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class="js-work-strip profile--work_container" data-work-id="96772761"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772761/Antenatal_thyrotropin_releasing_hormone_TRH_for_fetal_pulmonary_maturation_Two_concurrent_randomised_controlled_trials"><img alt="Research paper thumbnail of Antenatal thyrotropin releasing hormone (TRH) for fetal pulmonary maturation: Two concurrent randomised controlled trials" class="work-thumbnail" src="https://attachments.academia-assets.com/98578277/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772761/Antenatal_thyrotropin_releasing_hormone_TRH_for_fetal_pulmonary_maturation_Two_concurrent_randomised_controlled_trials">Antenatal thyrotropin releasing hormone (TRH) for fetal pulmonary maturation: Two concurrent randomised controlled trials</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e7fa5199abdd3884cc968ce70141047" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578277,"asset_id":96772761,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578277/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772761"><a 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lung disease","url":"https://www.academia.edu/Documents/in/Chronic_lung_disease"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772564"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772564/Maternal_pomegranate_juice_attenuates_maternal_inflammation_induced_fetal_brain_injury_by_inhibition_of_apoptosis_neuronal_nitric_oxide_synthase_and_NF_%CE%BAB_in_a_rat_model"><img alt="Research paper thumbnail of Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model" class="work-thumbnail" src="https://attachments.academia-assets.com/98578140/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772564/Maternal_pomegranate_juice_attenuates_maternal_inflammation_induced_fetal_brain_injury_by_inhibition_of_apoptosis_neuronal_nitric_oxide_synthase_and_NF_%CE%BAB_in_a_rat_model">Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. Pregnant rats (24 total) were randomized for intraperitoneal lipopolysaccharide (100 μg/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5 mL per day), resulting in 4 groups of 6 dams (saline/saline, pomegranate juice/saline, saline/lipopolysaccharide, pomegranate juice/lipopolysaccharide). All dams were sacrificed 4 hours following the injection and maternal blood and fetal brains were collected from the 4 treatment groups. Maternal interleukin-6 serum levels and fetal brain caspase 3 active form, n...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff0a61c50735af6cf8e4ef0c7af569c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578140,"asset_id":96772564,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578140/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772564"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772564"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772564; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772564]").text(description); $(".js-view-count[data-work-id=96772564]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772564; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772564']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772564, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ff0a61c50735af6cf8e4ef0c7af569c5" } } $('.js-work-strip[data-work-id=96772564]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772564,"title":"Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model","translated_title":"","metadata":{"abstract":"Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. Pregnant rats (24 total) were randomized for intraperitoneal lipopolysaccharide (100 μg/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5 mL per day), resulting in 4 groups of 6 dams (saline/saline, pomegranate juice/saline, saline/lipopolysaccharide, pomegranate juice/lipopolysaccharide). All dams were sacrificed 4 hours following the injection and maternal blood and fetal brains were collected from the 4 treatment groups. Maternal interleukin-6 serum levels and fetal brain caspase 3 active form, n...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. Pregnant rats (24 total) were randomized for intraperitoneal lipopolysaccharide (100 μg/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5 mL per day), resulting in 4 groups of 6 dams (saline/saline, pomegranate juice/saline, saline/lipopolysaccharide, pomegranate juice/lipopolysaccharide). All dams were sacrificed 4 hours following the injection and maternal blood and fetal brains were collected from the 4 treatment groups. Maternal interleukin-6 serum levels and fetal brain caspase 3 active form, n...","internal_url":"https://www.academia.edu/96772564/Maternal_pomegranate_juice_attenuates_maternal_inflammation_induced_fetal_brain_injury_by_inhibition_of_apoptosis_neuronal_nitric_oxide_synthase_and_NF_%CE%BAB_in_a_rat_model","translated_internal_url":"","created_at":"2023-02-12T09:38:33.132-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578140,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578140/thumbnails/1.jpg","file_name":"j.ajog.2018.04.04020230212-1-orlg5t.pdf","download_url":"https://www.academia.edu/attachments/98578140/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_pomegranate_juice_attenuates_ma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578140/j.ajog.2018.04.04020230212-1-orlg5t-libre.pdf?1676224571=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_pomegranate_juice_attenuates_ma.pdf\u0026Expires=1733240517\u0026Signature=a6HvTI7b9oWRGOfRd6LbRI0IieKAuqNVC4iwDRvXwfbVptx0s6n5BlJWdWMKml8ZBvQRobLOZwwOgQzuhOkCz1aiXuSgbxboo2DcblSRvtlV-VhxohoCF95ILkHJUJY1YSV7PVQZHSZgjYfZIVjnJ4Tb--zNmTzBkbe-U5gNZTdxXneecTvSNlcCRrD24DbTLWArLNhRVDuU8y9NQUfVhcq99d~WUf9e5GN4XVqxE2dcGulUMlkWxGrI74LaNN34xewlIKeo5ZaTAk441xN0VSpdOyP9EpG9xTI5YozP8U1dKGcmbjssUqzPeOcaW908-wVsIlA1HFn0iVWELNd-Tg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Maternal_pomegranate_juice_attenuates_maternal_inflammation_induced_fetal_brain_injury_by_inhibition_of_apoptosis_neuronal_nitric_oxide_synthase_and_NF_κB_in_a_rat_model","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578140,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578140/thumbnails/1.jpg","file_name":"j.ajog.2018.04.04020230212-1-orlg5t.pdf","download_url":"https://www.academia.edu/attachments/98578140/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_pomegranate_juice_attenuates_ma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578140/j.ajog.2018.04.04020230212-1-orlg5t-libre.pdf?1676224571=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_pomegranate_juice_attenuates_ma.pdf\u0026Expires=1733240517\u0026Signature=a6HvTI7b9oWRGOfRd6LbRI0IieKAuqNVC4iwDRvXwfbVptx0s6n5BlJWdWMKml8ZBvQRobLOZwwOgQzuhOkCz1aiXuSgbxboo2DcblSRvtlV-VhxohoCF95ILkHJUJY1YSV7PVQZHSZgjYfZIVjnJ4Tb--zNmTzBkbe-U5gNZTdxXneecTvSNlcCRrD24DbTLWArLNhRVDuU8y9NQUfVhcq99d~WUf9e5GN4XVqxE2dcGulUMlkWxGrI74LaNN34xewlIKeo5ZaTAk441xN0VSpdOyP9EpG9xTI5YozP8U1dKGcmbjssUqzPeOcaW908-wVsIlA1HFn0iVWELNd-Tg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide"},{"id":382388,"name":"Nitric Oxide Synthase","url":"https://www.academia.edu/Documents/in/Nitric_Oxide_Synthase"},{"id":439784,"name":"Saline","url":"https://www.academia.edu/Documents/in/Saline"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772563/Transfer_of_Inhaled_Cannabis_Into_Human_Breast_Milk"><img alt="Research paper thumbnail of Transfer of Inhaled Cannabis Into Human Breast Milk" class="work-thumbnail" src="https://attachments.academia-assets.com/98578125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772563/Transfer_of_Inhaled_Cannabis_Into_Human_Breast_Milk">Transfer of Inhaled Cannabis Into Human Breast Milk</a></div><div class="wp-workCard_item"><span>Obstetrics and gynecology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast mi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. In this pilot pharmacokinetic study, breast milk samples were collected from mothers who regularly consumed cannabis, were 2-5 months postpartum, and exclusively breastfeeding their infants. Women were anonymously recruited for the study. After discontinuing cannabis for at least 24 hours, they were directed to obtain a baseline breast milk sample, then smoke a preweighed, analyzed, standardized strain of cannabis from one preselected dispensary, and collect breast milk samples at specific time points: 20 minutes and 1, 2, and 4 hours. Quantification of delta-9-tetrahydrocannabinol and its metabolites in these collected breast milk samples was performed by high-performance liquid chromatography tandem mass spectrometry. A total of eight women were enrolled. Most were occasional cannabis smokers...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a0663ce46cd4f19e7fe5c16591e3384" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578125,"asset_id":96772563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578125/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772563; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772563]").text(description); $(".js-view-count[data-work-id=96772563]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772563; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772563']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772563, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a0663ce46cd4f19e7fe5c16591e3384" } } $('.js-work-strip[data-work-id=96772563]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772563,"title":"Transfer of Inhaled Cannabis Into Human Breast Milk","translated_title":"","metadata":{"abstract":"To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. In this pilot pharmacokinetic study, breast milk samples were collected from mothers who regularly consumed cannabis, were 2-5 months postpartum, and exclusively breastfeeding their infants. Women were anonymously recruited for the study. After discontinuing cannabis for at least 24 hours, they were directed to obtain a baseline breast milk sample, then smoke a preweighed, analyzed, standardized strain of cannabis from one preselected dispensary, and collect breast milk samples at specific time points: 20 minutes and 1, 2, and 4 hours. Quantification of delta-9-tetrahydrocannabinol and its metabolites in these collected breast milk samples was performed by high-performance liquid chromatography tandem mass spectrometry. A total of eight women were enrolled. Most were occasional cannabis smokers...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Obstetrics and gynecology"},"translated_abstract":"To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. In this pilot pharmacokinetic study, breast milk samples were collected from mothers who regularly consumed cannabis, were 2-5 months postpartum, and exclusively breastfeeding their infants. Women were anonymously recruited for the study. After discontinuing cannabis for at least 24 hours, they were directed to obtain a baseline breast milk sample, then smoke a preweighed, analyzed, standardized strain of cannabis from one preselected dispensary, and collect breast milk samples at specific time points: 20 minutes and 1, 2, and 4 hours. Quantification of delta-9-tetrahydrocannabinol and its metabolites in these collected breast milk samples was performed by high-performance liquid chromatography tandem mass spectrometry. A total of eight women were enrolled. Most were occasional cannabis smokers...","internal_url":"https://www.academia.edu/96772563/Transfer_of_Inhaled_Cannabis_Into_Human_Breast_Milk","translated_internal_url":"","created_at":"2023-02-12T09:38:33.030-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578125,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578125/thumbnails/1.jpg","file_name":"AOG.000000000000257520230212-1-1jvr6n5.pdf","download_url":"https://www.academia.edu/attachments/98578125/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Transfer_of_Inhaled_Cannabis_Into_Human.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578125/AOG.000000000000257520230212-1-1jvr6n5-libre.pdf?1676224570=\u0026response-content-disposition=attachment%3B+filename%3DTransfer_of_Inhaled_Cannabis_Into_Human.pdf\u0026Expires=1733240517\u0026Signature=VOixiJ-bGsdPF98DguG8HR6XSlqejsK0RU7hk-XA3UEL6B8odlt6kh8ARiMNeXJrMU47B0BUk3jJHXTINCI2U7JVHMCpMmhj7Jm6GvSPwLBGIAYfyuFitCXMLHXaKh48791tONc0qQkUo5DE0P7ngnchBusYzpxhnjErHNt8hXkf-xHYUKsjp2manqB8gu9uCQkFLiDGVqnaqg5EUV9TeBTHTYlpjymQiuwlV21y3O6WXBqTeWTSjW2gi0q1jDWHVol9rVcyPMwr3WpEwQ~vPQbTvugPNEum-kdiJJaPIOFxPCyhHOE8Wya11PrIwjNyZfu1cequ3aIxGk5wSjNFzA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Transfer_of_Inhaled_Cannabis_Into_Human_Breast_Milk","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578125,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578125/thumbnails/1.jpg","file_name":"AOG.000000000000257520230212-1-1jvr6n5.pdf","download_url":"https://www.academia.edu/attachments/98578125/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Transfer_of_Inhaled_Cannabis_Into_Human.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578125/AOG.000000000000257520230212-1-1jvr6n5-libre.pdf?1676224570=\u0026response-content-disposition=attachment%3B+filename%3DTransfer_of_Inhaled_Cannabis_Into_Human.pdf\u0026Expires=1733240517\u0026Signature=VOixiJ-bGsdPF98DguG8HR6XSlqejsK0RU7hk-XA3UEL6B8odlt6kh8ARiMNeXJrMU47B0BUk3jJHXTINCI2U7JVHMCpMmhj7Jm6GvSPwLBGIAYfyuFitCXMLHXaKh48791tONc0qQkUo5DE0P7ngnchBusYzpxhnjErHNt8hXkf-xHYUKsjp2manqB8gu9uCQkFLiDGVqnaqg5EUV9TeBTHTYlpjymQiuwlV21y3O6WXBqTeWTSjW2gi0q1jDWHVol9rVcyPMwr3WpEwQ~vPQbTvugPNEum-kdiJJaPIOFxPCyhHOE8Wya11PrIwjNyZfu1cequ3aIxGk5wSjNFzA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":113441,"name":"Obstetrics Gynecology","url":"https://www.academia.edu/Documents/in/Obstetrics_Gynecology"},{"id":238724,"name":"Cannabis","url":"https://www.academia.edu/Documents/in/Cannabis"},{"id":443582,"name":"Breast milk","url":"https://www.academia.edu/Documents/in/Breast_milk"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772562"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772562/In_vivo_maternal_and_in_vitro_BPA_exposure_effects_on_hypothalamic_neurogenesis_and_appetite_regulators"><img alt="Research paper thumbnail of In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators" class="work-thumbnail" src="https://attachments.academia-assets.com/98578126/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772562/In_vivo_maternal_and_in_vitro_BPA_exposure_effects_on_hypothalamic_neurogenesis_and_appetite_regulators">In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators</a></div><div class="wp-workCard_item"><span>Environmental research</span><span>, Jan 21, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As food intake/appetite is one of the critical elements contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn hypothalamic stem cells which form the arcuate nucleus appetite center. For in vivo studies, female rats received BPA prior to and during pregnancy via drinking water, and newborn offspring primary hypothalamic neuroprogenitor (NPCs) were obtained and cultured. For in vitro BPA exposure, primary hypothalamic NPCs from healthy newborns were utilized. In both cases, we studied the effects of BPA on NPC proliferation and differentiation, including putative signal and appetite factors. Maternal BPA increased hypothalamic NPC proliferation and differentiation in newborns, in conjunction with increased neuroproliferative (Hes1) and proneurogenic (Ngn3) protein expression. With NPC differentiation, BPA exposure increased ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="473fb9d75698acf3461d19437027222a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578126,"asset_id":96772562,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578126/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772562"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772562; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772562]").text(description); $(".js-view-count[data-work-id=96772562]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772562; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772562']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772562, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "473fb9d75698acf3461d19437027222a" } } $('.js-work-strip[data-work-id=96772562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772562,"title":"In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators","translated_title":"","metadata":{"abstract":"In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As food intake/appetite is one of the critical elements contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn hypothalamic stem cells which form the arcuate nucleus appetite center. For in vivo studies, female rats received BPA prior to and during pregnancy via drinking water, and newborn offspring primary hypothalamic neuroprogenitor (NPCs) were obtained and cultured. For in vitro BPA exposure, primary hypothalamic NPCs from healthy newborns were utilized. In both cases, we studied the effects of BPA on NPC proliferation and differentiation, including putative signal and appetite factors. Maternal BPA increased hypothalamic NPC proliferation and differentiation in newborns, in conjunction with increased neuroproliferative (Hes1) and proneurogenic (Ngn3) protein expression. With NPC differentiation, BPA exposure increased ...","publication_date":{"day":21,"month":1,"year":2018,"errors":{}},"publication_name":"Environmental research"},"translated_abstract":"In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As food intake/appetite is one of the critical elements contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn hypothalamic stem cells which form the arcuate nucleus appetite center. For in vivo studies, female rats received BPA prior to and during pregnancy via drinking water, and newborn offspring primary hypothalamic neuroprogenitor (NPCs) were obtained and cultured. For in vitro BPA exposure, primary hypothalamic NPCs from healthy newborns were utilized. In both cases, we studied the effects of BPA on NPC proliferation and differentiation, including putative signal and appetite factors. Maternal BPA increased hypothalamic NPC proliferation and differentiation in newborns, in conjunction with increased neuroproliferative (Hes1) and proneurogenic (Ngn3) protein expression. With NPC differentiation, BPA exposure increased ...","internal_url":"https://www.academia.edu/96772562/In_vivo_maternal_and_in_vitro_BPA_exposure_effects_on_hypothalamic_neurogenesis_and_appetite_regulators","translated_internal_url":"","created_at":"2023-02-12T09:38:32.930-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578126,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578126/thumbnails/1.jpg","file_name":"j.envres.2018.02.01120230212-1-jcm8yk.pdf","download_url":"https://www.academia.edu/attachments/98578126/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"In_vivo_maternal_and_in_vitro_BPA_exposu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578126/j.envres.2018.02.01120230212-1-jcm8yk-libre.pdf?1676224575=\u0026response-content-disposition=attachment%3B+filename%3DIn_vivo_maternal_and_in_vitro_BPA_exposu.pdf\u0026Expires=1733240517\u0026Signature=Yw0MStkH-madAUCGGlVWmAAZpo~LfEKqrrvct8Ek12HbQG0GSusykXYeyFpNWsu0i7J4ULxOmw6NHqJVN9EeHTljQ0w-mkL2lj3Rp1DpV37UlE~jqWbBAjClG1JHEmv-ZUQkdazeNgOVAjkK~DVvyTCXmTCdLQvoHeJZWWflr~Hgvj73W0hJ4yD4IUkEdU3vExU32IMtmgfqMaZBZEoNKDim0oYZPpCioTAxePrBB7~L400p9sbiR~9aFHL0QcIgXKUq7DNZ30ucLw65FfR6udskGxzrdlF8CWIgA9l1GVP5x-6K70GAXvlx0J4hRHUP87JyzNe0A4Yg0ZOJ5ty2sg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"In_vivo_maternal_and_in_vitro_BPA_exposure_effects_on_hypothalamic_neurogenesis_and_appetite_regulators","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578126,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578126/thumbnails/1.jpg","file_name":"j.envres.2018.02.01120230212-1-jcm8yk.pdf","download_url":"https://www.academia.edu/attachments/98578126/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"In_vivo_maternal_and_in_vitro_BPA_exposu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578126/j.envres.2018.02.01120230212-1-jcm8yk-libre.pdf?1676224575=\u0026response-content-disposition=attachment%3B+filename%3DIn_vivo_maternal_and_in_vitro_BPA_exposu.pdf\u0026Expires=1733240517\u0026Signature=Yw0MStkH-madAUCGGlVWmAAZpo~LfEKqrrvct8Ek12HbQG0GSusykXYeyFpNWsu0i7J4ULxOmw6NHqJVN9EeHTljQ0w-mkL2lj3Rp1DpV37UlE~jqWbBAjClG1JHEmv-ZUQkdazeNgOVAjkK~DVvyTCXmTCdLQvoHeJZWWflr~Hgvj73W0hJ4yD4IUkEdU3vExU32IMtmgfqMaZBZEoNKDim0oYZPpCioTAxePrBB7~L400p9sbiR~9aFHL0QcIgXKUq7DNZ30ucLw65FfR6udskGxzrdlF8CWIgA9l1GVP5x-6K70GAXvlx0J4hRHUP87JyzNe0A4Yg0ZOJ5ty2sg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":3777,"name":"Neurogenesis","url":"https://www.academia.edu/Documents/in/Neurogenesis"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":58054,"name":"Environmental Sciences","url":"https://www.academia.edu/Documents/in/Environmental_Sciences"},{"id":60842,"name":"Appetite","url":"https://www.academia.edu/Documents/in/Appetite"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":1133132,"name":"Environmental","url":"https://www.academia.edu/Documents/in/Environmental"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772561/Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_"><img alt="Research paper thumbnail of Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)" class="work-thumbnail" src="https://attachments.academia-assets.com/98578124/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772561/Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_">Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)</a></div><div class="wp-workCard_item"><span>Neuroscience</span><span>, Jan 8, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal infection/inflammation may induce fetal inflammatory responses, which have been associat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal infection/inflammation may induce fetal inflammatory responses, which have been associated with long-term offspring cerebral injury. We previously demonstrated that prophylactic N-Acetyl-Cysteine (NAC), administered prior to and following maternal lipopolysaccharide (LPS), reduced offspring cerebral injury as evident on MRI. In the present study, we used MRI to examine the effect of therapeutic NAC following maternal LPS-induced inflammation on neonatal brain injury. Pregnant Sprague-Dawley dams (n = 6) at day 18 of gestation received either intraperitoneal injection of LPS or saline (Control) at time 0. Animals were randomized to receive intravenous injection (tail vein) of NAC or saline at time +30 min. Pups were delivered spontaneously and allowed to mature until postnatal day 25. Male offspring (6-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion Tensor Imaging (DTI), an advanced MRI technique, was performed and quantitative parameters...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f5d6dc7b174b6ac53b65b74386af0b68" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578124,"asset_id":96772561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578124/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772561]").text(description); $(".js-view-count[data-work-id=96772561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772561, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f5d6dc7b174b6ac53b65b74386af0b68" } } $('.js-work-strip[data-work-id=96772561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772561,"title":"Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)","translated_title":"","metadata":{"abstract":"Maternal infection/inflammation may induce fetal inflammatory responses, which have been associated with long-term offspring cerebral injury. We previously demonstrated that prophylactic N-Acetyl-Cysteine (NAC), administered prior to and following maternal lipopolysaccharide (LPS), reduced offspring cerebral injury as evident on MRI. In the present study, we used MRI to examine the effect of therapeutic NAC following maternal LPS-induced inflammation on neonatal brain injury. Pregnant Sprague-Dawley dams (n = 6) at day 18 of gestation received either intraperitoneal injection of LPS or saline (Control) at time 0. Animals were randomized to receive intravenous injection (tail vein) of NAC or saline at time +30 min. Pups were delivered spontaneously and allowed to mature until postnatal day 25. Male offspring (6-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion Tensor Imaging (DTI), an advanced MRI technique, was performed and quantitative parameters...","publication_date":{"day":8,"month":1,"year":2018,"errors":{}},"publication_name":"Neuroscience"},"translated_abstract":"Maternal infection/inflammation may induce fetal inflammatory responses, which have been associated with long-term offspring cerebral injury. We previously demonstrated that prophylactic N-Acetyl-Cysteine (NAC), administered prior to and following maternal lipopolysaccharide (LPS), reduced offspring cerebral injury as evident on MRI. In the present study, we used MRI to examine the effect of therapeutic NAC following maternal LPS-induced inflammation on neonatal brain injury. Pregnant Sprague-Dawley dams (n = 6) at day 18 of gestation received either intraperitoneal injection of LPS or saline (Control) at time 0. Animals were randomized to receive intravenous injection (tail vein) of NAC or saline at time +30 min. Pups were delivered spontaneously and allowed to mature until postnatal day 25. Male offspring (6-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion Tensor Imaging (DTI), an advanced MRI technique, was performed and quantitative parameters...","internal_url":"https://www.academia.edu/96772561/Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_","translated_internal_url":"","created_at":"2023-02-12T09:38:32.826-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578124,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578124/thumbnails/1.jpg","file_name":"j.neuroscience.2018.01.01320230212-1-pzt0j1.pdf","download_url":"https://www.academia.edu/attachments/98578124/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578124/j.neuroscience.2018.01.01320230212-1-pzt0j1-libre.pdf?1676224573=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf\u0026Expires=1733240517\u0026Signature=S4bLRe8UqoCyzjBigt8995tNbdvaU5OoI3gpohrlsCPJCi8CJXzRLVgtUbUyHCd6zh2TIdzlg4KykInD51rWPLca-HA~Pvhv41JSzT9GT4WHA~d-wSDJhfzzIBCfkvIvq7FyKuTY2weipIVMXPZKEafwoLcOi5FAP-uB92bfb20~6Z~274~qczby4Bk253wvsJqmUy79AGzRe9~~ftjhPyy0CZETyRoSZiFpjw38VlzQEhI~YKRLCC6-vC3CqJC5yw0~HCtHZwhvNGw288YoEtNhaVcqoxmv8ca6P45hDRtYjpsouznBzpoAM9F7C56LD0XELCp8Xm3d~TaoResxtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578124,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578124/thumbnails/1.jpg","file_name":"j.neuroscience.2018.01.01320230212-1-pzt0j1.pdf","download_url":"https://www.academia.edu/attachments/98578124/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578124/j.neuroscience.2018.01.01320230212-1-pzt0j1-libre.pdf?1676224573=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf\u0026Expires=1733240517\u0026Signature=S4bLRe8UqoCyzjBigt8995tNbdvaU5OoI3gpohrlsCPJCi8CJXzRLVgtUbUyHCd6zh2TIdzlg4KykInD51rWPLca-HA~Pvhv41JSzT9GT4WHA~d-wSDJhfzzIBCfkvIvq7FyKuTY2weipIVMXPZKEafwoLcOi5FAP-uB92bfb20~6Z~274~qczby4Bk253wvsJqmUy79AGzRe9~~ftjhPyy0CZETyRoSZiFpjw38VlzQEhI~YKRLCC6-vC3CqJC5yw0~HCtHZwhvNGw288YoEtNhaVcqoxmv8ca6P45hDRtYjpsouznBzpoAM9F7C56LD0XELCp8Xm3d~TaoResxtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":41216,"name":"Diffusion MRI","url":"https://www.academia.edu/Documents/in/Diffusion_MRI"},{"id":362036,"name":"White matter","url":"https://www.academia.edu/Documents/in/White_matter"},{"id":640959,"name":"Chorioamnionitis","url":"https://www.academia.edu/Documents/in/Chorioamnionitis"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772560"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772560/Prolonged_Prenatal_Hypernatremia_Alters_Neuroendocrine_and_Electrolyte_Homeostasis_in_Neonatal_Sheep1"><img alt="Research paper thumbnail of Prolonged Prenatal Hypernatremia Alters Neuroendocrine and Electrolyte Homeostasis in Neonatal Sheep1" class="work-thumbnail" src="https://attachments.academia-assets.com/98578153/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772560/Prolonged_Prenatal_Hypernatremia_Alters_Neuroendocrine_and_Electrolyte_Homeostasis_in_Neonatal_Sheep1">Prolonged Prenatal Hypernatremia Alters Neuroendocrine and Electrolyte Homeostasis in Neonatal Sheep1</a></div><div class="wp-workCard_item"><span>Experimental Biology and Medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Arginine vasopressin (AVP) is a neuroendocrine hormone synthesized in the hypothalamus, and is st...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Arginine vasopressin (AVP) is a neuroendocrine hormone synthesized in the hypothalamus, and is stored and secreted by the posterior pituitary gland in response to stimuli such as plasma hypertonicity and hypotension. The primary physiologic roles of AVP include plasma osmolality and blood pressure regulation. We have previously demonstrated that chronic prenatal plasma hypertonicity alters the AVP regulatory pathway in newborn lambs. The objectives of the present study were to evaluate prolonged effects of antenatal plasma hypertonicity on neonatal plasma osmoregulation. Pregnant ewes at 119 ± 3 days of gestation were water restricted to achieve and maintain hypertonicity until normal-term delivery. After delivery, ewes were provided food and water ad libitum and lambs were allowed maternal nursing. At the age of 28 days, blood samples were obtained for the analysis of plasma osmolality, electrolytes, and AVP levels from study (n = 5) and age-matched control (n = 6) lambs. Subsequen...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fb26d92a6523d201f0fffcef36049f9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578153,"asset_id":96772560,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578153/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772560"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772560"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772560; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772560]").text(description); $(".js-view-count[data-work-id=96772560]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772560; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772560']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772560, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fb26d92a6523d201f0fffcef36049f9f" } } $('.js-work-strip[data-work-id=96772560]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772560,"title":"Prolonged Prenatal Hypernatremia Alters Neuroendocrine and Electrolyte Homeostasis in Neonatal Sheep1","translated_title":"","metadata":{"abstract":"Arginine vasopressin (AVP) is a neuroendocrine hormone synthesized in the hypothalamus, and is stored and secreted by the posterior pituitary gland in response to stimuli such as plasma hypertonicity and hypotension. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772557"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772557/Maternal_bisphenol_A_exposure_alters_rat_offspring_hepatic_and_skeletal_muscle_insulin_signaling_protein_abundance"><img alt="Research paper thumbnail of Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance" class="work-thumbnail" src="https://attachments.academia-assets.com/98578168/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772557/Maternal_bisphenol_A_exposure_alters_rat_offspring_hepatic_and_skeletal_muscle_insulin_signaling_protein_abundance">Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Mar 9, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The obesogenic and diabetogenic effects of the environmental toxin bisphenol A during critical wi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The obesogenic and diabetogenic effects of the environmental toxin bisphenol A during critical windows of development are well recognized. Liver and skeletal muscle play a central role in the control of glucose production, utilization, and storage. We hypothesized that maternal bisphenol A exposure disrupts insulin signaling in rat offspring liver and skeletal muscle. We determined the protein expression of hepatic and skeletal muscle insulin signaling molecules including insulin receptor beta, its downstream target insulin receptor substrate 1 and glucose transporters (glucose transporter 2, glucose transporter 4), and hepatic glucose-regulating enzymes phosphoenolpyruvate carboxykinase and glucokinase. Rat dams had ad libitum access to filtered drinking water (control) or drinking water with bisphenol A from 2 weeks prior to mating and through pregnancy and lactation. Offspring litters were standardized to 4 males and 4 females and nursed by the same dam. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772556"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772556/Acardiac_twin_pregnancies_part_III_Model_simulations"><img alt="Research paper thumbnail of Acardiac twin pregnancies part III: Model simulations" class="work-thumbnail" src="https://attachments.academia-assets.com/98578165/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772556/Acardiac_twin_pregnancies_part_III_Model_simulations">Acardiac twin pregnancies part III: Model simulations</a></div><div class="wp-workCard_item"><span>Birth Defects Research Part A: Clinical and Molecular Teratology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d5070573fef88a676cc8664241acbf81" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578165,"asset_id":96772556,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578165/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772556"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772556"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772556; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772556]").text(description); $(".js-view-count[data-work-id=96772556]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772556; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772556']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772556, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Pump twins therefore must continuously increase their cardiac output which may cause heart failure. Our aims were: to adapt our twin-twin transfusion syndrome model for acardiac twin pregnancies, to simulate pump and acardiac twin development, and to examine the model for early prognostic markers of pump twin survival. Methods: We used an infinite acardiac placental resistance, based on placental dye injection studies and simulations, suggesting the AA-Acardiac-VV series resistance determines the pump twin's excess cardiac output. Pump and acardiac development were expressed by the pump's excess cardiac output versus its normal value, represented by pump/acardiac umbilical venous diameter (UVD) ratios. Results: UVD ratios distinguish between AA-VV anastomoses that do and do not cause hydropic pump twins. Pump twins can handle relative larger acardiac perfusion at later than earlier gestation. Both VV and acardiac resistances are significantly smaller than the AA resistance, based on respectively clinical data and acardiac blood volumetric growth. Conclusion: Our simulations support clinical results which show that UVD ratios aid in the prediction of pump twin risk. The AA anastomosis controls the future of both the pump and the acardiac. Correlation between acardiac size and pump twin risk is secondary to the AA size but remains clinically usable. These factors may aid in the development of methods for pump twin prognosis and the promotion of selective clinical interventions.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","grobid_abstract_attachment_id":98578165},"translated_abstract":null,"internal_url":"https://www.academia.edu/96772556/Acardiac_twin_pregnancies_part_III_Model_simulations","translated_internal_url":"","created_at":"2023-02-12T09:38:32.112-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578165,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578165/thumbnails/1.jpg","file_name":"bdra.2355920230212-1-1jpang0.pdf","download_url":"https://www.academia.edu/attachments/98578165/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acardiac_twin_pregnancies_part_III_Model.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578165/bdra.2355920230212-1-1jpang0-libre.pdf?1676224562=\u0026response-content-disposition=attachment%3B+filename%3DAcardiac_twin_pregnancies_part_III_Model.pdf\u0026Expires=1733240517\u0026Signature=NbWwlt3DG16jgTs3plxVwRI8zNxGYreRVT4P39-vh5YPDd2fYD6M2jRLpELtcOyj2tcJ-4cVQsNjUdARwDri0AHpZMWO9IjSN-5jW6ngqqIhSBVotiKK8sHGx4LLp8-~bl6FfTj6UH1BrJfW2NJugbSgY2ub6P3OaSaZYByYJRtxa17xed6Bm-rt79rqYzXvaL5aDi3a5UceX5Gi~E2MbInvtWtyf1WMHvPosDOibVDz75R3fbVPvunsDTjnB6yX6g1ZU42HKk3DgKdCjBfcabGSzAOU0JrzrcBB-jFgxA3u7I1mI-nhtNKKnXiLYilcuHpQecCy27mBdioL6dVY8A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Acardiac_twin_pregnancies_part_III_Model_simulations","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578165,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578165/thumbnails/1.jpg","file_name":"bdra.2355920230212-1-1jpang0.pdf","download_url":"https://www.academia.edu/attachments/98578165/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acardiac_twin_pregnancies_part_III_Model.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578165/bdra.2355920230212-1-1jpang0-libre.pdf?1676224562=\u0026response-content-disposition=attachment%3B+filename%3DAcardiac_twin_pregnancies_part_III_Model.pdf\u0026Expires=1733240517\u0026Signature=NbWwlt3DG16jgTs3plxVwRI8zNxGYreRVT4P39-vh5YPDd2fYD6M2jRLpELtcOyj2tcJ-4cVQsNjUdARwDri0AHpZMWO9IjSN-5jW6ngqqIhSBVotiKK8sHGx4LLp8-~bl6FfTj6UH1BrJfW2NJugbSgY2ub6P3OaSaZYByYJRtxa17xed6Bm-rt79rqYzXvaL5aDi3a5UceX5Gi~E2MbInvtWtyf1WMHvPosDOibVDz75R3fbVPvunsDTjnB6yX6g1ZU42HKk3DgKdCjBfcabGSzAOU0JrzrcBB-jFgxA3u7I1mI-nhtNKKnXiLYilcuHpQecCy27mBdioL6dVY8A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1083,"name":"Developmental Biology","url":"https://www.academia.edu/Documents/in/Developmental_Biology"},{"id":4258,"name":"Embryology","url":"https://www.academia.edu/Documents/in/Embryology"},{"id":4906,"name":"Teratology","url":"https://www.academia.edu/Documents/in/Teratology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57980,"name":"Congenital Heart Defects","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Defects"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":105510,"name":"Journal Article","url":"https://www.academia.edu/Documents/in/Journal_Article"},{"id":161534,"name":"Perfusion","url":"https://www.academia.edu/Documents/in/Perfusion"},{"id":319045,"name":"Computational Model","url":"https://www.academia.edu/Documents/in/Computational_Model"},{"id":770944,"name":"Fetus","url":"https://www.academia.edu/Documents/in/Fetus"},{"id":1299572,"name":"Anastomosis","url":"https://www.academia.edu/Documents/in/Anastomosis"},{"id":2937977,"name":"Cardiac output","url":"https://www.academia.edu/Documents/in/Cardiac_output"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":28916542,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbdra.23559"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772555"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772555/Fatty_Acid_de_Novo_Synthesis_in_Adult_Intrauterine_Growth_Restricted_Offspring_and_Adult_Male_Response_to_a_High_Fat_Diet"><img alt="Research paper thumbnail of Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet" class="work-thumbnail" src="https://attachments.academia-assets.com/98578147/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772555/Fatty_Acid_de_Novo_Synthesis_in_Adult_Intrauterine_Growth_Restricted_Offspring_and_Adult_Male_Response_to_a_High_Fat_Diet">Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet</a></div><div class="wp-workCard_item"><span>Lipids</span><span>, Jan 22, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insulin resistance. We have previously shown that IUGR male rats demonstrated increased de novo fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, de novo synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid de novo synthesis in IUGR adult males (6 months) using deuterium-enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline de novo synthesis in both SC fat and visceral fat. Correspondingly, SC and visceral fat protein ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cd5e4741f0a289100f624cd8f5354052" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578147,"asset_id":96772555,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578147/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772555"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772555; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772555]").text(description); $(".js-view-count[data-work-id=96772555]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772555; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772555']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772555, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cd5e4741f0a289100f624cd8f5354052" } } $('.js-work-strip[data-work-id=96772555]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772555,"title":"Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet","translated_title":"","metadata":{"abstract":"Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insulin resistance. We have previously shown that IUGR male rats demonstrated increased de novo fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, de novo synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid de novo synthesis in IUGR adult males (6 months) using deuterium-enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline de novo synthesis in both SC fat and visceral fat. Correspondingly, SC and visceral fat protein ...","ai_title_tag":"De Novo Fatty Acid Synthesis in IUGR Adult Male Rats","publication_date":{"day":22,"month":1,"year":2016,"errors":{}},"publication_name":"Lipids"},"translated_abstract":"Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insulin resistance. We have previously shown that IUGR male rats demonstrated increased de novo fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, de novo synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid de novo synthesis in IUGR adult males (6 months) using deuterium-enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline de novo synthesis in both SC fat and visceral fat. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772554"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772554/Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model"><img alt="Research paper thumbnail of Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772554/Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model">Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Sep 24, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal magnesium administration has been shown to protect the preterm fetus from white- and gra...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal magnesium administration has been shown to protect the preterm fetus from white- and gray-matter injury, although the mechanism is unknown. The purpose of the study is to test the following hypotheses: (1) maternal infections/inflammation activate fetal neuronal N-methyl-D-aspartate receptors that up-regulate neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells pathways; and (2) maternal magnesium sulfate attenuates fetal brain neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation through N-methyl-D-aspartate receptors. Pregnant rats at E16 and E18 (n = 6, 48 total) received injections of intraperitoneal lipopolysaccharide 500 μg/kg or saline at time 0. Dams were randomized for treatment with subcutaneous magnesium sulfate (270 mg/kg) or saline for 2 hours prior to and following lipopolysaccharide/saline injections. At 4 hours after lipopolysaccharide administration, fetal br...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772554"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772554"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772554; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772554]").text(description); $(".js-view-count[data-work-id=96772554]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772554; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772554']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772554, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=96772554]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772554,"title":"Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model","translated_title":"","metadata":{"abstract":"Maternal magnesium administration has been shown to protect the preterm fetus from white- and gray-matter injury, although the mechanism is unknown. The purpose of the study is to test the following hypotheses: (1) maternal infections/inflammation activate fetal neuronal N-methyl-D-aspartate receptors that up-regulate neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells pathways; and (2) maternal magnesium sulfate attenuates fetal brain neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation through N-methyl-D-aspartate receptors. Pregnant rats at E16 and E18 (n = 6, 48 total) received injections of intraperitoneal lipopolysaccharide 500 μg/kg or saline at time 0. Dams were randomized for treatment with subcutaneous magnesium sulfate (270 mg/kg) or saline for 2 hours prior to and following lipopolysaccharide/saline injections. At 4 hours after lipopolysaccharide administration, fetal br...","publication_date":{"day":24,"month":9,"year":2016,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Maternal magnesium administration has been shown to protect the preterm fetus from white- and gray-matter injury, although the mechanism is unknown. The purpose of the study is to test the following hypotheses: (1) maternal infections/inflammation activate fetal neuronal N-methyl-D-aspartate receptors that up-regulate neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells pathways; and (2) maternal magnesium sulfate attenuates fetal brain neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation through N-methyl-D-aspartate receptors. Pregnant rats at E16 and E18 (n = 6, 48 total) received injections of intraperitoneal lipopolysaccharide 500 μg/kg or saline at time 0. Dams were randomized for treatment with subcutaneous magnesium sulfate (270 mg/kg) or saline for 2 hours prior to and following lipopolysaccharide/saline injections. At 4 hours after lipopolysaccharide administration, fetal br...","internal_url":"https://www.academia.edu/96772554/Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model","translated_internal_url":"","created_at":"2023-02-12T09:38:31.857-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide"},{"id":123418,"name":"NF-kappa B","url":"https://www.academia.edu/Documents/in/NF-kappa_B"},{"id":235677,"name":"Behavioral Animal Models","url":"https://www.academia.edu/Documents/in/Behavioral_Animal_Models"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":382388,"name":"Nitric Oxide Synthase","url":"https://www.academia.edu/Documents/in/Nitric_Oxide_Synthase"},{"id":1279813,"name":"Magnesium Sulfate","url":"https://www.academia.edu/Documents/in/Magnesium_Sulfate"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772553"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772553/Assessment_of_a_Cervicometer_Compared_to_Transvaginal_Ultrasound_in_Identifying_Women_with_a_Short_Cervical_Length_A_Multicenter_Study"><img alt="Research paper thumbnail of Assessment of a Cervicometer Compared to Transvaginal Ultrasound in Identifying Women with a Short Cervical Length: A Multicenter Study" class="work-thumbnail" src="https://attachments.academia-assets.com/98578162/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772553/Assessment_of_a_Cervicometer_Compared_to_Transvaginal_Ultrasound_in_Identifying_Women_with_a_Short_Cervical_Length_A_Multicenter_Study">Assessment of a Cervicometer Compared to Transvaginal Ultrasound in Identifying Women with a Short Cervical Length: A Multicenter Study</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Jan 17, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical length as measured by transvaginal ultrasound in the second trimester represents the single most predictive risk factor for spontaneous preterm birth. Previous studies have addressed, in part, the limitations of transvaginal ultrasound availability by utilizing a cervicometer to screen patients for short cervix, identifying those patients who may not benefit from transvaginal ultrasound cervical length screening. In view of the prior studies indicating that a cervicometer measurement may have a high negative predictive value for a sonographically short cervix, we sought to identify the ideal cervicometer threshold value in a prospective, multicenter study. The primary objective was to determine the cervicometer cervical length measurement threshold that provides a high negative predictive value for the identification of patients who are highly unlikely to have a transvaginal ultrasound ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b78c4463f6c5baebbba2b4c08ac4e6c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578162,"asset_id":96772553,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578162/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772553"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772553"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772553; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772553]").text(description); $(".js-view-count[data-work-id=96772553]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772553; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772553']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772553, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6b78c4463f6c5baebbba2b4c08ac4e6c" } } $('.js-work-strip[data-work-id=96772553]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772553,"title":"Assessment of a Cervicometer Compared to Transvaginal Ultrasound in Identifying Women with a Short Cervical Length: A Multicenter Study","translated_title":"","metadata":{"abstract":"Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical length as measured by transvaginal ultrasound in the second trimester represents the single most predictive risk factor for spontaneous preterm birth. Previous studies have addressed, in part, the limitations of transvaginal ultrasound availability by utilizing a cervicometer to screen patients for short cervix, identifying those patients who may not benefit from transvaginal ultrasound cervical length screening. In view of the prior studies indicating that a cervicometer measurement may have a high negative predictive value for a sonographically short cervix, we sought to identify the ideal cervicometer threshold value in a prospective, multicenter study. The primary objective was to determine the cervicometer cervical length measurement threshold that provides a high negative predictive value for the identification of patients who are highly unlikely to have a transvaginal ultrasound ...","publication_date":{"day":17,"month":1,"year":2016,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical length as measured by transvaginal ultrasound in the second trimester represents the single most predictive risk factor for spontaneous preterm birth. Previous studies have addressed, in part, the limitations of transvaginal ultrasound availability by utilizing a cervicometer to screen patients for short cervix, identifying those patients who may not benefit from transvaginal ultrasound cervical length screening. In view of the prior studies indicating that a cervicometer measurement may have a high negative predictive value for a sonographically short cervix, we sought to identify the ideal cervicometer threshold value in a prospective, multicenter study. 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href="https://www.academia.edu/96772552/Programmed_Hyperphagia_in_Offspring_of_Obese_Dams_Altered_Expression_of_Hypothalamic_Nutrient_Sensors_Neurogenic_Factors_and_Epigenetic_Modulators"><img alt="Research paper thumbnail of Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators" class="work-thumbnail" src="https://attachments.academia-assets.com/98578174/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772552/Programmed_Hyperphagia_in_Offspring_of_Obese_Dams_Altered_Expression_of_Hypothalamic_Nutrient_Sensors_Neurogenic_Factors_and_Epigenetic_Modulators">Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators</a></div><div class="wp-workCard_item"><span>Appetite</span><span>, Jan 16, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia. This is remarkably similar to the effects of maternal undernutrition on offspring hyperphagia and obesity. In view of the marked differences in the energy environment of the over and under-nutrition exposures, we studied the expression of select epigenetic modifiers associated with energy imbalance including neurogenic factors and appetite/satiety neuropeptides which are indicative of neurogenic differentiation. HF offspring were exposed to maternal overnutrition (high fat diet; HF) during pregnancy and lactation. We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC). Despite maternal obesity, male offspring born to obese dams had similar body weight at bi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2598dc07dacd20c621bcbdccd99cd32e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578174,"asset_id":96772552,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578174/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772552"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772552"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772552; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772552]").text(description); $(".js-view-count[data-work-id=96772552]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772552; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772552']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772552, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2598dc07dacd20c621bcbdccd99cd32e" } } $('.js-work-strip[data-work-id=96772552]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772552,"title":"Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators","translated_title":"","metadata":{"abstract":"Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772550/Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring"><img alt="Research paper thumbnail of Magnesium sulphate prevents maternal inflammation-induced impairment of learning ability and memory in the rat offspring" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772550/Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring">Magnesium sulphate prevents maternal inflammation-induced impairment of learning ability and memory in the rat offspring</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Jan 29, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal chorioamnionitis is associated with newborn neurologic injury. Recent evidence suggests ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal chorioamnionitis is associated with newborn neurologic injury. Recent evidence suggests that maternal administration of magnesium sulphate (MG) may protect fetuses from white matter injury. Previously we demonstrated evidence by magnetic resonance imaging, that MG may prevent maternal inflammation-induced gray matter injury of offspring. Thus, we sought to determine the potential of maternal inflammation to induce fetal neurologic/behavioral deficits, and assess whether maternal MG attenuates these effects. Pregnant rats at day 18 received injections of intraperitoneal lipopolysaccharide (LPS) or saline. Dams were treated with subcutaneous saline/ MG (270 mg/kg followed by 27 mg/kg q20 minutes) for 2 hours before and following LPS/saline injections. Pups were delivered spontaneously. At 1 and 3 months of age, 11-12 offspring of each group (Saline, LPS, MG, LPS-MG) underwent two-way shuttle box avoidance testing. The shuttle box is divided in half and the animal moves betwee...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772550]").text(description); $(".js-view-count[data-work-id=96772550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=96772550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772550,"title":"Magnesium sulphate prevents maternal inflammation-induced impairment of learning ability and memory in the rat offspring","translated_title":"","metadata":{"abstract":"Maternal chorioamnionitis is associated with newborn neurologic injury. 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Pups were delivered spontaneously. At 1 and 3 months of age, 11-12 offspring of each group (Saline, LPS, MG, LPS-MG) underwent two-way shuttle box avoidance testing. The shuttle box is divided in half and the animal moves betwee...","internal_url":"https://www.academia.edu/96772550/Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring","translated_internal_url":"","created_at":"2023-02-12T09:38:31.341-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":362036,"name":"White matter","url":"https://www.academia.edu/Documents/in/White_matter"},{"id":439784,"name":"Saline","url":"https://www.academia.edu/Documents/in/Saline"},{"id":522464,"name":"Short Term Memory","url":"https://www.academia.edu/Documents/in/Short_Term_Memory"},{"id":640959,"name":"Chorioamnionitis","url":"https://www.academia.edu/Documents/in/Chorioamnionitis"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":987472,"name":"Gestation","url":"https://www.academia.edu/Documents/in/Gestation"},{"id":1279813,"name":"Magnesium Sulfate","url":"https://www.academia.edu/Documents/in/Magnesium_Sulfate"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"},{"id":2451403,"name":"Avoidance Learning","url":"https://www.academia.edu/Documents/in/Avoidance_Learning"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772549"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772549/Adaptive_shut_down_of_EEG_activity_predicts_critical_acidemia_in_the_near_term_ovine_fetus"><img alt="Research paper thumbnail of Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus" class="work-thumbnail" src="https://attachments.academia-assets.com/98578133/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772549/Adaptive_shut_down_of_EEG_activity_predicts_critical_acidemia_in_the_near_term_ovine_fetus">Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus</a></div><div class="wp-workCard_item"><span>Physiological reports</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In fetal sheep, the electrocorticogram (ECOG) recorded directly from the cortex during repetitive...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In fetal sheep, the electrocorticogram (ECOG) recorded directly from the cortex during repetitive heart rate (FHR) decelerations induced by umbilical cord occlusions (UCO) predictably correlates with worsening hypoxic-acidemia. In human fetal monitoring during labor, the equivalent electroencephalogram (EEG) can be recorded noninvasively from the scalp. We tested the hypothesis that combined fetal EEG - FHR monitoring allows for early detection of worsening hypoxic-acidemia similar to that shown for ECOG-FHR monitoring. Near-term fetal sheep (n = 9) were chronically instrumented with arterial and venous catheters, ECG, ECOG, and EEG electrodes and umbilical cord occluder, followed by 4 days of recovery. Repetitive UCOs of 1 min duration and increasing strength (with regard to the degree of reduction in umbilical blood flow) were induced each 2.5 min until pH dropped to &lt;7.00. Repetitive UCOs led to marked acidosis (arterial pH 7.35 ± 0.01 to 7.00 ± 0.03). At pH of 7.22 ± 0.03 (ra...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="933bce0f58cef7029022581464c2eb9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578133,"asset_id":96772549,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578133/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772549"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772549"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772549; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772549]").text(description); $(".js-view-count[data-work-id=96772549]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772549; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772549']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772549, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "933bce0f58cef7029022581464c2eb9f" } } $('.js-work-strip[data-work-id=96772549]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772549,"title":"Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus","translated_title":"","metadata":{"abstract":"In fetal sheep, the electrocorticogram (ECOG) recorded directly from the cortex during repetitive heart rate (FHR) decelerations induced by umbilical cord occlusions (UCO) predictably correlates with worsening hypoxic-acidemia. 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Repetitive UCOs of 1 min duration and increasing strength (with regard to the degree of reduction in umbilical blood flow) were induced each 2.5 min until pH dropped to \u0026lt;7.00. Repetitive UCOs led to marked acidosis (arterial pH 7.35 ± 0.01 to 7.00 ± 0.03). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772548"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772548/Early_life_influences_on_obesity_from_preconception_to_adolescence"><img alt="Research paper thumbnail of Early-life influences on obesity: from preconception to adolescence" class="work-thumbnail" src="https://attachments.academia-assets.com/98578131/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772548/Early_life_influences_on_obesity_from_preconception_to_adolescence">Early-life influences on obesity: from preconception to adolescence</a></div><div class="wp-workCard_item"><span>Annals of the New York Academy of Sciences</span><span>, Jan 2, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The double burden of under- and overnutrition profoundly affects human health globally. According...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff459ce23c6d6b89bd688e719333c130" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578131,"asset_id":96772548,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578131/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772548"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772548"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772548; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772548]").text(description); $(".js-view-count[data-work-id=96772548]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772548; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772548']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772548, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ff459ce23c6d6b89bd688e719333c130" } } $('.js-work-strip[data-work-id=96772548]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772548,"title":"Early-life influences on obesity: from preconception to adolescence","translated_title":"","metadata":{"abstract":"The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.","publication_date":{"day":2,"month":1,"year":2015,"errors":{}},"publication_name":"Annals of the New York Academy of Sciences"},"translated_abstract":"The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.","internal_url":"https://www.academia.edu/96772548/Early_life_influences_on_obesity_from_preconception_to_adolescence","translated_internal_url":"","created_at":"2023-02-12T09:38:31.081-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578131/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/98578131/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_life_influences_on_obesity_from_pr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578131/ptpmcrender-libre.pdf?1676224575=\u0026response-content-disposition=attachment%3B+filename%3DEarly_life_influences_on_obesity_from_pr.pdf\u0026Expires=1733240517\u0026Signature=g7cUsQUD08RbHR8V-tnrrYaOYqLFpfAlIOLSXkt4xPr3XbQQVNVcEVQ1yue0cmkZRatf7tuamh4LhYVCcCtVVOgyaBDwQmdAtqcLinylHQMMlYwgpbxKn~NSQoOI5p1UM9gQTEoLGQBitG9ULGggTuTQhsQhTPkgw8dgB-0-g9FN0pULYWlCJG9Fq9I0A~k58OaB9WZb92Kf2SQ5H1Fn6FIR6SA-GmxEDhQIP0uaNVWx5KIiKIbXhtVPidondEppjuf4Gukrg3MKcr4BntOl7V4wwkMp~SSNSNlT7bzjtAPTukjtdO~H38inJd7WNzYYNYRZfyBRXstFpZcXn5UO4w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Early_life_influences_on_obesity_from_preconception_to_adolescence","translated_slug":"","page_count":42,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578131/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/98578131/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_life_influences_on_obesity_from_pr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578131/ptpmcrender-libre.pdf?1676224575=\u0026response-content-disposition=attachment%3B+filename%3DEarly_life_influences_on_obesity_from_pr.pdf\u0026Expires=1733240517\u0026Signature=g7cUsQUD08RbHR8V-tnrrYaOYqLFpfAlIOLSXkt4xPr3XbQQVNVcEVQ1yue0cmkZRatf7tuamh4LhYVCcCtVVOgyaBDwQmdAtqcLinylHQMMlYwgpbxKn~NSQoOI5p1UM9gQTEoLGQBitG9ULGggTuTQhsQhTPkgw8dgB-0-g9FN0pULYWlCJG9Fq9I0A~k58OaB9WZb92Kf2SQ5H1Fn6FIR6SA-GmxEDhQIP0uaNVWx5KIiKIbXhtVPidondEppjuf4Gukrg3MKcr4BntOl7V4wwkMp~SSNSNlT7bzjtAPTukjtdO~H38inJd7WNzYYNYRZfyBRXstFpZcXn5UO4w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1048,"name":"Health Behavior","url":"https://www.academia.edu/Documents/in/Health_Behavior"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism"},{"id":63375,"name":"Overweight","url":"https://www.academia.edu/Documents/in/Overweight"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise"},{"id":290613,"name":"Diathesis","url":"https://www.academia.edu/Documents/in/Diathesis"},{"id":369093,"name":"Food habits","url":"https://www.academia.edu/Documents/in/Food_habits"},{"id":443581,"name":"Breast feeding","url":"https://www.academia.edu/Documents/in/Breast_feeding"},{"id":546430,"name":"Food Preferences","url":"https://www.academia.edu/Documents/in/Food_Preferences"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772547"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772547/Intrauterine_growth_restriction_increases_the_preference_for_palatable_foods_and_affects_sensitivity_to_food_rewards_in_male_and_female_adult_rats"><img alt="Research paper thumbnail of Intrauterine growth restriction increases the preference for palatable foods and affects sensitivity to food rewards in male and female adult rats" class="work-thumbnail" src="https://attachments.academia-assets.com/98578167/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772547/Intrauterine_growth_restriction_increases_the_preference_for_palatable_foods_and_affects_sensitivity_to_food_rewards_in_male_and_female_adult_rats">Intrauterine growth restriction increases the preference for palatable foods and affects sensitivity to food rewards in male and female adult rats</a></div><div class="wp-workCard_item"><span>Brain Research</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="87c81697ea5639ff4fa59273efc92dc9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578167,"asset_id":96772547,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578167/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772547"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772547"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772547; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "87c81697ea5639ff4fa59273efc92dc9" } } $('.js-work-strip[data-work-id=96772547]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772547,"title":"Intrauterine growth restriction increases the preference for palatable foods and affects sensitivity to food rewards in male and female adult rats","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Clinical evidence suggests that intrauterine growth restriction (IUGR) can cause persistent changes in the preference for palatable foods. In this study, we compared food preferences, the response to food rewards, and the role of the mesolimbic dopaminergic system in feeding behavior, between IUGR and control rats. Time-mated pregnant Sprague-Dawley rats were randomly allocated to a control group (standard chow ad libitum) or a 50% food restriction (FR) group, which received 50% of the control dams' habitual intake. These diets were provided from gestation day 10 to the 21st day of lactation. Within 24 h of birth, pups were cross-fostered and divided into four groups: Adlib/Adlib, FR/Adlib, FR/FR, Adlib/FR. Standard chow consumption was compared between all groups. Food preferences, conditioned place preference to a palatable diet, and the levels of tyrosine hydroxylase (TH) phosphorylation and D2 receptors in the nucleus accumbens were analyzed and compared between the two groups of interest: Adlib/Adlib (control) and FR/Adlib (exposed to growth restriction during the fetal period only). IUGR adult rats had a stronger preference for palatable foods, but showed less conditioned place preference to a palatable diet than controls. D2 receptors levels were lower in IUGR rats. At baseline, TH and pTH levels were higher in FR/Adlib than control males. Measurements taken after exposure to sweet foods revealed higher levels of TH and pTH in FR/Adlib than control females. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772546"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772546/Maternal_High_Fat_Diet_Programs_Rat_Offspring_Liver_Fatty_Acid_Metabolism"><img alt="Research paper thumbnail of Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism" class="work-thumbnail" src="https://attachments.academia-assets.com/98578146/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772546/Maternal_High_Fat_Diet_Programs_Rat_Offspring_Liver_Fatty_Acid_Metabolism">Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism</a></div><div class="wp-workCard_item"><span>Lipids</span><span>, Jan 22, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8bda4f81a8498e6fb548c4cf84fa83c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578146,"asset_id":96772546,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578146/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772546"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772546"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772546; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772546]").text(description); $(".js-view-count[data-work-id=96772546]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772546; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772546']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772546, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8bda4f81a8498e6fb548c4cf84fa83c1" } } $('.js-work-strip[data-work-id=96772546]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772546,"title":"Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism","translated_title":"","metadata":{"abstract":"In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions w...","publication_date":{"day":22,"month":1,"year":2015,"errors":{}},"publication_name":"Lipids"},"translated_abstract":"In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions w...","internal_url":"https://www.academia.edu/96772546/Maternal_High_Fat_Diet_Programs_Rat_Offspring_Liver_Fatty_Acid_Metabolism","translated_internal_url":"","created_at":"2023-02-12T09:38:30.774-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578146,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578146/thumbnails/1.jpg","file_name":"pmc4451084.pdf","download_url":"https://www.academia.edu/attachments/98578146/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_High_Fat_Diet_Programs_Rat_Offs.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578146/pmc4451084-libre.pdf?1676224572=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_High_Fat_Diet_Programs_Rat_Offs.pdf\u0026Expires=1733240517\u0026Signature=EjMpPEpWBZ78~eD8L3NB2ls8~ADOe0RwGU-l1dkx4Kc0cHTM9I7DLOrUSjpf6V~1NDmK5CoCADRgCDDZskC2oD96gk4Pn8ft5j5QnN32XJC7EHx3RE3J1j5D9eB4BfviDwIlggEDkCeXxyLNw1jCI4vzSfFnVyubZFniIMPz5~tBoGqwkd0Ov-HtHRdEJ6p5yyXR7bVMYQNpLnRhw5lgcM3A7aIhJN-oxd-DKmgnINjLn1u~2DC2G7LZUVAGEU0ppjY4VgYVwbbFL~SiyumEBPBqaS8kdxTwRwD5jblj3ZAwpH~jjwa~pv-0ATgrkr8ZCbdxHiHbgUiJKMxMFUs6Rg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Maternal_High_Fat_Diet_Programs_Rat_Offspring_Liver_Fatty_Acid_Metabolism","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578146,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578146/thumbnails/1.jpg","file_name":"pmc4451084.pdf","download_url":"https://www.academia.edu/attachments/98578146/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_High_Fat_Diet_Programs_Rat_Offs.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578146/pmc4451084-libre.pdf?1676224572=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_High_Fat_Diet_Programs_Rat_Offs.pdf\u0026Expires=1733240517\u0026Signature=EjMpPEpWBZ78~eD8L3NB2ls8~ADOe0RwGU-l1dkx4Kc0cHTM9I7DLOrUSjpf6V~1NDmK5CoCADRgCDDZskC2oD96gk4Pn8ft5j5QnN32XJC7EHx3RE3J1j5D9eB4BfviDwIlggEDkCeXxyLNw1jCI4vzSfFnVyubZFniIMPz5~tBoGqwkd0Ov-HtHRdEJ6p5yyXR7bVMYQNpLnRhw5lgcM3A7aIhJN-oxd-DKmgnINjLn1u~2DC2G7LZUVAGEU0ppjY4VgYVwbbFL~SiyumEBPBqaS8kdxTwRwD5jblj3ZAwpH~jjwa~pv-0ATgrkr8ZCbdxHiHbgUiJKMxMFUs6Rg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":19826,"name":"Lactation","url":"https://www.academia.edu/Documents/in/Lactation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52055,"name":"Lipids","url":"https://www.academia.edu/Documents/in/Lipids"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":1260596,"name":"Palmitic Acid","url":"https://www.academia.edu/Documents/in/Palmitic_Acid"},{"id":2069623,"name":"Stearoyl-CoA desaturase","url":"https://www.academia.edu/Documents/in/Stearoyl-CoA_desaturase"},{"id":3086922,"name":"palmitoleic acid","url":"https://www.academia.edu/Documents/in/palmitoleic_acid"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":4142672,"name":"Maternal Nutritional Physiological Phenomena","url":"https://www.academia.edu/Documents/in/Maternal_Nutritional_Physiological_Phenomena"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="17104935" id="papers"><div class="js-work-strip profile--work_container" data-work-id="96772761"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772761/Antenatal_thyrotropin_releasing_hormone_TRH_for_fetal_pulmonary_maturation_Two_concurrent_randomised_controlled_trials"><img alt="Research paper thumbnail of Antenatal thyrotropin releasing hormone (TRH) for fetal pulmonary maturation: Two concurrent randomised controlled trials" class="work-thumbnail" src="https://attachments.academia-assets.com/98578277/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772761/Antenatal_thyrotropin_releasing_hormone_TRH_for_fetal_pulmonary_maturation_Two_concurrent_randomised_controlled_trials">Antenatal thyrotropin releasing hormone (TRH) for fetal pulmonary maturation: Two concurrent randomised controlled trials</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e7fa5199abdd3884cc968ce70141047" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578277,"asset_id":96772761,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578277/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772761"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772761"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772761; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772564"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772564/Maternal_pomegranate_juice_attenuates_maternal_inflammation_induced_fetal_brain_injury_by_inhibition_of_apoptosis_neuronal_nitric_oxide_synthase_and_NF_%CE%BAB_in_a_rat_model"><img alt="Research paper thumbnail of Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model" class="work-thumbnail" src="https://attachments.academia-assets.com/98578140/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772564/Maternal_pomegranate_juice_attenuates_maternal_inflammation_induced_fetal_brain_injury_by_inhibition_of_apoptosis_neuronal_nitric_oxide_synthase_and_NF_%CE%BAB_in_a_rat_model">Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. Pregnant rats (24 total) were randomized for intraperitoneal lipopolysaccharide (100 μg/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5 mL per day), resulting in 4 groups of 6 dams (saline/saline, pomegranate juice/saline, saline/lipopolysaccharide, pomegranate juice/lipopolysaccharide). All dams were sacrificed 4 hours following the injection and maternal blood and fetal brains were collected from the 4 treatment groups. Maternal interleukin-6 serum levels and fetal brain caspase 3 active form, n...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff0a61c50735af6cf8e4ef0c7af569c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578140,"asset_id":96772564,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578140/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772564"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772564"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772564; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772564]").text(description); $(".js-view-count[data-work-id=96772564]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772564; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772564']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772564, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ff0a61c50735af6cf8e4ef0c7af569c5" } } $('.js-work-strip[data-work-id=96772564]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772564,"title":"Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model","translated_title":"","metadata":{"abstract":"Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. Pregnant rats (24 total) were randomized for intraperitoneal lipopolysaccharide (100 μg/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5 mL per day), resulting in 4 groups of 6 dams (saline/saline, pomegranate juice/saline, saline/lipopolysaccharide, pomegranate juice/lipopolysaccharide). All dams were sacrificed 4 hours following the injection and maternal blood and fetal brains were collected from the 4 treatment groups. Maternal interleukin-6 serum levels and fetal brain caspase 3 active form, n...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. Pregnant rats (24 total) were randomized for intraperitoneal lipopolysaccharide (100 μg/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5 mL per day), resulting in 4 groups of 6 dams (saline/saline, pomegranate juice/saline, saline/lipopolysaccharide, pomegranate juice/lipopolysaccharide). All dams were sacrificed 4 hours following the injection and maternal blood and fetal brains were collected from the 4 treatment groups. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772563/Transfer_of_Inhaled_Cannabis_Into_Human_Breast_Milk"><img alt="Research paper thumbnail of Transfer of Inhaled Cannabis Into Human Breast Milk" class="work-thumbnail" src="https://attachments.academia-assets.com/98578125/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772563/Transfer_of_Inhaled_Cannabis_Into_Human_Breast_Milk">Transfer of Inhaled Cannabis Into Human Breast Milk</a></div><div class="wp-workCard_item"><span>Obstetrics and gynecology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast mi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. In this pilot pharmacokinetic study, breast milk samples were collected from mothers who regularly consumed cannabis, were 2-5 months postpartum, and exclusively breastfeeding their infants. Women were anonymously recruited for the study. After discontinuing cannabis for at least 24 hours, they were directed to obtain a baseline breast milk sample, then smoke a preweighed, analyzed, standardized strain of cannabis from one preselected dispensary, and collect breast milk samples at specific time points: 20 minutes and 1, 2, and 4 hours. Quantification of delta-9-tetrahydrocannabinol and its metabolites in these collected breast milk samples was performed by high-performance liquid chromatography tandem mass spectrometry. A total of eight women were enrolled. Most were occasional cannabis smokers...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a0663ce46cd4f19e7fe5c16591e3384" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578125,"asset_id":96772563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578125/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772563; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772563]").text(description); $(".js-view-count[data-work-id=96772563]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772563; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772563']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772563, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a0663ce46cd4f19e7fe5c16591e3384" } } $('.js-work-strip[data-work-id=96772563]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772563,"title":"Transfer of Inhaled Cannabis Into Human Breast Milk","translated_title":"","metadata":{"abstract":"To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis containing 23.18% delta-9-tetrahydrocannabinol. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772562"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772562/In_vivo_maternal_and_in_vitro_BPA_exposure_effects_on_hypothalamic_neurogenesis_and_appetite_regulators"><img alt="Research paper thumbnail of In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators" class="work-thumbnail" src="https://attachments.academia-assets.com/98578126/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772562/In_vivo_maternal_and_in_vitro_BPA_exposure_effects_on_hypothalamic_neurogenesis_and_appetite_regulators">In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators</a></div><div class="wp-workCard_item"><span>Environmental research</span><span>, Jan 21, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. As food intake/appetite is one of the critical elements contributing to obesity, we determined the effects of in vivo maternal BPA and in vitro BPA exposure on newborn hypothalamic stem cells which form the arcuate nucleus appetite center. For in vivo studies, female rats received BPA prior to and during pregnancy via drinking water, and newborn offspring primary hypothalamic neuroprogenitor (NPCs) were obtained and cultured. For in vitro BPA exposure, primary hypothalamic NPCs from healthy newborns were utilized. In both cases, we studied the effects of BPA on NPC proliferation and differentiation, including putative signal and appetite factors. Maternal BPA increased hypothalamic NPC proliferation and differentiation in newborns, in conjunction with increased neuroproliferative (Hes1) and proneurogenic (Ngn3) protein expression. With NPC differentiation, BPA exposure increased ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="473fb9d75698acf3461d19437027222a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578126,"asset_id":96772562,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578126/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772562"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772562; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772562]").text(description); $(".js-view-count[data-work-id=96772562]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772562; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772562']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772562, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "473fb9d75698acf3461d19437027222a" } } $('.js-work-strip[data-work-id=96772562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772562,"title":"In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators","translated_title":"","metadata":{"abstract":"In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with offspring obesity. 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Maternal BPA increased hypothalamic NPC proliferation and differentiation in newborns, in conjunction with increased neuroproliferative (Hes1) and proneurogenic (Ngn3) protein expression. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772561/Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_"><img alt="Research paper thumbnail of Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)" class="work-thumbnail" src="https://attachments.academia-assets.com/98578124/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772561/Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_">Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)</a></div><div class="wp-workCard_item"><span>Neuroscience</span><span>, Jan 8, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal infection/inflammation may induce fetal inflammatory responses, which have been associat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal infection/inflammation may induce fetal inflammatory responses, which have been associated with long-term offspring cerebral injury. We previously demonstrated that prophylactic N-Acetyl-Cysteine (NAC), administered prior to and following maternal lipopolysaccharide (LPS), reduced offspring cerebral injury as evident on MRI. In the present study, we used MRI to examine the effect of therapeutic NAC following maternal LPS-induced inflammation on neonatal brain injury. Pregnant Sprague-Dawley dams (n = 6) at day 18 of gestation received either intraperitoneal injection of LPS or saline (Control) at time 0. Animals were randomized to receive intravenous injection (tail vein) of NAC or saline at time +30 min. Pups were delivered spontaneously and allowed to mature until postnatal day 25. Male offspring (6-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion Tensor Imaging (DTI), an advanced MRI technique, was performed and quantitative parameters...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f5d6dc7b174b6ac53b65b74386af0b68" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578124,"asset_id":96772561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578124/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772561]").text(description); $(".js-view-count[data-work-id=96772561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772561, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f5d6dc7b174b6ac53b65b74386af0b68" } } $('.js-work-strip[data-work-id=96772561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772561,"title":"Therapeutic N-Acetyl-Cysteine (Nac) Following Initiation of Maternal Inflammation Attenuates Long-Term Offspring Cerebral Injury, as Evident in Magnetic Resonance Imaging (MRI)","translated_title":"","metadata":{"abstract":"Maternal infection/inflammation may induce fetal inflammatory responses, which have been associated with long-term offspring cerebral injury. We previously demonstrated that prophylactic N-Acetyl-Cysteine (NAC), administered prior to and following maternal lipopolysaccharide (LPS), reduced offspring cerebral injury as evident on MRI. In the present study, we used MRI to examine the effect of therapeutic NAC following maternal LPS-induced inflammation on neonatal brain injury. Pregnant Sprague-Dawley dams (n = 6) at day 18 of gestation received either intraperitoneal injection of LPS or saline (Control) at time 0. Animals were randomized to receive intravenous injection (tail vein) of NAC or saline at time +30 min. Pups were delivered spontaneously and allowed to mature until postnatal day 25. Male offspring (6-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion Tensor Imaging (DTI), an advanced MRI technique, was performed and quantitative parameters...","publication_date":{"day":8,"month":1,"year":2018,"errors":{}},"publication_name":"Neuroscience"},"translated_abstract":"Maternal infection/inflammation may induce fetal inflammatory responses, which have been associated with long-term offspring cerebral injury. We previously demonstrated that prophylactic N-Acetyl-Cysteine (NAC), administered prior to and following maternal lipopolysaccharide (LPS), reduced offspring cerebral injury as evident on MRI. In the present study, we used MRI to examine the effect of therapeutic NAC following maternal LPS-induced inflammation on neonatal brain injury. Pregnant Sprague-Dawley dams (n = 6) at day 18 of gestation received either intraperitoneal injection of LPS or saline (Control) at time 0. Animals were randomized to receive intravenous injection (tail vein) of NAC or saline at time +30 min. Pups were delivered spontaneously and allowed to mature until postnatal day 25. Male offspring (6-8 per group) were examined by MRI and analyzed using voxel-based analysis. Diffusion Tensor Imaging (DTI), an advanced MRI technique, was performed and quantitative parameters...","internal_url":"https://www.academia.edu/96772561/Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_","translated_internal_url":"","created_at":"2023-02-12T09:38:32.826-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578124,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578124/thumbnails/1.jpg","file_name":"j.neuroscience.2018.01.01320230212-1-pzt0j1.pdf","download_url":"https://www.academia.edu/attachments/98578124/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578124/j.neuroscience.2018.01.01320230212-1-pzt0j1-libre.pdf?1676224573=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf\u0026Expires=1733240517\u0026Signature=S4bLRe8UqoCyzjBigt8995tNbdvaU5OoI3gpohrlsCPJCi8CJXzRLVgtUbUyHCd6zh2TIdzlg4KykInD51rWPLca-HA~Pvhv41JSzT9GT4WHA~d-wSDJhfzzIBCfkvIvq7FyKuTY2weipIVMXPZKEafwoLcOi5FAP-uB92bfb20~6Z~274~qczby4Bk253wvsJqmUy79AGzRe9~~ftjhPyy0CZETyRoSZiFpjw38VlzQEhI~YKRLCC6-vC3CqJC5yw0~HCtHZwhvNGw288YoEtNhaVcqoxmv8ca6P45hDRtYjpsouznBzpoAM9F7C56LD0XELCp8Xm3d~TaoResxtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Therapeutic_N_Acetyl_Cysteine_Nac_Following_Initiation_of_Maternal_Inflammation_Attenuates_Long_Term_Offspring_Cerebral_Injury_as_Evident_in_Magnetic_Resonance_Imaging_MRI_","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578124,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578124/thumbnails/1.jpg","file_name":"j.neuroscience.2018.01.01320230212-1-pzt0j1.pdf","download_url":"https://www.academia.edu/attachments/98578124/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578124/j.neuroscience.2018.01.01320230212-1-pzt0j1-libre.pdf?1676224573=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_N_Acetyl_Cysteine_Nac_Follow.pdf\u0026Expires=1733240517\u0026Signature=S4bLRe8UqoCyzjBigt8995tNbdvaU5OoI3gpohrlsCPJCi8CJXzRLVgtUbUyHCd6zh2TIdzlg4KykInD51rWPLca-HA~Pvhv41JSzT9GT4WHA~d-wSDJhfzzIBCfkvIvq7FyKuTY2weipIVMXPZKEafwoLcOi5FAP-uB92bfb20~6Z~274~qczby4Bk253wvsJqmUy79AGzRe9~~ftjhPyy0CZETyRoSZiFpjw38VlzQEhI~YKRLCC6-vC3CqJC5yw0~HCtHZwhvNGw288YoEtNhaVcqoxmv8ca6P45hDRtYjpsouznBzpoAM9F7C56LD0XELCp8Xm3d~TaoResxtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":41216,"name":"Diffusion MRI","url":"https://www.academia.edu/Documents/in/Diffusion_MRI"},{"id":362036,"name":"White matter","url":"https://www.academia.edu/Documents/in/White_matter"},{"id":640959,"name":"Chorioamnionitis","url":"https://www.academia.edu/Documents/in/Chorioamnionitis"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772560"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772560/Prolonged_Prenatal_Hypernatremia_Alters_Neuroendocrine_and_Electrolyte_Homeostasis_in_Neonatal_Sheep1"><img alt="Research paper thumbnail of Prolonged Prenatal Hypernatremia Alters Neuroendocrine and Electrolyte Homeostasis in Neonatal Sheep1" class="work-thumbnail" src="https://attachments.academia-assets.com/98578153/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772560/Prolonged_Prenatal_Hypernatremia_Alters_Neuroendocrine_and_Electrolyte_Homeostasis_in_Neonatal_Sheep1">Prolonged Prenatal Hypernatremia Alters Neuroendocrine and Electrolyte Homeostasis in Neonatal Sheep1</a></div><div class="wp-workCard_item"><span>Experimental Biology and Medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Arginine vasopressin (AVP) is a neuroendocrine hormone synthesized in the hypothalamus, and is st...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Arginine vasopressin (AVP) is a neuroendocrine hormone synthesized in the hypothalamus, and is stored and secreted by the posterior pituitary gland in response to stimuli such as plasma hypertonicity and hypotension. The primary physiologic roles of AVP include plasma osmolality and blood pressure regulation. We have previously demonstrated that chronic prenatal plasma hypertonicity alters the AVP regulatory pathway in newborn lambs. The objectives of the present study were to evaluate prolonged effects of antenatal plasma hypertonicity on neonatal plasma osmoregulation. Pregnant ewes at 119 ± 3 days of gestation were water restricted to achieve and maintain hypertonicity until normal-term delivery. After delivery, ewes were provided food and water ad libitum and lambs were allowed maternal nursing. At the age of 28 days, blood samples were obtained for the analysis of plasma osmolality, electrolytes, and AVP levels from study (n = 5) and age-matched control (n = 6) lambs. Subsequen...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fb26d92a6523d201f0fffcef36049f9f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578153,"asset_id":96772560,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578153/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772560"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772560"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772560; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772560]").text(description); $(".js-view-count[data-work-id=96772560]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772560; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772560']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772560, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fb26d92a6523d201f0fffcef36049f9f" } } $('.js-work-strip[data-work-id=96772560]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772560,"title":"Prolonged Prenatal Hypernatremia Alters Neuroendocrine and Electrolyte Homeostasis in Neonatal Sheep1","translated_title":"","metadata":{"abstract":"Arginine vasopressin (AVP) is a neuroendocrine hormone synthesized in the hypothalamus, and is stored and secreted by the posterior pituitary gland in response to stimuli such as plasma hypertonicity and hypotension. The primary physiologic roles of AVP include plasma osmolality and blood pressure regulation. We have previously demonstrated that chronic prenatal plasma hypertonicity alters the AVP regulatory pathway in newborn lambs. The objectives of the present study were to evaluate prolonged effects of antenatal plasma hypertonicity on neonatal plasma osmoregulation. Pregnant ewes at 119 ± 3 days of gestation were water restricted to achieve and maintain hypertonicity until normal-term delivery. After delivery, ewes were provided food and water ad libitum and lambs were allowed maternal nursing. At the age of 28 days, blood samples were obtained for the analysis of plasma osmolality, electrolytes, and AVP levels from study (n = 5) and age-matched control (n = 6) lambs. 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After delivery, ewes were provided food and water ad libitum and lambs were allowed maternal nursing. At the age of 28 days, blood samples were obtained for the analysis of plasma osmolality, electrolytes, and AVP levels from study (n = 5) and age-matched control (n = 6) lambs. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772559/Meeting_summary_the_inaugural_meeting_of_the_US_DOHaD_society"><img alt="Research paper thumbnail of Meeting summary: the inaugural meeting of the US DOHaD society" class="work-thumbnail" src="https://attachments.academia-assets.com/98578051/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772559/Meeting_summary_the_inaugural_meeting_of_the_US_DOHaD_society">Meeting summary: the inaugural meeting of the US DOHaD society</a></div><div class="wp-workCard_item"><span>Environmental Epigenetics</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="97d446824a5917e83ef6972d03bb7e8c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578051,"asset_id":96772559,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578051/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772559; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772557"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772557/Maternal_bisphenol_A_exposure_alters_rat_offspring_hepatic_and_skeletal_muscle_insulin_signaling_protein_abundance"><img alt="Research paper thumbnail of Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance" class="work-thumbnail" src="https://attachments.academia-assets.com/98578168/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772557/Maternal_bisphenol_A_exposure_alters_rat_offspring_hepatic_and_skeletal_muscle_insulin_signaling_protein_abundance">Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Mar 9, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The obesogenic and diabetogenic effects of the environmental toxin bisphenol A during critical wi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The obesogenic and diabetogenic effects of the environmental toxin bisphenol A during critical windows of development are well recognized. Liver and skeletal muscle play a central role in the control of glucose production, utilization, and storage. We hypothesized that maternal bisphenol A exposure disrupts insulin signaling in rat offspring liver and skeletal muscle. We determined the protein expression of hepatic and skeletal muscle insulin signaling molecules including insulin receptor beta, its downstream target insulin receptor substrate 1 and glucose transporters (glucose transporter 2, glucose transporter 4), and hepatic glucose-regulating enzymes phosphoenolpyruvate carboxykinase and glucokinase. Rat dams had ad libitum access to filtered drinking water (control) or drinking water with bisphenol A from 2 weeks prior to mating and through pregnancy and lactation. Offspring litters were standardized to 4 males and 4 females and nursed by the same dam. 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At weaning, bisphenol A e...","publication_date":{"day":9,"month":3,"year":2016,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"The obesogenic and diabetogenic effects of the environmental toxin bisphenol A during critical windows of development are well recognized. Liver and skeletal muscle play a central role in the control of glucose production, utilization, and storage. We hypothesized that maternal bisphenol A exposure disrupts insulin signaling in rat offspring liver and skeletal muscle. We determined the protein expression of hepatic and skeletal muscle insulin signaling molecules including insulin receptor beta, its downstream target insulin receptor substrate 1 and glucose transporters (glucose transporter 2, glucose transporter 4), and hepatic glucose-regulating enzymes phosphoenolpyruvate carboxykinase and glucokinase. Rat dams had ad libitum access to filtered drinking water (control) or drinking water with bisphenol A from 2 weeks prior to mating and through pregnancy and lactation. Offspring litters were standardized to 4 males and 4 females and nursed by the same dam. At weaning, bisphenol A e...","internal_url":"https://www.academia.edu/96772557/Maternal_bisphenol_A_exposure_alters_rat_offspring_hepatic_and_skeletal_muscle_insulin_signaling_protein_abundance","translated_internal_url":"","created_at":"2023-02-12T09:38:32.298-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578168,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578168/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/98578168/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_bisphenol_A_exposure_alters_rat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578168/ptpmcrender-libre.pdf?1676224564=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_bisphenol_A_exposure_alters_rat.pdf\u0026Expires=1733240517\u0026Signature=LZYpGOljYDyVvjC5iXAYRujFZEc7IMYXsGDOOO4iux-cxoJ7R1q1fQi1oOvyUJxwXA-QmH1eYhacJfnwbhYGspWCKHWI898jG6WaAuV3pn2HHgUSFBxM4d3oCnpQX2z1sBdiS-cUBZ1ZLQK8~qasFL9qIEfqBX2pD9nTOWmGNDbvPw5m2ZvYiyP9pRg0nV6qnPtTrZZx9ireMDmdaz0qBbuzv-CMsnPUW4BY6PRmf3E3eztSzU172XeVEmgYoOb5gsU4AZ~7nN6nseg9nT4q7AmgpkCXmODo73FdGYB8Y508YrcWqC-zCU3LyAT0AwqQrAheLaH4Ha7TssI9H4zrNg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Maternal_bisphenol_A_exposure_alters_rat_offspring_hepatic_and_skeletal_muscle_insulin_signaling_protein_abundance","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578168,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578168/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/98578168/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Maternal_bisphenol_A_exposure_alters_rat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578168/ptpmcrender-libre.pdf?1676224564=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_bisphenol_A_exposure_alters_rat.pdf\u0026Expires=1733240517\u0026Signature=LZYpGOljYDyVvjC5iXAYRujFZEc7IMYXsGDOOO4iux-cxoJ7R1q1fQi1oOvyUJxwXA-QmH1eYhacJfnwbhYGspWCKHWI898jG6WaAuV3pn2HHgUSFBxM4d3oCnpQX2z1sBdiS-cUBZ1ZLQK8~qasFL9qIEfqBX2pD9nTOWmGNDbvPw5m2ZvYiyP9pRg0nV6qnPtTrZZx9ireMDmdaz0qBbuzv-CMsnPUW4BY6PRmf3E3eztSzU172XeVEmgYoOb5gsU4AZ~7nN6nseg9nT4q7AmgpkCXmODo73FdGYB8Y508YrcWqC-zCU3LyAT0AwqQrAheLaH4Ha7TssI9H4zrNg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":71445,"name":"Glucokinase","url":"https://www.academia.edu/Documents/in/Glucokinase"},{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":663539,"name":"Insulin Receptor","url":"https://www.academia.edu/Documents/in/Insulin_Receptor"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":1588981,"name":"Protein Biosynthesis","url":"https://www.academia.edu/Documents/in/Protein_Biosynthesis"},{"id":1878977,"name":"Maternal Exposure","url":"https://www.academia.edu/Documents/in/Maternal_Exposure"},{"id":3635727,"name":"Phosphoenolpyruvate carboxykinase","url":"https://www.academia.edu/Documents/in/Phosphoenolpyruvate_carboxykinase"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772556"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772556/Acardiac_twin_pregnancies_part_III_Model_simulations"><img alt="Research paper thumbnail of Acardiac twin pregnancies part III: Model simulations" class="work-thumbnail" src="https://attachments.academia-assets.com/98578165/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772556/Acardiac_twin_pregnancies_part_III_Model_simulations">Acardiac twin pregnancies part III: Model simulations</a></div><div class="wp-workCard_item"><span>Birth Defects Research Part A: Clinical and Molecular Teratology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d5070573fef88a676cc8664241acbf81" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578165,"asset_id":96772556,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578165/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772556"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772556"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772556; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772556]").text(description); $(".js-view-count[data-work-id=96772556]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772556; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772556']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772556, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d5070573fef88a676cc8664241acbf81" } } $('.js-work-strip[data-work-id=96772556]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772556,"title":"Acardiac twin pregnancies part III: Model simulations","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Background: Acardiac monochorionic twins lack cardiac function but grow by passive perfusion of the pump twin's deoxygenated arterial blood through placental arterioarterial (AA) and venovenous (VV) anastomoses and by hypoxia-mediated neovascularization. Pump twins therefore must continuously increase their cardiac output which may cause heart failure. Our aims were: to adapt our twin-twin transfusion syndrome model for acardiac twin pregnancies, to simulate pump and acardiac twin development, and to examine the model for early prognostic markers of pump twin survival. Methods: We used an infinite acardiac placental resistance, based on placental dye injection studies and simulations, suggesting the AA-Acardiac-VV series resistance determines the pump twin's excess cardiac output. Pump and acardiac development were expressed by the pump's excess cardiac output versus its normal value, represented by pump/acardiac umbilical venous diameter (UVD) ratios. Results: UVD ratios distinguish between AA-VV anastomoses that do and do not cause hydropic pump twins. Pump twins can handle relative larger acardiac perfusion at later than earlier gestation. Both VV and acardiac resistances are significantly smaller than the AA resistance, based on respectively clinical data and acardiac blood volumetric growth. Conclusion: Our simulations support clinical results which show that UVD ratios aid in the prediction of pump twin risk. The AA anastomosis controls the future of both the pump and the acardiac. Correlation between acardiac size and pump twin risk is secondary to the AA size but remains clinically usable. These factors may aid in the development of methods for pump twin prognosis and the promotion of selective clinical interventions.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Birth Defects Research Part A: Clinical and Molecular 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profile--work_container" data-work-id="96772555"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772555/Fatty_Acid_de_Novo_Synthesis_in_Adult_Intrauterine_Growth_Restricted_Offspring_and_Adult_Male_Response_to_a_High_Fat_Diet"><img alt="Research paper thumbnail of Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet" class="work-thumbnail" src="https://attachments.academia-assets.com/98578147/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772555/Fatty_Acid_de_Novo_Synthesis_in_Adult_Intrauterine_Growth_Restricted_Offspring_and_Adult_Male_Response_to_a_High_Fat_Diet">Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet</a></div><div class="wp-workCard_item"><span>Lipids</span><span>, Jan 22, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insulin resistance. We have previously shown that IUGR male rats demonstrated increased de novo fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, de novo synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid de novo synthesis in IUGR adult males (6 months) using deuterium-enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline de novo synthesis in both SC fat and visceral fat. Correspondingly, SC and visceral fat protein ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cd5e4741f0a289100f624cd8f5354052" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578147,"asset_id":96772555,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578147/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772555"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772555; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772555]").text(description); $(".js-view-count[data-work-id=96772555]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772555; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772555']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772555, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cd5e4741f0a289100f624cd8f5354052" } } $('.js-work-strip[data-work-id=96772555]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772555,"title":"Fatty Acid de Novo Synthesis in Adult Intrauterine Growth-Restricted Offspring, and Adult Male Response to a High Fat Diet","translated_title":"","metadata":{"abstract":"Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insulin resistance. We have previously shown that IUGR male rats demonstrated increased de novo fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, de novo synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid de novo synthesis in IUGR adult males (6 months) using deuterium-enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline de novo synthesis in both SC fat and visceral fat. Correspondingly, SC and visceral fat protein ...","ai_title_tag":"De Novo Fatty Acid Synthesis in IUGR Adult Male Rats","publication_date":{"day":22,"month":1,"year":2016,"errors":{}},"publication_name":"Lipids"},"translated_abstract":"Intrauterine growth restriction (IUGR) with rapid catch-up growth leads to adult obesity and insulin resistance. We have previously shown that IUGR male rats demonstrated increased de novo fatty acid synthesis in the subcutaneous (SC) fat, but not the visceral fat, during the nursing period prior to the onset of obesity. Young IUGR females do not exhibit the same increase. We further hypothesized that in male IUGR offspring, de novo synthesis is a programmed intrinsic effect that persists to adulthood and does not suppress in response to a high fat diet. We measured fatty acid de novo synthesis in IUGR adult males (6 months) using deuterium-enriched drinking water as a stable isotope tracer, then further studied the response after consumption of an isocaloric high fat diet. Baseline de novo synthesis in adult females was also studied at age 9 months. Males demonstrated increased baseline de novo synthesis in both SC fat and visceral fat. Correspondingly, SC and visceral fat protein ...","internal_url":"https://www.academia.edu/96772555/Fatty_Acid_de_Novo_Synthesis_in_Adult_Intrauterine_Growth_Restricted_Offspring_and_Adult_Male_Response_to_a_High_Fat_Diet","translated_internal_url":"","created_at":"2023-02-12T09:38:31.973-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578147,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578147/thumbnails/1.jpg","file_name":"s11745-016-4199-920230212-1-1nms4s5.pdf","download_url":"https://www.academia.edu/attachments/98578147/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Fatty_Acid_de_Novo_Synthesis_in_Adult_In.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578147/s11745-016-4199-920230212-1-1nms4s5-libre.pdf?1676224585=\u0026response-content-disposition=attachment%3B+filename%3DFatty_Acid_de_Novo_Synthesis_in_Adult_In.pdf\u0026Expires=1733240517\u0026Signature=LWxpP1StD9oPXSMt3dU0h-Wq8Zj04mkJpvV8a8VIJiFLSIbYZIkQ3nNjey7qnZQLbsn0swZuX8zQIIzOlwjrAj2dHW~Eo6-vSLvfZ8LrT8I3EVDzXGogsk1yTl3oxJGMlP99j8cLARFtl-80EJgFdpd2TK58adBWgUzcDGKz-1y98K~dDYlJxxWt7jzFg08btVmPwbDF7zxzGxbn6isYsmeYv8JtbsDdANEdxkccTnp09dpjw6p7RpZXMZxAVrSYNyCokxle0YKEtyyndUZOllzEOZrpqV~rSP2205CK-zCuLBekPGjR1PqSXc0GHdiuIAUaWdstM-eL00rJk5jJKg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Fatty_Acid_de_Novo_Synthesis_in_Adult_Intrauterine_Growth_Restricted_Offspring_and_Adult_Male_Response_to_a_High_Fat_Diet","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578147,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578147/thumbnails/1.jpg","file_name":"s11745-016-4199-920230212-1-1nms4s5.pdf","download_url":"https://www.academia.edu/attachments/98578147/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Fatty_Acid_de_Novo_Synthesis_in_Adult_In.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578147/s11745-016-4199-920230212-1-1nms4s5-libre.pdf?1676224585=\u0026response-content-disposition=attachment%3B+filename%3DFatty_Acid_de_Novo_Synthesis_in_Adult_In.pdf\u0026Expires=1733240517\u0026Signature=LWxpP1StD9oPXSMt3dU0h-Wq8Zj04mkJpvV8a8VIJiFLSIbYZIkQ3nNjey7qnZQLbsn0swZuX8zQIIzOlwjrAj2dHW~Eo6-vSLvfZ8LrT8I3EVDzXGogsk1yTl3oxJGMlP99j8cLARFtl-80EJgFdpd2TK58adBWgUzcDGKz-1y98K~dDYlJxxWt7jzFg08btVmPwbDF7zxzGxbn6isYsmeYv8JtbsDdANEdxkccTnp09dpjw6p7RpZXMZxAVrSYNyCokxle0YKEtyyndUZOllzEOZrpqV~rSP2205CK-zCuLBekPGjR1PqSXc0GHdiuIAUaWdstM-eL00rJk5jJKg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52055,"name":"Lipids","url":"https://www.academia.edu/Documents/in/Lipids"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71415,"name":"Fatty Acid Synthesis","url":"https://www.academia.edu/Documents/in/Fatty_Acid_Synthesis"},{"id":72314,"name":"Fatty acids","url":"https://www.academia.edu/Documents/in/Fatty_acids"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":1474278,"name":"Intrauterine Growth Restriction","url":"https://www.academia.edu/Documents/in/Intrauterine_Growth_Restriction"},{"id":2257736,"name":"Acetyl CoA Carboxylase","url":"https://www.academia.edu/Documents/in/Acetyl_CoA_Carboxylase"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":4039534,"name":"Fetal Growth Retardation","url":"https://www.academia.edu/Documents/in/Fetal_Growth_Retardation"},{"id":4116226,"name":"Subcutaneous fat","url":"https://www.academia.edu/Documents/in/Subcutaneous_fat"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772554"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772554/Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model"><img alt="Research paper thumbnail of Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772554/Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model">Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Sep 24, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal magnesium administration has been shown to protect the preterm fetus from white- and gra...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal magnesium administration has been shown to protect the preterm fetus from white- and gray-matter injury, although the mechanism is unknown. The purpose of the study is to test the following hypotheses: (1) maternal infections/inflammation activate fetal neuronal N-methyl-D-aspartate receptors that up-regulate neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells pathways; and (2) maternal magnesium sulfate attenuates fetal brain neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation through N-methyl-D-aspartate receptors. Pregnant rats at E16 and E18 (n = 6, 48 total) received injections of intraperitoneal lipopolysaccharide 500 μg/kg or saline at time 0. Dams were randomized for treatment with subcutaneous magnesium sulfate (270 mg/kg) or saline for 2 hours prior to and following lipopolysaccharide/saline injections. At 4 hours after lipopolysaccharide administration, fetal br...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772554"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772554"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772554; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772554]").text(description); $(".js-view-count[data-work-id=96772554]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772554; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772554']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772554, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=96772554]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772554,"title":"Maternal magnesium sulfate fetal neuroprotective effects to the fetus: inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model","translated_title":"","metadata":{"abstract":"Maternal magnesium administration has been shown to protect the preterm fetus from white- and gray-matter injury, although the mechanism is unknown. The purpose of the study is to test the following hypotheses: (1) maternal infections/inflammation activate fetal neuronal N-methyl-D-aspartate receptors that up-regulate neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells pathways; and (2) maternal magnesium sulfate attenuates fetal brain neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation through N-methyl-D-aspartate receptors. Pregnant rats at E16 and E18 (n = 6, 48 total) received injections of intraperitoneal lipopolysaccharide 500 μg/kg or saline at time 0. Dams were randomized for treatment with subcutaneous magnesium sulfate (270 mg/kg) or saline for 2 hours prior to and following lipopolysaccharide/saline injections. At 4 hours after lipopolysaccharide administration, fetal br...","publication_date":{"day":24,"month":9,"year":2016,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Maternal magnesium administration has been shown to protect the preterm fetus from white- and gray-matter injury, although the mechanism is unknown. The purpose of the study is to test the following hypotheses: (1) maternal infections/inflammation activate fetal neuronal N-methyl-D-aspartate receptors that up-regulate neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells pathways; and (2) maternal magnesium sulfate attenuates fetal brain neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation through N-methyl-D-aspartate receptors. Pregnant rats at E16 and E18 (n = 6, 48 total) received injections of intraperitoneal lipopolysaccharide 500 μg/kg or saline at time 0. Dams were randomized for treatment with subcutaneous magnesium sulfate (270 mg/kg) or saline for 2 hours prior to and following lipopolysaccharide/saline injections. At 4 hours after lipopolysaccharide administration, fetal br...","internal_url":"https://www.academia.edu/96772554/Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model","translated_internal_url":"","created_at":"2023-02-12T09:38:31.857-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Maternal_magnesium_sulfate_fetal_neuroprotective_effects_to_the_fetus_inhibition_of_neuronal_nitric_oxide_synthase_and_nuclear_factor_kappa_light_chain_enhancer_of_activated_B_cells_activation_in_a_rodent_model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide"},{"id":123418,"name":"NF-kappa B","url":"https://www.academia.edu/Documents/in/NF-kappa_B"},{"id":235677,"name":"Behavioral Animal Models","url":"https://www.academia.edu/Documents/in/Behavioral_Animal_Models"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":382388,"name":"Nitric Oxide Synthase","url":"https://www.academia.edu/Documents/in/Nitric_Oxide_Synthase"},{"id":1279813,"name":"Magnesium Sulfate","url":"https://www.academia.edu/Documents/in/Magnesium_Sulfate"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772553"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772553/Assessment_of_a_Cervicometer_Compared_to_Transvaginal_Ultrasound_in_Identifying_Women_with_a_Short_Cervical_Length_A_Multicenter_Study"><img alt="Research paper thumbnail of Assessment of a Cervicometer Compared to Transvaginal Ultrasound in Identifying Women with a Short Cervical Length: A Multicenter Study" class="work-thumbnail" src="https://attachments.academia-assets.com/98578162/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772553/Assessment_of_a_Cervicometer_Compared_to_Transvaginal_Ultrasound_in_Identifying_Women_with_a_Short_Cervical_Length_A_Multicenter_Study">Assessment of a Cervicometer Compared to Transvaginal Ultrasound in Identifying Women with a Short Cervical Length: A Multicenter Study</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Jan 17, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical length as measured by transvaginal ultrasound in the second trimester represents the single most predictive risk factor for spontaneous preterm birth. Previous studies have addressed, in part, the limitations of transvaginal ultrasound availability by utilizing a cervicometer to screen patients for short cervix, identifying those patients who may not benefit from transvaginal ultrasound cervical length screening. In view of the prior studies indicating that a cervicometer measurement may have a high negative predictive value for a sonographically short cervix, we sought to identify the ideal cervicometer threshold value in a prospective, multicenter study. The primary objective was to determine the cervicometer cervical length measurement threshold that provides a high negative predictive value for the identification of patients who are highly unlikely to have a transvaginal ultrasound ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b78c4463f6c5baebbba2b4c08ac4e6c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578162,"asset_id":96772553,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578162/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772553"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772553"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772553; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772553]").text(description); $(".js-view-count[data-work-id=96772553]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772553; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772553']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772553, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6b78c4463f6c5baebbba2b4c08ac4e6c" } } $('.js-work-strip[data-work-id=96772553]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772553,"title":"Assessment of a Cervicometer Compared to Transvaginal Ultrasound in Identifying Women with a Short Cervical Length: A Multicenter Study","translated_title":"","metadata":{"abstract":"Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. 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The primary objective was to determine the cervicometer cervical length measurement threshold that provides a high negative predictive value for the identification of patients who are highly unlikely to have a transvaginal ultrasound ...","publication_date":{"day":17,"month":1,"year":2016,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Preterm birth remains a major cause of neonatal morbidity and mortality worldwide. Short cervical length as measured by transvaginal ultrasound in the second trimester represents the single most predictive risk factor for spontaneous preterm birth. Previous studies have addressed, in part, the limitations of transvaginal ultrasound availability by utilizing a cervicometer to screen patients for short cervix, identifying those patients who may not benefit from transvaginal ultrasound cervical length screening. In view of the prior studies indicating that a cervicometer measurement may have a high negative predictive value for a sonographically short cervix, we sought to identify the ideal cervicometer threshold value in a prospective, multicenter study. 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href="https://www.academia.edu/96772552/Programmed_Hyperphagia_in_Offspring_of_Obese_Dams_Altered_Expression_of_Hypothalamic_Nutrient_Sensors_Neurogenic_Factors_and_Epigenetic_Modulators"><img alt="Research paper thumbnail of Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators" class="work-thumbnail" src="https://attachments.academia-assets.com/98578174/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772552/Programmed_Hyperphagia_in_Offspring_of_Obese_Dams_Altered_Expression_of_Hypothalamic_Nutrient_Sensors_Neurogenic_Factors_and_Epigenetic_Modulators">Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators</a></div><div class="wp-workCard_item"><span>Appetite</span><span>, Jan 16, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia. This is remarkably similar to the effects of maternal undernutrition on offspring hyperphagia and obesity. In view of the marked differences in the energy environment of the over and under-nutrition exposures, we studied the expression of select epigenetic modifiers associated with energy imbalance including neurogenic factors and appetite/satiety neuropeptides which are indicative of neurogenic differentiation. HF offspring were exposed to maternal overnutrition (high fat diet; HF) during pregnancy and lactation. We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC). Despite maternal obesity, male offspring born to obese dams had similar body weight at bi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2598dc07dacd20c621bcbdccd99cd32e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578174,"asset_id":96772552,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578174/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772552"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772552"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772552; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772552]").text(description); $(".js-view-count[data-work-id=96772552]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772552; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772552']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772552, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2598dc07dacd20c621bcbdccd99cd32e" } } $('.js-work-strip[data-work-id=96772552]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772552,"title":"Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators","translated_title":"","metadata":{"abstract":"Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia. This is remarkably similar to the effects of maternal undernutrition on offspring hyperphagia and obesity. In view of the marked differences in the energy environment of the over and under-nutrition exposures, we studied the expression of select epigenetic modifiers associated with energy imbalance including neurogenic factors and appetite/satiety neuropeptides which are indicative of neurogenic differentiation. HF offspring were exposed to maternal overnutrition (high fat diet; HF) during pregnancy and lactation. We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC). Despite maternal obesity, male offspring born to obese dams had similar body weight at bi...","publication_date":{"day":16,"month":1,"year":2016,"errors":{}},"publication_name":"Appetite"},"translated_abstract":"Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia. This is remarkably similar to the effects of maternal undernutrition on offspring hyperphagia and obesity. In view of the marked differences in the energy environment of the over and under-nutrition exposures, we studied the expression of select epigenetic modifiers associated with energy imbalance including neurogenic factors and appetite/satiety neuropeptides which are indicative of neurogenic differentiation. HF offspring were exposed to maternal overnutrition (high fat diet; HF) during pregnancy and lactation. We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/96772551/Bisphenol_A_Increases_Neural_Progenitor_Cell_Proliferation_and_Alters_Neurogenesis"><img alt="Research paper thumbnail of Bisphenol A Increases Neural Progenitor Cell Proliferation and Alters Neurogenesis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/96772551/Bisphenol_A_Increases_Neural_Progenitor_Cell_Proliferation_and_Alters_Neurogenesis">Bisphenol A Increases Neural Progenitor Cell Proliferation and Alters Neurogenesis</a></div><div class="wp-workCard_item"><span>Reproductive Sciences</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772551; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772550/Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring"><img alt="Research paper thumbnail of Magnesium sulphate prevents maternal inflammation-induced impairment of learning ability and memory in the rat offspring" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772550/Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring">Magnesium sulphate prevents maternal inflammation-induced impairment of learning ability and memory in the rat offspring</a></div><div class="wp-workCard_item"><span>American journal of obstetrics and gynecology</span><span>, Jan 29, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal chorioamnionitis is associated with newborn neurologic injury. Recent evidence suggests ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal chorioamnionitis is associated with newborn neurologic injury. Recent evidence suggests that maternal administration of magnesium sulphate (MG) may protect fetuses from white matter injury. Previously we demonstrated evidence by magnetic resonance imaging, that MG may prevent maternal inflammation-induced gray matter injury of offspring. Thus, we sought to determine the potential of maternal inflammation to induce fetal neurologic/behavioral deficits, and assess whether maternal MG attenuates these effects. Pregnant rats at day 18 received injections of intraperitoneal lipopolysaccharide (LPS) or saline. Dams were treated with subcutaneous saline/ MG (270 mg/kg followed by 27 mg/kg q20 minutes) for 2 hours before and following LPS/saline injections. Pups were delivered spontaneously. At 1 and 3 months of age, 11-12 offspring of each group (Saline, LPS, MG, LPS-MG) underwent two-way shuttle box avoidance testing. The shuttle box is divided in half and the animal moves betwee...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772550]").text(description); $(".js-view-count[data-work-id=96772550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=96772550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772550,"title":"Magnesium sulphate prevents maternal inflammation-induced impairment of learning ability and memory in the rat offspring","translated_title":"","metadata":{"abstract":"Maternal chorioamnionitis is associated with newborn neurologic injury. Recent evidence suggests that maternal administration of magnesium sulphate (MG) may protect fetuses from white matter injury. Previously we demonstrated evidence by magnetic resonance imaging, that MG may prevent maternal inflammation-induced gray matter injury of offspring. Thus, we sought to determine the potential of maternal inflammation to induce fetal neurologic/behavioral deficits, and assess whether maternal MG attenuates these effects. Pregnant rats at day 18 received injections of intraperitoneal lipopolysaccharide (LPS) or saline. Dams were treated with subcutaneous saline/ MG (270 mg/kg followed by 27 mg/kg q20 minutes) for 2 hours before and following LPS/saline injections. Pups were delivered spontaneously. At 1 and 3 months of age, 11-12 offspring of each group (Saline, LPS, MG, LPS-MG) underwent two-way shuttle box avoidance testing. The shuttle box is divided in half and the animal moves betwee...","publication_date":{"day":29,"month":1,"year":2015,"errors":{}},"publication_name":"American journal of obstetrics and gynecology"},"translated_abstract":"Maternal chorioamnionitis is associated with newborn neurologic injury. Recent evidence suggests that maternal administration of magnesium sulphate (MG) may protect fetuses from white matter injury. Previously we demonstrated evidence by magnetic resonance imaging, that MG may prevent maternal inflammation-induced gray matter injury of offspring. Thus, we sought to determine the potential of maternal inflammation to induce fetal neurologic/behavioral deficits, and assess whether maternal MG attenuates these effects. Pregnant rats at day 18 received injections of intraperitoneal lipopolysaccharide (LPS) or saline. Dams were treated with subcutaneous saline/ MG (270 mg/kg followed by 27 mg/kg q20 minutes) for 2 hours before and following LPS/saline injections. Pups were delivered spontaneously. At 1 and 3 months of age, 11-12 offspring of each group (Saline, LPS, MG, LPS-MG) underwent two-way shuttle box avoidance testing. The shuttle box is divided in half and the animal moves betwee...","internal_url":"https://www.academia.edu/96772550/Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring","translated_internal_url":"","created_at":"2023-02-12T09:38:31.341-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Magnesium_sulphate_prevents_maternal_inflammation_induced_impairment_of_learning_ability_and_memory_in_the_rat_offspring","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":48183,"name":"Lipopolysaccharide","url":"https://www.academia.edu/Documents/in/Lipopolysaccharide"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":335983,"name":"Lipopolysaccharides","url":"https://www.academia.edu/Documents/in/Lipopolysaccharides"},{"id":362036,"name":"White matter","url":"https://www.academia.edu/Documents/in/White_matter"},{"id":439784,"name":"Saline","url":"https://www.academia.edu/Documents/in/Saline"},{"id":522464,"name":"Short Term Memory","url":"https://www.academia.edu/Documents/in/Short_Term_Memory"},{"id":640959,"name":"Chorioamnionitis","url":"https://www.academia.edu/Documents/in/Chorioamnionitis"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"},{"id":987472,"name":"Gestation","url":"https://www.academia.edu/Documents/in/Gestation"},{"id":1279813,"name":"Magnesium Sulfate","url":"https://www.academia.edu/Documents/in/Magnesium_Sulfate"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"},{"id":2451403,"name":"Avoidance Learning","url":"https://www.academia.edu/Documents/in/Avoidance_Learning"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772549"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772549/Adaptive_shut_down_of_EEG_activity_predicts_critical_acidemia_in_the_near_term_ovine_fetus"><img alt="Research paper thumbnail of Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus" class="work-thumbnail" src="https://attachments.academia-assets.com/98578133/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772549/Adaptive_shut_down_of_EEG_activity_predicts_critical_acidemia_in_the_near_term_ovine_fetus">Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus</a></div><div class="wp-workCard_item"><span>Physiological reports</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In fetal sheep, the electrocorticogram (ECOG) recorded directly from the cortex during repetitive...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In fetal sheep, the electrocorticogram (ECOG) recorded directly from the cortex during repetitive heart rate (FHR) decelerations induced by umbilical cord occlusions (UCO) predictably correlates with worsening hypoxic-acidemia. In human fetal monitoring during labor, the equivalent electroencephalogram (EEG) can be recorded noninvasively from the scalp. We tested the hypothesis that combined fetal EEG - FHR monitoring allows for early detection of worsening hypoxic-acidemia similar to that shown for ECOG-FHR monitoring. Near-term fetal sheep (n = 9) were chronically instrumented with arterial and venous catheters, ECG, ECOG, and EEG electrodes and umbilical cord occluder, followed by 4 days of recovery. Repetitive UCOs of 1 min duration and increasing strength (with regard to the degree of reduction in umbilical blood flow) were induced each 2.5 min until pH dropped to &lt;7.00. Repetitive UCOs led to marked acidosis (arterial pH 7.35 ± 0.01 to 7.00 ± 0.03). 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In human fetal monitoring during labor, the equivalent electroencephalogram (EEG) can be recorded noninvasively from the scalp. We tested the hypothesis that combined fetal EEG - FHR monitoring allows for early detection of worsening hypoxic-acidemia similar to that shown for ECOG-FHR monitoring. Near-term fetal sheep (n = 9) were chronically instrumented with arterial and venous catheters, ECG, ECOG, and EEG electrodes and umbilical cord occluder, followed by 4 days of recovery. Repetitive UCOs of 1 min duration and increasing strength (with regard to the degree of reduction in umbilical blood flow) were induced each 2.5 min until pH dropped to \u0026lt;7.00. Repetitive UCOs led to marked acidosis (arterial pH 7.35 ± 0.01 to 7.00 ± 0.03). 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Repetitive UCOs of 1 min duration and increasing strength (with regard to the degree of reduction in umbilical blood flow) were induced each 2.5 min until pH dropped to \u0026lt;7.00. Repetitive UCOs led to marked acidosis (arterial pH 7.35 ± 0.01 to 7.00 ± 0.03). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772548"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772548/Early_life_influences_on_obesity_from_preconception_to_adolescence"><img alt="Research paper thumbnail of Early-life influences on obesity: from preconception to adolescence" class="work-thumbnail" src="https://attachments.academia-assets.com/98578131/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772548/Early_life_influences_on_obesity_from_preconception_to_adolescence">Early-life influences on obesity: from preconception to adolescence</a></div><div class="wp-workCard_item"><span>Annals of the New York Academy of Sciences</span><span>, Jan 2, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The double burden of under- and overnutrition profoundly affects human health globally. According...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff459ce23c6d6b89bd688e719333c130" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578131,"asset_id":96772548,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578131/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772548"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772548"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772548; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772548]").text(description); $(".js-view-count[data-work-id=96772548]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772548; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772548']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772548, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ff459ce23c6d6b89bd688e719333c130" } } $('.js-work-strip[data-work-id=96772548]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772548,"title":"Early-life influences on obesity: from preconception to adolescence","translated_title":"","metadata":{"abstract":"The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.","publication_date":{"day":2,"month":1,"year":2015,"errors":{}},"publication_name":"Annals of the New York Academy of Sciences"},"translated_abstract":"The double burden of under- and overnutrition profoundly affects human health globally. According to the World Health Organization, obesity and diabetes rates have almost doubled worldwide since 1980, and, in 2011, more than 40 million children under 5 years of age were overweight. Ecologic factors, parental genetics and fitness, and the intrauterine environment significantly influence the likelihood of offspring developing the dysmetabolic diathesis of obesity. This report examines the effects of these factors, including preconception, intrauterine and postnatal energy balance affecting programming of transgenerational transmission, and development of chronic diseases later in life-in particular, diabesity and its comorbidities.","internal_url":"https://www.academia.edu/96772548/Early_life_influences_on_obesity_from_preconception_to_adolescence","translated_internal_url":"","created_at":"2023-02-12T09:38:31.081-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":206331257,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98578131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578131/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/98578131/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_life_influences_on_obesity_from_pr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578131/ptpmcrender-libre.pdf?1676224575=\u0026response-content-disposition=attachment%3B+filename%3DEarly_life_influences_on_obesity_from_pr.pdf\u0026Expires=1733240517\u0026Signature=g7cUsQUD08RbHR8V-tnrrYaOYqLFpfAlIOLSXkt4xPr3XbQQVNVcEVQ1yue0cmkZRatf7tuamh4LhYVCcCtVVOgyaBDwQmdAtqcLinylHQMMlYwgpbxKn~NSQoOI5p1UM9gQTEoLGQBitG9ULGggTuTQhsQhTPkgw8dgB-0-g9FN0pULYWlCJG9Fq9I0A~k58OaB9WZb92Kf2SQ5H1Fn6FIR6SA-GmxEDhQIP0uaNVWx5KIiKIbXhtVPidondEppjuf4Gukrg3MKcr4BntOl7V4wwkMp~SSNSNlT7bzjtAPTukjtdO~H38inJd7WNzYYNYRZfyBRXstFpZcXn5UO4w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Early_life_influences_on_obesity_from_preconception_to_adolescence","translated_slug":"","page_count":42,"language":"en","content_type":"Work","owner":{"id":206331257,"first_name":"Michael","middle_initials":null,"last_name":"Ross","page_name":"MichaelRoss141","domain_name":"independent","created_at":"2021-10-21T14:42:03.831-07:00","display_name":"Michael Ross","url":"https://independent.academia.edu/MichaelRoss141"},"attachments":[{"id":98578131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98578131/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/98578131/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_life_influences_on_obesity_from_pr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98578131/ptpmcrender-libre.pdf?1676224575=\u0026response-content-disposition=attachment%3B+filename%3DEarly_life_influences_on_obesity_from_pr.pdf\u0026Expires=1733240517\u0026Signature=g7cUsQUD08RbHR8V-tnrrYaOYqLFpfAlIOLSXkt4xPr3XbQQVNVcEVQ1yue0cmkZRatf7tuamh4LhYVCcCtVVOgyaBDwQmdAtqcLinylHQMMlYwgpbxKn~NSQoOI5p1UM9gQTEoLGQBitG9ULGggTuTQhsQhTPkgw8dgB-0-g9FN0pULYWlCJG9Fq9I0A~k58OaB9WZb92Kf2SQ5H1Fn6FIR6SA-GmxEDhQIP0uaNVWx5KIiKIbXhtVPidondEppjuf4Gukrg3MKcr4BntOl7V4wwkMp~SSNSNlT7bzjtAPTukjtdO~H38inJd7WNzYYNYRZfyBRXstFpZcXn5UO4w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1048,"name":"Health Behavior","url":"https://www.academia.edu/Documents/in/Health_Behavior"},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity"},{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism"},{"id":63375,"name":"Overweight","url":"https://www.academia.edu/Documents/in/Overweight"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise"},{"id":290613,"name":"Diathesis","url":"https://www.academia.edu/Documents/in/Diathesis"},{"id":369093,"name":"Food habits","url":"https://www.academia.edu/Documents/in/Food_habits"},{"id":443581,"name":"Breast feeding","url":"https://www.academia.edu/Documents/in/Breast_feeding"},{"id":546430,"name":"Food Preferences","url":"https://www.academia.edu/Documents/in/Food_Preferences"},{"id":978192,"name":"Offspring","url":"https://www.academia.edu/Documents/in/Offspring"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96772547"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772547/Intrauterine_growth_restriction_increases_the_preference_for_palatable_foods_and_affects_sensitivity_to_food_rewards_in_male_and_female_adult_rats"><img alt="Research paper thumbnail of Intrauterine growth restriction increases the preference for palatable foods and affects sensitivity to food rewards in male and female adult rats" class="work-thumbnail" src="https://attachments.academia-assets.com/98578167/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772547/Intrauterine_growth_restriction_increases_the_preference_for_palatable_foods_and_affects_sensitivity_to_food_rewards_in_male_and_female_adult_rats">Intrauterine growth restriction increases the preference for palatable foods and affects sensitivity to food rewards in male and female adult rats</a></div><div class="wp-workCard_item"><span>Brain Research</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="87c81697ea5639ff4fa59273efc92dc9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578167,"asset_id":96772547,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578167/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772547"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772547"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772547; 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In this study, we compared food preferences, the response to food rewards, and the role of the mesolimbic dopaminergic system in feeding behavior, between IUGR and control rats. Time-mated pregnant Sprague-Dawley rats were randomly allocated to a control group (standard chow ad libitum) or a 50% food restriction (FR) group, which received 50% of the control dams' habitual intake. These diets were provided from gestation day 10 to the 21st day of lactation. Within 24 h of birth, pups were cross-fostered and divided into four groups: Adlib/Adlib, FR/Adlib, FR/FR, Adlib/FR. Standard chow consumption was compared between all groups. Food preferences, conditioned place preference to a palatable diet, and the levels of tyrosine hydroxylase (TH) phosphorylation and D2 receptors in the nucleus accumbens were analyzed and compared between the two groups of interest: Adlib/Adlib (control) and FR/Adlib (exposed to growth restriction during the fetal period only). IUGR adult rats had a stronger preference for palatable foods, but showed less conditioned place preference to a palatable diet than controls. D2 receptors levels were lower in IUGR rats. At baseline, TH and pTH levels were higher in FR/Adlib than control males. Measurements taken after exposure to sweet foods revealed higher levels of TH and pTH in FR/Adlib than control females. These data showed","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Brain 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96772546/Maternal_High_Fat_Diet_Programs_Rat_Offspring_Liver_Fatty_Acid_Metabolism"><img alt="Research paper thumbnail of Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism" class="work-thumbnail" src="https://attachments.academia-assets.com/98578146/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96772546/Maternal_High_Fat_Diet_Programs_Rat_Offspring_Liver_Fatty_Acid_Metabolism">Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism</a></div><div class="wp-workCard_item"><span>Lipids</span><span>, Jan 22, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8bda4f81a8498e6fb548c4cf84fa83c1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98578146,"asset_id":96772546,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98578146/download_file?st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&st=MTczMzIzNjkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96772546"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96772546"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96772546; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96772546]").text(description); $(".js-view-count[data-work-id=96772546]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96772546; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96772546']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96772546, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8bda4f81a8498e6fb548c4cf84fa83c1" } } $('.js-work-strip[data-work-id=96772546]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96772546,"title":"Maternal High-Fat-Diet Programs Rat Offspring Liver Fatty Acid Metabolism","translated_title":"","metadata":{"abstract":"In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions w...","publication_date":{"day":22,"month":1,"year":2015,"errors":{}},"publication_name":"Lipids"},"translated_abstract":"In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. 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