CINXE.COM

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Ethos</a></li> <li class="leaf"><a href="/about-tocris/environment" id="main-menu-13876">Environment</a></li> <li class="last leaf"><a href="/about-tocris/careers-at-tocris" id="main-menu-13846">Careers</a></li> </ul></li> <li class="last leaf"><a href="/support/contact-us" id="main-menu-7501">Contact Us</a></li> </ul> </section> </div> </nav> </div> </header> <div class="breadcrumbs_wrapper"> <div class="breadcrumbs_container"> <div class="breadcrumb"><a href="/">Home</a> <span class="breadcrumb_separator">/</span> <a href="/resources">Resources</a> <span class="breadcrumb_separator">/</span> Tocris Blog</div> </div> </div> <div class="main-container container"> <a id="main-content"></a> <div class="row"> <div id="main_content" class="col-xs-12 col-sm-8 col-md-9 blog" itemscope itemtype="http://schema.org/Blog"> <h1>Tocris Blog</h1> <div> <div class="region region-content"> <section id="block-system-main" class="block block-system clearfix"> <div class="view view-blog view-id-blog view-display-id-page view-dom-id-b5cc54832d29b11faa103de5520c8c57"> <div class="view-header"> <p>Welcome to the Tocris blog! If you’re looking for fresh insights into new tools for life science research, or are interested in the latest news and events from Tocris then you’re in the right place. Read on to discover our latest content.</p> <p>If you would like to suggest a topic for our next blog post please fill in our <a href="/support/leave-feedback" title="Suggest a topic for our next blog post" rel="nofollow">feedback form</a>. </p><hr /> </div> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/opportunities-and-perspectives-design-and-synthesis-protac-degraders"><h2 itemprop="name headline">Opportunities and Perspectives on the Design and Synthesis of PROTAC® Degraders</h2></a> <time class="blog-item-date" itemprop="datePublished" content="July 5 2022">Tuesday, 05th July 2022</time> <div><a href="/resources/tocris-blog/opportunities-and-perspectives-design-and-synthesis-protac-degraders" title="Read about PROTAC Design and Synthesis"><img alt="Opportunities and Perspectives on the Design and Synthesis of PROTAC Degraders blog post" src="https://resources.tocris.com/images/blog/banners/protac-design-and-synthesis-banner.jpg" /></a></div> <p> </p> <h2>What is Targeted Protein Degradation?</h2> <p>Targeted Protein Degradation (TPD) broadly refers to strategies that re-...</p> <a href="/resources/tocris-blog/opportunities-and-perspectives-design-and-synthesis-protac-degraders" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-2 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/somatic-instability-and-huntingtons-disease"><h2 itemprop="name headline">Somatic Instability and Huntington's Disease</h2></a> <time class="blog-item-date" itemprop="datePublished" content="October 19 2021">Tuesday, 19th October 2021</time> <div><img alt="Huntington's disease and somatic instability blog post header banner" src="https://resources.tocris.com/images/blog/banners/somatic-instability-huntingtons-disease-banner.jpg" title="Read Somatic Instability and Huntington's Disease Blog Post" /></div> <p> </p> <h2>What is Huntington’s Disease?</h2> <p>Worldwide people are being diagnosed with the severe, but relatively rare, neurodegenerative disease called...</p> <a href="/resources/tocris-blog/somatic-instability-and-huntingtons-disease" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-3 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/development-kras-targeting-protac"><h2 itemprop="name headline">Development of a KRAS-Targeting PROTAC</h2></a> <time class="blog-item-date" itemprop="datePublished" content="August 16 2021">Monday, 16th August 2021</time> <div><img alt="Development of a KRAS Targeting PROTAC Banner" src="https://resources.tocris.com/images/blog/banners/lc-2-blog-banner.jpg" title="Development of a KRAS Targeting PROTAC Blog Post" /></div> <p> </p> <p>In this question-and-answer session, Michael Bond (Yale University) talks to our Senior Product Specialist, Alex Moloney PhD, about the development of LC 2, a KRAS G12C-targeting PROTAC<sup>®</sup> which is now <a href="/products/lc-2_7420" title="Learn more about LC 2">available...</a></p> <a href="/resources/tocris-blog/development-kras-targeting-protac" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-4 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/regenerative-medicine-bench-clinic"><h2 itemprop="name headline">Regenerative Medicine - From Bench to Clinic</h2></a> <time class="blog-item-date" itemprop="datePublished" content="July 27 2021">Tuesday, 27th July 2021</time> <div><img alt="Regenerative Medicine: From Bench to Clinic Banner" src="https://resources.tocris.com/images/blog/banners/regenerative-medicine-blog-banner.jpg" title="Regenerative Medicine: Translation From Bench to Clinic Banner" /></div> <p> </p> <p>In June 2021, BlueRock Therapeutics announced that the first patient had been dosed in a phase I trial of a new cell therapy for the treatment of...</p> <a href="/resources/tocris-blog/regenerative-medicine-bench-clinic" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-5 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/cerebral-organoids-neurodevelopment-neurodegeneration-virology-research"><h2 itemprop="name headline">Cerebral Organoids in Neurodevelopment, Neurodegeneration & Virology Research</h2></a> <time class="blog-item-date" itemprop="datePublished" content="February 22 2021">Monday, 22nd February 2021</time> <div><img alt="Cerebral Organoids in Neurodevelopment, Neurodegeneration and Virology Research" src="https://resources.tocris.com/images/blog/banners/cerebral-organoids-blog-header.jpg" title="Cerebral Organoids in Neurodevelopment, Neurodegeneration and Virology Research" /></div> <p> </p> <h2>What are Cerebral Organoids?</h2> <p>Cerebral <a href="/cell-biology/organoids" title="Browse Products for Organoids">organoids</a>, also called brain organoids, are miniature organs artificially...</p> <a href="/resources/tocris-blog/cerebral-organoids-neurodevelopment-neurodegeneration-virology-research" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-6 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/sars-cov-2-update-key-targets-trends-and-discoveries"><h2 itemprop="name headline">SARS-CoV-2: An Update on Key Targets, Trends and Discoveries </h2></a> <time class="blog-item-date" itemprop="datePublished" content="December 15 2020">Tuesday, 15th December 2020</time> <div><img alt="An update of key targets, trends and discoveries in SARS-CoV-2 Research" src="https://resources.tocris.com/images/blog/banners/sars-cov-2-update-blog-2.jpg" title=" an update of key targets, trends and discoveries" /></div> <p> </p> <p>Since the emergence of SARS-CoV-2 the effort among researchers finding ways to stop the virus has been unprecedented. Huge advances have been made in our knowledge of both the virus (SARS-CoV-2) and associated disease (...</p> <a href="/resources/tocris-blog/sars-cov-2-update-key-targets-trends-and-discoveries" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-7 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/how-use-bioactive-compound-library"><h2 itemprop="name headline">How To Use A Bioactive Compound Library</h2></a> <time class="blog-item-date" itemprop="datePublished" content="October 9 2020">Friday, 09th October 2020</time> <div class="blog-image-border"><img alt="How to use a Bioactive Compound Library" src="https://resources.tocris.com/images/blog/banners/header-compound-library-845x150.png" title="How to use a Bioactive Compound Library" /></div> <p><a href="/product-type/tocriscreen-compound-libraries" target="_blank">Bioactive compound libraries</a> are composed of small molecules and can be used for high-throughput screening in biomedical research, medicinal chemistry and chemical biology. These screening...</p> <a href="/resources/tocris-blog/how-use-bioactive-compound-library" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-8 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/new-uses-organoids"><h2 itemprop="name headline">New Uses for Organoids </h2></a> <time class="blog-item-date" itemprop="datePublished" content="August 27 2020">Thursday, 27th August 2020</time> <div class="blog-image-border"><img alt="New uses for organoids in drug development and medicine" src="https://resources.tocris.com/images/blog/banners/organoids-blog-header.jpg" title="New uses for organoids in drug development and medicine" /></div> <h3>Why Organoids?</h3> <p>The lack of suitable <em>in vitro</em> models that accurately represent specific tissues and disease states is a significant hindrance to basic and translational research. This has led to the development of 3D...</p> <a href="/resources/tocris-blog/new-uses-organoids" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-9 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/existing-drugs-targeting-sars-cov-2-and-coronaviruses"><h2 itemprop="name headline">Existing Drugs Targeting SARS-CoV-2 and Coronaviruses</h2></a> <time class="blog-item-date" itemprop="datePublished" content="April 20 2020">Monday, 20th April 2020</time> <div><img alt="Existing Drugs Targeting SARS-CoV-2 and Coronaviruses" src="https://resources.tocris.com/images/blog/banners/coronavirus-blog-post-header-845x150.png" title="Existing Drugs Targeting SARS-CoV-2 and Coronaviruses" /></div> <p><em>All Tocris products mentioned in this blog post are for biomedical research use only. They are not intended for human or veterinary use.</em></p> <p>The coronavirus family, named for their crown-like shape, cause...</p> <a href="/resources/tocris-blog/existing-drugs-targeting-sars-cov-2-and-coronaviruses" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-10 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/gmp-ancillary-materials-importance-stem-cell-therapy-manufacture"><h2 itemprop="name headline">GMP Ancillary Materials: Importance for Stem Cell Therapy Manufacture</h2></a> <time class="blog-item-date" itemprop="datePublished" content="September 11 2019">Wednesday, 11th September 2019</time> <div class="blog-image-border"><img alt="Importance of GMP Ancillary Reagents for Stem Cell Therapy Manufacture" src="https://resources.tocris.com/images/blog/banners/importance-of-gmp-reagents-for-stem-cell-therapy-banner-v2.jpg" title=" Importance for Stem Cell Therapy Manufacture" /></div> <h3>Ancillary Materials for Stem Cell Therapy</h3> <p>Stem cell therapies offer great potential for the treatment of several pathologies, including Parkinson’s disease, diabetes, and heart disease. The...</p> <a href="/resources/tocris-blog/gmp-ancillary-materials-importance-stem-cell-therapy-manufacture" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-11 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/rock-inhibitor-stem-cell-cryopreservation"><h2 itemprop="name headline">ROCK Inhibitor for Stem Cell Cryopreservation</h2></a> <time class="blog-item-date" itemprop="datePublished" content="August 8 2019">Thursday, 08th August 2019</time> <div class="blog-image-border"><img alt="ROCK inhibitor for cryopreservation of stem cells" src="https://resources.tocris.com/images/blog/banners/rock-inhibitor-cryopreservation-stem-cells.jpg" title="ROCK inhibitor for cryopreservation of stem cells" /></div> <p>The ROCK inhibitor, Y-27632, protects stem cells from dissociation-associated apoptosis during cryopreservation and increases cell viability post-thawing. This blog post discusses why the ROCK inhibitor is required, provides evidence...</p> <a href="/resources/tocris-blog/rock-inhibitor-stem-cell-cryopreservation" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-12 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/celebrating-25-years-tocris-cookson"><h2 itemprop="name headline">Celebrating 25 Years of Tocris Cookson</h2></a> <time class="blog-item-date" itemprop="datePublished" content="July 16 2019">Tuesday, 16th July 2019</time> <div class="blog-image-border"><img alt="Celebrating 25 Years of Tocris Cookson" itemprop="image" src="https://resources.tocris.com/images/blog/banners/celebrating-25-years-of-tocris-cookson-blog.jpg?v=1" title="Celebrating 25 Years of Tocris Cookson" /></div> <p>Twenty five years ago, Tocris Neuramin and Cookson Chemicals merged to form Tocris Cookson, which remains our trading name to this day. Since then, Tocris has provided the life science community with the latest and most innovative...</p> <a href="/resources/tocris-blog/celebrating-25-years-tocris-cookson" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-13 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/dtag-protein-degradation-platform-target-validation"><h2 itemprop="name headline">dTAG - A Protein Degradation Platform for Target Validation</h2></a> <time class="blog-item-date" itemprop="datePublished" content="July 9 2019">Tuesday, 09th July 2019</time> <div class="blog-image-border"><img alt="dTAG - A protein degradation platform for target validation" src="https://resources.tocris.com/images/blog/banners/dtag-protein-degradation-for-target-validation.jpg" title="dTAG - A protein degradation platform for target validation" /></div> <h3>What is dTAG?</h3> <p>dTAG (degradation TAG) is an innovative approach to target validation, using heterobifunctional small molecule Degraders to harness a cell’s protein degradation system and eliminate a...</p> <a href="/resources/tocris-blog/dtag-protein-degradation-platform-target-validation" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-14 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/applications-epigenetic-chemical-probes-non-oncology-research"><h2 itemprop="name headline">Applications for Epigenetic Chemical Probes in Non-Oncology Research</h2></a> <time class="blog-item-date" itemprop="datePublished" content="November 22 2018">Thursday, 22nd November 2018</time> <div class="blog-image-border"><img alt="Potential Applications for Epigenetic Chemical Probes in Non-Oncology Research" itemprop="image" src="https://resources.tocris.com/images/blog/banners/epigenetic-probes-non-oncology-research.jpg" title="Potential Applications for Epigenetic Chemical Probes in Non-Oncology Research" /></div> <p><a href="/cell-biology/epigenetics" target="_blank">Epigenetic</a> chemical probes are well established tools in oncology research but their application to other...</p> <a href="/resources/tocris-blog/applications-epigenetic-chemical-probes-non-oncology-research" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-15 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/using-chemical-probes-brief-guide"><h2 itemprop="name headline">Using Chemical Probes – A Brief Guide</h2></a> <time class="blog-item-date" itemprop="datePublished" content="June 15 2018">Friday, 15th June 2018</time> <div class="blog-image-border"><img alt="Using Chemical Probes" itemprop="image" src="https://resources.tocris.com/images/blog/banners/using-chemical-probes-guide.jpg" title="Using Chemical Probes" /></div> <p>With such a high level of discussion around the reproducibility of experiments described in the peer-reviewed literature, it is becoming increasingly prudent to scrutinize the tools that we use to conduct our research. Selecting a “good” probe is key to generating reliable and...</p> <a href="/resources/tocris-blog/using-chemical-probes-brief-guide" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-16 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/developing-chemical-probes-epigenetic-targets"><h2 itemprop="name headline">Developing Chemical Probes for Epigenetic Targets</h2></a> <time class="blog-item-date" itemprop="datePublished" content="April 13 2018">Friday, 13th April 2018</time> <div class="blog-image-border"><img alt="Developing Chemical Probes for Epigenetic Targets" itemprop="image" src="https://resources.tocris.com/images/blog/banners/chemical-probes-for-epigenetic-targets.jpg" title="Developing Chemical Probes for Epigenetic Targets" /></div> <p>The Structural Genomics Consortium (SGC) was set-up in 2004, with the goal of solving the protein structures of relevance to human disease. Since then the mission has expanded to advancing drug discovery via open access...</p> <a href="/resources/tocris-blog/developing-chemical-probes-epigenetic-targets" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-17 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/small-molecules-immune-system-cancer"><h2 itemprop="name headline">Targeting the Immune System in Cancer with Small Molecules</h2></a> <time class="blog-item-date" itemprop="datePublished" content="April 3 2018">Tuesday, 03rd April 2018</time> <div class="blog-image-border"><img alt="Small Molecules for Immuno-oncology" itemprop="image" src="https://resources.tocris.com/images/blog/banners/small-molecules-for-immuno-oncology.jpg" title="Small Molecules for Immuno-oncology" /></div> <p>Recent clinical successes in targeting the immune system for the treatment of cancer have harnessed biologicals, including antibodies, proteins, engineered cells and oncolytic viruses. Small molecules directed at the immune system offer advantages over...</p> <a href="/resources/tocris-blog/small-molecules-immune-system-cancer" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-18 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/five-reasons-use-small-molecules-stem-cell-research"><h2 itemprop="name headline">Five Reasons to use Small Molecules in Stem Cell Research</h2></a> <time class="blog-item-date" itemprop="datePublished" content="February 15 2018">Thursday, 15th February 2018</time> <div class="blog-image-border"><img alt="Small Molecules for Stem Cell Research" itemprop="image" src="https://resources.tocris.com/images/blog/banners/small-molecules-stem-cell-research.jpg?v=2" title="Five reasons to use Small Molecules in Stem Cell Research" /></div> <p><a href="/cell-biology/stem-cells" target="_blank">Stem cells</a> are defined by their ability to differentiate into specialized cells and to self-renew. Pluripotent stem cells (PSCs), of which embryonic stem cells (ESCs)...</p> <a href="/resources/tocris-blog/five-reasons-use-small-molecules-stem-cell-research" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-19 views-row-odd"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/small-molecules-neural-induction-stem-cells"><h2 itemprop="name headline">Small Molecules for Neural Induction of Stem Cells</h2></a> <time class="blog-item-date" itemprop="datePublished" content="January 25 2018">Thursday, 25th January 2018</time> <div class="blog-image-border"><img alt="Small Molecules for Neural Induction of Stem Cells" itemprop="image" src="https://resources.tocris.com/images/blog/banners/neural-differentiation-of-stem-cells.jpg" title="Small Molecules for Neural Induction of Stem Cells" /></div> <p>Differentiation of <a href="/cell-biology/escs-and-ipscs" target="_blank">human induced pluripotent stem cells</a> (hiPSCs) into functional neurons is an exciting area of research, with considerable therapeutic potential...</p> <a href="/resources/tocris-blog/small-molecules-neural-induction-stem-cells" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-20 views-row-even"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/tocris-blog/ras-the-undruggable-target"><h2 itemprop="name headline">RAS - The Undruggable Target</h2></a> <time class="blog-item-date" itemprop="datePublished" content="November 24 2017">Friday, 24th November 2017</time> <div class="blog-image-border"><img alt="blog banner : RAS - The Undruggable Target" itemprop="image" src="https://resources.tocris.com/images/blog/banners/therapeutic-vulnerabilities-of-ras-oncoproteins.jpg" title="RAS - The Undruggable Target" /></div> <p>Long-termed the “undruggable target”, RAS has recently recaptured the attention of cancer researchers. A new understanding of this target has once again reignited hopes of modulating it to tackle some of the most lethal cancers.</p> <p>...</p> <a href="/resources/tocris-blog/ras-the-undruggable-target" class="btn btn-primary">Read more</a> </article> </span> </div> </div> <div class="views-row views-row-21 views-row-odd views-row-last"> <div class="views-field views-field-nothing"> <span class="field-content"><article> <a href="/resources/blog/new-fluorescent-dyes-for-super-resolution-micropscopy"><h2 itemprop="name headline">New Fluorescent Dyes for Super-resolution Microscopy</h2></a> <time class="blog-item-date" itemprop="datePublished" content="November 23 2017">Thursday, 23rd November 2017</time> <div class="blog-image"><img alt="blog banner : New Fluorescent Dyes for Super-resolution Microscopy" itemprop="image" src="https://resources.tocris.com/images/blog/banners/janelia-fluor-dyes-for-super-resolution-microscopy.jpg" title="New Fluorescent Dyes for Super-resolution Microscopy" /></div> <p><a href="/product-type/fluorescence-imaging" target="_blank">Fluorescence imaging</a> is an essential tool in biological research, which enables the visualization of proteins in live and fixed...</p> <a href="/resources/blog/new-fluorescent-dyes-for-super-resolution-micropscopy" class="btn btn-primary">Read more</a> </article> </span> </div> </div> </div> </div> </section> <section id="block-block-16" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext" style="height:48px;"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div 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