Sodium Glucose Transporter 2 (SGLT2) Inhibition does not Pro

<!DOCTYPE html> <html> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Sodium Glucose Transporter 2 (SGLT2) Inhibition does not Pro | 15869</title> <meta name="keywords" content="Jespersen NR*, Lassen TR, Hjortbak MV, Støttrup NB and Bøtker HE, Ischemic-reperfusion injury; SGLT2- inhibition; Cardioprotection; Mitochondrial respiration"/> <meta name="description" content="Background: The Sodium Glucose Transporter 2 (SGLT2)-inhibitor, empagliflozin, reduces death from cardiovascular causes. We hypothesized that the mechanism..15869"/> <meta name="citation_publisher" content="Walsh Medical Media" /> <meta name="citation_journal_title" content="Cardiovascular Pharmacology: Open Access"> <meta name="citation_title" content="Sodium Glucose Transporter 2 (SGLT2) Inhibition does not Protect the Myocardium from Acute Ischemic Reperfusion Injury but Modulates Post- Ischemic Mitochondrial Function"> <meta name="citation_author" content="Jespersen NR" /> <meta name="citation_author" content="Lassen TR" /> <meta name="citation_author" content="Hjortbak MV" /> <meta name="citation_author" content="Støttrup NB" /> <meta name="citation_author" content="Bøtker HE" /> <meta name="citation_year" content="2017"> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="2"> <meta name="citation_doi" content="10.4172/2329-6607.1000210"> <meta name="citation_issn" content="2329-6607"> <meta name="citation_online_date" content="2019/02/13" /> <meta name="citation_firstpage" content="1"> <meta name="citation_lastpage" content="3"> <meta name="citation_abstract" content="Background: The Sodium Glucose Transporter 2 (SGLT2)-inhibitor, empagliflozin, reduces death from cardiovascular causes. We hypothesized that the mechanism involved direct protection against Ischemia- Reperfusion (IR) injury and improved post-ischemic mitochondrial function. Methods: We examined infarct size (series I) and mitochondrial respiration (series II) in four groups of isolated perfused hearts from male Wistar rats: Sham-operated hearts (Sham group), IR-injured hearts (IR group), hearts treated with ischemic preconditioning (IPC) by 2 × 5 min. cycles of IR prior to sustained ischemia (IPC group), and hearts co-perfused with 2.14 mg/l of empagliflozin 10 min. prior to sustained ischemia (EMPA group). Results: In contrast to IPC, empagliflozin did not reduce infarct size compared to the IR group, when given 10 min prior to the acute myocardial infarction. Empagliflozin improved post-ischemic complex I+II respiration compared to the IR group. This improvement was similar to IPC. In contrast to the improved complex I respiration by IPC, empagliflozin mainly improved complex II respiration. Empagliflozin hearts had significantly higher respiration in oligomycin induced state 4 than the sham and IR group, indicating that empagliflozin modulates the inner mitochondrial membrane. Conclusion: In conclusion, empagliflozin yielded no acute cardioprotection in the isolated perfused non-diabetic rat heart. Empagliflozin mainly improved complex II respiration and increased permeability of the inner membrane, providing a potential explanation for the positive long-term effects observed in post infarction myocardial dysfunction. 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Aquaculture </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/biochemistry-journals.html" title="Click here"> Biochemistry </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/bioinformatics-and-systems-biology-journals.html" title="Click here"> Bioinformatics & Systems Biology </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/business-and-management-journals.html" title="Click here"> Business & Management </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/chemistry-journals.html" title="Click here"> Chemistry </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/clinical-sciences-journals.html" title="Click here"> Clinical Sciences </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/engineering-journals.html" title="Click here"> Engineering </a></li> <li><i 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Psychology </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/nursing-and-health-care-journals.html" title="Click here"> Nursing & Health Care </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/pharmaceutical-sciences-journals.html" title="Click here"> Pharmaceutical Sciences </a></li> </ul> </div> <div class="card-footer custom-card-footer text-end"> <a href="https://www.walshmedicalmedia.com/open-access-journals-list.html">View More <i class="fa fa-long-arrow-right" aria-hidden="true"></i></a> </div> </div>  </div> <div class="col-lg-9"> <h2 class="mt-3">Abstract</h2> <h3>Sodium Glucose Transporter 2 (SGLT2) Inhibition does not Protect the Myocardium from Acute Ischemic Reperfusion Injury but Modulates Post- Ischemic Mitochondrial Function</h3> <p> <i class="fas fa-user"></i> Jespersen NR*, Lassen TR, Hjortbak MV, Støttrup NB and Bøtker HE </p> <p><p><strong>Background: </strong>The Sodium Glucose Transporter 2 (SGLT2)-inhibitor, empagliflozin, reduces death from cardiovascular causes. We hypothesized that the mechanism involved direct protection against Ischemia- Reperfusion (IR) injury and improved post-ischemic mitochondrial function.</p> <p><strong>Methods:</strong> We examined infarct size (series I) and mitochondrial respiration (series II) in four groups of isolated perfused hearts from male Wistar rats: Sham-operated hearts (Sham group), IR-injured hearts (IR group), hearts treated with ischemic preconditioning (IPC) by 2 × 5 min. cycles of IR prior to sustained ischemia (IPC group), and hearts co-perfused with 2.14 mg/l of empagliflozin 10 min. prior to sustained ischemia (EMPA group).</p> <p><strong>Results:</strong> In contrast to IPC, empagliflozin did not reduce infarct size compared to the IR group, when given 10 min prior to the acute myocardial infarction. Empagliflozin improved post-ischemic complex I+II respiration compared to the IR group. This improvement was similar to IPC. In contrast to the improved complex I respiration by IPC, empagliflozin mainly improved complex II respiration. Empagliflozin hearts had significantly higher respiration in oligomycin induced state 4 than the sham and IR group, indicating that empagliflozin modulates the inner mitochondrial membrane.</p> <p><strong>Conclusion:</strong> In conclusion, empagliflozin yielded no acute cardioprotection in the isolated perfused non-diabetic rat heart. Empagliflozin mainly improved complex II respiration and increased permeability of the inner membrane, providing a potential explanation for the positive long-term effects observed in post infarction myocardial dysfunction.</p> </p> <p class="mb-1 font-size-3 text-muted"> </p> <nav class="nav a-pl-0"> <a href="https://www.walshmedicalmedia.com/open-access/sodium-glucose-transporter-2-sglt2-inhibition-does-not-protect-the-myocardium-from-acute-ischemic-reperfusion-injury-but-15869.html" title="Click here" class="nav-link text-danger"><i class="fas fa-file-code"></i> HTML</a> <a href="https://www.walshmedicalmedia.com/open-access/sodium-glucose-transporter-2-sglt2-inhibition-does-not-protect-themyocardium-from-acute-ischemic-reperfusion-injury-but-modulates-2329-6607-1000210.pdf" title="Click here" class="nav-link text-success"><i class="fas fa-file-pdf"></i> PDF</a> </nav> <div class="nav social-icons align-items-center"> <p class="m-0">Share this article:</p> <a class="nav-link" title="Click here" target="_blank" rel="noopener" href="https://www.facebook.com/sharer.php?u=https://www.walshmedicalmedia.com/abstract/sodium-glucose-transporter-2-sglt2-inhibition-does-not-protect-the-myocardium-from-acute-ischemic-reperfusion-injury-but-15869.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Click here" target="_blank" rel="noopener" href="https://twitter.com/share?url=https://www.walshmedicalmedia.com/abstract/sodium-glucose-transporter-2-sglt2-inhibition-does-not-protect-the-myocardium-from-acute-ischemic-reperfusion-injury-but-15869.html"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Click here" target="_blank" rel="noopener" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.walshmedicalmedia.com/abstract/sodium-glucose-transporter-2-sglt2-inhibition-does-not-protect-the-myocardium-from-acute-ischemic-reperfusion-injury-but-15869.html"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Click here" target="_blank" rel="noopener" href="https://plus.google.com/share?url=https://www.walshmedicalmedia.com/abstract/sodium-glucose-transporter-2-sglt2-inhibition-does-not-protect-the-myocardium-from-acute-ischemic-reperfusion-injury-but-15869.html"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section>   <div class="whatup"> <ul> <li><a href="tel:+44 1687550021">+44 1687550021 <i class="fab fa-whatsapp" aria-hidden="true"></i></a></li> </ul> </div> <section> <footer> <div class="custom-footer"> <div class="container"> <div class="row"> <div class="col-md-3 md-margin-bottom-40"> <a download="" href="/"><img id="logo-footer" src="/assets/images/footer-logo.png" alt="Walsh Medical Media" width="220px;"></a> <p class="py-3">Walsh Medical Media is a global leader in open access publishing, dedicated to advancing the frontiers of science and technology. 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Sodium Glucose Transporter 2 (SGLT2) Inhibition does not Pro | 15869