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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73933243/Indoor_fungal_diversity_in_primary_schools_may_differently_influence_allergic_sensitization_and_asthma_in_children">Indoor fungal diversity in primary schools may differently influence allergic sensitization and asthma in children</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Childhood exposure to microbiological agents may influence the development of allergic and respiratory diseases. Apart from home, children spend most of their time at school, which represents an environment of significant exposure to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73933243" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Childhood exposure to microbiological agents may influence the development of allergic and respiratory diseases. Apart from home, children spend most of their time at school, which represents an environment of significant exposure to indoor air microbes. Therefore, we aimed to assess how the prevalence of allergic sensitization and asthma in schoolchildren is affected by microbiological exposure within classrooms. Spirometry with bronchodilation, exhaled nitric oxide measurements and skin-prick tests data were retrieved from 858 children aged 8 to 10 years old attending 71 classrooms in 20 primary schools. Air samples were collected in all classrooms using a single-stage microbiological air impactor through agar plates. Gram-negative endotoxins were collected using flow control pumps and analysed by limulus amebocyte lysate assay. Diversity scores were established as the number of different fungal species found in each classroom. Classrooms with increased diversity scores showed a s...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73933243" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="935959b6da0984fa14b86859c88856c7" rel="nofollow" data-download="{"attachment_id":82269853,"asset_id":73933243,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82269853/download_file?st=MTczMjM4MTEyNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="56242989" href="https://independent.academia.edu/Patr%C3%ADciaPadr%C3%A3o">Patrícia Padrão</a><script data-card-contents-for-user="56242989" type="text/json">{"id":56242989,"first_name":"Patrícia","last_name":"Padrão","domain_name":"independent","page_name":"PatríciaPadrão","display_name":"Patrícia Padrão","profile_url":"https://independent.academia.edu/Patr%C3%ADciaPadr%C3%A3o?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73933243 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73933243"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73933243, container: ".js-paper-rank-work_73933243", }); 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Apart from home, children spend most of their time at school, which represents an environment of significant exposure to indoor air microbes. Therefore, we aimed to assess how the prevalence of allergic sensitization and asthma in schoolchildren is affected by microbiological exposure within classrooms. Spirometry with bronchodilation, exhaled nitric oxide measurements and skin-prick tests data were retrieved from 858 children aged 8 to 10 years old attending 71 classrooms in 20 primary schools. Air samples were collected in all classrooms using a single-stage microbiological air impactor through agar plates. Gram-negative endotoxins were collected using flow control pumps and analysed by limulus amebocyte lysate assay. Diversity scores were established as the number of different fungal species found in each classroom. Classrooms with increased diversity scores showed a s...","downloadable_attachments":[{"id":82269853,"asset_id":73933243,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":56242989,"first_name":"Patrícia","last_name":"Padrão","domain_name":"independent","page_name":"PatríciaPadrão","display_name":"Patrícia Padrão","profile_url":"https://independent.academia.edu/Patr%C3%ADciaPadr%C3%A3o?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":1444,"name":"Environmental microbiology","url":"https://www.academia.edu/Documents/in/Environmental_microbiology?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false},{"id":14911,"name":"Asthma In 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data-work_id="45417394" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45417394/Food_allergy_and_the_introduction_of_solid_foods_to_infants_a_consensus_document">Food allergy and the introduction of solid foods to infants: a consensus document</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/45417394" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d77aebc1bb8d1b2b062803d8c581659c" 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type="text/json">{"id":114304200,"first_name":"Alessandro","last_name":"Fiocchi","domain_name":"independent","page_name":"FiocchiA","display_name":"Alessandro Fiocchi","profile_url":"https://independent.academia.edu/FiocchiA?f_ri=168977","photo":"https://0.academia-photos.com/114304200/43801891/34689330/s65_alessandro.fiocchi.jpg"}</script></span></span></li><li class="js-paper-rank-work_45417394 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="45417394"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 45417394, container: ".js-paper-rank-work_45417394", }); });</script></li><li class="js-percentile-work_45417394 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x 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}); });</script></span><script>$(function() { $(".js-view-count-work_45417394").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="45417394"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3645" href="https://www.academia.edu/Documents/in/Evidence_Based_Medicine">Evidence Based Medicine</a>, <script data-card-contents-for-ri="3645" type="text/json">{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9478" href="https://www.academia.edu/Documents/in/Diet">Diet</a>, <script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47258" href="https://www.academia.edu/Documents/in/Food_Allergy">Food Allergy</a><script data-card-contents-for-ri="47258" type="text/json">{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=45417394]'), work: {"id":45417394,"title":"Food allergy and the introduction of solid foods to 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class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5217925/A_prospective_Italian_survey_on_the_safety_of_subcutaneous_immunotherapy_for_respiratory_allergy">A prospective Italian survey on the safety of subcutaneous immunotherapy for respiratory allergy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background Subcutaneous immunotherapy is effective for the treatment of respiratory allergy, and it is largely used in Italy, but no systematic safety assessment has been carried out so far.Objective To assess prospectively the safety of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5217925" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background Subcutaneous immunotherapy is effective for the treatment of respiratory allergy, and it is largely used in Italy, but no systematic safety assessment has been carried out so far.Objective To assess prospectively the safety of injection immunotherapy in a multicentre, real-life survey.Methods Eleven Italian allergy departments recorded the clinical characteristics of systemic reactions (SRs) due to immunotherapy. Vaccines were prescribed according to guidelines; only standardized depot extracts were used. SRs were graded according to the EAACI recommendations, and were classified as immediate or delayed.Results One thousand seven hundred and thirty-eight patients (847 males, age range 5–71) received immunotherapy from eight different manufacturers, for a total of 2038 courses (300 patients received two extracts). A total of 60 785 injections were given over a mean immunotherapy duration of 3 years. Overall, 95 reactions were observed in 57 patients (3.28%), corresponding to 4.7% of the courses and 1.56/1000 injections. Twenty-five patients experienced more than one adverse event. There were 34 grade 2, 60 grade 3 and one grade 4 reactions and no fatality. SRs occurred more frequently in patients with asthma than in patients with rhinitis alone (4.1% vs. 1.1%), and were equally distributed between the build-up and the maintenance phase. Ragweed and grass extracts caused significantly more side effects than other allergens.Conclusion In this large prospective study, the rate of SRs was low, thus confirming that injection immunotherapy has an acceptable risk/benefit ratio when prescribed and carried out according to recommendations.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5217925" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c39694fa8ab452a146ed6f316bd3276c" rel="nofollow" data-download="{"attachment_id":49395804,"asset_id":5217925,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49395804/download_file?st=MTczMjM4MTEyNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7112248" href="https://ucalgary.academia.edu/AlessandroMassolo">Alessandro Massolo</a><script data-card-contents-for-user="7112248" type="text/json">{"id":7112248,"first_name":"Alessandro","last_name":"Massolo","domain_name":"ucalgary","page_name":"AlessandroMassolo","display_name":"Alessandro Massolo","profile_url":"https://ucalgary.academia.edu/AlessandroMassolo?f_ri=168977","photo":"https://0.academia-photos.com/7112248/3097602/3645498/s65_alessandro.massolo.jpg"}</script></span></span></li><li class="js-paper-rank-work_5217925 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5217925"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5217925, container: ".js-paper-rank-work_5217925", }); 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$(".js-view-count[data-work-id=5217925]").text(description); $(".js-view-count-work_5217925").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_5217925").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5217925"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4365" href="https://www.academia.edu/Documents/in/Vaccines">Vaccines</a>, <script data-card-contents-for-ri="4365" type="text/json">{"id":4365,"name":"Vaccines","url":"https://www.academia.edu/Documents/in/Vaccines?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5217925]'), work: {"id":5217925,"title":"A prospective Italian survey on the safety of subcutaneous immunotherapy for respiratory allergy","created_at":"2013-11-25T11:04:54.902-08:00","url":"https://www.academia.edu/5217925/A_prospective_Italian_survey_on_the_safety_of_subcutaneous_immunotherapy_for_respiratory_allergy?f_ri=168977","dom_id":"work_5217925","summary":"Background Subcutaneous immunotherapy is effective for the treatment of respiratory allergy, and it is largely used in Italy, but no systematic safety assessment has been carried out so far.Objective To assess prospectively the safety of injection immunotherapy in a multicentre, real-life survey.Methods Eleven Italian allergy departments recorded the clinical characteristics of systemic reactions (SRs) due to immunotherapy. Vaccines were prescribed according to guidelines; only standardized depot extracts were used. SRs were graded according to the EAACI recommendations, and were classified as immediate or delayed.Results One thousand seven hundred and thirty-eight patients (847 males, age range 5–71) received immunotherapy from eight different manufacturers, for a total of 2038 courses (300 patients received two extracts). A total of 60 785 injections were given over a mean immunotherapy duration of 3 years. Overall, 95 reactions were observed in 57 patients (3.28%), corresponding to 4.7% of the courses and 1.56/1000 injections. Twenty-five patients experienced more than one adverse event. There were 34 grade 2, 60 grade 3 and one grade 4 reactions and no fatality. SRs occurred more frequently in patients with asthma than in patients with rhinitis alone (4.1% vs. 1.1%), and were equally distributed between the build-up and the maintenance phase. Ragweed and grass extracts caused significantly more side effects than other allergens.Conclusion In this large prospective study, the rate of SRs was low, thus confirming that injection immunotherapy has an acceptable risk/benefit ratio when prescribed and carried out according to recommendations.","downloadable_attachments":[{"id":49395804,"asset_id":5217925,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7112248,"first_name":"Alessandro","last_name":"Massolo","domain_name":"ucalgary","page_name":"AlessandroMassolo","display_name":"Alessandro 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href="https://www.academia.edu/21443481/Circulating_eosinophil_basophil_progenitors_and_nasal_mucosal_cytokines_in_seasonal_allergic_rhinitis">Circulating eosinophil/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21443481" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="465a31af874399609f184411c53b6cd5" rel="nofollow" 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u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In patients given a diagnosis of chronic spontaneous urticaria (CSU), there are no obvious external triggers, and the factors that initiate the clinical symptoms of wheal, flare, and itch arise from within the patient. Most patients with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18902809" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In patients given a diagnosis of chronic spontaneous urticaria (CSU), there are no obvious external triggers, and the factors that initiate the clinical symptoms of wheal, flare, and itch arise from within the patient. Most patients with CSU have an autoimmune cause: some patients produce IgE autoantibodies against autoantigens, such as thyroperoxidase or double-stranded DNA, whereas other patients make IgG autoantibodies against FcεRI, IgE, or both, which might chronically activate mast cells and basophils. In the remainder of patients with CSU, the nature of the abnormalities has not yet been identified. Accumulating evidence has shown that IgE, by binding to FcεRI on mast cells without FcεRI cross-linking, can promote the proliferation and survival of mast cells and thus maintain and expand the pool of mast cells. IgE and FcεRI engagement can also decrease the release threshold of mast cells and increase their sensitivity to various stimuli through either FcεRI or other receptors...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18902809" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e793a2cae09745ed28eb2bc326f9178e" rel="nofollow" data-download="{"attachment_id":40319997,"asset_id":18902809,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40319997/download_file?st=MTczMjM4MTEyNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39027220" href="https://charite-de.academia.edu/MarcusMaurer">Marcus Maurer</a><script data-card-contents-for-user="39027220" type="text/json">{"id":39027220,"first_name":"Marcus","last_name":"Maurer","domain_name":"charite-de","page_name":"MarcusMaurer","display_name":"Marcus Maurer","profile_url":"https://charite-de.academia.edu/MarcusMaurer?f_ri=168977","photo":"https://0.academia-photos.com/39027220/11464973/12787791/s65_marcus.maurer.jpg"}</script></span></span></li><li class="js-paper-rank-work_18902809 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18902809"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18902809, container: ".js-paper-rank-work_18902809", }); 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Most patients with CSU have an autoimmune cause: some patients produce IgE autoantibodies against autoantigens, such as thyroperoxidase or double-stranded DNA, whereas other patients make IgG autoantibodies against FcεRI, IgE, or both, which might chronically activate mast cells and basophils. In the remainder of patients with CSU, the nature of the abnormalities has not yet been identified. Accumulating evidence has shown that IgE, by binding to FcεRI on mast cells without FcεRI cross-linking, can promote the proliferation and survival of mast cells and thus maintain and expand the pool of mast cells. IgE and FcεRI engagement can also decrease the release threshold of mast cells and increase their sensitivity to various stimuli through either FcεRI or other receptors...","downloadable_attachments":[{"id":40319997,"asset_id":18902809,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39027220,"first_name":"Marcus","last_name":"Maurer","domain_name":"charite-de","page_name":"MarcusMaurer","display_name":"Marcus Maurer","profile_url":"https://charite-de.academia.edu/MarcusMaurer?f_ri=168977","photo":"https://0.academia-photos.com/39027220/11464973/12787791/s65_marcus.maurer.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":12320,"name":"Autoimmunity","url":"https://www.academia.edu/Documents/in/Autoimmunity?f_ri=168977","nofollow":false},{"id":12426,"name":"Treatment 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18010430/Allergic_rhinitis_and_asthma_comorbidity_ARIA_classification_of_rhinitis_does_not_correlate_with_the_prevalence_of_asthma">Allergic rhinitis and asthma comorbidity: ARIA classification of rhinitis does not correlate with the prevalence of asthma</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Allergic rhinitis and asthma comorbidity is supported by both the similar underlying pathogenesis and immunologic mechanisms. The aim of this study was to verify whether the characteristics of rhinitis classified according to the new... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18010430" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Allergic rhinitis and asthma comorbidity is supported by both the similar underlying pathogenesis and immunologic mechanisms. The aim of this study was to verify whether the characteristics of rhinitis classified according to the new Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines correlate with the prevalence of asthma. From 1 March to 30 June 2002, a multi-centre cross-sectional study was conducted by 154 allergists chosen from throughout Italy. Duration, severity of rhinitis (according to the ARIA classification) and the type of allergic sensitizations were compared with the prevalence of asthma. One thousand three hundred and twenty-one consecutive rhinitis-allergic patients aged 18 years or older were enrolled for the study. The majority of patients, 1060 (80.24%), were on medication at the time of their specialist visit. Mild intermittent rhinitis was diagnosed in 7.7% of patients, moderate/severe intermittent in 17.1%, mild persistent in 11.6%, and moderate/severe persistent in 63.6%. The prevalence of asthma was 48% in patients with mild intermittent rhinitis, 49.6% in moderate-severe intermittent rhinitis, 36.6% in mild persistent rhinitis and 47.5% in moderate severe persistent patients. No correlation between the ARIA categories of rhinitis and the prevalence of asthma was found. A multivariate analysis, after adjustment for age, sex, type of sensitization, level of severity and duration of rhinitis classified according to the ARIA guidelines, demonstrated that age, over 41 years [risk ratio (RR) 1.260, 95% confidence interval (CI) 1.072-1.482] and especially over 51 years (RR 1.460, 95% CI 1.237-1.723), sensitization to indoor allergens (mite and cat), (RR 1.203, 95% CI 1.060-1.366), and polysensitization (RR 1.178, 95% CI 1.004-1.383) are significant risk factors for asthma. In allergic rhinitis (AR) patients referred to a specialist, the features of AR as defined by the ARIA classification are not able to predict the presence of asthma, therefore all such patients should be assessed for asthma.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18010430" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8886c7cd62baa4dae53129b9032f1ede" rel="nofollow" data-download="{"attachment_id":42206733,"asset_id":18010430,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42206733/download_file?st=MTczMjM4MTEyNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37941771" href="https://independent.academia.edu/SusannaVoltolini">Susanna Voltolini</a><script data-card-contents-for-user="37941771" type="text/json">{"id":37941771,"first_name":"Susanna","last_name":"Voltolini","domain_name":"independent","page_name":"SusannaVoltolini","display_name":"Susanna Voltolini","profile_url":"https://independent.academia.edu/SusannaVoltolini?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18010430 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18010430"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18010430, container: ".js-paper-rank-work_18010430", }); 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The aim of this study was to verify whether the characteristics of rhinitis classified according to the new Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines correlate with the prevalence of asthma. From 1 March to 30 June 2002, a multi-centre cross-sectional study was conducted by 154 allergists chosen from throughout Italy. Duration, severity of rhinitis (according to the ARIA classification) and the type of allergic sensitizations were compared with the prevalence of asthma. One thousand three hundred and twenty-one consecutive rhinitis-allergic patients aged 18 years or older were enrolled for the study. The majority of patients, 1060 (80.24%), were on medication at the time of their specialist visit. Mild intermittent rhinitis was diagnosed in 7.7% of patients, moderate/severe intermittent in 17.1%, mild persistent in 11.6%, and moderate/severe persistent in 63.6%. The prevalence of asthma was 48% in patients with mild intermittent rhinitis, 49.6% in moderate-severe intermittent rhinitis, 36.6% in mild persistent rhinitis and 47.5% in moderate severe persistent patients. No correlation between the ARIA categories of rhinitis and the prevalence of asthma was found. A multivariate analysis, after adjustment for age, sex, type of sensitization, level of severity and duration of rhinitis classified according to the ARIA guidelines, demonstrated that age, over 41 years [risk ratio (RR) 1.260, 95% confidence interval (CI) 1.072-1.482] and especially over 51 years (RR 1.460, 95% CI 1.237-1.723), sensitization to indoor allergens (mite and cat), (RR 1.203, 95% CI 1.060-1.366), and polysensitization (RR 1.178, 95% CI 1.004-1.383) are significant risk factors for asthma. 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href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="27521" href="https://www.academia.edu/Documents/in/Stents">Stents</a>, <script data-card-contents-for-ri="27521" type="text/json">{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="168977" href="https://www.academia.edu/Documents/in/Allergens">Allergens</a><script 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Diseases","url":"https://www.academia.edu/Documents/in/Heart_Diseases?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26690240 coauthored" data-work_id="26690240" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26690240/Allergic_contact_dermatitis_caused_by_epoxy_resin_systems_in_industrial_painters">Allergic contact dermatitis caused by epoxy resin systems in industrial painters</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26690240" data-share-source="work_strip" 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13555096/Allergic_conjunctivitis_in_asthmatic_children_as_common_as_underreported">Allergic conjunctivitis in asthmatic children: as common as underreported</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13555096" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f3e9e9433e99b52a4c6643fcd9ddda24" rel="nofollow" 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u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" 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symptoms of allergic rhinitis (AR) can disrupt school and leisure activities, significantly reducing quality of life. Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24023180" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Acute and chronic symptoms of allergic rhinitis (AR) can disrupt school and leisure activities, significantly reducing quality of life. Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR perform significantly worse in summer exams, relative to their mock exam results, when compared with their peers. Those individuals showing most symptoms are also likely to be affected by other allergic diseases, magnifying the detrimental impact on quality of life. Nasal blockage is the most common complaint associated with chronic AR, with acute exacerbations causing sneezing, clear nasal discharge and itchy eyes following exposure to the relevant airborne triggers. Allergen avoidance measures should be instituted according to seasonal or perennial symptomatology guided by allergy testing, alongside nonsedating antihistamines such as cetirizine or loratadine. Continued symptoms should be treated with regular intranasal steroid spray. Anti-leukotri...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24023180" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ba8dce54bbb09214b9f523c07d079990" rel="nofollow" data-download="{"attachment_id":44400952,"asset_id":24023180,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44400952/download_file?st=MTczMjM4MTEyNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46374782" href="https://independent.academia.edu/TomMarrs">Tom Marrs</a><script data-card-contents-for-user="46374782" type="text/json">{"id":46374782,"first_name":"Tom","last_name":"Marrs","domain_name":"independent","page_name":"TomMarrs","display_name":"Tom Marrs","profile_url":"https://independent.academia.edu/TomMarrs?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24023180 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24023180"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24023180, container: ".js-paper-rank-work_24023180", }); 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Symptoms often impair sleep, resulting in tiredness and poor concentration. Children with seasonal AR perform significantly worse in summer exams, relative to their mock exam results, when compared with their peers. Those individuals showing most symptoms are also likely to be affected by other allergic diseases, magnifying the detrimental impact on quality of life. Nasal blockage is the most common complaint associated with chronic AR, with acute exacerbations causing sneezing, clear nasal discharge and itchy eyes following exposure to the relevant airborne triggers. Allergen avoidance measures should be instituted according to seasonal or perennial symptomatology guided by allergy testing, alongside nonsedating antihistamines such as cetirizine or loratadine. Continued symptoms should be treated with regular intranasal steroid spray. 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u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22177407/Investigation_of_an_Allergen_Adsorption_on_Amine_and_Acid_Terminated_Thiol_Layers_Influence_on_Their_Affinity_to_Specific_Antibodies">Investigation of an Allergen Adsorption on Amine- and Acid-Terminated Thiol Layers: Influence on Their Affinity to Specific Antibodies</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22177407" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a91d2a3bb2aa044b795afd6ec990c3b9" rel="nofollow" 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href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="246560" href="https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography">High Pressure Liquid Chromatography</a><script data-card-contents-for-ri="246560" type="text/json">{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17898436]'), work: {"id":17898436,"title":"Variation in allergen content over time of acrylates/methacrylates in patch test 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Methacrylates","url":"https://www.academia.edu/Documents/in/Polymethyl_Methacrylates?f_ri=168977"},{"id":1171968,"name":"Patch Tests","url":"https://www.academia.edu/Documents/in/Patch_Tests?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16595614" data-work_id="16595614" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16595614/Ecology_and_elimination_of_cockroaches_and_allergens_in_the_home">Ecology and elimination of cockroaches and allergens in the home</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cockroach infestations have been indicated as a major contributor to asthma throughout the world. Several studies have shown that large numbers of asthmatic patients are sensitized to cockroach allergens. Eliminating this pest from homes,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16595614" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cockroach infestations have been indicated as a major contributor to asthma throughout the world. Several studies have shown that large numbers of asthmatic patients are sensitized to cockroach allergens. Eliminating this pest from homes, schools, and public buildings involves a long-term commitment to a rational extermination process. This article covers the characteristics of the major cockroach species that invade homes, assesses the role of environmental exposure to cockroaches in asthma, and provides an intervention program for their extermination.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16595614" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5d9b6930097e24cff7ef015bbceccd4e" rel="nofollow" data-download="{"attachment_id":42429223,"asset_id":16595614,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42429223/download_file?st=MTczMjM4MTEyNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35922347" href="https://independent.academia.edu/PeytonEggleston">Peyton Eggleston</a><script data-card-contents-for-user="35922347" type="text/json">{"id":35922347,"first_name":"Peyton","last_name":"Eggleston","domain_name":"independent","page_name":"PeytonEggleston","display_name":"Peyton Eggleston","profile_url":"https://independent.academia.edu/PeytonEggleston?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16595614 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16595614"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16595614, container: ".js-paper-rank-work_16595614", }); 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However, not all subjects affected by this allergy are IgE-positive to tropomyosin. To... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13106000" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Allergy to crustacean shellfish is one of the most common IgE-mediated food allergies, and tropomyosin has been identified as the major allergen. However, not all subjects affected by this allergy are IgE-positive to tropomyosin. To evaluate whether sera of patients with shrimp allergy but negative for tropomyosin react to other allergen(s); and to evaluate the role such allergen(s) may play in cross-reactivity between crustaceans and house dust mites (HDMs). Three different pools of sera-one from subjects with shellfish allergy and HDMs positivity, but negative for recombinant and native tropomyosin (rPen a 1 and nPen m 1) (Pool 2); a second from subjects with tropomyosin and HDMs positivity (Pool 1); and the last from subjects allergic only to HDMs (Pool 3) were submitted to immunoblotting. Subsequently, a 20 kDa protein- enriched fraction of shrimp extract was used at two different concentrations (10 and 100 microg/mL) to pre-absorb the Pool 2 serum and to evaluate, by ELISA assa...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13106000" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="33e023a30d71fe8a77d006f9bb06a6ef" rel="nofollow" data-download="{"attachment_id":45661684,"asset_id":13106000,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45661684/download_file?st=MTczMjM4MTEyNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32356658" href="https://independent.academia.edu/NicolaBizzaro">Nicola Bizzaro</a><script data-card-contents-for-user="32356658" type="text/json">{"id":32356658,"first_name":"Nicola","last_name":"Bizzaro","domain_name":"independent","page_name":"NicolaBizzaro","display_name":"Nicola Bizzaro","profile_url":"https://independent.academia.edu/NicolaBizzaro?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13106000 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13106000"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13106000, container: ".js-paper-rank-work_13106000", }); 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However, not all subjects affected by this allergy are IgE-positive to tropomyosin. To evaluate whether sera of patients with shrimp allergy but negative for tropomyosin react to other allergen(s); and to evaluate the role such allergen(s) may play in cross-reactivity between crustaceans and house dust mites (HDMs). Three different pools of sera-one from subjects with shellfish allergy and HDMs positivity, but negative for recombinant and native tropomyosin (rPen a 1 and nPen m 1) (Pool 2); a second from subjects with tropomyosin and HDMs positivity (Pool 1); and the last from subjects allergic only to HDMs (Pool 3) were submitted to immunoblotting. Subsequently, a 20 kDa protein- enriched fraction of shrimp extract was used at two different concentrations (10 and 100 microg/mL) to pre-absorb the Pool 2 serum and to evaluate, by ELISA assa...","downloadable_attachments":[{"id":45661684,"asset_id":13106000,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32356658,"first_name":"Nicola","last_name":"Bizzaro","domain_name":"independent","page_name":"NicolaBizzaro","display_name":"Nicola Bizzaro","profile_url":"https://independent.academia.edu/NicolaBizzaro?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=168977","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=168977","nofollow":false},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977","nofollow":false},{"id":176180,"name":"Immunoglobulin 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of Novel Cytokine IL-38 and Regulatory T Lymphocytes in Childhood Asthma</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We investigated the expression of novel anti-inflammatory interleukin (IL)-38 and regulatory T (Treg) lymphocytes in childhood asthma patients. The protein and mRNA expression level of IL-38, periostin, peripheral CD4⁺CD25⁺CD134⁺ T... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49363040" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We investigated the expression of novel anti-inflammatory interleukin (IL)-38 and regulatory T (Treg) lymphocytes in childhood asthma patients. The protein and mRNA expression level of IL-38, periostin, peripheral CD4⁺CD25⁺CD134⁺ T lymphocytes as well as CD4⁺CD25(high)FoxP3⁺ and CD4⁺CD25(high)CD127(-) Treg lymphocytes from 40 asthmatic patients and 20 normal control (NC) subjects were studied using ELISA, qPCR and flow cytometry. Serum and supernatant cytokines/chemokines were determined by multiplex assay. Serum IL-38, IL-5, IL-17, IL-6, interferon-γ, periostin, IL-1β and IL-13 concentrations were significantly higher in asthmatic patients with or without steroid treatment than those in controls (all p &lt; 0.05). The percentages of both CD4⁺CD25(high)FoxP3⁺ and CD4⁺CD25(high)CD127(-) Treg lymphocytes were markedly decreased in asthmatic patients with and without steroid treatment than those in controls (all p &lt; 0.05). The elevated IL-38 concentration negatively correlated with ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49363040" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="57441a05ae7492552537e9b05479e962" rel="nofollow" data-download="{"attachment_id":67740067,"asset_id":49363040,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67740067/download_file?st=MTczMjM4MTEyNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34198505" href="https://independent.academia.edu/ChunWong6">Chun Wong</a><script data-card-contents-for-user="34198505" type="text/json">{"id":34198505,"first_name":"Chun","last_name":"Wong","domain_name":"independent","page_name":"ChunWong6","display_name":"Chun Wong","profile_url":"https://independent.academia.edu/ChunWong6?f_ri=168977","photo":"https://0.academia-photos.com/34198505/121027361/110357078/s65_chun.wong.jpeg"}</script></span></span></li><li class="js-paper-rank-work_49363040 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49363040"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49363040, container: ".js-paper-rank-work_49363040", }); 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The protein and mRNA expression level of IL-38, periostin, peripheral CD4⁺CD25⁺CD134⁺ T lymphocytes as well as CD4⁺CD25(high)FoxP3⁺ and CD4⁺CD25(high)CD127(-) Treg lymphocytes from 40 asthmatic patients and 20 normal control (NC) subjects were studied using ELISA, qPCR and flow cytometry. Serum and supernatant cytokines/chemokines were determined by multiplex assay. Serum IL-38, IL-5, IL-17, IL-6, interferon-γ, periostin, IL-1β and IL-13 concentrations were significantly higher in asthmatic patients with or without steroid treatment than those in controls (all p \u0026lt; 0.05). The percentages of both CD4⁺CD25(high)FoxP3⁺ and CD4⁺CD25(high)CD127(-) Treg lymphocytes were markedly decreased in asthmatic patients with and without steroid treatment than those in controls (all p \u0026lt; 0.05). The elevated IL-38 concentration negatively correlated with ...","downloadable_attachments":[{"id":67740067,"asset_id":49363040,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34198505,"first_name":"Chun","last_name":"Wong","domain_name":"independent","page_name":"ChunWong6","display_name":"Chun Wong","profile_url":"https://independent.academia.edu/ChunWong6?f_ri=168977","photo":"https://0.academia-photos.com/34198505/121027361/110357078/s65_chun.wong.jpeg"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=168977","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false},{"id":27784,"name":"Gene 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carpets in New Zealand homes</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21700649" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ba1442539fc9e979bc60d2bfd6292902" rel="nofollow" data-download="{"attachment_id":42405648,"asset_id":21700649,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a><script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21700649]'), work: {"id":21700649,"title":"The importance of housing characteristics in determining Der p 1 levels in carpets in New Zealand 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