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Study Finds Regular Aspirin Use Associated with Greatest Reduction in Colorectal Cancer Among Those Most at Risk | Mass General Brigham

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href="/en/research-and-innovation/participate-in-research" target="_self"> <span>Participate in Research</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/patient-visitor-information/videos" target="_self"> <span>Educational Resources</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Visitor Information </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/find-a-location" target="_self"> <span>Find a Location</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/patient-visitor-information/planning-your-visit/shuttles" target="_self"> <span>Shuttles</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/patient-visitor-information/planning-your-visit/visitor-policy" target="_self"> <span>Visitor Policies</span> </a> </li> </ul> </li> </ul> </div> </li> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_hospitalsservicesspecialties" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Hospitals, Services &amp; Specialties <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_hospitalsservicesspecialties" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/patient-care/services-and-specialties" target="_self"> <span>Hospitals, Services &amp; Specialties</span> </a> </div> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Services &amp; Specialties </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/cancer" target="_self"> <span>We’re One Against Cancer</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/primary-care" target="_self"> <span>Primary Care</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/urgent-care" target="_self"> <span>Urgent Care</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/virtual-care" target="_self"> <span>Virtual Care</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/healthcare-at-home" target="_self"> <span>Healthcare at Home</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/heart" target="_self"> <span>Heart Care</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/community-physicians" target="_self"> <span>Mass General Brigham Community Physicians</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/rehabilitation" target="_self"> <span>Rehabilitation</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/sports-medicine" target="_self"> <span>Sports Medicine</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Hospitals </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/locations.location=Hospital" target="_self"> <span>Hospital Locations</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/services-and-specialties/find-a-location/our-hospitals" target="_self"> <span>Information About Our Hospitals</span> </a> </li> </ul> </li> </ul> </div> </li> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_virtualcare" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Virtual Care <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_virtualcare" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/patient-care/virtual-care" target="_self"> <span>Virtual Care</span> </a> </div> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Our Virtual Care Options </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/virtual-care/virtual-urgent-care" target="_self"> <span>Virtual Urgent Care</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/virtual-care/virtual-visits" target="_self"> <span>Virtual Visits for Primary &amp; Specialty Care</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/patient-care/virtual-care/online-second-opinions" target="_self"> <span>Online Second Opinions</span> </a> </li> </ul> </li> </ul> </div> </li> </ul> <ul class="cmp-global-header-main-nav-item-list main-nav-item-inactive" style="display: none"> <li> <a class="cmp-global-header-main-nav-item no-children mainNavigation-inactive internal" href="/en/research-and-innovation/participate-in-research" target="_self"> <span>Participate in Research</span> </a> </li> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_centersprograms" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Centers &amp; Programs <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_centersprograms" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/research-and-innovation/centers-and-programs" target="_self"> <span>Research Centers &amp; Programs</span> </a> </div> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/hospital-research-institutes" target="_self"> <span>Hospital Research Institutes</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/artificial-intelligence" target="_self"> <span>Artificial Intelligence</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/gene-cell-therapy" target="_self"> <span>Gene and Cell Therapy Institute</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/personalized-medicine" target="_self"> <span>Personalized Medicine</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/population-health" target="_self"> <span>Population Health</span> </a> </li> </ul> </li> </ul> </div> </li> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_innovation" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Innovation <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_innovation" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/research-and-innovation/innovation" target="_self"> <span> Mass General Brigham Innovation</span> </a> </div> <a href="/en/research-and-innovation/innovation/contact" target="_self" class="cmp-global-header-main-nav-expanded-button internal"> <span>Contact us</span> </a> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> About Innovation </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/innovation/about" target="_self"> <span>About</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/innovation/about/team" target="_self"> <span>Team</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/innovation/news" target="_self"> <span>News</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> For Industry </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/innovation/venture-capital-and-investments" target="_self"> <span>Venture Capital and Investments</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="https://worldmedicalinnovation.org/" target="_blank"> <span>World Medical Innovation Forum</span> <span class="sr-only"> (opens link in new tab)</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/innovation/for-industry/featured-licensing" target="_self"> <span>Featured Licensing Opportunities</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> For Innovators </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/innovation/for-innovators/commercialization" target="_self"> <span>Commercialization Guide for Innovators</span> </a> </li> </ul> </li> </ul> </div> </li> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_researcherscollaborators" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Researchers &amp; Collaborators <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_researcherscollaborators" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/research-and-innovation/for-researchers-and-collaborators" target="_self"> <span>For Researchers &amp; Collaborators</span> </a> </div> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/information-for-researchers" target="_self"> <span>Information for Researchers</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/compliance-office" target="_self"> <span>Compliance Office</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/research-cores" target="_self"> <span>Research Cores</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/clinical-trials-office" target="_self"> <span>Clinical Trials</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/advisory-services" target="_self"> <span>Advisory Services</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Featured Research </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/breakthroughs" target="_self"> <span>Two Centuries of Breakthroughs</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="https://advances.massgeneral.org/" target="_blank"> <span>Advances in Motion</span> <span class="sr-only"> (opens link in new tab)</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="https://www.brighamhealthonamission.org/" target="_blank"> <span>Brigham on a Mission</span> <span class="sr-only"> (opens link in new tab)</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/centers-and-programs/gene-cell-therapy" target="_self"> <span>Gene and Cell Therapy Institute</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Research News </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/alzheimers" target="_self"> <span>Alzheimer&#39;s Disease</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/artificial-intelligence" target="_self"> <span>Artificial Intelligence</span> </a> </li> </ul> </li> </ul> </div> </li> </ul> <ul class="cmp-global-header-main-nav-item-list main-nav-item-inactive" style="display: none"> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_graduatemedicaleducation" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Graduate Medical Education <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_graduatemedicaleducation" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/education-and-training/graduate-medical-education" target="_self"> <span>Graduate Medical Education</span> </a> </div> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Residency &amp; fellowship programs </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/brigham-and-womens-hospital" target="_self"> <span>Brigham and Women&#39;s Hospital</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/massachusetts-general-hospital" target="_self"> <span>Massachusetts General Hospital</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/mass-eye-and-ear" target="_self"> <span>Mass Eye and Ear</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/newton-wellesley-hospital" target="_self"> <span>Newton-Wellesley Hospital</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/salem-hospital" target="_self"> <span>Salem Hospital</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/integrated-programs" target="_self"> <span>Integrated Mass General Brigham Programs</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> Centers of Expertise </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/global-community-health" target="_self"> <span>Global &amp; Community Health</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/health-policy-and-management" target="_self"> <span>Health Policy &amp; Management</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/healthcare-quality-patient-safety" target="_self"> <span>Healthcare Quality &amp; Patient Safey</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/medical-education" target="_self"> <span>Medical Education</span> </a> </li> </ul> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> For trainees </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/prospective" target="_self"> <span>Prospective trainees</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/incoming" target="_self"> <span>Incoming trainees</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/current" target="_self"> <span>Current trainees</span> </a> </li> </ul> </li> </ul> </div> </li> <li> <a class="cmp-global-header-main-nav-item no-children mainNavigation-inactive internal" href="/en/education-and-training/continuing-professional-development" target="_self"> <span>Continuing Professional Development</span> </a> </li> <li class="cmp-global-header-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="id_otherlearningopportunities" class="cmp-global-header-main-nav-item mainNavigation-inactive"> Other Learning Opportunities <div class="cmp-global-header-main-nav-expand-icon"></div> <div class="cmp-global-header-main-nav-collapse-icon"></div> </button> <div class="cmp-global-header-main-nav-expanded-wrapper"> <ul id="id_otherlearningopportunities" class="cmp-global-header-main-nav-expanded" style="display: none"> <li class="cmp-global-header-main-nav-expanded-column-one"> <div class="cmp-global-header-main-nav-expanded-title"> <a href="/en/education-and-training/learning-opportunities" target="_self"> <span>Other Learning Opportunities</span> </a> </div> </li> <li> <ul class="cmp-global-header-main-nav-expanded-children-wrapper"> <li class="cmp-global-header-main-nav-expanded-childHeader"> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/mgh-institute-of-health-professions" target="_self"> <span>MGH Institute of Health Professions</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/learning-opportunities/internships" target="_self"> <span>Internships</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-subChildren"> <a href="/en/education-and-training/learning-opportunities/medical-laboratory-science-training-program" target="_self"> <span>Medical Lab Science Training 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class="internal"> <span>Shuttles</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/patient-care/patient-visitor-information/planning-your-visit/visitor-policy" target="_self" class="internal"> <span>Visitor Policies</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-expanded-button-wrapper"> <a href="/en/patient-care/get-care" class="cmp-global-header-mobile-main-nav-expanded-button internal" target="_self"> <span>Find Care</span> </a> </li> </ul> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="hospitalsservicesspecialties-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Hospitals, Services &amp; Specialties </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span 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aria-controls="innovation-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Innovation </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="innovation-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="innovation-overview" href="/en/research-and-innovation/innovation" target="_self">Overview</a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> About Innovation </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/innovation/about" target="_self" class="internal"> <span>About</span> </a> </li> <li 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class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/innovation/for-industry/featured-licensing" target="_self" class="internal"> <span>Featured Licensing Opportunities</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> For Innovators </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/innovation/for-innovators/commercialization" target="_self" class="internal"> <span>Commercialization Guide for Innovators</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-expanded-button-wrapper"> <a href="/en/research-and-innovation/innovation/contact" class="cmp-global-header-mobile-main-nav-expanded-button internal" target="_self"> <span>Contact us</span> </a> </li> </ul> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="researcherscollaborators-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Researchers &amp; Collaborators </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="researcherscollaborators-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="researcherscollaborators-overview" href="/en/research-and-innovation/for-researchers-and-collaborators" target="_self">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/information-for-researchers" target="_self" class="internal"> <span>Information for Researchers</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/compliance-office" target="_self" class="internal"> <span>Compliance Office</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/research-cores" target="_self" class="internal"> <span>Research Cores</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/centers-and-programs/clinical-trials-office" target="_self" class="internal"> <span>Clinical Trials</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/advisory-services" target="_self" class="internal"> <span>Advisory Services</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> Featured Research </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/breakthroughs" target="_self" class="internal"> <span>Two Centuries of Breakthroughs</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="https://advances.massgeneral.org/" target="_blank" class="internal"> <span>Advances in Motion</span> <span class="sr-only"> (opens link in new tab)</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="https://www.brighamhealthonamission.org/" target="_blank" class="internal"> <span>Brigham on a Mission</span> <span class="sr-only"> (opens link in new tab)</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/centers-and-programs/gene-cell-therapy" target="_self" class="internal"> <span>Gene and Cell Therapy Institute</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> Research News </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/alzheimers" target="_self" class="internal"> <span>Alzheimer&#39;s Disease</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/research-and-innovation/for-researchers-and-collaborators/artificial-intelligence" target="_self" class="internal"> <span>Artificial Intelligence</span> </a> </li> </ul> </li> </ul> </div> </li> <li class="cmp-global-header-mobile-section-nav-header"> <button type="button" aria-expanded="false" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-section-nav-header-button" aria-controls="educationtraining-menu"> <span class="cmp-global-header-mobile-section-nav-item"> Education &amp; Training </span> <span class="cmp-global-header-mobile-section-nav-expand-icon"></span> <span 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<ul id="graduatemedicaleducation-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="graduatemedicaleducation-overview" href="/en/education-and-training/graduate-medical-education" target="_self">Overview</a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> Residency &amp; fellowship programs </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/brigham-and-womens-hospital" target="_self" class="internal"> <span>Brigham and Women&#39;s Hospital</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/massachusetts-general-hospital" target="_self" class="internal"> <span>Massachusetts General Hospital</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/mass-eye-and-ear" target="_self" class="internal"> <span>Mass Eye and Ear</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/newton-wellesley-hospital" target="_self" class="internal"> <span>Newton-Wellesley Hospital</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/salem-hospital" target="_self" class="internal"> <span>Salem Hospital</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/residencies-and-fellowships/integrated-programs" target="_self" class="internal"> <span>Integrated Mass General Brigham Programs</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> Centers of Expertise </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/global-community-health" target="_self" class="internal"> <span>Global &amp; Community Health</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/health-policy-and-management" target="_self" class="internal"> <span>Health Policy &amp; Management</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/healthcare-quality-patient-safety" target="_self" class="internal"> <span>Healthcare Quality &amp; Patient Safey</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/centers-of-expertise/medical-education" target="_self" class="internal"> <span>Medical Education</span> </a> </li> <li class="cmp-global-header-main-nav-expanded-childHeader"> For trainees </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/prospective" target="_self" class="internal"> <span>Prospective trainees</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/incoming" target="_self" class="internal"> <span>Incoming trainees</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/graduate-medical-education/for-trainees/current" target="_self" class="internal"> <span>Current trainees</span> </a> </li> </ul> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/continuing-professional-development" class="internal"> <span>Continuing Professional Development</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="otherlearningopportunities-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Other Learning Opportunities </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="otherlearningopportunities-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="otherlearningopportunities-overview" href="/en/education-and-training/learning-opportunities" target="_self">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/mgh-institute-of-health-professions" target="_self" class="internal"> <span>MGH Institute of Health Professions</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/learning-opportunities/internships" target="_self" class="internal"> <span>Internships</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/learning-opportunities/medical-laboratory-science-training-program" target="_self" class="internal"> <span>Medical Lab Science Training Program</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/learning-opportunities/workforce-development" target="_self" class="internal"> <span>Mass General Brigham Workforce Development</span> </a> </li> </ul> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="oureducationalcommitment-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Our Educational Commitment </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="oureducationalcommitment-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="oureducationalcommitment-overview" href="/en/education-and-training/our-educational-commitment" target="_self">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/education-and-training/alumni-association" target="_self" class="internal"> <span>Alumni Association</span> </a> </li> </ul> </li> </ul> </div> </li> <li class="cmp-global-header-mobile-section-nav-header"> <button type="button" aria-expanded="false" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-section-nav-header-button" aria-controls="about-menu"> <span class="cmp-global-header-mobile-section-nav-item"> About </span> <span class="cmp-global-header-mobile-section-nav-expand-icon"></span> <span class="cmp-global-header-mobile-section-nav-collapse-icon" style="display: none"></span> </button> <div class="cmp-global-header-mobile-main-nav-wrapper" style="display: none" id="about-menu"> <ul class="cmp-global-header-mobile-main-nav-list-wrapper"> <li class="cmp-global-header-main-nav-expanded-sectionlink"> <a href="/en/about" id="about-overview" aria-labelledby="about-menu-trigger about-overview">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="advancingcare-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Advancing Care </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="advancingcare-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="advancingcare-overview" href="/en/about/advancing-care" target="_self">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/advancing-care/integrated-healthcare-system" target="_self" class="internal"> <span>Integrated Healthcare System</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/patient-care/patient-visitor-information/quality-of-care" target="_self" class="internal"> <span>Quality of Care</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/advancing-care/health-equity-community-health" target="_self" class="internal"> <span>Health Equity &amp; Community Health</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/members-affiliations" target="_self" class="internal"> <span>Members and Affiliates</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/advancing-care/history" target="_self" class="internal"> <span>History</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/leadership-and-governance" target="_self" class="internal"> <span>Leadership</span> </a> </li> </ul> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="commitmenttodiversityequityandinclusion-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Commitment to Diversity, Equity, and Inclusion </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="commitmenttodiversityequityandinclusion-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="commitmenttodiversityequityandinclusion-overview" href="/en/about/diversity-equity-and-inclusion" target="_self">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/diversity-equity-and-inclusion/united-against-racism" target="_self" class="internal"> <span>United Against Racism</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/diversity-equity-and-inclusion/employee-resource-groups" target="_self" class="internal"> <span>Employee Resource Groups</span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/diversity-equity-and-inclusion/accessibility" target="_self" class="internal"> <span>Accessibility</span> </a> </li> </ul> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/newsroom" class="internal"> <span>Newsroom </span> </a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper"> <button type="button" aria-expanded="false" aria-controls="careers-submenu" class="cmp-global-mobile-nav-toggle-btn cmp-global-header-mobile-main-nav-item-header-wrapper"> <span class="cmp-global-header-mobile-main-nav-item"> Careers </span> <span class="cmp-global-header-mobile-main-nav-expand-icon"></span> <span class="cmp-global-header-mobile-main-nav-collapse-icon" style="display: none"></span> </button> <ul id="careers-submenu" class="cmp-global-header-mobile-main-nav-children-wrapper" style="display: none"> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a id="careers-overview" href="/en/about/careers" target="_self">Overview</a> </li> <li class="cmp-global-header-mobile-main-nav-item-wrapper-main-nav-link"> <a href="/en/about/careers/benefits" target="_self" class="internal"> <span>Benefits</span> </a> </li> <li 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class="cmp-dynamic-alert-container" data-service-url="/content/mgb-global/global/en/about/newsroom/press-releases/study-finds-regular-aspirin-use-associated-with-greatest-reduction-in-colorectal-cancer-among-those-most-at-risk.dynamic-alerts.json"></div> </div> </div> <div class="container responsivegrid aem-GridColumn aem-GridColumn--default--12"> <div id="container-1fd32ef307" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <div class="article-hero aem-GridColumn aem-GridColumn--default--12"><div> <div class="cmp-article-hero"> <h1 class="cmp-article-hero-title"> Study Finds Regular Aspirin Use Associated with Greatest Reduction in Colorectal Cancer Among Those Most at Risk </h1> <div class="cmp-article-hero-info-wrapper"> <div class="cmp-article-hero-time-wrapper"> <div class="cmp-article-hero-date"><time datetime="2024-08-01">Aug 1, 2024</time> </div> </div> </div> <div class="cmp-article-hero-row"> <div class="cmp-article-hero-tags" role="region" aria-label="related topic tags"> <ul class="cmp-article-hero-tags-item-wrapper"> <li class="cmp-article-hero-tags-item"><a href="https://www.massgeneralbrigham.org/en/about/newsroom.topic&#61;Research">Research</a></li> <li class="cmp-article-hero-tags-item"><a href="https://www.massgeneralbrigham.org/en/about/newsroom.topic&#61;Cancer">Cancer</a></li> </ul> </div> <div class="cmp-article-hero-social-links" role="region" aria-label="share this article"> <ul class="cmp-article-hero-social-links-wrapper"> <li> <a href="#" class="cmp-article-hero-facebook"><span class="sr-only">share on facebook</span> <div class="cmp-article-hero-facebook-icon"></div> </a> </li> <li> <a href="#" class="cmp-article-hero-linkedin"><span class="sr-only">share on linkedIn</span> <div class="cmp-article-hero-linkedin-icon"></div> </a> </li> <li> <a href="#" class="cmp-article-hero-x-twitter"><span class="sr-only">share on X, formerly known as Twitter</span> <div class="cmp-article-hero-x-twitter-icon"></div> </a> </li> <li> <a href="#" class="cmp-article-hero-mail"><span class="sr-only">share by email</span> <div class="cmp-article-hero-mail-icon"></div> </a> </li> <li> <button class="cmp-article-hero-print"><span class="sr-only">print article</span> <div class="cmp-article-hero-print-icon"></div> </button> </li> </ul> </div> </div> </div> </div> </div> <div class="container responsivegrid cmp-container-1440-gutters aem-GridColumn aem-GridColumn--default--12"> <div id="container-487fda936e" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="vertical-spacer aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-vertical-spacer cmp-space-small" aria-hidden="true"></div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div data-cmp-data-layer="{&#34;text-81b9e595fa&#34;:{&#34;@type&#34;:&#34;aem-mgb/components/text&#34;,&#34;repo:modifyDate&#34;:&#34;2024-08-01T15:00:46Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>&lt;b>Among men and women followed for more than 30 years, those with less healthy lifestyles had the greatest benefit from regular aspirin use, according to a Mass General Brigham-led study&lt;/b>&lt;/p>\r\n&lt;hr>\r\n\r\n&lt;p>&lt;b>KEY TAKEAWAYS&lt;/b>&lt;/p>\r\n&lt;ul>\r\n&lt;li>In a study of more than 100,000 people, Mass General Brigham researchers found that people with a less healthy lifestyle (higher BMI, greater smoking, greater alcohol consumption, less physical activity, poorer diet quality) had a greater reduction in risk of colorectal cancer associated with aspirin use, compared to participants with a healthier lifestyle.&lt;/li>\r\n&lt;/ul>\r\n&lt;ul>\r\n&lt;li>Participants with a healthier lifestyle had a lower baseline risk of colorectal cancer, and their benefit was less pronounced.&amp;nbsp;&lt;/li>\r\n&lt;/ul>\r\n&lt;ul>\r\n&lt;li>The study’s findings could encourage a more nuanced approach to preventive aspirin use.&lt;/li>\r\n&lt;/ul>\r\n&lt;hr>\r\n\r\n&lt;p>Regular aspirin may help lower risk of colorectal cancer in people with greater lifestyle-related risk factors for the disease, according to a study led by researchers at Mass General Brigham. The study, published in &lt;a href=\&#34;https://jamanetwork.com/journals/jama/fullarticle/10.1001/jamaoncol.2024.2503?utm_campaign=articlePDF%26utm_medium=articlePDFlink%26utm_source=articlePDF%26utm_content=jamaoncol.2024.2503\&#34; target=\&#34;_blank\&#34;>&lt;i>JAMA Oncology&lt;/i>&lt;/a>, could encourage a more nuanced approach to preventive aspirin use.&lt;br>\r\n&lt;/p>\r\n&lt;p>“We sought to identify individuals who are more likely to benefit from aspirin to facilitate more personalized prevention strategies,” said co-senior author Andrew Chan, MD, MPH, &lt;a href=\&#34;https://www.mghcteu.org/\&#34; target=\&#34;_blank\&#34;>Director of Epidemiology&lt;/a> for the Mass General Cancer Center and &lt;a href=\&#34;https://www.massgeneral.org/cancer-center/treatments-and-services/gastrointestinal-cancers/young-adult-colorectal-cancer/team\&#34; target=\&#34;_blank\&#34;>gastroenterology Director of the Center for Young Adult Colorectal Cancer&lt;/a> at Massachusetts General Hospital (MGH). Colorectal cancer is the &lt;a href=\&#34;https://seer.cancer.gov/statfacts/html/colorect.html\&#34; target=\&#34;_blank\&#34;>second-leading cause of cancer death&lt;/a> in the United States, according to the National Cancer Institute.&lt;/p>\r\n&lt;p>The U.S. Preventive Services Task Force previously recommended daily low-dose aspirin to prevent cardiovascular events and colorectal cancer in all adults ages 50 to 59 (the highest risk age group for colorectal cancer). In 2016, they withdrew the recommendation in part due to concerns about aspirin increasing the risk of gastrointestinal bleeding.&lt;/p>\r\n&lt;p>For the study, researchers analyzed the health data from 107,655 participants from the Nurses’ Health Study and Health Professionals Follow-Up Study. They compared the colorectal cancer rates in those who took aspirin regularly with those who did not take aspirin regularly. Regular aspirin use was defined as either two or more standard dose (325 mg) tablets per week or daily low-dose (81 mg) aspirin.&lt;/p>\r\n&lt;p>Study participants were followed starting from an average age of 49.4 years. Those who regularly took aspirin had a colorectal cancer 10-year cumulative incidence of 1.98 percent, compared to 2.95 percent among those who did not take aspirin.&lt;/p>\r\n&lt;p>The benefit of aspirin was largest among those with the unhealthiest lifestyles. Those with the lowest healthy lifestyle scores (unhealthiest) had a 3.4 percent chance of getting colorectal cancer if they did not take regular aspirin and a 2.12 percent chance of getting colorectal cancer if they took aspirin regularly. By contrast, in those with the highest healthy lifestyle scores (healthiest), the colorectal cancer rates were 1.5 percent in regular aspirin-taking group and 1.6% in the non-regular aspirin group. &lt;a name=\&#34;_Hlk173157308\&#34; id=\&#34;_Hlk173157308\&#34;>&lt;/a>This means that in the least healthy group, treating 78 patients with aspirin would prevent one case of colorectal cancer over a 10-year period, while it would take treating 909 patients to prevent one case for the healthiest group. Lifestyle scores were calculated based on body mass index, frequency of cigarette and alcohol use, physical activity, and adherence to a high-quality diet.&lt;/p>\r\n&lt;p>“Our results show that aspirin can proportionally lower the markedly elevated risk in those with multiple risk factors for colorectal cancer,” said Daniel Sikavi, MD, lead author of the paper and a gastroenterologist at MGH. “In contrast, those with&amp;nbsp;a&amp;nbsp;healthier lifestyle have&amp;nbsp;a&amp;nbsp;lower baseline risk of colorectal cancer, and, therefore, their benefit from aspirin was still evident, albeit less pronounced.”&lt;/p>\r\n&lt;p>One outcome of the study could be that “healthcare providers might more strongly consider recommending aspirin to patients who have less healthy lifestyles,” said co-senior author Long H. Nguyen, MD, MS, a&amp;nbsp;physician investigator in the Clinical and Translational Epidemiology Unit and Division of Gastroenterology at MGH and a Chen Institute Department of Medicine Transformative Scholar at MGH.&lt;/p>\r\n&lt;p>While the study included those who took regular standard-dose (325-mg) aspirin two times a week in the regular-aspirin using category, Sikavi noted that “based on prior studies, the best evidence supports daily low-dose&amp;nbsp;(81-mg) aspirin&amp;nbsp;for prevention.”&lt;/p>\r\n&lt;p>Previous studies have found evidence to suggest aspirin can reduce the production of pro-inflammatory proteins, known as prostaglandins, that can promote the development of cancer. Aspirin may also block signaling pathways that cause cells to grow out of control, influence the immune response against cancer cells, and block the development of blood vessels that supply nutrients to cancer cells. “Aspirin likely prevents colorectal cancer through&amp;nbsp;multiple mechanisms,” Chan said.&lt;/p>\r\n&lt;p>The study did not assess potential side effects of daily aspirin use, such as bleeding. In addition, while the study tried to control for a wide range of risk factors for colorectal cancer, in comparing non-aspirin and aspirin-taking groups with the same level of risk factors, because this was an observational study, it is possible there may have been additional factors that influenced the findings.&lt;/p>\r\n&lt;hr>\r\n\r\n&lt;p>&lt;b>Authorship: &lt;/b>In addition to Sikavi, Chan, and Nguyen, Mass General Brigham authors include Wenjie Ma (MGH), David A. Drew (MGH), Shuji Ogino (BWH), Edward L. Giovannucci (BWH), and Mingyang Song (MGH). Additional authors include Kai Wang and Yin Cao.&lt;b>&lt;/b>&lt;/p>\r\n&lt;p>&lt;b>Disclosures: &lt;/b>Chan reported receiving personal fees from Boehringer Ingelheim, Pfizer Inc, and Freenome outside the submitted work.&lt;b>&lt;/b>&lt;/p>\r\n&lt;p>&lt;b>Funding: &lt;/b>The research was supported by grants for the Nurses&#39; Health study and the Health Professionals Follow-Up Study from the National Cancer Institute and the American Cancer Society.&lt;b>&lt;/b>&lt;/p>\r\n&lt;p>&lt;b>Paper cited:&lt;/b> Sikavi, D &lt;i>et al.&lt;/i> “Aspirin Use and Incidence of Colorectal Cancer According to Lifestyle Risk” &lt;i>JAMA Oncology&lt;/i> DOI: 10.1001/jamaoncol.2024.2503&lt;/p>\r\n&#34;}}" id="text-81b9e595fa" class="cmp-text"> <p><b>Among men and women followed for more than 30 years, those with less healthy lifestyles had the greatest benefit from regular aspirin use, according to a Mass General Brigham-led study</b></p> <hr> <p><b>KEY TAKEAWAYS</b></p> <ul> <li>In a study of more than 100,000 people, Mass General Brigham researchers found that people with a less healthy lifestyle (higher BMI, greater smoking, greater alcohol consumption, less physical activity, poorer diet quality) had a greater reduction in risk of colorectal cancer associated with aspirin use, compared to participants with a healthier lifestyle.</li> </ul> <ul> <li>Participants with a healthier lifestyle had a lower baseline risk of colorectal cancer, and their benefit was less pronounced.&nbsp;</li> </ul> <ul> <li>The study’s findings could encourage a more nuanced approach to preventive aspirin use.</li> </ul> <hr> <p>Regular aspirin may help lower risk of colorectal cancer in people with greater lifestyle-related risk factors for the disease, according to a study led by researchers at Mass General Brigham. The study, published in <a href="https://jamanetwork.com/journals/jama/fullarticle/10.1001/jamaoncol.2024.2503?utm_campaign=articlePDF%26utm_medium=articlePDFlink%26utm_source=articlePDF%26utm_content=jamaoncol.2024.2503" target="_blank"><i>JAMA Oncology</i></a>, could encourage a more nuanced approach to preventive aspirin use.<br> </p> <p>“We sought to identify individuals who are more likely to benefit from aspirin to facilitate more personalized prevention strategies,” said co-senior author Andrew Chan, MD, MPH, <a href="https://www.mghcteu.org/" target="_blank">Director of Epidemiology</a> for the Mass General Cancer Center and <a href="https://www.massgeneral.org/cancer-center/treatments-and-services/gastrointestinal-cancers/young-adult-colorectal-cancer/team" target="_blank">gastroenterology Director of the Center for Young Adult Colorectal Cancer</a> at Massachusetts General Hospital (MGH). Colorectal cancer is the <a href="https://seer.cancer.gov/statfacts/html/colorect.html" target="_blank">second-leading cause of cancer death</a> in the United States, according to the National Cancer Institute.</p> <p>The U.S. Preventive Services Task Force previously recommended daily low-dose aspirin to prevent cardiovascular events and colorectal cancer in all adults ages 50 to 59 (the highest risk age group for colorectal cancer). In 2016, they withdrew the recommendation in part due to concerns about aspirin increasing the risk of gastrointestinal bleeding.</p> <p>For the study, researchers analyzed the health data from 107,655 participants from the Nurses’ Health Study and Health Professionals Follow-Up Study. They compared the colorectal cancer rates in those who took aspirin regularly with those who did not take aspirin regularly. Regular aspirin use was defined as either two or more standard dose (325 mg) tablets per week or daily low-dose (81 mg) aspirin.</p> <p>Study participants were followed starting from an average age of 49.4 years. Those who regularly took aspirin had a colorectal cancer 10-year cumulative incidence of 1.98 percent, compared to 2.95 percent among those who did not take aspirin.</p> <p>The benefit of aspirin was largest among those with the unhealthiest lifestyles. Those with the lowest healthy lifestyle scores (unhealthiest) had a 3.4 percent chance of getting colorectal cancer if they did not take regular aspirin and a 2.12 percent chance of getting colorectal cancer if they took aspirin regularly. By contrast, in those with the highest healthy lifestyle scores (healthiest), the colorectal cancer rates were 1.5 percent in regular aspirin-taking group and 1.6% in the non-regular aspirin group. <a name="_Hlk173157308" id="_Hlk173157308"></a>This means that in the least healthy group, treating 78 patients with aspirin would prevent one case of colorectal cancer over a 10-year period, while it would take treating 909 patients to prevent one case for the healthiest group. Lifestyle scores were calculated based on body mass index, frequency of cigarette and alcohol use, physical activity, and adherence to a high-quality diet.</p> <p>“Our results show that aspirin can proportionally lower the markedly elevated risk in those with multiple risk factors for colorectal cancer,” said Daniel Sikavi, MD, lead author of the paper and a gastroenterologist at MGH. “In contrast, those with&nbsp;a&nbsp;healthier lifestyle have&nbsp;a&nbsp;lower baseline risk of colorectal cancer, and, therefore, their benefit from aspirin was still evident, albeit less pronounced.”</p> <p>One outcome of the study could be that “healthcare providers might more strongly consider recommending aspirin to patients who have less healthy lifestyles,” said co-senior author Long H. Nguyen, MD, MS, a&nbsp;physician investigator in the Clinical and Translational Epidemiology Unit and Division of Gastroenterology at MGH and a Chen Institute Department of Medicine Transformative Scholar at MGH.</p> <p>While the study included those who took regular standard-dose (325-mg) aspirin two times a week in the regular-aspirin using category, Sikavi noted that “based on prior studies, the best evidence supports daily low-dose&nbsp;(81-mg) aspirin&nbsp;for prevention.”</p> <p>Previous studies have found evidence to suggest aspirin can reduce the production of pro-inflammatory proteins, known as prostaglandins, that can promote the development of cancer. Aspirin may also block signaling pathways that cause cells to grow out of control, influence the immune response against cancer cells, and block the development of blood vessels that supply nutrients to cancer cells. “Aspirin likely prevents colorectal cancer through&nbsp;multiple mechanisms,” Chan said.</p> <p>The study did not assess potential side effects of daily aspirin use, such as bleeding. In addition, while the study tried to control for a wide range of risk factors for colorectal cancer, in comparing non-aspirin and aspirin-taking groups with the same level of risk factors, because this was an observational study, it is possible there may have been additional factors that influenced the findings.</p> <hr> <p><b>Authorship: </b>In addition to Sikavi, Chan, and Nguyen, Mass General Brigham authors include Wenjie Ma (MGH), David A. Drew (MGH), Shuji Ogino (BWH), Edward L. Giovannucci (BWH), and Mingyang Song (MGH). Additional authors include Kai Wang and Yin Cao.<b></b></p> <p><b>Disclosures: </b>Chan reported receiving personal fees from Boehringer Ingelheim, Pfizer Inc, and Freenome outside the submitted work.<b></b></p> <p><b>Funding: </b>The research was supported by grants for the Nurses' Health study and the Health Professionals Follow-Up Study from the National Cancer Institute and the American Cancer Society.<b></b></p> <p><b>Paper cited:</b> Sikavi, D <i>et al.</i> “Aspirin Use and Incidence of Colorectal Cancer According to Lifestyle Risk” <i>JAMA Oncology</i> DOI: 10.1001/jamaoncol.2024.2503</p> </div> </div> <div class="experiencefragment aem-GridColumn aem-GridColumn--default--12"> <div id="experiencefragment-6b190e82a8" class="cmp-experiencefragment cmp-experiencefragment--media-contact"> <div id="container-139ce91755" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="contact-block cmp-contact-block-contact cmp-contact-block-contact-standard aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-contact-block-contact-container"> <div class="cmp-contact-block-details-container"> <div class="cmp-contact-block-details"> <h2 class="cmp-contact-block-title">Media contact</h2> <div class="cmp-contact-block-title-divider"></div> <div class="cmp-contact-block-details-info-container no-image"> <div class="cmp-contact-block-name"> <span class="cmp-contact-block-name-field">Elizabeth Murphy</span> </div> <div class="cmp-contact-block-job-title">Program Director, External Communications</div> <div class="cmp-contact-block-email-phone"> <a class="cmp-contact-block-email-link" href="mailto: emurphy&#64;mgb.org">emurphy&#64;mgb.org</a> </div> </div> </div> <div class="cmp-contact-block-call-button"> <div class="global-button button cmp-injectedComponent"> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="experiencefragment aem-GridColumn aem-GridColumn--default--12"> <div id="experiencefragment-0f0a7b1b80" class="cmp-experiencefragment cmp-experiencefragment--about-mgb"> <div id="container-c164c41d13" class="cmp-container"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div data-cmp-data-layer="{&#34;text-4cf953dc2e&#34;:{&#34;@type&#34;:&#34;aem-mgb/components/text&#34;,&#34;repo:modifyDate&#34;:&#34;2024-01-11T23:56:50Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>About Mass General Brigham&lt;/h3>\r\n&lt;p>Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals. For more information, please visit &lt;a href=\&#34;https://www.massgeneralbrigham.org/en\&#34; target=\&#34;_self\&#34;>massgeneralbrigham.org&lt;/a>.&lt;/p>\r\n&#34;}}" id="text-4cf953dc2e" class="cmp-text"> <h3>About Mass General Brigham</h3> <p>Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals. 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