666259765625px;"> EBI3 </div> <div id="el125_off" data-id="125" data-set="EBI3" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off125" style="top:691.0000305175781px;left:524.6666259765625px;"> EBI3</div> <div id="el125_ct" class="pw-tooltip" data-id="125"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el126_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray126 pw-gray" style="top:83.33333587646484px;left:461.6666259765625px;"> </div> <div id="el126_off" data-id="126" data-set="gp13070" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off126" style="top:83.33333587646484px;left:461.6666259765625px;"> </div> <div id="el126_ct" class="pw-tooltip" data-id="126"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el127_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray127 pw-gray" style="top:150.66667687892914px;left:430.6666259765625px;"> gp130 </div> <div id="el127_off" data-id="127" data-set="gp13070" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off127" style="top:150.66667687892914px;left:430.6666259765625px;"> gp130</div> <div id="el127_ct" class="pw-tooltip" data-id="127"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el128_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray128 pw-gray" style="top:87.00000190734863px;left:476.6666259765625px;"> </div> <div id="el128_off" data-id="128" data-set="gp13071" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off128" style="top:87.00000190734863px;left:476.6666259765625px;"> </div> <div id="el128_ct" class="pw-tooltip" data-id="128"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el129_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray129 pw-gray" style="top:149.00000381469727px;left:495.6666259765625px;"> gp130 </div> <div id="el129_off" data-id="129" data-set="gp13071" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off129" style="top:149.00000381469727px;left:495.6666259765625px;"> gp130</div> <div id="el129_ct" class="pw-tooltip" data-id="129"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=gp130">gp130</a><br> </div> </div> <div id="el130_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray130 pw-gray" style="top:194.00000762939453px;left:454.6666259765625px;"> </div> <div id="el130_off" data-id="130" data-set="Jak172" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off130" style="top:194.00000762939453px;left:454.6666259765625px;"> </div> <div id="el130_ct" class="pw-tooltip" data-id="130"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el131_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray131 pw-gray" style="top:193.66667556762695px;left:429.6666259765625px;"> Jak1 </div> <div id="el131_off" data-id="131" data-set="Jak172" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off131" style="top:193.66667556762695px;left:429.6666259765625px;"> Jak1</div> <div id="el131_ct" class="pw-tooltip" data-id="131"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el132_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray132 pw-gray" style="top:204.66667938232422px;left:453.6666259765625px;"> </div> <div id="el132_off" data-id="132" data-set="Jak273" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off132" style="top:204.66667938232422px;left:453.6666259765625px;"> </div> <div id="el132_ct" class="pw-tooltip" data-id="132"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el133_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray133 pw-gray" style="top:214.33334350585938px;left:432.6666259765625px;"> Jak2 </div> <div id="el133_off" data-id="133" data-set="Jak273" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off133" style="top:214.33334350585938px;left:432.6666259765625px;"> Jak2</div> <div id="el133_ct" class="pw-tooltip" data-id="133"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el134_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray134 pw-gray" style="top:208.33334350585938px;left:462.6666259765625px;"> </div> <div id="el134_off" data-id="134" data-set="Tyk274" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off134" style="top:208.33334350585938px;left:462.6666259765625px;"> </div> <div id="el134_ct" class="pw-tooltip" data-id="134"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el135_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray135 pw-gray" style="top:228.00000762939453px;left:449.6666259765625px;"> Tyk2 </div> <div id="el135_off" data-id="135" data-set="Tyk274" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off135" style="top:228.00000762939453px;left:449.6666259765625px;"> Tyk2</div> <div id="el135_ct" class="pw-tooltip" data-id="135"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el136_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray136 pw-gray" style="top:194.00000762939453px;left:485.6666259765625px;"> </div> <div id="el136_off" data-id="136" data-set="Jak175" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off136" style="top:194.00000762939453px;left:485.6666259765625px;"> </div> <div id="el136_ct" class="pw-tooltip" data-id="136"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el137_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray137 pw-gray" style="top:190.6666717529297px;left:503.6666259765625px;"> Jak1 </div> <div id="el137_off" data-id="137" data-set="Jak175" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off137" style="top:190.6666717529297px;left:503.6666259765625px;"> Jak1</div> <div id="el137_ct" class="pw-tooltip" data-id="137"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el138_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray138 pw-gray" style="top:205.6666717529297px;left:486.6666259765625px;"> </div> <div id="el138_off" data-id="138" data-set="Jak276" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off138" style="top:205.6666717529297px;left:486.6666259765625px;"> </div> <div id="el138_ct" class="pw-tooltip" data-id="138"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el139_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray139 pw-gray" style="top:203.6666717529297px;left:501.6666259765625px;"> Jak2 </div> <div id="el139_off" data-id="139" data-set="Jak276" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off139" style="top:203.6666717529297px;left:501.6666259765625px;"> Jak2</div> <div id="el139_ct" class="pw-tooltip" data-id="139"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el140_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray140 pw-gray" style="top:207.6666717529297px;left:475.6666259765625px;"> </div> <div id="el140_off" data-id="140" data-set="Tyk277" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off140" style="top:207.6666717529297px;left:475.6666259765625px;"> </div> <div id="el140_ct" class="pw-tooltip" data-id="140"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el141_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray141 pw-gray" style="top:224.3333282470703px;left:491.6666259765625px;"> Tyk2 </div> <div id="el141_off" data-id="141" data-set="Tyk277" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off141" style="top:224.3333282470703px;left:491.6666259765625px;"> Tyk2</div> <div id="el141_ct" class="pw-tooltip" data-id="141"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Tyk2">Tyk2</a><br> </div> </div> <div id="el142_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray142 pw-gray" style="top:266.6666717529297px;left:468.6666259765625px;"> </div> <div id="el142_off" data-id="142" data-set="STAT178" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off142" style="top:266.6666717529297px;left:468.6666259765625px;"> </div> <div id="el142_ct" class="pw-tooltip" data-id="142"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a 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style="top:114px;left:501.6666259765625px;"> <div style="text-align: center;">IL-12 R<br>beta 2</div></div> <div id="el147_ct" class="pw-tooltip" data-id="147"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 2">IL-12 R beta 2</a><br> </div> </div> <div id="el148_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray148 pw-gray" style="top:96.33333396911621px;left:553.6666259765625px;"> </div> <div id="el148_off" data-id="148" data-set="IL-12Rbeta281" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off148" style="top:96.33333396911621px;left:553.6666259765625px;"> </div> <div id="el148_ct" class="pw-tooltip" data-id="148"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-12 R beta 2">IL-12 R beta 2</a><br> </div> 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</div> <div id="el152_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray152 pw-gray" style="top:207.3333339691162px;left:562.6666259765625px;"> </div> <div id="el152_off" data-id="152" data-set="Jak283" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off152" style="top:207.3333339691162px;left:562.6666259765625px;"> </div> <div id="el152_ct" class="pw-tooltip" data-id="152"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el153_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray153 pw-gray" style="top:220.0000114440918px;left:562.6666259765625px;"> Jak2 </div> <div id="el153_off" data-id="153" data-set="Jak283" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off153" style="top:220.0000114440918px;left:562.6666259765625px;"> Jak2</div> <div id="el153_ct" class="pw-tooltip" data-id="153"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el154_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray154 pw-gray" style="top:270.3333435058594px;left:520.6666259765625px;"> </div> <div id="el154_off" data-id="154" data-set="STAT484" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off154" style="top:270.3333435058594px;left:520.6666259765625px;"> </div> <div id="el154_ct" class="pw-tooltip" data-id="154"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el155_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray155 pw-gray" style="top:291.6666793823242px;left:517.6666259765625px;"> STAT4 </div> <div id="el155_off" data-id="155" data-set="STAT484" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off155" style="top:291.6666793823242px;left:517.6666259765625px;"> STAT4</div> <div id="el155_ct" class="pw-tooltip" data-id="155"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT4">STAT4</a><br> </div> </div> <div id="el156_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray156 pw-gray" style="top:398.3333435058594px;left:530.6666259765625px;"> </div> <div id="el156_off" data-id="156" data-set="STAT4Dimer85" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off156" style="top:398.3333435058594px;left:530.6666259765625px;"> </div> <div id="el156_ct" class="pw-tooltip" data-id="156"> <div 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el-gray161 pw-gray" style="top:237.3333339691162px;left:633.6666564941406px;"> Jak1 </div> <div id="el161_off" data-id="161" data-set="Jak187" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off161" style="top:237.3333339691162px;left:633.6666564941406px;"> Jak1</div> <div id="el161_ct" class="pw-tooltip" data-id="161"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el162_gry" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-gray162 pw-gray" style="top:224.33333587646484px;left:606.6666564941406px;"> </div> <div id="el162_off" data-id="162" data-set="Jak288" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off162" style="top:224.33333587646484px;left:606.6666564941406px;"> </div> <div id="el162_ct" class="pw-tooltip" data-id="162"> <div 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data-set="STAT189" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-sprite el-off164" style="top:268.3333435058594px;left:576.6666564941406px;"> </div> <div id="el164_ct" class="pw-tooltip" data-id="164"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el165_gry" class="il-12signaling_all il-12signaling_il-35 pw-label el-gray165 pw-gray" style="top:297px;left:574.6666564941406px;"> STAT1 </div> <div id="el165_off" data-id="165" data-set="STAT189" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-35 pw-label el-off165" style="top:297px;left:574.6666564941406px;"> STAT1</div> <div id="el165_ct" class="pw-tooltip" data-id="165"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a 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il-12signaling_il-35 pw-label el-off167" style="top:357.66668701171875px;left:577.6666564941406px;"> STAT3</div> <div id="el167_ct" class="pw-tooltip" data-id="167"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el168_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray168 pw-gray" style="top:55.333335876464844px;left:687.6666564941406px;"> IL-39 </div> <div id="el168_off" data-id="168" data-set="IL-3991" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off168" style="top:55.333335876464844px;left:687.6666564941406px;"> IL-39</div> <div id="el168_ct" class="pw-tooltip" data-id="168"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/il-39-il-23p19-ebi3">IL-39</a><br><a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br><a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el169_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray169 pw-gray" style="top:72.66667175292969px;left:687.6666564941406px;"> </div> <div id="el169_off" data-id="169" data-set="p1992" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off169" style="top:72.66667175292969px;left:687.6666564941406px;"> </div> <div id="el169_ct" class="pw-tooltip" data-id="169"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br> </div> </div> <div id="el170_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray170 pw-gray" style="top:78px;left:666.6666564941406px;"> p19 </div> <div id="el170_off" data-id="170" data-set="p1992" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off170" style="top:78px;left:666.6666564941406px;"> p19</div> <div id="el170_ct" class="pw-tooltip" data-id="170"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br> </div> </div> <div id="el171_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray171 pw-gray" style="top:71.66667175292969px;left:692.6666564941406px;"> </div> <div id="el171_off" data-id="171" data-set="EBI393" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off171" style="top:71.66667175292969px;left:692.6666564941406px;"> </div> <div id="el171_ct" class="pw-tooltip" data-id="171"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a 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pw-label el-gray178 pw-gray" style="top:243.33333587646484px;left:723.6666564941406px;"> Jak1 </div> <div id="el178_off" data-id="178" data-set="Jak196" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off178" style="top:243.33333587646484px;left:723.6666564941406px;"> Jak1</div> <div id="el178_ct" class="pw-tooltip" data-id="178"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak1">Jak1</a><br> </div> </div> <div id="el179_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray179 pw-gray" style="top:247.33334350585938px;left:702.6666564941406px;"> </div> <div id="el179_off" data-id="179" data-set="Jak297" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off179" style="top:247.33334350585938px;left:702.6666564941406px;"> </div> <div id="el179_ct" class="pw-tooltip" data-id="179"> <div 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<div id="el184_ct" class="pw-tooltip" data-id="184"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Jak2">Jak2</a><br> </div> </div> <div id="el185_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray185 pw-gray" style="top:309.3333435058594px;left:641.6666564941406px;"> </div> <div id="el185_off" data-id="185" data-set="STAT1100" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off185" style="top:309.3333435058594px;left:641.6666564941406px;"> </div> <div id="el185_ct" class="pw-tooltip" data-id="185"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el186_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray186 pw-gray" style="top:329.6667022705078px;left:638.666748046875px;"> STAT1 </div> <div id="el186_off" data-id="186" data-set="STAT1100" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off186" style="top:329.6667022705078px;left:638.666748046875px;"> STAT1</div> <div id="el186_ct" class="pw-tooltip" data-id="186"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el187_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray187 pw-gray" style="top:384.33333337306976px;left:620.666748046875px;"> </div> <div id="el187_off" data-id="187" data-set="STAT1Dimer101" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off187" style="top:384.33333337306976px;left:620.666748046875px;"> </div> <div id="el187_ct" class="pw-tooltip" data-id="187"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el188_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray188 pw-gray" style="top:414.33333337306976px;left:613.666748046875px;"> STAT1 Dimer </div> <div id="el188_off" data-id="188" data-set="STAT1Dimer101" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off188" style="top:414.33333337306976px;left:613.666748046875px;"> STAT1 Dimer</div> <div id="el188_ct" class="pw-tooltip" data-id="188"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el189_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray189 pw-gray" style="top:770.6666870117188px;left:581.666748046875px;"> </div> <div id="el189_off" data-id="189" data-set="STAT1102" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off189" style="top:770.6666870117188px;left:581.666748046875px;"> </div> <div id="el189_ct" class="pw-tooltip" data-id="189"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el190_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray190 pw-gray" style="top:759.0000305175781px;left:581.666748046875px;"> STAT1 </div> <div id="el190_off" data-id="190" data-set="STAT1102" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off190" style="top:759.0000305175781px;left:581.666748046875px;"> STAT1 </div> <div id="el190_ct" class="pw-tooltip" data-id="190"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT1">STAT1</a><br> </div> </div> <div id="el191_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray191 pw-gray" style="top:340.00000762939453px;left:695.666748046875px;"> </div> <div id="el191_off" data-id="191" data-set="STAT3103" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off191" style="top:340.00000762939453px;left:695.666748046875px;"> </div> <div id="el191_ct" class="pw-tooltip" data-id="191"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el192_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray192 pw-gray" style="top:360.6666793823242px;left:691.3334045410156px;"> STAT3 </div> <div id="el192_off" data-id="192" data-set="STAT3103" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off192" style="top:360.6666793823242px;left:691.3334045410156px;"> STAT3</div> <div id="el192_ct" class="pw-tooltip" data-id="192"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el193_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray193 pw-gray" style="top:435.33333587646484px;left:678.6666564941406px;"> </div> <div id="el193_off" data-id="193" data-set="STAT3Dimer104" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off193" style="top:435.33333587646484px;left:678.6666564941406px;"> </div> <div id="el193_ct" class="pw-tooltip" data-id="193"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el194_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray194 pw-gray" style="top:464.33333587646484px;left:668.6666564941406px;"> STAT3 Dimer </div> <div id="el194_off" data-id="194" data-set="STAT3Dimer104" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off194" style="top:464.33333587646484px;left:668.6666564941406px;"> STAT3 Dimer</div> <div id="el194_ct" class="pw-tooltip" data-id="194"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el195_gry" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-gray195 pw-gray" style="top:771.6666870117188px;left:650.6666564941406px;"> </div> <div id="el195_off" data-id="195" data-set="STAT3105" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-sprite el-off195" style="top:771.6666870117188px;left:650.6666564941406px;"> </div> <div id="el195_ct" class="pw-tooltip" data-id="195"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el196_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray196 pw-gray" style="top:760.0000305175781px;left:651.6666564941406px;"> STAT3 </div> <div id="el196_off" data-id="196" data-set="STAT3105" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off196" style="top:760.0000305175781px;left:651.6666564941406px;"> STAT3 </div> <div id="el196_ct" class="pw-tooltip" data-id="196"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=STAT3">STAT3</a><br> </div> </div> <div id="el197_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray197 pw-gray" style="top:755.3333435058594px;left:714.6666564941406px;"> p19 </div> <div id="el197_off" data-id="197" data-set="p19" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off197" style="top:755.3333435058594px;left:714.6666564941406px;"> p19</div> <div id="el197_ct" class="pw-tooltip" data-id="197"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-23">IL-23</a><br> </div> </div> <div id="el198_gry" class="il-12signaling_all il-12signaling_il-39 pw-label el-gray198 pw-gray" style="top:770.6666870117188px;left:714.6666564941406px;"> EBI3 </div> <div id="el198_off" data-id="198" data-set="EBI3" data-type="No Products Click" class="il-12signaling_all il-12signaling_il-39 pw-label el-off198" style="top:770.6666870117188px;left:714.6666564941406px;"> EBI3</div> <div id="el198_ct" class="pw-tooltip" data-id="198"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=IL-27/IL-35 EBI3 Subunit">IL-27/IL-35 EBI3 Subunit</a><br> </div> </div> <div id="el199_off" data-id="199" data-set="il12textbox" data-type="" class="il-12signaling_il-12 pw-label2 pw-none el-off199" style="top:35px;left:120px;"> <div class="pw_txtBox" style="width:220px;text-align: left;"> <div style="width:100%"> <strong>Primary Cytokine-Producing Cells</strong><br> <ul class="pw_list"> <li>Dendritic cells</li> <li>Macrophages</li> <li>Monocytes</li> <li>Neutrophils</li> <li>B cells</li> </ul> <strong>Receptor-Expressing Cells</strong><br> <ul class="pw_list"> <li>IL-12 R beta 1: Constitutively expressed on T cells, natural killer cells, B cells, dendritic cells, macrophages, and microglia</li> <li>IL-12 R beta 2: Activated naïve T cells, natural killer cells, and dendritic cells</li> </ul> <strong>Primary Biological Effects</strong><br> <ul class="pw_list"> <li>Pro-inflammatory</li> <li>Promotes the differentiation of naïve CD4<sup>+</sup> T cells into Th1 cells</li> <li>Enhances the cytotoxicity of natural killer cells and cytotoxic T lymphocytes</li> <li>Induces IFN-gamma production by T cells and natural killer cells</li> <li>Stimulates proliferation of T cells and natural killer cells</li> <li>Influences T cell trafficking</li> </ul> </div> </div> </div> <div id="el199_ct" class="pw-tooltip" data-id="199"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el200_off" data-id="200" data-set="il23textbox" data-type="" class="il-12signaling_il-23 pw-label2 pw-none el-off200" style="top:35px;left:240px;"> <div class="pw_txtBox" style="width:220px;text-align: left;"> <div style="width:100%"> <strong>Primary Cytokine-Producing Cells</strong><br> <ul class="pw_list"> <li>Dendritic cells</li> <li>Macrophages</li> <li>Monocytes</li> <li>CD4<sup>+</sup>CD45RB<sup>low</sup> Memory T cells</li> </ul> <strong>Receptor-Expressing Cells</strong><br> <ul class="pw_list"> <li>IL-23 R: Memory T cells, Th17 cells, gamma delta T cells, natural killer cells, innate lymphoid cells, neutrophils</li> <li>IL-12 R beta 1: Constitutively expressed on T cells, natural killer cells, B cells, dendritic cells, macrophages, and microglia</li> </ul> <strong>Primary Biological Effects</strong><br> <ul class="pw_list"> <li>Pro-inflammatory</li> <li>Promotes the expansion and maintenance of Th17 cells</li> <li>Promotes memory T cell activation and proliferation</li> <li>Stimulates IL-17-mediated neutrophil recruitment to sites of infection</li> <li>Up-regulated in several inflammation-associated pathologies</li> </ul> </div> </div> </div> <div id="el200_ct" class="pw-tooltip" data-id="200"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el201_off" data-id="201" data-set="il27textbox" data-type="" class="il-12signaling_il-27 pw-label2 pw-none el-off201" style="top:35px;left:400px;"> <div class="pw_txtBox" style="width:250px;text-align: left;"> <div style="width:100%"> <strong>Primary Cytokine-Producing Cells</strong><br> <ul class="pw_list"> <li>Dendritic cells</li> <li>Macrophages</li> <li>Monocytes</li> </ul> <strong>Receptor-Expressing Cells</strong><br> <ul class="pw_list"> <li>IL-27 R alpha/WSX-1: Naïve, effector, and memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells, natural killer cells, natural killer T cells, dendritic cells, B cells, monocytes, macrophages, mast cells, and endothelial cells</li> <li>gp130: Ubiquitously expressed by immune and non-immune cell types</li> </ul> <strong>Primary Biological Effects</strong><br> <ul class="pw_list"> <li>Pro- and Anti-inflammatory</li> <li>Promotes early Th1 commitment through induction of T-bet</li> <li>Enhances naïve CD4<sup>+</sup> T cell proliferation</li> <li>Inhibits Th17 differentiation and IL-17 production</li> <li>Induces the conversion of activated, differentiated effector T cells into IL-10-producing, immunosuppressive T regulatory type I-like (Tr1-like) cells</li> <li>Promotes the effector functions of natural killer cells and CD8<sup>+</sup> T cells</li> <li>Facilitates the development and survival of follicular helper T (Tfh) cells via the induction of IL-21 and other hallmark Tfh genes</li> <li>Modulates B cell Ig class switching</li> <li>Induces mast cell activation</li> </ul> </div> </div> </div> <div id="el201_ct" class="pw-tooltip" data-id="201"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el202_off" data-id="202" data-set="il35textbox" data-type="" class="il-12signaling_il-35 pw-label2 pw-none el-off202" style="top:35px;left:45px;"> <div class="pw_txtBox" style="width:235px;text-align: left;"> <div style="width:100%"> <strong>Primary Cytokine-Producing Cells</strong><br> <ul class="pw_list"> <li>Regulatory T cells (Tregs)</li> <li>Regulatory B cells (Bregs)</li> </ul> <strong>Receptor-Expressing Cells</strong><br> <ul class="pw_list"> <li>IL-12 R beta 2: Activated naïve T cells, natural killer cells, and dendritic cells</li> <li>gp130: Ubiquitously expressed by immune and non-immune cell types</li> <li>IL-27 R alpha/WSX-1: Naïve, effector, and memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells, natural killer cells, natural killer T cells, dendritic cells, B cells, monocytes, macrophages, mast cells, and endothelial cells</li> </ul> <strong>Primary Biological Effects</strong><br> <strong>IL-12 R beta 2-gp130 Heterodimeric Receptor:</strong><br> <ul class="pw_list"> <li>Anti-inflammatory</li> <li>Suppresses the proliferation of conventional T cells</li> <li>Induces the conversion of naïve conventional T cells into IL-35-producing induced regulatory T cells (iTr35 cells)</li> <li>Enhances regulatory T cell proliferation</li> </ul> <strong>IL-12 R beta 2-IL-12 R beta 2 or gp130-gp130 Homodimeric Receptors:</strong><br> <ul class="pw_list"> <li>Partial suppression of the proliferation of conventional T cells</li> </ul> <strong>IL-12 R beta 2-IL-27 R alpha/WSX-1 Heterodimeric Receptor: </strong><br> <ul class="pw_list"> <li>Induces the conversion of B cells into IL-35-, IL-10-producing regulatory B cells and promotes their expansion</li> </ul> </div> </div> </div> <div id="el202_ct" class="pw-tooltip" data-id="202"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el203_off" data-id="203" data-set="il39textbox" data-type="" class="il-12signaling_il-39 pw-label2 pw-none el-off203" style="top:35px;left:300px;"> <div class="pw_txtBox" style="width:320px;text-align: left;"> <div style="width:100%"> <strong>Primary Cytokine-Producing Cells</strong><br> <ul class="pw_list"> <li>Activated B cells</li> <li>Keratinocytes</li> </ul> <strong>Receptor-Expressing Cells</strong><br> <ul class="pw_list"> <li>IL-23 R: Memory T cells, Th17 cells, gamma delta T cells, natural killer cells, innate lymphoid cells, neutrophils</li> <li>gp130: Ubiquitously expressed by a variety of immune and non-immune cell types</li> </ul> <strong>Primary Biological Effects</strong><br> <ul class="pw_list"> <li>Regulates inflammatory responses</li> <li>Induces neutrophil expansion or differentiation</li> <li>Stimulates BAFF secretion by neutrophils</li> <li>Associated with the pathophysiology of SLE and other autoimmune diseases</li> </ul> </div> </div> </div> <div id="el203_ct" class="pw-tooltip" data-id="203"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/il-12-family-static-color.png?t=2" alt="IL-12 Family Signaling Pathways" style="height:943px"> </div> </div> <div id="pathway-description"><p><h2>Overview of the IL-12 Cytokine Family</h2> <p>The IL-12 family of heterodimeric cytokines includes IL-12, IL-23, IL-27, IL-35, and IL-39. The first three of these cytokines are produced primarily by dendritic cells, macrophages, and monocytes, while IL-35 is produced by regulatory T (Treg) and regulatory B (Breg) cells, and IL-39 is secreted by activated B cells and keratinocytes. Each of the IL-12 family cytokines consists of two subunits: an alpha chain (p19, p28, or p35) with a four alpha-helix bundle structure and a beta chain (p40 or EBI3) that is homologous to the soluble class I cytokine receptor chains. The alpha and beta chain subunits are shared among different members of the IL-12 family. IL-12 is composed of the p35 alpha chain and the p40 beta chain, which are covalently linked by a disulfide bond to form the IL-12 p70 protein. IL-23 also contains the IL-12 p40 subunit, but in this case, it is disulfide-linked to the p19 alpha chain, which shares homology with IL-12 p35. Similarly, IL-27, IL-35, and IL-39 consist in part of a shared IL-12/IL-23 p40-related protein known as Epstein-Barr virus-induced gene 3 (EBI3). EBI3 pairs with either p28, a polypeptide related to IL-12 p35, to form IL-27, or with p35 to form IL-35, or p19 to form IL-39.</p> <p>Due to similarities in the subunit composition of the IL-12 family cytokines, many of the receptors for these cytokines also have common chains and activate seemingly comparable downstream signaling pathways. IL-12 and IL-23 both signal through heterodimeric receptor complexes that contain IL-12 R beta 1 paired with either IL-12 R beta 2 for the IL-12 receptor or with IL-23 R for the IL-23 receptor. Likewise, the receptor complexes for IL-27, IL-35, and IL-39 all contain gp130, a common receptor subunit shared with the IL-6 family cytokines. gp130 couples with IL-27 R alpha/WSX-1 to form the IL-27 receptor complex, with IL-12 R beta 2 to form the IL-35 receptor complex in T cells, or with IL-23 R to form the IL-39 receptor complex. Additionally, homodimers of gp130 or IL-12 R beta 2 have also been shown to elicit a partial IL-35-induced response in T cells, while in B cells, IL-35 has been shown to signal through a receptor complex comprised of IL-12 R beta 2 and IL-27 R alpha/WSX-1. Following receptor binding, all members of the IL-12 family trigger the activation of Jak2 along with Tyk2 and/or Jak1, leading to the phosphorylation of a subset of STAT proteins, which then homodimerize or heterodimerize and translocate to the nucleus where they induce the expression of target genes. Although multiple STAT proteins may be activated by each IL-12 family cytokine, typically the biological effects associated with different cytokines have been attributed to the activities of one or two STAT proteins. The primary STATs required for signaling by each IL-12 family cytokine are shown as the larger, more brightly colored STAT molecules in the signaling pathways presented in the graphic (refer to the key at the bottom of the pathway).</p> <p>Despite similarities in the signaling pathways that they activate, cytokines belonging to the IL-12 family have distinct effects on the immune response. A number of these effects are brought about by the ability of the IL-12 family cytokines to differentially regulate the activities of specific T cell subsets. Signaling induced by IL-12 promotes the differentiation of na&iuml;ve CD4<sup>+</sup> T cells into Th1 cells, induces proliferation and IFN-gamma production by natural killer (NK) cells and T cells, and enhances the cytotoxicity of NK cells and cytotoxic T lymphocytes. In contrast, IL-23 signaling is involved in the stabilization and maintenance of Th17 cells, promotes memory T cell activation, and stimulates IL-17-mediated neutrophil recruitment to sites of infection. Although these activities demonstrate that IL-12 and IL-23 induce different immune responses, both can be characterized as pro-inflammatory.</p> <p>IL-27 is unique in that it has both pro-inflammatory and anti-inflammatory effects. IL-27 drives inflammation by promoting the early commitment of na&iuml;ve CD4<sup>+</sup> T cells to a Th1-specific lineage through the induction of T-bet, but it also suppresses inflammation by inhibiting Th17 differentiation and inducing the conversion of effector T cells into IL-10-producing T regulatory type I-like (Tr1-like) cells. This functional dichotomy suggests that IL-27 may play a critical role in regulating the delicate balance between pro- and anti-inflammatory signaling. Additionally, IL-27 promotes the survival and function of T follicular helper cells and enhances the functions of germinal center B cells.</p> <p>Unlike other IL-12 family members, IL-35 seems to function solely as an anti-inflammatory cytokine. It enhances regulatory T cell proliferation, suppresses the proliferation of conventional T cells, and induces the conversion of na&iuml;ve conventional T cells into IL-35-producing induced regulatory T cells (iTr35 cells). Additionally, it promotes the conversion of B cells into IL-10-, IL-35-producing regulatory B cells. As a result, IL-35 has been suggested to be involved in inhibiting the pathogenesis of autoimmune and inflammatory diseases. </p> <p>Although only a few studies have been published on IL-39 to date, its observed activities suggest that it has pro-inflammatory effects. IL-39 has been shown to induce neutrophil expansion or differentiation and to stimulate BAFF production by these cells, which has been implicated in the pathophysiology of systemic lupus erythematosus (SLE) and other autoimmune diseases. IL-39 has also been found to be secreted by keratinocytes, but whether it has protective or pathogenic effects in the skin awaits further investigation.</p> <p>To learn more, please visit our <a href="/research-area/il--12-family">IL-12 Family Research Area</a>.</p></p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/il-12-family-signaling-pathways" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item webform-component 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and Barbuda</option><option value="AR">Argentina</option><option value="AM">Armenia</option><option value="AW">Aruba</option><option value="AU">Australia</option><option value="AT">Austria</option><option value="AZ">Azerbaijan</option><option value="BS">Bahamas</option><option value="BH">Bahrain</option><option value="BD">Bangladesh</option><option value="BB">Barbados</option><option value="BE">Belgium</option><option value="BZ">Belize</option><option value="BJ">Benin</option><option value="BM">Bermuda</option><option value="BO">Bolivia</option><option value="BA">Bosnia and Herzegovina</option><option value="BW">Botswana</option><option value="BR">Brazil</option><option value="BN">Brunei</option><option value="BG">Bulgaria</option><option value="BF">Burkina Faso</option><option value="BI">Burundi</option><option value="KH">Cambodia</option><option value="CM">Cameroon</option><option value="CA">Canada</option><option value="KY">Cayman Islands</option><option value="CF">Central African 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