TAME - Targeting Aging with Metformin - American Federation for Aging Research

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inlay__bg--block-792583"></div> <style> .inlay__bg--block-792583 { background-image: url(/imager/sciencebackgroundphotos/375125/TAME_GreenHalfTone_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-792583 { background-image: url(/imager/sciencebackgroundphotos/375125/TAME_GreenHalfTone_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-792583 { background-image: url(/imager/sciencebackgroundphotos/375125/TAME_GreenHalfTone_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--img component__bgimg poster inlay__bg--block-792583"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h4>The TAME Trial</h4><h1>Targeting the Biology of Aging.<br />Ushering a New Era of Interventions.</h1><p>The official web resource of the TAME Trial, managed by the American Federation for Aging Research.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-top section--padxs-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/398442/FemalePatient_Prescription_Doctor_TAME_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Female Patient Prescription Doctor TAME"> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>What is the TAME Trial?</h2><h4>The Targeting Aging with Metformin (TAME) Trial is a series of nationwide, six-year clinical trials at 14 leading research institutions across the country that will engage over 3,000 individuals between the ages of 65-79.<br /></h4><p>Wake Forest University School of Medicine will be the coordinating center. These trials will test whether those taking metformin experience delayed development or progression of age-related chronic diseases—such as heart disease, cancer, and dementia.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--padxs-top section--padxs-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Why Metformin?<br /></h2><p>Metformin is an FDA-approved drug used successfully to treat diabetes for more than 60 years.</p><p>Studies have already shown that metformin can delay aging in animals. It may also influence fundamental aging factors that underlie multiple age-related conditions in humans.</p><p><strong>While other promising drugs are in trials to target aging, Metformin is the focus of the TAME at the recommendation of NIH-funded Geroscience Network because of its safety and low cost.</strong></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--padxs-top section--padxs-bottom section--bgclr color-green section--bgimg text-center"> <div class="section__bg section__bg--img poster inlay__bg--block-792595"></div> <style> .inlay__bg--block-792595 { background-image: url(/imager/sciencebackgroundphotos/216998/MoleculesGlow_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-792595 { background-image: url(/imager/sciencebackgroundphotos/216998/MoleculesGlow_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-792595 { background-image: url(/imager/sciencebackgroundphotos/216998/MoleculesGlow_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid "> <div class="grid__inner"> <div class="grid-item section__offset section__offset--sm"> <div class="component component--inherit"> <div class="stat"> <div class="stat__value"> <div class="counter"> <h2 class="counter__value js-count" data-number="14">14</h2> </div> </div> <div class="separator"></div> <div class="stat__cdontent" data-aos="fade-up"> <h4 class="stat__title ">Trial sites</h4> </div> </div> </div> </div> <div class="grid-item section__offset section__offset--sm"> <div class="component component--inherit"> <div class="stat"> <div class="stat__value"> <div class="counter"> <h2 class="counter__value js-count" data-number="6">6</h2> </div> </div> <div class="separator"></div> <div class="stat__cdontent" data-aos="fade-up"> <h4 class="stat__title ">Years of trials, once launched</h4> </div> </div> </div> </div> <div class="grid-item section__offset section__offset--sm"> <div class="component component--inherit"> <div class="stat"> <div class="stat__value"> <div class="counter"> <h2 class="counter__value js-count" data-number="3000">3000</h2> </div> </div> <div class="separator"></div> <div class="stat__cdontent" data-aos="fade-up"> <h4 class="stat__title ">Participants, ages 65-79, to be engaged</h4> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padsm-top "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h5>Opportunity</h5><h3>Proving Aging is Treatable</h3><p>The TAME (Targeting Aging with Metformin) Trial will establish a clinical trial to provide proof-of-concept that aging can be treated, just as we treat diseases.</p><p>Studies show that metformin may influence metabolic and cellular processes that are associated with the development of age-related conditions. Metformin and other drugs in development are expected to delay the onset of these major diseases.</p> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/13100/AgingDiseasePieCircle_13be473ce301a9d01544a6be29bb1011.jpg" alt="Aging Disease Pie Circle Original"> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h5>Goal</h5><h3>Earning a Treatment "Indication"</h3><p>We hope the FDA will approve aging as an indication, to signify that aging can be “treated.” In medical terms, an “indication” for a drug refers to the use of that drug for treating a particular condition.</p><p>If aging is made an indication, the TAME Trial will mark a paradigm shift: from treating each age-related medical condition separately, to treating these conditions together, by targeting aging per se.</p> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/143780/tame-graphic-indication_8c3db02c789aac09497d19c3bbf7ce48.png" alt="Tame graphic indication"> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--band section--padxs-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h5>Need</h5><h3>Raising Funds to Launch</h3><p>AFAR is leading fundraising efforts to support and launch the TAME Trial. Targeting aging and age-related diseases through drug interventions holds the promise of extending years of health while saving trillions of dollars.</p> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item grid-item--card-wide"> <div class="component "> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/218233/DollarSignMolecules_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Dollar Sign Molecules"> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padsm-top section--padsm-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="cta cta--big cta--stretch-image"> <div class="shadow"></div> <div class="component component--nocaption cta__image lazyload" data-bgset="/imager/general/440523/Breakthroughs-Abstract-HighRes-copy_5a84b14c3dbf4df7d609c2160e5728e6.jpg [(max-width: 767px)], /imager/general/440523/Breakthroughs-Abstract-HighRes-copy_b5223c3a18dd2e6dd7e6d9f9af88120e.jpg [(max-width: 1023px)], /imager/general/440523/Breakthroughs-Abstract-HighRes-copy_b5223c3a18dd2e6dd7e6d9f9af88120e.jpg"> </div> <div class="component cta__content"> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article"> <div class="article__inner"> <div class="article__main" data-aos="fade-up"> <h3>TAME Trial Updates</h3><p>Stay connected to learn more about participating in the TAME Trial and to receive updates on its progress and launch.<br /></p> </div> <div class="article__aside cta-button" data-aos="fade-up"> <div class="article__actions"> <a href="https://app.e2ma.net/app2/audience/signup/1922217/1724540/" class="btn" target="block.button.getTarget()"> <span class="btn__background"></span> <span class="btn__content">Sign up for TAME Trial Updates</span> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bgclr color-blue "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit component--center"> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h2>Can We Grow Older Without Getting Sicker?</h2> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padxs-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="section__cols"> <div class="section__main"> <div class="component"> <div class="inlay"> <div class="inlay__inner"> <div class="article article--avatar article--avatarwrap color-blue"> <div class="article__inner component__cols"> <div class="article__main clear"> <div class="article__content" data-aos="fade-up"> <h3>TAME Trial Media Highlights</h3><p>From JAMA to CNN, the Wall Street Journal to Science, the TODAY show to WIRED and The New York Times, the TAME (Targeting Aging with Metformin) Trial has received widespread attention in both scientific journals and popular media worldwide.</p><p>Scroll through media highlights <strong>at </strong><strong>right.</strong></p> <div class="socials"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sidebar sidebar--big"> <div class="slider slider--embed slider--color color-green"> <div class="slider__intro text-center"> <div class="shadow"></div> <h5>TAME TRIAL in The News</h5> </div> <div class="slider__inner"> <div class="grid swiper-container js-slider-embed"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component 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12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <p><strong>"Finding a Drug for Healthy Aging"</strong></p> </div> <div class="swiper-pagination"></div> </div> <a href="https://well.blogs.nytimes.com/2016/02/01/pursuing-the-dream-of-healthy-aging/" class="card__link component__link" target="_blank"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card"> <div class="shadow"></div> <div class="card__image"> <img class="lazyload" data-src="/imager/general/351731/TAME-Media-Highlight_WallStreetJournal_f7a9bdabdac5f4ef029b9375b1a4069f.jpg" alt="TAME Media Highlight Wall Street Journal"> <div class="slider-nav slider-nav--inset"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" 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</span> </div> </div> </div> <div class="card__inner"> <div class="card__content"> <p><strong>Is Aging a Disease You Can Reverse? A Look at the Science Behind the Longevity Movement </strong></p> </div> <div class="swiper-pagination"></div> </div> <a href="https://www.vogue.com/article/how-to-live-longer-longevity" class="card__link component__link" target="_blank"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bgclr color-blue "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component component--inherit component--center"> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h1>What is the status of the TAME Trial?</h1> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--padxs-top section--padsm-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid"> <div class="grid__inner"> <div class="grid-item"> <div class="component component--nocaption "> <div class="inlay"> <div class="inlay__inner"> <div class="article article--photo color-blue"> <div class="article__inner component__cols"> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/386952/Tame-Status2_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Tame Status2"> </div> </div> </div> <div class="article__main" data-aos="fade-up"> <p><strong>WHAT'S READY</strong><br />Study design has been expertly prepared by a scientific advisory committee.</p><p>Dozens of promising drug interventions—many of which have been developed by AFAR-supported scientists—are ready to enter the market.</p> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item"> <div class="component component--nocaption "> <div class="inlay"> <div class="inlay__inner"> <div class="article article--photo color-blue"> <div class="article__inner component__cols"> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/386953/Tame-Status_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Tame Status"> </div> </div> </div> <div class="article__main" data-aos="fade-up"> <p><strong>WHAT'S NEEDED</strong><br />Visionary donors to help launch the multi-year, multi-site TAME Trial.</p><p>3,000 individuals between the ages of 65-79 to participate.<br /><br />An "indication" for aging. With an "indication" for aging, we can target the biology of aging and thereby delay age-related disease.</p> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item"> <div class="component component--nocaption "> <div class="inlay"> <div class="inlay__inner"> <div class="article article--photo color-blue"> <div class="article__inner component__cols"> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/healthyaging/386954/Tame-Status3_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Tame Status3"> </div> </div> </div> <div class="article__main" data-aos="fade-up"> <p><strong>WHAT'S AHEAD</strong><strong><br /></strong>More years of health and vitality for us all.<br /><br />If the TAME Trial is successful, and aging is made an indication for treatment, a new era of treatments will be available.<br /><br />An indication for aging also creates new opportunities for biotech innovation and investment.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--bigbar section--padxs-top section--padsm-bottom"> <div class="section__inner section__pad"> <div class="shell"> <div class="cta cta--big cta--stretch-image"> <div class="shadow"></div> <div class="component component--bgclr color-purple component--nocaption cta__image lazyload" data-bgset="/imager/healthyaging/63565/MultiGenFamily_Cauc_5a84b14c3dbf4df7d609c2160e5728e6.jpg [(max-width: 767px)], /imager/healthyaging/63565/MultiGenFamily_Cauc_b5223c3a18dd2e6dd7e6d9f9af88120e.jpg [(max-width: 1023px)], /imager/healthyaging/63565/MultiGenFamily_Cauc_b5223c3a18dd2e6dd7e6d9f9af88120e.jpg"> </div> <div class="component component--bgclr component__bgclr color-purple cta__content"> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article"> <div class="article__inner"> <div class="article__main" data-aos="fade-up"> <h1>Revolutionize the Future <br />of Healthy Aging</h1><p> AFAR welcomes the opportunity to discuss with you ways to sponsor the TAME Trial. 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TAME - Targeting Aging with Metformin - American Federation for Aging Research