CINXE.COM

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta name="google-site-verification" content="S9ahhSTJNJrGXH8CLzN9O29lYE5sbaFyCLkdCXHU24U" />  <meta name="google-site-verification" content="UqdiAS4yhbCtENKZBNgS0WPiAcMQFShAEjOhMChYmdM" /> <title> A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products - CaltechTHESIS</title>  <script> var _paq = window._paq = window._paq || []; /* tracker methods like "setCustomDimension" should be called before "trackPageView" */ _paq.push(['trackPageView']); _paq.push(['enableLinkTracking']); (function() { var u="https://caltechlibrary.matomo.cloud/"; _paq.push(['setTrackerUrl', u+'matomo.php']); _paq.push(['setSiteId', '3']); var d=document, g=d.createElement('script'), s=d.getElementsByTagName('script')[0]; g.async=true; g.src='//cdn.matomo.cloud/caltechlibrary.matomo.cloud/matomo.js'; s.parentNode.insertBefore(g,s); })(); </script>  <script src="https://thesis.library.caltech.edu/javascript/auto.js" type="text/javascript"></script> <style type="text/css" media="screen">@import url(https://thesis.library.caltech.edu/style/auto.css);</style> <style type="text/css" media="print">@import url(https://thesis.library.caltech.edu/style/print.css);</style> <link rel="icon" href="/favicon.ico" type="image/x-icon" /> <link rel="shortcut icon" href="/favicon.ico" type="image/x-icon" /> <link rel="Top" href="https://thesis.library.caltech.edu/" /> <link rel="Search" href="https://thesis.library.caltech.edu/cgi/search" /> <meta name="eprints.eprintid" content="7215" /> <meta name="eprints.rev_number" content="35" /> <meta name="eprints.eprint_status" content="archive" /> <meta name="eprints.userid" content="9599" /> <meta name="eprints.dir" content="disk0/00/00/72/15" /> <meta name="eprints.datestamp" content="2013-11-04 20:32:21" /> <meta name="eprints.lastmod" content="2023-11-08 00:39:09" /> <meta name="eprints.status_changed" content="2015-11-12 22:53:29" /> <meta name="eprints.type" content="thesis" /> <meta name="eprints.metadata_visibility" content="show" /> <meta name="eprints.creators_name" content="Nelson, Hosea Martin" /> <meta name="eprints.creators_id" content="Nelson-Hosea-Martin" /> <meta name="eprints.creators_email" content="hoseanelson@gmail.com" /> <meta name="eprints.creators_show_email" content="NO" /> <meta name="eprints.title" content="A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products" /> <meta name="eprints.ispublished" content="unpub" /> <meta name="eprints.divisions" content="div_chem" /> <meta name="eprints.full_text_status" content="public" /> <meta name="eprints.keywords" content="Basiliolide, Transtaganolide, Ireland–Claisen, Diels–Alder, Natural Products" /> <meta name="eprints.suggestions" content="Withheld until Oct. 7 2015. Released 11/12/2015" /> <meta name="eprints.abstract" content="<p>Herein are described the first total syntheses of several members of the transtaganolide and basiliolide natural product family. A general strategy, hinging upon the use of a biomimetic Ireland–Claisen rearrangement/Diels–Alder cycloaddition cascade, was developed. It allowed for the rapid assembly of the most structurally complex, and biologically active members of the family.</p> <p>A brief introduction that surveys the use of the pyrone Diels–Alder cycloaddition in total synthesis precedes details of our synthetic efforts. The diversity of structural motifs accessible through this reaction manifold is described through literature examples.</p> <p>The account of our experimental work begins with details of extensive model studies. First, a simple system was prepared which probed the ability to construct basiliolide B via an intramolecular pyrone Diels–Alder reaction. It was demonstrated that the sterically congested core could be constructed in a highly diastereoselective fashion using this technology. Second, a simple prenylated pyrone was constructed, and shown to undergo a facile Ireland–Claisen rearrangement under a variety of conditions. Subsequently, the utilization of these two methods within a cascade allowed for the rapid construction of racemic transtaganolide C, transtaganolide D, basiliolide B, and epi-8-basiliolide B. Furthermore, a novel Pd-catalyzed [5+2] annulation technology is utilized to construct the venerable, carboxy-ketene-acetal containing C-ring present in most of the metabolites.</p> <p>Integration of asymmetry into our general strategy is also described. Utilization of a chiral silane directing group allowed for the successful and rare application of an enantioselective Ireland–Claisen rearrangement, culminating in the total syntheses of (+)- transtaganolide C, (–)-transtaganolide D, (+)-transtaganolide B, and (–)-transtaganolide A. Furthermore, the impact of this work on existing biosynthetic hypotheses is discussed.</p> " /> <meta name="eprints.date" content="2013" /> <meta name="eprints.date_type" content="degree" /> <meta name="eprints.id_number" content="CaltechTHESIS:09282012-144447840" /> <meta name="eprints.institution" content="California Institute of Technology" /> <meta name="eprints.thesis_type" content="phd" /> <meta name="eprints.refereed" content="FALSE" /> <meta name="eprints.official_url" content="https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840" /> <meta name="eprints.rights" content="No commercial reproduction, distribution, display or performance rights in this work are provided." /> <meta name="eprints.doi" content="10.7907/09DW-P586" /> <meta name="eprints.collection" content="CaltechTHESIS" /> <meta name="eprints.thesis_advisor_name" content="Stoltz, Brian M." /> <meta name="eprints.thesis_advisor_id" content="Stoltz-B-M" /> <meta name="eprints.thesis_advisor_role" content="advisor" /> <meta name="eprints.thesis_advisor_email" content="stoltz@caltech.edu" /> <meta name="eprints.thesis_committee_name" content="Dervan, Peter B." /> <meta name="eprints.thesis_committee_name" content="Grubbs, Robert H." /> <meta name="eprints.thesis_committee_name" content="Stoltz, Brian M." /> <meta name="eprints.thesis_committee_name" content="Reisman, Sarah E." /> <meta name="eprints.thesis_committee_id" content="Dervan-P-B" /> <meta name="eprints.thesis_committee_id" content="Grubbs-R-H" /> <meta name="eprints.thesis_committee_id" content="Stoltz-B-M" /> <meta name="eprints.thesis_committee_id" content="Reisman-S-E" /> <meta name="eprints.thesis_committee_role" content="chair" /> <meta name="eprints.thesis_committee_role" content="member" /> <meta name="eprints.thesis_committee_role" content="member" /> <meta name="eprints.thesis_committee_role" content="member" /> <meta name="eprints.thesis_committee_email" content="dervan@caltech.edu" /> <meta name="eprints.thesis_committee_email" content="rhg@caltech.edu" /> <meta name="eprints.thesis_committee_email" content="stoltz@caltech.edu" /> <meta name="eprints.thesis_committee_email" content="reisman@caltech.edu" /> <meta name="eprints.thesis_degree" content="PHD" /> <meta name="eprints.thesis_degree_grantor" content="California Institute of Technology" /> <meta name="eprints.thesis_defense_date" content="2012-09-20" /> <meta name="eprints.reviewer" content="Kathy Johnson" /> <meta name="eprints.review_status" content="approved" /> <meta name="eprints.option_major" content="chemistry" /> <meta name="eprints.copyright_statement" content="Author's Rights Authorization: I hereby certify that, if appropriate, I have obtained a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted here is the same as that approved by my advisory committee. I hereby grant to California Institute of Technology or its agents the non-exclusive license to archive and make accessible, under the conditions specified under "Thesis Availability" in this submission, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation, or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report." /> <meta name="eprints.gradofc_approval_date" content="2012-10-24" /> <meta name="eprints.citation" content=" Nelson, Hosea Martin (2013) A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/09DW-P586. https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840 <https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840> " /> <meta name="eprints.document_url" content="https://thesis.library.caltech.edu/7215/1/Nelson-Hosea-Martin-2013.pdf" /> <link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /> <meta name="DC.relation" content="https://thesis.library.caltech.edu/7215/" /> <meta name="DC.title" content="A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products" /> <meta name="DC.creator" content="Nelson, Hosea Martin" /> <meta name="DC.description" content="<p>Herein are described the first total syntheses of several members of the transtaganolide and basiliolide natural product family. A general strategy, hinging upon the use of a biomimetic Ireland–Claisen rearrangement/Diels–Alder cycloaddition cascade, was developed. It allowed for the rapid assembly of the most structurally complex, and biologically active members of the family.</p> <p>A brief introduction that surveys the use of the pyrone Diels–Alder cycloaddition in total synthesis precedes details of our synthetic efforts. The diversity of structural motifs accessible through this reaction manifold is described through literature examples.</p> <p>The account of our experimental work begins with details of extensive model studies. First, a simple system was prepared which probed the ability to construct basiliolide B via an intramolecular pyrone Diels–Alder reaction. It was demonstrated that the sterically congested core could be constructed in a highly diastereoselective fashion using this technology. Second, a simple prenylated pyrone was constructed, and shown to undergo a facile Ireland–Claisen rearrangement under a variety of conditions. Subsequently, the utilization of these two methods within a cascade allowed for the rapid construction of racemic transtaganolide C, transtaganolide D, basiliolide B, and epi-8-basiliolide B. Furthermore, a novel Pd-catalyzed [5+2] annulation technology is utilized to construct the venerable, carboxy-ketene-acetal containing C-ring present in most of the metabolites.</p> <p>Integration of asymmetry into our general strategy is also described. Utilization of a chiral silane directing group allowed for the successful and rare application of an enantioselective Ireland–Claisen rearrangement, culminating in the total syntheses of (+)- transtaganolide C, (–)-transtaganolide D, (+)-transtaganolide B, and (–)-transtaganolide A. Furthermore, the impact of this work on existing biosynthetic hypotheses is discussed.</p> " /> <meta name="DC.date" content="2013" /> <meta name="DC.type" content="Thesis" /> <meta name="DC.type" content="NonPeerReviewed" /> <meta name="DC.format" content="application/pdf" /> <meta name="DC.language" content="en" /> <meta name="DC.rights" content="other" /> <meta name="DC.identifier" content="https://thesis.library.caltech.edu/7215/1/Nelson-Hosea-Martin-2013.pdf" /> <meta name="DC.identifier" content=" Nelson, Hosea Martin (2013) A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/09DW-P586. https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840 <https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840> " /> <meta name="DC.relation" content="https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840" /> <meta name="DC.relation" content="CaltechTHESIS:09282012-144447840" /> <meta name="DC.relation" content="10.7907/09DW-P586" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/Atom/caltechthesis-eprint-7215.xml" type="application/atom+xml;charset=utf-8" title="Atom" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/RDFN3/caltechthesis-eprint-7215.n3" type="text/n3" title="RDF+N3" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/Refer/caltechthesis-eprint-7215.refer" type="text/plain" title="Refer" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/COinS/caltechthesis-eprint-7215.txt" type="text/plain; charset=utf-8" title="OpenURL ContextObject in Span" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/ETD_MS/caltechthesis-eprint-7215.xml" type="text/xml; charset=utf-8" title="ETD_MS" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/DC/caltechthesis-eprint-7215.txt" type="text/plain; charset=utf-8" title="Dublin Core" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/LocalEndNote/caltechthesis-eprint-7215.enw" type="text/plain; charset=utf-8" title="EndNote" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/MODS/caltechthesis-eprint-7215.xml" type="text/xml; charset=utf-8" title="MODS" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/CSV/caltechthesis-eprint-7215.csv" type="text/csv; charset=utf-8" title="Multiline CSV" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/LocalBibTeX/caltechthesis-eprint-7215.bib" type="text/plain" title="BibTeX" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/ContextObject/caltechthesis-eprint-7215.xml" type="text/xml; charset=utf-8" title="OpenURL ContextObject" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/XML/caltechthesis-eprint-7215.xml" type="application/vnd.eprints.data+xml; charset=utf-8" title="EP3 XML" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/Text/caltechthesis-eprint-7215.txt" type="text/plain; charset=utf-8" title="ASCII Citation" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/HTML/caltechthesis-eprint-7215.html" type="text/html; charset=utf-8" title="HTML Citation" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/RDFNT/caltechthesis-eprint-7215.nt" type="text/plain" title="RDF+N-Triples" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/UMI/caltechthesis-eprint-7215.xml" type="text/xml; charset=utf-8" title="UMI" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/Simple/caltechthesis-eprint-7215.txt" type="text/plain; charset=utf-8" title="Simple Metadata" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/DIDL/caltechthesis-eprint-7215.xml" type="text/xml; charset=utf-8" title="MPEG-21 DIDL" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/JSON/caltechthesis-eprint-7215.js" type="application/json; charset=utf-8" title="JSON" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/RDFXML/caltechthesis-eprint-7215.rdf" type="application/rdf+xml" title="RDF+XML" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/RIS/caltechthesis-eprint-7215.ris" type="text/plain" title="Reference Manager" /> <link rel="alternate" href="https://thesis.library.caltech.edu/cgi/export/eprint/7215/METS/caltechthesis-eprint-7215.xml" type="text/xml; charset=utf-8" title="METS" /> <link rel="Top" href="https://thesis.library.caltech.edu/" /> <link rel="Sword" href="https://thesis.library.caltech.edu/sword-app/servicedocument" /> <link rel="SwordDeposit" href="https://thesis.library.caltech.edu/id/contents" /> <link rel="Search" type="text/html" href="http://thesis.library.caltech.edu/cgi/search" /> <link rel="Search" type="application/opensearchdescription+xml" href="http://thesis.library.caltech.edu/cgi/opensearchdescription" title="CaltechTHESIS" /> <script type="text/javascript" src="https://www.google.com/jsapi"></script><script type="text/javascript"> // <![CDATA[ google.load("visualization", "1", {packages:["corechart", "geochart"]}); // ]]></script><script type="text/javascript"> // <![CDATA[ var eprints_http_root = "https://thesis.library.caltech.edu"; var eprints_http_cgiroot = "https://thesis.library.caltech.edu/cgi"; var eprints_oai_archive_id = "thesis.library.caltech.edu"; var eprints_logged_in = false; // ]]></script> <style type="text/css">.ep_logged_in { display: none }</style> <link rel="stylesheet" type="text/css" href="/style/auto-3.3.16.css" /> <script type="text/javascript" src="/javascript/auto-3.3.16.js"></script>  <meta name="Generator" content="EPrints 3.3.16" /> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta http-equiv="Content-Language" content="en" /> </head> <body bgcolor="#ffffff" text="#000000"> <div class="ep_noprint"><noscript><style type="text/css">@import url(https://thesis.library.caltech.edu/style/nojs.css);</style></noscript></div> <div class="ep_tm_header ep_noprint"> <div class="ep_tm_sponsor_logo"><a href="https://library.caltech.edu"><img alt="CLS Logo" src="/images/new_cls_logo_60.gif" /></a></div> <div class="ep_tm_logo"><a href="https://libguides.caltech.edu/CODA"><img alt="CODA Logo" src="/images/codalogo.jpg" /></a></div> <div><a class="ep_tm_archivetitle" href="https://thesis.library.caltech.edu/">CaltechTHESIS</a></div> <div><a class="ep_tm_archive_subtitle" href="https://library.caltech.edu"> A Caltech Library Service</a></div> <ul class="ep_tm_menu"><li><a href="https://thesis.library.caltech.edu/">Home</a></li> <li><a href="https://thesis.library.caltech.edu/information.html">About</a></li> <li><a href="https://thesis.library.caltech.edu/browseviews.html">Browse</a></li> <li><a href="https://thesis.library.caltech.edu/cgi/search/simple">Simple Search</a></li> <li><a href="https://thesis.library.caltech.edu/cgi/search/advsearch">Advanced Search</a></li> <li><a href="https://thesis.library.caltech.edu/cgi/users/home">Deposit an Item</a></li>  <li><a href="https://libguides.caltech.edu/theses" target="_blank">Instructions for Students</a></li> <li><a href="mailto:library@caltech.edu" target="_blank">Contact Us</a></li> </ul> <table class="ep_tm_searchbar" border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td align="left"><a href="https://thesis.library.caltech.edu/cgi/users/home">Login</a></td> <td align="right" style="white-space: nowrap"> <form method="get" accept-charset="utf-8" action="https://thesis.library.caltech.edu/cgi/search" style="display:inline"> <input class="ep_tm_searchbarbox" accept-charset="utf-8" size="20" type="text" name="q" /> <input class="ep_tm_searchbarbutton" value="Search" type="submit" name="_action_search" /> <input type="hidden" name="_order" value="bytitle" /> <input type="hidden" name="basic_srchtype" value="ALL" /> <input type="hidden" name="_satisfyall" value="ALL" /> </form> </td> </tr> </table> </div> <div align="center"> <table width="720" class="ep_tm_main"><tr><td align="left"> <h1 class="ep_tm_pagetitle"> A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products </h1> <div class="ep_summary_content"><div class="ep_summary_content_left"></div><div class="ep_summary_content_right"></div><div class="ep_summary_content_top"></div><div class="ep_summary_content_main"><div class="ep_block"><h2>Citation</h2><p class="ep_block" style="margin-bottom: 1em"> <span class="person_name">Nelson, Hosea Martin</span> (2013) <em>A Unified Synthetic Approach to the Transtaganolide and Basiliolide Natural Products.</em> Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/09DW-P586. <a href="https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840">https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840</a> </p></div><div class="ep_block"><h2>Abstract</h2><p style="text-align: left; margin: 1em auto 0em auto"><p style="text-align: left; margin: 1em auto 0em auto">Herein are described the first total syntheses of several members of the transtaganolide and basiliolide natural product family. A general strategy, hinging upon the use of a biomimetic Ireland–Claisen rearrangement/Diels–Alder cycloaddition cascade, was developed. It allowed for the rapid assembly of the most structurally complex, and biologically active members of the family.</p> <p style="text-align: left; margin: 1em auto 0em auto">A brief introduction that surveys the use of the pyrone Diels–Alder cycloaddition in total synthesis precedes details of our synthetic efforts. The diversity of structural motifs accessible through this reaction manifold is described through literature examples.</p> <p style="text-align: left; margin: 1em auto 0em auto">The account of our experimental work begins with details of extensive model studies. First, a simple system was prepared which probed the ability to construct basiliolide B via an intramolecular pyrone Diels–Alder reaction. It was demonstrated that the sterically congested core could be constructed in a highly diastereoselective fashion using this technology. Second, a simple prenylated pyrone was constructed, and shown to undergo a facile Ireland–Claisen rearrangement under a variety of conditions. Subsequently, the utilization of these two methods within a cascade allowed for the rapid construction of racemic transtaganolide C, transtaganolide D, basiliolide B, and epi-8-basiliolide B. Furthermore, a novel Pd-catalyzed [5+2] annulation technology is utilized to construct the venerable, carboxy-ketene-acetal containing C-ring present in most of the metabolites.</p> <p style="text-align: left; margin: 1em auto 0em auto">Integration of asymmetry into our general strategy is also described. Utilization of a chiral silane directing group allowed for the successful and rare application of an enantioselective Ireland–Claisen rearrangement, culminating in the total syntheses of (+)- transtaganolide C, (–)-transtaganolide D, (+)-transtaganolide B, and (–)-transtaganolide A. Furthermore, the impact of this work on existing biosynthetic hypotheses is discussed.</p> </p></div><table class="ep_block" style="margin-bottom: 1em" border="0" cellpadding="3"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Thesis (Dissertation (Ph.D.))</td></tr><tr><th valign="top" class="ep_row">Subject Keywords:</th><td valign="top" class="ep_row">Basiliolide, Transtaganolide, Ireland–Claisen, Diels–Alder, Natural Products</td></tr><tr><th valign="top" class="ep_row">Degree Grantor:</th><td valign="top" class="ep_row">California Institute of Technology</td></tr><tr><th valign="top" class="ep_row">Division:</th><td valign="top" class="ep_row">Chemistry and Chemical Engineering</td></tr><tr><th valign="top" class="ep_row">Major Option:</th><td valign="top" class="ep_row">Chemistry</td></tr><tr><th valign="top" class="ep_row">Thesis Availability:</th><td valign="top" class="ep_row">Public (worldwide access)</td></tr><tr><th valign="top" class="ep_row">Research Advisor(s):</th><td valign="top" class="ep_row"><ul><li><span class="person_name">Stoltz, Brian M.</span></li></ul></td></tr><tr><th valign="top" class="ep_row">Thesis Committee:</th><td valign="top" class="ep_row"><ul><li><span class="person_name">Dervan, Peter B. (chair)</span></li><li><span class="person_name">Grubbs, Robert H.</span></li><li><span class="person_name">Stoltz, Brian M.</span></li><li><span class="person_name">Reisman, Sarah E.</span></li></ul></td></tr><tr><th valign="top" class="ep_row">Defense Date:</th><td valign="top" class="ep_row">20 September 2012</td></tr><tr><th valign="top" class="ep_row">Record Number:</th><td valign="top" class="ep_row">CaltechTHESIS:09282012-144447840</td></tr><tr><th valign="top" class="ep_row">Persistent URL:</th><td valign="top" class="ep_row"><a href="https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840">https://resolver.caltech.edu/CaltechTHESIS:09282012-144447840</a></td></tr><tr><th valign="top" class="ep_row">DOI:</th><td valign="top" class="ep_row">10.7907/09DW-P586</td></tr><tr><th valign="top" class="ep_row">Default Usage Policy:</th><td valign="top" class="ep_row">No commercial reproduction, distribution, display or performance rights in this work are provided.</td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">7215</td></tr><tr><th valign="top" class="ep_row">Collection:</th><td valign="top" class="ep_row">CaltechTHESIS</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"> <span class="ep_name_citation"><span class="person_name">Hosea Nelson</span></span> </td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">04 Nov 2013 20:32</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">08 Nov 2023 00:39</td></tr></table><p class="ep_block" style="margin-bottom: 1em"></p><div class="ep_block"><h2>Thesis Files</h2><p style="text-align: left; margin: 1em auto 0em auto"></p></div><table class="ep_block" style="margin-bottom: 1em"><tr><td valign="top" style="text-align:center"><a class="ep_document_link" href="https://thesis.library.caltech.edu/7215/1/Nelson-Hosea-Martin-2013.pdf" onmouseover="EPJS_ShowPreview( event, 'doc_preview_38467' );" onmouseout="EPJS_HidePreview( event, 'doc_preview_38467' );"><img class="ep_doc_icon" alt="[img]" src="https://thesis.library.caltech.edu/7215/1.hassmallThumbnailVersion/Nelson-Hosea-Martin-2013.pdf" border="0" /></a><div id="doc_preview_38467" class="ep_preview"><table><tr><td><img class="ep_preview_image" alt="" src="https://thesis.library.caltech.edu/7215/1.haspreviewThumbnailVersion/Nelson-Hosea-Martin-2013.pdf" border="0" /><div class="ep_preview_title">Preview</div></td></tr></table></div></td><td valign="top">  <span class="ep_document_citation"> <a class="ep_document_link" href="https://thesis.library.caltech.edu/7215/1/Nelson-Hosea-Martin-2013.pdf">PDF</a> - Final Version  <br />See Usage Policy. </span> <br />18MB</td></tr></table><p align="right">Repository Staff Only: <a href="https://thesis.library.caltech.edu/cgi/users/home?screen=EPrint::View&eprintid=7215">item control page</a></p></div><div class="ep_summary_content_bottom"></div><div class="ep_summary_content_after"></div></div> </td></tr></table> </div> <div class="ep_tm_footer ep_noprint"> <hr noshade="noshade" class="ep_ruler" /> <hr class="ep_tm_last" /> <div style="float: right; margin-left: 1em"><a href="https://eprints.org/software/"><img src="/images/eprintslogo.gif" border="0" /></a></div> <div style="font-size: 80%;"> <div>CaltechTHESIS is powered by <em><a href="https://eprints.org/software/">EPrints 3.3</a></em> which is developed by the <a href="https://www.ecs.soton.ac.uk/">School of Electronics and Computer Science</a> at the University of Southampton. <a href="/eprints/">More information and software credits</a>.</div> </div> </div> </body> </html>