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Deadline 4 July 2025.</p> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item c-media c-media--stacked" data-fragment="27689802"> <div class="c-media__figure"> <div class="cms-item c-image-copyright" data-fragment="27508284"> <a href="https://www.biomedcentral.com/collections/AIAC" class="p-corner-crop"> <img src="//media.springernature.com/lw900/springer-cms/rest/v1/content/27508284/data/v3" alt="EAL small"/> </a> </div> </div> <div class="c-media__body"> <h2 class="c-media__title u-text-md"> <a href="https://www.biomedcentral.com/collections/AIAC">Call for papers - AI applications in cancer discovery and care</a> </h2> <p><em>Genome Medicine</em> is calling for submissions to a new Collection on how artificial intelligence in oncology has increased dramatically in recent years, evolving from basic algorithm development research toward incorporation into clinical application, guest edited by Dr Jakob Nikolas Kather from Dresden University of Technology and Dr Mihaela Aldea from Gustave Roussy. Deadline 10 June 2025.</p> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item c-media c-media--stacked" data-fragment="27689134"> <div class="c-media__figure"> <div class="cms-item c-image-copyright" data-fragment="27505334"> <a href="https://www.biomedcentral.com/collections/CTR" class="p-corner-crop"> <img src="//media.springernature.com/lw900/springer-cms/rest/v1/content/27505334/data/v3" alt="EAL small"/> </a> </div> </div> <div class="c-media__body"> <h2 class="c-media__title u-text-md"> <a href="https://www.biomedcentral.com/collections/CTR">Call for papers - Clinical trials resource</a> </h2> <p><em>Genome Medicine</em> is pleased to announce a call for papers for our Clinical Trials Resource, guest edited by Christophe Le Tourneau from the Institut Curie. We encourage work from academic-industry partnerships as well as collaboration among scientists from multi-disciplinary fields. Deadline 6 June 2025.</p> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item c-media c-media--stacked" data-fragment="27220722"> <div class="c-media__figure"> <div class="cms-item c-image-copyright" data-fragment="27392898"> <a href="https://www.biomedcentral.com/collections/GRRD" class="p-corner-crop"> <img src="//media.springernature.com/lw900/springer-cms/rest/v1/content/27392898/data/v1" alt="New Content Item"/> </a> </div> </div> <div class="c-media__body"> <h2 class="c-media__title u-text-md"> <a href="https://www.biomedcentral.com/collections/GRRD">Call for papers - Genomic research and clinical interventions for rare diseases</a> </h2> <p><em>Genome Medicine</em> is calling for submissions to a new Collection on genomic research and clinical advances in rare diseases, guest edited by Anna Lindstrand and Claudia Carvalho. Deadline 16 April 2025.</p> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item c-media c-media--stacked" data-fragment="26532928"> <div class="c-media__figure"> <div class="cms-item c-image-copyright" data-fragment="26502622"> <a href="https://www.biomedcentral.com/collections/AHAA" class="p-corner-crop"> <img src="//media.springernature.com/lw900/springer-cms/rest/v1/content/26502622/data/v5" alt="Collection image"/> </a> </div> </div> <div class="c-media__body"> <h2 class="c-media__title u-text-md"> <a href="https://www.biomedcentral.com/collections/AHAA">Call for papers - Advances in healthy aging and age-related diseases</a> </h2> <p><em>Genome Medicine</em> is calling for submissions to a new Collection on advances in healthy aging and<br />age-related diseases, guest edited by Joris Deelen and Henne Holstege. Deadline 1 April 2025.</p> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item c-media c-media--stacked" data-fragment="25958198"> <div class="c-media__figure"> <div class="cms-item c-image-copyright" data-fragment="27392888"> <a href="https://www.biomedcentral.com/collections/TICCPT" class="p-corner-crop"> <img src="//media.springernature.com/lw900/springer-cms/rest/v1/content/27392888/data/v1" alt="New Content Item"/> </a> </div> </div> <div class="c-media__body"> <h2 class="c-media__title u-text-md"> <a href="https://www.biomedcentral.com/collections/TICCPT">Call for papers - Tumor immune contexture in cancer progression and treatment</a> </h2> <p><em>Genome Medicine</em> is calling for submissions to a new Collection on Tumor immune contexture in cancer progression and treatment guest edited by Noel De Miranda.<strong> </strong>Deadline 31 December 2024.</p> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item c-media c-media--stacked" data-fragment="27220724"> <div class="c-media__figure"> <div class="cms-item c-image-copyright" data-fragment="27392896"> <a href="https://www.biomedcentral.com/collections/tmhd" class="p-corner-crop"> <img src="//media.springernature.com/lw900/springer-cms/rest/v1/content/27392896/data/v1" alt="New Content Item"/> </a> </div> </div> <div class="c-media__body"> <h2 class="c-media__title u-text-md"> <a href="https://www.biomedcentral.com/collections/tmhd">Call for papers - Translating the microbiome in health and disease</a> </h2> <p><em>Genome Medicine</em> is calling for submission to a new Collection on translating the microbiome in health and disease guest edited by Peggy Lai. Deadline 1 December 2024.</p> </div> </div> </div> </div> </div> </div> <div class="cms-item cms-collection cms-collection--split cms-collection--untitled" data-fragment="729672"> <div class="cms-collection__row"> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item cms-collection" data-fragment="729668"> <div id="reviews%2C+research+highlights+and+commentaries" class="cms-item cms-article" data-fragment="15903664"> <h2>Reviews, Research Highlights and Commentaries</h2> <div class="cms-article__body"> <p>Read authoritative Reviews, Opinions and other content commissioned by the <em>Genome Medicine</em> Editors from leading researchers:</p><p><a href="https://www.biomedcentral.com/collections/reviewsfromgenomemedicine" target="_blank" class="is-external">Reviews</a></p><p><a href="https://www.biomedcentral.com/collections/researchhighlightsfromgenomemedicine" target="_blank" class="is-external">Research Highlights</a></p><p><a href="https://www.biomedcentral.com/collections/commentariesfromgenomemedicine" target="_blank" class="is-external">Commentaries</a> (including Editorials, Comments, Opinions, Q&As and Meeting reports)</p> </div> </div> <div class="cms-item cms-collection" data-tabs="tabs" data-fragment="727166"> <h2 class="cms-collection__title">Articles</h2> <ul class="c-nav c-nav--tabs c-nav--fill u-mb-16" role="tablist"> <li role="presentation" class="c-nav__item"> <a class="c-nav__link is-active" href="#tab-1" aria-controls="tab-1" role="tab" data-toggle="tab" data-track="click" data-track-category="Recent" data-track-action="Clicked tab" >Recent</a> </li> <li role="presentation" class="c-nav__item"> <a class="c-nav__link" href="#tab-2" aria-controls="tab-2" role="tab" data-toggle="tab" data-track="click" data-track-category="Most accessed" data-track-action="Clicked tab" >Most accessed</a> </li> </ul> <div role="tabpanel" class="c-tab-content is-active" id="tab-1"> <div data-test="recent-articles"> <div data-track-component="Recent"> <div data-total="1866" data-test="search-content"> <ol class="c-listing"> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-024-01414-4" data-track="click||select_recent_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 0">Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Simon Lam, John C. Thomas and Stephen P. Jackson</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Software</span> <span itemprop="datePublished" data-test="published-on">26 November 2024</span> </div> </article> </li> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-024-01410-8" data-track="click||select_recent_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 1">Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Hao Duan, Jianlan Ren, Shiyou Wei, Zhenyu Yang, Chuan Li, Zhenning Wang, Meichen Li, Zhi Wei, Yu Liu, Xiuqi Wang, Hongbin Lan, Zhen Zeng, Maodi Xie, Yuan Xie, Suwen Wu, Wanming Hu…</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Research</span> <span itemprop="datePublished" data-test="published-on">26 November 2024</span> </div> </article> </li> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-024-01412-6" data-track="click||select_recent_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 2">Genomic surveillance of multidrug-resistant organisms based on long-read sequencing</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Fabian Landman, Casper Jamin, Angela de Haan, Sandra Witteveen, Jeroen Bos, Han G. J. van der Heide, Leo M. Schouls and Antoni P. A. Hendrickx</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Research</span> <span itemprop="datePublished" data-test="published-on">25 November 2024</span> </div> </article> </li> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-024-01401-9" data-track="click||select_recent_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 3">Mapping in silico genetic networks of the <em>KMT2D</em> tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf…</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Research</span> <span itemprop="datePublished" data-test="published-on">22 November 2024</span> </div> </article> </li> <li class="u-position-relative"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-024-01408-2" data-track="click||select_recent_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 4">Epigenetic age and long-term cancer risk following a stroke</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Antoni Su谩rez-P茅rez, Adri脿 Macias-G贸mez, Isabel Fern谩ndez-P茅rez, Marta Vallverd煤-Prats, Elisa Cuadrado-Godia, Eva Giralt-Steinhauer, Maia Campanale, Daniel Guisado-Alonso, Ana Rodr铆guez-Campello, Joan Jim茅nez-Balado, Jordi Jim茅nez-Conde and Angel Ois</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Research</span> <span itemprop="datePublished" data-test="published-on">22 November 2024</span> </div> </article> </li> </ol> </div> </div> <div class="u-display-flex u-justify-content-space-between u-align-items-baseline u-flex-wrap"> <p class="u-text-sm u-mr-16 u-mb-8"> <a href="/articles/most-recent/rss.xml" class="u-display-flex u-align-items-center" target="_blank" rel="noopener" data-test="recent-articles-feed"> Most recent articles RSS <svg class="u-icon u-flex-static u-ml-8" width="11" height="11" aria-hidden="true" focusable="false"> <use xlink:href="#icon-rss"></use> </svg> </a> </p> <p> <a href="/articles" class="u-button" data-track="click_all_articles" data-track-context="recent articles list section on bmc journal homepages" data-track-category="Recent" data-track-action="Clicked view all articles link"> <span class="u-display-flex u-align-items-center"> View all articles <svg class="u-flex-static u-ml-8" width="12" height="12" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> </span> </a> </p> </div> </div> </div> <div role="tabpanel" class="c-tab-content " id="tab-2"> <div data-test="most-accessed-articles"> <div data-track-component="Most accessed"> <div data-total="5" data-test="search-content"> <ol class="c-listing"> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-017-0467-4" data-track="click||select_most_accessed_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 0">A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Ashraful Haque, Jessica Engel, Sarah A. Teichmann and Tapio L枚nnberg</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Review</span> <span itemprop="datePublished" data-test="published-on">18 August 2017</span> </div> </article> </li> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-020-00791-w" data-track="click||select_most_accessed_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 1">Best practices for variant calling in clinical sequencing</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Daniel C. Koboldt</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Review</span> <span itemprop="datePublished" data-test="published-on">26 October 2020</span> </div> </article> </li> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/gm483" data-track="click||select_most_accessed_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 2">The Human Genome Project: big science transforms biology and medicine</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Leroy Hood and Lee Rowen</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Opinion</span> <span itemprop="datePublished" data-test="published-on">13 September 2013</span> </div> </article> </li> <li class="u-position-relative u-keyline"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-022-01075-1" data-track="click||select_most_accessed_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 3">An introduction to spatial transcriptomics for biomedical research</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Cameron G. Williams, Hyun Jae Lee, Takahiro Asatsuma, Roser Vento-Tormo and Ashraful Haque</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Review</span> <span itemprop="datePublished" data-test="published-on">27 June 2022</span> </div> </article> </li> <li class="u-position-relative"> <article class="c-listing__content" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="c-listing__title u-text-md u-text-normal" itemprop="name"> <a itemprop="url" href="/articles/10.1186/s13073-017-0424-2" data-track="click||select_most_accessed_article" data-track-context="journal homepage recent articles and most accessed articles tabbed article list section" data-track-action="Clicked article link" data-track-label="article 4">Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden</a> </h3> <p class="c-listing__authors u-mb-0" data-test="authors"><span class="u-visually-hidden">Authors: </span>Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber…</p> <div class="c-listing__metadata u-text-sm"> <span><span class="u-visually-hidden">Content type: </span>Research</span> <span itemprop="datePublished" data-test="published-on">19 April 2017</span> </div> </article> </li> </ol> </div> </div> <div class="u-display-flex u-justify-content-space-between u-align-items-baseline u-flex-wrap"> <p class="u-text-sm u-mr-16 u-mb-8"> <a href="/articles/most-accessed/rss.xml" class="u-display-flex u-align-items-center" target="_blank" rel="noopener" data-test="most-accessed-feed"> <span>Most accessed articles RSS</span> <svg class="u-icon u-flex-static u-ml-8" width="11" height="11" aria-hidden="true" focusable="false"> <use xlink:href="#icon-rss"></use> </svg> </a> </p> <p class="u-text-right"> <a href="/articles" class="u-button" data-track="click_all_articles" data-track-context="most accessed article list section on bmc journal homepages" data-track-category="Most accessed" data-track-action="Clicked view all articles link"> <span class="u-display-flex u-align-items-center"> View all articles <svg class="u-flex-static u-ml-8" width="16" height="16" aria-hidden="true" focusable="false"> <use xlink:href="#icon-chevron-right"></use> </svg> </span> </a> </p> </div> </div> </div> </div> <div id="focus%3A+the+human+microbiome+in+health+and+disease" class="cms-item cms-article" data-fragment="16121602"> <h2>Focus: The human microbiome in health and disease</h2> <div class="cms-article__body"> <p>Read the latest Research and and Reviews on the human microbiome in health and disease:</p><p><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00843-9" target="_blank" class="is-external">Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides </a><br><strong>Langdon, A., Schwartz, D.J., Bulow, C. et al. </strong>Genome Med 13, 28 (2021)</p><p><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00923-w" target="_blank" class="is-external">Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer</a><br><strong>Hayase, E., Jenq, R.R. </strong>Genome Med 13, 107 (2021)</p><p><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00765-y" target="_blank" class="is-external">Strain-level epidemiology of microbial communities and the human microbiome</a><br><strong>Yan, Y., Nguyen, L.H., Franzosa, E.A. et al. </strong>Genome Med 12, 71 (2020).<br><br><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00974-z" target="_blank" class="is-external">Bacteroides vulgatus and Bacteroides dorei predict immune-related adverse events in immune checkpoint blockade treatment of metastatic melanoma</a><br><strong>Usyk, M., Pandey, A., Hayes, R.B. et al. </strong>Genome Med 13, 160 (2021).</p> </div> </div> </div> </div> </div> <div class="cms-collection__column"> <div class="cms-collection__column-inner"> <div class="cms-item cms-collection" data-fragment="729670"> <div id="aims+and+scope" class="cms-item cms-article" data-fragment="6487454"> <h2>Aims and scope</h2> <div class="cms-article__body"> <p><em>Genome Medicine</em> publishes important advances of broad interest in the application of genetics, genomics and multi-omics to understand, diagnose and treat disease. The Journal aims to bridge the basic science and clinical research communities in areas that include, but are not limited to: cancer genomics, immuno-oncology, immunogenomics, infectious disease, microbiome, cardiology, neurogenomics, systems medicine, clinical genomics, gene therapies, precision medicine, and clinical trials. 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