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et_pb_fullwidth_header et_pb_fullwidth_header_0 et_pb_text_align_center et_pb_bg_layout_dark et_pb_fullscreen"><div class="et_pb_fullwidth_header_container center"><div class="header-content-container center"><div class="header-content"><h1 class="et_pb_module_header">Bioinformatique: l'alliance de la biologie et des math茅matiques.</h1><div class="et_pb_header_content_wrapper"><p style="text-align: center;">Minimiser les risques de faisabilit茅 de projets biotechnologiques, rationaliser et acc茅l茅rer les d茅veloppements de nouveaux proc茅d茅s de bioproduction.</p></div> <a class="et_pb_button et_pb_more_button et_pb_button_one" href="#bioinformatique">D茅couvrir</a></div></div></div><div class="et_pb_fullwidth_header_overlay"></div><div class="et_pb_fullwidth_header_scroll"></div></section></div><div id="bioinformatique" class="et_pb_section et_pb_section_1 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_0"><div class="et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_dark"><div class="et_pb_text_inner"><p>L’industrie de la chimie est 脿 un tournant de son histoire. La demande en produit de plus grande naturalit茅 et dont les modes de productions offrent une empreinte environnementale bien moindre. Les professionnels du secteur doivent s’adapter 脿 ces nouvelles demandes, tout en assurant la soutenabilit茅 de leur approvisionnement et de leur production. Nombre d’entre eux se tournent ainsi vers des m茅thodes et des applications biotechnologiques 茅coresponsables pour remplacer les anciens proc茅d茅s tr猫s gourmands en ressources et 茅nergies fossiles.</p><p>Mais dans le domaine des biotechnologies, transformer une mati猫re premi猫re en une mol茅cule d’int茅r锚t ne s’improvise pas. <br />Pour y parvenir, il faut en amont :</p><ul><li>Trouver le bon substrat 脿 utiliser.</li><li>S茅lectionner les meilleurs micro-organismes susceptibles de produire le compos茅 voulu.</li><li>Leur apprendre les r茅actions chimiques les plus appropri茅es.</li><li>Rendre ces r茅actions les plus efficientes et propres possibles.</li><li>Identifier les enzymes qui viendront aider les levures et les bact茅ries dans leur travail de transformation.</li></ul><p>Gr芒ce 脿 son savoir-faire en bioinformatique, BGene ma卯trise toutes ces 茅tapes.</p></div></div></div></div></div><div class="et_pb_section et_pb_section_2 et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_1"><div class="et_pb_column et_pb_column_1_3 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_0"> <span class="et_pb_image_wrap "><img fetchpriority="high" decoding="async" width="1636" height="1769" src="https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique-sans-fond.png" alt="BGene poss猫de un p么le de d茅veloppement bioinformatique." title="__Bioinformatique-sans fond" srcset="https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique-sans-fond.png 1636w, https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique-sans-fond-1280x1384.png 1280w, https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique-sans-fond-980x1060.png 980w, https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique-sans-fond-480x519.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1636px, 100vw" class="wp-image-1512" /></span></div></div><div class="et_pb_with_border et_pb_column_2_3 et_pb_column et_pb_column_2 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h2><span style="font-family: 'Esphimere Semi Bold',sans-serif;">La puissance de la bioinformatique.</span></h2></div></div><div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>La bioinformatique (ou bio-informatique) fait le lien entre la biologie, les math茅matiques, l’informatique et les statistiques. Elle permet de relier entre elles les capacit茅s de mod茅lisation et d’analyse d’ordinateurs toujours plus performants avec la masse d’informations en constante 茅volution dans les domaines des sciences de la vie.</p><p>脌 l’aide de logiciels et de programmes sp茅cialis茅s, les experts s’efforcent de r茅soudre des probl猫mes li茅s 脿 la g茅nomique et explorent, cartographient, s茅lectionnent et optimisent les micro-organismes vivants.</p><p>Dans nos laboratoires, la bioinformatique pr茅pare le terrain aux applications biotechnologiques. Nos biologistes et bioinformaticiens l’utilisent pour tester, 茅liminer et valider des hypoth猫ses de travail qui seront ensuite mises en application dans notre WetLab. Nos outils innovants de calcul in silico nous permettent de gagner du temps en isolant les micro-orgnismes et les enzymes les plus int茅ressants pour nos clients. Ils nous permettent 茅galement de minimiser les co没ts de production en r茅duisant au strict n茅cessaire le nombre de tests en WetLab ainsi que le risque d’茅chec dans la phase de d茅veloppement.</p></div></div></div></div><div class="et_pb_row et_pb_row_2 reverse"><div class="et_pb_with_border et_pb_column_2_3 et_pb_column et_pb_column_3 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h2><span style="font-family: 'Esphimere Semi Bold',sans-serif;">Le savoir-faire bioinformatique de BGene: des solutions sur mesure adaptables 脿 tous les besoins de nos clients.</span></h2></div></div><div class="et_pb_module et_pb_text et_pb_text_4 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Le p么le bioinformatique de BGene comprend 4 modules distincts mais compl茅mentaires, chacun d’entre eux servant un but bien pr茅cis.</p></div></div><div class="et_pb_module et_pb_toggle et_pb_toggle_0 et_pb_toggle_item et_pb_toggle_close"><h3 class="et_pb_toggle_title">Pathway Finder</h3><div class="et_pb_toggle_content clearfix"><p>Notre module de r茅trobiosynth猫se. Il nous permet de trouver les r茅actions biochimiques essentielles 脿 la transformation d鈥檜n substrat en une mol茅cule d鈥檌nt茅r锚t et s茅lectionne les s茅quences g茅n茅tiques cl茅s qui encodent ces r茅actions. L鈥檕util permet aussi d鈥檌ntuiter des r茅actions biochimiques non d茅crites mais proches structurellement des r茅actions connues.</p><p>Le r茅sultat de ce module est une liste de voies m茅taboliques, class茅es par ordre de faisabilit茅.</p></div></div><div class="et_pb_module et_pb_toggle et_pb_toggle_1 et_pb_toggle_item et_pb_toggle_close"><h3 class="et_pb_toggle_title">Host Finder</h3><div class="et_pb_toggle_content clearfix"><p>Une fois les r茅actions biochimiques n茅cessaires identifi茅es par Pathway Finder, Host Finder va trouver l’h么te qui r茅agira le mieux 脿 la mise en 艙uvre de ces r茅actions trouve l鈥檋么te. Une souche microbienne 芦 pr茅cabl茅e 禄 en quelque sorte, munie de g猫nes r茅ceptifs qui seront activ茅s par des prot茅ines sp茅cifiques. D鈥檃utres crit猫res, m锚lant expertise microbiologique, et analyse r茅glementaire interviennent dans la s茅lection d鈥檋么te d鈥檌nt茅r锚t.</p><p>Host Finder 茅tablit une liste de 3 脿 10 h么tes potentiels, et expose les pour et contres de chacun.</p><p>La d茅cision finale sur le choix de l鈥檋么te revient au client, apr猫s discussion avec BGene.</p></div></div><div class="et_pb_module et_pb_toggle et_pb_toggle_2 et_pb_toggle_item et_pb_toggle_close"><h3 class="et_pb_toggle_title">Dezyme</h3><div class="et_pb_toggle_content clearfix"><p>Dezyme va trouver la ou les enzymes les plus efficaces afin de d茅clencher les r茅actions m茅taboliques identifi茅es par Pathway Finder. Ces prot茅ines peuvent 锚tre d茅j脿 pr茅sentes dans la nature, ou avoir 茅t茅 con莽ues par d’autres laboratoires tout en restant libres de droits. Dezyme les identifiera tr猫s rapidement et dispose de plusieurs leviers pour s鈥檃ffranchir d鈥檜ne 茅ventuelle non libert茅 d鈥檈xploitation</p><p>Mais il arrive fr茅quemment que l鈥檃ctivit茅 biologique d’une enzyme soient proches – mais pas suffisamment – de celle escompt茅e. Alors Dezyme va au-del脿 d鈥檜n simple screening et va proposer des s茅quences mutantes de cette enzyme permettant la r茅alisation de l鈥檃ctivit茅 biologique souhait茅e.</p></div></div><div class="et_pb_module et_pb_toggle et_pb_toggle_3 et_pb_toggle_item et_pb_toggle_close"><h3 class="et_pb_toggle_title">MAD4BIO</h3><div class="et_pb_toggle_content clearfix"><p>Ce dernier module de la plateforme bioinformatique de BGene fait en partie la synth猫se de Pathway Finder, d’Host Finder et de Dezyme, notamment des r茅sultats propres 脿 chacun de ces modules. Mais au-del脿 de cette synth猫se, Mad4Bio offre la possibilit茅 de cartographier l鈥檌nt茅gralit茅 des voies m茅taboliques de l鈥檋么te retenu dans HostFinder, sous forme d鈥檜n r茅seau unique. De cette cartographie, MAD4BIO va proposer un ensemble de modifications g茅n茅tiques pour modifier ce r茅seau afin d鈥檃ugmenter et fluidifier les transformations successives du substrat vers la mol茅cule d鈥檌nt茅r锚t, 脿 la mani猫re d鈥檜n projet d鈥檜rbanisme r茅am茅nageant les flux de transports multimodaux.</p></div></div><div class="et_pb_module et_pb_text et_pb_text_5 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>Selon les projets et les besoins de nos clients, tout ou partie de nos 4 modules de bioinformatique peuvent 锚tre utilis茅s.</p></div></div></div><div class="et_pb_column et_pb_column_1_3 et_pb_column_4 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_image et_pb_image_1"> <span class="et_pb_image_wrap "><img decoding="async" width="2000" height="1333" src="https://bgene.fr/wp-content/uploads/2023/12/Le-pole-bioinformatique-de-BGene.jpg" alt="La bioinformatique est la premi猫re 茅tape de d茅veloppement chez BGene" title="Le po虃le bioinformatique de BGene" srcset="https://bgene.fr/wp-content/uploads/2023/12/Le-pole-bioinformatique-de-BGene.jpg 2000w, https://bgene.fr/wp-content/uploads/2023/12/Le-pole-bioinformatique-de-BGene-1280x853.jpg 1280w, https://bgene.fr/wp-content/uploads/2023/12/Le-pole-bioinformatique-de-BGene-980x653.jpg 980w, https://bgene.fr/wp-content/uploads/2023/12/Le-pole-bioinformatique-de-BGene-480x320.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2000px, 100vw" class="wp-image-2506" /></span></div></div></div><div class="et_pb_row et_pb_row_3"><div class="et_pb_column et_pb_column_1_3 et_pb_column_5 et_pb_css_mix_blend_mode_passthrough"><div class="et_pb_module et_pb_image et_pb_image_2"> <span class="et_pb_image_wrap "><img decoding="async" width="1354" height="1201" src="https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique2-sans-fond.png" alt="La bioinformatique est la premi猫re 茅tape de d茅veloppement chez BGene" title="__Bioinformatique2-sans fond" srcset="https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique2-sans-fond.png 1354w, https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique2-sans-fond-1280x1135.png 1280w, https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique2-sans-fond-980x869.png 980w, https://bgene.fr/wp-content/uploads/2022/07/Bioinformatique2-sans-fond-480x426.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1354px, 100vw" class="wp-image-1551" /></span></div></div><div class="et_pb_with_border et_pb_column_2_3 et_pb_column et_pb_column_6 et_pb_css_mix_blend_mode_passthrough et-last-child"><div class="et_pb_module et_pb_text et_pb_text_6 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><h2><span style="font-family: 'Esphimere Semi Bold',sans-serif;">Et apr猫s ? </span></h2></div></div><div class="et_pb_module et_pb_text et_pb_text_7 et_pb_text_align_left et_pb_bg_layout_light"><div class="et_pb_text_inner"><p>脌 l’issue de toutes ces op茅rations bioinformatiques, nous obtenons des micro-organismes et des prot茅ines optimis茅es in silico. Les 茅tapes n茅cessaires 脿 l’obtention des mol茅cules d’int茅r锚t souhait茅es par nos clients ont 茅t茅 identifi茅es et le nombre de pistes de travail a 茅t茅 r茅duit au minimum. L脿 encore, cela repr茅sente un 茅norme gain en temps et en argent, car cela r茅duit d’autant la quantit茅 d’essais 脿 r茅aliser grandeur nature.</p><p>La phase de tests de d茅veloppement peut alors commencer dans notre p么le d茅di茅 aux biotechnologies et plus particuli猫rement 脿 la fermentation de pr茅cision.</p><p>Vous avez envie de travailler avec BGene ou d’en savoir plus sur nos prestations ?</p></div></div><div class="et_pb_button_module_wrapper et_pb_button_0_wrapper et_pb_module "> <a class="et_pb_button et_pb_button_0 et_pb_bg_layout_light" href="/contact/">N'h茅sitez pas 脿 nous contacter</a></div></div></div></div></div></div></div></article></div><footer class="et-l et-l--footer"><div class="et_builder_inner_content et_pb_gutters3"><div class="et_pb_section et_pb_section_0_tb_footer et_pb_with_background et_section_regular" ><div class="et_pb_row et_pb_row_0_tb_footer"><div class="et_pb_column et_pb_column_4_4 et_pb_column_0_tb_footer et_pb_css_mix_blend_mode_passthrough 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