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class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Anthony Bullock</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://sheffield.academia.edu/">The University of Sheffield</a>, <a class="u-tcGrayDarker" href="https://sheffield.academia.edu/Departments/Material_Science_and_Engineering/Documents">Material Science and Engineering</a>, <span class="u-tcGrayDarker">Post-Doc</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Anthony" data-follow-user-id="33365251" data-follow-user-source="profile_button" 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data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">10</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="33365251">View All (6)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33365251" href="https://www.academia.edu/Documents/in/TRENDS"><div id="js-react-on-rails-context" style="display:none" 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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Anthony Bullock</h3></div><div class="js-work-strip profile--work_container" data-work-id="114507429"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507429/Chiral_Regioisomers_of_INS_1_4_5_P_3_Structure_Activity_Profile"><img alt="Research paper thumbnail of Chiral Regioisomers of INS(1,4,5)P-3 - Structure-Activity Profile" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507429/Chiral_Regioisomers_of_INS_1_4_5_P_3_Structure_Activity_Profile">Chiral Regioisomers of INS(1,4,5)P-3 - Structure-Activity Profile</a></div><div class="wp-workCard_item"><span>British Journal of Pharmacology</span><span>, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507429"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507429"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { 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});</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114507429]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507429,"title":"Chiral Regioisomers of INS(1,4,5)P-3 - Structure-Activity Profile","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"British 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class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114507428/Ca2_release_and_binding_studies_of_compounds_structurally_related_to_inositol_1_4_5_trisphosphate_and_adenophostin">Ca2+ release and binding studies of compounds structurally related to inositol 1,4,5-trisphosphate and adenophostin</a></div><div class="wp-workCard_item"><span>British Journal of Pharmacology</span><span>, 1996</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507428"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507428, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114507428]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507428,"title":"Ca2+ release and binding studies of compounds structurally related to inositol 1,4,5-trisphosphate and adenophostin","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1996,"errors":{}},"publication_name":"British Journal of 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class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507426/Developmental_changes_in_intracellular_pH_buffering_power_in_smooth_muscle">Developmental changes in intracellular pH buffering power in smooth muscle</a></div><div class="wp-workCard_item"><span>Pfl�gers Archiv European Journal of Physiology</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2ef188c14a15d48243d28679d851e23b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187954,"asset_id":114507426,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187954/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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})(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2ef188c14a15d48243d28679d851e23b" } } $('.js-work-strip[data-work-id=114507426]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507426,"title":"Developmental changes in intracellular pH buffering power in smooth muscle","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"Intracellular pH (pH i) is known to modulate contraction. Neonatal tissues can differ from adult tissue in contractile response to stimuli known to alter pH i e.g. hypoxia. Changes of pH are attenuated by buffering, thus any difference in buffering power (β) between tissues could affect their functional response to pH i perturbation. Similarly the extent to which any extracellular pH (pH o) alteration is transmitted into a pH i change will also influence function. We have therefore determined the intrinsic β and effect of pH o change on pH i in neonatal and adult ureteric, uterine and gastric smooth muscles using the pH-sensitive fluorophore carboxy-SNARF. β was found to be similar in the three adult tissues, but there were significant differences between neonatal tissues. In contrast, we found little difference in the amount of pH i change produced by pH o change between neonatal and adult tissues from the same smooth muscle, but a difference between smooth muscles. These data highlight significant differences between smooth muscles and their developmental state, which may contribute to different degrees of protection when pH is perturbed.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Pfl�gers Archiv European Journal of 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alt="Research paper thumbnail of An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507396/An_alginate_Based_tube_gel_delivering_2_deoxy_D_ribose_for_stimulation_of_wound_healing">An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing</a></div><div class="wp-workCard_item"><span>Journal of Biomaterials Applications</span><span>, Jul 21, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antiba...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2 deoxy-D-ribose (2dDR) delivered from a variety of dressings is capable of promoting wound healing by stimulating angiogenesis. Alginate hydrogels are an ideal vehicle to deliver a bioactive agent capable of promoting wound healing. In this study we developed and evaluated a tube hydrogel capable of delivering 2dDR with the aim of achieving a stable, convenient to administer and biologically effective wound treatment. Further, we included the stabilizer 2-phenoxy ethanol which provided antimicrobial activity. We synthesized hydrogels by the Green method, using simple mixing of sodium alginate, propylene glycol, 2-phenoxy ethanol and 2dDR in water. FTIR (Fourier transformation infrared spectroscopy) analysis confirmed an absence of undesirable chemical changes in the gel components, and SEM images of the freeze-dried gels showed porous structures. When 2dDR alginate gel (2dDR-SA hydrogel) was placed in PBS at 37°C, almost 92% of 2dDR was released within 7 days. When tested on cultured cells, 2dDR-SA hydrogels did not inhibit metabolic activity or proliferation, achieving up to 90 and 98% of control respectively over 7 days. 2dDR-SA hydrogel also showed anti-bacterial activity against E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA which was attributable to the stabilizer 2-phenoxy ethanol in the hydrogel. Stimulation of angiogenesis in the chorioallantoic membrane assay by 2dDR-SA hydrogel was found to be significant compared to the blank-SA. Wound healing potential was studied in full-thickness wounds in rats where acceleration of wound healing was seen. H&amp;amp;E staining of the wound tissue showed an enhanced number of blood vessels and re-epithelization, and a reduced number of inflammatory cells in 2dDR-SA treated animals compared to blank-hydrogels while Masson’s trichrome staining showed increased collagen deposition. In summary we describe a convenient to apply hydrogel which has promise for use in a range of superficial skin wounds including applications in chronic wound care.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507396"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507396"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507396; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114507396]").text(description); $(".js-view-count[data-work-id=114507396]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114507396; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114507396']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507396, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114507396]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507396,"title":"An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing","translated_title":"","metadata":{"abstract":"Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2 deoxy-D-ribose (2dDR) delivered from a variety of dressings is capable of promoting wound healing by stimulating angiogenesis. Alginate hydrogels are an ideal vehicle to deliver a bioactive agent capable of promoting wound healing. In this study we developed and evaluated a tube hydrogel capable of delivering 2dDR with the aim of achieving a stable, convenient to administer and biologically effective wound treatment. Further, we included the stabilizer 2-phenoxy ethanol which provided antimicrobial activity. We synthesized hydrogels by the Green method, using simple mixing of sodium alginate, propylene glycol, 2-phenoxy ethanol and 2dDR in water. FTIR (Fourier transformation infrared spectroscopy) analysis confirmed an absence of undesirable chemical changes in the gel components, and SEM images of the freeze-dried gels showed porous structures. When 2dDR alginate gel (2dDR-SA hydrogel) was placed in PBS at 37°C, almost 92% of 2dDR was released within 7 days. When tested on cultured cells, 2dDR-SA hydrogels did not inhibit metabolic activity or proliferation, achieving up to 90 and 98% of control respectively over 7 days. 2dDR-SA hydrogel also showed anti-bacterial activity against E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA which was attributable to the stabilizer 2-phenoxy ethanol in the hydrogel. Stimulation of angiogenesis in the chorioallantoic membrane assay by 2dDR-SA hydrogel was found to be significant compared to the blank-SA. Wound healing potential was studied in full-thickness wounds in rats where acceleration of wound healing was seen. H\u0026amp;amp;E staining of the wound tissue showed an enhanced number of blood vessels and re-epithelization, and a reduced number of inflammatory cells in 2dDR-SA treated animals compared to blank-hydrogels while Masson’s trichrome staining showed increased collagen deposition. In summary we describe a convenient to apply hydrogel which has promise for use in a range of superficial skin wounds including applications in chronic wound care.","publisher":"SAGE Publishing","publication_date":{"day":21,"month":7,"year":2023,"errors":{}},"publication_name":"Journal of Biomaterials Applications"},"translated_abstract":"Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2 deoxy-D-ribose (2dDR) delivered from a variety of dressings is capable of promoting wound healing by stimulating angiogenesis. Alginate hydrogels are an ideal vehicle to deliver a bioactive agent capable of promoting wound healing. In this study we developed and evaluated a tube hydrogel capable of delivering 2dDR with the aim of achieving a stable, convenient to administer and biologically effective wound treatment. Further, we included the stabilizer 2-phenoxy ethanol which provided antimicrobial activity. We synthesized hydrogels by the Green method, using simple mixing of sodium alginate, propylene glycol, 2-phenoxy ethanol and 2dDR in water. FTIR (Fourier transformation infrared spectroscopy) analysis confirmed an absence of undesirable chemical changes in the gel components, and SEM images of the freeze-dried gels showed porous structures. When 2dDR alginate gel (2dDR-SA hydrogel) was placed in PBS at 37°C, almost 92% of 2dDR was released within 7 days. When tested on cultured cells, 2dDR-SA hydrogels did not inhibit metabolic activity or proliferation, achieving up to 90 and 98% of control respectively over 7 days. 2dDR-SA hydrogel also showed anti-bacterial activity against E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA which was attributable to the stabilizer 2-phenoxy ethanol in the hydrogel. Stimulation of angiogenesis in the chorioallantoic membrane assay by 2dDR-SA hydrogel was found to be significant compared to the blank-SA. Wound healing potential was studied in full-thickness wounds in rats where acceleration of wound healing was seen. H\u0026amp;amp;E staining of the wound tissue showed an enhanced number of blood vessels and re-epithelization, and a reduced number of inflammatory cells in 2dDR-SA treated animals compared to blank-hydrogels while Masson’s trichrome staining showed increased collagen deposition. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507395"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/114507395/Use_of_an_i_in_Vitro_i_Model_of_Tissue_Engineered_Skin_to_Investigate_the_Mechanism_of_Skin_Graft_Contraction"><img alt="Research paper thumbnail of Use of an<i>in Vitro</i>Model of Tissue-Engineered Skin to Investigate the Mechanism of Skin Graft Contraction" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/114507395/Use_of_an_i_in_Vitro_i_Model_of_Tissue_Engineered_Skin_to_Investigate_the_Mechanism_of_Skin_Graft_Contraction">Use of an<i>in Vitro</i>Model of Tissue-Engineered Skin to Investigate the Mechanism of Skin Graft Contraction</a></div><div class="wp-workCard_item"><span>Tissue Engineering</span><span>, Nov 1, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507395"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507395"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507395; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507390/2_deoxy_d_ribose_2dDR_upregulates_vascular_endothelial_growth_factor_VEGF_and_stimulates_angiogenesis"><img alt="Research paper thumbnail of 2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/111187940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507390/2_deoxy_d_ribose_2dDR_upregulates_vascular_endothelial_growth_factor_VEGF_and_stimulates_angiogenesis">2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis</a></div><div class="wp-workCard_item"><span>Microvascular Research</span><span>, Sep 1, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="37c94cb4008efa5db2645758f4cdf3ad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187940,"asset_id":114507390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187940/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507390; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "37c94cb4008efa5db2645758f4cdf3ad" } } $('.js-work-strip[data-work-id=114507390]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507390,"title":"2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis","translated_title":"","metadata":{"publisher":"Elsevier BV","ai_title_tag":"2-deoxy-D-ribose Enhances VEGF and Angiogenesis in Cells","grobid_abstract":"Background: Delayed neovascularisation of tissue-engineered (TE) complex constructs is a major challenge that causes their failure post-implantation. Although significant progress has been made in the field of angiogenesis, ensuring rapid neovascularisation still remains a challenge. The use of pro-angiogenic agents is an effective approach to promote angiogenesis, and vascular endothelial growth factor (VEGF) has been widely studied both at the biological and molecular levels and is recognised as a key stimulator of angiogenesis. However, the exogenous use of VEGF in an uncontrolled manner has been shown to result in leaky, permeable and haemorrhagic vessels. Thus, researchers have been actively seeking alternative agents to upregulate VEGF production rather than exogenous use of VEGF in TE systems. We have previously revealed the potential of 2-deoxy-D-ribose (2dDR) as an alternative pro-angiogenic agent to induce angiogenesis and accelerates wound healing. However, to date, there is not any clear evidence on whether 2dDR influences the angiogenic cascade that involves VEGF. Methods: In this study, we explored the angiogenic properties of 2dDR either by its direct application to human aortic endothelial cells (HAECs) or when released from commercially available alginate dressings and demonstrated that when 2dDR promotes angiogenesis, it also increases the VEGF production of HAECs. Results: The VEGF quantification results suggested that VEGF production by HAECs was increased with 2dDR treatment but not with other sugars, including 2-deoxy-L-ribose (2dLR) and D-glucose (DG). The stability studies demonstrated that approximately 40-50% of the 2dDR had disappeared in the media over 14 days, either in the presence or absence of HAECs, and the reduction was higher when cells were present. The concentration of VEGF in the media also fell after day 4 associated with the reduction in 2dDR. Conclusion: This study suggests that 2dDR (but not other sugars tested in this study) stimulates angiogenesis by increasing the production of VEGF. We conclude 2dDR appears to be a practical and effective indirect route to upregulating VEGF for several days, leading to increased angiogenesis.","publication_date":{"day":1,"month":9,"year":2020,"errors":{}},"publication_name":"Microvascular Research","grobid_abstract_attachment_id":111187940},"translated_abstract":null,"internal_url":"https://www.academia.edu/114507390/2_deoxy_d_ribose_2dDR_upregulates_vascular_endothelial_growth_factor_VEGF_and_stimulates_angiogenesis","translated_internal_url":"","created_at":"2024-02-05T06:50:26.292-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33365251,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111187940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111187940/thumbnails/1.jpg","file_name":"1-s2.0-S0026286220300959-main-1.pdf","download_url":"https://www.academia.edu/attachments/111187940/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"2_deoxy_d_ribose_2dDR_upregulates_vascul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111187940/1-s2.0-S0026286220300959-main-1-libre.pdf?1707144908=\u0026response-content-disposition=attachment%3B+filename%3D2_deoxy_d_ribose_2dDR_upregulates_vascul.pdf\u0026Expires=1733023476\u0026Signature=GvyuM~JibpWPxnFl1A-V8leDBOb9ZAW7ZGnXKR8suZosHDwnH6B9cqun-lPKV73-aOPQyq7IV5gXz5shyG0t1O-r18gsglU~40ZXElymS5vgu8sooe-iobYexsYrLCDbdppwKQCJt1Fuy7E0MKFLEZ3vYyyh2eoNxM4v8csrt7O9VkA-xy3SPMfJsYY1bCJFA~lvJmVFBoP7rfxaeh1-t2MYwjf0GdhPb1XM33V8eBi0kTXLbKz91r0JQI2kXafkfZn8CWQu8h3cwXhjoxMxrgGUPhkRoS59OeRlOYKAYj7gfecJNxopXi4SRem14aMVuljHtT6VlMQ3i5I0hiA4Jg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"2_deoxy_d_ribose_2dDR_upregulates_vascular_endothelial_growth_factor_VEGF_and_stimulates_angiogenesis","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":33365251,"first_name":"Anthony","middle_initials":null,"last_name":"Bullock","page_name":"AnthonyBullock","domain_name":"sheffield","created_at":"2015-07-27T01:02:57.251-07:00","display_name":"Anthony Bullock","url":"https://sheffield.academia.edu/AnthonyBullock"},"attachments":[{"id":111187940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111187940/thumbnails/1.jpg","file_name":"1-s2.0-S0026286220300959-main-1.pdf","download_url":"https://www.academia.edu/attachments/111187940/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"2_deoxy_d_ribose_2dDR_upregulates_vascul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111187940/1-s2.0-S0026286220300959-main-1-libre.pdf?1707144908=\u0026response-content-disposition=attachment%3B+filename%3D2_deoxy_d_ribose_2dDR_upregulates_vascul.pdf\u0026Expires=1733023476\u0026Signature=GvyuM~JibpWPxnFl1A-V8leDBOb9ZAW7ZGnXKR8suZosHDwnH6B9cqun-lPKV73-aOPQyq7IV5gXz5shyG0t1O-r18gsglU~40ZXElymS5vgu8sooe-iobYexsYrLCDbdppwKQCJt1Fuy7E0MKFLEZ3vYyyh2eoNxM4v8csrt7O9VkA-xy3SPMfJsYY1bCJFA~lvJmVFBoP7rfxaeh1-t2MYwjf0GdhPb1XM33V8eBi0kTXLbKz91r0JQI2kXafkfZn8CWQu8h3cwXhjoxMxrgGUPhkRoS59OeRlOYKAYj7gfecJNxopXi4SRem14aMVuljHtT6VlMQ3i5I0hiA4Jg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":32723,"name":"Angiogenesis","url":"https://www.academia.edu/Documents/in/Angiogenesis"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1796877,"name":"Vascular Endothelial Growth Factor","url":"https://www.academia.edu/Documents/in/Vascular_Endothelial_Growth_Factor"},{"id":3996827,"name":"Microvascular","url":"https://www.academia.edu/Documents/in/Microvascular"}],"urls":[{"id":39207788,"url":"https://doi.org/10.1016/j.mvr.2020.104035"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507388/Characterisation_of_structural_changes_in_collagen_with_Raman_spectroscopy"><img alt="Research paper thumbnail of Characterisation of structural changes in collagen with Raman spectroscopy" class="work-thumbnail" src="https://attachments.academia-assets.com/111187942/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507388/Characterisation_of_structural_changes_in_collagen_with_Raman_spectroscopy">Characterisation of structural changes in collagen with Raman spectroscopy</a></div><div class="wp-workCard_item"><span>Applied Spectroscopy Reviews</span><span>, Jan 9, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1af06183880aeb6b8e0e4740f7b7378e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187942,"asset_id":114507388,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187942/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507388"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507388"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507388; 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More specifically, some progressive diseases are mainly caused by alterations of collagen molecules but what is occurring at the biochemical level of this complex molecule usually remains unclear. While it may be true that a number of analytical techniques can analyze collagen, most of them have a series of limitations that limit their applicability to a wide range of samples. To understand in more detail the progression of a disease due to changes in the collagen structure, a technique that can detect subtle alterations at the biochemical level is needed. Raman spectroscopy is a label-free and noninvasive technique that can easily pick up on any conformational changes reflected primarily at the lipids, amides and proline and hydroxyproline regions. This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understand changes in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.","publication_date":{"day":9,"month":1,"year":2019,"errors":{}},"publication_name":"Applied Spectroscopy Reviews","grobid_abstract_attachment_id":111187942},"translated_abstract":null,"internal_url":"https://www.academia.edu/114507388/Characterisation_of_structural_changes_in_collagen_with_Raman_spectroscopy","translated_internal_url":"","created_at":"2024-02-05T06:50:25.820-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33365251,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111187942,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111187942/thumbnails/1.jpg","file_name":"05704928.2018.150679920240205-1-kquf2k.pdf","download_url":"https://www.academia.edu/attachments/111187942/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterisation_of_structural_changes_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111187942/05704928.2018.150679920240205-1-kquf2k-libre.pdf?1707144916=\u0026response-content-disposition=attachment%3B+filename%3DCharacterisation_of_structural_changes_i.pdf\u0026Expires=1733023476\u0026Signature=NtF9FkeZ0dU-0H6fdWipWMYkdbiZ9kc4~smY4OBiEZlBSHpQ76V4Q62RglqgKtKtB4ItV8Fv1mVrE3VoUygLwtXA40axXvcxIwVfMqeRJJDZB805-kJPf5nl6mbhOKgP3TSYm-H46phrqMEj6oapS9m4ydYaXlH-l8u9FA3EBQO0rvvSB7Y56Vgy161nqG0L3UHJodh9GKvSUZJFoj1qUhHklRbDzyGmUtdIJKTWMODi94bh2tm~YKV-BV5gYDWMnwGCrpHbmVBGiuVUAOWN92c~34SgBh1oIXI4PTuRaJYy4zCuCiJJ1CJK3RxNWaCLHW7rY9V24apolfDM1avP7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Characterisation_of_structural_changes_in_collagen_with_Raman_spectroscopy","translated_slug":"","page_count":35,"language":"en","content_type":"Work","owner":{"id":33365251,"first_name":"Anthony","middle_initials":null,"last_name":"Bullock","page_name":"AnthonyBullock","domain_name":"sheffield","created_at":"2015-07-27T01:02:57.251-07:00","display_name":"Anthony Bullock","url":"https://sheffield.academia.edu/AnthonyBullock"},"attachments":[{"id":111187942,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111187942/thumbnails/1.jpg","file_name":"05704928.2018.150679920240205-1-kquf2k.pdf","download_url":"https://www.academia.edu/attachments/111187942/download_file?st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterisation_of_structural_changes_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111187942/05704928.2018.150679920240205-1-kquf2k-libre.pdf?1707144916=\u0026response-content-disposition=attachment%3B+filename%3DCharacterisation_of_structural_changes_i.pdf\u0026Expires=1733023476\u0026Signature=NtF9FkeZ0dU-0H6fdWipWMYkdbiZ9kc4~smY4OBiEZlBSHpQ76V4Q62RglqgKtKtB4ItV8Fv1mVrE3VoUygLwtXA40axXvcxIwVfMqeRJJDZB805-kJPf5nl6mbhOKgP3TSYm-H46phrqMEj6oapS9m4ydYaXlH-l8u9FA3EBQO0rvvSB7Y56Vgy161nqG0L3UHJodh9GKvSUZJFoj1qUhHklRbDzyGmUtdIJKTWMODi94bh2tm~YKV-BV5gYDWMnwGCrpHbmVBGiuVUAOWN92c~34SgBh1oIXI4PTuRaJYy4zCuCiJJ1CJK3RxNWaCLHW7rY9V24apolfDM1avP7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":502,"name":"Biophysics","url":"https://www.academia.edu/Documents/in/Biophysics"},{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":9339,"name":"Raman Spectroscopy","url":"https://www.academia.edu/Documents/in/Raman_Spectroscopy"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":802828,"name":"Hydroxyproline","url":"https://www.academia.edu/Documents/in/Hydroxyproline"},{"id":1029023,"name":"Molecule","url":"https://www.academia.edu/Documents/in/Molecule"}],"urls":[{"id":39207786,"url":"https://doi.org/10.1080/05704928.2018.1506799"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507387"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507387/KGM_hydrogels_inhibit_the_contraction_of_tissueengineered_skin_and_stimulate_the_proliferation_offibroblasts_in_the_dermal_area"><img alt="Research paper thumbnail of KGM hydrogels inhibit the contraction of tissueengineered skin and stimulate the proliferation offibroblasts in the dermal area" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507387/KGM_hydrogels_inhibit_the_contraction_of_tissueengineered_skin_and_stimulate_the_proliferation_offibroblasts_in_the_dermal_area">KGM hydrogels inhibit the contraction of tissueengineered skin and stimulate the proliferation offibroblasts in the dermal area</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Wound closure skin contraction occurs simultaneously as part of the repairing process to restore ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Wound closure skin contraction occurs simultaneously as part of the repairing process to restore barrier function and protection after an injury. The process of repair without the use of optimized regenerative template from collagen type I, is often accompanied by the formation of scar and skin contraction that cause disfigurement and impaired movements. The work by Yannas et al. elucidated antagonistic relation between wound closure by contraction and regeneration that scar formation is a process secondary to wound contraction which can be prevented simply by early intervention of contraction blocking. A previous study in MacNeil group showed that the contraction of tissue engineered skin based on human dermis appeared to be related to the differentiation status of the keratinocytes. Although Yannas’ work on the cancellation of contraction leading to scarless wound healing was conducted in a well-defined animal model, it was interesting to see the effects of plant heteropolysaccharide, konjac glucomannan (KGM), which is known for its selective effects on the inhibition of keratinocyte proliferation and migration which lead to the inhibition of the contraction of 3D tissue engineered (TE) skin model. This study was aimed to examine the relation between physicochemistry of KGM in soluble and insoluble form; namely interpenetrating network and graft co-network hydrogel on cell viability and phenotype as well as skin contraction and appearance. The biological activities of soluble and insoluble KGM suggest two mechanisms of action in self reorganization and reepithelization of 3D TE skin model: 1) the stimulation of fibroblast proliferation in the dermal area encourages keratinocyte migration for re-epithelisation and 2) the inhibition of keratinocyte proliferation helped to reduce skin contraction that would be beneficial to wound healing.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114507387]").text(description); $(".js-view-count[data-work-id=114507387]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114507387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114507387']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507387, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114507387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507387,"title":"KGM hydrogels inhibit the contraction of tissueengineered skin and stimulate the proliferation offibroblasts in the dermal area","translated_title":"","metadata":{"abstract":"Wound closure skin contraction occurs simultaneously as part of the repairing process to restore barrier function and protection after an injury. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507383"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507383/Developing_an_autologous_tissue_engineered_prosthesis_for_use_in_stress_urinary_incontinence_and_pelvic_organ_prolapse"><img alt="Research paper thumbnail of Developing an autologous tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse" class="work-thumbnail" src="https://attachments.academia-assets.com/111187911/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507383/Developing_an_autologous_tissue_engineered_prosthesis_for_use_in_stress_urinary_incontinence_and_pelvic_organ_prolapse">Developing an autologous tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse</a></div><div class="wp-workCard_item"><span>Neurourology and Urodynamics</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hypothesis / aims of study Our aim is to develop a tissue engineered mesh suitable for use in SUI...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hypothesis / aims of study Our aim is to develop a tissue engineered mesh suitable for use in SUI and POP using a scaffold support and patients’ buccal fibroblasts. In this study we compared four potential scaffolds for their ability to support cell attachment and we examined their mechanical properties both with and without cells and the ability of cells to remodel these scaffolds by producing collagen. The scaffolds were cadaveric dermis (CD), polypropylene (PPL), porcine small intestinal submucosa (SIS) and thermoannealed poly(L)-lactic acid (Th PLA).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="90ca1997afa40dddb07db41042c06d56" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187911,"asset_id":114507383,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187911/download_file?st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507383"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507383"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507383; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114507383]").text(description); $(".js-view-count[data-work-id=114507383]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114507383; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114507383']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507383, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "90ca1997afa40dddb07db41042c06d56" } } $('.js-work-strip[data-work-id=114507383]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507383,"title":"Developing an autologous tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse","translated_title":"","metadata":{"abstract":"Hypothesis / aims of study Our aim is to develop a tissue engineered mesh suitable for use in SUI and POP using a scaffold support and patients’ buccal fibroblasts. 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alt="Research paper thumbnail of An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507396/An_alginate_Based_tube_gel_delivering_2_deoxy_D_ribose_for_stimulation_of_wound_healing">An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing</a></div><div class="wp-workCard_item"><span>Journal of Biomaterials Applications</span><span>, Jul 21, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antiba...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2 deoxy-D-ribose (2dDR) delivered from a variety of dressings is capable of promoting wound healing by stimulating angiogenesis. Alginate hydrogels are an ideal vehicle to deliver a bioactive agent capable of promoting wound healing. In this study we developed and evaluated a tube hydrogel capable of delivering 2dDR with the aim of achieving a stable, convenient to administer and biologically effective wound treatment. Further, we included the stabilizer 2-phenoxy ethanol which provided antimicrobial activity. We synthesized hydrogels by the Green method, using simple mixing of sodium alginate, propylene glycol, 2-phenoxy ethanol and 2dDR in water. FTIR (Fourier transformation infrared spectroscopy) analysis confirmed an absence of undesirable chemical changes in the gel components, and SEM images of the freeze-dried gels showed porous structures. When 2dDR alginate gel (2dDR-SA hydrogel) was placed in PBS at 37°C, almost 92% of 2dDR was released within 7 days. When tested on cultured cells, 2dDR-SA hydrogels did not inhibit metabolic activity or proliferation, achieving up to 90 and 98% of control respectively over 7 days. 2dDR-SA hydrogel also showed anti-bacterial activity against E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA which was attributable to the stabilizer 2-phenoxy ethanol in the hydrogel. Stimulation of angiogenesis in the chorioallantoic membrane assay by 2dDR-SA hydrogel was found to be significant compared to the blank-SA. Wound healing potential was studied in full-thickness wounds in rats where acceleration of wound healing was seen. H&amp;amp;E staining of the wound tissue showed an enhanced number of blood vessels and re-epithelization, and a reduced number of inflammatory cells in 2dDR-SA treated animals compared to blank-hydrogels while Masson’s trichrome staining showed increased collagen deposition. In summary we describe a convenient to apply hydrogel which has promise for use in a range of superficial skin wounds including applications in chronic wound care.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507396"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507396"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507396; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114507396]").text(description); $(".js-view-count[data-work-id=114507396]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114507396; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114507396']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507396, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114507396]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507396,"title":"An alginate-Based tube gel delivering 2-deoxy-D-ribose for stimulation of wound healing","translated_title":"","metadata":{"abstract":"Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2 deoxy-D-ribose (2dDR) delivered from a variety of dressings is capable of promoting wound healing by stimulating angiogenesis. Alginate hydrogels are an ideal vehicle to deliver a bioactive agent capable of promoting wound healing. In this study we developed and evaluated a tube hydrogel capable of delivering 2dDR with the aim of achieving a stable, convenient to administer and biologically effective wound treatment. Further, we included the stabilizer 2-phenoxy ethanol which provided antimicrobial activity. We synthesized hydrogels by the Green method, using simple mixing of sodium alginate, propylene glycol, 2-phenoxy ethanol and 2dDR in water. FTIR (Fourier transformation infrared spectroscopy) analysis confirmed an absence of undesirable chemical changes in the gel components, and SEM images of the freeze-dried gels showed porous structures. When 2dDR alginate gel (2dDR-SA hydrogel) was placed in PBS at 37°C, almost 92% of 2dDR was released within 7 days. When tested on cultured cells, 2dDR-SA hydrogels did not inhibit metabolic activity or proliferation, achieving up to 90 and 98% of control respectively over 7 days. 2dDR-SA hydrogel also showed anti-bacterial activity against E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA which was attributable to the stabilizer 2-phenoxy ethanol in the hydrogel. Stimulation of angiogenesis in the chorioallantoic membrane assay by 2dDR-SA hydrogel was found to be significant compared to the blank-SA. Wound healing potential was studied in full-thickness wounds in rats where acceleration of wound healing was seen. H\u0026amp;amp;E staining of the wound tissue showed an enhanced number of blood vessels and re-epithelization, and a reduced number of inflammatory cells in 2dDR-SA treated animals compared to blank-hydrogels while Masson’s trichrome staining showed increased collagen deposition. In summary we describe a convenient to apply hydrogel which has promise for use in a range of superficial skin wounds including applications in chronic wound care.","publisher":"SAGE Publishing","publication_date":{"day":21,"month":7,"year":2023,"errors":{}},"publication_name":"Journal of Biomaterials Applications"},"translated_abstract":"Developing multifunctional wound dressings capable of inducing rapid angiogenesis and with antibacterial activity would be attractive for diabetic and superficial wound healing. Hydrogels delivered from tubes have several desirable features -they are easy to apply, keep the wound moist, reduce the entry of microorganisms and avoid the need for painful dressing removal. Previously we reported that 2 deoxy-D-ribose (2dDR) delivered from a variety of dressings is capable of promoting wound healing by stimulating angiogenesis. Alginate hydrogels are an ideal vehicle to deliver a bioactive agent capable of promoting wound healing. In this study we developed and evaluated a tube hydrogel capable of delivering 2dDR with the aim of achieving a stable, convenient to administer and biologically effective wound treatment. Further, we included the stabilizer 2-phenoxy ethanol which provided antimicrobial activity. We synthesized hydrogels by the Green method, using simple mixing of sodium alginate, propylene glycol, 2-phenoxy ethanol and 2dDR in water. FTIR (Fourier transformation infrared spectroscopy) analysis confirmed an absence of undesirable chemical changes in the gel components, and SEM images of the freeze-dried gels showed porous structures. When 2dDR alginate gel (2dDR-SA hydrogel) was placed in PBS at 37°C, almost 92% of 2dDR was released within 7 days. When tested on cultured cells, 2dDR-SA hydrogels did not inhibit metabolic activity or proliferation, achieving up to 90 and 98% of control respectively over 7 days. 2dDR-SA hydrogel also showed anti-bacterial activity against E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and MRSA which was attributable to the stabilizer 2-phenoxy ethanol in the hydrogel. Stimulation of angiogenesis in the chorioallantoic membrane assay by 2dDR-SA hydrogel was found to be significant compared to the blank-SA. Wound healing potential was studied in full-thickness wounds in rats where acceleration of wound healing was seen. H\u0026amp;amp;E staining of the wound tissue showed an enhanced number of blood vessels and re-epithelization, and a reduced number of inflammatory cells in 2dDR-SA treated animals compared to blank-hydrogels while Masson’s trichrome staining showed increased collagen deposition. In summary we describe a convenient to apply hydrogel which has promise for use in a range of superficial skin wounds including applications in chronic wound care.","internal_url":"https://www.academia.edu/114507396/An_alginate_Based_tube_gel_delivering_2_deoxy_D_ribose_for_stimulation_of_wound_healing","translated_internal_url":"","created_at":"2024-02-05T06:50:28.339-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33365251,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"An_alginate_Based_tube_gel_delivering_2_deoxy_D_ribose_for_stimulation_of_wound_healing","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33365251,"first_name":"Anthony","middle_initials":null,"last_name":"Bullock","page_name":"AnthonyBullock","domain_name":"sheffield","created_at":"2015-07-27T01:02:57.251-07:00","display_name":"Anthony Bullock","url":"https://sheffield.academia.edu/AnthonyBullock"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing"},{"id":116078,"name":"Staphylococcus aureus","url":"https://www.academia.edu/Documents/in/Staphylococcus_aureus"}],"urls":[{"id":39207793,"url":"https://doi.org/10.1177/08853282231191218"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507390/2_deoxy_d_ribose_2dDR_upregulates_vascular_endothelial_growth_factor_VEGF_and_stimulates_angiogenesis"><img alt="Research paper thumbnail of 2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/111187940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507390/2_deoxy_d_ribose_2dDR_upregulates_vascular_endothelial_growth_factor_VEGF_and_stimulates_angiogenesis">2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis</a></div><div class="wp-workCard_item"><span>Microvascular Research</span><span>, Sep 1, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="37c94cb4008efa5db2645758f4cdf3ad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187940,"asset_id":114507390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187940/download_file?st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507390; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "37c94cb4008efa5db2645758f4cdf3ad" } } $('.js-work-strip[data-work-id=114507390]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507390,"title":"2-deoxy-d-ribose (2dDR) upregulates vascular endothelial growth factor (VEGF) and stimulates angiogenesis","translated_title":"","metadata":{"publisher":"Elsevier BV","ai_title_tag":"2-deoxy-D-ribose Enhances VEGF and Angiogenesis in Cells","grobid_abstract":"Background: Delayed neovascularisation of tissue-engineered (TE) complex constructs is a major challenge that causes their failure post-implantation. Although significant progress has been made in the field of angiogenesis, ensuring rapid neovascularisation still remains a challenge. The use of pro-angiogenic agents is an effective approach to promote angiogenesis, and vascular endothelial growth factor (VEGF) has been widely studied both at the biological and molecular levels and is recognised as a key stimulator of angiogenesis. However, the exogenous use of VEGF in an uncontrolled manner has been shown to result in leaky, permeable and haemorrhagic vessels. Thus, researchers have been actively seeking alternative agents to upregulate VEGF production rather than exogenous use of VEGF in TE systems. We have previously revealed the potential of 2-deoxy-D-ribose (2dDR) as an alternative pro-angiogenic agent to induce angiogenesis and accelerates wound healing. However, to date, there is not any clear evidence on whether 2dDR influences the angiogenic cascade that involves VEGF. Methods: In this study, we explored the angiogenic properties of 2dDR either by its direct application to human aortic endothelial cells (HAECs) or when released from commercially available alginate dressings and demonstrated that when 2dDR promotes angiogenesis, it also increases the VEGF production of HAECs. Results: The VEGF quantification results suggested that VEGF production by HAECs was increased with 2dDR treatment but not with other sugars, including 2-deoxy-L-ribose (2dLR) and D-glucose (DG). The stability studies demonstrated that approximately 40-50% of the 2dDR had disappeared in the media over 14 days, either in the presence or absence of HAECs, and the reduction was higher when cells were present. The concentration of VEGF in the media also fell after day 4 associated with the reduction in 2dDR. Conclusion: This study suggests that 2dDR (but not other sugars tested in this study) stimulates angiogenesis by increasing the production of VEGF. 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More specifically, some progressive diseases are mainly caused by alterations of collagen molecules but what is occurring at the biochemical level of this complex molecule usually remains unclear. While it may be true that a number of analytical techniques can analyze collagen, most of them have a series of limitations that limit their applicability to a wide range of samples. To understand in more detail the progression of a disease due to changes in the collagen structure, a technique that can detect subtle alterations at the biochemical level is needed. Raman spectroscopy is a label-free and noninvasive technique that can easily pick up on any conformational changes reflected primarily at the lipids, amides and proline and hydroxyproline regions. This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understand changes in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.","publication_date":{"day":9,"month":1,"year":2019,"errors":{}},"publication_name":"Applied Spectroscopy Reviews","grobid_abstract_attachment_id":111187942},"translated_abstract":null,"internal_url":"https://www.academia.edu/114507388/Characterisation_of_structural_changes_in_collagen_with_Raman_spectroscopy","translated_internal_url":"","created_at":"2024-02-05T06:50:25.820-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33365251,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111187942,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111187942/thumbnails/1.jpg","file_name":"05704928.2018.150679920240205-1-kquf2k.pdf","download_url":"https://www.academia.edu/attachments/111187942/download_file?st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterisation_of_structural_changes_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111187942/05704928.2018.150679920240205-1-kquf2k-libre.pdf?1707144916=\u0026response-content-disposition=attachment%3B+filename%3DCharacterisation_of_structural_changes_i.pdf\u0026Expires=1733023476\u0026Signature=NtF9FkeZ0dU-0H6fdWipWMYkdbiZ9kc4~smY4OBiEZlBSHpQ76V4Q62RglqgKtKtB4ItV8Fv1mVrE3VoUygLwtXA40axXvcxIwVfMqeRJJDZB805-kJPf5nl6mbhOKgP3TSYm-H46phrqMEj6oapS9m4ydYaXlH-l8u9FA3EBQO0rvvSB7Y56Vgy161nqG0L3UHJodh9GKvSUZJFoj1qUhHklRbDzyGmUtdIJKTWMODi94bh2tm~YKV-BV5gYDWMnwGCrpHbmVBGiuVUAOWN92c~34SgBh1oIXI4PTuRaJYy4zCuCiJJ1CJK3RxNWaCLHW7rY9V24apolfDM1avP7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Characterisation_of_structural_changes_in_collagen_with_Raman_spectroscopy","translated_slug":"","page_count":35,"language":"en","content_type":"Work","owner":{"id":33365251,"first_name":"Anthony","middle_initials":null,"last_name":"Bullock","page_name":"AnthonyBullock","domain_name":"sheffield","created_at":"2015-07-27T01:02:57.251-07:00","display_name":"Anthony Bullock","url":"https://sheffield.academia.edu/AnthonyBullock"},"attachments":[{"id":111187942,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111187942/thumbnails/1.jpg","file_name":"05704928.2018.150679920240205-1-kquf2k.pdf","download_url":"https://www.academia.edu/attachments/111187942/download_file?st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAxOTg3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterisation_of_structural_changes_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111187942/05704928.2018.150679920240205-1-kquf2k-libre.pdf?1707144916=\u0026response-content-disposition=attachment%3B+filename%3DCharacterisation_of_structural_changes_i.pdf\u0026Expires=1733023476\u0026Signature=NtF9FkeZ0dU-0H6fdWipWMYkdbiZ9kc4~smY4OBiEZlBSHpQ76V4Q62RglqgKtKtB4ItV8Fv1mVrE3VoUygLwtXA40axXvcxIwVfMqeRJJDZB805-kJPf5nl6mbhOKgP3TSYm-H46phrqMEj6oapS9m4ydYaXlH-l8u9FA3EBQO0rvvSB7Y56Vgy161nqG0L3UHJodh9GKvSUZJFoj1qUhHklRbDzyGmUtdIJKTWMODi94bh2tm~YKV-BV5gYDWMnwGCrpHbmVBGiuVUAOWN92c~34SgBh1oIXI4PTuRaJYy4zCuCiJJ1CJK3RxNWaCLHW7rY9V24apolfDM1avP7w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":502,"name":"Biophysics","url":"https://www.academia.edu/Documents/in/Biophysics"},{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":9339,"name":"Raman Spectroscopy","url":"https://www.academia.edu/Documents/in/Raman_Spectroscopy"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":802828,"name":"Hydroxyproline","url":"https://www.academia.edu/Documents/in/Hydroxyproline"},{"id":1029023,"name":"Molecule","url":"https://www.academia.edu/Documents/in/Molecule"}],"urls":[{"id":39207786,"url":"https://doi.org/10.1080/05704928.2018.1506799"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507387"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507387/KGM_hydrogels_inhibit_the_contraction_of_tissueengineered_skin_and_stimulate_the_proliferation_offibroblasts_in_the_dermal_area"><img alt="Research paper thumbnail of KGM hydrogels inhibit the contraction of tissueengineered skin and stimulate the proliferation offibroblasts in the dermal area" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507387/KGM_hydrogels_inhibit_the_contraction_of_tissueengineered_skin_and_stimulate_the_proliferation_offibroblasts_in_the_dermal_area">KGM hydrogels inhibit the contraction of tissueengineered skin and stimulate the proliferation offibroblasts in the dermal area</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Wound closure skin contraction occurs simultaneously as part of the repairing process to restore ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Wound closure skin contraction occurs simultaneously as part of the repairing process to restore barrier function and protection after an injury. The process of repair without the use of optimized regenerative template from collagen type I, is often accompanied by the formation of scar and skin contraction that cause disfigurement and impaired movements. The work by Yannas et al. elucidated antagonistic relation between wound closure by contraction and regeneration that scar formation is a process secondary to wound contraction which can be prevented simply by early intervention of contraction blocking. A previous study in MacNeil group showed that the contraction of tissue engineered skin based on human dermis appeared to be related to the differentiation status of the keratinocytes. Although Yannas’ work on the cancellation of contraction leading to scarless wound healing was conducted in a well-defined animal model, it was interesting to see the effects of plant heteropolysaccharide, konjac glucomannan (KGM), which is known for its selective effects on the inhibition of keratinocyte proliferation and migration which lead to the inhibition of the contraction of 3D tissue engineered (TE) skin model. This study was aimed to examine the relation between physicochemistry of KGM in soluble and insoluble form; namely interpenetrating network and graft co-network hydrogel on cell viability and phenotype as well as skin contraction and appearance. The biological activities of soluble and insoluble KGM suggest two mechanisms of action in self reorganization and reepithelization of 3D TE skin model: 1) the stimulation of fibroblast proliferation in the dermal area encourages keratinocyte migration for re-epithelisation and 2) the inhibition of keratinocyte proliferation helped to reduce skin contraction that would be beneficial to wound healing.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507387"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507387"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507387; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114507387]").text(description); $(".js-view-count[data-work-id=114507387]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114507387; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114507387']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507387, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=114507387]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507387,"title":"KGM hydrogels inhibit the contraction of tissueengineered skin and stimulate the proliferation offibroblasts in the dermal area","translated_title":"","metadata":{"abstract":"Wound closure skin contraction occurs simultaneously as part of the repairing process to restore barrier function and protection after an injury. The process of repair without the use of optimized regenerative template from collagen type I, is often accompanied by the formation of scar and skin contraction that cause disfigurement and impaired movements. The work by Yannas et al. elucidated antagonistic relation between wound closure by contraction and regeneration that scar formation is a process secondary to wound contraction which can be prevented simply by early intervention of contraction blocking. A previous study in MacNeil group showed that the contraction of tissue engineered skin based on human dermis appeared to be related to the differentiation status of the keratinocytes. Although Yannas’ work on the cancellation of contraction leading to scarless wound healing was conducted in a well-defined animal model, it was interesting to see the effects of plant heteropolysaccharide, konjac glucomannan (KGM), which is known for its selective effects on the inhibition of keratinocyte proliferation and migration which lead to the inhibition of the contraction of 3D tissue engineered (TE) skin model. This study was aimed to examine the relation between physicochemistry of KGM in soluble and insoluble form; namely interpenetrating network and graft co-network hydrogel on cell viability and phenotype as well as skin contraction and appearance. The biological activities of soluble and insoluble KGM suggest two mechanisms of action in self reorganization and reepithelization of 3D TE skin model: 1) the stimulation of fibroblast proliferation in the dermal area encourages keratinocyte migration for re-epithelisation and 2) the inhibition of keratinocyte proliferation helped to reduce skin contraction that would be beneficial to wound healing.","publication_date":{"day":27,"month":8,"year":2018,"errors":{}}},"translated_abstract":"Wound closure skin contraction occurs simultaneously as part of the repairing process to restore barrier function and protection after an injury. The process of repair without the use of optimized regenerative template from collagen type I, is often accompanied by the formation of scar and skin contraction that cause disfigurement and impaired movements. The work by Yannas et al. elucidated antagonistic relation between wound closure by contraction and regeneration that scar formation is a process secondary to wound contraction which can be prevented simply by early intervention of contraction blocking. A previous study in MacNeil group showed that the contraction of tissue engineered skin based on human dermis appeared to be related to the differentiation status of the keratinocytes. Although Yannas’ work on the cancellation of contraction leading to scarless wound healing was conducted in a well-defined animal model, it was interesting to see the effects of plant heteropolysaccharide, konjac glucomannan (KGM), which is known for its selective effects on the inhibition of keratinocyte proliferation and migration which lead to the inhibition of the contraction of 3D tissue engineered (TE) skin model. This study was aimed to examine the relation between physicochemistry of KGM in soluble and insoluble form; namely interpenetrating network and graft co-network hydrogel on cell viability and phenotype as well as skin contraction and appearance. The biological activities of soluble and insoluble KGM suggest two mechanisms of action in self reorganization and reepithelization of 3D TE skin model: 1) the stimulation of fibroblast proliferation in the dermal area encourages keratinocyte migration for re-epithelisation and 2) the inhibition of keratinocyte proliferation helped to reduce skin contraction that would be beneficial to wound healing.","internal_url":"https://www.academia.edu/114507387/KGM_hydrogels_inhibit_the_contraction_of_tissueengineered_skin_and_stimulate_the_proliferation_offibroblasts_in_the_dermal_area","translated_internal_url":"","created_at":"2024-02-05T06:50:25.611-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33365251,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"KGM_hydrogels_inhibit_the_contraction_of_tissueengineered_skin_and_stimulate_the_proliferation_offibroblasts_in_the_dermal_area","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33365251,"first_name":"Anthony","middle_initials":null,"last_name":"Bullock","page_name":"AnthonyBullock","domain_name":"sheffield","created_at":"2015-07-27T01:02:57.251-07:00","display_name":"Anthony Bullock","url":"https://sheffield.academia.edu/AnthonyBullock"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":8991,"name":"Wound Healing","url":"https://www.academia.edu/Documents/in/Wound_Healing"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":350937,"name":"Fibroblast","url":"https://www.academia.edu/Documents/in/Fibroblast"},{"id":459613,"name":"Dermis","url":"https://www.academia.edu/Documents/in/Dermis"},{"id":468981,"name":"Keratinocyte","url":"https://www.academia.edu/Documents/in/Keratinocyte"}],"urls":[{"id":39207785,"url":"http://irep.iium.edu.my/70361/"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507383"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507383/Developing_an_autologous_tissue_engineered_prosthesis_for_use_in_stress_urinary_incontinence_and_pelvic_organ_prolapse"><img alt="Research paper thumbnail of Developing an autologous tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse" class="work-thumbnail" src="https://attachments.academia-assets.com/111187911/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507383/Developing_an_autologous_tissue_engineered_prosthesis_for_use_in_stress_urinary_incontinence_and_pelvic_organ_prolapse">Developing an autologous tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse</a></div><div class="wp-workCard_item"><span>Neurourology and Urodynamics</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hypothesis / aims of study Our aim is to develop a tissue engineered mesh suitable for use in SUI...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hypothesis / aims of study Our aim is to develop a tissue engineered mesh suitable for use in SUI and POP using a scaffold support and patients’ buccal fibroblasts. In this study we compared four potential scaffolds for their ability to support cell attachment and we examined their mechanical properties both with and without cells and the ability of cells to remodel these scaffolds by producing collagen. The scaffolds were cadaveric dermis (CD), polypropylene (PPL), porcine small intestinal submucosa (SIS) and thermoannealed poly(L)-lactic acid (Th PLA).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="90ca1997afa40dddb07db41042c06d56" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187911,"asset_id":114507383,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187911/download_file?st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507383"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507383"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507383; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114507383]").text(description); $(".js-view-count[data-work-id=114507383]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114507383; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114507383']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114507383, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "90ca1997afa40dddb07db41042c06d56" } } $('.js-work-strip[data-work-id=114507383]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114507383,"title":"Developing an autologous tissue engineered prosthesis for use in stress urinary incontinence and pelvic organ prolapse","translated_title":"","metadata":{"abstract":"Hypothesis / aims of study Our aim is to develop a tissue engineered mesh suitable for use in SUI and POP using a scaffold support and patients’ buccal fibroblasts. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114507377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114507377/Comparative_investigation_of_seven_candidate_scaffolds_for_the_production_of_an_autologous_tissue_engineered_connective_tissue_for_use_in_stress_urinary_incontinence_and_pelvic_organ_prolapse"><img alt="Research paper thumbnail of Comparative investigation of seven candidate scaffolds for the production of an autologous tissue engineered connective tissue for use in stress urinary incontinence and pelvic organ prolapse" class="work-thumbnail" src="https://attachments.academia-assets.com/111187926/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114507377/Comparative_investigation_of_seven_candidate_scaffolds_for_the_production_of_an_autologous_tissue_engineered_connective_tissue_for_use_in_stress_urinary_incontinence_and_pelvic_organ_prolapse">Comparative investigation of seven candidate scaffolds for the production of an autologous tissue engineered connective tissue for use in stress urinary incontinence and pelvic organ prolapse</a></div><div class="wp-workCard_item"><span>Neurourology and Urodynamics</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="85a4666be82498a2f32bccaeb54fb11b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111187926,"asset_id":114507377,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111187926/download_file?st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAxOTg3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114507377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114507377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114507377; 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