Computational biology and bioinformatics - Latest research and news

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id="title" class="u-container" data-container-type="title"> <div class="l-with-sidebar" style="--with-sidebar--gap: 1em"> <h1 class="u-mb-16">Computational biology and bioinformatics articles from across Nature Portfolio</h1> <ul class="inline-list l-with-sidebar__sidebar" style="--with-sidebar--basis: auto"> <li class="ml15 text13"><a href="/subjects/computational-biology-and-bioinformatics.atom" data-track="click" data-track-category="feeds" data-track-action="link:atom" data-track-label="/subjects/computational-biology-and-bioinformatics.atom" class="icon icon-left icon-tools-feed-16x16-color pl20">Atom</a></li> <li class="ml15 text13"><a href="/subjects/computational-biology-and-bioinformatics.rss" data-track="click" data-track-category="feeds" data-track-action="link:rss" data-track-label="/subjects/computational-biology-and-bioinformatics.rss" class="icon icon-left icon-tools-feed-16x16-color pl20">RSS Feed</a></li> </ul> <section class="u-mb-32"> <button class="text-blue pr20 inline-block position-relative icon-rotate icon-arrow-down-12x7-gray link-like js-hide js-mq640-show" data-toggle="collapsible-section" data-target="definition">Definition</button> <p class="tight-line-height js-mq640-hide" id="definition">Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation. </p> </section> </div> </div> <section class="u-container u-mb-48"><h2 class="c-section-heading">Featured</h2> <ul class="c-list-group c-list-group--lg c-list-group--bordered c-list-group--flush app-article-list-row"> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs42256-025-00990-3/MediaObjects/42256_2025_990_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs42256-025-00990-3/MediaObjects/42256_2025_990_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs42256-025-00990-3/MediaObjects/42256_2025_990_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s42256-025-00990-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">On board with COMET to improve omics prediction models</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The performance of omics prediction models can be significantly improved by combining limited patient proteomic data with widely available electronic health records.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Paul Fogel</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">George Luta</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-12" itemprop="datePublished">12 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/natmachintell" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Machine Intelligence</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">P: 1-2</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41571-025-00999-y" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">AI accurately identifies targetable alterations in lung cancer histological images</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>DeepGEM, an artificial intelligence (AI)-based model, accurately predicts the presence of key genomic alterations in histological slides prepared from samples obtained from patients with lung cancer. This approach provides a cost-effective alternative to genomic testing, generates spatial mutation maps and might support personalized treatment strategies. Validated in diverse datasets, DeepGEM highlights the potential of AI to transform precision oncology and improve global healthcare equity.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Hortense Le</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Aristotelis Tsirigos</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-10" itemprop="datePublished">10 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nrclinonc" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Clinical Oncology</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">P: 1-2</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-02073-2/MediaObjects/41588_2024_2073_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02073-2/MediaObjects/41588_2024_2073_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02073-2/MediaObjects/41588_2024_2073_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-02073-2" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Unveiling heterogeneity in rare cells by combining RNA-based sorting and scRNA-seq</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>A study describes the development of PERFF-seq, a method to ‘FISH’ out rare cells using RNA markers, helping to solve the challenge in single-cell biology of studying cells that make up less than 1% of a sample.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Madison Wahlsten</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sydney M. Shaffer</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-07" itemprop="datePublished">07 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/ng" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Genetics</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 57, P: 283-284</div> </div> </article> </li> </ul> </section> <section class="u-container u-mb-48 u-pb-24"> <h2 class="c-section-heading">Related Subjects</h2> <ul class="ma0 clean-list tighten-line-height grid-auto-fill no-row-gap" id="related-subjects-list"> <li class="pb4"> <a href="/subjects/biochemical-reaction-networks" class="subject-tag-link text14" data-track="click" 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class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41598-025-85802-9/MediaObjects/41598_2025_85802_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-025-85802-9/MediaObjects/41598_2025_85802_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-025-85802-9/MediaObjects/41598_2025_85802_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41598-025-85802-9" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Dense convolution-based attention network for Alzheimer’s disease classification</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yingtong Gan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Quan Lan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Zhiyuan Huang</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-17" itemprop="datePublished">17 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/srep" data-track="click" data-track-action="clicked journal" data-track-label="link">Scientific Reports</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 15, P: 5693</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41467-025-57029-9/MediaObjects/41467_2025_57029_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-025-57029-9/MediaObjects/41467_2025_57029_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-025-57029-9/MediaObjects/41467_2025_57029_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41467-025-57029-9" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Deciphering the features, structure, and functions of the cell niche in tissues remains a major challenge. Here, the authors develop scNiche, a computational framework to identify and characterise cell niches from spatial omics data at single-cell resolution.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Jingyang Qian</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xin Shao</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiaohui Fan</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-16" itemprop="datePublished">16 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/ncomms" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Communications</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 16, P: 1693</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41467-025-57027-x/MediaObjects/41467_2025_57027_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-025-57027-x/MediaObjects/41467_2025_57027_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-025-57027-x/MediaObjects/41467_2025_57027_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41467-025-57027-x" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Topological identification and interpretation for single-cell epigenetic regulation elucidation in multi-tasks using scAGDE</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Single-cell ATAC-seq reveals gene regulation at individual cell levels but struggles with data sparsity. Here, authors introduce scAGDE, a deep graph learning framework that improves cell embedding and clustering, outperforming existing methods and uncovering key regulatory mechanisms.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Gaoyang Hao</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yi Fan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiangtao Li</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-16" itemprop="datePublished">16 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/ncomms" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Communications</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 16, P: 1691</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs42003-025-07694-9/MediaObjects/42003_2025_7694_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs42003-025-07694-9/MediaObjects/42003_2025_7694_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs42003-025-07694-9/MediaObjects/42003_2025_7694_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s42003-025-07694-9" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">RNA-protein interaction prediction using network-guided deep learning</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>This study has developed a new method to predict RNA-protein interactions by combining graph neural networks and unsupervised large language models. The model showed superior performances by benchmark tests, especially for previously unseen RNAs and proteins.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Haoquan Liu</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yiren Jian</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yunjie Zhao</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-16" itemprop="datePublished">16 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/commsbio" data-track="click" data-track-action="clicked journal" data-track-label="link">Communications Biology</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 8, P: 247</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41598-025-89905-1/MediaObjects/41598_2025_89905_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-025-89905-1/MediaObjects/41598_2025_89905_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-025-89905-1/MediaObjects/41598_2025_89905_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41598-025-89905-1" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Predicting preterm birth using machine learning methods</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Anna Kloska</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Alicja Harmoza</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Iwona Sadowska-Krawczenko</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-16" itemprop="datePublished">16 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/srep" data-track="click" data-track-action="clicked journal" data-track-label="link">Scientific Reports</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 15, P: 5683</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41598-025-89333-1/MediaObjects/41598_2025_89333_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-025-89333-1/MediaObjects/41598_2025_89333_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-025-89333-1/MediaObjects/41598_2025_89333_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41598-025-89333-1" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Classification patterns identification of immunogenic cell death-related genes in heart failure based on deep learning</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Zhihui Ma</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Shixin Ma</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yu Hu</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-15" itemprop="datePublished">15 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/srep" data-track="click" data-track-action="clicked journal" data-track-label="link">Scientific Reports</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 15, P: 5633</div> </div> </article> </li> </ul> <div class="position-left last text-center u-mb-48"> <a href="/search?article_type=protocols,research,reviews&subject=computational-biology-and-bioinformatics" class="pill-button inline-block" data-track="click" data-track-action="link:view-all" data-track-category="latest-research" data-track-label="All Research & Reviews"><span>All Research & Reviews</span></a> </div> <section class="u-container u-mb-48"> <div id="div-gpt-ad-article-list-2" class="div-gpt-ad medium-rectangle c-ad c-ad--300x250 advert js-ad hide-print grade-c-hide" data-ad-type="article-list" data-test="article-list-ad" data-pa11y-ignore data-gpt data-gpt-unitpath="/285/subjects/computational-biology-and-bioinformatics" data-gpt-sizes="300x250" data-gpt-targeting="pos=article-list;artid=;path=" > <noscript> <a href="//pubads.g.doubleclick.net/gampad/jump?iu=/285/subjects/computational-biology-and-bioinformatics&sz=300x250&c=-1768538089&t=pos%3Darticle-list%26artid%3D"> <img data-test="gpt-advert-fallback-img" src="//pubads.g.doubleclick.net/gampad/ad?iu=/285/subjects/computational-biology-and-bioinformatics&sz=300x250&c=-1768538089&t=pos%3Darticle-list%26artid%3D" alt="Advertisement" width="300" height="250"/> </a> </noscript> </div> </section> </section> <section class="u-container u-mb-48"> <h2 class="c-section-heading">News and Comment</h2> <ul class="c-list-group c-list-group--lg c-list-group--bordered c-list-group--flush app-article-list-row"> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/magazine-assets/d41586-025-00488-3/d41586-025-00488-3_50636094.jpg?as=webp 160w, https://media.springernature.com/w290h158/magazine-assets/d41586-025-00488-3/d41586-025-00488-3_50636094.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/magazine-assets/d41586-025-00488-3/d41586-025-00488-3_50636094.jpg" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/d41586-025-00488-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Scientists use AI to design life-like enzymes from scratch</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Combined approach takes AI-engineered enzymes one step closer to practical applications.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Miryam Naddaf</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-13" itemprop="datePublished">13 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nature" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature</a></span> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs42256-025-00990-3/MediaObjects/42256_2025_990_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs42256-025-00990-3/MediaObjects/42256_2025_990_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs42256-025-00990-3/MediaObjects/42256_2025_990_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s42256-025-00990-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">On board with COMET to improve omics prediction models</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The performance of omics prediction models can be significantly improved by combining limited patient proteomic data with widely available electronic health records.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Paul Fogel</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">George Luta</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-12" itemprop="datePublished">12 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/natmachintell" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Machine Intelligence</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">P: 1-2</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/magazine-assets/d41586-025-00402-x/d41586-025-00402-x_50621714.jpg?as=webp 160w, https://media.springernature.com/w290h158/magazine-assets/d41586-025-00402-x/d41586-025-00402-x_50621714.jpg?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/magazine-assets/d41586-025-00402-x/d41586-025-00402-x_50621714.jpg" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/d41586-025-00402-x" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Why is mathematics education failing some of the world’s most talented children?</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>A study shines a light on the remarkable arithmetic skills that young people acquire outside formal schooling. Education must evolve to enable them to fulfil their potential.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Editorial</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-12" itemprop="datePublished">12 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nature" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 638, P: 293</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41576-025-00820-7" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Genomic data sharing: you don’t know what you’ve got (till it’s gone)</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Reflecting on the core values of early data sharing agreements, the Bermuda Principles and the Fort Lauderdale Agreement, Kathryn E. Holt and Michael Inouye emphasize the need to reaffirm our commitment to genomic data sharing to shape the future of science.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Kathryn E. Holt</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Michael Inouye</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Comments & Opinion</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-12" itemprop="datePublished">12 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nrg" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Reviews Genetics</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">P: 1-2</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41592-025-02607-4" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">RNA-seq coverage prediction</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Lin Tang</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research Highlights</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2025-02-11" itemprop="datePublished">11 Feb 2025</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nmeth" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Methods</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 22, P: 225</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44159-025-00416-2" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Generative AI in psychology</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Research using generative artificial intelligence (AI) has been accelerating across many disciplines. 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