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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">IDH3G</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">IDH3G</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/5386">IDH3G</a></span>, H-IDHG, isocitrate dehydrogenase 3 (NAD(+)) gamma, isocitrate dehydrogenase (NAD(+)) 3 gamma, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/300089">300089</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1099463">1099463</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=55803">55803</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=IDH3G">IDH3G</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000067829">IDH3G - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_X.svg" class="mw-file-description" title="X chromosome (human)"><img alt="X chromosome (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/300px-Ideogram_human_chromosome_X.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/450px-Ideogram_human_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/600px-Ideogram_human_chromosome_X.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/X_chromosome_(human)" class="mw-redirect" title="X chromosome (human)">X chromosome (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_X_ideogram.svg" class="mw-file-description" title="X chromosome (human)"><img alt="X chromosome (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/300px-Human_chromosome_X_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/450px-Human_chromosome_X_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/600px-Human_chromosome_X_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 284.49058100772px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for IDH3G"><img alt="Genomic location for IDH3G" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 290.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for IDH3G"><img alt="Genomic location for IDH3G" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Xq28</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">153,785,766 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">153,794,512 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_X.svg" class="mw-file-description" title="X chromosome (mouse)"><img alt="X chromosome (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/260px-Ideogram_house_mouse_chromosome_X.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/390px-Ideogram_house_mouse_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/520px-Ideogram_house_mouse_chromosome_X.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">X chromosome (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_X.svg" class="mw-file-description" title="X chromosome (mouse)"><img alt="X chromosome (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/300px-Ideogram_of_house_mouse_chromosome_X.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/450px-Ideogram_of_house_mouse_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/600px-Ideogram_of_house_mouse_chromosome_X.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 119.84433950885px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for IDH3G"><img alt="Genomic location for IDH3G" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 125.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for IDH3G"><img alt="Genomic location for IDH3G" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">X A7.3|X 37.41 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">72,822,569 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">72,830,503 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000067829">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right hemisphere of cerebellum</li><br /><li style="line-height: 137%;">gastric mucosa</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">apex of heart</li><br /><li style="line-height: 137%;">right auricle</li><br /><li style="line-height: 137%;">left adrenal gland</li><br /><li style="line-height: 137%;">right adrenal gland</li><br /><li style="line-height: 137%;">left adrenal cortex</li><br /><li style="line-height: 137%;">right adrenal cortex</li><br /><li style="line-height: 137%;">muscle of thigh</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000002010">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">cardiac muscle tissue of left ventricle</li><br /><li style="line-height: 137%;">brown adipose tissue</li><br /><li style="line-height: 137%;">interventricular septum</li><br /><li style="line-height: 137%;">thoracic diaphragm</li><br /><li style="line-height: 137%;">right ventricle</li><br /><li style="line-height: 137%;">sternocleidomastoid muscle</li><br /><li style="line-height: 137%;">temporal muscle</li><br /><li style="line-height: 137%;">tibialis anterior muscle</li><br /><li style="line-height: 137%;">masseter muscle</li><br /><li style="line-height: 137%;">digastric muscle</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000067829">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_IDH3G_214333_x_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PBB_GE_IDH3G_214333_x_at_fs.png/250px-PBB_GE_IDH3G_214333_x_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PBB_GE_IDH3G_214333_x_at_fs.png/375px-PBB_GE_IDH3G_214333_x_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PBB_GE_IDH3G_214333_x_at_fs.png/500px-PBB_GE_IDH3G_214333_x_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_IDH3G_202471_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/68/PBB_GE_IDH3G_202471_s_at_fs.png/250px-PBB_GE_IDH3G_202471_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/68/PBB_GE_IDH3G_202471_s_at_fs.png/375px-PBB_GE_IDH3G_202471_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/68/PBB_GE_IDH3G_202471_s_at_fs.png/500px-PBB_GE_IDH3G_202471_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/3421/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005524">ATP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051287">NAD binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016616">oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000287">magnesium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004449">isocitrate dehydrogenase (NAD+) activity</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005759">mitochondrial matrix</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005739">mitochondrion</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006099">tricarboxylic acid cycle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006102">isocitrate metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005975">carbohydrate metabolic process</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3421&rn=1">3421</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=15929&rn=1">15929</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000067829;db=core">ENSG00000067829</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000002010;db=core">ENSMUSG00000002010</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P51553">P51553</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P70404">P70404</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_174869">NM_174869</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004135">NM_004135</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008323">NM_008323</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001356356">NM_001356356</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004126">NP_004126</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_777358">NP_777358</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032349">NP_032349</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001343285">NP_001343285</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chrX:153785766-153794512">Chr X: 153.79 – 153.79 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chrX:72822569-72830503">Chr X: 72.82 – 72.83 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18027557" class="extiw" title="d:Q18027557">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18251408" class="extiw" title="d:Q18251408">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>IDH3G</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid9286695_5-0" class="reference"><a href="#cite_note-pmid9286695-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Isocitrate_dehydrogenase" title="Isocitrate dehydrogenase">Isocitrate dehydrogenases</a> (IDHs) <a href="/wiki/Catalyze" class="mw-redirect" title="Catalyze">catalyze</a> the oxidative de<a href="/wiki/Carboxylation" title="Carboxylation">carboxylation</a> of <a href="/wiki/Isocitrate" class="mw-redirect" title="Isocitrate">isocitrate</a> to <a href="/wiki/2-oxoglutarate" class="mw-redirect" title="2-oxoglutarate">2-oxoglutarate</a>. These enzymes belong to two distinct subclasses, one of which utilizes <a href="/wiki/Nicotinamide_adenine_dinucleotide" title="Nicotinamide adenine dinucleotide">NAD</a>(+) as the <a href="/wiki/Electron_acceptor" title="Electron acceptor">electron acceptor</a> and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two <a href="/wiki/NADP" class="mw-redirect" title="NADP">NADP</a>(+)-dependent isocitrate dehydrogenases, one of which is <a href="/wiki/Mitochondria" class="mw-redirect" title="Mitochondria">mitochondrial</a> and the other predominantly <a href="/wiki/Cytosol" title="Cytosol">cytosolic</a>. NAD(+)-dependent isocitrate dehydrogenases catalyze the <a href="/wiki/Allosteric_regulation" title="Allosteric regulation">allosterically regulated</a> <a href="/wiki/Rate-limiting_step" class="mw-redirect" title="Rate-limiting step">rate-limiting step</a> of the <a href="/wiki/Tricarboxylic_acid_cycle" class="mw-redirect" title="Tricarboxylic acid cycle">tricarboxylic acid cycle</a>. Each isozyme is a <a href="/wiki/Heterotetramer" class="mw-redirect" title="Heterotetramer">heterotetramer</a> that is composed of two alpha <a href="/wiki/Protein_subunit" title="Protein subunit">subunits</a>, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for <a href="/wiki/Ventricular_system" title="Ventricular system">periventricular</a> <a href="/wiki/Heterotopia_(medicine)" title="Heterotopia (medicine)">heterotopia</a>. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]<sup id="cite_ref-entrez_6-1" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IDH3 is one of three isocitrate dehydrogenase isozymes, the other two being <a href="/wiki/IDH1" class="mw-redirect" title="IDH1">IDH1</a> and <a href="/wiki/IDH2" title="IDH2">IDH2</a>, and encoded by one of five isocitrate dehydrogenase genes, which are <i>IDH1</i>, <i><a href="/wiki/IDH2" title="IDH2">IDH2</a></i>, <i><a href="/wiki/IDH3A" title="IDH3A">IDH3A</a></i>, <i><a href="/wiki/IDH3B" title="IDH3B">IDH3B</a></i>, and <i>IDH3G</i>.<sup id="cite_ref-pmid25678837_7-0" class="reference"><a href="#cite_note-pmid25678837-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The genes <i>IDH3A</i>, <i>IDH3B</i>, and <i>IDH3G</i> encode subunits of IDH3, which is a <a href="/wiki/Heterotetramer" class="mw-redirect" title="Heterotetramer">heterotetramer</a> composed of two 37-kDa α subunits (IDH3α), one 39-kDa β subunit (IDH3β), and one 39-kDa γ subunit (IDH3γ), each with distinct <a href="/wiki/Isoelectric_point" title="Isoelectric point">isoelectric points</a>.<sup id="cite_ref-pmid25531325_8-0" class="reference"><a href="#cite_note-pmid25531325-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17432878_9-0" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16737955_10-0" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Alignment of their <a href="/wiki/Amino_acid_sequence" class="mw-redirect" title="Amino acid sequence">amino acid sequences</a> reveals ~40% identity between IDH3α and IDH3β, ~42% identity between IDH3α and IDH3γ, and an even closer identity of 53% between IDH3β and IDH3γ, for an overall 34% identity and 23% similarity across all three subunit types.<sup id="cite_ref-pmid17432878_9-1" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16737955_10-1" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14555658_11-0" class="reference"><a href="#cite_note-pmid14555658-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid20435888_12-0" class="reference"><a href="#cite_note-pmid20435888-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Notably, <a href="/wiki/Arginine" title="Arginine">Arg</a>88 in IDH3α is essential for IDH3 catalytic activity, whereas the equivalent Arg99 in IDH3β and Arg97 in IDH3γ are largely involved in the enzyme's allosteric regulation by ADP and NAD.<sup id="cite_ref-pmid14555658_11-1" class="reference"><a href="#cite_note-pmid14555658-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Thus, it is possible that these subunits arose from <a href="/wiki/Gene_duplication" title="Gene duplication">gene duplication</a> of a common ancestral gene, and the original catalytic Arg <a href="/wiki/Amino_acid" title="Amino acid">residue</a> were adapted to allosteric functions in the β- and γ-subunits.<sup id="cite_ref-pmid17432878_9-2" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14555658_11-2" class="reference"><a href="#cite_note-pmid14555658-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Likewise, <a href="/wiki/Aspartic_acid" title="Aspartic acid">Asp</a>181 in IDH3α is essential for catalysis, while the equivalent Asp192 in IDH3β and Asp190 in IDH3γ enhance NAD- and Mn<sup>2+</sup>-binding.<sup id="cite_ref-pmid17432878_9-3" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Since the oxidative decarboxylation catalyzed by IDH3 requires binding of NAD, Mn<sup>2+</sup>, and the <a href="/wiki/Substrate_(biochemistry)" class="mw-redirect" title="Substrate (biochemistry)">substrate</a> isocitrate, all three subunits participate in the catalytic reaction.<sup id="cite_ref-pmid16737955_10-2" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14555658_11-3" class="reference"><a href="#cite_note-pmid14555658-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Moreover, studies of the enzyme in pig heart reveal that the αβ and αγ dimers constitute two binding sites for each of its <a href="/wiki/Ligand" title="Ligand">ligands</a>, including isocitrate, Mn<sup>2+</sup>, and NAD, in one IDH3 tetramer.<sup id="cite_ref-pmid17432878_9-4" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16737955_10-3" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>As an isocitrate dehydrogenase, IDH3 catalyzes the irreversible oxidative decarboxylation of isocitrate to yield <a href="/wiki/%CE%91-ketoglutarate" class="mw-redirect" title="Α-ketoglutarate">α-ketoglutarate</a> (α-KG) and CO<sub>2</sub> as part of the <a href="/wiki/Tricarboxylic_acid_cycle" class="mw-redirect" title="Tricarboxylic acid cycle">TCA cycle</a> in glucose metabolism.<sup id="cite_ref-pmid25531325_8-1" class="reference"><a href="#cite_note-pmid25531325-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17432878_9-5" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16737955_10-4" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14555658_11-4" class="reference"><a href="#cite_note-pmid14555658-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8833160_13-0" class="reference"><a href="#cite_note-pmid8833160-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> This step also allows for the concomitant <a href="/wiki/Organic_redox_reaction" title="Organic redox reaction">reduction</a> of NAD+ to NADH, which is then used to generate <a href="/wiki/Adenosine_triphosphate" title="Adenosine triphosphate">ATP</a> through the <a href="/wiki/Electron_transport_chain" title="Electron transport chain">electron transport chain</a>. Notably, IDH3 relies on NAD+ as its <a href="/wiki/Electron_acceptor" title="Electron acceptor">electron acceptor</a>, as opposed to NADP+ like IDH1 and IDH2.<sup id="cite_ref-pmid25531325_8-2" class="reference"><a href="#cite_note-pmid25531325-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17432878_9-6" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> IDH3 activity is regulated by the energy needs of the cell: when the cell requires energy, IDH3 is activated by ADP; and when energy is no longer required, IDH3 is inhibited by ATP and NADH.<sup id="cite_ref-pmid17432878_9-7" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16737955_10-5" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> This allosteric regulation allows IDH3 to function as a rate-limiting step in the TCA cycle.<sup id="cite_ref-pmid8833160_13-1" class="reference"><a href="#cite_note-pmid8833160-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid26782057_14-0" class="reference"><a href="#cite_note-pmid26782057-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Within cells, IDH3 and its subunits have been observed to <a href="/wiki/Subcellular_localization" title="Subcellular localization">localize</a> to the <a href="/wiki/Mitochondria" class="mw-redirect" title="Mitochondria">mitochondria</a>.<sup id="cite_ref-pmid17432878_9-8" class="reference"><a href="#cite_note-pmid17432878-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16737955_10-6" class="reference"><a href="#cite_note-pmid16737955-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8833160_13-2" class="reference"><a href="#cite_note-pmid8833160-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_Significance">Clinical Significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=3" title="Edit section: Clinical Significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <i>IDH3G</i> gene may be involved in drug resistance in <a href="/wiki/Gastric_cancer" class="mw-redirect" title="Gastric cancer">gastric cancer</a>.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactive_pathway_map">Interactive pathway map</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=4" title="Edit section: Interactive pathway map"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>Click on genes, proteins and metabolites below to link to respective articles.</i> <sup id="cite_ref-WikiPathways_16-0" class="reference"><a href="#cite_note-WikiPathways-16"><span class="cite-bracket">[</span>§ 1<span class="cite-bracket">]</span></a></sup> </p> <div style="overflow:auto;"> <div class="thumb tleft"> <div class="thumbinner" style="width: 377px;"> <div class="thumbimage" style="width: 375px; height: 350px; overflow: hidden;"> <div style="position: relative; top: -354.66454229291px; left: -610px; width: {{{bSize}}}px"><div class="noresize">[[File:<div class="noresize thumb tnone" style=";"> <div class="thumbinner" style="overflow:hidden;width:977px;"> <div class="thumbimage" style="overflow:hidden; 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href="/wiki/Guanosine_triphosphate" shape="rect" coords="211,619,241,633" alt="Go to article" title="Go to article" /><area href="/wiki/Guanosine_diphosphate" shape="rect" coords="452,726,483,740" alt="Go to article" title="Go to article" /><area href="/wiki/Carbon_dioxide" shape="rect" coords="819,516,848,531" alt="Go to article" title="Go to article" /><area href="/wiki/Water" shape="rect" coords="571,283,613,297" alt="Go to article" title="Go to article" /><area rel="nofollow" href="http://www.hmdb.ca/metabolites/HMDB0001487" class="plainlinks" shape="rect" coords="351,310,384,325" alt="Go to HMDB" title="Go to HMDB" /><area href="/wiki/Oxaloacetic_acid" shape="rect" coords="277,273,359,293" alt="Go to article" title="Go to article" /><area href="/wiki/IDH3B" shape="rect" coords="864,475,924,495" alt="Go to article" title="Go to article" /><area href="/wiki/Coenzyme_Q10" shape="rect" coords="316,538,387,552" alt="Go to article" title="Go to article" /><area rel="nofollow" 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coords="720,677,780,697" alt="Go to article" title="Go to article" /><area href="/wiki/Succinic_acid" shape="rect" coords="281,565,355,585" alt="Go to article" title="Go to article" /><area href="/wiki/Adenosine_triphosphate" shape="rect" coords="403,563,433,577" alt="Go to article" title="Go to article" /><area href="/wiki/IDH3G" shape="rect" coords="864,495,924,515" alt="Go to article" title="Go to article" /><area href="/wiki/Succinate_dehydrogenase_complex_subunit_C" shape="rect" coords="60,526,120,546" alt="Go to article" title="Go to article" /><area href="/wiki/ACO2" shape="rect" coords="798,343,844,363" alt="Go to article" title="Go to article" /><area href="/wiki/Coenzyme_A" shape="rect" coords="431,173,460,187" alt="Go to article" title="Go to article" /><area href="/wiki/Nicotinamide_adenine_dinucleotide" shape="rect" coords="220,339,250,353" alt="Go to article" title="Go to article" /><area href="/wiki/Acetyl-CoA" shape="rect" coords="258,203,331,223" alt="Go to article" title="Go to article" /><area href="/wiki/Alpha-Ketoglutaric_acid" shape="rect" coords="690,571,775,591" alt="Go to article" title="Go to article" /><area href="/wiki/IDH2" shape="rect" coords="664,474,709,494" alt="Go to article" title="Go to article" /><area href="/wiki/SDHD" shape="rect" coords="60,546,120,566" alt="Go to article" title="Go to article" /><area rel="nofollow" href="http://www.wikipathways.org/index.php/Pathway:WP111" class="plainlinks" shape="rect" coords="104,666,279,686" alt="Go to WikiPathways" title="Go to WikiPathways" /><area href="/wiki/Coenzyme_A" shape="rect" coords="211,604,241,619" alt="Go to article" title="Go to article" /><area href="/wiki/SDHB" shape="rect" coords="60,506,120,526" alt="Go to article" title="Go to article" /><area href="/wiki/Adenosine_diphosphate" shape="rect" coords="514,602,545,616" alt="Go to article" title="Go to article" /><area rel="nofollow" href="http://www.hmdb.ca/metabolites/HMDB0000221" class="plainlinks" shape="rect" coords="657,533,700,547" alt="Go to HMDB" title="Go to HMDB" /><area href="/wiki/Citrate_synthase" shape="rect" coords="368,171,401,191" alt="Go to article" title="Go to article" /><area href="/wiki/Citric_acid" shape="rect" coords="495,193,548,213" alt="Go to article" title="Go to article" /><area href="/wiki/Coenzyme_A" shape="rect" coords="647,593,675,607" alt="Go to article" title="Go to article" /><area href="/wiki/Nicotinamide_adenine_dinucleotide" shape="rect" coords="815,430,854,444" alt="Go to article" title="Go to article" /><area href="/wiki/IDH3A" shape="rect" coords="864,455,924,475" alt="Go to article" title="Go to article" /><area rel="nofollow" href="http://www.wikipathways.org/index.php/Pathway:WP497" class="plainlinks" shape="rect" coords="90,450,180,470" alt="Go to WikiPathways" title="Go to WikiPathways" /><area href="/wiki/Dihydrolipoamide_dehydrogenase" shape="rect" coords="720,697,780,717" alt="Go to article" title="Go to article" /><area rel="nofollow" href="http://www.wikipathways.org/index.php/Pathway:WP357" class="plainlinks" shape="rect" coords="551,115,705,135" alt="Go to WikiPathways" title="Go to WikiPathways" /><area rel="nofollow" href="http://www.hmdb.ca/metabolites/HMDB0001487" class="plainlinks" shape="rect" coords="818,537,854,551" alt="Go to HMDB" title="Go to HMDB" /><area href="/wiki/OGDH" shape="rect" coords="720,657,780,677" alt="Go to article" title="Go to article" /><area rel="nofollow" href="http://www.wikipathways.org/index.php/Pathway:WP534" class="plainlinks" shape="rect" coords="103,148,254,167" alt="Go to WikiPathways" title="Go to WikiPathways" /><area href="/wiki/Fumarase" shape="rect" coords="202,428,234,448" alt="Go to article" title="Go to article" /><area href="/wiki/Fumaric_acid" shape="rect" coords="237,478,299,498" alt="Go to HMDB" title="Go to HMDB" /><area href="/wiki/Malate_dehydrogenase_2" shape="rect" coords="213,315,261,335" alt="Go to article" title="Go to article" /><area href="/wiki/Succinyl-CoA" shape="rect" coords="514,677,594,700" alt="Go to article" title="Go to article" /><area href="/wiki/Carbon_dioxide" shape="rect" coords="658,512,689,526" alt="Go to article" title="Go to article" /><area href="/wiki/Carbon_dioxide" shape="rect" coords="605,701,632,716" alt="Go to article" title="Go to article" /><area href="/wiki/Phosphate" shape="rect" coords="457,712,477,726" alt="Go to article" title="Go to article" /><area href="/wiki/Water" shape="rect" coords="769,313,811,328" alt="Go to article" title="Go to article" /><area href="/wiki/Coenzyme_A" shape="rect" coords="403,548,433,563" alt="Go to article" title="Go to article" /><area href="/wiki/Phosphate" shape="rect" coords="520,588,540,602" alt="Go to article" title="Go to article" /><area href="/wiki/SUCLA2" shape="rect" coords="455,537,515,557" alt="Go to article" title="Go to article" /><area href="/wiki/SUCLG1" shape="rect" coords="455,517,515,537" alt="Go to article" title="Go to article" /></map><figcaption></figcaption></figure></div> </div> <div class="thumbcaption"></div> </div></div>|alt=TCACycle_WP78 <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP78">edit</a>]]</div></div> </div> <div class="thumbcaption"> <div class="magnify"><a href="/wiki/File:TCACycle_WP78.png" title="File:TCACycle WP78.png"> </a></div>TCACycle_WP78 <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP78">edit</a> </div> </div> </div> <div style="clear:both;" class=""></div><style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-WikiPathways-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-WikiPathways_16-0">^</a></b></span> <span class="reference-text">The interactive pathway map can be edited at WikiPathways: <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP78">"TCACycle_WP78"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=TCACycle_WP78&rft_id=http%3A%2F%2Fwww.wikipathways.org%2Findex.php%2FPathway%3AWP78&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> </ol></div></div> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=5" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/IDH1" class="mw-redirect" title="IDH1">IDH1</a></li> <li><a href="/wiki/IDH2" title="IDH2">IDH2</a></li> <li><a href="/wiki/IDH3A" title="IDH3A">IDH3A</a></li> <li><a href="/wiki/IDH3B" title="IDH3B">IDH3B</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626" /><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000067829">GRCh38: Ensembl release 89: ENSG00000067829</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000002010">GRCm38: Ensembl release 89: ENSMUSG00000002010</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=3421">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D3421&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=15929">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D15929&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid9286695-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9286695_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBrennerNyakaturaRosenthalPlatzer1997" class="citation journal cs1">Brenner V, Nyakatura G, Rosenthal A, Platzer M (August 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". <i>Genomics</i>. <b>44</b> (1): <span class="nowrap">8–</span>14. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1997.4822">10.1006/geno.1997.4822</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9286695">9286695</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Genomic+organization+of+two+novel+genes+on+human+Xq28%3A+compact+head+to+head+arrangement+of+IDH+gamma+and+TRAP+delta+is+conserved+in+rat+and+mouse&rft.volume=44&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8-%3C%2Fspan%3E14&rft.date=1997-08&rft_id=info%3Adoi%2F10.1006%2Fgeno.1997.4822&rft_id=info%3Apmid%2F9286695&rft.aulast=Brenner&rft.aufirst=V&rft.au=Nyakatura%2C+G&rft.au=Rosenthal%2C+A&rft.au=Platzer%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-entrez-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_6-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3421">"Entrez Gene: IDH3G isocitrate dehydrogenase 3 (NAD+) gamma"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+IDH3G+isocitrate+dehydrogenase+3+%28NAD%2B%29+gamma&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D3421&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid25678837-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid25678837_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDimitrovHongYangZhuang2015" class="citation journal cs1">Dimitrov L, Hong CS, Yang C, Zhuang Z, Heiss JD (2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323358">"New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma"</a>. <i>International Journal of Medical Sciences</i>. <b>12</b> (3): <span class="nowrap">201–</span>213. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.7150%2Fijms.11047">10.7150/ijms.11047</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323358">4323358</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25678837">25678837</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Medical+Sciences&rft.atitle=New+developments+in+the+pathogenesis+and+therapeutic+targeting+of+the+IDH1+mutation+in+glioma&rft.volume=12&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E201-%3C%2Fspan%3E213&rft.date=2015&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4323358%23id-name%3DPMC&rft_id=info%3Apmid%2F25678837&rft_id=info%3Adoi%2F10.7150%2Fijms.11047&rft.aulast=Dimitrov&rft.aufirst=L&rft.au=Hong%2C+CS&rft.au=Yang%2C+C&rft.au=Zhuang%2C+Z&rft.au=Heiss%2C+JD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4323358&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid25531325-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid25531325_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid25531325_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid25531325_8-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZengMorinibuKobayashiZhu2015" class="citation journal cs1">Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, et al. (September 2015). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fonc.2014.411">"Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis"</a>. <i>Oncogene</i>. <b>34</b> (36): <span class="nowrap">4758–</span>4766. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fonc.2014.411">10.1038/onc.2014.411</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25531325">25531325</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Aberrant+IDH3%CE%B1+expression+promotes+malignant+tumor+growth+by+inducing+HIF-1-mediated+metabolic+reprogramming+and+angiogenesis&rft.volume=34&rft.issue=36&rft.pages=%3Cspan+class%3D%22nowrap%22%3E4758-%3C%2Fspan%3E4766&rft.date=2015-09&rft_id=info%3Adoi%2F10.1038%2Fonc.2014.411&rft_id=info%3Apmid%2F25531325&rft.aulast=Zeng&rft.aufirst=L&rft.au=Morinibu%2C+A&rft.au=Kobayashi%2C+M&rft.au=Zhu%2C+Y&rft.au=Wang%2C+X&rft.au=Goto%2C+Y&rft.au=Yeom%2C+CJ&rft.au=Zhao%2C+T&rft.au=Hirota%2C+K&rft.au=Shinomiya%2C+K&rft.au=Itasaka%2C+S&rft.au=Yoshimura%2C+M&rft.au=Guo%2C+G&rft.au=Hammond%2C+EM&rft.au=Hiraoka%2C+M&rft.au=Harada%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fonc.2014.411&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid17432878-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid17432878_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-pmid17432878_9-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBzymekColman2007" class="citation journal cs1">Bzymek KP, Colman RF (May 2007). "Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase". <i>Biochemistry</i>. <b>46</b> (18): <span class="nowrap">5391–</span>5397. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fbi700061t">10.1021/bi700061t</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17432878">17432878</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Role+of+alpha-Asp181%2C+beta-Asp192%2C+and+gamma-Asp190+in+the+distinctive+subunits+of+human+NAD-specific+isocitrate+dehydrogenase&rft.volume=46&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5391-%3C%2Fspan%3E5397&rft.date=2007-05&rft_id=info%3Adoi%2F10.1021%2Fbi700061t&rft_id=info%3Apmid%2F17432878&rft.aulast=Bzymek&rft.aufirst=KP&rft.au=Colman%2C+RF&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid16737955-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid16737955_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid16737955_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid16737955_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid16737955_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid16737955_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid16737955_10-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid16737955_10-6"><sup><i><b>g</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSoundarO'HaganFomuluColman2006" class="citation journal cs1">Soundar S, O'Hagan M, Fomulu KS, Colman RF (July 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.m602956200">"Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase"</a>. <i>The Journal of Biological Chemistry</i>. <b>281</b> (30): <span class="nowrap">21073–</span>21081. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.m602956200">10.1074/jbc.m602956200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16737955">16737955</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Identification+of+Mn2%2B-binding+aspartates+from+alpha%2C+beta%2C+and+gamma+subunits+of+human+NAD-dependent+isocitrate+dehydrogenase&rft.volume=281&rft.issue=30&rft.pages=%3Cspan+class%3D%22nowrap%22%3E21073-%3C%2Fspan%3E21081&rft.date=2006-07&rft_id=info%3Adoi%2F10.1074%2Fjbc.m602956200&rft_id=info%3Apmid%2F16737955&rft.aulast=Soundar&rft.aufirst=S&rft.au=O%27Hagan%2C+M&rft.au=Fomulu%2C+KS&rft.au=Colman%2C+RF&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.m602956200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid14555658-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid14555658_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid14555658_11-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid14555658_11-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid14555658_11-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid14555658_11-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSoundarParkHuhColman2003" class="citation journal cs1">Soundar S, Park JH, Huh TL, Colman RF (December 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.m306178200">"Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase"</a>. <i>The Journal of Biological Chemistry</i>. <b>278</b> (52): <span class="nowrap">52146–</span>52153. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.m306178200">10.1074/jbc.m306178200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14555658">14555658</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Evaluation+by+mutagenesis+of+the+importance+of+3+arginines+in+alpha%2C+beta%2C+and+gamma+subunits+of+human+NAD-dependent+isocitrate+dehydrogenase&rft.volume=278&rft.issue=52&rft.pages=%3Cspan+class%3D%22nowrap%22%3E52146-%3C%2Fspan%3E52153&rft.date=2003-12&rft_id=info%3Adoi%2F10.1074%2Fjbc.m306178200&rft_id=info%3Apmid%2F14555658&rft.aulast=Soundar&rft.aufirst=S&rft.au=Park%2C+JH&rft.au=Huh%2C+TL&rft.au=Colman%2C+RF&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.m306178200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid20435888-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20435888_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDangeColman2010" class="citation journal cs1">Dange M, Colman RF (July 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898308">"Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function"</a>. <i>The Journal of Biological Chemistry</i>. <b>285</b> (27): <span class="nowrap">20520–</span>20525. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.m110.115386">10.1074/jbc.m110.115386</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898308">2898308</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20435888">20435888</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Each+conserved+active+site+tyr+in+the+three+subunits+of+human+isocitrate+dehydrogenase+has+a+different+function&rft.volume=285&rft.issue=27&rft.pages=%3Cspan+class%3D%22nowrap%22%3E20520-%3C%2Fspan%3E20525&rft.date=2010-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2898308%23id-name%3DPMC&rft_id=info%3Apmid%2F20435888&rft_id=info%3Adoi%2F10.1074%2Fjbc.m110.115386&rft.aulast=Dange&rft.aufirst=M&rft.au=Colman%2C+RF&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2898308&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid8833160-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid8833160_13-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid8833160_13-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid8833160_13-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHuhKimOhSong1996" class="citation journal cs1">Huh TL, Kim YO, Oh IU, Song BJ, Inazawa J (March 1996). "Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization". <i>Genomics</i>. <b>32</b> (2): <span class="nowrap">295–</span>296. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1996.0120">10.1006/geno.1996.0120</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8833160">8833160</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Assignment+of+the+human+mitochondrial+NAD%2B+-specific+isocitrate+dehydrogenase+alpha+subunit+%28IDH3A%29+gene+to+15q25.1--%3Eq25.2by+in+situ+hybridization&rft.volume=32&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E295-%3C%2Fspan%3E296&rft.date=1996-03&rft_id=info%3Adoi%2F10.1006%2Fgeno.1996.0120&rft_id=info%3Apmid%2F8833160&rft.aulast=Huh&rft.aufirst=TL&rft.au=Kim%2C+YO&rft.au=Oh%2C+IU&rft.au=Song%2C+BJ&rft.au=Inazawa%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-pmid26782057-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid26782057_14-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFYoshimiFutamuraBergenIwayama2016" class="citation journal cs1">Yoshimi N, Futamura T, Bergen SE, Iwayama Y, Ishima T, Sellgren C, et al. (November 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078854">"Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis"</a>. <i>Molecular Psychiatry</i>. <b>21</b> (11): <span class="nowrap">1504–</span>1510. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmp.2015.217">10.1038/mp.2015.217</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078854">5078854</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26782057">26782057</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Psychiatry&rft.atitle=Cerebrospinal+fluid+metabolomics+identifies+a+key+role+of+isocitrate+dehydrogenase+in+bipolar+disorder%3A+evidence+in+support+of+mitochondrial+dysfunction+hypothesis&rft.volume=21&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1504-%3C%2Fspan%3E1510&rft.date=2016-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5078854%23id-name%3DPMC&rft_id=info%3Apmid%2F26782057&rft_id=info%3Adoi%2F10.1038%2Fmp.2015.217&rft.aulast=Yoshimi&rft.aufirst=N&rft.au=Futamura%2C+T&rft.au=Bergen%2C+SE&rft.au=Iwayama%2C+Y&rft.au=Ishima%2C+T&rft.au=Sellgren%2C+C&rft.au=Ekman%2C+CJ&rft.au=Jakobsson%2C+J&rft.au=P%C3%A5lsson%2C+E&rft.au=Kakumoto%2C+K&rft.au=Ohgi%2C+Y&rft.au=Yoshikawa%2C+T&rft.au=Land%C3%A9n%2C+M&rft.au=Hashimoto%2C+K&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5078854&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZhouYongYapVijayaraghavan2015" class="citation journal cs1">Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, et al. (April 2015). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fcarcin%2Fbgv014">"An integrative approach identified genes associated with drug response in gastric cancer"</a>. <i>Carcinogenesis</i>. <b>36</b> (4): <span class="nowrap">441–</span>451. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fcarcin%2Fbgv014">10.1093/carcin/bgv014</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25742747">25742747</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=An+integrative+approach+identified+genes+associated+with+drug+response+in+gastric+cancer&rft.volume=36&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E441-%3C%2Fspan%3E451&rft.date=2015-04&rft_id=info%3Adoi%2F10.1093%2Fcarcin%2Fbgv014&rft_id=info%3Apmid%2F25742747&rft.aulast=Zhou&rft.aufirst=J&rft.au=Yong%2C+WP&rft.au=Yap%2C+CS&rft.au=Vijayaraghavan%2C+A&rft.au=Sinha%2C+RA&rft.au=Singh%2C+BK&rft.au=Xiu%2C+S&rft.au=Manesh%2C+S&rft.au=Ngo%2C+A&rft.au=Lim%2C+A&rft.au=Ang%2C+C&rft.au=Xie%2C+C&rft.au=Wong%2C+FY&rft.au=Lin%2C+SJ&rft.au=Wan%2C+WK&rft.au=Tan%2C+IB&rft.au=Flotow%2C+H&rft.au=Tan%2C+P&rft.au=Lim%2C+KH&rft.au=Yen%2C+PM&rft.au=Goh%2C+LK&rft_id=https%3A%2F%2Fdoi.org%2F10.1093%252Fcarcin%252Fbgv014&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=IDH3G&action=edit&section=7" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSandovalBauerBrennerCoy1996" class="citation journal cs1">Sandoval N, Bauer D, Brenner V, Coy JF, Drescher B, Kioschis P, et al. (July 1996). "The genomic organization of a human creatine transporter (CRTR) gene located in Xq28". <i>Genomics</i>. <b>35</b> (2): <span class="nowrap">383–</span>385. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fgeno.1996.0373">10.1006/geno.1996.0373</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8661155">8661155</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=The+genomic+organization+of+a+human+creatine+transporter+%28CRTR%29+gene+located+in+Xq28&rft.volume=35&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E383-%3C%2Fspan%3E385&rft.date=1996-07&rft_id=info%3Adoi%2F10.1006%2Fgeno.1996.0373&rft_id=info%3Apmid%2F8661155&rft.aulast=Sandoval&rft.aufirst=N&rft.au=Bauer%2C+D&rft.au=Brenner%2C+V&rft.au=Coy%2C+JF&rft.au=Drescher%2C+B&rft.au=Kioschis%2C+P&rft.au=Korn%2C+B&rft.au=Nyakatura%2C+G&rft.au=Poustka%2C+A&rft.au=Reichwald%2C+K&rft.au=Rosenthal%2C+A&rft.au=Platzer%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKimKohKimJo1999" class="citation journal cs1">Kim YO, Koh HJ, Kim SH, Jo SH, Huh JW, Jeong KS, et al. (December 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.52.36866">"Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform"</a>. <i>The Journal of Biological Chemistry</i>. <b>274</b> (52): <span class="nowrap">36866–</span>36875. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.52.36866">10.1074/jbc.274.52.36866</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10601238">10601238</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Identification+and+functional+characterization+of+a+novel%2C+tissue-specific+NAD%28%2B%29-dependent+isocitrate+dehydrogenase+beta+subunit+isoform&rft.volume=274&rft.issue=52&rft.pages=%3Cspan+class%3D%22nowrap%22%3E36866-%3C%2Fspan%3E36875&rft.date=1999-12&rft_id=info%3Adoi%2F10.1074%2Fjbc.274.52.36866&rft_id=info%3Apmid%2F10601238&rft.aulast=Kim&rft.aufirst=YO&rft.au=Koh%2C+HJ&rft.au=Kim%2C+SH&rft.au=Jo%2C+SH&rft.au=Huh%2C+JW&rft.au=Jeong%2C+KS&rft.au=Lee%2C+IJ&rft.au=Song%2C+BJ&rft.au=Huh%2C+TL&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.274.52.36866&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWeissZengHuangSobocka2000" class="citation journal cs1">Weiss C, Zeng Y, Huang J, Sobocka MB, Rushbrook JI (February 2000). "Bovine NAD+-dependent isocitrate dehydrogenase: alternative splicing and tissue-dependent expression of subunit 1". <i>Biochemistry</i>. <b>39</b> (7): <span class="nowrap">1807–</span>1816. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fbi991691i">10.1021/bi991691i</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10677231">10677231</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Bovine+NAD%2B-dependent+isocitrate+dehydrogenase%3A+alternative+splicing+and+tissue-dependent+expression+of+subunit+1&rft.volume=39&rft.issue=7&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1807-%3C%2Fspan%3E1816&rft.date=2000-02&rft_id=info%3Adoi%2F10.1021%2Fbi991691i&rft_id=info%3Apmid%2F10677231&rft.aulast=Weiss&rft.aufirst=C&rft.au=Zeng%2C+Y&rft.au=Huang%2C+J&rft.au=Sobocka%2C+MB&rft.au=Rushbrook%2C+JI&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHartleyTempleBrasch2000" class="citation journal cs1">Hartley JL, Temple GF, Brasch MA (November 2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948">"DNA cloning using in vitro site-specific recombination"</a>. <i>Genome Research</i>. <b>10</b> (11): <span class="nowrap">1788–</span>1795. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.143000">10.1101/gr.143000</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948">310948</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11076863">11076863</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=DNA+cloning+using+in+vitro+site-specific+recombination&rft.volume=10&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1788-%3C%2Fspan%3E1795&rft.date=2000-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC310948%23id-name%3DPMC&rft_id=info%3Apmid%2F11076863&rft_id=info%3Adoi%2F10.1101%2Fgr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple%2C+GF&rft.au=Brasch%2C+MA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC310948&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSimpsonWellenreutherPoustkaPepperkok2000" class="citation journal cs1">Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732">"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"</a>. <i>EMBO Reports</i>. <b>1</b> (3): <span class="nowrap">287–</span>292. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fembo-reports%2Fkvd058">10.1093/embo-reports/kvd058</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732">1083732</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11256614">11256614</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=EMBO+Reports&rft.atitle=Systematic+subcellular+localization+of+novel+proteins+identified+by+large-scale+cDNA+sequencing&rft.volume=1&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E287-%3C%2Fspan%3E292&rft.date=2000-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1083732%23id-name%3DPMC&rft_id=info%3Apmid%2F11256614&rft_id=info%3Adoi%2F10.1093%2Fembo-reports%2Fkvd058&rft.aulast=Simpson&rft.aufirst=JC&rft.au=Wellenreuther%2C+R&rft.au=Poustka%2C+A&rft.au=Pepperkok%2C+R&rft.au=Wiemann%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1083732&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFStrausbergFeingoldGrouseDerge2002" class="citation journal cs1">Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>99</b> (26): <span class="nowrap">16899–</span>16903. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Generation+and+initial+analysis+of+more+than+15%2C000+full-length+human+and+mouse+cDNA+sequences&rft.volume=99&rft.issue=26&rft.pages=%3Cspan+class%3D%22nowrap%22%3E16899-%3C%2Fspan%3E16903&rft.date=2002-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC139241%23id-name%3DPMC&rft_id=info%3Apmid%2F12477932&rft_id=info%3Adoi%2F10.1073%2Fpnas.242603899&rft_id=info%3Abibcode%2F2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold%2C+EA&rft.au=Grouse%2C+LH&rft.au=Derge%2C+JG&rft.au=Klausner%2C+RD&rft.au=Collins%2C+FS&rft.au=Wagner%2C+L&rft.au=Shenmen%2C+CM&rft.au=Schuler%2C+GD&rft.au=Altschul%2C+SF&rft.au=Zeeberg%2C+B&rft.au=Buetow%2C+KH&rft.au=Schaefer%2C+CF&rft.au=Bhat%2C+NK&rft.au=Hopkins%2C+RF&rft.au=Jordan%2C+H&rft.au=Moore%2C+T&rft.au=Max%2C+SI&rft.au=Wang%2C+J&rft.au=Hsieh%2C+F&rft.au=Diatchenko%2C+L&rft.au=Marusina%2C+K&rft.au=Farmer%2C+AA&rft.au=Rubin%2C+GM&rft.au=Hong%2C+L&rft.au=Stapleton%2C+M&rft.au=Soares%2C+MB&rft.au=Bonaldo%2C+MF&rft.au=Casavant%2C+TL&rft.au=Scheetz%2C+TE&rft.au=Brownstein%2C+MJ&rft.au=Usdin%2C+TB&rft.au=Toshiyuki%2C+S&rft.au=Carninci%2C+P&rft.au=Prange%2C+C&rft.au=Raha%2C+SS&rft.au=Loquellano%2C+NA&rft.au=Peters%2C+GJ&rft.au=Abramson%2C+RD&rft.au=Mullahy%2C+SJ&rft.au=Bosak%2C+SA&rft.au=McEwan%2C+PJ&rft.au=McKernan%2C+KJ&rft.au=Malek%2C+JA&rft.au=Gunaratne%2C+PH&rft.au=Richards%2C+S&rft.au=Worley%2C+KC&rft.au=Hale%2C+S&rft.au=Garcia%2C+AM&rft.au=Gay%2C+LJ&rft.au=Hulyk%2C+SW&rft.au=Villalon%2C+DK&rft.au=Muzny%2C+DM&rft.au=Sodergren%2C+EJ&rft.au=Lu%2C+X&rft.au=Gibbs%2C+RA&rft.au=Fahey%2C+J&rft.au=Helton%2C+E&rft.au=Ketteman%2C+M&rft.au=Madan%2C+A&rft.au=Rodrigues%2C+S&rft.au=Sanchez%2C+A&rft.au=Whiting%2C+M&rft.au=Madan%2C+A&rft.au=Young%2C+AC&rft.au=Shevchenko%2C+Y&rft.au=Bouffard%2C+GG&rft.au=Blakesley%2C+RW&rft.au=Touchman%2C+JW&rft.au=Green%2C+ED&rft.au=Dickson%2C+MC&rft.au=Rodriguez%2C+AC&rft.au=Grimwood%2C+J&rft.au=Schmutz%2C+J&rft.au=Myers%2C+RM&rft.au=Butterfield%2C+YS&rft.au=Krzywinski%2C+MI&rft.au=Skalska%2C+U&rft.au=Smailus%2C+DE&rft.au=Schnerch%2C+A&rft.au=Schein%2C+JE&rft.au=Jones%2C+SJ&rft.au=Marra%2C+MA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC139241&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGerhardWagnerFeingoldShenmen2004" class="citation journal cs1">Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"</a>. <i>Genome Research</i>. <b>14</b> (10B): <span class="nowrap">2121–</span>2127. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.2596504">10.1101/gr.2596504</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">528928</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15489334">15489334</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=The+status%2C+quality%2C+and+expansion+of+the+NIH+full-length+cDNA+project%3A+the+Mammalian+Gene+Collection+%28MGC%29&rft.volume=14&rft.issue=10B&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2121-%3C%2Fspan%3E2127&rft.date=2004-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC528928%23id-name%3DPMC&rft_id=info%3Apmid%2F15489334&rft_id=info%3Adoi%2F10.1101%2Fgr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner%2C+L&rft.au=Feingold%2C+EA&rft.au=Shenmen%2C+CM&rft.au=Grouse%2C+LH&rft.au=Schuler%2C+G&rft.au=Klein%2C+SL&rft.au=Old%2C+S&rft.au=Rasooly%2C+R&rft.au=Good%2C+P&rft.au=Guyer%2C+M&rft.au=Peck%2C+AM&rft.au=Derge%2C+JG&rft.au=Lipman%2C+D&rft.au=Collins%2C+FS&rft.au=Jang%2C+W&rft.au=Sherry%2C+S&rft.au=Feolo%2C+M&rft.au=Misquitta%2C+L&rft.au=Lee%2C+E&rft.au=Rotmistrovsky%2C+K&rft.au=Greenhut%2C+SF&rft.au=Schaefer%2C+CF&rft.au=Buetow%2C+K&rft.au=Bonner%2C+TI&rft.au=Haussler%2C+D&rft.au=Kent%2C+J&rft.au=Kiekhaus%2C+M&rft.au=Furey%2C+T&rft.au=Brent%2C+M&rft.au=Prange%2C+C&rft.au=Schreiber%2C+K&rft.au=Shapiro%2C+N&rft.au=Bhat%2C+NK&rft.au=Hopkins%2C+RF&rft.au=Hsie%2C+F&rft.au=Driscoll%2C+T&rft.au=Soares%2C+MB&rft.au=Casavant%2C+TL&rft.au=Scheetz%2C+TE&rft.au=Brown-stein%2C+MJ&rft.au=Usdin%2C+TB&rft.au=Toshiyuki%2C+S&rft.au=Carninci%2C+P&rft.au=Piao%2C+Y&rft.au=Dudekula%2C+DB&rft.au=Ko%2C+MS&rft.au=Kawakami%2C+K&rft.au=Suzuki%2C+Y&rft.au=Sugano%2C+S&rft.au=Gruber%2C+CE&rft.au=Smith%2C+MR&rft.au=Simmons%2C+B&rft.au=Moore%2C+T&rft.au=Waterman%2C+R&rft.au=Johnson%2C+SL&rft.au=Ruan%2C+Y&rft.au=Wei%2C+CL&rft.au=Mathavan%2C+S&rft.au=Gunaratne%2C+PH&rft.au=Wu%2C+J&rft.au=Garcia%2C+AM&rft.au=Hulyk%2C+SW&rft.au=Fuh%2C+E&rft.au=Yuan%2C+Y&rft.au=Sneed%2C+A&rft.au=Kowis%2C+C&rft.au=Hodgson%2C+A&rft.au=Muzny%2C+DM&rft.au=McPherson%2C+J&rft.au=Gibbs%2C+RA&rft.au=Fahey%2C+J&rft.au=Helton%2C+E&rft.au=Ketteman%2C+M&rft.au=Madan%2C+A&rft.au=Rodrigues%2C+S&rft.au=Sanchez%2C+A&rft.au=Whiting%2C+M&rft.au=Madari%2C+A&rft.au=Young%2C+AC&rft.au=Wetherby%2C+KD&rft.au=Granite%2C+SJ&rft.au=Kwong%2C+PN&rft.au=Brinkley%2C+CP&rft.au=Pearson%2C+RL&rft.au=Bouffard%2C+GG&rft.au=Blakesly%2C+RW&rft.au=Green%2C+ED&rft.au=Dickson%2C+MC&rft.au=Rodriguez%2C+AC&rft.au=Grimwood%2C+J&rft.au=Schmutz%2C+J&rft.au=Myers%2C+RM&rft.au=Butterfield%2C+YS&rft.au=Griffith%2C+M&rft.au=Griffith%2C+OL&rft.au=Krzywinski%2C+MI&rft.au=Liao%2C+N&rft.au=Morin%2C+R&rft.au=Palmquist%2C+D&rft.au=Petrescu%2C+AS&rft.au=Skalska%2C+U&rft.au=Smailus%2C+DE&rft.au=Stott%2C+JM&rft.au=Schnerch%2C+A&rft.au=Schein%2C+JE&rft.au=Jones%2C+SJ&rft.au=Holt%2C+RA&rft.au=Baross%2C+A&rft.au=Marra%2C+MA&rft.au=Clifton%2C+S&rft.au=Makowski%2C+KA&rft.au=Bosak%2C+S&rft.au=Malek%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC528928&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWiemannArltHuberWellenreuther2004" class="citation journal cs1">Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930">"From ORFeome to biology: a functional genomics pipeline"</a>. <i>Genome Research</i>. <b>14</b> (10B): <span class="nowrap">2136–</span>2144. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.2576704">10.1101/gr.2576704</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930">528930</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15489336">15489336</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=From+ORFeome+to+biology%3A+a+functional+genomics+pipeline&rft.volume=14&rft.issue=10B&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2136-%3C%2Fspan%3E2144&rft.date=2004-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC528930%23id-name%3DPMC&rft_id=info%3Apmid%2F15489336&rft_id=info%3Adoi%2F10.1101%2Fgr.2576704&rft.aulast=Wiemann&rft.aufirst=S&rft.au=Arlt%2C+D&rft.au=Huber%2C+W&rft.au=Wellenreuther%2C+R&rft.au=Schleeger%2C+S&rft.au=Mehrle%2C+A&rft.au=Bechtel%2C+S&rft.au=Sauermann%2C+M&rft.au=Korf%2C+U&rft.au=Pepperkok%2C+R&rft.au=S%C3%BCltmann%2C+H&rft.au=Poustka%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC528930&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRualVenkatesanHaoHirozane-Kishikawa2005" class="citation journal cs1">Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". <i>Nature</i>. <b>437</b> (7062): <span class="nowrap">1173–</span>1178. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R">2005Natur.437.1173R</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature04209">10.1038/nature04209</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16189514">16189514</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4427026">4427026</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Towards+a+proteome-scale+map+of+the+human+protein-protein+interaction+network&rft.volume=437&rft.issue=7062&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1173-%3C%2Fspan%3E1178&rft.date=2005-10&rft_id=info%3Adoi%2F10.1038%2Fnature04209&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4427026%23id-name%3DS2CID&rft_id=info%3Apmid%2F16189514&rft_id=info%3Abibcode%2F2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan%2C+K&rft.au=Hao%2C+T&rft.au=Hirozane-Kishikawa%2C+T&rft.au=Dricot%2C+A&rft.au=Li%2C+N&rft.au=Berriz%2C+GF&rft.au=Gibbons%2C+FD&rft.au=Dreze%2C+M&rft.au=Ayivi-Guedehoussou%2C+N&rft.au=Klitgord%2C+N&rft.au=Simon%2C+C&rft.au=Boxem%2C+M&rft.au=Milstein%2C+S&rft.au=Rosenberg%2C+J&rft.au=Goldberg%2C+DS&rft.au=Zhang%2C+LV&rft.au=Wong%2C+SL&rft.au=Franklin%2C+G&rft.au=Li%2C+S&rft.au=Albala%2C+JS&rft.au=Lim%2C+J&rft.au=Fraughton%2C+C&rft.au=Llamosas%2C+E&rft.au=Cevik%2C+S&rft.au=Bex%2C+C&rft.au=Lamesch%2C+P&rft.au=Sikorski%2C+RS&rft.au=Vandenhaute%2C+J&rft.au=Zoghbi%2C+HY&rft.au=Smolyar%2C+A&rft.au=Bosak%2C+S&rft.au=Sequerra%2C+R&rft.au=Doucette-Stamm%2C+L&rft.au=Cusick%2C+ME&rft.au=Hill%2C+DE&rft.au=Roth%2C+FP&rft.au=Vidal%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMehrleRosenfelderSchuppdel_Val2006" class="citation journal cs1">Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501">"The LIFEdb database in 2006"</a>. <i>Nucleic Acids Research</i>. <b>34</b> (Database issue): <span class="nowrap">D415 –</span> <span class="nowrap">D418</span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgkj139">10.1093/nar/gkj139</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347501">1347501</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16381901">16381901</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+LIFEdb+database+in+2006&rft.volume=34&rft.issue=Database+issue&rft.pages=%3Cspan+class%3D%22nowrap%22%3ED415+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3ED418%3C%2Fspan%3E&rft.date=2006-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1347501%23id-name%3DPMC&rft_id=info%3Apmid%2F16381901&rft_id=info%3Adoi%2F10.1093%2Fnar%2Fgkj139&rft.aulast=Mehrle&rft.aufirst=A&rft.au=Rosenfelder%2C+H&rft.au=Schupp%2C+I&rft.au=del+Val%2C+C&rft.au=Arlt%2C+D&rft.au=Hahne%2C+F&rft.au=Bechtel%2C+S&rft.au=Simpson%2C+J&rft.au=Hofmann%2C+O&rft.au=Hide%2C+W&rft.au=Glatting%2C+KH&rft.au=Huber%2C+W&rft.au=Pepperkok%2C+R&rft.au=Poustka%2C+A&rft.au=Wiemann%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1347501&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSoundarO'HaganFomuluColman2006" class="citation journal cs1">Soundar S, O'Hagan M, Fomulu KS, Colman RF (July 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M602956200">"Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase"</a>. <i>The Journal of Biological Chemistry</i>. <b>281</b> (30): <span class="nowrap">21073–</span>21081. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M602956200">10.1074/jbc.M602956200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16737955">16737955</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Identification+of+Mn2%2B-binding+aspartates+from+alpha%2C+beta%2C+and+gamma+subunits+of+human+NAD-dependent+isocitrate+dehydrogenase&rft.volume=281&rft.issue=30&rft.pages=%3Cspan+class%3D%22nowrap%22%3E21073-%3C%2Fspan%3E21081&rft.date=2006-07&rft_id=info%3Adoi%2F10.1074%2Fjbc.M602956200&rft_id=info%3Apmid%2F16737955&rft.aulast=Soundar&rft.aufirst=S&rft.au=O%27Hagan%2C+M&rft.au=Fomulu%2C+KS&rft.au=Colman%2C+RF&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M602956200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AIDH3G" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBzymekColman2007" class="citation journal cs1">Bzymek KP, Colman RF (May 2007). "Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase". <i>Biochemistry</i>. <b>46</b> (18): <span class="nowrap">5391–</span>5397. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fbi700061t">10.1021/bi700061t</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17432878">17432878</a>.</cite><span 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title="Template:Serine/threonine-specific protein kinases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Serine/threonine-specific_protein_kinases" title="Template talk:Serine/threonine-specific protein kinases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Serine/threonine-specific_protein_kinases" title="Special:EditPage/Template:Serine/threonine-specific protein kinases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Kinases:_Serine/threonine-specific_protein_kinases_(EC_2.7.11-12)102" style="font-size:114%;margin:0 4em"><a href="/wiki/Kinase" title="Kinase">Kinases</a>: <a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">Serine/threonine-specific protein kinases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.7.11-12)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Serine/threonine-specific_protein_kinases_(EC_2.7.11.1-EC_2.7.11.20)102" style="font-size:114%;margin:0 4em"><a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">Serine/threonine-specific protein kinases</a> (EC 2.7.11.1-EC 2.7.11.20)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Non-specific_serine/threonine_protein_kinase" class="mw-redirect" title="Non-specific serine/threonine protein kinase">Non-specific serine/threonine protein kinases</a> (EC 2.7.11.1)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/LATS1" title="LATS1">LATS1</a></li> <li><a href="/wiki/LATS2" title="LATS2">LATS2</a></li> <li><a href="/wiki/MAST1" title="MAST1">MAST1</a></li> <li><a href="/wiki/MAST2" title="MAST2">MAST2</a></li> <li><a href="/wiki/STK38" title="STK38">STK38</a></li> <li><a href="/wiki/STK38L" title="STK38L">STK38L</a></li> <li><a href="/wiki/CIT_(gene)" class="mw-redirect" title="CIT (gene)">CIT</a></li> <li><a href="/wiki/ROCK1" title="ROCK1">ROCK1</a></li> <li><a href="/wiki/SGK" title="SGK">SGK</a></li> <li><a href="/wiki/SGK2" title="SGK2">SGK2</a></li> <li><a href="/wiki/SGK3" title="SGK3">SGK3</a></li> <li><a href="/wiki/AKT" class="mw-redirect" title="AKT">Protein kinase B</a> <ul><li><a href="/wiki/AKT1" title="AKT1">AKT1</a></li> <li><a href="/wiki/AKT2" title="AKT2">AKT2</a></li> <li><a href="/wiki/AKT3" title="AKT3">AKT3</a></li></ul></li> <li><a href="/wiki/Ataxia_telangiectasia_mutated" class="mw-redirect" title="Ataxia telangiectasia mutated">Ataxia telangiectasia mutated</a></li> <li><a href="/wiki/MTOR" title="MTOR">mTOR</a></li> <li><a href="/wiki/EIF-2_kinase" title="EIF-2 kinase">EIF-2 kinases</a> <ul><li><a href="/wiki/Protein_kinase_R" title="Protein kinase R">PKR</a></li> <li><a href="/wiki/EIF2AK1" title="EIF2AK1">HRI</a></li> <li><a href="/wiki/EIF2AK3" title="EIF2AK3">EIF2AK3</a></li> <li><a href="/wiki/EIF2AK4" title="EIF2AK4">EIF2AK4</a></li></ul></li> <li><a href="/wiki/Wee1" title="Wee1">Wee1</a> <ul><li><a href="/wiki/Wee1-like_protein_kinase" title="Wee1-like protein kinase">WEE1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pyruvate_dehydrogenase_kinase" title="Pyruvate dehydrogenase kinase">Pyruvate dehydrogenase kinase</a> (EC 2.7.11.2)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pyruvate_dehydrogenase_lipoamide_kinase_isozyme_1" title="Pyruvate dehydrogenase lipoamide kinase isozyme 1">PDK1</a></li> <li><a href="/wiki/PDK2" title="PDK2">PDK2</a></li> <li><a href="/wiki/PDK3" title="PDK3">PDK3</a></li> <li><a href="/wiki/PDK4" title="PDK4">PDK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dephospho-(reductase_kinase)_kinase" title="Dephospho-(reductase kinase) kinase">Dephospho-(reductase kinase) kinase</a> (EC 2.7.11.3)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AMP-activated_protein_kinase" title="AMP-activated protein kinase">AMP-activated protein kinase</a> α <ul><li><a href="/wiki/Protein_kinase,_AMP-activated,_alpha_1" title="Protein kinase, AMP-activated, alpha 1">PRKAA1</a></li> <li><a href="/wiki/PRKAA2" title="PRKAA2">PRKAA2</a></li></ul></li> <li>β <ul><li><a href="/wiki/PRKAB1" title="PRKAB1">PRKAB1</a></li> <li><a href="/wiki/PRKAB2" title="PRKAB2">PRKAB2</a></li></ul></li> <li>γ <ul><li><a href="/wiki/PRKAG1" title="PRKAG1">PRKAG1</a></li> <li><a href="/wiki/PRKAG2" title="PRKAG2">PRKAG2</a></li> <li><a href="/wiki/PRKAG3" title="PRKAG3">PRKAG3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)_kinase" title="3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase">3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase</a> (EC 2.7.11.4)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BCKDK" title="BCKDK">BCKDK</a></li> <li><a href="/wiki/BCKDHA" title="BCKDHA">BCKDHA</a></li> <li><a href="/wiki/BCKDHB" title="BCKDHB">BCKDHB</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(isocitrate_dehydrogenase_(NADP%2B))_kinase" class="mw-redirect" title="(isocitrate dehydrogenase (NADP+)) kinase">(isocitrate dehydrogenase (NADP+)) kinase</a> (EC 2.7.11.5)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IDH2" title="IDH2">IDH2</a></li> <li><a href="/wiki/IDH3A" title="IDH3A">IDH3A</a></li> <li><a href="/wiki/IDH3B" title="IDH3B">IDH3B</a></li> <li><a class="mw-selflink selflink">IDH3G</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(tyrosine_3-monooxygenase)_kinase" title="(tyrosine 3-monooxygenase) kinase">(tyrosine 3-monooxygenase) kinase</a> (EC 2.7.11.6)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STK4" title="STK4">STK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myosin-heavy-chain_kinase" title="Myosin-heavy-chain kinase">Myosin-heavy-chain kinase</a> (EC 2.7.11.7)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aurora_kinase" title="Aurora kinase">Aurora kinase</a> <ul><li><a href="/wiki/Aurora_A_kinase" class="mw-redirect" title="Aurora A kinase">Aurora A kinase</a></li> <li><a href="/wiki/Aurora_B_kinase" class="mw-redirect" title="Aurora B kinase">Aurora B kinase</a></li> <li><a href="/wiki/Aurora_C_kinase" class="mw-redirect" title="Aurora C kinase">Aurora C kinase</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fas-activated_serine/threonine_kinase" title="Fas-activated serine/threonine kinase">Fas-activated serine/threonine kinase</a> (EC 2.7.11.8)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FASTK" title="FASTK">FASTK</a></li> <li><a href="/wiki/STK10" title="STK10">STK10</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Goodpasture-antigen-binding_protein_kinase" title="Goodpasture-antigen-binding protein kinase">Goodpasture-antigen-binding protein kinase</a> (EC 2.7.11.9)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/I%CE%BAB_kinase" title="IκB kinase">IκB kinase</a> (EC 2.7.11.10)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CHUK" title="CHUK">CHUK</a></li> <li><a href="/wiki/IKK2" title="IKK2">IKK2</a></li> <li><a href="/wiki/TANK-binding_kinase_1" title="TANK-binding kinase 1">TBK1</a></li> <li><a href="/wiki/IKBKE" title="IKBKE">IKBKE</a></li> <li><a href="/wiki/IKBKG" title="IKBKG">IKBKG</a></li> <li><a href="/wiki/IKBKAP" title="IKBKAP">IKBKAP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protein_kinase_A" title="Protein kinase A">cAMP-dependent protein kinase</a> (EC 2.7.11.11)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Protein_kinase_A" title="Protein kinase A">Protein kinase A</a></li> <li><a href="/wiki/PRKACG" title="PRKACG">PRKACG</a></li> <li><a href="/wiki/PRKACB" title="PRKACB">PRKACB</a></li> <li><a href="/wiki/PRKACA" title="PRKACA">PRKACA</a></li> <li><a href="/wiki/PRKY" title="PRKY">PRKY</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CGMP-dependent_protein_kinase" title="CGMP-dependent protein kinase">cGMP-dependent protein kinase</a> (EC 2.7.11.12)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CGMP-dependent_protein_kinase" title="CGMP-dependent protein kinase">Protein kinase G</a></li> <li><a href="/wiki/PRKG1" title="PRKG1">PRKG1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protein_kinase_C" title="Protein kinase C">Protein kinase C</a> (EC 2.7.11.13)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Protein_kinase_C" title="Protein kinase C">Protein kinase C</a></li> <li><a href="/wiki/Protein_kinase_C_zeta_type" title="Protein kinase C zeta type">Protein kinase Cζ</a></li> <li><a href="/wiki/PKC_alpha" title="PKC alpha">PKC alpha</a></li> <li><a href="/wiki/PRKCB1" title="PRKCB1">PRKCB1</a></li> <li><a href="/wiki/PRKCD" title="PRKCD">PRKCD</a></li> <li><a href="/wiki/PRKCE" title="PRKCE">PRKCE</a></li> <li><a href="/wiki/PRKCH" title="PRKCH">PRKCH</a></li> <li><a href="/wiki/PRKCG" title="PRKCG">PRKCG</a></li> <li><a href="/wiki/PRKCI" title="PRKCI">PRKCI</a></li> <li><a href="/wiki/PRKCQ" title="PRKCQ">PRKCQ</a></li> <li><a href="/wiki/Protein_kinase_N1" title="Protein kinase N1">Protein kinase N1</a></li> <li><a href="/wiki/PKN2" title="PKN2">PKN2</a></li> <li><a href="/wiki/PKN3_(gene)" title="PKN3 (gene)">PKN3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Rhodopsin_kinase" title="Rhodopsin kinase">Rhodopsin kinase</a> (EC 2.7.11.14)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rhodopsin_kinase" title="Rhodopsin kinase">Rhodopsin kinase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta_adrenergic_receptor_kinase" class="mw-redirect" title="Beta adrenergic receptor kinase">Beta adrenergic receptor kinase</a> (EC 2.7.11.15)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beta_adrenergic_receptor_kinase" class="mw-redirect" title="Beta adrenergic receptor kinase">Beta adrenergic receptor kinase</a></li> <li><a href="/wiki/Beta_adrenergic_receptor_kinase-2" class="mw-redirect" title="Beta adrenergic receptor kinase-2">Beta adrenergic receptor kinase-2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/G_protein-coupled_receptor_kinase" title="G protein-coupled receptor kinase">G-protein coupled receptor kinases</a> (EC 2.7.11.16)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GRK4" title="GRK4">GRK4</a></li> <li><a href="/wiki/GRK5" title="GRK5">GRK5</a></li> <li><a href="/wiki/GRK6" title="GRK6">GRK6</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ca2%2B/calmodulin-dependent_protein_kinase" class="mw-redirect" title="Ca2+/calmodulin-dependent protein kinase">Ca2+/calmodulin-dependent</a> (EC 2.7.11.17)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BRSK2" title="BRSK2">BRSK2</a></li> <li><a href="/wiki/CAMK1" title="CAMK1">CAMK1</a></li> <li><a href="/w/index.php?title=CAMK1A&action=edit&redlink=1" class="new" title="CAMK1A (page does not exist)">CAMK1A</a></li> <li><a href="/w/index.php?title=CAMK1B&action=edit&redlink=1" class="new" title="CAMK1B (page does not exist)">CAMK1B</a></li> <li><a href="/wiki/CAMK1D" title="CAMK1D">CAMK1D</a></li> <li><a href="/w/index.php?title=CAMK1G&action=edit&redlink=1" class="new" title="CAMK1G (page does not exist)">CAMK1G</a></li> <li><a href="/wiki/Ca2%2B/calmodulin-dependent_protein_kinase_II" title="Ca2+/calmodulin-dependent protein kinase II">CAMK2</a></li> <li><a href="/wiki/CAMK2A" class="mw-redirect" title="CAMK2A">CAMK2A</a></li> <li><a href="/wiki/CAMK2B" title="CAMK2B">CAMK2B</a></li> <li><a href="/wiki/CAMK2D" title="CAMK2D">CAMK2D</a></li> <li><a href="/wiki/CAMK2G" title="CAMK2G">CAMK2G</a></li> <li><a href="/wiki/CAMK4" title="CAMK4">CAMK4</a></li> <li><a href="/wiki/Myosin_light-chain_kinase" title="Myosin light-chain kinase">MLCK</a></li> <li><a href="/wiki/CASK" title="CASK">CASK</a></li> <li><a href="/wiki/CHEK1" title="CHEK1">CHEK1</a></li> <li><a href="/wiki/CHEK2" title="CHEK2">CHEK2</a></li> <li><a href="/wiki/DAPK1" title="DAPK1">DAPK1</a></li> <li><a href="/wiki/DAPK2" title="DAPK2">DAPK2</a></li> <li><a href="/wiki/DAPK3" title="DAPK3">DAPK3</a></li> <li><a href="/wiki/STK11" title="STK11">STK11</a></li> <li><a href="/wiki/MAPKAPK2" title="MAPKAPK2">MAPKAPK2</a></li> <li><a href="/wiki/MAPKAPK3" title="MAPKAPK3">MAPKAPK3</a></li> <li><a href="/wiki/MAPKAPK5" title="MAPKAPK5">MAPKAPK5</a></li> <li><a href="/wiki/MARK1" title="MARK1">MARK1</a></li> <li><a href="/wiki/MARK2" title="MARK2">MARK2</a></li> <li><a href="/wiki/MARK3" title="MARK3">MARK3</a></li> <li><a href="/wiki/MARK4" title="MARK4">MARK4</a></li> <li><a href="/wiki/MELK" title="MELK">MELK</a></li> <li><a href="/wiki/MKNK1" title="MKNK1">MKNK1</a></li> <li><a href="/wiki/MKNK2" title="MKNK2">MKNK2</a></li> <li><a href="/wiki/NUAK1" title="NUAK1">NUAK1</a></li> <li><a href="/wiki/NUAK2" title="NUAK2">NUAK2</a></li> <li><a href="/wiki/OBSCN" class="mw-redirect" title="OBSCN">OBSCN</a></li> <li><a href="/wiki/PASK" title="PASK">PASK</a></li> <li><a href="/wiki/PHKG1" title="PHKG1">PHKG1</a></li> <li><a href="/wiki/PHKG2" title="PHKG2">PHKG2</a></li> <li><a href="/wiki/PIM1" title="PIM1">PIM1</a></li> <li><a href="/wiki/PIM2_(gene)" title="PIM2 (gene)">PIM2</a></li> <li><a href="/wiki/Protein_kinase_D1" title="Protein kinase D1">PKD1</a></li> <li><a href="/wiki/PRKD2" title="PRKD2">PRKD2</a></li> <li><a href="/wiki/PRKD3" title="PRKD3">PRKD3</a></li> <li><a href="/wiki/PSKH1" title="PSKH1">PSKH1</a></li> <li><a href="/wiki/SNF1LK2" title="SNF1LK2">SNF1LK2</a></li> <li><a href="/wiki/KIAA0999" title="KIAA0999">KIAA0999</a></li> <li><a href="/wiki/STK40" title="STK40">STK40</a></li> <li><a href="/wiki/SNF1LK" class="mw-redirect" title="SNF1LK">SNF1LK</a></li> <li><a href="/wiki/SNRK" title="SNRK">SNRK</a></li> <li><a href="/wiki/SPEG" title="SPEG">SPEG</a></li> <li><a href="/wiki/TSSK2" title="TSSK2">TSSK2</a></li> <li><a href="/wiki/Kalirin" title="Kalirin">Kalirin</a></li> <li><a href="/wiki/TRIB1" title="TRIB1">TRIB1</a></li> <li><a href="/wiki/TRIB2" title="TRIB2">TRIB2</a></li> <li><a href="/wiki/TRIB3" title="TRIB3">TRIB3</a></li> <li><a href="/wiki/TRIO_(gene)" title="TRIO (gene)">TRIO</a></li> <li><a href="/wiki/Titin" title="Titin">Titin</a></li> <li><a href="/wiki/DCLK1" title="DCLK1">DCLK1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myosin_light-chain_kinase" title="Myosin light-chain kinase">Myosin light-chain kinase</a> (EC 2.7.11.18)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MYLK" title="MYLK">MYLK</a></li> <li><a href="/wiki/MYLK2" title="MYLK2">MYLK2</a></li> <li><a href="/wiki/MYLK3" title="MYLK3">MYLK3</a></li> <li><a href="/wiki/MYLK4" title="MYLK4">MYLK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Phosphorylase_kinase" title="Phosphorylase kinase">Phosphorylase kinase</a> (EC 2.7.11.19)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Phosphorylase_kinase,_alpha_1" title="Phosphorylase kinase, alpha 1">PHKA1</a></li> <li><a href="/wiki/PHKA2" title="PHKA2">PHKA2</a></li> <li><a href="/wiki/PHKB" title="PHKB">PHKB</a></li> <li><a href="/wiki/PHKG1" title="PHKG1">PHKG1</a></li> <li><a href="/wiki/PHKG2" title="PHKG2">PHKG2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Elongation_factor_2_kinase" title="Elongation factor 2 kinase">Elongation factor 2 kinase</a> (EC 2.7.11.20)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EEF2K" title="EEF2K">EEF2K</a></li> <li><a href="/wiki/STK19" title="STK19">STK19</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polo_kinase" title="Polo kinase">Polo kinase</a> (EC 2.7.11.21)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PLK1" title="PLK1">PLK1</a></li> <li><a href="/wiki/PLK2" title="PLK2">PLK2</a></li> <li><a href="/wiki/PLK3" title="PLK3">PLK3</a></li> <li><a href="/wiki/PLK4" title="PLK4">PLK4</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Serine/threonine-specific_protein_kinases_(EC_2.7.11.21-EC_2.7.11.30)102" style="font-size:114%;margin:0 4em"><a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">Serine/threonine-specific protein kinases</a> (EC 2.7.11.21-EC 2.7.11.30)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polo_kinase" title="Polo kinase">Polo kinase</a> (EC 2.7.11.21)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PLK1" title="PLK1">PLK1</a></li> <li><a href="/wiki/PLK2" title="PLK2">PLK2</a></li> <li><a href="/wiki/PLK3" title="PLK3">PLK3</a></li> <li><a href="/wiki/PLK4" title="PLK4">PLK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cyclin-dependent_kinase" title="Cyclin-dependent kinase">Cyclin-dependent kinase</a> (EC 2.7.11.22)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cdk1" class="mw-redirect" title="Cdk1">CDK1</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_2" title="Cyclin-dependent kinase 2">CDK2</a></li> <li><a href="/wiki/CDKL2" title="CDKL2">CDKL2</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_3" title="Cyclin-dependent kinase 3">CDK3</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_4" title="Cyclin-dependent kinase 4">CDK4</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_5" title="Cyclin-dependent kinase 5">CDK5</a></li> <li><a href="/wiki/CDKL5" title="CDKL5">CDKL5</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_6" title="Cyclin-dependent kinase 6">CDK6</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_7" title="Cyclin-dependent kinase 7">CDK7</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_8" title="Cyclin-dependent kinase 8">CDK8</a></li> <li><a href="/wiki/CDK9" class="mw-redirect" title="CDK9">CDK9</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_10" title="Cyclin-dependent kinase 10">CDK10</a></li> <li><a href="/wiki/CDK12" title="CDK12">CDK12</a></li> <li><a href="/wiki/CDC2L5" class="mw-redirect" title="CDC2L5">CDC2L5</a></li> <li><a href="/wiki/PCTK1" title="PCTK1">PCTK1</a></li> <li><a href="/wiki/PCTK2" title="PCTK2">PCTK2</a></li> <li><a href="/wiki/PCTK3" title="PCTK3">PCTK3</a></li> <li><a href="/wiki/PFTK1" title="PFTK1">PFTK1</a></li> <li><a href="/wiki/CDC2L1" title="CDC2L1">CDC2L1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(RNA-polymerase)-subunit_kinase" title="(RNA-polymerase)-subunit kinase">(RNA-polymerase)-subunit kinase</a> (EC 2.7.11.23)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RPS6KA5" title="RPS6KA5">RPS6KA5</a></li> <li><a href="/wiki/RPS6KA4" title="RPS6KA4">RPS6KA4</a></li> <li><a href="/wiki/P70S6_kinase" class="mw-redirect" title="P70S6 kinase">P70S6 kinase</a></li> <li><a href="/wiki/P70-S6_Kinase_1" title="P70-S6 Kinase 1">P70-S6 Kinase 1</a></li> <li><a href="/wiki/RPS6KB2" title="RPS6KB2">RPS6KB2</a></li> <li><a href="/wiki/RPS6KA2" title="RPS6KA2">RPS6KA2</a></li> <li><a href="/wiki/RPS6KA3" title="RPS6KA3">RPS6KA3</a></li> <li><a href="/wiki/RPS6KA1" title="RPS6KA1">RPS6KA1</a></li> <li><a href="/wiki/RPS6KC1" title="RPS6KC1">RPS6KC1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">Mitogen-activated protein kinase</a> (EC 2.7.11.24)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Extracellular_signal-regulated_kinases" title="Extracellular signal-regulated kinases">Extracellular signal-regulated</a> <ul><li><a href="/wiki/MAPK1" title="MAPK1">MAPK1</a></li> <li><a href="/wiki/MAPK3" title="MAPK3">MAPK3</a></li> <li><a href="/wiki/MAPK4" title="MAPK4">MAPK4</a></li> <li><a href="/wiki/MAPK6" title="MAPK6">MAPK6</a></li> <li><a href="/wiki/MAPK7" title="MAPK7">MAPK7</a></li> <li><a href="/wiki/MAPK12" title="MAPK12">MAPK12</a></li> <li><a href="/wiki/MAPK15" title="MAPK15">MAPK15</a></li></ul></li> <li><a href="/wiki/C-Jun_N-terminal_kinases" title="C-Jun N-terminal kinases">C-Jun N-terminal</a> <ul><li><a href="/wiki/MAPK8" title="MAPK8">MAPK8</a></li> <li><a href="/wiki/Mitogen-activated_protein_kinase_9" title="Mitogen-activated protein kinase 9">MAPK9</a></li> <li><a href="/wiki/MAPK10" title="MAPK10">MAPK10</a></li></ul></li> <li><a href="/wiki/P38_mitogen-activated_protein_kinases" title="P38 mitogen-activated protein kinases">P38 mitogen-activated protein</a> <ul><li><a href="/wiki/MAPK11" title="MAPK11">MAPK11</a></li> <li><a href="/wiki/MAPK13" title="MAPK13">MAPK13</a></li> <li><a href="/wiki/MAPK14" title="MAPK14">MAPK14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MAP_kinase_kinase_kinase" title="MAP kinase kinase kinase">MAP3K</a> (EC 2.7.11.25)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MAP_kinase_kinase_kinase" title="MAP kinase kinase kinase">MAP kinase kinase kinases</a> <ul><li><a href="/wiki/MAP3K1" title="MAP3K1">MAP3K1</a></li> <li><a href="/wiki/MAP3K2" title="MAP3K2">MAP3K2</a></li> <li><a href="/wiki/MAP3K3" title="MAP3K3">MAP3K3</a></li> <li><a href="/wiki/MAP3K4" title="MAP3K4">MAP3K4</a></li> <li><a href="/wiki/ASK1" title="ASK1">MAP3K5</a></li> <li><a href="/w/index.php?title=MAP3K6&action=edit&redlink=1" class="new" title="MAP3K6 (page does not exist)">MAP3K6</a></li> <li><a href="/wiki/MAP3K7" title="MAP3K7">MAP3K7</a></li> <li><a href="/wiki/MAP3K8" title="MAP3K8">MAP3K8</a></li></ul></li> <li><a href="/wiki/C-Raf" title="C-Raf">RAFs</a> <ul><li><a href="/wiki/ARAF" title="ARAF">ARAF</a></li> <li><a href="/wiki/BRAF_(gene)" title="BRAF (gene)">BRAF</a></li> <li><a href="/wiki/KSR1" title="KSR1">KSR1</a></li> <li><a href="/wiki/KSR2" title="KSR2">KSR2</a></li></ul></li> <li><a href="/w/index.php?title=MLK_(kinase)&action=edit&redlink=1" class="new" title="MLK (kinase) (page does not exist)">MLKs</a> <ul><li><a href="/wiki/MAP3K12" title="MAP3K12">MAP3K12</a></li> <li><a href="/wiki/MAP3K13" title="MAP3K13">MAP3K13</a></li> <li><a href="/wiki/MAP3K9" title="MAP3K9">MAP3K9</a></li> <li><a href="/wiki/MAP3K10" title="MAP3K10">MAP3K10</a></li> <li><a href="/wiki/MAP3K11" title="MAP3K11">MAP3K11</a></li> <li><a href="/wiki/MAP3K7" title="MAP3K7">MAP3K7</a></li> <li><a href="/wiki/ZAK" title="ZAK">ZAK</a></li></ul></li> <li><a href="/wiki/Cell_division_cycle_7-related_protein_kinase" title="Cell division cycle 7-related protein kinase">CDC7</a></li> <li><a href="/wiki/MAP3K14" title="MAP3K14">MAP3K14</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tau-protein_kinase" title="Tau-protein kinase">Tau-protein kinase</a> (EC 2.7.11.26)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TPK1" title="TPK1">TPK1</a></li> <li><a href="/wiki/TTK_(gene)" title="TTK (gene)">TTK</a></li> <li><a href="/wiki/GSK-3" title="GSK-3">GSK-3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(acetyl-CoA_carboxylase)_kinase" title="(acetyl-CoA carboxylase) kinase">(acetyl-CoA carboxylase) kinase</a> (EC 2.7.11.27)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tropomyosin_kinase" title="Tropomyosin kinase">Tropomyosin kinase</a> (EC 2.7.11.28)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Low-density-lipoprotein_receptor_kinase" title="Low-density-lipoprotein receptor kinase">Low-density-lipoprotein receptor kinase</a> (EC 2.7.11.29)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_protein_serine/threonine_kinase" title="Receptor protein serine/threonine kinase">Receptor protein serine/threonine kinase</a> (EC 2.7.11.30)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bone_morphogenetic_protein_receptors" class="mw-redirect" title="Bone morphogenetic protein receptors">Bone morphogenetic protein receptors</a> <ul><li><a href="/wiki/Bone_morphogenetic_protein_receptor,_type_1" title="Bone morphogenetic protein receptor, type 1">BMPR1</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">BMPR1A</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">BMPR1B</a></li> <li><a href="/wiki/BMPR2" title="BMPR2">BMPR2</a></li></ul></li> <li><a href="/wiki/ACVR1" title="ACVR1">ACVR1</a></li> <li><a href="/wiki/ACVR1B" title="ACVR1B">ACVR1B</a></li> <li><a href="/wiki/ACVR1C" title="ACVR1C">ACVR1C</a></li> <li><a href="/wiki/ACVR2A" title="ACVR2A">ACVR2A</a></li> <li><a href="/wiki/ACVR2B" title="ACVR2B">ACVR2B</a></li> <li><a href="/wiki/ACVRL1" title="ACVRL1">ACVRL1</a></li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone_receptor" title="Anti-Müllerian hormone receptor">Anti-Müllerian hormone receptor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Dual-specificity_kinases_(EC_2.7.12)102" style="font-size:114%;margin:0 4em"><a href="/wiki/Dual-specificity_kinase" title="Dual-specificity kinase">Dual-specificity kinases</a> (EC 2.7.12)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="MAP2K49" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mitogen-activated_protein_kinase_kinase" title="Mitogen-activated protein kinase kinase">MAP2K</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MAP2K1" title="MAP2K1">MAP2K1</a></li> <li><a href="/wiki/MAP2K2" title="MAP2K2">MAP2K2</a></li> <li><a href="/wiki/MAP2K3" title="MAP2K3">MAP2K3</a></li> <li><a href="/wiki/MAP2K4" title="MAP2K4">MAP2K4</a></li> <li><a href="/wiki/MAP2K5" title="MAP2K5">MAP2K5</a></li> <li><a href="/wiki/MAP2K6" title="MAP2K6">MAP2K6</a></li> <li><a href="/wiki/MAP2K7" title="MAP2K7">MAP2K7</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Enzymes56" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes56" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 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