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false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":50265473,"created_at":"2021-07-26T05:17:10.972-07:00","from_world_paper_id":171162419,"updated_at":"2024-11-24T07:13:38.478-08:00","_data":{"publisher":"Excellent Publishers","grobid_abstract":"Neonatal sepsis is one of the major causes of morbidity and mortality in the newborn. The most common isolates in the early onset septicemia are Klebsiella Spp. Bacterial isolates and their antibiotic susceptibility has been constantly changing. Thus the aim of the study was to isolate the aerobic bacteria responsible for early onset neonatal septicemia and determination of their antibiotic sensitivity pattern. The present study was conducted in department of microbiology of a tertiary care hospital. Blood sample were collected from 268 clinically suspected cases of neonatal septicemia admitted in the neonatal intensive care unit. About 1ml of blood was inoculated into 10ml of brain heart infusion (BHI) broth and incubates for 7 days. Repeated sub-culturing was done as per standard procedures. Any growth was subjected for identification by appropriate biochemical tests. Antibiotic susceptibility testing was done. Out of 83 culture positive cases, early onset septicemia was seen in 75(90.4%) cases. Gram negative organisms (63%) were predominant than Gram positive organisms (36%). Klebsiella pneumoniae (43%) and Coagulase Negative Staphylococcus (36%) were the common organisms isolated. Gram negative bacteria were resistant to routinely used antibiotics and were highly sensitive to Imipenem (100%). The Gram positive bacteria showed high resistance to Ampicilin (90%). Gram negative organisms mainly Klebsiella pneumoniae were most common agents causing early onset neonatal sepsis, their resistance pattern should be considered essential for deciding the empirical treatment.","publication_name":"International Journal of Current Microbiology and Applied Sciences","grobid_abstract_attachment_id":"68316438"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"A Study of Bacteriological Profile and Antibiogram of Early Onset Sepsis in a Tertiary Care Hospital","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [163571913]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":68316438,"attachmentType":"pdf"}"><img alt="First page of “A Study of Bacteriological Profile and Antibiogram of Early Onset Sepsis in a Tertiary Care Hospital”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/68316438/mini_magick20210726-31234-ghnzn1.png?1627301925" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">A Study of Bacteriological Profile and Antibiogram of Early Onset Sepsis in a Tertiary Care Hospital</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="163571913" href="https://independent.academia.edu/AnushkaDevnikar"><img alt="Profile image of Anushka Devnikar" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Anushka Devnikar</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">International Journal of Current Microbiology and Applied Sciences</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">7 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 50265473; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=50265473"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Neonatal sepsis is one of the major causes of morbidity and mortality in the newborn. The most common isolates in the early onset septicemia are Klebsiella Spp. Bacterial isolates and their antibiotic susceptibility has been constantly changing. Thus the aim of the study was to isolate the aerobic bacteria responsible for early onset neonatal septicemia and determination of their antibiotic sensitivity pattern. The present study was conducted in department of microbiology of a tertiary care hospital. Blood sample were collected from 268 clinically suspected cases of neonatal septicemia admitted in the neonatal intensive care unit. About 1ml of blood was inoculated into 10ml of brain heart infusion (BHI) broth and incubates for 7 days. Repeated sub-culturing was done as per standard procedures. Any growth was subjected for identification by appropriate biochemical tests. Antibiotic susceptibility testing was done. Out of 83 culture positive cases, early onset septicemia was seen in 75(90.4%) cases. Gram negative organisms (63%) were predominant than Gram positive organisms (36%). Klebsiella pneumoniae (43%) and Coagulase Negative Staphylococcus (36%) were the common organisms isolated. Gram negative bacteria were resistant to routinely used antibiotics and were highly sensitive to Imipenem (100%). The Gram positive bacteria showed high resistance to Ampicilin (90%). Gram negative organisms mainly Klebsiella pneumoniae were most common agents causing early onset neonatal sepsis, their resistance pattern should be considered essential for deciding the empirical treatment.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":68316438,"attachmentType":"pdf","workUrl":"https://www.academia.edu/50265473/A_Study_of_Bacteriological_Profile_and_Antibiogram_of_Early_Onset_Sepsis_in_a_Tertiary_Care_Hospital"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":68316438,"attachmentType":"pdf","workUrl":"https://www.academia.edu/50265473/A_Study_of_Bacteriological_Profile_and_Antibiogram_of_Early_Onset_Sepsis_in_a_Tertiary_Care_Hospital"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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The most common pathogens of bacterial sepsis and antibiotic sensitivity patterns vary in different parts of the world. The aim of this study was to determine the most common pathogens and outcome of neonatal sepsis and also antibiotic sensitivity patterns of Klebsiella species. A retrospective descriptive study was carried out. The study was performed at a neonatal care unit in Kashan between October 2000 to October 2003.Only those neonates with positive blood culture were included. Patients with Klebsiella septicemia were categorized into two groups of early and late-onset sepsis. Patterns of the antibiotic resistance of the bacterial isolates were studied by disc diffusion technique. Frequencies and Fisher's Exact test was used to compare the early-onset outcome versus late-onset outcome. One hundred and thirty-six neonates had positive blood cultures out of 453 cases. The most common pathogens were Pseudomonas, Klebsiella and coagulase negative Staphylococci respectively. Overall crude mortality rate was 39% (Pseudomonas was the predominant cause). All Klebsiella species were resistant to ampicillin. Twenty-three percent of Klebsiella species were multiresistant considering our most common etiologic pathogens of bacterial sepsis and the significant number of resistant bacteria to ampicillin and gentamicin; it seems prudent to consider revising the present choice of empirical antibiotic treatment.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Sepsis due to Klebsiella: Frequency, Outcome and Antibiotic Sensitivity","attachmentId":70245082,"attachmentType":"pdf","work_url":"https://www.academia.edu/53366579/Neonatal_Sepsis_due_to_Klebsiella_Frequency_Outcome_and_Antibiotic_Sensitivity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53366579/Neonatal_Sepsis_due_to_Klebsiella_Frequency_Outcome_and_Antibiotic_Sensitivity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="26699231" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26699231/Identification_of_bacterial_agents_and_antimicrobial_susceptibility_of_neonatal_sepsis_A_54_month_study_in_a_tertiary_hospital">Identification of bacterial agents and antimicrobial susceptibility of neonatal sepsis: A 54-month study in a tertiary hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50693053" href="https://independent.academia.edu/MohammadAletayeb">Mohammad Aletayeb</a></div><p class="ds-related-work--metadata ds2-5-body-xs">African journal of microbiology research</p><p class="ds-related-work--abstract ds2-5-body-sm">The spectrum of bacteria which cause neonatal sepsis varies in different parts of the world. Antibiotic resistance is an increasing problem of these bacteria. The aim of this study was to detect the most common bacterial causes of neonatal sepsis and determination of their sensitivity to antibiotics. In a descriptive cross-sectional study, records of the neonates suspicious to neonatal sepsis who were admitted to Neonatal Intensive Care Unit (NICU) were assessed. Neonates with positive blood culture along with clinical signs of sepsis were entered in the study. Evaluated data included: age, sex, birth weight, type of infection, type of isolated pathogen, antibiotic sensitivity and disease outcome. Of 3700 screened blood cultures, 153 (4.1%) reported as positive, 76.5% of the evaluated neonates were preterm, 142 (92.8%) had gram negative sepsis and 11 (7.2%) had gram positive sepsis. The most common isolated gram negative bacteria were Klebsiella pneumoniae (46.4%), enterobacter spp. (17.6%) and Escherishia coli (14.4%). Coagulase negative staphylococci (CONS) were the most prevalent gram positive bacteria (5.9%) in this study. All of the klebsiella and enterobacter strains were resistant to ampicillin and gentamicin. The sensitivity of K. pneumoniae and enterobacter to imipenem was: 90 and 92.5%, respectively. Prevalence of early and late-onset sepsis was 64.7 and 35.3% respectively. Mortality rate of sepsis in this study was reported as 53.5%. In conclusion, the most common cause of bacterial sepsis in this study was K. pneumoniae which was completely resistant to ampicillin and gentamicin. So empirical treatment of sepsis with ampicillin and gentamicin in Imam Khomeini NICU must be reconsidered.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Identification of bacterial agents and antimicrobial susceptibility of neonatal sepsis: A 54-month study in a tertiary hospital","attachmentId":46981166,"attachmentType":"pdf","work_url":"https://www.academia.edu/26699231/Identification_of_bacterial_agents_and_antimicrobial_susceptibility_of_neonatal_sepsis_A_54_month_study_in_a_tertiary_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26699231/Identification_of_bacterial_agents_and_antimicrobial_susceptibility_of_neonatal_sepsis_A_54_month_study_in_a_tertiary_hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="92834457" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92834457/Neonatal_Sepsis_The_impact_of_Hypervirulent_Klebsiella_pneumonia_in_a_Tertiary_Care_Hospital">Neonatal Sepsis: The impact of Hypervirulent Klebsiella pneumonia in a Tertiary Care Hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55758140" href="https://independent.academia.edu/danisvijay">danis vijay</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Pure and Applied Microbiology</p><p class="ds-related-work--abstract ds2-5-body-sm">Neonatal sepsis is a blood-stream infection that affects newborns under the age of 28 days. Sepsis is common in NICUs and has a high prevalence of Klebsiella species. As a result, the study aims to find the antibiotic resistance profile, virulence factors, and the prognosis of K. pneumoniae-infected neonates. A prospective study was conducted which included 140 neonates with clinical sepsis. Characterization of Klebsiella pneumonia isolates was done by conventional methods. Drug resistance and virulence factors were detected by phenotypic methods. Genotypic methods included 16s rRNA amplification and sequencing. Detection of multidrug-resistant genes by PCR was performed. K. pneumoniae (26.9%) was the most common pathogen isolated. A high prevalence of ESBL was detected (58.8%). The prevalence of CRKP and MβL was about 29.4%, and 23.5% respectively. Two strains were Strong biofilm producers and nine isolates showed Beta hemolysis.7 strains were positive for the string test. Four str...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Sepsis: The impact of Hypervirulent Klebsiella pneumonia in a Tertiary Care Hospital","attachmentId":95738504,"attachmentType":"pdf","work_url":"https://www.academia.edu/92834457/Neonatal_Sepsis_The_impact_of_Hypervirulent_Klebsiella_pneumonia_in_a_Tertiary_Care_Hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92834457/Neonatal_Sepsis_The_impact_of_Hypervirulent_Klebsiella_pneumonia_in_a_Tertiary_Care_Hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="26998950" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26998950/Bacteriological_profile_and_antibiogram_of_neonatal_septicemia_in_a_tertiary_care_hospital">Bacteriological profile and antibiogram of neonatal septicemia in a tertiary care hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Innovative publication, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Neonatal sepsis is a clinical syndrome which is characterised by signs and symptoms of infection which may or may not be accompanied by bacteraemia within the first month of life. The bacteriological profile of neonatal sepsis is under constant change with the advances in the diagnosis and treatment. Blood culture is still the mainstay of investigation of potential sepsis in spite of the recent advances in molecular diagnosis of fungal and bacterial sepsis. Most common bacterial organisms responsible for neonatal septicaemia in developing countries like Bangladesh, India, Nigeria, Pakistan, are Klebsiella, Escherichia coli, Enterobacter etc. The present study was undertaken to describe the spectrum of the isolates in cases of neonatal septicaemia, and their antimicrobial susceptibility pattern. The study was carried out over a one year period. Method: A total of 357 suspected patients of neonatal septicaemia were included in the study. Blood samples were collected with aseptic precautions preferably prior to the initiation of empiric antibiotic therapy. The bottles were incubated aerobically at 37 0 C for 7 days and subcultured on blood agar and Mac Conkey agar. If growth appeared the isolates were processed as per standard microbiological techniques and the isolates were identified. Antibiotic sensitivity testing was performed on Mueller‑Hinton agar plates by modified Kirby‑Bauer disk diffusion method as per Clinical Laboratory Standard Institute guidelines. Results: Of the 357 samples studied, growth was observed in 154 samples. Gram positive organisms constituted 37.66% and gram negative bacilli constituted 62.34% of the isolates. The predominant pathogens isolated were Klebsiella species, Coagulase Negative Staphylococci, Staphylococcus aureus followed by Non fermenting gram negative bacilli. 71.43% of the Staphylococcus aureus isolates were found to be methicillin resistant.96.05% of the Enterobacteriaceae were found to be Extended Spectrum Beta Lactamase (ESBL) producers. 33.33% of the Pseudomonas isolates were found to be metallo-beta-lactamase (MBL) producers. Conclusion: This study shows that Klebsiella species, Coagulase Negative Staphylococci, Staphylococcus aureus and Non-fermenting gram negative bacilli were the commonest organisms associated with Neonatal sepsis. An alarmingly high rate of MRSA and ESBL producers was observed. This study stresses that antimicrobial resistance is a universal problem and it stresses the need for surveillance.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriological profile and antibiogram of neonatal septicemia in a tertiary care hospital","attachmentId":47259736,"attachmentType":"pdf","work_url":"https://www.academia.edu/26998950/Bacteriological_profile_and_antibiogram_of_neonatal_septicemia_in_a_tertiary_care_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26998950/Bacteriological_profile_and_antibiogram_of_neonatal_septicemia_in_a_tertiary_care_hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="121940430" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/121940430/Bacterial_Isolates_and_its_Antibiotic_Susceptibility_Pattern_in_NICU">Bacterial Isolates and its Antibiotic Susceptibility Pattern in NICU</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="268799373" href="https://independent.academia.edu/shovashrestha28">shova shrestha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Kathmandu University Medical Journal, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Background Neonatal sepsis is one of the major causes of morbidity and mortality among the newborns in the developing world. Objectives To determine the common bacterial isolates causing sepsis in neonatal intensive care unit and its antibiotic susceptibility pattern. Methods A one year discriptive prospective study was conducted in neonatal intensive care unit to analyse the results of blood culture and to look into the sensitivity of the commonly used antibiotics. Results The blood culture yield by conventional method was 44.13% with nosocomial sepsis accounting for 10.79%. 84.08% were culture proven early onset sepsis and 15.95% were late onset sepsis. Klebsiella infection was the commonest organism isolated in early, late and nosocomial sepsis but statistically not significant. Gram positive organisms were 39.36% in which Staphylococcus aureus was the leading microorganism followed by coagulase negative staphylococcus areus. Gram negative organisms were 60.64% amongst them Klebs...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacterial Isolates and its Antibiotic Susceptibility Pattern in NICU","attachmentId":116705052,"attachmentType":"pdf","work_url":"https://www.academia.edu/121940430/Bacterial_Isolates_and_its_Antibiotic_Susceptibility_Pattern_in_NICU","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/121940430/Bacterial_Isolates_and_its_Antibiotic_Susceptibility_Pattern_in_NICU"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="33088148" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33088148/Klebsiella_pneumoniae_in_neonatal_sepsis_a_3_year_study_in_the_pediatric_hospital_of_Tabriz_Iran">Klebsiella pneumoniae in neonatal sepsis: a 3-year-study in the pediatric hospital of Tabriz, Iran</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="64392487" href="https://independent.academia.edu/RezaGhotaslou">Prof. Reza Ghotaslou</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Japanese journal of infectious diseases, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Neonatal sepsis is a life-threatening emergency, and any delay in treatment may cause death. Because of the importance of the problem in Iran, the aim of this retrospective study was to determine the etiological agents of neonatal septicemia, and the prevalence and epidemiology of Klebsiella bacteremia in the neonatal wards. Two hundred and ten cases of neonatal sepsis occurred during the study period. The most common organism was coagulase-negative staphylococci. Gram-negative organisms were isolated in 66 cases (31.43%), and the most common Gram-negative organism causing neonatal sepsis was Klebsiella pneumoniae. The mortality rate due to Gram-negative bacteria including K. pneumoniae was higher than that due to other bacteria. The distribution of the main pathogens is different in the Azerbaijan state, northwest of Iran, and K. pneumoniae is predominant, but Streptococcus agalactiae plays a relatively minor role in the etiology of sepsis during the first month of life.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Klebsiella pneumoniae in neonatal sepsis: a 3-year-study in the pediatric hospital of Tabriz, Iran","attachmentId":53187991,"attachmentType":"pdf","work_url":"https://www.academia.edu/33088148/Klebsiella_pneumoniae_in_neonatal_sepsis_a_3_year_study_in_the_pediatric_hospital_of_Tabriz_Iran","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33088148/Klebsiella_pneumoniae_in_neonatal_sepsis_a_3_year_study_in_the_pediatric_hospital_of_Tabriz_Iran"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="41322041" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/41322041/Bacteriological_Profile_of_Neonatal_Septicemia_and_Antibiogram_of_Isolates">Bacteriological Profile of Neonatal Septicemia and Antibiogram of Isolates</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2594470" href="https://independent.academia.edu/iosrjournals">IOSR Journals</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IOSR Journals , 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in first four weeks of life. It is the leading cause of neonatal mortality and morbidity in India. Aim: To isolate and identify the bacteriologic etiologic agents responsible for neonatal sepsis and to determine the susceptibility pattern of isolates at Kurnool Medical College and Govt General Hospital, Kurnool. Materials and Methods: Two hundred and fifty two samples were collected from neonates for a period of ten months and processed in accordance with standard protocols. Antibiotic susceptibility of the isolates was done by Kirby-Bauer disc diffusion method as recommended in the National Committee for Clinical Laboratory Standards (NCCLS) guidelines. Results: Blood culture reports were positive in 54.7% cases. Among the culture positive cases, Gram positive isolates were 12.6% and Gram negative isolates were 42.1%. Staphylococcus aureus was the predominant Gram positive organism isolated and Klebsiella spp. was the predominant Gram negative organism isolated. Best overall sensitivity among Gram-negative isolates was to Imipenem (95.2%) followed by Tigecycline (92.8%).Gram positive isolates had sensitivity of 96.4% to Linezolid, 82% sensitivity to Vancomycin. Conclusion: Gram negative organisms are the leading cause of neonatal sepsis in this study and most of them are multi drug resistant. Therefore this study highlights the emergence of multi drug resistant strains at tertiary care centre.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriological Profile of Neonatal Septicemia and Antibiogram of Isolates","attachmentId":61527657,"attachmentType":"pdf","work_url":"https://www.academia.edu/41322041/Bacteriological_Profile_of_Neonatal_Septicemia_and_Antibiogram_of_Isolates","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/41322041/Bacteriological_Profile_of_Neonatal_Septicemia_and_Antibiogram_of_Isolates"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="106328797" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/106328797/Neonatal_Sepsis_Antibiotic_Sensitivity_and_Resistance_Pattern_of_Most_Common_Isolated_Pathogens_in_a_Neonatal_Intensive_Care_Unit_of_a_Tertiary_Care_Hospital">Neonatal Sepsis: Antibiotic Sensitivity and Resistance Pattern of Most Common Isolated Pathogens in a Neonatal Intensive Care Unit of a Tertiary Care Hospital</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="252644365" href="https://independent.academia.edu/PrakashWaghmare19">Prakash Waghmare</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Current Microbiology and Applied Sciences, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal Sepsis: Antibiotic Sensitivity and Resistance Pattern of Most Common Isolated Pathogens in a Neonatal Intensive Care Unit of a Tertiary Care Hospital","attachmentId":105556173,"attachmentType":"pdf","work_url":"https://www.academia.edu/106328797/Neonatal_Sepsis_Antibiotic_Sensitivity_and_Resistance_Pattern_of_Most_Common_Isolated_Pathogens_in_a_Neonatal_Intensive_Care_Unit_of_a_Tertiary_Care_Hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/106328797/Neonatal_Sepsis_Antibiotic_Sensitivity_and_Resistance_Pattern_of_Most_Common_Isolated_Pathogens_in_a_Neonatal_Intensive_Care_Unit_of_a_Tertiary_Care_Hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="105845538" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105845538/Antimicrobial_Resistance_by_Bacteria_That_Colonize_Neonates_With_Suspected_Sepsis">Antimicrobial Resistance by Bacteria That Colonize Neonates With Suspected Sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32827398" href="https://independent.academia.edu/SelmaPasi%C4%87">Selma Pasić</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Central European Journal of Paediatrics, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective â€“ The aim of this study was to determine the antibiotic resistance in bacteria that colonized neonates with suspected sepsis, born in the Department of Gynecology and Obstetrics, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina from December 1, 2008 to December 31, 2009.Â Methods â€“ The study included neonates who were discharged from the Maternity ward, who developed clinical signs of suspected sepsis after forty eight hours of life, and were therefore rehospitalized at the Department of Pediatrics in Tuzla.Â Results â€“ The study showed that 55 of 4299 newborns were diagnosed with suspected sepsis. The cumulative incidence of suspected sepsis was 1.3% The bacteria that most often colonized neonates was Klebsiella pneumoniae, that was isolated in 42 (76.4%) newborns. In 14 cases (33.3%) Klebsiella was ESBLâ€“producing. Moreover we found Escherichia coli in 5 neonates (9%), Enterococcus faecalis in 5 neonates (9%) and Enterobacter Cloacae in 3 neonates ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antimicrobial Resistance by Bacteria That Colonize Neonates With Suspected Sepsis","attachmentId":105201544,"attachmentType":"pdf","work_url":"https://www.academia.edu/105845538/Antimicrobial_Resistance_by_Bacteria_That_Colonize_Neonates_With_Suspected_Sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/105845538/Antimicrobial_Resistance_by_Bacteria_That_Colonize_Neonates_With_Suspected_Sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="91832724" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91832724/Study_of_the_bacteriological_profile_of_neonatal_septicemia_and_associated_risk_factors">Study of the bacteriological profile of neonatal septicemia and associated risk factors</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="129543229" href="https://independent.academia.edu/amruthakumari2">amrutha kumari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP International Journal of Medical Microbiology and Tropical Diseases, 2020</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Neonatal sepsis is one of the major causes of morbidity and mortality among the newborns in the developing countries. For the effective management of neonatal sepsis, knowledge about causative agent and antibiotic sensitivity pattern play a vital role. Present study was undertaken to analyze the various risk factors of bacterial sepsis, to isolate aerobic bacteria causing neonatal septicemia and to study the antibiogram of bacterial isolates. Material and Methods: Study was done over a period of one year. 198 clinically suspected cases of neonatal septicemia were included in the study. Detailed record of various predisposing neonatal factors were noted in a pro-forma. Blood samples from the neonates were subjected to aerobic blood cultures. The identification of the causative organism was carried out by standard identification tests and antibiotic sensitivity testing was done as per Clinical and Laboratory Standards Institute guidelines. Results: Of 198 neonates studied, predisposing factors for neonatal sepsis were mainly low birth-weight and preterm. Blood cultures were positive in 128(64.64%) cases. Predominant organisms isolated were Staphylococcus aureus (54.7%) and Klebsiella spp. (14.1%). Among Staphylococcus aureus, 43(61.42%) isolates were MRSA and most of them were sensitive only to vancomycin and linezolid. Most of the MSSA were sensitive to cotrimoxazole, clindamycin, ciprofloxacin, vancomycin, linezolid. Most of the Gram negative bacilli were sensitive to imipenem, piperacillin-tazobactam and amikacin. Conclusion: For the effective management of neonatal sepsis continued surveillance is mandatory for each center due to temporal changes in the causative organisms and their antibiotic susceptibility.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study of the bacteriological profile of neonatal septicemia and associated risk factors","attachmentId":95007361,"attachmentType":"pdf","work_url":"https://www.academia.edu/91832724/Study_of_the_bacteriological_profile_of_neonatal_septicemia_and_associated_risk_factors","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/91832724/Study_of_the_bacteriological_profile_of_neonatal_septicemia_and_associated_risk_factors"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":68316438,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":68316438,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_68316438" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="114605006" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/114605006/Neonatal_sepsis_high_antibiotic_resistance_of_the_bacterial_pathogens_in_a_neonatal_intensive_care_unit_of_a_tertiary_care_hospital">Neonatal sepsis: high antibiotic resistance of the bacterial pathogens in a neonatal intensive care unit of a tertiary care hospital</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7844421" href="https://independent.academia.edu/AbidMahmood2">Abid Mahmood</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of clinical neonatology, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neonatal sepsis: high antibiotic resistance of the bacterial pathogens in a neonatal intensive care unit of a tertiary care hospital","attachmentId":111259631,"attachmentType":"pdf","work_url":"https://www.academia.edu/114605006/Neonatal_sepsis_high_antibiotic_resistance_of_the_bacterial_pathogens_in_a_neonatal_intensive_care_unit_of_a_tertiary_care_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/114605006/Neonatal_sepsis_high_antibiotic_resistance_of_the_bacterial_pathogens_in_a_neonatal_intensive_care_unit_of_a_tertiary_care_hospital"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="38700404" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38700404/Multidrug_resistance_pattern_in_bacteriological_isolates_of_neonatal_septicemia_in_NICU_of_a_tertiary_care_center">Multidrug resistance pattern in bacteriological isolates of neonatal septicemia in NICU of a tertiary care center</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="238719092" href="https://independent.academia.edu/FareyaHaider">Fareya Haider</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP Innovative Publication Pvt. Ltd., 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Multidrug resistance pattern in bacteriological isolates of neonatal septicemia in NICU of a tertiary care center","attachmentId":58783466,"attachmentType":"pdf","work_url":"https://www.academia.edu/38700404/Multidrug_resistance_pattern_in_bacteriological_isolates_of_neonatal_septicemia_in_NICU_of_a_tertiary_care_center","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/38700404/Multidrug_resistance_pattern_in_bacteriological_isolates_of_neonatal_septicemia_in_NICU_of_a_tertiary_care_center"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="43032656" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43032656/Bacteriology_of_neonatal_septicemias_in_a_tertiary_care_hospital">Bacteriology of neonatal septicemias in a tertiary care hospital</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27377481" href="https://innovativepublication.academia.edu/IP">IP Innovative Publication Pvt. Ltd.</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="158794764" href="https://independent.academia.edu/YRRReddy">Y. R. R. Reddy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">IP innovative publication pvt ltd, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Bacteriology of neonatal septicemias in a tertiary care hospital","attachmentId":63294192,"attachmentType":"pdf","work_url":"https://www.academia.edu/43032656/Bacteriology_of_neonatal_septicemias_in_a_tertiary_care_hospital","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/43032656/Bacteriology_of_neonatal_septicemias_in_a_tertiary_care_hospital"><span class="ds2-5-text-link__content">View PDF</span><span 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