CINXE.COM

<!DOCTYPE html> <html lang="en"> <head id="Head1"><meta name="viewport" content="width=device-width, initial-scale=1.0" /><meta http-equiv="X-UA-Compatible" content="IE=edge" /><title> IO Resistance Initiative - Society for Immunotherapy of Cancer (SITC) </title><meta name='audience' content='ALL' /><meta name='rating' content='General' /><meta name='distribution' content='Global, Worldwide' /><meta name='copyright' content='Higher Logic, LLC' /><meta name='content-language' content='EN' /><meta name='referrer' content='strict-origin-when-cross-origin' /><link rel="apple-touch-icon" href="//higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/sitc_log_color_250px.png" /><meta name="apple-itunes-app" content="app-id=1555408470, app-argument=http://www.sitcancer.org/advocacy/access-advocacy-summits-initiatives/resistance"><link rel='SHORTCUT ICON' href='https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC%20CONNECT%20favicon.ico' type='image/ico' /><link href='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/Font-Awesome/6.4.2-pro/css/all.min.css' type='text/css' rel='stylesheet' /><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/themes/prism.min.css" integrity="sha512-tN7Ec6zAFaVSG3TpNAKtk4DOHNpSwKHxxrsiw4GHKESGPs5njn/0sMCUMl2svV4wo4BK/rCP7juYz+zx+l6oeQ==" crossorigin="anonymous" referrerpolicy="no-referrer" /><link href='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/bootstrap/3.4.1/css/bootstrap.min.css' rel='stylesheet' /><link type='text/css' rel='stylesheet' href='https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/Bundles/Desktop_bundle.min.d7804150d2a3d23b0f7bd53234959d21d94a14f1.hash.css'/><link href='https://ajax.googleapis.com/ajax/libs/jqueryui/1.10.1/themes/base/jquery-ui.css' type='text/css' rel='stylesheet' /><link href='https://d132x6oi8ychic.cloudfront.net/higherlogic/microsite/generatecss/2b495af7-ef43-40d3-8f8d-d42fc2073d1a/939633a7-7477-45a6-b147-239f9fccc7b2/638678046276600000/34' type='text/css' rel='stylesheet' /><link type='text/css' rel='stylesheet' href='https://cdn.jsdelivr.net/npm/instantsearch.css@8.0.0/themes/satellite-min.css' /><link type='text/css' rel='stylesheet' href='https://maxcdn.bootstrapcdn.com/font-awesome/4.5.0/css/font-awesome.min.css' /><link type='text/css' rel='stylesheet' href='https://fonts.googleapis.com/css?family=Dosis:500,700' /><link type='text/css' rel='stylesheet' href='https://fonts.googleapis.com/css?family=Open+Sans:400,700' /><link type='text/css' rel='stylesheet' href='https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick.css' /><link type='text/css' rel='stylesheet' href='https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick-theme.css' /><link type='text/css' rel='stylesheet' href='https://use.typekit.net/cqp4ikw.css' /><link type='text/css' rel='stylesheet' href='https://use.typekit.net/zyl7cfs.css' /><link rel="stylesheet" type="text/css" href="https://d2x5ku95bkycr3.cloudfront.net/App_Themes/Common/PhoneLogo.css" /><script type='text/javascript' src='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/JavaScript/promise-fetch-polyfill.js'></script><script type='text/javascript' src='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/JavaScript/systemjs/3.1.6/system.min.js'></script><script type='systemjs-importmap' src='/HigherLogic/JavaScript/importmapping-cdn.json?638679636564874973'></script><script type='text/javascript' src='https://d3gliviwslgzfo.cloudfront.net/WebRoot/stable/Bundles/hlq-2024-05-08.js'></script><script src='https://d3gliviwslgzfo.cloudfront.net/WebRoot/stable/Bundles/hlqmigrate-2024-05-08.js'></script><script type='text/javascript' src='https://d3gliviwslgzfo.cloudfront.net/WebRoot/stable/Bundles/hlqui-2024-05-08.js'></script><script src='https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/bootstrap/3.4.1/js/bootstrap.min.js'></script><script type='text/javascript'>var higherlogic_crestApi_origin = 'https://api.connectedcommunity.org'</script><script type='text/javascript' src='/HigherLogic/CORS/easyXDM/easyXDM.Min.js'></script><script src="https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/prism.min.js" integrity="sha512-axJX7DJduStuBB8ePC8ryGzacZPr3rdLaIDZitiEgWWk2gsXxEFlm4UW0iNzj2h3wp5mOylgHAzBzM4nRSvTZA==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/plugins/autoloader/prism-autoloader.min.js" integrity="sha512-xCfKr8zIONbip3Q1XG/u5x40hoJ0/DtP1bxyMEi0GWzUFoUffE+Dfw1Br8j55RRt9qG7bGKsh+4tSb1CvFHPSA==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><script type='text/javascript' src='https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/Bundles/Desktop_bundle.min.a15963cc8802bf5ef87ffb22f53b2f3528e2cc6f.hash.js'></script><script type='text/javascript' src='https://cdnjs.cloudflare.com/ajax/libs/html2pdf.js/0.9.2/html2pdf.bundle.min.js'></script><script type='text/javascript' src='https://cdn.jsdelivr.net/npm/instantsearch.js@4.56.11/dist/instantsearch.production.min.js'></script><script type='text/javascript' src='https://cdn.jsdelivr.net/npm/algoliasearch@4.20.0/dist/algoliasearch-lite.umd.js'></script><script type='text/javascript' src='https://use.typekit.net/fho7nrh.js'></script><script type='text/javascript' src='https://use.fortawesome.com/7f3536d6.js'></script><script type='text/javascript' src='https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick.min.js'></script><script type='text/javascript' src='https://cdnjs.cloudflare.com/ajax/libs/jspdf/1.3.2/jspdf.debug.js'></script><script type='text/javascript' src='https://unpkg.com/jspdf-autotable'></script><script type='text/javascript' src='https://use.fortawesome.com/39cff8dc.js'></script><meta property="og:title" content="SITC Immunotherapy Surrogate Endpoints Initiative"><script>window.CDN_PATH = 'https://d3uf7shreuzboy.cloudfront.net'</script><script>var filestackUrl = 'https://static.filestackapi.com/filestack-js/3.28.0/filestack.min.js'; var filestackUrlIE11 = 'https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/JavaScript/filestack.ie11.min.js';</script><script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-M6VQVS2');</script><style type="text/css"> /* <![CDATA[ */ #AuxMenu img.icon { border-style:none;vertical-align:middle; } #AuxMenu img.separator { border-style:none;display:block; } #AuxMenu img.horizontal-separator { border-style:none;vertical-align:middle; } #AuxMenu ul { list-style:none;margin:0;padding:0;width:auto; } #AuxMenu ul.dynamic { z-index:1; } #AuxMenu a { text-decoration:none;white-space:nowrap;display:block; } #AuxMenu a.static { text-decoration:none;border-style:none;padding-left:0.15em;padding-right:0.15em; } #AuxMenu a.popout { background-image:url("/WebResource.axd?d=YAYach_zykzn7tRotFpEUgPcmfxMEirJJbHjv1eyOjNdBPK5HoEdAnfGFukc58K67jLPVTWTpJyknpgk4latoCQA26v04M1A0QgNeBGS6E41&t=638610727965203766");background-repeat:no-repeat;background-position:right center;padding-right:14px; } /* ]]> */ </style></head> <body class="bodyBackground resistance interior "> <noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-M6VQVS2" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div id="MPOuterMost" class="container full"> <form method="post" action="./resistance" onsubmit="javascript:return WebForm_OnSubmit();" id="MasterPageForm" class="form"> <div class="aspNetHidden"> <input type="hidden" name="ScriptManager1_TSM" id="ScriptManager1_TSM" value="" /> <input type="hidden" name="StyleSheetManager1_TSSM" id="StyleSheetManager1_TSSM" value="" /> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['MasterPageForm']; if (!theForm) { theForm = document.MasterPageForm; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/WebForms.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ window.WebForm_PostBackOptions||document.write('<script type="text/javascript" src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZCysh0Rza-opNMWyg1agS699-uaqgDeXVYaC9p3B4flwmG6Z-pseOBX2yAM0242ZJQ2&t=638610727965203766"><\/script>');//]]> </script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/MenuStandards.js" type="text/javascript"></script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/MicrosoftAjax.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ (window.Sys && Sys._Application && Sys.Observer)||document.write('<script type="text/javascript" src="/ScriptResource.axd?d=uHIkleVeDJf4xS50Krz-yGmM3FUUKgMXBnGB-y9PUoA6c6OLLq72GccOY_bbebC2oGQXIBEGAdoh7nVSCNYbHTX96ldDalK0OGdVPOAe9hZ7yy0UrRh4Knj32rnoIBHx3FGol7tSrRs7SO50v-ULhrATUZBm94PyJFxix57QnrA1&t=ffffffffb201fd3f"><\/script>');//]]> </script> <script src="https://ajax.aspnetcdn.com/ajax/4.6/1/MicrosoftAjaxWebForms.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ (window.Sys && Sys.WebForms)||document.write('<script type="text/javascript" src="/ScriptResource.axd?d=Jw6tUGWnA15YEa3ai3FadM5BHXKhtzCx84axnaRtN23djx2FZN_1ntEpDs_VH-_G7aVzawMgauQYbafMK6kk1JDxsFhgH4if5y1IWglVXj1IAvGMpPgH6s5Mk-E6DKqQQhJDQjAOoyO9IGeTtDzWPsjMvy9g1yXi8tyXU85S7vE1&t=ffffffffb201fd3f"><\/script>');function WebForm_OnSubmit() { null; return true; } //]]> </script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="738F2F5A" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="CfDJ8GYwqx9YzLZGmPQ2hZZF70JShi8c3vZ5c1/7+YRYrQgWfWBmBjopPsrwSYHu/kio8JEdV11pudiLyQbeHElLTerGtQtKuQvFIR5gnorsOFcWOi6ARTxRAlwU0L6IyckBqaQRrbx270IC5cWjt64nPb5xI3tIXi5z7otQ9SSu3zc5XSaqdwab1vKCb8mn+l8o4TSTgthXYO0iUBRQJyECIjg=" /> </div> <input name="__HL-RequestVerificationToken" type="hidden" value="CfDJ8GYwqx9YzLZGmPQ2hZZF70I_PkJGRDkm31hBdo-FjIRQ96MpLd2NZogCj_5kcxpBM1MiEGcl9htgC8osPfXTjTsFozBgkSIHD2ElK0xr3briFx_vFg40ljhsYr7tziOR0DUio9gmsoG-1XVuYymdq0A1" /> <div id="pnlCookieNotification" class="row cookie-notification-bar banner-bottom"> <div class="col-md-10 message-container"> <span id="lblCnMessage">This website uses cookies to deliver to you the best experience possible on SITC CONNECT. By continuing to use this site, you are providing to us your consent to ensure you receive such an experience.</span>  <a id="hypCnLearnMore" href="http://www.sitcancer.org/aboutsitc/privacy-policy" target="CookieNotification">View our privacy policy to learn more.</a> </div> <div class="col-md-2"> <div class="pull-right"> <button type="button" class="btn btn-success" data-microsite-key="2c19e5a6-3adb-4d01-b46c-c01e11745b3a" onclick="HigherLogic.Microsites.Ui.dropCookieNotification(this);"> <span class="glyphicon glyphicon-ok"></span> OK </button> </div> </div> </div> <div id="GlobalMain"> <script type="text/javascript"> //<![CDATA[ Sys.WebForms.PageRequestManager._initialize('ctl00$ScriptManager1', 'MasterPageForm', [], [], [], 90, 'ctl00'); //]]> </script> </div> <div id="GlobalMessageContainer"> <div id="GlobalMessageContent" > <img ID="GlobalMsg_Img" alt="Message Image" src=""/>   <span id="GlobalMsg_Text"></span><br /><br /> </div> </div> <div id="react-setup" style="height:0"> <script> var formTokenElement = document.getElementsByName('__HL-RequestVerificationToken')[0]; var formToken = formTokenElement? formTokenElement.value : ''; window.fetchOCApi = function(url, params) { return fetch(url, { method: 'POST', body: JSON.stringify(params), headers: { RequestVerificationFormToken: formToken, 'Content-Type': 'application/json' } }).then(function(response) { return response.json(); }).then(function(body) { return body.data }); } </script> <div id="__hl-activity-trace" traceId="b041a0dc7014d47d5b55d84080b60710" spanId="c85529b187896c0e" tenantCode="SITCANCER" micrositeKey="2c19e5a6-3adb-4d01-b46c-c01e11745b3a" navigationKey="69ddd760-2c67-4721-8fff-94df2f9351af" navigationName="resistance" viewedByContactKey="00000000-0000-0000-0000-000000000000" pageOrigin="http://www.sitcancer.org" pagePath="/advocacy/access-advocacy-summits-initiatives/resistance" referrerUrl="" userHostAddress="8.222.208.146 " userAgent="Mozilla/4.0 (compatible; MSIE 7.0; Windows NT 6.0; SLCC1; .NET CLR 2.0.50727; .NET CLR 3.0.04506; .NET CLR 3.5.21022; .NET CLR 1.0.3705; .NET CLR 1.1.4322)" ></div> <div id="page-react-root"></div> <script id="hlReactRootLegacyRemote" defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRootLegacy/ReactRootLegacy~hlReactRootLegacyRemote.bundle.9f40fbf62dca9a1c1650.hash.js"></script> <script>window.reactroot_webpackPublicPath = 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/'</script> <script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~runtime~main.bundle.68f058f1ada4ceae59dd.hash.js"></script> <script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~react-_yarn_cache_react-npm-18_2_0-1eae08fee2-b9214a9bd7_zip_node_modules_react_index_js.bundle.012593f3ef708f027ac2.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~vendor-_yarn___virtual___react-dom-virtual-05f150c4a1_0_cache_react-dom-npm-18_2_0-dd675bca1c-65c11b.bundle.8b02460446e4027ef67f.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~vendor-_yarn___virtual___react-dom-virtual-05f150c4a1_0_cache_react-dom-npm-18_2_0-dd675bca1c-17e4a5.bundle.1dbb26f4013744b692d1.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~vendor-_yarn_cache_lodash-npm-4_17_21-6382451519-c08619c038_zip_node_modules_lodash_lodash_js.bundle.8d689d0e26f432a3f17d.hash.js"></script><script defer src="https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/ReactRoot/ReactRoot~main.bundle.d9c6907ad1d4db1ca2e8.hash.js"></script> <script> window.hl_tinyMceIncludePaths = { cssIncludes: 'https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/Font-Awesome/6.4.2-pro/css/all.min.css|https://cdnjs.cloudflare.com/ajax/libs/prism/1.24.1/themes/prism.min.css|https://d2x5ku95bkycr3.cloudfront.net/HigherLogic/bootstrap/3.4.1/css/bootstrap.min.css|https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/Bundles/Desktop_bundle.min.d7804150d2a3d23b0f7bd53234959d21d94a14f1.hash.css|https://ajax.googleapis.com/ajax/libs/jqueryui/1.10.1/themes/base/jquery-ui.css|https://d132x6oi8ychic.cloudfront.net/higherlogic/microsite/generatecss/2b495af7-ef43-40d3-8f8d-d42fc2073d1a/939633a7-7477-45a6-b147-239f9fccc7b2/638678046276600000/34|https://cdn.jsdelivr.net/npm/instantsearch.css@8.0.0/themes/satellite-min.css|https://maxcdn.bootstrapcdn.com/font-awesome/4.5.0/css/font-awesome.min.css|https://fonts.googleapis.com/css?family=Dosis:500,700|https://fonts.googleapis.com/css?family=Open+Sans:400,700|https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick.css|https://cdn.jsdelivr.net/jquery.slick/1.6.0/slick-theme.css|https://use.typekit.net/cqp4ikw.css|https://use.typekit.net/zyl7cfs.css', tinymcejs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce.bc594acd1c86ca782a5f0446e0276d20202ffaf9.hash.js', hashmentionjs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce_hashmention.94b265db0d98038d20e17308f50c5d23682bf370.hash.js', mentionjs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce_mention.a35f893e40ce48b298979135724cd9e6ad18dde1.hash.js', hashtagjs: 'https://d3uf7shreuzboy.cloudfront.net/WebRoot/stable/Desktop/JS/Common/hl_common_ui_tinymce_hashtag.5579d26160cf6c00ace1fde0afcb2aacaf5baceb.hash.js' }; </script> <script> window.addEventListener('DOMContentLoaded', function (){ window.renderReactRoot( [], 'page-react-root', {"tenant":{"name":"Society for Immunotherapy of Cancer","logoPath":"https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC-pms-horz_430px.png","contactSummary":"<address> 555 East Wells Street, Suite 1100<br />Milwaukee WI 53202-3823<br />United States<br />Phone: +1 414-271-2456<br /></address>"},"communityKey":"00000000-0000-0000-0000-000000000000","micrositeKey":"2c19e5a6-3adb-4d01-b46c-c01e11745b3a","canUserEditPage":false,"isUserAuthenticated":false,"isUserSuperAdmin":false,"isUserCommunityAdmin":false,"isUserSiteAdmin":false,"isUserCommunityModerator":false,"currentUserContactKey":"00000000-0000-0000-0000-000000000000","isTopicCommunity":false,"isSelfModerationCommunity":false,"loginUrl":"https://sitc.execinc.com/HigherLogic/HLLoginRedirect.aspx?Redirect=","colorPickerDefaults":{"primaryColor":null,"textOnPrimary":null,"secondaryColor":null,"textOnSecondary":null,"linkColor":null,"linkHoverColor":null,"footerBackgroundColor":null,"footerTextColor":null}} ) }); </script> <svg aria-hidden="true" style="height: 0px;"> <defs> <linearGradient id="skeleton-svg-gradient" x1="0" x2="1" y1="0" y2="1"> <stop offset="0%" stop-color="rgba(239, 239, 239, 0.25)"> <animate attributeName="stop-color" values="rgba(239, 239, 239, 0.25); rgba(68, 72, 85, 0.2); rgba(239, 239, 239, 0.25);" dur="3s" repeatCount="indefinite"></animate> </stop> <stop offset="100%" stop-color="rgba(68, 72, 85, 0.2)"> <animate attributeName="stop-color" values="rgba(68, 72, 85, 0.2); rgba(239, 239, 239, 0.25); rgba(68, 72, 85, 0.2);" dur="3s" repeatCount="indefinite"></animate> </stop> </linearGradient> </defs> </svg> </div> <div id="MPOuterHeader" class="row siteFrame"> <div class="col-md-12"> <div id="HEADER" class="row"> <div class="col-md-12"> <div class="ContentUserControl search-field-wrapper"> <script type="text/javascript"> System.import('Common/SearchBox.js').then(function () { $('#AddlContentHeaderTop_ctl01_SearchButton').click(function () { $('#AddlContentHeaderTop_ctl01_hiddenSearchButton').click(); }); $('#AddlContentHeaderTop_ctl01_SearchOptions').click(function (e) { e.stopPropagation(); }); if ('False' == 'True') { $('#AddlContentHeaderTop_ctl01_SearchTerm').click(function (e) { $('#AddlContentHeaderTop_ctl01_SearchBoxToggle').addClass('open'); e.stopPropagation(); }); $('#AddlContentHeaderTop_ctl01_SearchTerm').focus(function (e) { $('#AddlContentHeaderTop_ctl01_SearchBoxToggle').addClass('open'); e.stopPropagation(); }); $('#AddlContentHeaderTop_ctl01_EndDate').hide(); $('#AddlContentHeaderTop_ctl01_StartDate').hide(); $('#AddlContentHeaderTop_ctl01_SearchTerm').focus(function () { $('#AddlContentHeaderTop_ctl01_SearchOptions').show(); }); $('#AddlContentHeaderTop_ctl01_DateRangeDDL').change(function () { if ($('#AddlContentHeaderTop_ctl01_DateRangeDDL').find(":selected").text() == 'on this day') { $('#AddlContentHeaderTop_ctl01_StartDate').show(); $('#AddlContentHeaderTop_ctl01_EndDate').hide(); $('#AddlContentHeaderTop_ctl01_EndDate').val(""); } else if ($('#AddlContentHeaderTop_ctl01_DateRangeDDL').find(":selected").text() == 'All') { $('#AddlContentHeaderTop_ctl01_EndDate').hide(); $('#AddlContentHeaderTop_ctl01_StartDate').hide(); } else { $('#AddlContentHeaderTop_ctl01_StartDate').show(); $('#AddlContentHeaderTop_ctl01_EndDate').show(); } }); } $('#AddlContentHeaderTop_ctl01_SearchInputs') .hl_ui_common_searchBox({ controlId: 'AddlContentHeaderTop_ctl01_SearchInputs', inputId: 'AddlContentHeaderTop_ctl01_SearchTerm', buttonId: 'AddlContentHeaderTop_ctl01_hiddenSearchButton' }); }); </script> <button id="SearchToggleIcon" type="button" class="btn btn-default" style="display: none;" role="button" aria-label="searchToggle"> <span class="glyphicon glyphicon-search" style="vertical-align: middle"></span> </button> <div id="AddlContentHeaderTop_ctl01_newSearchBox"> <div id="AddlContentHeaderTop_ctl01_SearchInputs" class="SearchInputs"> <div id="AddlContentHeaderTop_ctl01_WholeSearch" onkeypress="javascript:return WebForm_FireDefaultButton(event, 'AddlContentHeaderTop_ctl01_hiddenSearchButton')"> <div class="input-group" style="vertical-align: middle"> <input name="ctl00$AddlContentHeaderTop$ctl01$SearchTerm" type="text" id="AddlContentHeaderTop_ctl01_SearchTerm" class="form-control" autocomplete="off" qa-id="search-term" aria-label="search box" placeholder="search" Title="search" style="font-weight: normal;" /> <div id="AddlContentHeaderTop_ctl01_SearchBoxToggle" class="input-group-btn search-box-toggle"> <button id="AddlContentHeaderTop_ctl01_OptionsButton" type="button" style="display: none;" class="btn btn-default dropdown-toggle" data-toggle="dropdown" aria-label="search options"> <span class="caret"></span> <span class="sr-only">Search Options</span> </button> <button id="AddlContentHeaderTop_ctl01_SearchButton" type="button" class="btn btn-default " role="button" aria-label="search"> <span class="glyphicon glyphicon-search" style="vertical-align: middle"></span> </button> <ul class="dropdown-menu pull-right" role="menu"> <li> </li> </ul> </div> <input type="submit" name="ctl00$AddlContentHeaderTop$ctl01$hiddenSearchButton" value="" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions("ctl00$AddlContentHeaderTop$ctl01$hiddenSearchButton", "", true, "", "", false, false))" id="AddlContentHeaderTop_ctl01_hiddenSearchButton" style="display: none;" /> </div> </div> </div> </div> </div><div class="ContentItemHtml join-renew"> <div class="HtmlContent"><ul> <li><a href="https://sitc.execinc.com/edibo/Signup?_ga=2.186844974.764178562.1672778726-1617584964.1657890282" target="_blank" rel="noopener">Join SITC</a></li> <li><a href="https://www.sitcancer.org/membership/renew" target="_blank" rel="noopener">Renew</a></li> </ul></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml make-a-gift"> <div class="HtmlContent"><a href="https://sitc.sitcancer.org/donate/?_ga=2.4473523.1866415943.1648138048-1544668743.1643294471">Make a Gift</a></div><div class="HtmlFooter"></div></div><div class="ContentUserControl"> <script charset="utf-8">function handleStickyHeader() { var headerHeight = $('#MPOuterHeader').outerHeight(); // handle mobile navigation being present if ($(window).width() > 767) { $("#MPContentArea").css('padding-top', headerHeight + 'px'); } else { $("#MPContentArea").css('padding-top', '0'); } } $(function () { handleStickyHeader(); $(window).resize(function () { handleStickyHeader(); }); setTimeout(function () { handleStickyHeader(); }, 250); var headerHeight = $(MPOuterHeader).height(); $('a').on('click', function (event) { if ($(this).is('a[href^="#"]')) { event.preventDefault(); var hash = this.hash; $('html, body').animate({ scrollTop: $(hash).offset().top - 0 }, 500, function () { window.location.hash = headerHeight; } ); } }); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$('body').css('visibility', 'hidden'); $(document).ready(function() { $('body').css('visibility', 'visible').hide().fadeIn('slow'); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(function() { $(".accordion-heading").each(function() { $(this).next(".accordion-text").andSelf().wrapAll("<div class='accordion-wrap' />"); }); $('.accordion-heading').on('click', function() { var items = []; $('.accordion-wrap').each(function (i, item) { items.push(item); }); $parent_box = $(this).closest('.accordion-wrap'); $parent_box.find('.accordion-text').slideToggle(600, 'swing'); $parent_box.toggleClass('open'); }); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(function() { if (window.location.href.indexOf('#tab') > -1) { var url = window.location.href; str = url.split('#').pop(); // console.log(str[str.length - 1]); tabNum = '.tab-content.page-' + str[str.length - 1]; console.log(tabNum); $('.tab-content').hide(); $(tabNum).show(); } else { $('.tab-content').hide(); $('.tab-content.page-1').show(); } $('.tab-content').wrapAll('<div class="tab-content-wrap"></div>'); $('.tab-links li').click(function() { var elem = $(this).context, link = $(elem).find('a'), elementId = link.attr('id'); $('.tab-links li').removeClass('active'); $(this).addClass('active'); showTabContent(elementId); }); $('.tab-links ul li:first-child').addClass('active') }); function showTabContent(tabClass) { $('.tab-content').each(function() { var self = $(this), classes = self.attr('class'); if (classes.indexOf(tabClass) >= 0 || tabClass === 'all') { self.show(); } else { self.hide(); } }); }</script> </div><div class="ContentUserControl"> <script charset="utf-8">var popupCookies = [], link, href, target; $(function () { popup = $(".popup"); if (popup.length > 0) { handlePopup(); } }); function getCookies(cname) { popupCookies = []; var name = cname; var decodedCookie = decodeURIComponent(document.cookie); var ca = decodedCookie.split(";"); for (var i = 0; i < ca.length; i++) { var c = ca[i]; while (c.charAt(0) == " ") { c = c.substring(1); } if (c.indexOf(name) == 0) { popupCookies.push(c); } } // return ""; } function handlePopup() { getCookies("popup"); var popups = $("#HEADER .popup").toArray(); for (var i = 0; i < popupCookies.length; i++) { var text = popupCookies[i].substring(popupCookies[i].indexOf("=") + 2, 50); for (var j = 0; j < popups.length; j++) { if ($(popups[j]).text().indexOf(text) >= 0) { $(popups[j]).hide(); } else { $(popups[j]).append( '<button type="button" onclick="closePopup(this);"><i class="fal fa-times"></i></button>' ); } } } if (!popupCookies.length) { $("#HEADER .popup .HtmlContent").append( // '<button type="button" onclick="closePopup(this);"><i class="fal fa-times"></i></button>' '<button type="button" onclick="closePopup(this);" class="close-popup">Close</button>' ); } link = $('.popup em a'); href = $(link).attr('href'); target = $(link).attr('target'); $(link).closest('em').hide(); } function handleClick() { closePopup(link); if (target == '_blank') { window.open(href); } else { window.location.href = href; } } function closePopup(elem) { $(elem).closest(".popup").addClass('slide-out'); getCookies("popup"); var text = $(elem).closest(".popup").text(), num = popupCookies.length + 1; var date = new Date(), expires = "expires="; date.setDate(date.getDate() + 1); expires += date.toGMTString(); document.cookie = "popup" + num + "='" + text + "; " + expires + "; path=/"; console.log(document.cookie); }</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(function () { $('#NAV .navbar-default ul.nav>li').each(function () { navAnchor = $(this).find('>a'); navText = $(navAnchor).text(); megaMenu = $(this).find('>ul.megamenu>li:first-of-type'); menuTitle = '<h6>' + navText + ' </h6>'; $(menuTitle).prependTo(megaMenu); }); $('#NAV #MPButtonBar ul.nav .megamenu').each(function () { firstChildLi = $(this).find('>li:first-child'); notFirstChildUl = $(this).find('>li:not(:first-child) ul'); $(firstChildLi).append(notFirstChildUl); }); $('.dropdown-header + .child').wrap('<ul class="children" />'); $('.children').each(function () { var self = $(this); while ($(self).find('+ *').hasClass('child')) { $(self).append($(self).find('+ .child')); } $(self).appendTo($(self).prev()); }); // var dropdownNav = document.querySelectoAll('.megamenu .dropdown-header'); // $(dropdownNav).hover(function () { // var self = $(this); // $(self).toggleClass('open'); // }); $('.megamenu .dropdown-header').hover(function () { $(this).toggleClass('open'); }); // $('.megamenu .dropdown-header').mouseover(function () { // $(this).addClass('open'); // }); // $('.megamenu .dropdown-header').mouseout(function (){ // $(this).removeClass('open'); // }); while ($('#NAV #MPButtonBar ul.nav .megamenu>li:first-child>ul').is(':parent')) { $('#NAV #MPButtonBar ul.nav .megamenu>li:first-child>ul').each(function () { firstChild = $(this).find('>li:first-child'); $(firstChild).appendTo($(this).parent()); }); } $('#NAV #MPButtonBar ul.nav .megamenu>li:first-child').each(function () { li = $(this).find('>li'); $(li).wrapAll('<ul />'); }); // $('.megamenu .dropdown-header').click(function () { // toggleOpen(); // $(this).parent().parent().parent().addClass('open'); // }); $('#NAV #MPButtonBar ul.nav .megamenu>li:first-child>ul:empty').remove(); $('#NAV #MPButtonBar ul.nav .megamenu>li:empty').remove(); var navHeight = $('#NAV').height(); $('#MPOuter').css('padding-top', parseInt(navHeight) - 105); });</script> </div><div class="ContentUserControl"> <script charset="utf-8">$(document).ready(function () { // page content $('.user-groups').wrapAll('<div class="container" />'); $('.horizontal ul li').addClass('col-md-4'); $('.section6').parent('.row').addClass('connect-bg'); $('.connect-bg').wrapInner('<div class="container" />'); $('.audience .section16').addClass('bg-blue').wrapInner('<div class="container" />'); $('.interior #PageTitleH1').prependTo('.banner-page .section1'); if ($('#MainCopy_ContentWrapper').hasClass('banner-page')) { $('body').addClass('banner-page'); } // header $('.search-field-wrapper, .join-renew, .make-a-gift ').wrapAll('<div class="row row-wide clearfix header-content " />'); $('.header-content').insertBefore('.HLWelcome.HLWelcomeHeader'); $('.search-field-wrapper, .join-renew, .make-a-gift').wrapAll('<div class="col-md-12 " />'); $('#MPAuxNav ul.level1 li a[href*="subscribe-btn"]').appendTo('.header-content .col-md-12'); $('.header-content').prepend('<button type="button" class="nav-toggle" onclick="toggleMenu();" aria-label="close menu"><i class="far fa-bars"></i></button>'); $('.profile-link-btn a').addClass('btn btn-sm inline alert-warning').appendTo('#ProfileContainer .welcome-links'); }); function toggleMenu() { if ($('.header-content').hasClass('open')) { closeMenu(); } else { openMenu(); } } function closeMenu() { $('.header-content').removeClass('open'); } function openMenu() { $('.header-content').addClass('open'); }</script> </div><div class="ContentItemHtml"><div class="HtmlContent"><p> <script data-cfasync="false">(function(w,i,s,e){window[w]=window[w]||function(){(window[w].q=window[w].q||[]).push(arguments)};window[w].l=Date.now();s=document.createElement('script');e=document.getElementsByTagName('script')[0];s.defer=1;s.src=i;e.parentNode.insertBefore(s, e)})('wisepops', 'https://wisepops.net/loader.js?v=3&h=aPXRcreuQM');</script> </p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"> <p> <script type="text/javascript"> !function(e,t,n,s,u,a){e.twq||(s=e.twq=function(){s.exe?s.exe.apply(s,arguments):s.queue.push(arguments); },s.version='1.1',s.queue=[],u=t.createElement(n),u.async=!0,u.src='https://static.ads-twitter.com/uwt.js', a=t.getElementsByTagName(n)[0],a.parentNode.insertBefore(u,a))}(window,document,'script'); twq('config','o4hgv');</script> </p> </div><div class="HtmlFooter"></div></div> <div id="MPimage" class="MPimage"> <div id="mainskiplinkholder" class="skiplinkholder"><a id="skiplink" href="#MPContentArea">Skip to main content (Press Enter).</a></div> <div id="MPheader" class="MPheader"> <div class="row"> <div class="col-md-12"> <div class="pull-right"> <div class="inline"> <div class='HLWelcome HLWelcomeHeader'> <script type="text/javascript"> $(document).ready(function () { $('.Picture_Profile').tipTip({ delay: 200 }); }); function toggleHelp() { if ($("ul#CompleteBarHelpContainer").is(":visible")) { $("ul#CompleteBarHelpContainer").hide(); } else { $("ul#CompleteBarHelpContainer").show(); } } // Added as onClick for logoutLink on back end if opted in // On logout, removes the CREST API cookie that was added on login, whose value is a token used to authenticate to the API function removeApiToken(tenantKey, token) { hl_webapi_remove_cookie(tenantKey, token, tenantKey, "HLApiPassThrough"); window.location = ""; return false; } $(document).on('click', "span.CompleteBarClose", function (e) { e.stopPropagation(); toggleHelp(); $(".btn-group").find('button#BtnShowProfile').dropdown('toggle'); }); </script> <div class="EndDiv"> </div> <div id="Welcome_NotLoggedIn" class="Login"> <a id="Welcome_LoginLink" class="btn btn-primary" qa-id="login-link" href="https://sitc.execinc.com/HigherLogic/HLLoginRedirect.aspx?Redirect=https%3a%2f%2fwww.sitcancer.org%2fadvocacy%2faccess-advocacy-summits-initiatives%2fresistance">Sign in</a> </div> </div> </div> </div> <div class="pull-right"> <div id="auxskiplinkholder" class="skiplinkholder"> <a id="auxskiplink" href="#Logo">Skip auxiliary navigation (Press Enter).</a> </div> <div id="MPAuxNav" class="inline vertical-align-middle"> <div CssSelectorClass="MPAuxNav" id="AuxMenu"> <ul class="level1"> <li><a class="level1 MPAuxNav" href="/subscribe-btn">Subscribe</a></li> </ul> </div> </div> </div> </div> </div> <div id="Logo" class="row" role="banner"> <div class="col-md-12"> <div id="DesktopLogoDiv" class="LogoImg inline"> <a href='https://www.sitcancer.org/home' style=''> <img src='https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC-pms-horz_430px.png' alt="Society for Immunotherapy of Cancer (SITC) logo. This will take you to the homepage" /></a> </div> <div id="PhoneLogoDiv" class="LogoImg inline"> <a href='' style=''> <img src='//higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/sitc_log_color_250px.png' alt="Society for Immunotherapy of Cancer (SITC) logo. This will take you to the homepage" /></a> </div> <div id="SloganText" class="SloganText inline"></div> </div> </div> </div> </div> <div style="clear: both"></div> <div class="ContentItemHtml"> <div class="HtmlContent"><script type="text/javascript" src="https://sitc.sitcancer.org/_include/js/util.js?v=2"></script></div><div class="HtmlFooter"></div></div> </div> </div> <div id="NAV" class="row traditional-nav"> <div class="col-md-12"> <div id="navskiplinkholder" class="skiplinkholder"><a id="navskiplink" href="#MPContentArea">Skip main navigation (Press Enter).</a></div> <div id="MPButtonBar"> <nav class="navbar navbar-default"> <div class="navbar-header"> <button type="button" class="navbar-toggle" data-toggle="collapse" data-target=".navbar-ex1-collapse, .icon-bar-start"> <span class="sr-only">Toggle navigation</span> <span class="icon-bar-start"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> </div> <div class="collapse navbar-collapse navbar-ex1-collapse"> <div class="row"> <div class="col-md-12 "> <ul class="nav navbar-nav"> <li class="dropdown menu-large" ><a href="/education" id="megaanchor1" class="dropdown-toggle" data-toggle="dropdown">Educational & Scientific Programs <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu11" class="col-sm-4"><ul><li ><a href="/education/connect-ed" target="_blank">ConnectED</a></li><li ><a href="/education/winterschool-2025">Cancer Immunotherapy Winter School</a></li><li ><a href="/education/drug-development-summit">SITC Immuno-Oncology Drug Development Summit</a></li><li class="dropdown-header"><a href="/education/webinars-online">Webinars and Online Education</a></li><li class="child"><a href="/education/webinars-online/aci-webinars">Advances in Cancer Immunotherapy (ACI) Webinars</a></li><li class="child"><a href="/education/webinars-online/computational">AI in IO: SITC-NCI Computational IO Series</a></li><li class="child"><a href="/education/webinars-online/ibcg">Definitions, End Points, and Clinical Trial Designs for Bladder Cancer</a></li><li class="child"><a href="/education/webinars-online/expanding-access">Expanding Access to Cellular and Bispecific Therapies</a></li><li class="child"><a href="/education/webinars-online/glyco-immunology-webinar">2024 Glyco-Immunology Webinar Series</a></li><li class="child"><a href="/education/webinars-online/immune-exclusion-virtual-summit">Immune Exclusion Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/immunomodulation-vs">Immunomodulation of ADCs Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/immunoprevention">Immunoprevention Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/increasing-access-to-io-a-global-webinar-series">Increasing Access to IO: A Global Webinar Series</a></li><li class="child"><a href="/education/webinars-online/intralesional-vs">Intralesional Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/neuro-vs">Neuro Immuno-Oncology Virtual Summit</a></li><li class="child"><a href="/education/webinars-online/cpg-online-edu">SITC Clinical Practice Guidelines Online Education</a></li><li class="child"><a href="/education/webinars-online/cancer-io-deep-dive">Targets for Cancer IO: A Deep Dive Series</a></li><li ><a href="/education/cfp">Call for Proposals</a></li></ul></li><li id="megamenu12" class="col-sm-4"><ul><li class="dropdown-header"><a href="/education/annualmeeting">Annual Meeting & Pre-Conference Programs</a></li><li class="child"><a href="/education/annualmeeting/39th-annual-meeting" target="_blank">39th Annual Meeting & Pre-Conference Programs</a></li><li class="child"><a href="/education/annualmeeting/archive">Past and Future Annual Meetings & Pre-Conference Programs</a></li><li ><a href="/education/collaborative">Collaborative Education Programs</a></li><li ><a href="/education/patient-survivor-resources">Patient and Survivor Education and Resources</a></li><li class="dropdown-header"><a href="/education/workshops">Workshops</a></li><li class="child"><a href="/education/workshops/tme-workshop">Tumor Immune Microenvironment: A Holistic Approach</a></li><li class="child"><a href="/education/workshops/immune-targeting-workshop">Surfaceome Virtual Workshop</a></li><li class="child"><a href="/education/workshops/bispecificworkshop">Bispecific T cell Engagers Virtual Workshop</a></li><li class="child"><a href="/education/workshops/cytokines-workshop">Cytokines in Cancer Immunotherapy Virtual Workshop</a></li></ul></li><li id="megamenu13" class="col-sm-4"><ul><li ><a href="/education/aci">Advances in Cancer Immunotherapy</a></li><li ><a href="/education/sitc-biotech">SITC Biotech Initiative</a></li><li class="dropdown-header"><a href="/education/spring-scientific">Spring Scientific</a></li><li class="child"><a href="/education/spring-scientific/2025-spring-scientific">2025 Spring Scientific</a></li><li class="child"><a href="/education/spring-scientific/springscientificprograms">Past and Future Spring Scientific Programs</a></li><li ><a href="/education/events">Calendar of Events</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/professional-development" id="megaanchor2" class="dropdown-toggle" data-toggle="dropdown">Professional Development & Training <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu21" class="col-sm-6"><ul><li ><a href="/professional-development/certificate">Certificate in Cancer Immunotherapy</a></li><li ><a href="/professional-development/professional-interest-communities">Professional Interest Communities</a></li><li ><a href="/professional-development/fellowships">Fellowships</a></li><li class="dropdown-header"><a href="/professional-development/win2">Women in Cancer Immunotherapy Network (WIN)</a></li><li class="child"><a href="/professional-development/win2/win">Women in Cancer Immunotherapy Network 2024</a></li><li class="child"><a href="/professional-development/win2/win-community">Women in SITC Community</a></li><li ><a href="/professional-development/early-career-scientist">Early Career Scientist (ECS) Committee</a></li></ul></li><li id="megamenu22" class="col-sm-6"><ul><li class="dropdown-header"><a href="/professional-development/clinical-trials-training-resources">Clinical Trials Training and Resources</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/scion">SITC Clinical Immuno-Oncology Network (SCION) Workshop</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/mvp3">Maximizing the Value of Phase III Trials in Immuno-Oncology</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/ici-related-adverse-events-terminology-definitions">ICI-related Adverse Events Terminology Definitions</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/bladder-cancer-trial-design">Definitions, End Points, and Clinical Trial Designs for Bladder Cancer</a></li><li class="child"><a href="/professional-development/clinical-trials-training-resources/iict-paper">Intratumoral Immunotherapy Clinical Trial (IICT) Design</a></li><li ><a href="/professional-development/nci-immunotherapy-fellowship">NCI Immunotherapy Fellowship</a></li><li class="dropdown-header"><a href="/professional-development/sitc-sparkathon">SITC Sparkathon</a></li><li class="child"><a href="/professional-development/sitc-sparkathon/sparkathon-2025">Sparkathon 2025</a></li><li class="child"><a href="/professional-development/sitc-sparkathon/matching-donation-challenge">Support Sparkathon</a></li><li class="dropdown-header"><a href="/professional-development/other-resources">Other Resources</a></li><li class="child"><a href="/professional-development/other-resources/events2">Calendar of Events</a></li><li class="child"><a href="/professional-development/other-resources/path-sitc-leadership">Path to SITC Leadership</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/research" id="megaanchor3" class="dropdown-toggle" data-toggle="dropdown">Publications & Guidelines <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu31" class="col-sm-6"><ul><li class="dropdown-header"><a href="/research/jitc-2">Journal for ImmunoTherapy of Cancer</a></li><li class="child"><a href="/research/jitc-2/jitc">About JITC</a></li><li class="child"><a href="/research/jitc-2/become-a-reviewer">Become a Reviewer</a></li><li class="child"><a href="/research/jitc-2/for-authors2" target="_blank">For Authors</a></li><li class="child"><a href="/research/jitc-2/the-editors">From the Editors</a></li><li class="child"><a href="/research/jitc-2/jitc-collections-and-special-issues">JITC Collections and Special Issues</a></li><li class="dropdown-header"><a href="/research/sitc-immunotherapy-books">SITC Immunotherapy Books</a></li><li class="child"><a href="/research/sitc-immunotherapy-books/sitcs-guide-managing-immunotherapy-toxicity">SITC's Guide to Managing Immunotherapy Toxicity Textbook</a></li><li class="child"><a href="/research/sitc-immunotherapy-books/cancer-immunotherapy-principles-practice">Cancer Immunotherapy Principles and Practice Textbook, 2nd Ed.</a></li><li ><a href="/research/sitc-scientific-publications-news">SITC Scientific Publications News</a></li></ul></li><li id="megamenu32" class="col-sm-6"><ul><li class="dropdown-header"><a href="/research/cancer-immunotherapy-guidelines">SITC Clinical Practice Guidelines</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/cpg">Clinical Practice Guidelines</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/webinars">Clinical Practice Guidelines Online Education</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/cpg-app">Clinical Practice Guidelines Mobile App</a></li><li class="child"><a href="/research/cancer-immunotherapy-guidelines/cpg-news">SITC Cancer Immunotherapy Guideline News</a></li><li ><a href="/research/patient-resource-guides">Patient Resource Guides</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/advocacy" id="megaanchor4" class="dropdown-toggle" data-toggle="dropdown">Access & Advocacy <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu41" class="col-sm-6"><ul><li ><a href="/advocacy/new-page">SITC Immuno-oncology Drug Development Summit</a></li><li class="dropdown-header"><a href="/advocacy/access-advocacy-summits-initiatives">Summits and Initiatives</a></li><li class="child"><a href="/advocacy/access-advocacy-summits-initiatives/io-surrogate-endpoints">IO Surrogate Endpoints Initiative</a></li><li class="child"><a href="/advocacy/access-advocacy-summits-initiatives/resistance">IO Resistance Initiative</a></li><li class="child"><a href="/advocacy/access-advocacy-summits-initiatives/release-criteria">Release Criteria Initiative</a></li><li ><a href="/advocacy/global-access">Global Immunotherapy Access</a></li><li ><a href="/advocacy/expanding-access-to-cellular-and-bispecific-therapies">Expanding Access to Cellular and Bispecific Therapies</a></li></ul></li><li id="megamenu42" class="col-sm-6"><ul><li ><a href="/advocacy/policy">Policy</a></li><li ><a href="/advocacy/advocacy-news">Advocacy News</a></li><li ><a href="/advocacy/crisis-in-clinical-research">Crisis in Clinical Research</a></li><li ><a href="/advocacy/patient-survivor-resources">Patient & Survivor Education & Resources</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/membership" id="megaanchor5" class="dropdown-toggle" data-toggle="dropdown">Membership <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu51" class="col-sm-4"><ul><li ><a href="/membership/2024-sitc-election">2024 SITC Election</a></li><li ><a href="/membership/connect-a-colleague">Connect-a-Colleague</a></li><li class="dropdown-header"><a href="/membership/volunteer2">Volunteer</a></li><li class="child"><a href="/membership/volunteer2/volunteer">Volunteer with SITC</a></li></ul></li><li id="megamenu52" class="col-sm-4"><ul><li class="dropdown-header"><a href="/membership/academy-immuno-oncology">Academy of Immuno-Oncology</a></li><li class="child"><a href="/membership/academy-immuno-oncology/faio">About the Academy</a></li><li ><a href="/membership/corporate-membership">Corporate Membership</a></li></ul></li><li id="megamenu53" class="col-sm-4"><ul><li ><a href="/membership/details">Benefits, Categories & Application</a></li><li class="dropdown-header"><a href="/membership/members-only2">Members Only</a></li><li class="child"><a href="/membership/members-only2/member-directory">SITC Member Directory</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/funding" id="megaanchor6" class="dropdown-toggle" data-toggle="dropdown">Support SITC <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu61" class="col-sm-4"><ul><li class="dropdown-header"><a href="/funding/forward-fund">The Forward Fund</a></li><li class="child"><a href="/funding/forward-fund/moving-the-field-forward">Moving the Field Forward</a></li><li class="child"><a href="/funding/forward-fund/making-a-difference">Making a Difference</a></li><li class="dropdown-header"><a href="/funding/named-funds-and-awards2">Named Funds and Awards</a></li><li class="child"><a href="/funding/named-funds-and-awards2/young-investigator">Early Career Scientist Awards</a></li><li class="child"><a href="/funding/named-funds-and-awards2/smalley">Richard V. Smalley Memorial Award and Lectureship</a></li><li class="child"><a href="/funding/named-funds-and-awards2/rosenberg">Steven A. Rosenberg Scholars Award</a></li><li class="child"><a href="/funding/named-funds-and-awards2/weber">Dr. Weber Remembrance Fund</a></li><li class="child"><a href="/funding/named-funds-and-awards2/techawards">Technology Awards</a></li><li class="child"><a href="/funding/named-funds-and-awards2/mac-cheever">Martin "Mac" Cheever Travel Award Fund</a></li><li class="child"><a href="/funding/named-funds-and-awards2/sparkathon-accelerator">Sparkathon</a></li><li ><a href="/funding/the-checkpoints-band">The CheckPoints: SITC鈥檚 House Band</a></li></ul></li><li id="megamenu62" class="col-sm-4"><ul><li class="dropdown-header"><a href="/funding/ways-make-gift">Ways to Make a Gift</a></li><li class="child"><a href="/funding/ways-make-gift/donate-online">Donate</a></li><li class="child"><a href="/funding/ways-make-gift/new-page2">Stocks and Securities</a></li><li class="child"><a href="/funding/ways-make-gift/new-page3">Estate and Planned Gifts</a></li><li class="dropdown-header"><a href="/funding/corporate-giving">Corporate Support and Giving Opportunities</a></li><li class="child"><a href="/funding/corporate-giving/corporate-giving">Corporate Giving Opportunities</a></li><li class="child"><a href="/funding/corporate-giving/corporate-membership">Corporate Membership</a></li><li class="child"><a href="/funding/corporate-giving/educational-grants">Educational Grants</a></li><li class="child"><a href="/funding/corporate-giving/sponsorship">Sponsorship & Advertising</a></li><li ><a href="/funding/merchandise">SITC Merchandise</a></li></ul></li><li id="megamenu63" class="col-sm-4"><ul><li class="dropdown-header"><a href="/funding/honor-memorial">Honor and Memorial Gifts</a></li><li class="child"><a href="/funding/honor-memorial/in-honor">Make a Gift in Honor of a Loved One</a></li><li class="child"><a href="/funding/honor-memorial/in-memory">Make a Gift in Memory of a Loved One</a></li><li class="dropdown-header"><a href="/funding/donors-supporters">Our Donors and Supporters</a></li><li class="child"><a href="/funding/donors-supporters/2020-supporters813">2022 SITC Supporters</a></li><li class="child"><a href="/funding/donors-supporters/2021-forward-fund-donors"><em>Forward</em> Fund Donors</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/aboutsitc" id="megaanchor7" class="dropdown-toggle" data-toggle="dropdown">About SITC <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu71" class="col-sm-6"><ul><li ><a href="/aboutsitc/strategic-plan-2024-2026">Strategic Plan</a></li><li ><a href="/aboutsitc/awards">Awards and Recognition</a></li><li ><a href="/aboutsitc/career-connections">Career Connections</a></li><li class="dropdown-header"><a href="/aboutsitc/diversity-strategy">SITC鈥檚 DEI Strategy</a></li><li class="child"><a href="/aboutsitc/diversity-strategy/dei">Elevating a Rich Oncology Community: SITC鈥檚 DEI Strategic Plan</a></li><li class="child"><a href="/aboutsitc/diversity-strategy/virtual-roundtable">Virtual Roundtable on Diversity in Clinical Trial Enrollment</a></li><li ><a href="/aboutsitc/partnerships">Partnerships</a></li><li ><a href="/aboutsitc/contact-sitc">Contact SITC</a></li></ul></li><li id="megamenu72" class="col-sm-6"><ul><li ><a href="/aboutsitc/new-page">SITC Biotech Initiative</a></li><li ><a href="/aboutsitc/board">Board of Directors</a></li><li ><a href="/aboutsitc/get-involved">Committees, Task Forces and Professional Interest Communities</a></li><li ><a href="/aboutsitc/mission">Mission & Vision</a></li><li class="dropdown-header"><a href="/aboutsitc/media-room">Media Room</a></li><li class="child"><a href="/aboutsitc/media-room/sitc-press-releases">SITC Press Releases</a></li><li class="child"><a href="/aboutsitc/media-room/scientific-meeting-highlights">Scientific Meeting Highlights from SITC</a></li><li class="child"><a href="/aboutsitc/media-room/immunemonitor-archive">Immune Monitor Archive</a></li><li class="child"><a href="/aboutsitc/media-room/jitc-digest-archive">JITC Digest Archive</a></li><li class="child"><a href="/aboutsitc/media-room/cancer-immunotherapy-month">Cancer Immunotherapy Month</a></li><li ><a href="/aboutsitc/policies">SITC Policies</a></li></ul></li></li></ul><li class="dropdown menu-large" ><a href="/connect" id="megaanchor8" class="dropdown-toggle" data-toggle="dropdown">The Connect Community <b class="caret"></b></a><ul class="dropdown-menu megamenu row"><li id="megamenu81" class="col-sm-12"><ul><li ><a href="/connect/create-account">Create Account</a></li><li ><a href="/connect/my-profile">My Profile</a></li><li ><a href="/connect/my-communities">My Communities</a></li><li ><a href="/connect/mylibraries">My Libraries</a></li><li ><a href="/connect/thesentinel" target="_blank">The Sentinel - SITC Blog</a></li></ul></li></li></ul> </ul> </div> </div> </div> </nav> </div> <div class="MenuBarUnderline"> </div> </div> </div> </div> </div> <div id="MPOuter" class="row siteFrame "> <div id="ContentColumn" class="col-md-12">  <div id="BreadCrumb" class="BreadCrumb"> </div> <div id="MPContentArea" class="MPContentArea no-pageTitle-padding" role="main"> <h1 id="PageTitleH1" qa-attribute="PageTitleH1" style="display: none;" aria-hidden="true"> IO Resistance Initiative </h1> <input type="hidden" name="ctl00$DefaultMasterHdnCommunityKey" id="DefaultMasterHdnCommunityKey" value="00000000-0000-0000-0000-000000000000" /> <div id="FlashMessageContainer"> </div> <div id="MainCopy_ContentWrapper"> <div class="row row-full "><div class="col-md-12 section1"><div class="ContentItemHtml"> <div class="HtmlContent"><style> * { box-sizing: border-box; } .resistance-banner-bckgrnd { background: linear-gradient(to left, transparent, #1D4F91), url("https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Advocacy_and_Policy/Resistance_Web_Header.png"); background-size: cover; background-position: center; margin-left: -15px; margin-right: -15px; } .resistance-banner-container { display: flex; flex-direction: row; font-size: 14px; text-align: left; max-width: 1200px; justify-content: center; margin: auto; padding-top: 60px ; padding-bottom: 60px ; line-height: 1.8em; } .resistance-banner-logo { flex: 30%; margin: 5px; color: #ffffff; justify-content: center; align-items: center; } .resistance-banner-text { flex: 70%; margin: 5px; color: #ffffff; font-weight: 800; padding-left: 15px; } /* Style the resistance-navbar */ #resistance-navbar { background-color: #64A70B; margin-left: -15px; margin-right: -15px; display: flex; overflow: auto; white-space: nowrap; align-items: center; padding-left: 10px; justify-content: center; } /* resistance-navbar links */ #resistance-navbar a { display: flex; flex-direction: row; color: #f2f2f2; padding: 16px; text-decoration: none; font-weight: 700; text-transform: uppercase; font-size: 14px; } #resistance-navbar a:hover { color: #1D4F91; } .resistance-banner-button { border-radius: 30px; background-color: #64A70B; color: white; padding: 8px 20px; text-align: center; font-family: calibri, arial, sans-serif; text-decoration: none; font-weight: 900; letter-spacing: 1px; text-transform: uppercase; display: flex; font-size: 14px; margin: 2px 2px; transition-duration: 0.4s; cursor: pointer; float: left; transition: 0.3; } .resistance-banner-button:hover { color: white; background-color: #64A70B; opacity: 0.9; box-shadow: 0px 4px 14px rgb(0 0 0 / 7%); } /* Responsive layout - makes a one column-layout instead of two-column layout */ @media (max-width: 700px) { .resistance-banner-container { flex-direction: column; padding: 0px 15px; } #resistance-navbar { justify-content: space-between; } } </style> <div class="resistance-banner-bckgrnd"> <div class="resistance-banner-container"> <div class="resistance-banner-text"> <h1><strong><a id="dei-top"></a>IO <span>Resistance Initiative聽</span></strong></h1> <p><strong><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;">The Society for Immunotherapy of Cancer (SITC)</span></strong><span style="mso-bidi-font-family: Aptos; mso-bidi-theme-font: minor-latin;"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 12pt;">聽Immunotherapy Resistance Committee is convening stakeholders from across the field of immunotherapy to help develop unified definitions of immunotherapy resistance in order to support future drug development.</span></strong> <o:p></o:p></span></p> </div> <div class="resistance-banner-logo"></div> </div> </div> <div id="resistance-navbar"><br><br><a href="#overview">Overview</a><a href="#definitions">Definitions & Publications</a><a href="#committee">Committee</a></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section2"><div class="ContentItemHtml"> <div class="HtmlContent"><p><a id="overview"></a></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section3"><div class="ContentItemHtml"><div class="HtmlContent"><h2><strong>Overview</strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-6 section4"><div class="ContentItemHtml"> <div class="HtmlContent"><p class="MsoNormal"><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;">Since 2018, the SITC IO resistance initiative has been a multi-year endeavor that has included numerous efforts around defining resistance to immunotherapy across a multitude of settings and therapy combinations. With definitions anecdotally determined by leading experts in the field and published in the <em>Journal for ImmunoTherapy of Cancer (JITC)</em>, the SITC Immunotherapy Resistance Committee is looking to validate the definitions through real world evidence.聽</span><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;">Creating a pathway for validation of these definitions will allow for wider adoption and standardization across the field.</span></p> <p class="MsoNormal"><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;"></span><span style="color: rgb(255, 255, 255);">T</span></p></div><div class="HtmlFooter"></div></div></div><div class="col-md-6 section5"><div class="ContentItemHtml"><div class="HtmlContent"><p><a href="https://jitc.bmj.com/content/11/7/e007309?utm_source=society&utm_medium=referral&utm_campaign=usage&utm_content=americas-society&utm_term=sitc" target="_blank" rel="noopener"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Commentary_Cover_Cropped_2.png" class="img-responsive" alt="" data-mce-hlimagekey="d698f98d-c731-442d-8cda-0d326a3fd3f6" data-mce-hlselector="#TinyMceContent_7ba0ad41-30ac-96c9-1094-4eb14aa5f68c-tinyMceHtml" width="502" height="210" style="display: block; margin-left: auto; margin-right: auto;"></a></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section6"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"><a id="definitions"></a></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section7"><div class="ContentItemHtml"><div class="HtmlContent"><h2><strong><a id="crisis-organizers" target="_blank"></a>Definitions & Publications</strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section8"><div class="ContentItemHtml"><div class="HtmlContent"><p class="MsoNormal"><span style="font-size: 12pt; font-family: arial, helvetica, sans-serif;">The various efforts to determine IO resistance definitions have led to the creation of five manuscripts published in the <i>Journal for ImmunoTherapy of Cancer</i> (JITC) providing consensus definitions of resistance to single and combination immunotherapies to be used in clinical trial protocols.聽<o:p></o:p></span><o:p></o:p></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section9"><div class="ContentItemHtml accordion-heading container"><div class="HtmlContent"><h3>Monotherapy Resistance Definitions</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"><div class="HtmlContent"><p style="padding-left: 40px;"><span style="font-size: 12pt;">As the field of cancer immunotherapy continues to advance at a fast pace, treatment approaches and drug development are evolving rapidly to maximize patient benefit. New agents are commonly evaluated for activity in patients who had previously received a programmed death receptor 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitor as standard of care or in an investigational study. However, because of the kinetics and patterns of response to PD-1/PD-L1 blockade, and the lack of consistency in the clinical definitions of resistance to therapy, the design of clinical trials of new agents and interpretation of results remains an important challenge. To address this unmet need, the Society for Immunotherapy of Cancer convened a multistakeholder taskforce鈥攃onsisting of experts in cancer immunotherapy from academia, industry, and government鈥攖o generate consensus clinical definitions for resistance to PD-(L)1 inhibitors in three distinct scenarios: primary resistance, secondary resistance, and progression after treatment discontinuation. The taskforce generated consensus on several key issues such as the timeframes that delineate each type of resistance, the necessity for confirmatory scans, and identified caveats for each specific resistance classification. The goal of this effort is to provide guidance for clinical trial design and to support analyses of emerging molecular and cellular data surrounding mechanisms of resistance.</span></p> <p style="padding-left: 40px;"><span style="font-size: 12pt;"><strong>Read the full article in <em>JITC</em></strong>: <a href="https://jitc.bmj.com/content/8/1/e000398?utm_source=society&utm_medium=referral&utm_campaign=usage&utm_content=americas-society&utm_term=sitc" target="_blank" id="OWAe6849a05-8486-5cc1-90de-1e56c877f34f" class="OWAAutoLink" rel="noopener">Defining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC Immunotherapy Resistance Taskforce</a></span></p> <p style="padding-left: 80px;"></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-heading container"><div class="HtmlContent"><h3>Immune Checkpoint Inhibitor Combinations Resistance Definitions</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"><div class="HtmlContent"><p style="padding-left: 40px;"><span style="font-size: 12pt;">Immunotherapy is the standard of care for several cancers and the field continues to advance at a rapid pace, with novel combinations leading to indications in an increasing number of disease settings. Durable responses and long-term survival with immunotherapy have been demonstrated in some patients, though lack of initial benefit and recurrence after extended disease control remain major hurdles for the field. Many new combination regimens are in development for patients whose disease progressed on initial immunotherapy. To guide clinical trial design and support analyses of emerging molecular and cellular data surrounding mechanisms of resistance, the Society for Immunotherapy of Cancer (SITC) previously generated consensus clinical definitions for resistance to single-agent anti-PD-1 immune checkpoint inhibitors (ICIs) in three distinct scenarios: primary resistance, secondary resistance, and progression after treatment discontinuation. An unmet need still exists, however, for definitions of resistance to ICI-based combinations, which represent an expanding frontier in the immunotherapy treatment landscape. In 2021, SITC convened a workshop including stakeholders from academia, industry, and government to develop consensus definitions for resistance to ICI-based combination regimens for improved outcome assessment, trial design and drug development. This manuscript reports the minimum drug exposure requirements and time frame for progression that define resistance in both the metastatic setting and the perioperative setting, as well as key caveats and areas for future research with ICI/ICI combinations. Definitions for resistance to ICIs in combination with chemotherapy and targeted therapy will be published in companion volumes to this paper.</span></p> <p style="padding-left: 40px;"><span style="font-size: 12pt;"><strong>Read the full article in <em>JITC</em></strong>: <a href="https://jitc.bmj.com/content/11/3/e005921?utm_source=society&utm_medium=referral&utm_campaign=usage&utm_content=americas-society&utm_term=sitc" target="_blank" id="OWA82b62b7a-8a4f-f2d0-afd0-c0d70608e65d" class="OWAAutoLink" rel="noopener">Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors</a></span></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-heading container"><div class="HtmlContent"><h3>Immune Checkpoint Inhibitor & Chemotherapy Combinations Resistance Definitions</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"><div class="HtmlContent"><p style="padding-left: 40px;"><span style="font-size: 12pt;">Although immunotherapy can offer profound clinical benefit for patients with a variety of difficult-to-treat cancers, many tumors either do not respond to upfront treatment with immune checkpoint inhibitors (ICIs) or progressive/recurrent disease occurs after an interval of initial control. Improved response rates have been demonstrated with the addition of ICIs to cytotoxic therapies, leading to approvals from the US Food and Drug Administration and regulatory agencies in other countries for ICI鈭抍hemotherapy combinations in a number of solid tumor indications, including breast, head and neck, gastric, and lung cancer. Designing trials for patients with tumors that do not respond or stop responding to treatment with immunotherapy combinations, however, is challenging without uniform definitions of resistance. Previously, the Society for Immunotherapy of Cancer (SITC) published consensus definitions for resistance to single-agent anti-programmed cell death protein 1 (PD-1). To provide guidance for clinical trial design and to support analyses of emerging molecular and cellular data surrounding mechanisms of resistance to ICI-based combinations, SITC convened a follow-up workshop in 2021 to develop consensus definitions for resistance to multiagent ICI combinations. This manuscript reports the consensus clinical definitions for combinations of ICIs and chemotherapies. Definitions for resistance to ICIs in combination with targeted therapies and with other ICIs will be published in companion volumes to this paper.</span></p> <p style="padding-left: 40px;"><span style="font-size: 12pt;"><strong>Read the full article in <em>JITC</em></strong>: <a href="https://jitc.bmj.com/content/11/3/e005920?utm_source=society&utm_medium=referral&utm_campaign=usage&utm_content=americas-society&utm_term=sitc" target="_blank" id="OWA738d1ea5-6f94-5794-b443-fdcc50a70ab6" class="OWAAutoLink" rel="noopener">Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors with chemotherapy</a></span></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-heading container"><div class="HtmlContent"><h3>Immune Checkpoint Inhibitor & Targeted Therapy Combinations Resistance Definitions</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"><div class="HtmlContent"><p style="padding-left: 40px;"><span style="font-size: 12pt;">Immunotherapy offers deep and durable disease control to some patients, but many tumors do not respond to treatment with single-agent immune checkpoint inhibitors (ICIs). One strategy to enhance responses to immunotherapy is via combinations with signal transduction inhibitors, such as antiangiogenic therapies, which not only directly target cancer cells but also could potentially favorably modulate the tumor immune microenvironment. Combination strategies with ICIs have demonstrated enhanced antitumor activity compared with tumor-targeted or antiangiogenic therapy alone in randomized trials in a variety of solid tumor settings, leading to regulatory approval from the US Food and Drug Administration and agencies in other countries for the treatment of endometrial cancer, kidney cancer, melanoma, and hepatocellular carcinoma. Despite improved survival and response rates for some patients when antiangiogenic or targeted therapies are administered with ICIs, many patients continue to progress after combination treatment and urgently need new strategies to address this manifestation of resistance to immunotherapy. Previously, the Society for Immunotherapy of Cancer (SITC) published consensus definitions for resistance to single-agent anti-PD-(L)1. To provide guidance for clinical trial design and to support analyses of emerging molecular and immune profiling data surrounding mechanisms of resistance to ICI-based combinations, SITC convened a follow-up workshop in 2021 to develop consensus definitions for resistance to multiagent ICI combinations. This manuscript reports the consensus clinical definitions for combinations of anti-PD-(L)1 ICIs and targeted therapies. Definitions for resistance to ICIs in combination with chemotherapy and with other ICIs will be published in companion volumes to this paper.</span></p> <p style="padding-left: 40px;"><span style="font-size: 12pt;"><strong>Read the full article in <em>JITC</em></strong>: <a href="https://jitc.bmj.com/content/11/3/e005923?utm_source=society&utm_medium=referral&utm_campaign=usage&utm_content=americas-society&utm_term=sitc" target="_blank" id="OWA0d20d694-e63e-347f-6b09-904bb35138f1" class="OWAAutoLink" rel="noopener">Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors with targeted therapies</a></span></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-heading container"><div class="HtmlContent"><h3>Efforts to Harmonize Resistance Definitions</h3></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml accordion-text"><div class="HtmlContent"><p style="padding-left: 40px;"><span style="font-size: 12pt;">The need for solid clinical definitions of resistance to programmed death 1 or its ligand (PD-(L)1) inhibitors for clinical trial design was identified as a priority by the Society for Immunotherapy of Cancer (SITC). Broad consensus efforts have provided definitions for primary and secondary resistance and resistance after stopping therapy for both single-agent PD-(L)1 inhibitors and associated combinations. Validation of SITC鈥檚 definitions is critical and requires field-wide data sharing and collaboration. Here, in this commentary, we detail current utility and incorporation of SITC鈥檚 definitions and discuss the next steps both the society and the field must take to further advance immuno-oncology drug development.</span></p> <p style="padding-left: 40px;"><span style="font-size: 12pt;"><strong>Read the full article in<em> JITC</em></strong>: <a href="https://jitc.bmj.com/content/11/7/e007309?utm_source=society&utm_medium=referral&utm_campaign=usage&utm_content=americas-society&utm_term=sitc" target="_blank" id="OWA7f136364-0dec-f57e-9dc1-edb306d71031" class="OWAAutoLink" rel="noopener">Society for Immunotherapy of Cancer (SITC) checkpoint inhibitor resistance definitions: efforts to harmonize terminology and accelerate immuno-oncology drug development</a></span></p></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section10"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"><a id="committee"></a></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section11"><div class="ContentItemHtml"><div class="HtmlContent"><h2><strong><a id="crisis-organizers" target="_blank"></a>Immunotherapy Resistance Committee</strong></h2></div><div class="HtmlFooter"></div></div></div></div><div class="row row-full "><div class="col-md-12 section12"><div class="ContentItemHtml"><div class="HtmlContent"><style> * { box-sizing: border-box; } .organizercards-container { display: flex; justify-content: center; flex-wrap: wrap; width: 100%; padding: 10px 10px; } .organizercards { /*box-shadow: 0 4px 8px 0 rgba(0,0,0,0.2);*/ transition: 0.3s; flex: 25%; background-color: white; margin: 10px 10px; float: left; max-width: 150px; height: auto; /*border-bottom: 4px solid #1D4F91;*/ } .organizercards img { border-radius: 5px 5px 0px 0px; object-fit: cover; max-width: 150px; height: 150px; position: relative; border-bottom: 4px solid #63A70B; } .organizercards-text { padding: 5px; word-wrap: break-word; align: center; } .organizercards h4 { font-size: 10pt; margin: 4px 0px } /* Responsive layout - makes a one column-layout instead of a two-column layout */ @media (max-width: 850px) { .organizercards { flex: 50%; } } @media (max-width: 500px) { .organizercards { flex: 100%; } } </style> <div class="organizercards-container"> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Sullivan__Ryan_.jpg" alt="Ryan Sullivan, MD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong><span style="color: rgb(21, 78, 143);">Chair</span><br><strong>Ryan Sullivan, MD</strong><br></strong><em>Massachusetts General Hospital</em></h4> <strong> </strong></div> <strong> </strong></div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Kluger__Harriet.jpg" alt="Harriet Kluger, MD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong><span style="color: rgb(21, 78, 143);">Co-Chair</span><br><strong>Harriet Kluger, MD</strong><br></strong><em>Yale Cancer Center</em></h4> <strong> </strong></div> <strong> </strong></div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Tawbi__Hussein_Headshot_2020.jpg" alt="Hussein Tawbi, MD PhD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong><span style="color: rgb(21, 78, 143);">Co-Chair<br></span></strong><strong>Hussein Tawbi, MD PhD</strong><br><em>The University of Texas MD Anderson Cancer Center</em></h4> <strong> </strong></div> <strong> </strong></div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Feltquate__David_2024.jpg" alt="David Feltquate, MD, PhD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong><span style="color: rgb(21, 78, 143);">Co-Chair</span><br><strong>David Feltquate, MD, PhD</strong><br></strong><em>Palleon Pharmaceuticals</em></h4> <strong> </strong></div> <strong> </strong></div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/LaVallee__Theresa.jpg" alt="Theresa LaVallee, PhD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong>Theresa LaVallee, PhD</strong><br><em>Coherus Biosciences</em></h4> </div> </div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Rizvi__Naiyer.jpg" alt="Naiyer Rizvi, MD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong>Naiyer Rizvi, MD</strong><br><em>Synthekine</em></h4> </div> </div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Snyder__Alexandra_2022.png" alt="Alexandra Snyder, MD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong>Alexandra Snyder, MD</strong><br><em>Generate Biomedicines</em></h4> </div> </div> <div class="organizercards"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Sosman__Jeffrey.jpg" alt="Jeffrey Sosman, MD" style="width: 100%;" class="img-responsive"> <div class="organizercards-text"> <h4><strong>Jeffrey Sosman, MD</strong><br><em>Northwestern Medicine</em></h4> </div> </div> <div class="organizercards"></div> </div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section13"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div></div></div><div class="row row-wide clearfix "><div class="col-md-12 section14"><div class="ContentItemHtml"> <div class="HtmlContent"><div style="padding-top: 55px;"></div></div><div class="HtmlFooter"></div></div></div></div> <div id="MainCopy_extraPanel"> </div> </div> </div>  </div> </div> <div id="MPOuterFooter" class="row siteFrame"> <div id="FOOTER" class="col-md-12"> <div class="row row-wide clearfix "><div class="col-md-12 section1"><div class="ContentItemHtml col-md-3"> <div class="HtmlContent"><p style="text-align: center;"><img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/Logos/SITC-logo-white.png" style="float: left;"></p> <br></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml col-md-3"> <div class="HtmlContent"><h3 class="editorSelectH3">Membership Links</h3> <p><a href="/membership/join">Join</a></p> <p><a href="https://sitc.execinc.com/edibo/Dues" target="_blank">Renew</a></p> <p><a href="/network/members">Member Directory</a></p> <p><a href="profile">My Profile</a></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml col-md-3"> <div class="HtmlContent"><h3 class="editorSelectH3">Get Involved</h3> <p><a href="https://www.sitcancer.org/subscription" target="_blank" rel="noopener">Email Sign-up</a></p> <p><a href="volunteer">Volunteer</a></p> <p><a href="https://sitc.sitcancer.org/donate/?_ga=2.69149585.1866415943.1648138048-1544668743.1643294471">Support SITC</a></p> <p><a href="https://www.sitcancer.org/aboutsitc/contact-sitc">Contact Us</a></p></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml social-media col-md-3"> <div class="HtmlContent"><p><a href="https://www.facebook.com/sitcancer" target="_blank" rel="noopener noreferrer"> <img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/facebook.png"> </a> <a href="https://twitter.com/sitcancer" target="_blank" rel="noopener noreferrer"> <img src="//higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/TwitterX_Icons_for_Webpage_18px.png"> </a> <a href="https://www.linkedin.com/company/381116" target="_blank" rel="noopener noreferrer"> <img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/linkedin.png"> </a> <a href="http://www.youtube.com/user/SITCancer?feature=watch" target="_blank" rel="noopener noreferrer"> <img src="https://higherlogicdownload.s3.amazonaws.com/SITCANCER/2c19e5a6-3adb-4d01-b46c-c01e11745b3a/UploadedImages/icons/youtube.png"> </a></p></div><div class="HtmlFooter"></div></div></div></div> <div id="MPFooter" class="row"> <div class="Footer col-md-12"> <div id="FooterContent"> </div> <div id="MPBottomMenu" class="MPBottomMenu" align="center"> </div> </div> </div> <div class="row"> <div id="MPCopyright" class="col-md-12"> 漏 2024 Society for Immunotherapy of Cancer (SITC). All rights reserved. </div> </div> <div class="row row-wide clearfix "><div class="col-md-12 section1"><div class="ContentItemHtml col-md-6 sub-footer"> <div class="HtmlContent">555 East Wells Street, Suite 1100 | Milwaukee, WI | 53202-3823 | USA <br></div><div class="HtmlFooter"></div></div><div class="ContentItemHtml col-md-6 sub-footer"> <div class="HtmlContent"><p style="text-align: right;">Tel: +1 414 271 2456 | Fax: +1 414 276 3349 | Email: <a href="mailto:info@sitcancer.org">info@sitcancer.org</a></p></div><div class="HtmlFooter"></div></div><div class="ContentUserControl"> <script charset="utf-8" src="http://dthis.com/js/300/addthis_widget.js#pubid=ra-586d5f6453e2f81d"></script> </div><div class="ContentItemHtml"> <div class="HtmlContent"><script type="text/javascript"> _linkedin_partner_id = "2569393"; window._linkedin_data_partner_ids = window._linkedin_data_partner_ids || []; window._linkedin_data_partner_ids.push(_linkedin_partner_id); </script> <script type="text/javascript"> (function(l) { if (!l){window.lintrk = function(a,b){window.lintrk.q.push([a,b])}; window.lintrk.q=[]} var s = document.getElementsByTagName("script")[0]; var b = document.createElement("script"); b.type = "text/javascript";b.async = true; b.src = "https://snap.licdn.com/li.lms-analytics/insight.min.js"; s.parentNode.insertBefore(b, s);})(window.lintrk); </script> <noscript> <img height="1" width="1" style="display:none;" alt="" src="https://px.ads.linkedin.com/collect/?pid=2569393&fmt=gif" /> </noscript></div><div class="HtmlFooter"></div></div></div></div> <div class="row"> <div class="col-md-12"></div> </div> </div> </div> <div id="MPFooterLink" class="row siteFrame"> <div class="col-md-12"> <div id="MPFooterLinkContent"> <a href="http://www.higherlogic.com" target="_blank">Powered by Higher Logic</a> </div> </div> </div> <div id="GlobalPopupContainer"> <div id="GlobalPopupContent" > <img ID="imgGlobalProcessing" alt="" src="https://d2x5ku95bkycr3.cloudfront.net/img/loading.gif" /> </div> </div> <script type="text/javascript"> //<![CDATA[ var _suppressGlobalPopupContainer = false; Sys.Application.add_load(GlobalApplicationLoadHandler); function GlobalApplicationLoadHandler(sender, args) { var prm = Sys.WebForms.PageRequestManager.getInstance(); if (!prm.get_isInAsyncPostBack()) { prm.add_initializeRequest(initRequest); prm.add_endRequest(endRequest); } } function initRequest(sender, args) { if (!_suppressGlobalPopupContainer) { hl_common_ui_blockUI(); } } function endRequest(sender, args) { hl_common_ui_unBlockUI(); }//]]> </script> <script type='text/javascript'>new Sys.WebForms.Menu({ element: 'AuxMenu', disappearAfter: 500, orientation: 'horizontal', tabIndex: 0, disabled: false });</script></form> </div> <script> $(document).ready(function () { var path = window.location.pathname; var lastChar = path.substr(-1); // Selects the last character if (lastChar != '?' && lastChar != '/' && lastChar != ';') { // If the last character is not a slash path = path + '/'; // Append a slash to it. } $('ul.navbar-nav a').each(function () { var myHref = $(this).attr('href').split("?")[0]; var lastChar2 = myHref.substr(-1); // Selects the last character if (lastChar2 != '?' && lastChar2 != '/' && lastChar2 != ';') { // If the last character is not a slash myHref = myHref + '/'; // Append a slash to it. } if (path == myHref) { $(this).parents('li').last().addClass('active current-page'); $(this).parent('li').addClass('active current-page'); } }); $('#modalTags').on('tagAdded', function () { var oldCount = parseInt($('#litCommunityTagsCount').text()); $('#litCommunityTagsCount').text(oldCount + 1); }).on('tagRemoved', function () { var oldCount = parseInt($('#litCommunityTagsCount').text()); $('#litCommunityTagsCount').text(oldCount - 1); }); var isImpersonating = false; }); //var btn = $.fn.button.noConflict(); // reverts $.fn.button to jqueryui btn //$.fn.btn = btn; // assigns bootstrap button functionality to $.fn.btn </script> </body> </html>