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It lives harmlessly on our skin and generally isn’t a problem, often disappearing without us even being aware we’ve carried it.</p> <div class="InlineElement InlineElement--Divider__container h-align-left"> <hr aria-hidden="true" class="Theme-Layer-BodyText-Divider Theme-DividerSize-xsmall Theme-BackgroundColorCustom-z47Gg2"> </div> <p class="h-align-left">However, if MRSA passes through the skin into our bodies, it can cause a major – sometimes fatal – infection. This is particularly true of hospital patients whose vulnerable surgical wounds or poor health may mean they are less able to fight it off. </p> <p class="MsoNormal h-align-left">Nationwide infection control programmes, launched in 2004, resulted in a rapid decline in MRSA cases in NHS hospitals. Since 2012, however, this decrease has plateaued – suggesting that a new approach is needed. </p> <p class="MsoNormal h-align-left">Loughborough’s <a href="https://www.lboro.ac.uk/research/experts/nacho-martin-fabiani/">Dr Nacho Martin-Fabiani</a> is investigating an exciting technological response to the challenge – antimicrobial coatings that kill bacteria before they can grow and spread.</p> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-20"></div> </div> </div> </div> </div> </div> <div class="Layer--two FullSize FullSize--fixedChild FullSize--child Theme-BackgroundMedia Theme-BackgroundImage"> <div data-lazyload-container="true" data-lazyload-trigger="true" class="FullSize--fullWidth FullSize--fullHeight Core--pointerEventsNone Lazyload Lazyload--isLoading"> <div class="FullSize Lazyload__loading" aria-hidden="true"> <picture class="FullSize--fullWidth DisplayContainerHeight FullSize--fixedChild HideOffscreen--container Theme-Item-InstantImage" aria-hidden="true" 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Theme-ForegroundColorCustom-z47Gg2"> <div class="Theme-Layer-BodyText--inner"> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-10"></div> <p class="Theme-TextSize-xxsmall"><span class="Theme-ForegroundColorCustom-z47Gg2">Dr Martin-Fabiani and his </span><a href="https://nachofabiani.net/"><span class="Theme-ForegroundColorCustom-z47Gg2">Research Group</span></a><span class="Theme-ForegroundColorCustom-z47Gg2"> are passionate about soft materials – including the polymers and liposomes that are used in a variety of everyday products like paint, adhesives, inks and cosmetics – even medicine.</span></p> <div class="InlineElement InlineElement--Divider__container h-align-left"> <hr aria-hidden="true" class="Theme-Layer-BodyText-Divider Theme-DividerSize-xsmall Theme-BackgroundColorCustom-z47Gg2"> </div> <p class="MsoNormal"><span class="Theme-ForegroundColorCustom-z47Gg2">They are particularly interested in how they can give a finished product a specific feature – for example scratch resistance, antibacterial or anti-reflective properties – simply by changing the recipe of the coating applied to its surface.</span></p> <p class="MsoNormal"><span class="Theme-ForegroundColorCustom-z47Gg2">While working at the University of Surrey (2014-16), Nacho developed a way to separate small and large particles dispersed in water, layering the smaller above the larger as the solution dries.</span></p> <p class="MsoNormal"><span class="Theme-ForegroundColorCustom-z47Gg2">By ensuring that the smaller molecules provide the characteristic sought, it is possible to create functional films (aka coatings) that have various beneficial properties – for example, killing bacteria.</span></p> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-10"></div> </div> <div class="FullSize Theme-Overlay Theme-Section-Custom Theme-BackgroundColorCustom-aLhGYa" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-OoUN6I5vCd" class="Theme-Section 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data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div class="Theme-Title"> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-20"></div> <p class="Theme-TextSize-xxsmall h-align-left">Since joining Loughborough in 2016, as a Vice-Chancellor’s Fellow, Nacho and his team have advanced his initial findings – refining the separation and layering process.</p> <div class="InlineElement InlineElement--Divider__container h-align-left"> <hr aria-hidden="true" class="Theme-Layer-BodyText-Divider Theme-DividerSize-xsmall Theme-BackgroundColorCustom-z47Gg2"> </div> <p class="h-align-left">In 2019, Nacho secured an <a href="https://gtr.ukri.org/projects?ref=EP%2FT006412%2F1">EPSRC Strategic Equipment Grant</a> and, a year later, was awarded a <a href="https://gtr.ukri.org/projects?ref=MR%2FT02061X%2F1">UKRI Future Leaders Fellowship</a> to continue his research.</p> <p class="MsoNormal h-align-left">These honours provide him and his team with state-of-the-art microscopy equipment and support for seven years’ work – applying Nacho’s technique to develop new methods for creating and testing more effective and environmentally friendly antibacterial coatings.</p> <p class="MsoNormal h-align-left">To accelerate the transition of their innovative technology to real-world applications, the multidisciplinary team are collaborating with microbiologists at Ulster University and clinical NHS colleagues, polymer chemists at the University of Lyon as well as leading paint and coating manufacturers.</p> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-20"></div> </div> </div> </div> </div> </div> <div class="Layer--two FullSize FullSize--fixedChild FullSize--child Theme-BackgroundMedia Theme-BackgroundImage"> <div data-lazyload-container="true" data-lazyload-trigger="true" class="FullSize--fullWidth FullSize--fullHeight Core--pointerEventsNone Lazyload Lazyload--isLoading"> <div class="FullSize Lazyload__loading" 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alt="Colleagues working in the AFM-FLIM facility" style="object-position:50% 50%"> </picture> </div> </div> <div class="FullSize Theme-Overlay Theme-Section-Custom Theme-ForegroundColor-4 Theme-BackgroundColorCustom-aLhGYa" style="opacity:0.75;background-color:rgba(7,11,36,1)"></div> </div> </div> <div id="section-pjH5dqubxl" class="Theme-Section Theme-TextSection Theme-Section-Position-10 Theme-Section-Layout--Full Theme-Section-Custom Theme-BackgroundColorCustom-aLhGYa Theme-ForegroundColorCustom-z47Gg2 Theme-BodyTextColumn-Center Theme-Columns--1" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsImhhc0VmZmVjdHMiOmZhbHNlLCJuZWVkc0JhY2tncm91bmRDbG9uZSI6ZmFsc2UsImVuY29kZWQiOiIifQ=="> <div class="Layer--one"> <div class="Layout"> <div class="Layout__row"> <div class="Layout__col Layout__col-lg-8 Layout__offset-lg-2 Layout__col-md-8 Layout__offset-md-2 Layout__col-sm-10 Layout__offset-sm-0 Layout__col-xs-12 Layout__offset-xs-0 Theme-Column"> <div class="Theme-Layer-BodyText Theme-ForegroundColorCustom-z47Gg2"> <div class="Theme-Layer-BodyText--inner"> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-20"></div> <p class="Theme-TextSize-xxsmall"><span class="Theme-ForegroundColorCustom-z47Gg2">Of course, this kind of research requires cutting-edge, specialist equipment. </span></p> <div class="InlineElement InlineElement--Divider__container h-align-left"> <hr aria-hidden="true" class="Theme-Layer-BodyText-Divider Theme-DividerSize-xsmall Theme-BackgroundColorCustom-z47Gg2"> </div> <p class="">The EPSRC funding that the research team received in 2019, allowed them to commission their <a href="https://nachofabiani.net/afm-cflim-facility/">AFM-FLIM lab</a>, comprising an integrated atomic force (AFM) and fluorescence lifetime imaging (FLIM) microscope with a fibre-coupled infrared detector.<br></p> <p class="">The high-spec lab supports the team’s ongoing antibacterial coatings research – and has a range of other applications within materials science as well. </p> <p class="">It can be used to measure nanoscale functionality spanning electrical, magnetic, thermal and mechanical properties – making it ideal for the development of coatings for various technologies including data and energy storage, fibre optics, medical devices, photovoltaics... <br></p> <p class="">The facility is one of just three in the UK – and the team are always happy to talk to people interested in potential collaborations, including consultancies and knowledge exchange partnerships. <br></p> <p class="">Previous collaborations include work on commercial anti-fouling coatings, photovoltaic films and biomaterials such as carotid plaques – the fatty deposits that can cause carotid artery disease. </p> <div class="Theme-Layer-BodyText-Spacer Theme-SpacerSize-20"></div> </div> <div class="FullSize Theme-Overlay Theme-Section-Custom Theme-BackgroundColorCustom-aLhGYa" style="opacity:0"></div> </div> </div> </div> </div> </div> </div> <div id="section-5ui19uGSyg" class="Theme-Section Theme-TextOverMediaSection Theme-Section-Position-11 DisplayContainerHeight--heightHalf DisplayContainerHeight--minHeightHalf DisplayContainerHeight--flex Theme-Section-Layout--Full Theme-Section-Custom Theme-BackgroundColorCustom-aLhGYa Theme-ForegroundColor-4 Theme-Section-HasOverlay" data-effects="eyJ0ZXh0UGVyTGluZSI6ZmFsc2UsInRleHRGYWRlIjoib3V0IiwiaGFzRWZmZWN0cyI6dHJ1ZSwibmVlZHNCYWNrZ3JvdW5kQ2xvbmUiOmZhbHNlLCJlbmNvZGVkIjoiIn0="> <div class="Layout FullSize--fullHeight Theme-Layer-TextBlock Layer--one"> <div class="Layout__flex--xcenter Layout__flex--ycenter Theme-Layer-TextBlock-Container" data-scrollymoly-basis="true" data-testid="ENG-5457"> <div class="Theme-Layer-TextBlock-Inner DisplayContainer--heightBasis"> <div> <div class="Theme-Title"> <h2 class="Theme-Layer-BodyText-Heading-Large Theme-Title Theme-Title Theme-Layer-BodyText-Heading-Large Theme-Title Theme-TextSize-xsmall">Potentially life-saving applications</h2> </div> </div> </div> </div> </div> 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Group are pleased with the progress of their work to date. Having refined their size segregation process, they have successfully created unique films with a range of structures.</p> <div class="InlineElement InlineElement--Divider__container h-align-left"> <hr aria-hidden="true" class="Theme-Layer-BodyText-Divider Theme-DividerSize-xsmall Theme-BackgroundColorCustom-z47Gg2"> </div> <p class="h-align-left">What’s more, the tests pitting their anti-microbial coatings against MRSA have demonstrated enhanced resistance to the superbug. Most promising is the use of titanium dioxide which kills bacteria when irradiated with UV light.</p> <p class="MsoNormal h-align-left">Meanwhile, they’re exploring the impact of adding the other materials commonly used in industrial paint formulations – things like thickeners, pigments and fillers. 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