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class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/connectedlab/"><span class="breadcrumb-link-text-wrap">The Connected Lab</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/connectedlab/manufacturing/"><span class="breadcrumb-link-text-wrap">Manufacturing</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Key Differences Between MES and LIMS in Battery QA</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-2621 post type-post status-publish format-standard has-post-thumbnail category-clean-energy category-manufacturing tag-battery-manufacturing tag-clean-energy tag-lims tag-lims-software tag-manufacturing tag-samplemanager-lims-software entry" aria-label="Key Differences Between MES and LIMS in Battery QA"><header class="entry-header"><h1 class="entry-title">Key Differences Between MES and LIMS in Battery QA</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/johnmcdonald/" title="Posts by John McDonald" rel="author">John McDonald</a> </span> <span class="post-info-date"> 04.05.2023 </span> </header><div class="entry-content"><p>Companies working across the battery manufacture value chain, as well as major automotive OEMs, need to navigate real and constant production challenges and risk. Uppermost is the need to maximise output with consistently high-quality products, economically (i.e. keeping scrap rate at a minimum), and with expedience.</p> <p>And when these challenges keep coming, one way to galvanise quality assurance—to respond strongly with best-in-class processes and defend against manufacturing production risk and the dreaded recall—is to streamline processes, connect systems, and implement continual procedural improvements.</p> <p>Another is to integrate a <a href="https://www.thermofisher.com/uk/en/home/digital-solutions/lab-informatics/lab-information-management-systems-lims.html?cid=E.23CMD.DS111.14470.01">Laboratory Information Management System (LIMS)</a> in the manufacturing production process.</p> <h4>A LIMS is to the laboratory as MES is to production</h4> <p><span class="TextRun SCXW196104631 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW196104631 BCX0">We know that a</span> <span class="NormalTextRun SCXW196104631 BCX0">Manufacturing</span><span class="NormalTextRun SCXW196104631 BCX0"> Execution System is already </span><span class="NormalTextRun SCXW196104631 BCX0">the </span><span class="NormalTextRun SCXW196104631 BCX0">ubiquitous staple</span> <span class="NormalTextRun SCXW196104631 BCX0">of</span><span class="NormalTextRun SCXW196104631 BCX0"> manufacturing </span><span class="NormalTextRun SCXW196104631 BCX0">and process </span><span class="NormalTextRun SCXW196104631 BCX0">industr</span><span class="NormalTextRun SCXW196104631 BCX0">ies. </span><span class="NormalTextRun SCXW196104631 BCX0">Indeed,</span><span class="NormalTextRun SCXW196104631 BCX0"> across the </span><span class="NormalTextRun SCXW196104631 BCX0">battery</span><span class="NormalTextRun SCXW196104631 BCX0"> industry, </span><span class="NormalTextRun SCXW196104631 BCX0">an </span><span class="NormalTextRun SCXW196104631 BCX0">MES</span><span class="NormalTextRun SCXW196104631 BCX0">, </span><span class="NormalTextRun SCXW196104631 BCX0">coupled</span><span class="NormalTextRun SCXW196104631 BCX0"> with a QM module</span><span class="NormalTextRun SCXW196104631 BCX0">,</span><span class="NormalTextRun SCXW196104631 BCX0"> is</span> <span class="NormalTextRun SCXW196104631 BCX0">used to act as a LIMS</span><span class="NormalTextRun SCXW196104631 BCX0">, often in place of a LIMS.</span></span><span class="TextRun SCXW196104631 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW196104631 BCX0"> </span></span><span class="EOP SCXW196104631 BCX0" data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><img decoding="async" class="alignnone wp-image-2622 size-large" src="https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-iStock-1018210700-1024x594.jpg" alt="LIMS for b" width="760" height="441" srcset="https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-iStock-1018210700-1024x594.jpg 1024w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-iStock-1018210700-300x174.jpg 300w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-iStock-1018210700-768x445.jpg 768w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-iStock-1018210700-1536x891.jpg 1536w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-iStock-1018210700-2048x1188.jpg 2048w" sizes="(max-width: 760px) 100vw, 760px" /></p> <hr /> <blockquote> <p style="text-align: left"><strong><i class="fas fa-quote-left " ></i> According to Transport & Environment (T&E)<sup>1 </sup>68% of potential battery production capacity in Europe (1.2 TWh) today is at risk of being delayed, scaled down in terms of planned capacity, or even not realized at all. This is clearly manifested by a larger challenge in the industry about the ability to scale-up battery production and improve approval processes. At a granular level it does signal the status quo will not provide the battery companies across the value chain with competitive edge. In an industry filled with risk, a LIMS solution represents a quality investment.<i class="fas fa-quote-right " ></i></strong></p> <hr /> </blockquote> <p><span data-contrast="none">At its foundation, LIMS software centers on capturing and managing as much information about a sample throughout its lifecycle as is possible. At any one point in the battery production process, a QC Analyst or Laboratory Manager will have to juggle with multiple samples, each at varying points in their lifecycles. Unlike the MES, a LIMS keeps all the laboratory ‘plates spinning’. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">A LIMS captures a variety of meta data as a sample progresses through its lifecycle</span><span data-contrast="none">. This includes the receipt of the sample (and associated customer information), tracking and scheduling through its assigned workflow, and any quality control processing. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">As a matter of course, the LIMS will also capture calibration data for any equipment used, or the location, storage and expiration of any reagents used during testing. It also captures the qualifications of the analyst who performed the testing, and importantly the compliance inspection and approval of the sample for reporting or further analysis. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">Besides managing the scheduling of tests, censoring of instrument calibration and preventative maintenance, and the management of stock including standards and reagents, the LIMS is also used to automatically check results against set specifications. This means a LIMS can handle the review, approval, and reporting on, and distribution of, results of tests performed against the sample. The MES cannot achieve this.</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">These are the base functions that define any LIMS. In stark contrast, the same rich laboratory data is not captured by the MES. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">The MES’s function is to survey the management of the production process. This will typically include gathering data on production scheduling, the dispatch and execution of production orders, the production performance (including work in progress, status of equipment, material lot information, effectiveness of equipment), as well as production track and trace. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">The measurement of production, and the way the battery goes through the production value chain, is evidently then not the same measurement of the materiality—and therein its traceability—that comprises the battery, and ultimately affects the quality of its readiness to comply, to go to, and to stay in market. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">From an international standards perspective i.e. ANSI/ISA-95, these two functional systems are also not considered to be the same. In the context of battery manufacturing standards, an MES simply will not cover sample quality, sample integrity or sample compliance (e.g. <a href="https://www.thermofisher.com/uk/en/home/global/forms/digital-solutions/ISO-17025-testing-ebook.html?cid=E.23CMD.DS111.14470.01" target="_blank" rel="noopener">ISO 17025</a>).</span></p> <p><img decoding="async" class="alignnone wp-image-2629 size-large" src="https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-AdobeStock_448338635-1024x549.jpeg" alt="LIMS for battery manufacture and production " width="760" height="407" srcset="https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-AdobeStock_448338635-1024x549.jpeg 1024w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-AdobeStock_448338635-300x161.jpeg 300w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-AdobeStock_448338635-768x412.jpeg 768w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-AdobeStock_448338635-1536x823.jpeg 1536w, https://www.thermofisher.com/blog/connectedlab/wp-content/uploads/sites/14/2023/04/MES-Battery-blog-AdobeStock_448338635-2048x1097.jpeg 2048w" sizes="(max-width: 760px) 100vw, 760px" /></p> <h4>Capabilities of LIMS are evolving</h4> <p><span data-contrast="none">Customers are demanding more from technology, so battery technology is evolving. At the same time LIMS are also advancing and represent a very capable software solution. </span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <p><span data-contrast="none">LIMS has numerous additional functions, which again trump the MES. It can manage and assign chain of custody, and importantly show an audit trail for the traceability of a sample. It can process and convert data into certain document formats, as well as create and schedule reports in a specific format. It can read and extract information from a barcode. It can handle CRM and demographic information for client communications; and like an MES, it can also organize work schedules, workload assignments, employee demographic information, training needs and financial information.</span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":259,"469777462":[66],"469777927":[0],"469777928":[8]}"> </span></p> <h4><b><span data-contrast="none">Missing in action</span></b></h4> <p><span class="TextRun SCXW86887215 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW86887215 BCX0">There is a </span><span class="NormalTextRun SCXW86887215 BCX0">sway of </span><span class="NormalTextRun SCXW86887215 BCX0">elemental </span><span class="NormalTextRun SCXW86887215 BCX0">functionality missing in the MES</span><span class="NormalTextRun SCXW86887215 BCX0">.</span> <span class="NormalTextRun SCXW86887215 BCX0">For example, an </span><span class="NormalTextRun SCXW86887215 BCX0">MES is unable</span> <span class="NormalTextRun SCXW86887215 BCX0">to </span><span class="NormalTextRun SCXW86887215 BCX0">manage sample work instruction and test method integration</span><span class="NormalTextRun SCXW86887215 BCX0">;</span><span class="NormalTextRun SCXW86887215 BCX0"> to create multi-level rounding rules compliant with test methods</span><span class="NormalTextRun SCXW86887215 BCX0">;</span><span class="NormalTextRun SCXW86887215 BCX0"> it struggles with standardized instrument integration</span><span class="NormalTextRun SCXW86887215 BCX0">;</span> <span class="NormalTextRun SCXW86887215 BCX0">it </span><span class="NormalTextRun SCXW86887215 BCX0">typically</span><span class="NormalTextRun SCXW86887215 BCX0"> doesn’t include an easy-to-use scheduler to capture the Service Level Agreement be</span><span class="NormalTextRun SCXW86887215 BCX0">tween the laboratory and the customer</span><span class="NormalTextRun SCXW86887215 BCX0">;</span><span class="NormalTextRun SCXW86887215 BCX0"> it doesn’t </span><span class="NormalTextRun SCXW86887215 BCX0">provide</span> </span><a class="Hyperlink SCXW86887215 BCX0" href="https://www.thermofisher.com/uk/en/home/digital-solutions/lab-informatics/data-analytics-solution.html?cid=E.23CMD.DS111.14470.01" target="_blank" rel="noreferrer noopener"><span class="TextRun Underlined SCXW86887215 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW86887215 BCX0" data-ccp-charstyle="Hyperlink">data dashboards with standardized efficiency tools</span></span></a><span class="TextRun SCXW86887215 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW86887215 BCX0"> (</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW86887215 BCX0">such</span><span class="NormalTextRun SCXW86887215 BCX0"> as </span><span class="NormalTextRun SCXW86887215 BCX0">time per test, </span><span class="NormalTextRun SCXW86887215 BCX0">response</span><span class="NormalTextRun SCXW86887215 BCX0">-times</span><span class="NormalTextRun SCXW86887215 BCX0">, etc.)</span><span class="NormalTextRun SCXW86887215 BCX0">;</span><span class="NormalTextRun SCXW86887215 BCX0"> it cannot cope with ad-hoc samples </span><span class="NormalTextRun SCXW86887215 BCX0">and </span><span class="NormalTextRun SCXW86887215 BCX0">non-routine</span> <span class="NormalTextRun SCXW86887215 BCX0">laboratory</span><span class="NormalTextRun SCXW86887215 BCX0"> projects</span><span class="NormalTextRun SCXW86887215 BCX0">;</span><span class="NormalTextRun SCXW86887215 BCX0"> it cannot oversee instrument performance (</span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW86887215 BCX0">i.e.</span><span class="NormalTextRun SCXW86887215 BCX0"> when to calibrate</span><span class="NormalTextRun SCXW86887215 BCX0">, when to perform maintenance, etc); it cannot </span><span class="NormalTextRun SCXW86887215 BCX0">s</span><span class="NormalTextRun SCXW86887215 BCX0">upply</span><span class="NormalTextRun SCXW86887215 BCX0"> S</span><span class="NormalTextRun SCXW86887215 BCX0">tatistical </span><span class="NormalTextRun SCXW86887215 BCX0">Q</span><span class="NormalTextRun SCXW86887215 BCX0">uality </span><span class="NormalTextRun SCXW86887215 BCX0">C</span><span class="NormalTextRun SCXW86887215 BCX0">ontrol</span><span class="NormalTextRun SCXW86887215 BCX0">,</span><span class="NormalTextRun SCXW86887215 BCX0"> or</span><span class="NormalTextRun SCXW86887215 BCX0"><a href="https://www.thermofisher.com/blog/connectedlab/unleashing-the-power-of-analytical-quality-control-in-the-oil-and-gas-sector/"> Analytical Quality Control</a> charting to meet ASTM-D6299 for laboratory processes.</span><span class="NormalTextRun SCXW86887215 BCX0"> Nor does</span> <span class="NormalTextRun SCXW86887215 BCX0">it </span><span class="NormalTextRun SCXW86887215 BCX0">meet the </span><span class="NormalTextRun SCXW86887215 BCX0">regulatory </span><span class="NormalTextRun SCXW86887215 BCX0">requirements of ISO</span> <span class="NormalTextRun SCXW86887215 BCX0">17025</span><span class="NormalTextRun SCXW86887215 BCX0">, </span><span class="NormalTextRun SCXW86887215 BCX0">or</span><span class="NormalTextRun SCXW86887215 BCX0"> the Health, Safety and Environmental requirements for laboratory reagents and materials.</span><span class="NormalTextRun SCXW86887215 BCX0"> </span></span><span class="EOP SCXW86887215 BCX0" data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":240}"> </span></p> <h4><span class="TextRun SCXW140095747 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW140095747 BCX0" data-ccp-parastyle="heading 3">Plug the gaps with a LIMS</span></span><span class="EOP SCXW140095747 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335559738":0,"335559739":0,"335559740":240}"> </span></h4> <p><span class="TextRun SCXW129829101 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">As proven technology</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">,</span> </span><a class="Hyperlink SCXW129829101 BCX0" href="https://www.thermofisher.com/uk/en/home/digital-solutions/lab-informatics/lims-advanced-battery-manufacture.html?cid=E.23CMD.DS111.14470.01" target="_blank" rel="noreferrer noopener"><span class="TextRun Underlined SCXW129829101 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-charstyle="Hyperlink">Thermo Scientific™ SampleManager™ LIMS software</span></span></a><span class="TextRun SCXW129829101 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3"> plugs the gaps of the </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW129829101 BCX0" data-ccp-parastyle="heading 3">MES,</span> <span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW129829101 BCX0" data-ccp-parastyle="heading 3">and</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3"> drives quality control through all stages of production. It’s designed to improve lab efficiency, speed turnaround time, and enable compliance </span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">to industry</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3"> standards</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">, so</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3"> bring</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">ing</span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3"> numerous benefits to companies competing in the extraction of and processing of raw materials, cell manufacture, </span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">or the </span><span class="NormalTextRun SCXW129829101 BCX0" data-ccp-parastyle="heading 3">second life and recycling stages of the battery manufacture value chain. </span></span><span class="EOP SCXW129829101 BCX0" data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335559738":0,"335559739":0,"335559740":240}"> </span></p> <h4><b><span data-contrast="none">Integrating LIMS with an MES</span></b></h4> <p><span data-contrast="none">Furthermore, a LIMS can be </span><span data-contrast="none">easily connected</span><span data-contrast="none"> to the majority of lab instrumentation. Importantly, (and battery manufacturers please take note) the LIMS can also be </span><a href="https://www.thermofisher.com/uk/en/home/digital-solutions/lab-informatics/integration.html?cid=E.23CMD.DS111.14470.01"><span data-contrast="none">integrated with other systems</span></a><span data-contrast="none"> such as an MES, and an ERP: the integration of a LIMS in the battery manufacturing process means the </span><a href="https://www.thermofisher.com/blog/connectedlab/could-lims-integration-make-battery-manufacturing-workflows-more-efficient-and-cost-competitive/?cid=E.23CMD.DS111.14470.01"><span data-contrast="none">production is efficient</span></a><span data-contrast="none"> and interminably strengthened. And because of its ability to integrate, paper processes are removed, eliminating the need for the analyst to manually record data—a cumbersome process—and therefore potential for human error. Quality is also reassuringly central in the LIMS solution. Again, from the perspective of a company operating in the battery industry value chain, this enables a better standardization between the company’s different sites, as LIMS will indirectly standardize working practises.</span><span data-ccp-props="{"134233117":false,"134233118":false,"201341983":0,"335559738":0,"335559739":0,"335559740":240}"> </span></p> <p><span data-contrast="none">And when working in sync with an MES, to feed critical data back into production, </span><a href="https://www.thermofisher.com/blog/connectedlab/quality-management-in-battery-manufacturing-lims-drive-efficiency-and-data-integrity/?cid=E.23CMD.DS111.14470.01"><span data-contrast="none">a LIMS keeps your quality control one step beyond</span></a><span data-contrast="none">, driving consistency and charging continuous product improvements.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <p><span data-contrast="none">Learn more about making a Laboratory Information Management System an essential component of the battery manufacturing QA/QC lab here: </span><a href="https://www.thermofisher.com/us/en/home/digital-solutions/lab-informatics/lims-advanced-battery-manufacture.html?cid=E.23CMD.DS111.14470.01"><span data-contrast="none">www.thermofisher.com/batterylims</span></a><span data-contrast="none">.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></p> <h4>References</h4> <ol> <li><a href="https://www.transportenvironment.org/discover/two-thirds-of-european-battery-production-at-risk-analysis/" target="_blank" rel="noopener">Two-thirds of European battery production at risk – analysis – Transport and Environment </a></li> </ol> <p> </p> <aside class="mashsb-container mashsb-main "><div class="mashsb_above_buttons">Share this article </div><div class="mashsb-box"><div class="mashsb-buttons"><a class="mashicon-facebook mash-large mashsb-noshadow" 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