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<!DOCTYPE html> <html lang="en"> <head> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="stylesheet" type="text/css" href="/data/_cache/combined_12ul23rrjldvi4n5wmjhzhy.css"/> <title>Home</title> <meta name="keywords" content="Home, CPClab, HHU" /> <meta name="description" content="Home. This is the homepage of the CPClab of the pharmaceutical chemistry department of the Heinrich-Heine University" /> <meta name="generator" content="Typesetter CMS" /> <link rel="canonical" href="/" /> <!-- IE10 viewport hack for Surface/desktop Windows 8 bug --> <!-- <link href="../../assets/css/ie10-viewport-bug-workaround.css" rel="stylesheet"> --> <!--[if lt IE 9]> <script type="text/javascript" src="/include/thirdparty/js/shiv/html5shiv.js"></script> <script type="text/javascript" src="/include/thirdparty/js/respond.min.js"></script><![endif]--> </head> <body> <nav class="navbar navbar-default navbar-static-top"><!-- navbar-fixed-top gp-fixed-adjust --> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target=".navbar-collapse" aria-expanded="false" aria-controls="navbar"> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> <a href="/index.php/" class="navbar-brand"></a> </div> <div class="collapse navbar-collapse"> <div class="gpArea_TopTwoMenu GPAREA"><ul class="nav navbar-nav navbar-right"><li class="active"><a href="/" title="Home">Home</a></li><li class="dropdown"><a class="dropdown-toggle" data-toggle="dropdown" href="/index.php/Research_Page" title="Research">Research <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/index.php/Overview" title="Overview">Overview</a></li><li><a href="/index.php/I.-Structure%2C-Function%2C-and-Molecular-Recognition" title="I. 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Modulating Biomolecular Interactions</a></li></ul></li><li class="dropdown"><a class="dropdown-toggle" data-toggle="dropdown" href="/index.php/Publications" title="Publications">Publications <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/index.php/Papers-and-Book-Chapters" title="Papers and Book Chapters">Papers and Book Chapters</a></li><li><a href="/index.php/Poster-Presentations" title="Poster Presentations">Poster Presentations</a></li><li><a href="/index.php/Patents" title="Patents">Patents</a></li><li><a href="/index.php/Theses" title="Theses">Theses</a></li><li><a href="/index.php/Oral-Presentations" title="Oral Presentations">Oral Presentations</a></li><li><a href="/index.php/Book-Reviews" title="Book Reviews">Book Reviews</a></li></ul></li><li class="dropdown"><a class="dropdown-toggle" data-toggle="dropdown" href="/index.php/People" title="People">People <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/index.php/Group-Members" title="Group Members">Group Members</a></li><li><a href="/index.php/Alumni" title="Alumni">Alumni</a></li></ul></li><li><a href="/index.php/Software" title="Software">Software</a></li><li><a href="/index.php/Web-Server" title="Web Server">Web Server</a></li><li class="dropdown"><a class="dropdown-toggle" data-toggle="dropdown" href="/index.php/More" title="More">More <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/index.php/Openings" title="Openings">Openings</a></li><li><a href="/index.php/Group-Seminar" title="Group Seminar">Group Seminar</a></li><li><a href="/index.php/Teaching" title="Teaching">Teaching</a></li><li><a href="/index.php/Videos" title="Videos">Videos</a></li><li><a href="/index.php/Contact" title="Contact">Contact</a></li><li><a href="/index.php/Impressum" title="Impressum">Impressum</a></li></ul></li></ul></div> </div><!--/.nav-collapse --> </div> </nav> <div class="container"> <div id="gpx_content" class="filenum-1 gp_page_display cf"><div class="GPAREA filetype-text"><div> <h3>Welcome to the Gohlke Group</h3> <p class="lead" style="text-align: center;">Computational Pharmaceutical Chemistry and Molecular Bioinformatics</p> </div> <div class="gpclear"></div></div><div class="GPAREA filetype-wrapper_section center-fit"><img src="/data/_uploaded/image/frontpage/25_01_etr1.png" width="1518" height="1366" class="GPAREA filetype-image" /><div class="GPAREA filetype-text"><p class="x_MsoNormal" style="text-align: center;"> </p> <p class="x_MsoNormal" style="text-align: center;"><span style="font-size:24px;"><span lang="EN-US" style="font-family: "Calibri", sans-serif, serif, "EmojiFont";">Structural components involved in ethylene signaling in plants and investigated by molecular simulations to gain insights into the underlying molecular mechanisms.</span> </span></p> <div class="gpclear"></div></div><div class="gpclear"></div></div><div class="GPAREA filetype-wrapper_section"><div class="GPAREA filetype-text"><div> <hr /> <p align="center" style="text-align: center;"><span style="font-size:18px;">12/23: The <strong>PHOENIX Pharmazie Wissenschaftspreis 2023</strong> in Pharmaceutical Chemistry </span></p> <p align="center" style="text-align: center;"><span style="font-size:18px;">was awarded for the publication </span></p> <p align="center" style="text-align: center;"><span style="font-size:18px;">Bhatia, S.*, Spanier, L., Bickel, D., Dienstbier, N., Woloschin, V., Vogt, M., Pols, H., Lungerich, B., Reiners, J., Aghaallaei, N., Diedrich, D., Frieg, B, Schliehe-Diecks, J., Bopp, B., Lang, F., Gopalswamy, M., Loschwitz, J., Bajohgli, B., Skokowa, J., Borkhardt, A., Hauer, J., Hansen, F.K., Smits, S.H.J., Jose, J., Gohlke, H.*, Kurz, T.*<br /> <em>Development of a first-in-class small molecule inhibitor of the C-terminal Hsp90 dimerization. </em></span></p> <p align="center" style="text-align: center;"><span style="font-size:18px;"><strong>ACS Cent. Sci.</strong> 2022, 8, 636–655.</span></p> </div> <div class="gpclear"></div></div><div class="GPAREA filetype-text"><div> <hr /> <p align="center" style="text-align: center;"><span style="font-size:18px;">04/24: Five grants for computing time on JUWELS, Juelich Supercomputing Center, have been approved, all for molecular simulations. </span></p> <p align="center" style="text-align: center;"><span style="font-size:18px;">The proposal "Structural dynamics of <em>apo</em>, agonist- and antagonist-bound full-length ETR1" has been awarded the John von Neumann Institute for Computing (NIC) Excellence Award 2023/1. Read more <a href="https://www.john-von-neumann-institut.de/en/research/nic-excellence-projects/2023-1">here</a>.</span></p> </div> <div class="gpclear"></div></div><div class="gpclear"></div></div><div class="GPAREA filetype-wrapper_section"><div class="GPAREA filetype-text"><div align="center"> <hr /> <h6 align="center" style="text-align: center;">Member of / funded by:</h6> <p><a href="http://www.biosc.de/" target="_blank"><img alt="BioSC_logo.gif" src="/data/_uploaded/image/logos/org/BioSC.png" style="margin-left: 5px; margin-right: 5px; height: 90px; width: 125px;" /></a><a href="http://www.uni-duesseldorf.de/iGRAD/" target="_blank"> <img alt="igrad_2.png" src="/data/_uploaded/image/logos/org/igrad.png" style="margin-left: 10px; margin-right: 10px; width: 205px; height: 70px;" /></a><a href="https://www.bmbf.de/bmbf/de/home/home_node.html"> <img alt="" src="/data/_uploaded/image/logos/BMBF_Logo.png" style="width: 153px; height: 90px;" /></a><a href="http://www.grk2158.hhu.de/en.html" target="_blank"><img alt="GRK2158_Logo.png" src="/include/image.php?i=h&w=76&h=60&img=%2Fimage%2Flogos%2Forg%2FGRK2158.png" style="margin-left: 10px; margin-right: 10px; height: 60px; width: 76px;" /><img alt="CodeChi" src="/include/image.php?i=1g&w=120&h=105&img=%2Fimage%2Flogos%2FCodeChi.png" style="width: 120px; height: 105px;" /></a><a href="http://cpclab.uni-duesseldorf.de/EFRE_EU_logo.pdf" target="_blank"> </a></p> <p><a href="/data/_uploaded/file/documents/efre_info.pdf" target="_blank"><img alt="EFRE-Foerderhinwei" src="/data/_uploaded/image/logos/efre.png" style="margin-left: 10px; margin-right: 10px; height: 59px; width: 257px;" /> </a><a href="http://www.sfb1208.hhu.de/en.html" target="_blank"><img alt="Sfb_logo.png" src="/include/image.php?i=f&w=263&h=50&img=%2Fimage%2Flogos%2Forg%2FSFB1208.png" style="margin-left: 10px; margin-right: 10px; height: 50px; width: 263px;" /></a><a href="http://www.uniklinikum-jena.de/dynion/Homepage-font-14-p-1.html"><img alt="GRK2158_dynion.png" src="/include/image.php?i=i&w=117&h=70&img=%2Fimage%2Flogos%2Forg%2Fdynion.png" style="margin-left: 10px; margin-right: 10px; height: 70px; width: 117px;" /><img alt="Volkswagen Stiftung" src="/include/image.php?i=1h&w=140&h=102&img=%2Fimage%2Flogos%2FVW_Stiftung.png" style="width: 140px; height: 102px;" /></a></p> <hr /> <h6 align="center" style="text-align: center;">Holger Gohlke also heads the <a href="https://www.fz-juelich.de/de/ibg/ibg-4">Institute of Bio- and Geosciences (IBG-4: Bioinformatics)</a> and headed the <a href="https://www.fz-juelich.de/de/ias/jsc/aktuelles/meldungen/kurznachrichten/2017/2017-07-nic-rg-cbc">John von Neumann Institute (NIC) Research Group</a></h6> <h6 align="center" style="text-align: center;"><a href="https://www.fz-juelich.de/de/ias/jsc/aktuelles/meldungen/kurznachrichten/2017/2017-07-nic-rg-cbc">"Computational Biophysical Chemistry"</a> at Forschungszentrum J眉lich.</h6> <h6 align="center" style="text-align: center;"><a href="https://www.fz-juelich.de/de/ias/jsc/aktuelles/meldungen/kurznachrichten/2017/2017-07-nic-rg-cbc" target="_blank"><img alt="NIC.png" src="/include/image.php?i=k&w=204&h=80&img=%2Fimage%2Flogos%2Forg%2FNIC.jpg" style="margin-left: 10px; margin-right: 10px; height: 80px; width: 204px;" /></a></h6> </div> <div class="gpclear"></div></div><div class="gpclear"></div></div></div><div id="gpAfterContent"><div class="gpArea_ GPAREA"></div></div> <hr/> <footer><p> <span class="sitemap_link"><a href="/index.php/Site_Map" title="Site Map">Site Map</a></span> <span class="login_link"><a href="/index.php/Admin?file=Home" rel="nofollow" data-cmd="login" title="Login">Login</a></span> <div class="gpArea_Extra_Footer GPAREA"><div class="GPAREA filetype-text"><p style="text-align: center;"><a href="https://cpclab.uni-duesseldorf.de/index.php/Impressum">Impressum </a>- <a href="http://www.uni-duesseldorf.de/home/footer/datenschutz.html">Datenschutzerkl盲rung der Heinrich-Heine-Universit盲t D眉sseldorf</a></p> </div></div> </p></footer> </div> <script type="text/javascript" src="/data/_cache/combined_r5o68nrjldvi537lmjhzhy.js"></script> <script> $(function(){$("video,audio").mediaelementplayer({ startVolume : 0.8, defaultVideoWidth : '512', defaultVideoHeight : '288', audioWidth : '100%', audioHeight : '30', loop : false, enableAutosize : true, alwaysShowControls : false, iPadUseNativeControls : false, iPhoneUseNativeControls : false, AndroidUseNativeControls : false, enableKeyboard : true, pauseOtherPlayers : true, features : ["playpause","progress","duration","tracks","volume","fullscreen"] });}); </script> </body> </html>