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Fawwaz‬‏</title> <meta name="description" content="Search results for: Bahaa Fawwaz‬‏"> <meta name="keywords" content="Bahaa Fawwaz‬‏"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Bahaa Fawwaz‬‏"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 9</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Bahaa Fawwaz‬‏</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> A Comparative Study of Essential Oils Used in Papyrus Sterilization: A Case Study from the Early Islamic Period</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bahaa%20Fawwaz%E2%80%AC%E2%80%8F">Bahaa Fawwaz‬‏</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study was conducted on a papyrus housed at the Museum of Islamic Art in Cairo, Egypt. This papyrus was inscribed with black ink. Twelve fungal species were isolated and identified. Five types of fungi were ultimately identified to complete the study. The isolated fungi were then incubated for three months after the aging procedure. This study investigates the in-vitro growth inhibition of Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum, Trichoderma longibrachiatum Rifai, and Paecilomyces variotii on papyrus. The hyphal growth was observed using the environmental scanning electron microscope (ESEM). Natural oils, such as lavender oil, lemongrass oil, and rosemary oil, were used. The impact of these natural oils on the newly aged papyrus was assessed using scanning electron microscopy and color analysis to identify the most effective oils for inhibiting fungus growth. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=conservation" title="conservation">conservation</a>, <a href="https://publications.waset.org/abstracts/search?q=papyrus" title=" papyrus"> papyrus</a>, <a href="https://publications.waset.org/abstracts/search?q=fungi" title=" fungi"> fungi</a>, <a href="https://publications.waset.org/abstracts/search?q=growth" title=" growth"> growth</a>, <a href="https://publications.waset.org/abstracts/search?q=environmental" title=" environmental"> environmental</a>, <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title=" essential oils"> essential oils</a> </p> <a href="https://publications.waset.org/abstracts/186141/a-comparative-study-of-essential-oils-used-in-papyrus-sterilization-a-case-study-from-the-early-islamic-period" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186141.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">47</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Biobutanol Production from Date Palm Waste by Clostridium acetobutylicum</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Diya%20Alsafadi">Diya Alsafadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Fawwaz%20Khalili"> Fawwaz Khalili</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20W.%20Amer"> Mohammad W. Amer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Butanol is an important industrial solvent and potentially a better liquid transportation biofuel than ethanol. The cost of feedstock is one key problem associated with the biobutanol production. Date palm is sugar-rich fruit and highly abundant. Thousands of tons of date wastes that generated from date processing industries are thrown away each year and imposing serious environmental problems. To exploit the utilization of renewable biomass feedstock, date palm waste was utilized for butanol production by Clostridium acetobutylicum DSM 1731. Fermentation conditions were optimized by investigating several parameters that affect the production of butanol such as temperature, substrate concentration and pH. The highest butanol yield (1.0 g/L) and acetone, butanol, and ethanol (ABE) content (1.3 g/L) were achieved at 20 g/L date waste, pH 5.0 and 37 °C. These results suggest that date palm waste can be used for biobutanol production. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biofuel" title="biofuel">biofuel</a>, <a href="https://publications.waset.org/abstracts/search?q=acetone-butanol-ethanol%20fermentation" title=" acetone-butanol-ethanol fermentation"> acetone-butanol-ethanol fermentation</a>, <a href="https://publications.waset.org/abstracts/search?q=date%20palm%20waste" title=" date palm waste"> date palm waste</a>, <a href="https://publications.waset.org/abstracts/search?q=Clostridium%20acetobutylicum" title=" Clostridium acetobutylicum"> Clostridium acetobutylicum</a> </p> <a href="https://publications.waset.org/abstracts/55719/biobutanol-production-from-date-palm-waste-by-clostridium-acetobutylicum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">353</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Towards a Complete Automation Feature Recognition System for Sheet Metal Manufacturing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bahaa%20Eltahawy">Bahaa Eltahawy</a>, <a href="https://publications.waset.org/abstracts/search?q=Mikko%20Ylih%C3%A4rsil%C3%A4"> Mikko Ylihärsilä</a>, <a href="https://publications.waset.org/abstracts/search?q=Reino%20Virrankoski"> Reino Virrankoski</a>, <a href="https://publications.waset.org/abstracts/search?q=Esko%20Pet%C3%A4j%C3%A4"> Esko Petäjä</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sheet metal processing is automated, but the step from product models to the production machine control still requires human intervention. This may cause time consuming bottlenecks in the production process and increase the risk of human errors. In this paper we present a system, which automatically recognizes features from the CAD-model of the sheet metal product. By using these features, the system produces a complete model of the particular sheet metal product. Then the model is used as an input for the sheet metal processing machine. Currently the system is implemented, capable to recognize more than 11 of the most common sheet metal structural features, and the procedure is fully automated. This provides remarkable savings in the production time, and protects against the human errors. This paper presents the developed system architecture, applied algorithms and system software implementation and testing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=feature%20recognition" title="feature recognition">feature recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=automation" title=" automation"> automation</a>, <a href="https://publications.waset.org/abstracts/search?q=sheet%20metal%20manufacturing" title=" sheet metal manufacturing"> sheet metal manufacturing</a>, <a href="https://publications.waset.org/abstracts/search?q=CAD" title=" CAD"> CAD</a>, <a href="https://publications.waset.org/abstracts/search?q=CAM" title=" CAM"> CAM</a> </p> <a href="https://publications.waset.org/abstracts/67850/towards-a-complete-automation-feature-recognition-system-for-sheet-metal-manufacturing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67850.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">355</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> 2D Numerical Modeling for Induced Current Distribution in Soil under Lightning Impulse Discharge</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fawwaz%20Eniola%20Fajingbesi">Fawwaz Eniola Fajingbesi</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Shahida%20Midia"> Nur Shahida Midia</a>, <a href="https://publications.waset.org/abstracts/search?q=Elsheikh%20M.%20A.%20Elsheikh"> Elsheikh M. A. Elsheikh</a>, <a href="https://publications.waset.org/abstracts/search?q=Siti%20Hajar%20Yusoff"> Siti Hajar Yusoff</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Empirical analysis of lightning related phenomena in real time is extremely dangerous due to the relatively high electric discharge involved. Hence, design and optimization of efficient grounding systems depending on real time empirical methods are impeded. Using numerical methods, the dynamics of complex systems could be modeled hence solved as sets of linear and non-linear systems . In this work, the induced current distribution as lightning strike traverses the soil have been numerically modeled in a 2D axial-symmetry and solved using finite element method (FEM) in COMSOL Multiphysics 5.2 AC/DC module. Stratified and non- stratified electrode system were considered in the solved model and soil conductivity (σ) varied between 10 – 58 mS/m. The result discussed therein were the electric field distribution, current distribution and soil ionization phenomena. It can be concluded that the electric field and current distribution is influenced by the injected electric potential and the non-linearity in soil conductivity. The result from numerical calculation also agrees with previously laboratory scale empirical results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=current%20distribution" title="current distribution">current distribution</a>, <a href="https://publications.waset.org/abstracts/search?q=grounding%20systems" title=" grounding systems"> grounding systems</a>, <a href="https://publications.waset.org/abstracts/search?q=lightning%20discharge" title=" lightning discharge"> lightning discharge</a>, <a href="https://publications.waset.org/abstracts/search?q=numerical%20model" title=" numerical model"> numerical model</a>, <a href="https://publications.waset.org/abstracts/search?q=soil%20conductivity" title=" soil conductivity"> soil conductivity</a>, <a href="https://publications.waset.org/abstracts/search?q=soil%20ionization" title=" soil ionization"> soil ionization</a> </p> <a href="https://publications.waset.org/abstracts/89250/2d-numerical-modeling-for-induced-current-distribution-in-soil-under-lightning-impulse-discharge" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89250.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Biological Feedstocks for Sustainable Aviation Fuel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Odi%20Fawwaz%20Alrebei">Odi Fawwaz Alrebei</a>, <a href="https://publications.waset.org/abstracts/search?q=Rim%20Ismail"> Rim Ismail</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustainable aviation fuel (SAF) has emerged as a critical solution for reducing the aviation sector's carbon footprint. Biological feedstocks, such as lignocellulosic biomass, microalgae, used cooking oil, and municipal solid waste, offer significant potential to replace fossil-based jet fuels with renewable alternatives. This review paper aims to critically examine the current landscape of biological feedstocks for SAF production, focusing on feedstock availability, conversion technologies, and environmental impacts. The paper evaluates the biochemical pathways employed in transforming these feedstocks into SAF, such as hydrothermal liquefaction, Fischer-Tropsch synthesis, and microbial fermentation, highlighting the advancements and challenges in each method. Additionally, the sustainability of biological feedstocks is analyzed with respect to lifecycle emissions, land use, and water consumption, emphasizing the need for region-specific strategies to maximize benefits. Special attention is given to the role of microbial consortia in optimizing feedstock degradation and conversion processes. The review concludes by discussing the scalability and economic viability of biological feedstock-based SAF, with a focus on policy frameworks and technological innovations that can facilitate widespread adoption. This comprehensive review underscores the pivotal role of biological feedstocks in achieving a decarbonized aviation sector and identifies future research directions for improving SAF production efficiency and sustainability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fuel%20diversity" title="fuel diversity">fuel diversity</a>, <a href="https://publications.waset.org/abstracts/search?q=biological%20feedstocks" title=" biological feedstocks"> biological feedstocks</a>, <a href="https://publications.waset.org/abstracts/search?q=SAF" title=" SAF"> SAF</a>, <a href="https://publications.waset.org/abstracts/search?q=aviation" title=" aviation"> aviation</a> </p> <a href="https://publications.waset.org/abstracts/192674/biological-feedstocks-for-sustainable-aviation-fuel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192674.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">14</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Novel Nanomagnetic Beads Based- Latex Agglutination Assay for Rapid Diagnosis of Human Schistosomiasis Haematobium</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20Aly">Ibrahim Aly</a>, <a href="https://publications.waset.org/abstracts/search?q=Rabab%20Zalat"> Rabab Zalat</a>, <a href="https://publications.waset.org/abstracts/search?q=Bahaa%20EL%20Deen%20W.%20El%20Aswad"> Bahaa EL Deen W. El Aswad</a>, <a href="https://publications.waset.org/abstracts/search?q=Ismail%20M.%20Moharm"> Ismail M. Moharm</a>, <a href="https://publications.waset.org/abstracts/search?q=Basam%20M.%20Masoud"> Basam M. Masoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20Diab"> Tarek Diab</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of the present study was to evaluate the novel nanomagnetic beads based–latex agglutination assay (NMB-LAT) as a simple test for diagnosis of S. haematobium as well as standardize the novel nanomagnetic beads based –ELISA (NMB-ELISA). According to urine examination this study included 85 S. haematobium infected patients, 30 other parasites infected patients and 25 negative control samples. The sensitivity of novel NMB-LAT was 82.4% versus 96.5% and 88.2% for NMB-ELISA and currently used sandwich ELISA respectively. The specificity of NMB-LAT was 83.6% versus 96.3% and 87.3% for NMB-ELISA and currently used sandwich ELISA respectively. In conclusion, the novel NMB-ELISA is a valuable applicable diagnostic technique for diagnosis of human schistosomiasis haematobium. The novel NMB-ELISA assay is a suitable applicable diagnostic method in field survey especially when followed by ELISA as a confirmatory test in query false negative results. Trials are required to increase the sensitivity and specificity of NMB-ELISA assay. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title="diagnosis">diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=iatex%20agglutination" title=" iatex agglutination"> iatex agglutination</a>, <a href="https://publications.waset.org/abstracts/search?q=nanomagnetic%20beads" title=" nanomagnetic beads"> nanomagnetic beads</a>, <a href="https://publications.waset.org/abstracts/search?q=sandwich%20ELISA" title=" sandwich ELISA"> sandwich ELISA</a> </p> <a href="https://publications.waset.org/abstracts/2898/novel-nanomagnetic-beads-based-latex-agglutination-assay-for-rapid-diagnosis-of-human-schistosomiasis-haematobium" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2898.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">382</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Organism Profile Causing Prosthetic Joint Infection Continues to Evolve</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bahaa%20Eldin%20Kornah">Bahaa Eldin Kornah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The organism profile for peri-prosthetic joint infection caused by hematogenous seeding or direct inoculations is changing. The organisms that cause prosthetic joint infections range from normal skin colonizers to highly virulent pathogens. The pathogens continue to evolve. While Staphylococcus aureus continues to be the leading organism, gram-negative bacilli account for approximately 7% of cases and that incidence is increasing. Methicillin-resistant S. aureus(MRSA) accounts for approximately 10% of all infections occurring in the community setting and 20% of those in the health care setting. The list of organisms causing PJI has expanded in recent years. It is important to have an understanding of which organisms may be causing a periprosthetic joint infection based on where the patient contracted it and their recent medical history. Also, recent technology has expanded rapidly and new methods to detect the pathogen and why we failed in detecting it. There are a number of explanations for the latter finding, perhaps the most important reason being the liberal use of antibiotics that interferes with the isolation of the infective organism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=infection" title="infection">infection</a>, <a href="https://publications.waset.org/abstracts/search?q=periprosthetic" title=" periprosthetic"> periprosthetic</a>, <a href="https://publications.waset.org/abstracts/search?q=hip" title=" hip"> hip</a>, <a href="https://publications.waset.org/abstracts/search?q=organism%20profile" title=" organism profile"> organism profile</a>, <a href="https://publications.waset.org/abstracts/search?q=joint%20infection" title=" joint infection"> joint infection</a>, <a href="https://publications.waset.org/abstracts/search?q=joint%20infection" title=" joint infection"> joint infection</a> </p> <a href="https://publications.waset.org/abstracts/159166/organism-profile-causing-prosthetic-joint-infection-continues-to-evolve" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159166.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Effect of Unilateral Unoperated Ovarian Endometrioma on Responsiveness to Hyperstimulation </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdelmaguid%20Ramzy">Abdelmaguid Ramzy</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Bahaa"> Mohamed Bahaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The effects of ovarian endometrioma on fertility outcomes with IVF have been always related to poor outcomes. Objective: To evaluate the effect of unilateral unoperated ovarian endometrioma < 2cm on the number of developing follicles and compare them with the contralateral ovary as a control. Design: Retrospective case control study. Setting: KasrEl-Aini IVF center. Patient(s): We studied 32 women with unilateral endometrioma who underwent their first IVF cycle. Methods: 32 Patients aged between 20-35 years selected for IVF who were diagnosed with one unilateral endometrioma (diameter <2 cm) and who did not undergo previous ovarian surgery were retrospectively identified. The number of follicles > 17 mm during folliculometry on the day of HCG trigger in the ovary that contained endometrioma were compared with those from the contralateral ovary. They were all hyperstimulated using long protocol with (225-300 IU) gonadotrophins. Primary outcome: The number of follicles > 17 mm during folliculometry on the day of HCG trigger. Result(s): The mean ± SD age, Day 3 serum FSH and LH were 27± 3.7 years, 5.8 ± 1.6 IU/ml and 4.5 ± 1.7 IU/ml respectively. There was no significant difference in the number of follicles > 17 mm on the day of HCG trigger in the ovary that contained endometrioma (4.4 ±2.5) and in the opposite ovary (4.5 ± 2.8) (P= 0.48). Conclusion: The presence of ovarian endometrioma in a controlled ovarian hyperstimulation cycle for IVF treatment is not associated with a reduced number of follicles > 17 mm during folliculometry on the day of HCG trigger. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometrioma" title="endometrioma">endometrioma</a>, <a href="https://publications.waset.org/abstracts/search?q=folliculometry" title=" folliculometry"> folliculometry</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperstimulation" title=" hyperstimulation"> hyperstimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=fertility" title=" fertility"> fertility</a> </p> <a href="https://publications.waset.org/abstracts/8259/effect-of-unilateral-unoperated-ovarian-endometrioma-on-responsiveness-to-hyperstimulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">209</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Epoxomicin Affects Proliferating Neural Progenitor Cells of Rat</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bahaa%20Eldin%20A.%20Fouda">Bahaa Eldin A. Fouda</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaled%20N.%20Yossef"> Khaled N. Yossef</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Elhosseny"> Mohamed Elhosseny</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Lotfy"> Ahmed Lotfy</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Salama"> Mohamed Salama</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Sobh"> Mohamed Sobh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Developmental neurotoxicity (DNT) entails the toxic effects imparted by various chemicals on the brain during the early childhood period. As human brains are vulnerable during this period, various chemicals would have their maximum effects on brains during early childhood. Some toxicants have been confirmed to induce developmental toxic effects on CNS e.g. lead, however; most of the agents cannot be identified with certainty due the defective nature of predictive toxicology models used. A novel alternative method that can overcome most of the limitations of conventional techniques is the use of 3D neurospheres system. This in-vitro system can recapitulate most of the changes during the period of brain development making it an ideal model for predicting neurotoxic effects. In the present study, we verified the possible DNT of epoxomicin which is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. Rat neural progenitor cells were isolated from rat embryos (E14) extracted from placental tissue. The cortices were aseptically dissected out from the brains of the fetuses and the tissues were triturated by repeated passage through a fire-polished constricted Pasteur pipette. The dispersed tissues were allowed to settle for 3 min. The supernatant was, then, transferred to a fresh tube and centrifuged at 1,000 g for 5 min. The pellet was placed in Hank’s balanced salt solution cultured as free-floating neurospheres in proliferation medium. Two doses of epoxomicin (1µM and 10µM) were used in cultured neuropsheres for a period of 14 days. For proliferation analysis, spheres were cultured in proliferation medium. After 0, 4, 5, 11, and 14 days, sphere size was determined by software analyses. The diameter of each neurosphere was measured and exported to excel file further to statistical analysis. For viability analysis, trypsin-EDTA solution were added to neurospheres for 3 min to dissociate them into single cells suspension, then viability evaluated by the Trypan Blue exclusion test. Epoxomicin was found to affect proliferation and viability of neuropsheres, these effects were positively correlated to doses and progress of time. This study confirms the DNT effects of epoxomicin on 3D neurospheres model. The effects on proliferation suggest possible gross morphologic changes while the decrease in viability propose possible focal lesion on exposure to epoxomicin during early childhood. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neural%20progentor%20cells" title="neural progentor cells">neural progentor cells</a>, <a href="https://publications.waset.org/abstracts/search?q=epoxomicin" title=" epoxomicin"> epoxomicin</a>, <a href="https://publications.waset.org/abstracts/search?q=neurosphere" title=" neurosphere"> neurosphere</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20and%20health%20sciences" title=" medical and health sciences"> medical and health sciences</a> </p> <a href="https://publications.waset.org/abstracts/15247/epoxomicin-affects-proliferating-neural-progenitor-cells-of-rat" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15247.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">426</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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