BRCA2 germline mutations in familial pancreatic carcinoma

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BRCA2 mutation analysis should be included in molecular genetic testing and counseling strategies in families with at least two first-degree relatives affected with ductal …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/ed1a5a1f-b279-475e-88e3-75f261729818/core/no-script.css"> </noscript> <meta name="citation_title" content="BRCA2 germline mutations in familial pancreatic carcinoma"> <meta name="citation_authors" content="Hahn SA;Greenhalf B;Ellis I;Sina-Frey M;Rieder H;Korte B;Gerdes B;Kress R;Ziegler A;Raeburn JA;Campra D;Grützmann R;Rehder H;Rothmund M;Schmiegel W;Neoptolemos JP;Bartsch DK;"> <meta name="citation_date" content="02/05/2003"> <meta name="citation_publisher" content="J Natl Cancer Inst"> <meta name="citation_journal_title" content="Journal of the National Cancer Institute"> <meta name="citation_pmid" content="12569143"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/12569143/"> <meta name="citation_volume" content="95"> <meta name="citation_issue" content="3"> <meta name="citation_doi" content="10.1093/jnci/95.3.214"> <meta name="citation_issn" content="0027-8874"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/12569143/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="sRQlr55dQ3GOfzWokW90hPH19DT9GmWYngDXW8PgT1YHugdrD5uXnGr9ODofCEmk"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="sRQlr55dQ3GOfzWokW90hPH19DT9GmWYngDXW8PgT1YHugdrD5uXnGr9ODofCEmk"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="sRQlr55dQ3GOfzWokW90hPH19DT9GmWYngDXW8PgT1YHugdrD5uXnGr9ODofCEmk"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="sRQlr55dQ3GOfzWokW90hPH19DT9GmWYngDXW8PgT1YHugdrD5uXnGr9ODofCEmk"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="12569143"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/95.3.214" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=7898&itool=Abstract-def&log$=linkouticon&uid=12569143&db=pubmed&nlmid=7503089" title="See full text options at Silverchair Information Systems" data-ga-category="full_text" data-ga-action="Silverchair Information Systems" data-ga-label="12569143" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--academic.oup.com-images-oup_pubmed.png" alt="full text provider logo"><span class="text"> Silverchair Information Systems </span></a> </div> </div> <div class="short-view"> <a href="#" class="full-text-links-button full-text-links-dialog-trigger"> Full text links </a> </div> </div> <div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/12569143/citations/" data-citation-style="nlm" data-pubmed-format-link="/12569143/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="12569143" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger" aria-label="Save article in MyNCBI collections." data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_button" data-collections-open-dialog-enabled="false" data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F12569143%2F%23open-collections-dialog" data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog" class="dialog collections-dialog" aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="sRQlr55dQ3GOfzWokW90hPH19DT9GmWYngDXW8PgT1YHugdrD5uXnGr9ODofCEmk"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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</div> </aside> <main class="article-details" id="article-details">   <header class="heading" id="heading"> <div class="full-view" id="full-view-heading"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Journal of the National Cancer Institute" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Journal of the National Cancer Institute" data-pinger-ignore> J Natl Cancer Inst </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Journal of the National Cancer Institute"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22J+Natl+Cancer+Inst%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22J+Natl+Cancer+Inst%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=J Natl Cancer Inst" data-ga-category="search" data-ga-action="journal_link" data-ga-label="J Natl Cancer Inst"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Natl+Cancer+Inst%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="J Natl Cancer Inst"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Natl Cancer Inst"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Natl Cancer Inst"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2003 Feb 5;95(3):214-21.</span> </div> <span class="citation-doi"> doi: 10.1093/jnci/95.3.214. </span> </div> <h1 class="heading-title"> BRCA2 germline mutations in familial pancreatic carcinoma </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Hahn+SA&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Stephan A Hahn">Stephan A Hahn</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Germany." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Greenhalf+B&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bill Greenhalf">Bill Greenhalf</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ellis+I&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ian Ellis">Ian Ellis</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sina-Frey+M&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mercedes Sina-Frey">Mercedes Sina-Frey</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rieder+H&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Harald Rieder">Harald Rieder</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Korte+B&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Birgit Korte">Birgit Korte</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gerdes+B&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Berthold Gerdes">Berthold Gerdes</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kress+R&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ralf Kress">Ralf Kress</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ziegler+A&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Andreas Ziegler">Andreas Ziegler</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Raeburn+JA&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John A Raeburn">John A Raeburn</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Campra+D&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Donata Campra">Donata Campra</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gr%C3%BCtzmann+R&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Robert Grützmann">Robert Grützmann</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rehder+H&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Helga Rehder">Helga Rehder</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rothmund+M&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matthias Rothmund">Matthias Rothmund</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schmiegel+W&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wolff Schmiegel">Wolff Schmiegel</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Neoptolemos+JP&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John P Neoptolemos">John P Neoptolemos</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bartsch+DK&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Detlef K Bartsch">Detlef K Bartsch</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/12569143/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Germany.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">12569143</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1093/jnci/95.3.214&id_type=DOI" href="https://doi.org/10.1093/jnci/95.3.214" data-ga-category="full_text" data-ga-action="DOI" > 10.1093/jnci/95.3.214 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> BRCA2 germline mutations in familial pancreatic carcinoma </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Stephan A Hahn</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> J Natl Cancer Inst<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2003">2003</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/12569143/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="mobile-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> </div> <div class="extended-article-details" id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Journal of the National Cancer Institute" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Journal of the National Cancer Institute" data-pinger-ignore> J Natl Cancer Inst </button><div id="short-view-journal" 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class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Natl Cancer Inst"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Natl Cancer Inst"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2003 Feb 5;95(3):214-21.</span> </div> <span class="citation-doi"> doi: 10.1093/jnci/95.3.214. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Hahn+SA&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Stephan A Hahn">Stephan A Hahn</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Germany." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Greenhalf+B&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bill Greenhalf">Bill Greenhalf</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ellis+I&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ian Ellis">Ian Ellis</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sina-Frey+M&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mercedes Sina-Frey">Mercedes Sina-Frey</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rieder+H&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Harald Rieder">Harald Rieder</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Korte+B&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Birgit Korte">Birgit Korte</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gerdes+B&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Berthold Gerdes">Berthold Gerdes</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kress+R&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ralf Kress">Ralf Kress</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ziegler+A&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Andreas Ziegler">Andreas Ziegler</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Raeburn+JA&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John A Raeburn">John A Raeburn</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Campra+D&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Donata Campra">Donata Campra</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Gr%C3%BCtzmann+R&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Robert Grützmann">Robert Grützmann</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rehder+H&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Helga Rehder">Helga Rehder</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rothmund+M&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Matthias Rothmund">Matthias Rothmund</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schmiegel+W&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wolff Schmiegel">Wolff Schmiegel</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Neoptolemos+JP&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John P Neoptolemos">John P Neoptolemos</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bartsch+DK&cauthor_id=12569143" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Detlef K Bartsch">Detlef K Bartsch</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Germany.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">12569143</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1093/jnci/95.3.214&id_type=DOI" href="https://doi.org/10.1093/jnci/95.3.214" data-ga-category="full_text" data-ga-action="DOI" > 10.1093/jnci/95.3.214 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/12569143/citations/" data-citation-style="nlm" data-pubmed-format-link="/12569143/export/"><span 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<h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> <strong class="sub-title"> Background: </strong> Although as many as 10% of pancreatic cancer cases may have an inherited component, familial pancreatic cancer has not been linked to defects in any specific gene. Some studies have shown that families with germline mutations in the breast cancer susceptibility gene BRCA2 have an increased risk of breast and ovarian cancers, as well as a modestly increased risk of pancreatic cancer. To study these relationships in more detail, we examined whether BRCA2 germline mutations are associated with familial pancreatic cancer. </p> <p> <strong class="sub-title"> Methods: </strong> We identified 26 European families in which at least two first-degree relatives had a histologically confirmed diagnosis of pancreatic ductal adenocarcinoma. We sequenced genomic DNA isolated from peripheral blood lymphocytes obtained from participating family members to identify germline mutations in BRCA2. </p> <p> <strong class="sub-title"> Results: </strong> Three (12%, exact 95% confidence interval [CI] = 2% to 30%) families carried germline frameshift mutations in the BRCA2 gene that are predicted to result in a truncated BRCA2 protein. Two additional families harbored mutations previously designated as unclassified variants of BRCA2. Thus, 19% (exact 95% CI = 7% to 39%) of the families in our study had either a frameshift mutation or an unclassified variant of BRCA2. None of the families in our study met the criteria for familial breast or ovarian cancer. </p> <p> <strong class="sub-title"> Conclusions: </strong> Our data support an important role for BRCA2 germline mutations in a subpopulation of families with familial pancreatic cancer. BRCA2 mutation analysis should be included in molecular genetic testing and counseling strategies in families with at least two first-degree relatives affected with ductal adenocarcinoma of the pancreas. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="linked-articles" id="linked-commentary"> <h2 class="title"> Comment in </h2> <ul class="item-list usa-unstyled-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/12569133/" ref="article_id=12569133&linksrc=comments_link" data-ga-category="comment_correction" data-ga-action="abstract_page_link" data-ga-label="linked-commentary"> Familial pancreatic cancer: where are we in 2003? </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Petersen GM, Hruban RH.</span> <span class="docsum-authors short-authors">Petersen GM, et al.</span> <span class="docsum-journal-citation full-journal-citation">J Natl Cancer Inst. 2003 Feb 5;95(3):180-1. doi: 10.1093/jnci/95.3.180.</span> <span class="docsum-journal-citation short-journal-citation">J Natl Cancer Inst. 2003.</span> <span class="citation-part">PMID: <span class="docsum-pmid">12569133</span></span> <span class="no-abstract spaced-citation-item citation-part">No abstract available.</span> </div> </div> </li> </ul> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/26727920/" ref="article_id=26727920&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="26727920" data-ga-label=""> Statewide Retrospective Review of Familial Pancreatic Cancer in Delaware, and Frequency of Genetic Mutations in Pancreatic Cancer Kindreds. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Catts ZA, Baig MK, Milewski B, Keywan C, Guarino M, Petrelli N.</span> <span class="docsum-authors short-authors">Catts ZA, et al.</span> <span class="docsum-journal-citation full-journal-citation">Ann Surg Oncol. 2016 May;23(5):1729-35. doi: 10.1245/s10434-015-5026-x. 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class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Genes%2C+BRCA2%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Genes%2C+BRCA2%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Genes, BRCA2"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Genes, BRCA2*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Genes%2C+BRCA2" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Genes, BRCA2*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Genes, BRCA2"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Genes, BRCA2"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Genetic Predisposition to Disease" tabindex="0" aria-controls="keyword-actions-mesh-terms-7" aria-expanded="false" data-pinger-ignore> Genetic Predisposition to Disease </button><div id="keyword-actions-mesh-terms-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Genetic Predisposition to Disease"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Genetic+Predisposition+to+Disease%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Genetic+Predisposition+to+Disease%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Genetic Predisposition to Disease"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Genetic Predisposition to Disease"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Genetic+Predisposition+to+Disease" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Genetic Predisposition to Disease"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Genetic Predisposition to Disease"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Genetic Predisposition to Disease"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Germ-Line Mutation*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-8" aria-expanded="false" data-pinger-ignore> Germ-Line Mutation* </button><div id="keyword-actions-mesh-terms-major-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Germ-Line Mutation*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Germ-Line+Mutation%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Germ-Line+Mutation%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Germ-Line Mutation"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Germ-Line Mutation*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Germ-Line+Mutation" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Germ-Line Mutation*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Germ-Line Mutation"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Germ-Line Mutation"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Germany" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Germany </button><div id="keyword-actions-mesh-terms-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Germany"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Germany%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Germany%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Germany"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Germany"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Germany" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Germany"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Germany"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Germany"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-10" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Lymphocytes" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Lymphocytes </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Lymphocytes"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Lymphocytes%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Lymphocytes%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Lymphocytes"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Lymphocytes"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Lymphocytes" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Lymphocytes"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Lymphocytes"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Lymphocytes"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Male" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Male </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Male"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Male"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Male"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Male" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Male"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Male"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Male"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Middle Aged" tabindex="0" aria-controls="keyword-actions-mesh-terms-13" aria-expanded="false" data-pinger-ignore> Middle Aged </button><div id="keyword-actions-mesh-terms-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Middle Aged"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Middle Aged"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Middle Aged"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Pancreatic Neoplasms / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-14" aria-expanded="false" data-pinger-ignore> Pancreatic Neoplasms / genetics* </button><div id="keyword-actions-mesh-terms-major-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Pancreatic Neoplasms / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Pancreatic+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Pancreatic+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Pancreatic Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Pancreatic Neoplasms / genetics*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Pancreatic+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Pancreatic Neoplasms / genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pancreatic Neoplasms/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pancreatic Neoplasms/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Pedigree" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Pedigree </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Pedigree"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Pedigree%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Pedigree%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Pedigree"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Pedigree"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Pedigree" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Pedigree"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pedigree"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pedigree"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Phenotype" tabindex="0" aria-controls="keyword-actions-mesh-terms-16" aria-expanded="false" data-pinger-ignore> Phenotype </button><div id="keyword-actions-mesh-terms-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Phenotype"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Phenotype%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Phenotype%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Phenotype"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Phenotype"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Phenotype" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Phenotype"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Phenotype"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Phenotype"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Registries" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Registries </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Registries"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Registries%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Registries%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Registries"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Registries"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Registries" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Registries"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Registries"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Registries"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Sequence Analysis, DNA" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Sequence Analysis, DNA </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Sequence Analysis, DNA"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Sequence+Analysis%2C+DNA%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Sequence+Analysis%2C+DNA%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Sequence Analysis, DNA"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Sequence Analysis, DNA"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Sequence+Analysis%2C+DNA" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Sequence Analysis, DNA"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Sequence Analysis, DNA"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Sequence Analysis, DNA"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword DNA, Neoplasm" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> DNA, Neoplasm </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword DNA, Neoplasm"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22DNA%2C+Neoplasm%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22DNA%2C+Neoplasm%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="DNA, Neoplasm"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="DNA, Neoplasm"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22DNA%2C+Neoplasm%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="DNA, Neoplasm"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""DNA, Neoplasm"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""DNA, Neoplasm"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="related-links" class="related-links"> <h2 class="title"> 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BRCA2 germline mutations in familial pancreatic carcinoma - PubMed