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5th Dermatology Drug Development Europe Summit -

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itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-17579 page type-page status-publish has-post-thumbnail hentry" id="fl-post-17579" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-17579 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="17579"><div class="fl-row fl-row-full-width fl-row-bg-none fl-node-uxn01bgpoa6l fl-row-default-height fl-row-align-center" data-node="uxn01bgpoa6l"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-l2a7goyw5thr" data-node="l2a7goyw5thr"> <div class="fl-col fl-node-ipwskjvg4bry fl-col-bg-color fl-col-has-cols" data-node="ipwskjvg4bry"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-7sxi3hbnl024" data-node="7sxi3hbnl024"> <div class="fl-module-content fl-node-content"> <div class="content"> <h1 class="eehw-agenda-title"> Day Two<br /> <span><p>Thursday 18th April 2024</p> </span> </h1> <div class="inner-agenda" style="background: #e5f1ef"> <h3> <span class="time"> 8:30 am </span> <b><span style="color: #73bfb8;">Check In, Morning Coffee &#038; Light Breakfast</b> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Chair’s Opening Remarks </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #dfdeed"> <h3> <span class="time"> </span> <center><span style="color:#090528">Towards First-in-Human: Taking Compounds to the Clinic</center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:45 am </span> Development of a Topical Containing a Non-Coding Oligonucleotide </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://dermatology-drugdevelopment-europe.com/speakers/#speaker22728" class="view-speaker" speaker-id="22728"><span>Anna-Lena Spetz</span></a></em> Chief Scientific Officer & founder, TIRmed </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="font-size: 14px;">• Proof-of-concept study in canines with atopic dermatitis</span></p> <p><span style="font-size: 14px;">• Cutaneous CD11b+ cells that inhibit Th1/2/9 responses and promote Tregs are recruited by a non-coding oligonucleotide</span></p> <p><span style="font-size: 14px;">• Upregulation of immune-checkpoint proteins on cutaneous CD11b+ cells</span></p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:15 am </span> Pearls of Perfect Efficacy Data in Dermatology Clinical Trialsx </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://dermatology-drugdevelopment-europe.com/speakers/#speaker23235" class="view-speaker" speaker-id="23235"><span>Tatjana Checherska</span></a></em> Senior medical director, Parexel International Corporation </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Efficacy data in dermatology clinical trials (Hidradenitis Suppurativa and Psoriasis)</li> <li>Main concerns and ways to monitor</li> <li>Lessons learned</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #e5f1ef"> <h3> <span class="time"> 10:45 am </span> <b><span style="color: #73bfb8;"> Morning Break &#038; Networking</b> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="font-size: 14px;">Meet and connect with your peers in this dedicated networking session</span></p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #dfdeed"> <h3> <span class="time"> </span> <center><span style="color:#090528">Clinical Strategies in Dermatology: Clinical Progress &#038; Novel Strategies Shaping Today’s Drug Development Landscape</center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:45 am </span> Rezpegaldesleukin, a Regulatory T-Cell Selective IL-2 Conjugate: Lessons Learned From Preclinical Design to Clinical Evaluation in Inflammatory Skin Diseases Including Atopic Dermatitis </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://dermatology-drugdevelopment-europe.com/speakers/#speaker22724" class="view-speaker" speaker-id="22724"><span>Jonathan Zalevsky</span></a></em> Chief Research & Development Officer, Nektar Therapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="font-size: 14px;">• Use of the appropriate design elements and experimental models for generation and preclinical evaluation</span></p> <p><span style="font-size: 14px;">• Using clinical development approaches to address target engagement and assess PK/PD principles</span></p> <p><span style="font-size: 14px;">• Using clinical studies to identify the correlation between the MOA and the indication</span></p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:15 pm </span> Expanding the Role of the IL-17A &#038; IL-17F inhibiting Nanobody® Sonelokimab Across Derm &#038; Rheum Indications – Data from a Global Placebo- &#038; Active Comparator-Controlled Phase 2 Study in Psoriatic Arthritis </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://dermatology-drugdevelopment-europe.com/speakers/#speaker22733" class="view-speaker" speaker-id="22733"><span>Kristian Reich</span></a></em> Chief Scientific Officer, MoonLake Immunotherapeutics </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Explore the rapid achievement of high response levels in joints and skin across ACR and PASI thresholds, as well as composite measures such as MDA, shedding light on the dynamics of clinical response patterns </li> <li>Consistent safety results observed in the ARGO and previous sonelokimab trials, emphasising the absence of new safety signals and contributing additional insights into the safety profile of IL-17 inhibitors</li> <li>Investigate the broader impact of sonelokimab on patient-reported quality of life, and across psoriatic disease domains, examining the depth of response beyond the primary endpoint, and its significance in the context of improving the overall well-being of patients</li> </ul> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #e5f1ef"> <h3> <span class="time"> 12:45 pm </span> <b><span style="color: #73bfb8;">Lunch Break</b> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="font-size: 14px;">Take this chance to meet the expert speakers, connect with your peers and explore our exhibition booths</span></p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #dfdeed"> <h3> <span class="time"> </span> <center><span style="color:#090528">Navigating European Healthcare Infrastructure: Enabling Accuracy in Diagnosis &#038; Expanding Access to Novel Therapeutics</center></span> </h3> <!-- Speaker List --> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: #e5f1ef"> <h3> <span class="time"> 1:45 pm </span> <b><span style="color: #033294;">Roundtable Discussion</span>:Navigating &#038; Re-Thinking Market Access Strategies in European Dermatology Drug Development </b> </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://dermatology-drugdevelopment-europe.com/speakers/#speaker22714" class="view-speaker" speaker-id="22714"><span>Thorsten Thormann</span></a></em> Stretegic Advisor, Independant Consultant </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="font-size: 14px;">In the dynamic landscape of dermatology drug development, securing successful market</span></p> <p><span style="font-size: 14px;">access in Europe is a pivotal milestone for biopharma innovators. This interactive discussion brings together large pharma, biotech, clinician and market access strategists to delve into the crucial considerations for planning ahead in this complex journey in a more informed manner compared to today. </span></p> <p></p> <p><span style="font-size: 14px;">Use this opportunity to discuss the intricacies of European regulatory, HTA criteria and payer engagement strategies to optimise development timelines, approval processes, craft reimbursement models and ultimately navigate diverse markets to maximise patient access to novel therapies.</span></p> <p><span style="font-size: 14px;"></span></p> <p><strong style="font-size: 14px;">Join us for a collaborative exploration of strategies and insights that will empower</strong></p> <p><strong style="font-size: 14px;">your end-to-end dermatology drug development journey in the European market!</strong></p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:45 pm </span> Adopting Novel Strategies for Chronic Skin Conditions in Clinical Practice </h3> <!-- Speaker List --> <ul class="non-expand-speaker-list"> <li> <em><a href="https://dermatology-drugdevelopment-europe.com/speakers/#speaker22735" class="view-speaker" speaker-id="22735"><span>Elisabeth Riedl</span></a></em> Associate Professor - Department of Dermatology, Medical University of Vienna </li> </ul> <!-- /Speaker List --> <div class="clearfix"></div> <!-- Agenda content --> <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="font-size: 14px;">• Given the latest developments and approvals of new treatments in dermatology, are these therapies proving effective and safe when applied in real-world clinical scenarios?</span></p> <p><span style="font-size: 14px;">• Are the newly available treatments in dermatology leading to sustained improvements in patients’ quality of life over time?</span></p> <p><span style="font-size: 14px;">• How can learnings from clinical practice inform future research and the evolution towards a personalised medicine approach in treating dermatologic conditions?</span></p> </div> <!-- /Agenda content --> </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:15 pm </span> Chair’s Closing Remarks &#038; 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activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba1fe150af69',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, -'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} 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image=$(this),height=image.height(),node=image.closest('.fl-module').data('node'),className='fl-node-'+node+'-img-'+i,maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.addClass(className);styles+='.'+className+' { max-height: '+(height?height:image[0].height)+'px }';}});if(''!==styles){head.append('<style id="'+stylesId+'">'+styles+'</style>');}},_removeImageMaxHeight:function(){$('#fl-header-styles-'+this.header.data('post-id')).remove();},};$(function(){FLThemeBuilderHeaderLayout.init();});})(jQuery);</script></body> </html> <!-- Page cached by LiteSpeed Cache 6.5.2 on 2024-11-25 22:17:45 -->

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