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We have made many contributions to network and pathway analysis and interpretation of genomics data to support biological discovery and precision medicine applications. More recently we are developing computational methods and an ecosystem theory of tissue function, based on single-cell genomics data, that considers cell-cell interactions, cell growth, and cell internal mechanisms, such as pathways, reactions, and causal relationships, to help understand development, cancer as well as regenerative wound healing processes. We support this work by developing open-source biological pathway and network databases and visualization and analysis software, like <a class="https" href="https://cytoscape.org/">Cytoscape</a>, <a class="http" href="http://www.pathwaycommons.org/">Pathway Commons</a> and <a class="http" href="http://genemania.org/">GeneMANIA</a>, which we collaboratively develop with others. <span class="anchor" id="line-4"></span><span class="anchor" id="line-5"></span><p class="line867"><a href="/ResearchNonExpert">Non-expert explanation</a><br> <br> <a class="https" href="https://www.youtube.com/watch?v=wJyUtbn0O5Y">Watch the Inner Life of the Cell movie from Harvard</a> <span class="anchor" id="line-6"></span><span class="anchor" id="line-7"></span><p class="line867"><strong>Affiliations:</strong><br> <div dir="ltr" id="Affiliations.content" lang="en"><span class="anchor" id="Affiliations.top"></span> <span class="anchor" id="Affiliations.line-1"></span><span class="anchor" id="Affiliations.line-2"></span><p class="line867"><a class="http" href="http://www.thedonnellycentre.utoronto.ca/">The Donnelly Centre</a><br> <span class="anchor" id="Affiliations.line-3"></span><a class="http" href="http://www.moleculargenetics.utoronto.ca/">Department of Molecular Genetics</a><br> <span class="anchor" id="Affiliations.line-4"></span><a class="https" href="https://web.cs.toronto.edu/">Department of Computer Science</a><br> <span class="anchor" id="Affiliations.line-5"></span><a class="http" href="http://www.lunenfeld.ca/">The Lunenfeld-Tanenbaum Research Institute</a> at <a class="http" href="http://www.mtsinai.on.ca/">Sinai Health System</a><br> <span class="anchor" id="Affiliations.line-6"></span><a class="https" href="https://www.uhn.ca/Research/Research_Institutes/Pages/PM_Cancer_Centre.aspx">Princess Margaret Cancer Centre</a> at <a class="https" href="https://www.uhn.ca/Research">University Health Network</a><br> <span class="anchor" id="Affiliations.line-7"></span><a class="http" href="http://gbb.csb.utoronto.ca/">Collaborative Graduate Program in Genome Biology and Bioinformatics</a><br> <span class="anchor" id="Affiliations.line-8"></span><strong>all associated with the</strong> <a class="http" href="http://www.utoronto.ca/">University of Toronto</a><br> <span class="anchor" id="Affiliations.line-9"></span><a class="https" href="https://cifar.ca/research-programs/the-multiscale-human/">The MacMillan Multiscale Human Program, Canadian Institute for Advanced Research</a> <span class="anchor" id="Affiliations.line-10"></span><span class="anchor" id="Affiliations.bottom"></span></div> <span class="anchor" id="line-8"></span><div><table><tbody><tr> <td style="&quot; vertical-align: top; &quot;"><p class="line891"><strong>Where we are:</strong><br> 160 College Street, Room 602<br> The Donnelly Centre<br> University of Toronto<br> Toronto, Ontario<br> Canada, M5S 3E1<br> <br> <a class="http" href="http://maps.google.com/maps?f=q&hl=en&q=160+College+St,+Toronto+ON&om=1">Map</a> <a class="http" href="http://local.biochemistry.utoronto.ca/stagljar/photos/images/donnelly_front2.jpg">Picture</a> </td> <td style="&quot; vertical-align: top; &quot;"><p class="line891"><strong>Contact:</strong><br> Gary Bader<br> Phone: 416-978-6888<br> gary.bader *a-t* utoronto.ca</td> </tr> </tbody></table></div><span class="anchor" id="line-9"></span><span class="anchor" id="line-10"></span><span class="anchor" id="line-11"></span><p class="line867"><a class="http" href="http://www.plos.org">Support Open Access Publishing</a><br> <span class="anchor" id="line-12"></span><span class="anchor" id="line-13"></span><p class="line867"><a class="http" href="http://bioinformatics.ca"><img alt="http://bioinformatics.ca" class="attachment" src="/Home?action=AttachFile&do=get&target=cbw-horizontal.jpg" title="http://bioinformatics.ca" /></a> <span class="anchor" id="line-14"></span><span class="anchor" id="bottom"></span></div>  <div class="clearfix"></div> </div>   </div>  </div>   <div id="pageinfo-container"> <div class="container"> <p id="pageinfo" class="info" lang="en" dir="ltr">Home (last edited 2023-02-28 15:16:56 by <span title="GaryBader @ server2.baderlab.med.utoronto.ca[192.168.81.22]"><a href="/GaryBader" title="GaryBader @ server2.baderlab.med.utoronto.ca[192.168.81.22]">GaryBader</a></span>)</p> </div> </div>   <div id="footer"> <div class="container text-right text-muted"> <ul id="credits"> <li><a href="http://moinmo.in/" title="This site uses the MoinMoin Wiki software.">MoinMoin Powered</a></li><li><a href="http://moinmo.in/Python" title="MoinMoin is written in Python.">Python Powered</a></li><li><a href="http://moinmo.in/GPL" title="MoinMoin is GPL licensed.">GPL licensed</a></li><li><a href="http://validator.w3.org/check?uri=referer" title="Click here to validate this page.">Valid HTML 4.01</a></li> </ul> <center><a href='http://host-tracker.com/' onMouseOver='this.href='http://host-tracker.com/website-uptime-statistics/474337/lvuc/';'><img width=80 height=15 border=0 alt='website tracker' src='http://ext.host-tracker.com/uptime-img/?s=15&t=474337&m=00.0&p=Total&src=lvuc'></a><noscript><a href='http://host-tracker.com/' >remote server monitor</a></noscript></center><script src='http://www.google-analytics.com/urchin.js' type='text/javascript'></script><script type='text/javascript'> _uacct = 'UA-387720-1';urchinTracker();</script> </div>  </div>     <script src="/moin_static198/memodump/js/jquery.min.js"></script>  <script src="/moin_static198/memodump/js/bootstrap.min.js"></script>  <script src="/moin_static198/memodump/js/toggle.js"></script>  <script> +function ($) { // Toggle minified navbar under mobile landscape view $('.navbar-collapse').on('show.bs.collapse', function () { $('.navbar-mobile-toggle').togglejs('show'); 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