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Rajak</title> <meta name="description" content="Search results for: Debobrata Rajak"> <meta name="keywords" content="Debobrata Rajak"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Debobrata Rajak" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Debobrata Rajak"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 14</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Debobrata Rajak</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Interaction of Tungsten Tips with Laguerre-Gaussian Beams</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abhisek%20Sinha">Abhisek Sinha</a>, <a href="https://publications.waset.org/abstracts/search?q=Debobrata%20Rajak"> Debobrata Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Shilpa%20Rani"> Shilpa Rani</a>, <a href="https://publications.waset.org/abstracts/search?q=Ram%20Gopal"> Ram Gopal</a>, <a href="https://publications.waset.org/abstracts/search?q=Vandana%20Sharma"> Vandana Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The interaction of femtosecond laser pulses with metallic tips has been studied extensively, and they have proved to be a very good source of ultrashort electron pulses. A study of the interaction of femtosecond Laguerre-Gaussian (LG) laser modes with Tungsten tips is presented here. Laser pulses of 35 fs pulse durations were incident on Tungsten tips, and their electron emission rates were studied for LG (l=1, p=0) and Gaussian modes. A change in the order of the interaction for LG beams is reported, and the difference in the order of interaction is attributed to ponderomotive shifts in the energy levels corresponding to the enhanced near-field intensity supported by numerical simulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=femtosecond" title="femtosecond">femtosecond</a>, <a href="https://publications.waset.org/abstracts/search?q=Laguerre-Gaussian" title=" Laguerre-Gaussian"> Laguerre-Gaussian</a>, <a href="https://publications.waset.org/abstracts/search?q=OAM" title=" OAM"> OAM</a>, <a href="https://publications.waset.org/abstracts/search?q=tip" title=" tip"> tip</a> </p> <a href="https://publications.waset.org/abstracts/139164/interaction-of-tungsten-tips-with-laguerre-gaussian-beams" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139164.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">265</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Studies on the Feasibility of Cow Dung as a Non-Conventional Energy Source</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raj%20Kumar%20Rajak">Raj Kumar Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Bharat%20Mishra"> Bharat Mishra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bio-batteries represent an entirely new long-term, reasonable, reachable and ecofriendly approach to produce sustainable energy. In the present experimental work, we have studied the effect of generation of power by bio-battery using different electrode pairs. The tests show that it is possible to generate electricity using cow dung as an electrolyte. C-Mg electrode pair shows maximum voltage and SCC (Short Circuit Current) while C-Zn electrode pair shows less OCV (Open Circuit Voltage) and SCC. We have chosen C-Zn electrodes because Mg electrodes are not economical. By the studies of different electrodes and cow dung, it is found that C-Zn electrode battery is more suitable. This result shows that the bio-batteries have the potency to full fill the need of electricity demand for lower energy equipment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bio-batteries" title="bio-batteries">bio-batteries</a>, <a href="https://publications.waset.org/abstracts/search?q=electricity" title=" electricity"> electricity</a>, <a href="https://publications.waset.org/abstracts/search?q=cow-dung" title=" cow-dung"> cow-dung</a>, <a href="https://publications.waset.org/abstracts/search?q=electrodes" title=" electrodes"> electrodes</a>, <a href="https://publications.waset.org/abstracts/search?q=non-conventional" title=" non-conventional"> non-conventional</a> </p> <a href="https://publications.waset.org/abstracts/82579/studies-on-the-feasibility-of-cow-dung-as-a-non-conventional-energy-source" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82579.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">205</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Customized Cow’s Urine Battery Using MnO2 Depolarizer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raj%20Kumar%20Rajak">Raj Kumar Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Bharat%20Mishra"> Bharat Mishra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bio-battery represents an entirely new long term, reasonable, reachable and ecofriendly approach to production of sustainable energy. Types of batteries have been developed using MnO<sub>2</sub> in various ways. MnO<sub>2 </sub>is suitable with physical, chemical, electrochemical, and catalytic properties, serving as an effective cathodic depolarizer and may be considered as being the life blood of the battery systems. In the present experimental work, we have studied the effect of generation of power by bio-battery using different concentrations of MnO<sub>2</sub>. The tests show that it is possible to generate electricity using cow’s urine as an electrolyte. After ascertaining the optimum concentration of MnO<sub>2</sub>, various battery parameters and performance indicates that cow urine solely produces power of 695 mW, while a combination with MnO<sub>2</sub> (40%) enhances power of bio-battery, i.e. 1377 mW. On adding more and more MnO<sub>2 </sub>to the electrolyte, the power suppressed because inflation of internal resistance. The analysis of the data produced from experiment shows that MnO<sub>2</sub> is quite suitable to energize the bio-battery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bio-batteries" title="bio-batteries">bio-batteries</a>, <a href="https://publications.waset.org/abstracts/search?q=cow%E2%80%99s%20urine" title=" cow’s urine"> cow’s urine</a>, <a href="https://publications.waset.org/abstracts/search?q=manganese%20dioxide" title=" manganese dioxide"> manganese dioxide</a>, <a href="https://publications.waset.org/abstracts/search?q=non-conventional" title=" non-conventional"> non-conventional</a> </p> <a href="https://publications.waset.org/abstracts/81623/customized-cows-urine-battery-using-mno2-depolarizer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81623.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">261</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Studies on the Feasibility of Cow’s Urine as Non-Conventional Energy Sources</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raj%20Kumar%20Rajak">Raj Kumar Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Bharat%20Mishra"> Bharat Mishra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bio-batteries represent an entirely new long-term, reasonable, reachable, and eco-friendly approach to generation of sustainable energy. In the present experimental work, we have studied the effect of the generation of power by bio-battery using different electrode pairs. The tests show that it is possible to generate electricity using cow’s urine as an electrolyte. C-Mg electrode pair shows maximum Voltage and Short Circuit Current (SCC), while C-Zn electrode pair shows less Open Circuit Voltage (OCV) and SCC. By the studies of cow urine and different electrodes, it is found that C-Zn electrode battery is more economical. The cow urine battery with C-Zn electrode provides maximum power (707.4 mW) and durability (up to 145 h). This result shows that the bio-batteries have the potency to full fill the need of electricity demand for lower energy equipment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bio-batteries" title="bio-batteries">bio-batteries</a>, <a href="https://publications.waset.org/abstracts/search?q=cow%27s%20urine" title=" cow's urine"> cow's urine</a>, <a href="https://publications.waset.org/abstracts/search?q=electrodes" title=" electrodes"> electrodes</a>, <a href="https://publications.waset.org/abstracts/search?q=non-conventional" title=" non-conventional"> non-conventional</a> </p> <a href="https://publications.waset.org/abstracts/92684/studies-on-the-feasibility-of-cows-urine-as-non-conventional-energy-sources" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92684.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">202</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Avoiding Packet Drop for Improved through Put in the Multi-Hop Wireless N/W</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manish%20Kumar%20Rajak">Manish Kumar Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Gupta"> Sanjay Gupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mobile ad hoc networks (MANETs) are infrastructure less and intercommunicate using single-hop and multi-hop paths. Network based congestion avoidance which involves managing the queues in the network devices is an integral part of any network. QoS: A set of service requirements that are met by the network while transferring a packet stream from a source to a destination. Especially in MANETs, packet loss results in increased overheads. This paper presents a new algorithm to avoid congestion using one or more queue on nodes and corresponding flow rate decided in advance for each node. When any node attains an initial value of queue then it sends this status to its downstream nodes which in turn uses the pre-decided flow rate of packet transfer to its upstream nodes. The flow rate on each node is adjusted according to the status received from its upstream nodes. This proposed algorithm uses the existing infrastructure to inform to other nodes about its current queue status. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mesh%20networks" title="mesh networks">mesh networks</a>, <a href="https://publications.waset.org/abstracts/search?q=MANET" title=" MANET"> MANET</a>, <a href="https://publications.waset.org/abstracts/search?q=packet%20count" title=" packet count"> packet count</a>, <a href="https://publications.waset.org/abstracts/search?q=threshold" title=" threshold"> threshold</a>, <a href="https://publications.waset.org/abstracts/search?q=throughput" title=" throughput"> throughput</a> </p> <a href="https://publications.waset.org/abstracts/23702/avoiding-packet-drop-for-improved-through-put-in-the-multi-hop-wireless-nw" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23702.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">474</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> A Review on Electrical Behavior of Different Substrates, Electrodes and Membranes in Microbial Fuel Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bharat%20Mishra">Bharat Mishra</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Kumar%20Awasthi"> Sanjay Kumar Awasthi</a>, <a href="https://publications.waset.org/abstracts/search?q=Raj%20Kumar%20Rajak"> Raj Kumar Rajak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The devices, which convert the energy in the form of electricity from organic matters, are called microbial fuel cell (MFC). Recently, MFCs have been given a lot of attention due to their mild operating conditions, and various types of biodegradable substrates have been used in the form of fuel. Traditional MFCs were included in anode and cathode chambers, but there are single chamber MFCs. Microorganisms actively catabolize substrate, and bioelectricities are produced. In the field of power generation from non-conventional sources, apart from the benefits of this technique, it is still facing practical constraints such as low potential and power. In this study, most suitable, natural, low cost MFCs components are electrodes (anode and cathode), organic substrates, membranes and its design is selected on the basis of maximum potential (voltage) as an electrical parameter, which indicates a vital role of affecting factor in MFC for sustainable power production. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=substrates" title="substrates">substrates</a>, <a href="https://publications.waset.org/abstracts/search?q=electrodes" title=" electrodes"> electrodes</a>, <a href="https://publications.waset.org/abstracts/search?q=membranes" title=" membranes"> membranes</a>, <a href="https://publications.waset.org/abstracts/search?q=MFCs%20design" title=" MFCs design"> MFCs design</a>, <a href="https://publications.waset.org/abstracts/search?q=voltage" title=" voltage"> voltage</a> </p> <a href="https://publications.waset.org/abstracts/77437/a-review-on-electrical-behavior-of-different-substrates-electrodes-and-membranes-in-microbial-fuel-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77437.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">306</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> A Metaheuristic Approach for the Pollution-Routing Problem</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Parthiban">P. Parthiban</a>, <a href="https://publications.waset.org/abstracts/search?q=Sonu%20Rajak"> Sonu Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Dhanalakshmi"> R. Dhanalakshmi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents an Ant Colony Optimization (ACO) approach, combined with a Speed Optimization Algorithm (SOA) to solve the Vehicle Routing Problem (VRP) with environmental considerations, which is well known as Pollution-Routing Problem (PRP). It consists of routing a number of vehicles to serve a set of customers, and determining fuel consumption, driver wages and their speed on each route segment, while respecting the capacity constraints and time windows. Since VRP is NP-hard problem, so PRP also a NP-hard problem, which requires metaheuristics to solve this type of problems. The proposed solution method consists of two stages. Stage one is to solve a Vehicle Routing Problem with Time Window (VRPTW) using ACO and in the second stage, a SOA is run on the resulting VRPTW solution. Given a vehicle route, the SOA consists of finding the optimal speed on each arc of the route to minimize an objective function comprising fuel consumption costs and driver wages. The proposed algorithm tested on benchmark problem, the preliminary results show that the proposed algorithm can provide good solutions within reasonable computational time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ant%20colony%20optimization" title="ant colony optimization">ant colony optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=CO2%20emissions" title=" CO2 emissions"> CO2 emissions</a>, <a href="https://publications.waset.org/abstracts/search?q=speed%20optimization" title=" speed optimization"> speed optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=vehicle%20routing" title=" vehicle routing"> vehicle routing</a> </p> <a href="https://publications.waset.org/abstracts/50237/a-metaheuristic-approach-for-the-pollution-routing-problem" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50237.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">359</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Eco-Friendly Electricity Production from the Waste Heat of Air Conditioners</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anvesh%20Rajak">Anvesh Rajak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This is a new innovation that can be developed. Here I am going to use the waste heat of air conditioner so as to produce the electricity by using the Stirling engine because this waste heat creates the thermal pollution in the environment. The waste heat from the air conditioners has caused a temperature rise of 1°–2°C or more on weekdays in the Tokyo office areas. This heating promotes the heat-island phenomenon in Tokyo on weekdays. Now these air conditioners creates the thermal pollution in the environment and hence rising the temperature of the environment. Air conditioner generally emit the waste heat air whose temperature is about 50°C which heat the environment. Today the demand of energy is increasing tremendously, but available energy lacks in supply. Hence, there is no option for proper and efficient utilization and conservation of energy. In this paper the main stress is given on energy conservation by using technique of utilizing waste heat from Air-conditioning system. Actually the focus is on the use of the waste heat rather than improving the COP of the air- conditioners; if also we improve the COP of air conditioners gradually it would emit some waste heat so I want that waste heat to be used up. As I have used air conditioner’s waste heat to produce electricity so similarly there are various other appliances which emit the waste heat in the surrounding so here also we could use the Stirling engines and Geothermal heat pump concept to produce the electricity and hence can reduce the thermal pollution in the environment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=stirling%20engine" title="stirling engine">stirling engine</a>, <a href="https://publications.waset.org/abstracts/search?q=geothermal%20heat%20pumps" title=" geothermal heat pumps"> geothermal heat pumps</a>, <a href="https://publications.waset.org/abstracts/search?q=waste%20heat" title=" waste heat"> waste heat</a>, <a href="https://publications.waset.org/abstracts/search?q=air%20conditioners" title=" air conditioners"> air conditioners</a> </p> <a href="https://publications.waset.org/abstracts/21473/eco-friendly-electricity-production-from-the-waste-heat-of-air-conditioners" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21473.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">359</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> An Ant Colony Optimization Approach for the Pollution Routing Problem</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Parthiban">P. Parthiban</a>, <a href="https://publications.waset.org/abstracts/search?q=Sonu%20Rajak"> Sonu Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Kannan"> N. Kannan</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Dhanalakshmi"> R. Dhanalakshmi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper deals with the Vehicle Routing Problem (VRP) with environmental considerations which is called Pollution Routing Problem (PRP). The objective is to minimize the operational and environmental costs. It consists of routing a number of vehicles to serve a set of customers, and determining fuel consumption, driver wages and their speed on each route segment, while respecting the capacity constraints and time windows. In this context, we presented an Ant Colony Optimization (ACO) approach, combined with a Speed Optimization Algorithm (SOA) to solve the PRP. The proposed solution method consists of two stages. Stage one is to solve a Vehicle Routing Problem with Time Window (VRPTW) using ACO and in the second stage a SOA is run on the resulting VRPTW solutions. Given a vehicle route, the SOA consists of finding the optimal speed on each arc of the route in order to minimize an objective function comprising fuel consumption costs and driver wages. The proposed algorithm tested on benchmark problem, the preliminary results show that the proposed algorithm is able to provide good solutions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ant%20colony%20optimization" title="ant colony optimization">ant colony optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=CO2%20emissions" title=" CO2 emissions"> CO2 emissions</a>, <a href="https://publications.waset.org/abstracts/search?q=combinatorial%20optimization" title=" combinatorial optimization"> combinatorial optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=speed%20optimization" title=" speed optimization"> speed optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=vehicle%20routing" title=" vehicle routing"> vehicle routing</a> </p> <a href="https://publications.waset.org/abstracts/52973/an-ant-colony-optimization-approach-for-the-pollution-routing-problem" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52973.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">322</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Novel Pyrimidine Based Semicarbazones: Confirmation of Four Binding Site Pharmacophoric Model Hypothesis for Antiepileptic Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harish%20Rajak">Harish Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Swati%20Singh"> Swati Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A series of novel pyrimidine based semicarbazone were designed and synthesized on the basis of semicarbazone based pharmacophoric model to satisfy the structural prerequisite crucial for antiepileptic activity. The semicarbazones based pharmacophoric model consists of following four essential binding sites: (i) An aryl hydrophobic binding site with halo substituent; (ii) A hydrogen bonding domain; (iii) An electron donor group and (iv) Another hydrophobic-hydrophilic site controlling the pharmacokinetic features of the anticonvulsant. The aryl semicarbazones has been recognized as a structurally novel class of compounds with remarkable anticonvulsant activity. In the present study, all the test semicarbazones were subjected to molecular docking using Glide v5.8. Some of the compounds were found to interact with ARG192, GLU270 and THR353 residues of 1OHV protein, present in GABA-AT receptor. The chemical structures of the synthesized molecules were characterized by elemental and spectral (IR, 1H NMR, 13C NMR and MS) analysis. The anticonvulsant activities of the compounds were investigated using maximal electroshock seizure (MES) and subcutaneous pentylenetrtrazole (scPTZ) models. The neurotoxicity was evaluated in mice by the rotorod test. The attempts were also made to establish structure-activity relationships among synthesized compounds. The results of the present study confirmed that the pharmacophore model with four binding sites is essential for antiepileptic activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pyrimidine" title="pyrimidine">pyrimidine</a>, <a href="https://publications.waset.org/abstracts/search?q=semicarbazones" title=" semicarbazones"> semicarbazones</a>, <a href="https://publications.waset.org/abstracts/search?q=anticonvulsant%20activity" title=" anticonvulsant activity"> anticonvulsant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=neurotoxicity" title=" neurotoxicity"> neurotoxicity</a> </p> <a href="https://publications.waset.org/abstracts/40733/novel-pyrimidine-based-semicarbazones-confirmation-of-four-binding-site-pharmacophoric-model-hypothesis-for-antiepileptic-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40733.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">253</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> QSAR, Docking and E-pharmacophore Approach on Novel Series of HDAC Inhibitors with Thiophene Linker as Anticancer Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harish%20Rajak">Harish Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Preeti%20Patel"> Preeti Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> HDAC inhibitors can reactivate gene expression and inhibit the growth and survival of cancer cells. The 3D-QSAR and Pharmacophore modeling studies were performed to identify important pharmacophoric features and correlate 3D-chemical structure with biological activity. The pharmacophore hypotheses were developed using e-pharmacophore script and phase module. Pharmacophore hypothesis represents the 3D arrangement of molecular features necessary for activity. A series of 55 compounds with well-assigned HDAC inhibitory activity was used for 3D-QSAR model development. Best 3D-QSAR model, which is a five PLS factor model with good statistics and predictive ability, acquired Q2 (0.7293), R2 (0.9811) and standard deviation (0.0952). Molecular docking were performed using Histone Deacetylase protein (PDB ID: 1t69) and prepared series of hydroxamic acid based HDAC inhibitors. Docking study of compound 43 show significant binding interactions Ser 276 and oxygen atom of dioxine cap region, Gly 151 and amino group and Asp 267 with carboxyl group of CONHOH, which are essential for anticancer activity. On docking, most of the compounds exhibited better glide score values between -8 to -10.5. We have established structure activity correlation using docking, energetic based pharmacophore modelling, pharmacophore and atom based 3D QSAR model. The results of these studies were further used for the design and testing of new HDAC analogs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Docking" title="Docking">Docking</a>, <a href="https://publications.waset.org/abstracts/search?q=e-pharmacophore" title=" e-pharmacophore"> e-pharmacophore</a>, <a href="https://publications.waset.org/abstracts/search?q=HDACIs" title=" HDACIs"> HDACIs</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=Suberoylanilidehydroxamic%20acid." title=" Suberoylanilidehydroxamic acid."> Suberoylanilidehydroxamic acid.</a> </p> <a href="https://publications.waset.org/abstracts/40734/qsar-docking-and-e-pharmacophore-approach-on-novel-series-of-hdac-inhibitors-with-thiophene-linker-as-anticancer-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40734.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">301</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Docking, Pharmacophore Modeling and 3d QSAR Studies on Some Novel HDAC Inhibitors with Heterocyclic Linker</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harish%20Rajak">Harish Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Preeti%20Patel"> Preeti Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The application of histone deacetylase inhibitors is a well-known strategy in prevention of cancer which shows acceptable preclinical antitumor activity due to its ability of growth inhibition and apoptosis induction of cancer cell. Molecular docking were performed using Histone Deacetylase protein (PDB ID:1t69) and prepared series of hydroxamic acid based HDACIs. On the basis of docking study, it was predicted that compound 1 has significant binding interaction with HDAC protein and three hydrogen bond interactions takes place, which are essential for antitumor activity. On docking, most of the compounds exhibited better glide score values between -8 to -10 which is close to the glide score value of suberoylanilide hydroxamic acid. The pharmacophore hypotheses were developed using e-pharmacophore script and phase module. The 3D-QSAR models provided a good correlation between predicted and actual anticancer activity. Best QSAR model showed Q2 (0.7974), R2 (0.9200) and standard deviation (0.2308). QSAR visualization maps suggest that hydrogen bond acceptor groups at carbonyl group of cap region and hydrophobic groups at ortho, meta, para position of R9 were favorable for HDAC inhibitory activity. We established structure activity correlation using docking, pharmacophore modeling and atom based 3D QSAR model for hydroxamic acid based HDACIs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HDACIs" title="HDACIs">HDACIs</a>, <a href="https://publications.waset.org/abstracts/search?q=QSAR" title=" QSAR"> QSAR</a>, <a href="https://publications.waset.org/abstracts/search?q=e-pharmacophore" title=" e-pharmacophore"> e-pharmacophore</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a>, <a href="https://publications.waset.org/abstracts/search?q=suberoylanilide%20hydroxamic%20acid" title=" suberoylanilide hydroxamic acid"> suberoylanilide hydroxamic acid</a> </p> <a href="https://publications.waset.org/abstracts/40757/docking-pharmacophore-modeling-and-3d-qsar-studies-on-some-novel-hdac-inhibitors-with-heterocyclic-linker" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40757.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">302</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Assessment of Isatin as Surface Recognition Group: Design, Synthesis and Anticancer Evaluation of Hydroxamates as Novel Histone Deacetylase Inhibitors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harish%20Rajak">Harish Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamlesh%20Raghuwanshi"> Kamlesh Raghuwanshi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Histone deacetylase (HDAC) are promising target for cancer treatment. The panobinostat (Farydak; Novartis; approved by USFDA in 2015) and chidamide (Epidaza; Chipscreen Biosciences; approved by China FDA in 2014) are the novel HDAC inhibitors ratified for the treatment of patients with multiple myeloma and peripheral T cell lymphoma, respectively. On the other hand, two other HDAC inhibitors, Vorinostat (SAHA; approved by USFDA in 2006) and Romidepsin (FK228; approved by USFDA in 2009) are already in market for the treatment of cutaneous T-cell lymphoma. Several hydroxamic acid based HDAC inhibitors i.e., belinostat, givinostat, PCI24781 and JNJ26481585 are in clinical trials. HDAC inhibitors consist of three pharmacophoric features - an aromatic cap group, zinc binding group (ZBG) and a linker chain connecting cap group to ZBG. Herein, we report synthesis, characterization and biological evaluation of HDAC inhibitors possessing substituted isatin moiety as cap group which recognize the surface of active enzyme pocket and thiosemicarbazide moiety incorporated as linker group responsible for connecting cap group to ZBG (hydroxamic acid). Several analogues were found to inhibit HDAC and cellular proliferation of Hela cervical cancer cells with GI50 values in the micro molar range. Some of the compounds exhibited promising results in vitro antiproliferative studies. Attempts were also made to establish the structure activity relationship among synthesized HDAC inhibitors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HDAC%20inhibitors" title="HDAC inhibitors">HDAC inhibitors</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxamic%20acid%20derivatives" title=" hydroxamic acid derivatives"> hydroxamic acid derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=isatin%20derivatives" title=" isatin derivatives"> isatin derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=antiproliferative%20%09%09%09activity" title=" antiproliferative activity"> antiproliferative activity</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a> </p> <a href="https://publications.waset.org/abstracts/40759/assessment-of-isatin-as-surface-recognition-group-design-synthesis-and-anticancer-evaluation-of-hydroxamates-as-novel-histone-deacetylase-inhibitors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40759.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">307</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Development Project, Land Acquisition and Rehabilitation: A Study of Navi Mumbai International Airport Project, India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rahul%20Rajak">Rahul Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Archana%20Kumari%20Roy"> Archana Kumari Roy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: Development brings about structural change in the society. It is essential for socio-economic progress of the society, but it also causes pain to the people who are forced to displace from their motherland. Most of the people who are displaced due to development are poor and tribes. Development and displacement are interlinked with each other in the sense development sometimes leads to displacement of people. These studies mainly focus on socio-economic profile of villages and villagers likely to be affected by the Airport Project and they examine the issues of compensation and people’s level of satisfaction. Methodology: The study is based on Descriptive design; it is basically observational and correlation study. Primary data is used in this study. Considering the time and resource constrains, 100 people were interviewed covering socio-economic and demographic diversities from 6 out of 10 affected villages. Due to Navi Mumbai International Airport Project ten villages have to be displaced. Out of ten villages, this study is based on only six villages. These are Ulwe, Ganeshpuri, Targhar Komberbuje, Chincpada and Kopar. All six villages situated in Raigarh district under the Taluka Panvel in Maharashtra. Findings: It is revealed from the survey that there are three main castes of affected villages that are Agri, Koli, and Kradi. Entire village population of migrated person is very negligible. All three caste have main occupation are agricultural and fishing activities. People’s perception revealed that due to the establishment of the airport project, they may have more opportunities and scope of development rather than the adverse effect, but vigorously leave a motherland is psychological effect of the villagers. Research Limitation: This study is based on only six villages, the scenario of the entire ten affected villages is not explained by this research. Practical implication: The scenario of displacement and resettlement signifies more than a mere physical relocation. Compensation is not only hope for villagers, is it only give short time relief. There is a need to evolve institutions to protect and strengthen the right of Individuals. The development induced displacement exposed them to a new reality, the reality of their legality and illegality of stay on the land which belongs to the state. Originality: Mumbai has large population and high industrialized city have put land at the center of any policy implication. This paper demonstrates through the actual picture gathered from the field that how seriously the affected people suffered and are still suffering because of the land acquisition for the Navi Mumbai International Airport Project. The whole picture arise the question which is how long the government can deny the rights to farmers and agricultural laborers and remain unwilling to establish the balance between democracy and development. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=compensation" title="compensation">compensation</a>, <a href="https://publications.waset.org/abstracts/search?q=displacement" title=" displacement"> displacement</a>, <a href="https://publications.waset.org/abstracts/search?q=land%20acquisition" title=" land acquisition"> land acquisition</a>, <a href="https://publications.waset.org/abstracts/search?q=project%20affected%20person%20%28PAPs%29" title=" project affected person (PAPs)"> project affected person (PAPs)</a>, <a href="https://publications.waset.org/abstracts/search?q=rehabilitation" title=" rehabilitation"> rehabilitation</a> </p> <a href="https://publications.waset.org/abstracts/42144/development-project-land-acquisition-and-rehabilitation-a-study-of-navi-mumbai-international-airport-project-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42144.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">317</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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