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Mining NGS repertoires to pick better binders
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data-elementor-type="wp-page" data-elementor-id="6217" class="elementor elementor-6217"> <div class="elementor-element elementor-element-6246229 e-flex e-con-boxed e-con e-parent" data-id="6246229" data-element_type="container"> <div data-rocket-location-hash="547ec2470d2bda10abb0f19dcabad963" class="e-con-inner"> </div> </div> <section class="elementor-section elementor-top-section elementor-element elementor-element-5ea33a4 elementor-section-full_width container pb-5 mb-md-2 mb-lg-4 elementor-section-height-default elementor-section-height-default" data-id="5ea33a4" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-64e7138" data-id="64e7138" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-948d555 elementor-widget elementor-widget-highlighted-heading" data-id="948d555" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h1 class="silicon-elementor-highlighted-heading__title border-bottom pb-4"><span class="silicon-elementor-highlighted-heading__highlighted-text text-gradient-primary">Antibody hit expansion</span></h1> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-692fb93 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="692fb93" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row pt-2 pt-md-3 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9540ead col-md-6" data-id="9540ead" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-59b6734 elementor-widget elementor-widget-highlighted-heading" data-id="59b6734" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg pe-lg-4 mb-1 mb-lg-4"><span class="si-multipurpose-text__before">Immune repertoires contain greater diversity than screening methods can interrogate. Moreover, any selection, panning, or filtering process often have biases or limitations that exclude valuable antibodies. High-throughput sequencing allows discovery teams to expand hits to millions of clones and extend the limits of screening technologies. Among this larger pool of clones desirable properties like liability-free proteins or high thermostabilities can be selected for amongst the right affinity and function.</span></p> </div> </div> <div class="elementor-element elementor-element-07f09f2 elementor-widget elementor-widget-button" data-id="07f09f2" data-element_type="widget" data-widget_type="button.button-silicon"> <div class="elementor-widget-container"> <a class="shadow-primary silicon-button btn btn-primary btn-lg mb-1" href="https://enpicom.com/request-a-demo/" role="button"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text silicon-button-text order-last">Book a demo</span> </span> </a> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8888aa8 col-md-6" data-id="8888aa8" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element 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elementor-element elementor-element-6c40640b elementor-section-full_width container pb-5 mb-md-2 mb-lg-4 elementor-section-height-default elementor-section-height-default" data-id="6c40640b" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3035d2df" data-id="3035d2df" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-32d9c6d9 elementor-widget elementor-widget-highlighted-heading" data-id="32d9c6d9" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title border-bottom pb-4"><span class="si-multipurpose-text__before">Mining NGS repertoires to pick better binders with optimal developability profiles</span></h2> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-76fbb74f elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="76fbb74f" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row pt-2 pt-md-3 row-margin"> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6c9f95c col-md-6" data-id="6c9f95c" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-66d59b1d elementor-widget elementor-widget-highlighted-heading" data-id="66d59b1d" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg pe-lg-4 mb-1 mb-lg-4"><span class="si-multipurpose-text__before">Traditionally, hybridoma discovery workflows rely on the expression of a limited number of antibody candidates for testing with laboratory assays. Single B cell screening protocols and technologies like the Beacon can interrogate hundreds to thousands of clones. These approaches provide a small selection of well-characterized antibodies but unavoidably miss many antibodies with potentially better properties in a immune or synthetic repertoire. Antibodies not captured in immunization with similar sequences to known binders might have higher affinity, better thermostability or solubility, or less developmental liabilities. Combining these well-characterized antibody sequences with larger bulk-NGS or paired-chain sequencing approaches (e.g., 10x Genomics) enables researchers to expand and diversify the candidate pool and find better antibodies missed upon selection.</span></p> </div> </div> </div> </div> <div class="elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4bcefc36 col-md-6" data-id="4bcefc36" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-48b2f2cd elementor-widget elementor-widget-highlighted-heading" data-id="48b2f2cd" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <p class="silicon-elementor-highlighted-heading__title fs-lg pe-lg-4 mb-1 mb-lg-4"><span class="si-multipurpose-text__before">This expansion into a larger repertoire is especially relevant in in-vivo immunization or disease approaches where the animal/subject鈥檚 immune system works to generate the best antibodies against a given target. The lineages generated can be used to understand the antibody evolution and select the best candidates generated. Furthermore, mutations in this evolutionary branches can be combined to obtain synergies in binding strength yielding antibodies with superior properties than those naturally generated.</span></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-0e5047c elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="0e5047c" data-element_type="section"> <div class="elementor-container elementor-column-gap-default container mb-5 pb-lg-5 pb-md-4 pb-3"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-395cfa0" data-id="395cfa0" data-element_type="column"> <div class="p-0 elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9da1615 elementor-widget elementor-widget-highlighted-heading" data-id="9da1615" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title h2 mb-lg-5 mb-4 pb-lg-0 pb-md-2 text-center"><span class="si-multipurpose-text__before">Antibody discovery simplified</span></h2> </div> </div> <div class="elementor-element elementor-element-bf546e3 elementor-widget elementor-widget-sn-imagebox-carousel" data-id="bf546e3" data-element_type="widget" data-settings="{"autoplay_speed":3000,"effect":"slide","speed":500,"autoplay":"yes","pause_on_hover":"yes"}" data-widget_type="sn-imagebox-carousel.imagebox-carousel"> <div class="elementor-widget-container"> <div data-swiper-options="{"spaceBetween":24,"pagination":{"el":".swiper-pagination","type":"bullets","clickable":true},"breakpoints":{"600":{"slidesPerView":3},"1000":{"slidesPerView":4}},"autoplay":{"delay":3000,"pauseOnMouseEnter":true},"speed":500}" class="swiper sn-elementor-main-swiper mb-xl-3 "> <div class="swiper-wrapper"> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="description_24dp_3563F9" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/description_24dp_3563F9.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/description_24dp_3563F9.svg" width="32" alt="description_24dp_3563F9" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: #221F20">Accurate repertoire processing and annotation </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Profile any NGS or paired chain data (using barcodes, linkers or clone/well identifiers) and annotate all relevant regions and affinity maturation (SHM).</p></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="manage_search_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/manage_search_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/manage_search_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="manage_search_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: #221F20">A 360 view of your data </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Import assay data (metadata) of characterized antibodies with their sequences.</p></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <div class="silicon-elementor-svg-wrapper"><svg xmlns="http://www.w3.org/2000/svg" height="24px" viewBox="0 -960 960 960" width="24px" fill="#3563f9"><path d="M760-600q-57 0-99-34t-56-86H354q-11 42-41.5 72.5T240-606v251q52 14 86 56t34 99q0 66-47 113T200-40q-66 0-113-47T40-200q0-57 34-99t86-56v-251q-52-14-86-56t-34-98q0-66 47-113t113-47q56 0 98 34t56 86h251q14-52 56-86t99-34q66 0 113 47t47 113q0 66-47 113t-113 47ZM200-120q33 0 56.5-24t23.5-56q0-33-23.5-56.5T200-280q-32 0-56 23.5T120-200q0 32 24 56t56 24Zm0-560q33 0 56.5-23.5T280-760q0-33-23.5-56.5T200-840q-32 0-56 23.5T120-760q0 33 24 56.5t56 23.5ZM760-40q-66 0-113-47t-47-113q0-66 47-113t113-47q66 0 113 47t47 113q0 66-47 113T760-40Zm0-80q33 0 56.5-24t23.5-56q0-33-23.5-56.5T760-280q-33 0-56.5 23.5T680-200q0 32 23.5 56t56.5 24Zm0-560q33 0 56.5-23.5T840-760q0-33-23.5-56.5T760-840q-33 0-56.5 23.5T680-760q0 33 23.5 56.5T760-680ZM200-200Zm0-560Zm560 560Zm0-560Z"></path></svg></div> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: #221F20">Combining all datasets </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Cluster bulk NGS or single-cell barcoded data with Sanger sequences of characterized antibodies based on sequence similarity and other immunologically relevant features.</p></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="search_insights_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/search_insights_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/search_insights_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="search_insights_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: #221F20">Easily identify clusters of interest </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Select clusters where known binders are present and prioritize them using the metadata linked to the characterized sequences.</p></div></div></div></div></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="star_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/star_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/star_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="star_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: #221F20">Antibody developability assessment </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><section class=" cards alignleft default "><div class="container"><div class="collection collection--cards"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Use high-throughput structural modeling to predict exposed liabilities and assess the developability of candidates with confidence and ease.</p></div></div></div></div></div></div></section></div> </div> </div> </div> <div class="swiper-slide h-auto "> <div class="h-100 card text-center "> <div class="card-body my-md-5 my-4 py-xl-2 py-md-0 py-sm-2 text-center"> <div class="d-table position-relative d-block mx-auto mb-3"> <img decoding="async" class="" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2032%200'%3E%3C/svg%3E" width="32" alt="allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style="" data-lazy-src="https://enpicom.com/wp-content/uploads/2024/09/allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg"><noscript><img decoding="async" class="" src="https://enpicom.com/wp-content/uploads/2024/09/allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24.svg" width="32" alt="allergies_24dp_3563F9_FILL0_wght400_GRAD0_opsz24" style=""></noscript> </div> <h3 class="si-imagebox-title h5 mb-3" style="color: #221F20">Maximum insights </h3> <div class="si-imagebox-description mb-0-last-child" style="color: #221F20"><section class=" cards alignleft default "><div class="container"><div class="collection collection--cards"><div class="m-card m-card--boxed" data-type="custom"><div class="content"><p>Explore lineages of interest to identify antibody candidates with desired characteristics (e.g., higher affinity maturation or fewer liabilities) and interesting mutations).</p></div></div></div></div></section></div> </div> </div> </div> </div> <div class="swiper-pagination position-static mt-4 pt-lg-3 pt-2"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-3a047e0 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="3a047e0" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9e04f7c" data-id="9e04f7c" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4156d3c elementor-widget__width-initial elementor-widget elementor-widget-heading" data-id="4156d3c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">How it works</h2> </div> </div> <div class="elementor-element elementor-element-97942c9 elementor-icon-list--layout-inline elementor-align-center elementor-tablet-align-center elementor-mobile-align-left elementor-widget-tablet__width-initial elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list" data-id="97942c9" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="elementor-icon-list-items elementor-inline-items"> <li class="fs-xl mx-3 mt-2 mt-sm-3 elementor-icon-list-item elementor-inline-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check"></i> </span> <span class="elementor-icon-list-text">Flexible analysis configurations</span> </li> <li class="fs-xl mx-3 mt-2 mt-sm-3 elementor-icon-list-item elementor-inline-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check"></i> </span> <span class="elementor-icon-list-text">Interactive visualizations</span> </li> <li class="fs-xl mx-3 mt-2 mt-sm-3 elementor-icon-list-item elementor-inline-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check"></i> </span> <span class="elementor-icon-list-text">Sophisticated metadata integration</span> </li> <li class="fs-xl mx-3 mt-2 mt-sm-3 elementor-icon-list-item elementor-inline-item"> <span class="elementor-icon-list-icon"> <i aria-hidden="true" class="bx bx-check"></i> </span> <span class="elementor-icon-list-text">Automated workflows</span> </li> </ul> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-60ec796 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="60ec796" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-558afc9" data-id="558afc9" data-element_type="column"> <div class="position-relative elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-86b00bc elementor-widget elementor-widget-image" data-id="86b00bc" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" width="11600" height="4900" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%2011600%204900'%3E%3C/svg%3E" class="rounded-3 shadow-sm attachment-full size-full wp-image-11706" alt="" 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elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f976d4" data-id="3f976d4" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-section elementor-inner-section elementor-element elementor-element-85ed743 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="85ed743" data-element_type="section"> <div class="elementor-container elementor-column-gap-default row justify-content-center text-center"> <div class="elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-cf7d18e" data-id="cf7d18e" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-f753e77 elementor-widget elementor-widget-highlighted-heading" data-id="f753e77" data-element_type="widget" data-widget_type="highlighted-heading.default"> <div class="elementor-widget-container"> <h2 class="silicon-elementor-highlighted-heading__title h2 mb-lg-5 mb-4 pb-lg-0 pb-md-2 text-center"><span class="silicon-elementor-highlighted-heading__highlighted-text text-gradient-primary">Learn more </span><span class="si-multipurpose-text__before">about the most powerful platform for BCR repertoire analysis</span></h2> </div> </div> </div> </div> </div> </div> <div class="elementor-section elementor-inner-section elementor-element elementor-element-d85ec3c elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="d85ec3c" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-b83be72" data-id="b83be72" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-058e60c elementor-widget elementor-widget-spacer" data-id="058e60c" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <div class="elementor-element elementor-element-e6b7fab elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-auto elementor-widget elementor-widget-heading" data-id="e6b7fab" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default"><a href="https://enpicom.com/news/bringing-accurate-liability-assessments-to-antibody-discovery-with-the-igx-platform/">Blog</a></h3> </div> </div> <div class="elementor-element elementor-element-6dbcb51 elementor-widget elementor-widget-heading" data-id="6dbcb51" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default">Accurate developability assessments of antibody candidates</p> </div> </div> <div class="elementor-element elementor-element-da686ca elementor-align-left elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-inherit elementor-widget elementor-widget-button" data-id="da686ca" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://enpicom.com/news/bringing-accurate-liability-assessments-to-antibody-discovery-with-the-igx-platform/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-arrow-right" viewBox="0 0 448 512" xmlns="http://www.w3.org/2000/svg"><path d="M190.5 66.9l22.2-22.2c9.4-9.4 24.6-9.4 33.9 0L441 239c9.4 9.4 9.4 24.6 0 33.9L246.6 467.3c-9.4 9.4-24.6 9.4-33.9 0l-22.2-22.2c-9.5-9.5-9.3-25 .4-34.3L311.4 296H24c-13.3 0-24-10.7-24-24v-32c0-13.3 10.7-24 24-24h287.4L190.9 101.2c-9.8-9.3-10-24.8-.4-34.3z"></path></svg> </span> <span class="elementor-button-text">Learn more</span> </span> </a> </div> </div> </div> <div class="elementor-element elementor-element-07c92f6 elementor-widget elementor-widget-spacer" data-id="07c92f6" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-1b43878" data-id="1b43878" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-32673a5 elementor-widget elementor-widget-spacer" data-id="32673a5" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <div class="elementor-element elementor-element-c70d6bd elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-auto elementor-widget elementor-widget-heading" data-id="c70d6bd" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default"><a href="https://enpicom.com/hit-selection/">Hit selection</a></h3> </div> </div> <div class="elementor-element elementor-element-515f994 elementor-widget elementor-widget-heading" data-id="515f994" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <p class="elementor-heading-title elementor-size-default">Easily integrate any assay data from wet lab experiments and compute structure-based developability profiles in silico to pick the optimal set of antibodies.</p> </div> </div> <div class="elementor-element elementor-element-9fed501 elementor-align-left elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-inherit elementor-widget elementor-widget-button" data-id="9fed501" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-sm" href="https://enpicom.com/hit-selection/"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-icon"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-arrow-right" viewBox="0 0 448 512" xmlns="http://www.w3.org/2000/svg"><path d="M190.5 66.9l22.2-22.2c9.4-9.4 24.6-9.4 33.9 0L441 239c9.4 9.4 9.4 24.6 0 33.9L246.6 467.3c-9.4 9.4-24.6 9.4-33.9 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