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<!DOCTYPE html> <html lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head>  <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="format-detection" content="telephone=no"> <meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=no"> <meta name="description" content="Access full-text academic articles: J-STAGE is an online platform for Japanese academic journals."> <meta name="citation_journal_title" content="Journal of Pharmacological Sciences" /> <meta name="citation_publisher" content="The Japanese Pharmacological Society" /> <meta name="citation_author" content="Hideki Dohmoto" /> <meta name="citation_author_institution" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="citation_author" content="Akira Takahara" /> <meta name="citation_author_institution" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="citation_author" content="Hisayuki Uneyama" /> <meta name="citation_author_institution" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="citation_author" content="Ryota Yoshimoto" /> <meta name="citation_author_institution" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="citation_title" content="Cardiac Ca2+ Channel-Blocking Effects of the Cyproheptadine Derivative AH-1058 in Isolated Guinea Pig Cardiomyocytes" /> <meta name="citation_publication_date" content="2003" /> <meta name="citation_online_date" content="2003/02/20" /> <meta name="citation_volume" content="91" /> <meta name="citation_issue" content="2" /> <meta name="citation_firstpage" content="163" /> <meta name="citation_lastpage" content="166" /> <meta name="citation_doi" content="10.1254/jphs.91.163" /> <meta name="citation_fulltext_world_readable" content="" /> <meta name="citation_pdf_url" content="https://www.jstage.jst.go.jp/article/jphs/91/2/91_2_163/_pdf" /> <meta name="citation_issn" content="1347-8613" /> <meta name="citation_issn" content="1347-8648" /> <meta name="citation_language" content="en" /> <meta name="citation_keywords" content="AH-1058" /> <meta name="citation_keywords" content="cyproheptadine" /> <meta name="citation_keywords" content="L-type Ca2+ current" /> <meta name="citation_reference" content="1 Takahara A, Sugiyama A, Yoshimoto R and Hashimoto K: AH-1058: A novel cardioselective Ca2+ channel blocker. Cardiovasc Drug Rev 19, 279 – 296 (2001)" /> <meta name="citation_reference" content="2 Takahara A, Uneyama H, Sasaki N, Ueda H, Dohmoto H, Shoji M, Hara Y, Nakaya H and Yoshimoto R: Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents. J Cardiovasc Pharmacol 33, 625 – 632 (1999)" /> <meta name="citation_reference" content="3 Tanaka H, Ichikawa T, Matsui S, Okazaki K, Masumiya H, Kawanishi T and Shigenobu K: Calcium channel antagonistic effects of AH-1058, a novel antiarrhythmic drug, on guinea-pig myocardium. Res Commun Mol Pathol Pharmacol 104, 13 – 21 (1999)" /> <meta name="citation_reference" content="4 Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R and Hashimoto K: Antiarrhythmic and cardiohemodynamic effects of a novel Ca2+ channel blocker, AH-1058, assessed in canine arrhythmia models. Eur J Pharmacol 398, 107 – 112 (2000)" /> <meta name="citation_reference" content="5 Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R and Hashimoto K: Comparison of cardiovascular effects of a new calcium channel blocker AH-1058 with those of verapamil assessed in blood-perfused canine heart preparations. J Cardiovasc Pharmacol 35, 741 – 748 (2000)" /> <meta name="citation_reference" content="6 Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R and Hashimoto K: Electrophysiological and cardiohemodynamic effects of a new type of calcium channel blocker AH-1058 assessed by the canine in vivo model. Jpn J Pharmacol 83, 107 – 112 (2000)" /> <meta name="citation_reference" content="7 Takahara A, Dohmoto H, Sugiyama A, Yoshimoto R and Hashimoto K: Cardiovascular action of a cardioselective Ca2+ channel blocker AH-1058 in conscious dogs assessed by telemetry. Eur J Pharmacol 413, 101 – 108 (2001)" /> <meta name="citation_reference" content="8 Takahara A, Dohmoto H, Yoshimoto R, Sugiyama A and Hashimoto K: Utilization of telemetry system to assess the cardiovascular profile of AH-1058, a new cardioselective Ca2+ channel blocker, in conscious dogs. Jpn J Pharmacol 85, 331 – 334 (2001)" /> <meta name="citation_reference" content="9 Winquist RJ, Siegl PKS, Baskin EP, Bohn DL, Morgan G and Wallace AA: Calcium entry blocker activity of cyproheptadine in isolated cardiovascular preparations. J Pharmacol Exp Ther 230, 103 – 109 (1984)" /> <meta name="citation_reference" content="10 Uneyama H, Uchida H, Konda T, Yoshimoto R and Akaike N: Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels. Eur J Pharmacol 373, 93 – 100 (1999)" /> <meta name="citation_reference" content="11 Uneyama H, Uchida H, Maeda K, Yoshimoto R, Watanabe Y and Inoue K: Non-L-type actions of organic Ca2+ channel blockers: implications for Na+ and N-type Ca2+ channel blockades. In Calcium Ion Modulators: The New Wave of Psychotropic Drugs, Edited by Inoue K and Watanabe Y, pp 13 – 23, Harwood Academic Publishers, The Netherlands (1998)" /> <meta name="citation_reference" content="12 Singh PK, Pendse VK and Bhandari DS: Cyproheptadine in ventricular arrhythmias. Indian Heart J 27, 120 – 126 (1973)" /> <meta name="citation_reference" content="13 Hashimoto K, Haruno A, Matsuzaki T, Sugiyama A and Akiyama K: Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: Which electrophysiological characteristics of drugs are related to their effectiveness? Cardiovasc Drug Ther 5, 805 – 818 (1991)" /> <meta name="citation_reference" content="14 Taira N: Differences in cardiovascular profile among calcium antagonists. Am J Cardiol 59, 24B – 29B (1987)" /> <meta name="citation_reference" content="15 Sun J and Triggle DJ: Calcium channel antagonists: cardiovascular selectivity of action. J Pharmacol Exp Ther 274, 419 – 426 (1995)" /> <meta name="dc.identifier" content="10.1254/jphs.91.163" /> <meta name="journal_code" content="jphs" /> <meta name="journal_title" content="Journal of Pharmacological Sciences" /> <meta name="publisher" content="The Japanese Pharmacological Society" /> <meta name="authors" content="Hideki Dohmoto" /> <meta name="authors_institutions" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="authors" content="Akira Takahara" /> <meta name="authors_institutions" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="authors" content="Hisayuki Uneyama" /> <meta name="authors_institutions" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="authors" content="Ryota Yoshimoto" /> <meta name="authors_institutions" content="Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc." /> <meta name="title" content="Cardiac Ca2+ Channel-Blocking Effects of the Cyproheptadine Derivative AH-1058 in Isolated Guinea Pig Cardiomyocytes" /> <meta name="publication_date" content="2003" /> <meta name="online_date" content="2003/02/20" /> <meta name="volume" content="91" /> <meta name="issue" content="2" /> <meta name="firstpage" content="163" /> <meta name="lastpage" content="166" /> <meta name="doi" content="10.1254/jphs.91.163" /> <meta name="fulltext_world_readable" content="" /> <meta name="pdf_url" content="https://www.jstage.jst.go.jp/article/jphs/91/2/91_2_163/_pdf" /> <meta name="print_issn" content="1347-8613" /> <meta name="online_issn" content="1347-8648" /> <meta name="issn_l" content="1347-8613" /> <meta name="language" content="en" /> <meta name="keywords" content="AH-1058" /> <meta name="keywords" content="cyproheptadine" /> <meta name="keywords" content="L-type Ca2+ current" /> <meta name="abstract" content="The Ca2+ channel-blocking efficacy of the cyproheptadine derivative AH-1058 (4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[(E)-3-(3-methoxy-2-nitro)phenyl-2-propenyl]piperidine hydrochloride) was quantitatively assessed using isolated guinea pig cardiomyocytes. AH-1058 (0.001 – 10 μM) and its mother compound cyproheptadine (1 – 100 μM) reduced the Ca2+ currents elicited from the holding potential of −80 or −40 mV. The IC50 values for cyproheptadine at holding potentials of −80 and −40 mV were 42.44 and 7.75 μM, respectively, whereas those for AH-1058 were 4.91 and 0.32 μM, respectively, whose potency was equivalent to those of the typical Ca2+ channel blocker verapamil. These results suggest that the introduction of the cinnamil structure to cyproheptadine can generate a potent L-type Ca2+ channel-blocking compound as potent as verapamil." /> <meta name="references" content="1 Takahara A, Sugiyama A, Yoshimoto R and Hashimoto K: AH-1058: A novel cardioselective Ca2+ channel blocker. Cardiovasc Drug Rev 19, 279 – 296 (2001)" /> <meta name="references" content="2 Takahara A, Uneyama H, Sasaki N, Ueda H, Dohmoto H, Shoji M, Hara Y, Nakaya H and Yoshimoto R: Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents. J Cardiovasc Pharmacol 33, 625 – 632 (1999)" /> <meta name="references" content="3 Tanaka H, Ichikawa T, Matsui S, Okazaki K, Masumiya H, Kawanishi T and Shigenobu K: Calcium channel antagonistic effects of AH-1058, a novel antiarrhythmic drug, on guinea-pig myocardium. Res Commun Mol Pathol Pharmacol 104, 13 – 21 (1999)" /> <meta name="references" content="4 Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R and Hashimoto K: Antiarrhythmic and cardiohemodynamic effects of a novel Ca2+ channel blocker, AH-1058, assessed in canine arrhythmia models. Eur J Pharmacol 398, 107 – 112 (2000)" /> <meta name="references" content="5 Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R and Hashimoto K: Comparison of cardiovascular effects of a new calcium channel blocker AH-1058 with those of verapamil assessed in blood-perfused canine heart preparations. J Cardiovasc Pharmacol 35, 741 – 748 (2000)" /> <meta name="references" content="6 Takahara A, Sugiyama A, Dohmoto H, Yoshimoto R and Hashimoto K: Electrophysiological and cardiohemodynamic effects of a new type of calcium channel blocker AH-1058 assessed by the canine in vivo model. Jpn J Pharmacol 83, 107 – 112 (2000)" /> <meta name="references" content="7 Takahara A, Dohmoto H, Sugiyama A, Yoshimoto R and Hashimoto K: Cardiovascular action of a cardioselective Ca2+ channel blocker AH-1058 in conscious dogs assessed by telemetry. Eur J Pharmacol 413, 101 – 108 (2001)" /> <meta name="references" content="8 Takahara A, Dohmoto H, Yoshimoto R, Sugiyama A and Hashimoto K: Utilization of telemetry system to assess the cardiovascular profile of AH-1058, a new cardioselective Ca2+ channel blocker, in conscious dogs. Jpn J Pharmacol 85, 331 – 334 (2001)" /> <meta name="references" content="9 Winquist RJ, Siegl PKS, Baskin EP, Bohn DL, Morgan G and Wallace AA: Calcium entry blocker activity of cyproheptadine in isolated cardiovascular preparations. J Pharmacol Exp Ther 230, 103 – 109 (1984)" /> <meta name="references" content="10 Uneyama H, Uchida H, Konda T, Yoshimoto R and Akaike N: Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels. Eur J Pharmacol 373, 93 – 100 (1999)" /> <meta name="references" content="11 Uneyama H, Uchida H, Maeda K, Yoshimoto R, Watanabe Y and Inoue K: Non-L-type actions of organic Ca2+ channel blockers: implications for Na+ and N-type Ca2+ channel blockades. In Calcium Ion Modulators: The New Wave of Psychotropic Drugs, Edited by Inoue K and Watanabe Y, pp 13 – 23, Harwood Academic Publishers, The Netherlands (1998)" /> <meta name="references" content="12 Singh PK, Pendse VK and Bhandari DS: Cyproheptadine in ventricular arrhythmias. Indian Heart J 27, 120 – 126 (1973)" /> <meta name="references" content="13 Hashimoto K, Haruno A, Matsuzaki T, Sugiyama A and Akiyama K: Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: Which electrophysiological characteristics of drugs are related to their effectiveness? Cardiovasc Drug Ther 5, 805 – 818 (1991)" /> <meta name="references" content="14 Taira N: Differences in cardiovascular profile among calcium antagonists. Am J Cardiol 59, 24B – 29B (1987)" /> <meta name="references" content="15 Sun J and Triggle DJ: Calcium channel antagonists: cardiovascular selectivity of action. 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position:relative;"> <div class="journal-name">Journal of Pharmacological Sciences</div> <div id="journal-right-infosection" class="col-sm-6" style="padding-top:15px;"> <div class="fs-12"> Online ISSN : 1347-8648<br> Print ISSN : 1347-8613<br> ISSN-L : 1347-8613 </div> </div> <div class="journal-tags-clearfix"></div> </div> <div class="clearfix"></div> </div> </div> </div>   <div class="colorscheme09-normal"> <div class="container"> <div id="second-level-nav-tabs"> <ul class="nav nav-tabs"> <li ><a href="https://www.jstage.jst.go.jp/browse/jphs/-char/en">Journal home</a></li> <li ><a href="https://www.jstage.jst.go.jp/browse/jphs/list/-char/en">All issues</a></li> <li ><a href="https://www.jstage.jst.go.jp/browse/jphs/_pubinfo/-char/en">About the journal</a></li> </ul> </div> </div> </div> <div class="container"> <div class="row"> <div class="col-md-24">  <ul class="global-breadcrumbs"> <li><a href="https://www.jstage.jst.go.jp/browse/-char/en">J-STAGE home</a></li> <li>/</li> <li><a href="https://www.jstage.jst.go.jp/browse/jphs/-char/en" class="customTooltip" title="Journal of Pharmacological Sciences">Journal of Pharmacological Sci ...</a></li> <li> / </li> <li><a href='https://www.jstage.jst.go.jp/browse/jphs/91/2/_contents/-char/en'>Volume 91 (2003) Issue 2</a></li><li> / </li><li>Article overview</li> </ul> <div class="clearfix"></div>  </div> </div> <div class="row">  <div class="col-md-18">  <div class="top-margin-2x bottom-margin-2x"></div> <div class="global-article-subtitle">Short Communications</div> <div class="global-article-title">Cardiac Ca<sup>2+</sup> Channel-Blocking Effects of the Cyproheptadine Derivative AH-1058 in Isolated Guinea Pig Cardiomyocytes</div> <div class="global-article-inner-title"></div> <div class="global-authors-name-tags"> <a name = "authorNmlist" id="authorNmList"></a><a href="https://www.jstage.jst.go.jp/search/global/_search/-char/en?item=8&word=Hideki+Dohmoto" class="customTooltip" title="Hideki Dohmoto, Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc."><span>Hideki Dohmoto</span></a>, <a href="https://www.jstage.jst.go.jp/search/global/_search/-char/en?item=8&word=Akira+Takahara" class="customTooltip" title="Akira Takahara, Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc."><span>Akira Takahara</span></a>, <a href="https://www.jstage.jst.go.jp/search/global/_search/-char/en?item=8&word=Hisayuki+Uneyama" class="customTooltip" title="Hisayuki Uneyama, Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc."><span>Hisayuki Uneyama</span></a>, <a href="https://www.jstage.jst.go.jp/search/global/_search/-char/en?item=8&word=Ryota+Yoshimoto" class="customTooltip" title="Ryota Yoshimoto, Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc."><span>Ryota Yoshimoto</span></a> <div class="accordion_container"> <div class="accordion_head plus-icn"name="authInfo" id="authInfo">Author information</div> <div class="accordion_body new_accordion_body_style" style="display: none;"> <ul class="accodion_body_ul"> <li> <span style="font-size:1.1em">Hideki Dohmoto</span> <p class="accordion_affilinfo"> Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc. </p> </li> <li> <span style="font-size:1.1em">Akira Takahara</span> <p class="accordion_affilinfo"> Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc. </p> </li> <li> <span style="font-size:1.1em">Hisayuki Uneyama</span> <p class="accordion_affilinfo"> Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc. </p> </li> <li> <span style="font-size:1.1em">Ryota Yoshimoto</span> <p class="accordion_affilinfo"> Pharmaceutical Research Laboratories, Pharmaceuticals Company, Ajinomoto Co., Inc. </p> </li> </ul> </div> </div> <div class="corr-auth-sapopup-wrap" id="saPopup" style="display:none"> <div class="corr-auth-sapopup-overlay" id="saWindow"></div> <div class="corr-auth-sapopup-inner"> <div class="corr-auth-sapopup-cont"> <div class="sapopup-title"><h4>Corresponding author</h4></div> <div class="subject-list subject-sapopup-list" > <div class="corr-auth-subject-li"> <div class="corr-auth-subject-item" id="corrAuthMailContainer" style="display:none"> <span class="fa fa-envelope outlook-share-icn"></span> <a id="corrAuthMail" class="bluelink-style"></a> </div> </div> </div> <div class="subject-list subject-sapopup-list" > <div class="corr-auth-subject-li"> <div class="corr-auth-subject-item" id="corrAuthOrcidContainer" style="display:none"> <img src="/web/images/id-logo.jpg" class="id-logo" alt="ORCID" /> <a target="_blank" rel="noopener noreferrer" id="corrAuthOrcid" class="bluelink-style"></a> </div> </div> </div> </div> </div> </div> </div> <div class="global-para"> Keywords: <a href="/search/global/_search/-char/en?item=5&word=AH-1058" class="bluelink-style">AH-1058</a>, <a href="/search/global/_search/-char/en?item=5&word=cyproheptadine" class="bluelink-style">cyproheptadine</a>, <a href="/search/global/_search/-char/en?item=5&word=L-type+Ca2%2B+current" class="bluelink-style">L-type Ca<sup>2+</sup> current</a> </div> <div class="global-tags"><span class="tags-wrap original-tag-style" title="JOURNAL">JOURNAL</span> <span class="tags-wrap freeaccess-tag-style" title="FREE ACCESS">FREE ACCESS</span> <br> </div> <p class="global-para"> 2003 Volume 91 Issue 2 Pages 163-166 </p> <div class="articleoverview-doi-wrap" id="fig-doi"> <span class="doi-icn">DOI</span> <a href="https://doi.org/10.1254/jphs.91.163" class="bluelink-style" style="word-break:break-all">https://doi.org/10.1254/jphs.91.163</a> </div> <div class="articleoverview-doi-wrap"></div> <div class="top-margin-2x bottom-margin-2x"></div> <div class="accordion_container"> <div class="accordion_head plus-icn">Details</div> <div class="accordion_body new_accordion_body_style" style="display: none;"> <ul class="accodion_body_ul accodion_detail"> <li> <span class="accodion_lic">Published: 2003 </span> <span class="accodion_lic">Received: -</span> <span class="accodion_lic">Available on J-STAGE: February 20, 2003</span> <span class="accodion_lic">Accepted: -</span> <span class="accodion_lic"> Advance online publication: - </span> <span class="accodion_lic">Revised: -</span> </li> </ul> </div> </div> </div>   <div class="col-md-6 print-non-disp"> <div id="third-level-navigation"> <a href="https://www.jstage.jst.go.jp/article/jphs/91/2/91_2_163/_pdf/-char/en" class="thirdlevel-pdf-btn"> Download PDF <span class="download-file-size">(167K)</span> </a> <span class="third-level-nav-divider"></span> <div class="third-level-sublinks"> <span class="heading">Download citation</span> <span class="fa fa-file-o"></span><a href="https://www.jstage.jst.go.jp/AF06S010ShoshJkuDld?sryCd=jphs&noVol=91&noIssue=2&kijiCd=91_2_163&kijiLangKrke=en&kijiToolIdHkwtsh=AT0072&request_locale=EN">RIS</a> <p 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class="section-title-noborder-14">Share</div> <ul class="global-share-x-icons-list"> <li><a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fdoi.org%2F10.1254%2Fjphs.91.163" target="_blank" rel="noopener noreferrer"><span class="fa fa-facebook facebook-share-icn"></span></a></li> <li><a href="http://twitter.com/share?url=https%3A%2F%2Fdoi.org%2F10.1254%2Fjphs.91.163&text=J-STAGE+Articles+-+Cardiac+Ca%3Csup%3E2%2B%3C%2Fsup%3E+Channel-Blocking+Effects+of+the+Cyproheptadine+Derivative+AH-1058+in+Isolated+Guinea+Pig+Cardiomyocytes" target="_blank" rel="noopener noreferrer"><span class="twitter-share-icn" style="background:#000000;display:inline-block;font-size:20px;"><img src="/web/images/logo-white.png" width="16" height="16" alt="X"></img></span></a></li> <li><a href="mailto:?body=Journal%20of%20Pharmacological%20Sciences%0A%0ACardiac%20Ca%3Csup%3E2%2B%3C%2Fsup%3E%20Channel-Blocking%20Effects%20of%20the%20Cyproheptadine%20Derivative%20AH-1058%20in%20Isolated%20Guinea%20Pig%20Cardiomyocytes%0A%0Ahttps%3A%2F%2Fdoi.org%2F10.1254%2Fjphs.91.163%0A"> <span class="fa fa-envelope outlook-share-icn"></span></a></li> <li><a href="http://www.mendeley.com/import/?doi=10.1254/jphs.91.163" target="_blank" rel="noopener noreferrer"><span class="mendeley-share-icn"><img src="/web/images/mendeley-share-icon.png" width="32" height="32" alt=""/> </span></a></li> </ul> </div>  </div>   <div class="non-sticky-content"> <div id="non-sticky-content-leftsection"> <div id="article-overiew-abstract-wrap">  <div class="section-title-18">Abstract</div> <p class="global-para-14"> The Ca<sup>2+</sup> channel-blocking efficacy of the cyproheptadine derivative AH-1058 (4-(5<i>H</i>-dibenzo[<i>a,d</i>]cyclohepten-5-ylidene)-1-[(<i>E</i>)-3-(3-methoxy-2-nitro)phenyl-2-propenyl]piperidine hydrochloride) was quantitatively assessed using isolated guinea pig cardiomyocytes. AH-1058 (0.001 – 10 μM) and its mother compound cyproheptadine (1 – 100 μM) reduced the Ca<sup>2+</sup> currents elicited from the holding potential of −80 or −40 mV. The IC<sub>50</sub> values for cyproheptadine at holding potentials of −80 and −40 mV were 42.44 and 7.75 μM, respectively, whereas those for AH-1058 were 4.91 and 0.32 μM, respectively, whose potency was equivalent to those of the typical Ca<sup>2+</sup> channel blocker verapamil. These results suggest that the introduction of the cinnamil structure to cyproheptadine can generate a potent L-type Ca<sup>2+</sup> channel-blocking compound as potent as verapamil.<br> </p> <div style="text-align:center;"> </div> </div>   <div id="datarepo-wrap"></div> <input type="hidden" id="figshareArticleSearchUrl" value="https://api.figshare.com/v2/articles">   <div id="article-overiew-references-wrap"> <div class="section-title-18" style="display:none;">References (15)</div> </div>   <div id="article-overiew-related-wrap"> <div class="section-title-18" style="display:none;">Related articles (0)</div> </div>   <div id="figures-tables-wrap"> <div class="section-title-noborder-18" style="display:none;">Figures (0)</div> </div>   <div id="author-information-wrap" style=""> <div id="author_info_main"> <div id="author_info_title" class="section-title-18" onClick="getAuthorList(this)"> <img src="/web/images/data-services/J-GLOBAL.jpg" alt="" class="jglobal_img"> <span 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