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(Credit: Brown University) Guided by computer simulations, an international team of researchers has developed an adhesive patch that can provide support for damaged heart tissue, potentially reducing the stretching of heart muscle that’s common after a heart attack."> <meta property="og:image" content="http://res.cloudinary.com/tbmg/ar_16:9,c_thumb,g_auto:subject,f_auto,q_auto/c_limit,w_400/v1580624277/sites/mdb/articles/2019/insider/20190424_Medical_Design_Story2.jpg"> <meta property="og:image:secure_url" content="https://res.cloudinary.com/tbmg/ar_16:9,c_thumb,g_auto:subject,f_auto,q_auto/c_limit,w_400/v1580624277/sites/mdb/articles/2019/insider/20190424_Medical_Design_Story2.jpg"> <meta property="og:url" content="https://www.medicaldesignbriefs.com/component/content/article/34325-patch-could-limit-muscle-damage-after-heart-attack"> <meta property="og:title" content="Patch Could Limit Muscle Damage after Heart Attack"> <meta property="og:type" content="article"> <meta property="og:locale" content="en_US"> <meta property="og:updated_time" content="2020-11-12 14:49:16"> <meta property="article:modified_time" content="2020-11-12 14:49:16"> <meta property="article:publisher" content="SAE Media Group"> <meta name="description" content=" Hearts with the computer optimized patch (second column from the left) remodeled less than those with no patch at all (far left column) and hearts patched with suboptimal properties (right columns). (Credit: Brown University) Guided by computer simulations, an international team of researchers has developed an adhesive patch that can provide support for damaged heart tissue, potentially reducing the stretching of heart muscle that’s common after a heart attack."> <title>Patch Could Limit Muscle Damage after Heart Attack - Medical Design Briefs</title> <link href="https://www.medicaldesignbriefs.com/component/content/article/34325-patch-could-limit-muscle-damage-after-heart-attack" rel="canonical"> <style> /*! inlined from /media/plg_content_ntb_tagsbot/css/template.min.css by ntb_minifier */ .ntb_tagsbot .taglist { font-style: italic; margin-top: 10px } .ntb_tagsbot .tagmenus { background: #FFE; border: 1px dashed #DDD; padding: 10px; margin-bottom: 10px } .ntb_tagsbot .clusterlist { font-style: italic; margin-bottom: 10px; } .ntb_cluster_div { display: none; } .tagmenus div:first-of-type { font-style: italic; margin-bottom: 10px; } /* end 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var(--bs-nav-link-padding-x);font-size:var(--bs-nav-link-font-size);font-weight:var(--bs-nav-link-font-weight);color:var(--bs-nav-link-color)}.nav-fill .nav-item{flex:1 1 auto;text-align:center}.nav-fill .nav-item .nav-link{width:100%}.navbar{--bs-navbar-padding-x:0;--bs-navbar-padding-y:0.5rem;--bs-navbar-color:rgba(0, 0, 0, 0.55);--bs-navbar-hover-color:rgba(0, 0, 0, 0.7);--bs-navbar-disabled-color:rgba(0, 0, 0, 0.3);--bs-navbar-active-color:rgba(0, 0, 0, 0.9);--bs-navbar-brand-padding-y:0.25rem;--bs-navbar-brand-margin-end:1rem;--bs-navbar-brand-font-size:1.25rem;--bs-navbar-brand-color:rgba(0, 0, 0, 0.9);--bs-navbar-brand-hover-color:rgba(0, 0, 0, 0.9);--bs-navbar-nav-link-padding-x:0.5rem;--bs-navbar-toggler-padding-y:0.25rem;--bs-navbar-toggler-padding-x:0.75rem;--bs-navbar-toggler-font-size:1.25rem;--bs-navbar-toggler-icon-bg:url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%280, 0, 0, 0.55%29' stroke-linecap='round' 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var(--bs-navbar-padding-x);background-image:var(--bs-gradient)}.navbar>.container,.navbar>.container-fluid{display:flex;flex-wrap:inherit;align-items:center;justify-content:space-between}.navbar-brand{padding-top:var(--bs-navbar-brand-padding-y);padding-bottom:var(--bs-navbar-brand-padding-y);margin-right:var(--bs-navbar-brand-margin-end);font-size:var(--bs-navbar-brand-font-size);color:var(--bs-navbar-brand-color);white-space:nowrap}.navbar-nav{--bs-nav-link-padding-x:0;--bs-nav-link-padding-y:0.7rem;--bs-nav-link-color:var(--bs-navbar-color);--bs-nav-link-hover-color:var(--bs-navbar-hover-color);--bs-nav-link-disabled-color:var(--bs-navbar-disabled-color);display:flex;flex-direction:column;padding-left:0;margin-bottom:0;list-style:none}.navbar-collapse{flex-basis:100%;flex-grow:1;align-items:center}.navbar-toggler{padding:var(--bs-navbar-toggler-padding-y) var(--bs-navbar-toggler-padding-x);font-size:var(--bs-navbar-toggler-font-size);line-height:1;color:var(--bs-navbar-color);background-color:transparent;border:var(--bs-border-width) solid var(--bs-navbar-toggler-border-color);border-radius:var(--bs-navbar-toggler-border-radius)}@media (min-width:576px){.navbar-expand-sm{flex-wrap:nowrap;justify-content:flex-start}.navbar-expand-sm .navbar-nav{flex-direction:row}.navbar-expand-sm .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-sm .navbar-collapse{display:flex!important;flex-basis:auto}.navbar-expand-sm .navbar-toggler{display:none}}body:before{display:none}.navbar-dark{--bs-navbar-color:#324a98;--bs-navbar-hover-color:#4d4d4f;--bs-navbar-disabled-color:rgba(255, 255, 255, 0.25);--bs-navbar-active-color:#324a98;--bs-navbar-brand-color:#324a98;--bs-navbar-brand-hover-color:#324a98;--bs-navbar-toggler-border-color:transparent;--bs-navbar-toggler-icon-bg:none}.card{--bs-card-spacer-y:1rem;--bs-card-spacer-x:1rem;--bs-card-title-spacer-y:0.5rem;--bs-card-border-width:1px;--bs-card-border-color:var(--bs-border-color-translucent);--bs-card-border-radius:0.375rem;--bs-card-inner-border-radius:calc(0.375rem - 1px);--bs-card-cap-padding-y:0.5rem;--bs-card-cap-padding-x:1rem;--bs-card-cap-bg:rgba(0, 0, 0, 0.03);--bs-card-bg:#f8f9fa;--bs-card-img-overlay-padding:1rem;--bs-card-group-margin:0.75rem;position:relative;display:flex;flex-direction:column;min-width:0;height:var(--bs-card-height);word-wrap:break-word;background-color:var(--bs-card-bg);background-clip:border-box;border:var(--bs-card-border-width) solid var(--bs-card-border-color);border-radius:var(--bs-card-border-radius);box-shadow:var(--bs-card-box-shadow)}.card-body{flex:1 1 auto;padding:var(--bs-card-spacer-y) var(--bs-card-spacer-x);color:var(--bs-card-color)}.breadcrumb{display:flex;list-style:none;--bs-breadcrumb-padding-x:0;--bs-breadcrumb-padding-y:0.5rem;--bs-breadcrumb-margin-bottom:0;--bs-breadcrumb-font-size:0.75rem;--bs-breadcrumb-bg:transparent;--bs-breadcrumb-divider-color:#6c757d;--bs-breadcrumb-item-padding-x:0.5rem;--bs-breadcrumb-item-active-color:#6c757d;flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "|")}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.alert{--bs-alert-bg:transparent;--bs-alert-padding-x:1rem;--bs-alert-padding-y:1rem;--bs-alert-margin-bottom:1rem;--bs-alert-color:inherit;--bs-alert-border-color:transparent;--bs-alert-border:1px solid var(--bs-alert-border-color);--bs-alert-border-radius:0.375rem;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-primary,.alert-secondary{background-image:var(--bs-gradient)}.alert-primary{--bs-alert-color:rgb(30, 44.4, 91.2);--bs-alert-bg:rgb(214, 218.8, 234.4);--bs-alert-border-color:rgb(193.5, 200.7, 224.1)}.alert-primary .alert-link{color:#182449}.alert-secondary{--bs-alert-color:rgb(64.8, 70.2, 75);--bs-alert-bg:rgb(225.6, 227.4, 229);--bs-alert-border-color:rgb(210.9, 213.6, 216)}.alert-secondary .alert-link{color:#34383c}.alert-native,.alert-success,.alert-validation{--bs-alert-color:rgb(15, 81, 50.4);--bs-alert-bg:rgb(209, 231, 220.8);--bs-alert-border-color:rgb(186, 219, 203.7);background-image:var(--bs-gradient)}.alert-native .alert-link,.alert-success .alert-link,.alert-validation .alert-link{color:#0c4128}.alert-info,.alert-warning{background-image:var(--bs-gradient)}.alert-info{--bs-alert-color:rgb(5.2, 80.8, 96);--bs-alert-bg:rgb(206.6, 244.4, 252);--bs-alert-border-color:rgb(182.4, 239.1, 250.5)}.alert-info .alert-link{color:#04414d}.alert-warning{--bs-alert-color:rgb(102, 77.2, 2.8);--bs-alert-bg:rgb(255, 242.6, 205.4);--bs-alert-border-color:rgb(255, 236.4, 180.6)}.alert-warning .alert-link{color:#523e02}.alert-danger,.alert-error{--bs-alert-color:#8a0000;--bs-alert-bg:#facccc;--bs-alert-border-color:rgb(247.5, 178.5, 178.5);background-image:var(--bs-gradient)}.alert-danger .alert-link,.alert-error .alert-link{color:#6e0000}.alert-light{--bs-alert-color:rgb(99.2, 99.6, 100);--bs-alert-bg:rgb(253.6, 253.8, 254);--bs-alert-border-color:rgb(252.9, 253.2, 253.5);background-image:var(--bs-gradient)}.alert-light .alert-link{color:#4f5050}.alert-cleanup,.alert-dark{--bs-alert-color:rgb(19.8, 22.2, 24.6);--bs-alert-bg:rgb(210.6, 211.4, 212.2);--bs-alert-border-color:rgb(188.4, 189.6, 190.8);background-image:var(--bs-gradient)}.alert-cleanup .alert-link,.alert-dark .alert-link{color:#101214}.alert-inverse{--bs-alert-color:#666666;--bs-alert-bg:white;--bs-alert-border-color:white}.alert-inverse .alert-link{color:#525252}.alert-inverse,.alert-navbar,.alert-navitem{background-image:var(--bs-gradient)}.alert-navbar{--bs-alert-color:rgb(87.2, 88, 88.8);--bs-alert-bg:rgb(247.6, 248, 248.4);--bs-alert-border-color:rgb(243.9, 244.5, 245.1)}.alert-navbar .alert-link{color:#464647}.alert-navitem{--bs-alert-color:#666666;--bs-alert-bg:white;--bs-alert-border-color:white}.alert-navitem .alert-link{color:#525252}.alert-lightgray{--bs-alert-color:rgb(93.2, 94.4, 95.6);--bs-alert-bg:rgb(250.6, 251.2, 251.8);--bs-alert-border-color:rgb(248.4, 249.3, 250.2)}.alert-lightgray .alert-link{color:#4b4c4c}.alert-color-indigo,.alert-lightgray{background-image:var(--bs-gradient)}.alert-advertising,.alert-color-indigo{--bs-alert-color:rgb(61.2, 9.6, 145.2);--bs-alert-bg:rgb(224.4, 207.2, 252.4);--bs-alert-border-color:rgb(209.1, 183.3, 251.1)}.alert-color-indigo .alert-link{color:#310874}.alert-color-cyan{--bs-alert-color:rgb(5.2, 80.8, 96);--bs-alert-bg:rgb(206.6, 244.4, 252);--bs-alert-border-color:rgb(182.4, 239.1, 250.5);background-image:var(--bs-gradient)}.alert-color-cyan .alert-link{color:#04414d}.alert-color-blue,.alert-criticalcss{--bs-alert-color:rgb(7.8, 66, 151.8);--bs-alert-bg:rgb(206.6, 226, 254.6);--bs-alert-border-color:rgb(182.4, 211.5, 254.4);background-image:var(--bs-gradient)}.alert-color-blue .alert-link,.alert-criticalcss .alert-link{color:#063579}.alert-color-orange{background-image:var(--bs-gradient)}.alert-cache,.alert-color-orange{--bs-alert-color:rgb(151.8, 75.6, 12);--bs-alert-bg:rgb(254.6, 229.2, 208);--bs-alert-border-color:rgb(254.4, 216.3, 184.5)}.alert-color-orange .alert-link{color:#793c0a}.alert-color-red{--bs-alert-color:rgb(132, 31.8, 41.4);--bs-alert-bg:rgb(248, 214.6, 217.8);--bs-alert-border-color:rgb(244.5, 194.4, 199.2);background-image:var(--bs-gradient)}.alert-color-red .alert-link{color:#6a1921}.alert-cdnjs,.alert-color-yellow{--bs-alert-color:rgb(102, 77.2, 2.8);--bs-alert-bg:rgb(255, 242.6, 205.4);--bs-alert-border-color:rgb(255, 236.4, 180.6)}.alert-cdnjs .alert-link,.alert-color-yellow .alert-link{color:#523e02}.alert-cdnjs,.alert-color-teal,.alert-color-yellow{background-image:var(--bs-gradient)}.alert-color-teal,.alert-topic{--bs-alert-color:rgb(19.2, 120.6, 90.6);--bs-alert-bg:rgb(210.4, 244.2, 234.2);--bs-alert-border-color:rgb(188.1, 238.8, 223.8)}.alert-color-teal .alert-link{color:#0f6048}.alert-color-green{--bs-alert-color:rgb(15, 81, 50.4);--bs-alert-bg:rgb(209, 231, 220.8);--bs-alert-border-color:rgb(186, 219, 203.7);background-image:var(--bs-gradient)}.alert-color-green .alert-link{color:#0c4128}.alert-cloudinary,.alert-color-pink{--bs-alert-color:rgb(128.4, 30.6, 79.2);--bs-alert-bg:rgb(246.8, 214.2, 230.4);--bs-alert-border-color:rgb(242.7, 193.8, 218.1);background-image:var(--bs-gradient)}.alert-cloudinary .alert-link,.alert-color-pink .alert-link{color:#67183f}.alert-color-black{--bs-alert-color:black;--bs-alert-bg:#cccccc;--bs-alert-border-color:rgb(178.5, 178.5, 178.5);background-image:var(--bs-gradient)}.alert-color-black .alert-link{color:#000}.alert-color-white{--bs-alert-color:#666666;--bs-alert-bg:white;--bs-alert-border-color:white;background-image:var(--bs-gradient)}.alert-color-white .alert-link{color:#525252}.alert-color-gray{--bs-alert-color:rgb(64.8, 70.2, 75);--bs-alert-bg:rgb(225.6, 227.4, 229);--bs-alert-border-color:rgb(210.9, 213.6, 216);background-image:var(--bs-gradient)}.alert-color-gray .alert-link{color:#34383c}.alert-color-gray-dark{--bs-alert-color:rgb(31.2, 34.8, 38.4);--bs-alert-bg:rgb(214.4, 215.6, 216.8);--bs-alert-border-color:rgb(194.1, 195.9, 197.7);background-image:var(--bs-gradient)}.alert-color-gray-dark .alert-link{color:#191c1f}.alert-cache{--bs-alert-color:rgb(61.2, 9.6, 145.2);--bs-alert-bg:rgb(224.4, 207.2, 252.4);--bs-alert-border-color:rgb(209.1, 183.3, 251.1);background-image:var(--bs-gradient)}.alert-cache .alert-link{color:#310874}.alert-notice{--bs-alert-color:rgb(5.2, 80.8, 96);--bs-alert-bg:rgb(206.6, 244.4, 252);--bs-alert-border-color:rgb(182.4, 239.1, 250.5)}.alert-notice .alert-link{color:#04414d}.alert-advertising,.alert-notice,.alert-topic{background-image:var(--bs-gradient)}.alert-topic{--bs-alert-color:rgb(113.4, 34.2, 10.2);--bs-alert-bg:rgb(241.8, 215.4, 207.4);--bs-alert-border-color:rgb(235.2, 195.6, 183.6)}.alert-topic .alert-link{color:#5b1b08}.alert-advertising{--bs-alert-color:rgb(102, 77.2, 2.8);--bs-alert-bg:rgb(255, 242.6, 205.4);--bs-alert-border-color:rgb(255, 236.4, 180.6)}.alert-advertising .alert-link{color:#523e02}.list-group{--bs-list-group-color:#212529;--bs-list-group-bg:#fff;--bs-list-group-border-color:rgba(0, 0, 0, 0.125);--bs-list-group-border-width:1px;--bs-list-group-border-radius:0.375rem;--bs-list-group-item-padding-x:1rem;--bs-list-group-item-padding-y:0.5rem;--bs-list-group-action-color:#495057;--bs-list-group-action-hover-color:#495057;--bs-list-group-action-hover-bg:#f8f9fa;--bs-list-group-action-active-color:#212529;--bs-list-group-action-active-bg:#e9ecef;--bs-list-group-disabled-color:#6c757d;--bs-list-group-disabled-bg:#fff;--bs-list-group-active-color:#fff;--bs-list-group-active-bg:#bd3911;--bs-list-group-active-border-color:#bd3911;display:flex;flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item+.list-group-item{border-top-width:0}.btn-close{box-sizing:content-box;width:1em;height:1em;padding:.25em;color:#000;background:url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e") center/1em auto no-repeat;border:0;border-radius:.375rem;opacity:.5}.modal{--bs-modal-zindex:1055;--bs-modal-width:500px;--bs-modal-padding:1rem;--bs-modal-margin:0.5rem;--bs-modal-bg:#fff;--bs-modal-border-color:var(--bs-border-color-translucent);--bs-modal-border-width:1px;--bs-modal-border-radius:0.5rem;--bs-modal-box-shadow:0 0.125rem 0.25rem rgba(0, 0, 0, 0.075);--bs-modal-inner-border-radius:calc(0.5rem - 1px);--bs-modal-header-padding-x:1rem;--bs-modal-header-padding-y:1rem;--bs-modal-header-padding:1rem 1rem;--bs-modal-header-border-color:var(--bs-border-color);--bs-modal-header-border-width:1px;--bs-modal-title-line-height:1.5;--bs-modal-footer-gap:0.5rem;--bs-modal-footer-border-color:var(--bs-border-color);--bs-modal-footer-border-width:1px;position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin)}.modal.fade .modal-dialog{transform:translate(0,-50px)}.modal-content{position:relative;display:flex;flex-direction:column;width:100%;color:var(--bs-modal-color);background-color:var(--bs-modal-bg);background-clip:padding-box;border:var(--bs-modal-border-width) solid var(--bs-modal-border-color);border-radius:var(--bs-modal-border-radius);box-shadow:var(--bs-modal-box-shadow);outline:0}.modal-header{display:flex;flex-shrink:0;align-items:center;justify-content:space-between;padding:var(--bs-modal-header-padding);border-bottom:var(--bs-modal-header-border-width) solid var(--bs-modal-header-border-color);border-top-left-radius:var(--bs-modal-inner-border-radius);border-top-right-radius:var(--bs-modal-inner-border-radius)}.modal-title{margin-bottom:0;line-height:var(--bs-modal-title-line-height)}.modal-body{position:relative;flex:1 1 auto;padding:var(--bs-modal-padding)}@media (min-width:576px){.modal{--bs-modal-margin:1.75rem;--bs-modal-box-shadow:0 0.5rem 1rem rgba(0, 0, 0, 0.15)}.modal-dialog{max-width:var(--bs-modal-width);margin-right:auto;margin-left:auto}.modal-sm{--bs-modal-width:300px}}.offcanvas{--bs-offcanvas-zindex:1045;--bs-offcanvas-width:400px;--bs-offcanvas-height:30vh;--bs-offcanvas-padding-x:1rem;--bs-offcanvas-padding-y:1rem;--bs-offcanvas-bg:#fff;--bs-offcanvas-border-width:1px;--bs-offcanvas-border-color:var(--bs-border-color-translucent);--bs-offcanvas-box-shadow:0 0.125rem 0.25rem rgba(0, 0, 0, 0.075);position:fixed;bottom:0;z-index:var(--bs-offcanvas-zindex);display:flex;flex-direction:column;max-width:100%;color:var(--bs-offcanvas-color);visibility:hidden;background-color:var(--bs-offcanvas-bg);background-clip:padding-box;outline:0;box-shadow:var(--bs-offcanvas-box-shadow)}.offcanvas.offcanvas-start{top:0;left:0;width:var(--bs-offcanvas-width);border-right:var(--bs-offcanvas-border-width) solid 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class="item-page" itemscope itemtype="https://schema.org/Article"> <meta itemprop="inLanguage" content="en-GB"/> <div class="row"> <div class="article-title col-12 mb-2"><h6 class="overline"> <time datetime="2019-04-24T05:00:27-04:00" itemprop="dateCreated"> April 24, 2019</time> <span class="mx-2">|</span> <a href="/mdb/topic/materials-manufacturing/materials-adhesives-coatings">Materials</a> <span class="mx-2">|</span> <a href="/mdb/topic/sensors-wearables/wearables">Wearables</a> <span class="mx-2">|</span> <a href="/mdb/topic/electronics-software/software">Software</a> <span class="mx-2">|</span> <a href="/component/ntb_tags/topic/medical/*/mdb/*">Medical</a></h6> <time datetime="2020-11-12T09:49:16-05:00" itemprop="dateModified"> </time> <meta itemprop="keywords" content="Materials,Wearables,Software"><h1 itemprop="headline">Patch Could Limit Muscle Damage after Heart Attack</h1></div></div> <div class="row" itemprop="articleBody"><aside class="article-social text-center col-md-1 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src='data:image/svg+xml;base64,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' data-src='https://res.cloudinary.com/tbmg/c_scale,w_auto,f_auto,q_auto/v1580624277/sites/mdb/articles/2019/insider/20190424_Medical_Design_Story2.jpg' class=' w-100 cld-responsive' alt='' alt="Hearts Patched Image" /> <figcaption>Hearts with the computer optimized patch (second column from the left) remodeled less than those with no patch at all (far left column) and hearts patched with suboptimal properties (right columns). (Credit: Brown University)</figcaption></figure> <p>Guided by computer simulations, an international team of researchers has developed an adhesive patch that can provide support for damaged heart tissue, potentially reducing the stretching of heart muscle that’s common after a heart attack.</p> <p>The patch, made from a water-based hydrogel material, was developed using computer simulations of heart function in order to fine tune the material’s mechanical properties. A study in rats showed that the patch was effective in preventing left ventricle remodeling — a stretching of the heart muscle that’s common after a heart attack and can reduce the function of the heart’s main pumping chamber. The research also showed that the computer-optimized patch outperformed patches whose mechanical properties had been selected on an ad hoc basis.</p><div class="ad-position g-0 row mb-3 "> <div class="col-12 align-content-center mx-auto"> <script tb-donotmove>window.ntb_google_ad_manager_items=window.ntb_google_ad_manager_items||[];ntb_google_ad_manager_items.push({display_sizes:['xs','sm'],slot_ad_unit:'medicaldesignbriefs.com_450x450_300x300',slot_code:'21835072403',slot:'/21835072403/medicaldesignbriefs.com_450x450_300x300',slot_ad_sizes:['fluid',[450,450],[300,300]],div_id:'GAM_pos_22_modid_421',target_pos:'22',size_mapping:[],slot_ad_empty:'default'});</script> <div id='GAM_pos_22_modid_421' class=""></div></div></div><p>To develop those principles, the researchers developed a computer model of a beating heart, which captured the mechanical dynamics of both the heart itself and the patch when fixed to the heart’s exterior. The team developed a hydrogel material made from food-sourced starch that could match the properties from the model. The key to the material is that it’s viscoelastic, meaning it combines fluid and solid properties. It has fluid properties up to a certain amount of stress, at which point it solidifies and becomes stiffer.</p> <p>Biochemical markers showed that the patch reduced cell death, scar tissue accumulation and oxidative stress in tissue damaged by heart attack.</p> <p> <a href="https://www.brown.edu/news/2019-04-17/heartpatch" target="_blank" rel="noopener noreferrer">Source <i class="fad fa-external-link fa-sm"></i></a></p> <hr> <div class="ntb_tagsbot"> <div class="taglist"> <strong class="sans-serif text-small">Topics:</strong><br> <a class="badge bg-primary link-white fw-light sans-serif text-small fst-normal" href="/component/ntb_tags/topic/materials/materials/mdb/*?start=0"> <i class="fa-duotone fa-flask-vial"></i> Materials</a> <a class="badge bg-primary link-white fw-light sans-serif text-small fst-normal" href="/component/ntb_tags/topic/medical/medical/mdb/*?start=0"> <i class="fa-duotone fa-book-medical"></i> Medical</a> <a class="badge bg-primary link-white fw-light sans-serif text-small fst-normal" href="/component/ntb_tags/topic/software/simulation_software/mdb/*?start=0"> <i class="fa-duotone fa-code"></i> Simulation Software</a> <a class="badge bg-primary link-white fw-light sans-serif text-small fst-normal" href="/component/ntb_tags/topic/wearables/smart_patches_bandages/mdb/*?start=0"> <i class="fa-duotone fa-watch-smart"></i> Smart Patches and Bandages</a></div></div> <div class="related-content"> <hr> <h4>More From SAE Media Group</h4> <div class="row row-cols-1 row-cols-lg-2 g-1"> <div class="col "> <div class="card text-dark border-primary border-start-0 border-bottom-0 border-end-0 rounded-0 h-100"> <div class="row g-0"> <div class="col-9 col-lg-8"> <div class="card-body p-1 pb-0"> <h6 class="tb-topic-overline text-muted text-uppercase" style="font-size:0.7rem">Tech Briefs</h6> <div class="w-100"></div> <a class="m-0 fw-lighter text-black related_item_link d-inline-block" 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