Capella - RNAi Innovation and News

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.wpb_animate_when_almost_visible { opacity: 1; }</style></noscript><style type="text/css">/** Tuesday 30th July 2024 17:14:48 UTC (core) **//** THIS FILE IS AUTOMATICALLY GENERATED - DO NOT MAKE MANUAL EDITS! **//** Custom CSS should be added to Mega Menu > Menu Themes > Custom Styling **/.mega-menu-last-modified-1722359688 { content: 'Tuesday 30th July 2024 17:14:48 UTC'; }#mega-menu-wrap-max_mega_menu_1, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 span.mega-menu-badge {transition: none;border-radius: 0;box-shadow: none;background: none;border: 0;bottom: auto;box-sizing: border-box;clip: auto;color: #666;display: block;float: none;font-family: inherit;font-size: 14px;height: auto;left: auto;line-height: 1.7;list-style-type: none;margin: 0;min-height: auto;max-height: none;min-width: auto;max-width: none;opacity: 1;outline: none;overflow: visible;padding: 0;position: relative;pointer-events: auto;right: auto;text-align: left;text-decoration: none;text-indent: 0;text-transform: none;transform: none;top: auto;vertical-align: baseline;visibility: inherit;width: auto;word-wrap: break-word;white-space: normal;}#mega-menu-wrap-max_mega_menu_1:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link:before, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 span.mega-menu-badge:before, #mega-menu-wrap-max_mega_menu_1:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 ul.mega-sub-menu:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-row:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-column:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link:after, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 span.mega-menu-badge:after {display: none;}#mega-menu-wrap-max_mega_menu_1 {border-radius: 0;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 {background: #222;}}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-menu-toggle:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block a:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block .mega-search input[type=text]:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block button.mega-toggle-animated:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 a:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 input:focus, #mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation #mega-menu-max_mega_menu_1 li.mega-menu-item a.mega-menu-link:focus {outline: 3px solid #109cde;outline-offset: -3px;}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation .mega-toggle-block button.mega-toggle-animated:focus {outline-offset: 2px;}#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation > li.mega-menu-item > a.mega-menu-link:focus {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1.mega-keyboard-navigation > li.mega-menu-item > a.mega-menu-link:focus {color: #fff;background: #333;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 {visibility: visible;text-align: left;padding: 0px 0px 0px 0px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link {cursor: pointer;display: inline;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group {vertical-align: middle;display: inline-block;transition: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group .mega-menu-title, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group .mega-menu-description {transition: none;line-height: 1.5;display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link .mega-description-group .mega-menu-description {font-style: italic;font-size: 0.8em;text-transform: none;font-weight: normal;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link {display: flex;align-items: center;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link:before {flex: 0 0 auto;align-self: flex-start;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-tabbed.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link {display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-top > a.mega-menu-link {display: table-cell;vertical-align: middle;line-height: initial;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-top > a.mega-menu-link:before {display: block;margin: 0 0 6px 0;text-align: center;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-top > a.mega-menu-link > span.mega-title-below {display: inline-block;transition: none;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-icon-top > a.mega-menu-link {display: block;line-height: 40px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-icon-top > a.mega-menu-link:before {display: inline-block;margin: 0 6px 0 0;text-align: left;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-icon-right > a.mega-menu-link:before {float: right;margin: 0 0 0 6px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-animating > ul.mega-sub-menu {pointer-events: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-disable-link > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu li.mega-disable-link > a.mega-menu-link {cursor: inherit;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-disable-link > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > li.mega-menu-item-has-children.mega-disable-link > a.mega-menu-link {cursor: pointer;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 p {margin-bottom: 10px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 input, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 img {max-width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item > ul.mega-sub-menu {display: block;visibility: hidden;opacity: 1;pointer-events: auto;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item > ul.mega-sub-menu {display: none;visibility: visible;opacity: 1;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu.mega-menu-item.mega-toggle-on ul.mega-sub-menu {display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu.mega-menu-item.mega-toggle-on li.mega-hide-sub-menu-on-mobile > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-sub-menu-on-mobile > ul.mega-sub-menu {display: none;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"] li.mega-menu-item > ul.mega-sub-menu {opacity: 0;transition: opacity 200ms ease-in, visibility 200ms ease-in;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"].mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"].mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"] li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade"] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu {opacity: 1;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-menu-megamenu > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu {opacity: 0;transform: translate(0, 10px);transition: opacity 200ms ease-in, transform 200ms ease-in, visibility 200ms ease-in;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"].mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"].mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="fade_up"] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu {opacity: 1;transform: translate(0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-menu-megamenu > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-menu-flyout ul.mega-sub-menu {transform: translate(0, 10px);transition: transform 200ms ease-in, visibility 200ms ease-in;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"].mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"].mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1[data-effect="slide_up"] li.mega-menu-item.mega-menu-megamenu.mega-toggle-on ul.mega-sub-menu {transform: translate(0, 0);}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-collapse-children > ul.mega-sub-menu {display: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-collapse-children.mega-toggle-on > ul.mega-sub-menu {display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-no-js li.mega-menu-item:hover > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-no-js li.mega-menu-item:focus > ul.mega-sub-menu, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-toggle-on > ul.mega-sub-menu {visibility: visible;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu ul.mega-sub-menu {visibility: inherit;opacity: 1;display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-1-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-2-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-3-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-4-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-5-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-menu-megamenu ul.mega-sub-menu li.mega-6-columns > ul.mega-sub-menu > li.mega-menu-item {float: left;width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item a[class^='dashicons']:before {font-family: dashicons;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item a.mega-menu-link:before {display: inline-block;font: inherit;font-family: dashicons;position: static;margin: 0 6px 0 0px;vertical-align: top;-webkit-font-smoothing: antialiased;-moz-osx-font-smoothing: grayscale;color: inherit;background: transparent;height: auto;width: auto;top: auto;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-hide-text a.mega-menu-link:before {margin: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item.mega-hide-text li.mega-menu-item a.mega-menu-link:before {margin: 0 6px 0 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-left.mega-toggle-on > a.mega-menu-link {border-radius: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-right > ul.mega-sub-menu {right: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-align-bottom-right.mega-toggle-on > a.mega-menu-link {border-radius: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-menu-item {position: static;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item {margin: 0 0px 0 0;display: inline-block;height: auto;vertical-align: middle;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-right {float: right;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-right {margin: 0 0 0 0px;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-float-left {float: left;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item > a.mega-menu-link:hover {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-toggle-on > a.mega-menu-link {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-toggle-on > a.mega-menu-link {color: #fff;background: #333;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-ancestor > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-page-ancestor > a.mega-menu-link {background: #333;color: #fff;font-weight: normal;text-decoration: none;border-color: #fff;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-menu-ancestor > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-current-page-ancestor > a.mega-menu-link {color: #fff;background: #333;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item > a.mega-menu-link {line-height: 40px;height: 40px;padding: 0px 10px 0px 10px;vertical-align: baseline;width: auto;display: block;color: #fff;text-transform: none;text-decoration: none;text-align: left;text-decoration: none;background: rgba(0, 0, 0, 0);border: 0;border-radius: 0;font-family: inherit;font-size: 14px;font-weight: normal;outline: none;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-multi-line > a.mega-menu-link {line-height: inherit;display: table-cell;vertical-align: middle;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-multi-line > a.mega-menu-link br {display: none;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item {display: list-item;margin: 0;clear: both;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item.mega-item-align-right {float: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-item > a.mega-menu-link {border-radius: 0;border: 0;margin: 0;line-height: 40px;height: 40px;padding: 0 10px;background: transparent;text-align: left;color: #fff;font-size: 14px;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row {width: 100%;float: left;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row .mega-menu-column {float: left;min-height: 1px;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-1 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-2 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-2 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-3 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-3 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-3 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-4 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-4 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-4 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-4 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-5 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-5 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-5 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-5 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-5 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-6 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-6 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-6 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-6 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-6 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-6 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-7 {width: 14.28571%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-7 {width: 28.57143%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-7 {width: 42.85714%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-7 {width: 57.14286%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-7 {width: 71.42857%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-7 {width: 85.71429%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-7 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-8 {width: 12.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-8 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-8 {width: 37.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-8 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-8 {width: 62.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-8 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-8 {width: 87.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-8 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-9 {width: 11.11111%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-9 {width: 22.22222%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-9 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-9 {width: 44.44444%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-9 {width: 55.55556%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-9 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-9 {width: 77.77778%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-9 {width: 88.88889%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-9 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-10 {width: 10%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-10 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-10 {width: 30%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-10 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-10 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-10 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-10 {width: 70%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-10 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-10 {width: 90%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-10-of-10 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-11 {width: 9.09091%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-11 {width: 18.18182%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-11 {width: 27.27273%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-11 {width: 36.36364%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-11 {width: 45.45455%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-11 {width: 54.54545%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-11 {width: 63.63636%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-11 {width: 72.72727%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-11 {width: 81.81818%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-10-of-11 {width: 90.90909%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-11-of-11 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-1-of-12 {width: 8.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-2-of-12 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-3-of-12 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-4-of-12 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-5-of-12 {width: 41.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-6-of-12 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-7-of-12 {width: 58.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-8-of-12 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-9-of-12 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-10-of-12 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-11-of-12 {width: 91.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-columns-12-of-12 {width: 100%;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row > ul.mega-sub-menu > li.mega-menu-column {width: 100%;clear: both;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-row .mega-menu-column > ul.mega-sub-menu > li.mega-menu-item {padding: 15px 15px 15px 15px;width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu {z-index: 999;border-radius: 0;background: #f1f1f1;border: 0;padding: 0px 0px 0px 0px;position: absolute;width: 100%;max-width: none;left: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu {float: left;position: static;width: 100%;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-1 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-2 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-2 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-3 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-3 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-3 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-4 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-4 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-4 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-4 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-5 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-5 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-5 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-5 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-5 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-6 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-6 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-6 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-6 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-6 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-6 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-7 {width: 14.28571%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-7 {width: 28.57143%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-7 {width: 42.85714%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-7 {width: 57.14286%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-7 {width: 71.42857%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-7 {width: 85.71429%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-7 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-8 {width: 12.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-8 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-8 {width: 37.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-8 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-8 {width: 62.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-8 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-8 {width: 87.5%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-8 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-9 {width: 11.11111%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-9 {width: 22.22222%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-9 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-9 {width: 44.44444%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-9 {width: 55.55556%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-9 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-9 {width: 77.77778%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-9 {width: 88.88889%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-9 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-10 {width: 10%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-10 {width: 20%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-10 {width: 30%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-10 {width: 40%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-10 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-10 {width: 60%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-10 {width: 70%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-10 {width: 80%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-10 {width: 90%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-10-of-10 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-11 {width: 9.09091%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-11 {width: 18.18182%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-11 {width: 27.27273%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-11 {width: 36.36364%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-11 {width: 45.45455%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-11 {width: 54.54545%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-11 {width: 63.63636%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-11 {width: 72.72727%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-11 {width: 81.81818%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-10-of-11 {width: 90.90909%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-11-of-11 {width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-1-of-12 {width: 8.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-2-of-12 {width: 16.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-3-of-12 {width: 25%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-4-of-12 {width: 33.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-5-of-12 {width: 41.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-6-of-12 {width: 50%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-7-of-12 {width: 58.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-8-of-12 {width: 66.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-9-of-12 {width: 75%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-10-of-12 {width: 83.33333%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-11-of-12 {width: 91.66667%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-columns-12-of-12 {width: 100%;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu .mega-description-group .mega-menu-description {margin: 5px 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item ul.mega-sub-menu {clear: both;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {margin-left: 10px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu ul.mega-sub-menu ul.mega-sub-menu {margin-left: 10px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item {color: #666;font-family: inherit;font-size: 14px;display: block;float: left;clear: none;padding: 15px 15px 15px 15px;vertical-align: top;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item.mega-menu-clear, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item.mega-menu-clear {clear: left;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title {color: #555;font-family: inherit;font-size: 16px;text-transform: uppercase;text-decoration: none;font-weight: bold;text-align: left;margin: 0px 0px 0px 0px;padding: 0px 0px 5px 0px;vertical-align: top;display: block;visibility: inherit;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item h4.mega-block-title:hover {border-color: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link {/* Mega Menu > Menu Themes > Mega Menus > Second Level Menu Items */color: #555;font-family: inherit;font-size: 16px;text-transform: uppercase;text-decoration: none;font-weight: bold;text-align: left;margin: 0px 0px 0px 0px;padding: 0px 0px 0px 0px;vertical-align: top;display: block;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover {border-color: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus {/* Mega Menu > Menu Themes > Mega Menus > Second Level Menu Items (Hover) */color: #555;font-weight: bold;text-decoration: none;background: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover > span.mega-title-below, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover > span.mega-title-below, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus > span.mega-title-below, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus > span.mega-title-below {text-decoration: none;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link {/* Mega Menu > Menu Themes > Mega Menus > Third Level Menu Items */color: #666;font-family: inherit;font-size: 14px;text-transform: none;text-decoration: none;font-weight: normal;text-align: left;margin: 0px 0px 0px 0px;padding: 0px 0px 0px 0px;vertical-align: top;display: block;border: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover {border-color: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item.mega-icon-left.mega-has-description.mega-has-icon > a.mega-menu-link {display: flex;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:focus, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item li.mega-menu-item > a.mega-menu-link:focus {/* Mega Menu > Menu Themes > Mega Menus > Third Level Menu Items (Hover) */color: #666;font-weight: normal;text-decoration: none;background: rgba(0, 0, 0, 0);}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu {border: 0;padding: 10px;border-radius: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-menu-item {width: 100%;clear: both;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link {color: #666;font-family: inherit;font-size: 14px;text-transform: none;text-decoration: none;font-weight: normal;margin: 0;border: 0;padding: 0px 0px 0px 0px;vertical-align: top;display: block;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu.mega-no-headers > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item > a.mega-menu-link:focus {color: #666;font-weight: normal;text-decoration: none;background: rgba(0, 0, 0, 0);}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu {z-index: 999;position: absolute;width: 250px;max-width: none;padding: 0px 0px 0px 0px;border: 0;background: #f1f1f1;border-radius: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu {float: left;position: static;width: 100%;padding: 0;border: 0;border-radius: 0;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item {clear: both;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link {display: block;background: #f1f1f1;color: #666;font-family: inherit;font-size: 14px;font-weight: normal;padding: 0px 10px 0px 10px;line-height: 35px;text-decoration: none;text-transform: none;vertical-align: baseline;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:first-child > a.mega-menu-link {border-top-left-radius: 0px;border-top-right-radius: 0px;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:first-child > a.mega-menu-link {border-top-left-radius: 0;border-top-right-radius: 0;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:last-child > a.mega-menu-link {border-bottom-right-radius: 0px;border-bottom-left-radius: 0px;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item:last-child > a.mega-menu-link {border-bottom-right-radius: 0;border-bottom-left-radius: 0;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link:hover, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item a.mega-menu-link:focus {background: #ddd;font-weight: normal;text-decoration: none;color: #666;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {position: absolute;left: 100%;top: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {position: static;left: 0;width: 100%;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu a.mega-menu-link {padding-left: 20px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-flyout ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu ul.mega-sub-menu a.mega-menu-link {padding-left: 30px;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator:after {content: '\f140';font-family: dashicons;font-weight: normal;display: inline-block;margin: 0 0 0 6px;vertical-align: top;-webkit-font-smoothing: antialiased;-moz-osx-font-smoothing: grayscale;transform: rotate(0);color: inherit;position: relative;background: transparent;height: auto;width: auto;right: auto;line-height: inherit;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {display: inline;height: auto;width: auto;background: transparent;position: relative;pointer-events: auto;left: auto;min-width: auto;line-height: inherit;color: inherit;font-size: inherit;padding: 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {float: right;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-collapse-children.mega-toggle-on > a.mega-menu-link > span.mega-indicator:after {content: '\f142';}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {float: right;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-toggle-on > a.mega-menu-link > span.mega-indicator:after {content: '\f142';}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-hide-sub-menu-on-mobile > a.mega-menu-link > span.mega-indicator {display: none;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-megamenu:not(.mega-menu-tabbed) li.mega-menu-item-has-children:not(.mega-collapse-children) > a.mega-menu-link > span.mega-indicator, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-item-has-children.mega-hide-arrow > a.mega-menu-link > span.mega-indicator {display: none;}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout li.mega-menu-item a.mega-menu-link > span.mega-indicator:after {content: '\f139';}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link {text-align: right;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link > span.mega-indicator {float: left;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link > span.mega-indicator:after {content: '\f141';margin: 0 6px 0 0;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right li.mega-menu-item a.mega-menu-link:before {float: right;margin: 0 0 0 6px;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-menu-flyout.mega-align-bottom-right ul.mega-sub-menu li.mega-menu-item ul.mega-sub-menu {left: -100%;top: 0;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1.mega-menu-accordion > li.mega-menu-item-has-children > a.mega-menu-link > span.mega-indicator {float: right;}}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li[class^='mega-lang-item'] > a.mega-menu-link > img {display: inline;}#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link > img.wpml-ls-flag, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 a.mega-menu-link > img.iclflag {display: inline;margin-right: 8px;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-on-mobile, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-hide-on-mobile, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item.mega-hide-on-mobile {display: none;}}@media only screen and (min-width: 1001px) {#mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 li.mega-hide-on-desktop, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu > li.mega-hide-on-desktop, #mega-menu-wrap-max_mega_menu_1 #mega-menu-max_mega_menu_1 > li.mega-menu-megamenu > ul.mega-sub-menu li.mega-menu-column > ul.mega-sub-menu > li.mega-menu-item.mega-hide-on-desktop {display: none;}}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1:after {content: "";display: table;clear: both;}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle {display: none;z-index: 1;cursor: pointer;background: #222;border-radius: 2px 2px 2px 2px;line-height: 40px;height: 40px;text-align: left;user-select: none;-webkit-tap-highlight-color: transparent;outline: none;white-space: nowrap;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle img {max-width: 100%;padding: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle {display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right {display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;-ms-flex-preferred-size: 33.33%;-webkit-flex-basis: 33.33%;flex-basis: 33.33%;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left {-webkit-box-flex: 1;-ms-flex: 1;-webkit-flex: 1;flex: 1;-webkit-box-pack: start;-ms-flex-pack: start;-webkit-justify-content: flex-start;justify-content: flex-start;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left .mega-toggle-block {margin-left: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-left .mega-toggle-block:only-child {margin-right: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center {-webkit-box-pack: center;-ms-flex-pack: center;-webkit-justify-content: center;justify-content: center;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-center .mega-toggle-block {margin-left: 3px;margin-right: 3px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right {-webkit-box-flex: 1;-ms-flex: 1;-webkit-flex: 1;flex: 1;-webkit-box-pack: end;-ms-flex-pack: end;-webkit-justify-content: flex-end;justify-content: flex-end;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right .mega-toggle-block {margin-right: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-blocks-right .mega-toggle-block:only-child {margin-left: 6px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block {display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;height: 100%;outline: 0;-webkit-align-self: center;-ms-flex-item-align: center;align-self: center;-ms-flex-negative: 0;-webkit-flex-shrink: 0;flex-shrink: 0;}@media only screen and (max-width: 1000px) {#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle + #mega-menu-max_mega_menu_1 {background: #222;padding: 0px 0px 0px 0px;display: none;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open + #mega-menu-max_mega_menu_1 {display: block;}}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle {/** Push menu onto new line **/}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 {/*! * Hamburgers * @description Tasty CSS-animated hamburgers * @author Jonathan Suh @jonsuh * @site https://jonsuh.com/hamburgers * @link https://github.com/jonsuh/hamburgers */cursor: pointer;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated {padding: 0;display: -webkit-box;display: -ms-flexbox;display: -webkit-flex;display: flex;cursor: pointer;transition-property: opacity, filter;transition-duration: 0.15s;transition-timing-function: linear;font: inherit;color: inherit;text-transform: none;background-color: transparent;border: 0;margin: 0;overflow: visible;transform: scale(0.8);align-self: center;outline: 0;background: none;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-box {width: 40px;height: 24px;display: inline-block;position: relative;outline: 0;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner {display: block;top: 50%;margin-top: -2px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::before, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::after {width: 40px;height: 4px;background-color: #797979;border-radius: 4px;position: absolute;transition-property: transform;transition-duration: 0.15s;transition-timing-function: ease;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::before, #mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::after {content: "";display: block;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::before {top: -10px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-inner::after {bottom: -10px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner {top: 2px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::before {top: 10px;transition-property: transform, opacity;transition-timing-function: ease;transition-duration: 0.15s;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::after {top: 20px;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner {transform: translate3d(0, 10px, 0) rotate(45deg);}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::before {transform: rotate(-45deg) translate3d(-5.71429px, -6px, 0);opacity: 0;}#mega-menu-wrap-max_mega_menu_1 .mega-menu-toggle.mega-menu-open .mega-toggle-block-1 .mega-toggle-animated-slider .mega-toggle-animated-inner::after {transform: translate3d(0, -20px, 0) rotate(-90deg);}#mega-menu-wrap-max_mega_menu_1 {clear: both;}</style> </head> <body class="page-template page-template-blog-small-image page-template-blog-small-image-php page page-id-26028 page-child parent-pageid-24993 mega-menu-max-mega-menu-1 qode-child-theme-ver-1.0.0 qode-theme-ver-10.1.1 wpb-js-composer js-comp-ver-5.7 vc_responsive" itemscope itemtype="https://schema.org/WebPage">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-WJ29M6J" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="ajax_loader"> <div class="ajax_loader_1"><div class="pulse"></div></div> </div> <div class="wrapper"> <div class="wrapper_inner">   <header class=" scroll_header_top_area stick menu_bottom 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href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> <p></p> </div> <p></p></span></div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1513 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Czech Republic </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com/alnylam-czech-republic" >Čeština</a > </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--116 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" 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field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com/alnylam-ireland">English</a> </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--122 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Italy </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.it/">Italiano</a> </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--124 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Japan </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.jp/">日本語</a> </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--109 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Luxembourg </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com/alnylam-luxembourg-french" >Français</a > </div> <div class="field--item"> <a href="https://www.alnylam.com/alnylam-luxembourg-german"> Deutsch</a > </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--111 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > Netherlands </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com/alnylam-netherlands" >Nederlands</a > </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--113 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label 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<p></p> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--123 paragraph--view-mode--default" > <div class="language-switcher-main"> <span class="label-text" ><p></p> <div class="field field--name-field-label field--type-string field--label-hidden field--item" > United Kingdom </div> <p><span class="link-text"></span></p> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items" > <div class="field--item"> <a href="https://www.alnylam.com/alnylam-uk">English</a> </div> <p></p> </div> <p></p ></span> </div> <p></p> </div> </div> </div> </section> </div></div> </div> </div> </header> <a id='back_to_top' href='#'> <span class="fa-stack"> <i class="fa fa-arrow-up" style=""></i> </span> </a> <div class="content "> <div class="content_inner "> <div class="title_outer title_without_animation with_image" data-height="217"> <div class="title title_size_small position_left " style="height:217px;background-color:#F6F6F6;"> <div class="image responsive"><img itemprop="image" src="/wp-content/uploads/2017/03/Capella_header_v3.jpg" alt=" " /> </div> </div> </div> <div class="container"> <div class="container_inner default_template_holder" > <div class="vc_row wpb_row section vc_row-fluid grid_section" style='background-color:#ffffff; border-bottom: 1px solid #ffffff; text-align:center;'><div class=" section_inner clearfix"><div class='section_inner_margin clearfix'><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row section vc_row-fluid vc_inner up_block white_block intro" style=' padding-top:50px; text-align:center;'><div class=" full_section_inner clearfix"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element "> <div class="wpb_wrapper"> <h2 class="section-heading" style="text-align: center;"><strong>Capella</strong></h2> </div> </div> <div class="wpb_text_column wpb_content_element text"> <div class="wpb_wrapper"> <h4 style="text-align: center;">Capella—the Online Voice of Progress in RNAi</h4> <p class="intro_custom_subtitle" style="text-align: center;">Welcome to Capella, Alnylam’s destination for updates on our work translating the breakthrough discovery of RNA interference (RNAi) into an innovative new class of medicines. We’ve been pioneering RNAi therapeutics since 2002 and are excited to share our ongoing scientific progress.</p> </div> </div> </div></div></div></div></div></div></div></div></div></div></div> <div class="blog_holder blog_small_image"> <article id="post-26619" class="post-26619 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/11/18/aha-2024" title="New Data Presented in ATTR Amyloidosis and Hypertension at the American Heart Association (AHA) Scientific Sessions 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">18 Nov, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/11/18/aha-2024" title="New Data Presented in ATTR Amyloidosis and Hypertension at the American Heart Association (AHA) Scientific Sessions 2024">New Data Presented in ATTR Amyloidosis and Hypertension at the American Heart Association (AHA) Scientific Sessions 2024</a></h2> <div class="post_info"> <span class="time">Posted at 13:09h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>The following studies were presented at the American Heart Association (AHA) Scientific Sessions 2024: a new analysis of the Phase 3 HELIOS-B study of vutrisiran, an investigational RNAi therapeutic for the treatment of ATTR cardiomyopathy, and a new analysis of the Phase 2 KARDIA-1 study of zilebesiran, an investigational RNAi therapeutic for the treatment of hypertension.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/11/Impact-of-Vutrisiran-on-Outpatient-Worsening-Heart-Failure-in-Patients-with-Transthyretin-Amyloidosis-with-Cardiomyopathy-in-the-HELIOS-B-Trial.pdf" target="_blank" rel="noopener">Fontana, <em>et al</em>. “Impact of Vutrisiran on Outpatient Worsening Heart Failure in Patients with Transthyretin Amyloidosis with Cardiomyopathy in the HELIOS-B Trial”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/11/Impact-of-Long-Term-Blood-Pressure-Variability-on-Adverse-Cardiovascular-Outcomes-in-High-and-Low-Risk-Populations.pdf" target="_blank" rel="noopener">Krohn, <em>et al</em>. “Impact of Long-Term Blood Pressure Variability on Adverse Cardiovascular Outcomes in High- and Low-Risk Populations”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/11/Home-Blood-Pressure-Reductions-with-Zilebesiran-in-Patients-with-Mild-to-Moderate-Hypertension-are-Consistent-with.pdf" target="_blank" rel="noopener">Zappe, <em>et al</em>. “Home Blood Pressure Reductions with Zilebesiran in Patients with Mild-to-Moderate Hypertension Are Consistent with Ambulatory and Office Blood Pressure Reductions in the KARDIA-1 Study”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/11/18/aha-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26610" class="post-26610 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/11/17/nucre-aha-2024" title="New Results from an Interim Phase 1 Study Evaluating Nucresiran (ALN-TTRsc04) Presented at the American Heart Association (AHA) Scientific Sessions 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">17 Nov, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/11/17/nucre-aha-2024" title="New Results from an Interim Phase 1 Study Evaluating Nucresiran (ALN-TTRsc04) Presented at the American Heart Association (AHA) Scientific Sessions 2024">New Results from an Interim Phase 1 Study Evaluating Nucresiran (ALN-TTRsc04) Presented at the American Heart Association (AHA) Scientific Sessions 2024</a></h2> <div class="post_info"> <span class="time">Posted at 10:36h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>Results from the interim Phase 1 study of nucresiran (ALN-TTRsc04), an investigational next-generation RNAi therapeutic for the treatment of transthyretin amyloidosis, were presented at the American Heart Association (AHA) Scientific Sessions 2024.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/11/A-Phase-1-Single-Ascending-Dose-Studyto-Evaluate-ALN-TTRsc04-a-Next-GenerationRNA-Interference-Therapeutic-in-Healthy-Participants-for-Potential-Treatment-of-Transthyretin-Amyloidosis-1.pdf" target="_blank" rel="noopener">Murad <em>et al</em>. “A Phase 1, Single Ascending Dose Study to Evaluate ALN-TTRsc04, a Next-Generation RNA Interference Therapeutic, in Healthy Participants for Potential Treatment of Transthyretin Amyloidosis”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/11/17/nucre-aha-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26607" class="post-26607 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/11/09/htt-hsg-2024" title="Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the Annual Meeting of the Huntington Study Group (HSG)"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">09 Nov, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/11/09/htt-hsg-2024" title="Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the Annual Meeting of the Huntington Study Group (HSG)">Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the Annual Meeting of the Huntington Study Group (HSG)</a></h2> <div class="post_info"> <span class="time">Posted at 15:12h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>The design of a Phase 1 study of ALN-HTT02—an investigational RNAi therapeutic targeting huntingtin (HTT) for Huntington’s disease—was presented at the 31st Annual Meeting of the Huntington Study Group (HSG) in Cincinnati, Ohio.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/11/Innovators-Forum_110724_Kevin-Sloan-HSG2024_uploaded.pdf" target="_blank" rel="noopener">Sloan, <em>et al</em>. “ALN-HTT02, a Novel C16-siRNA Conjugate for HTT-lowering in the CNS”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/11/09/htt-hsg-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26600" class="post-26600 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/10/31/mivelsiran-ctad-2024" title="Overview of cAPPricorn-1 Trial of Mivelsiran Presented at CTAD Conference 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">31 Oct, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/10/31/mivelsiran-ctad-2024" title="Overview of cAPPricorn-1 Trial of Mivelsiran Presented at CTAD Conference 2024">Overview of cAPPricorn-1 Trial of Mivelsiran Presented at CTAD Conference 2024</a></h2> <div class="post_info"> <span class="time">Posted at 09:41h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>Trial design and rationale for the global Phase 2 cAPPricorn-1 study of mivelsiran (ALN-APP) in patients with cerebral amyloid angiopathy (CAA), were presented at the Clinical Trials on Alzheimer’s Disease (CTAD) Conference 2024.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/10/cAPPricorn-1-Study-Design_CTAD-2024-Presentation_FINAL_v2.pdf" target="_blank" rel="noopener">Lee, <em>et al</em>. “Design and Rationale of cAPPricorn-1, A Phase 2 Study of Mivelsiran in Patients with Cerebral Amyloid Angiopathy”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/10/31/mivelsiran-ctad-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26534" class="post-26534 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/10/09/alnylam-ttr-investor-day-2024" title="Alnylam TTR Investor Day 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">09 Oct, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/10/09/alnylam-ttr-investor-day-2024" title="Alnylam TTR Investor Day 2024">Alnylam TTR Investor Day 2024</a></h2> <div class="post_info"> <span class="time">Posted at 08:06h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>On October 9, 2024, we hosted a TTR Investor Day to discuss Alnylam’s potential for market leadership in ATTR amyloidosis. The event included presentations from Alnylam’s senior commercial leaders, as well as a leading expert in ATTR amyloidosis.</p> <p>To view the webcast, click <a href="https://app.webinar.net/63YDow20lr8" target="_blank" rel="noopener"><strong>here</strong></a><br /> To view the presentation, click <strong><a href="https://capella.alnylam.com/wp-content/uploads/2024/10/ALNY-TTR-Investor-Day_vFinal.pdf" target="_blank" rel="noopener">here</a></strong></p> <p> <a href="https://capella.alnylam.com/2024/10/09/alnylam-ttr-investor-day-2024#more-26534" class="more-link"><span aria-label="Continue reading Alnylam TTR Investor Day 2024">(more…)</span></a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/10/09/alnylam-ttr-investor-day-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26548" class="post-26548 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/29/vutri-hfsa-2024" title="Additional Results from the HELIOS-B Phase 3 study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Presented at the Heart Failure Society of America Annual Scientific Meeting 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">29 Sep, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/09/29/vutri-hfsa-2024" title="Additional Results from the HELIOS-B Phase 3 study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Presented at the Heart Failure Society of America Annual Scientific Meeting 2024">Additional Results from the HELIOS-B Phase 3 study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Presented at the Heart Failure Society of America Annual Scientific Meeting 2024</a></h2> <div class="post_info"> <span class="time">Posted at 09:17h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>Additional results from the HELIOS-B Phase 3 study of vutrisiran, an RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM), were presented in the Late Breaking Clinical Research Session 1 at the Heart Failure Society of America Annual Scientific Meeting 2024.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Jering_HB-Echo-HFSA_Oral_DV1044_FINAL.pdf" target="_blank" rel="noopener">Jering, <em>et al</em>. “Effects of Vutrisiran on Echocardiographic Cardiac Structure and Function: The HELIOS-B Trial”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Maurer_HB-HFSA-Biomarkers-w-outcomes_16Nov24-FINAL-w-update.pdf" target="_blank" rel="noopener">Maurer, <em>et al</em>. “Exploratory Biomarker Analyses from HELIOS-B, a Phase 3 Study of Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/29/vutri-hfsa-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26530" class="post-26530 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/24/givo-icpp-2024" title="New Results for Acute Hepatic Porphyria (AHP) Program Presented at ICPP 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">24 Sep, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/09/24/givo-icpp-2024" title="New Results for Acute Hepatic Porphyria (AHP) Program Presented at ICPP 2024">New Results for Acute Hepatic Porphyria (AHP) Program Presented at ICPP 2024</a></h2> <div class="post_info"> <span class="time">Posted at 09:39h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>New results from a post hoc subgroup analysis of the ENVISION Phase 3 study evaluating long-term outcomes in patients with acute hepatic porphyria (AHP) who were not attack-free after the first six months of GIVLAARI<sup>®</sup> (givosiran) treatment were presented at The International Congress of Porphyrins and Porphyrias (ICPP 2024). Additional data presented at ICPP 2024 included demographic and clinical characteristics of patients with AHP enrolled in ELEVATE, an international, prospective, observational registry.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Ventura-et-al.pdf" target="_blank" rel="noopener">Ventura, <em>et al</em>. “Long-term clinical outcomes of patients with acute hepatic porphyria who were not attack-free after 6 months of givosiran treatment: a subgroup analysis of the phase 3 ENVISION study”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Sardh-et-al.pdf" target="_blank" rel="noopener">Sardh, <em>et al</em>. “Patient demographics and clinical characteristics at enrolment in ELEVATE, an international registry of acute hepatic porphyria”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/24/givo-icpp-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26525" class="post-26525 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024" title="Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">13 Sep, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024" title="Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress">Design of Phase 1 Study of ALN-HTT02 in Adult Patients with Huntington’s Disease Presented at the EHDN & Enroll-HD 2024 Congress</a></h2> <div class="post_info"> <span class="time">Posted at 08:50h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>The design of a Phase 1 study of ALN-HTT02—an investigational RNAi therapeutic targeting huntingtin (HTT) for Huntington’s disease—was presented at the EHDN & Enroll-HD 2024 Congress in Strasbourg, France. Nonclinical data supporting the tolerability of deep and sustained HTT-lowering in wild-type nonhuman primates after single and repeated intrathecal administration of ALN-HTT02—which employs Alnylam’s C16-siRNA CNS delivery platform—were also shared.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Sloan_ALN-HTT02-Program-Overview_EHDN-Presentation_FINAL.pdf" target="_blank" rel="noopener">Sloan, <em>et al</em>. “ALN-HTT02, a Novel C16-siRNA Conjugate for HTT-lowering in the CNS”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/2024-EHDN-Poster-HTT_WLC_final.pdf" target="_blank" rel="noopener">Cantley, <em>et al</em>. “Tolerability of HTT-Lowering: Lessons Learned from Nonhuman Primates”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/13/htt02-ehdn-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26517" class="post-26517 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/01/zilebe-pati-esc-2024" title="New Data from the KARDIA-2 Phase 2 Study of Zilebesiran and the APOLLO-B Phase 3 and APOLLO-OLE Studies of Patisiran Presented at the European Society of Cardiology (ESC) Congress 2024"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">01 Sep, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/09/01/zilebe-pati-esc-2024" title="New Data from the KARDIA-2 Phase 2 Study of Zilebesiran and the APOLLO-B Phase 3 and APOLLO-OLE Studies of Patisiran Presented at the European Society of Cardiology (ESC) Congress 2024">New Data from the KARDIA-2 Phase 2 Study of Zilebesiran and the APOLLO-B Phase 3 and APOLLO-OLE Studies of Patisiran Presented at the European Society of Cardiology (ESC) Congress 2024</a></h2> <div class="post_info"> <span class="time">Posted at 12:42h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>Findings from a subgroup analysis of the KARDIA-2 Phase 2 study of zilebesiran, in development for the treatment of hypertension, and new data from post-hoc analyses of the APOLLO-B Phase 3 and APOLLO-OLE studies of patisiran in patients with ATTR amyloidosis with cardiomyopathy (ATTR-CM) were presented at the European Society of Cardiology Congress (ESC) 2024.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Subgroup-Results-from-KARDIA-2_-Impact-of-Demographic-and-Baseline-Disease-Characteristics-on-Zilebesiran-Response-in-Patients-with-Hypertension-Uncontrolled-by-a-Standard-Oral-Antihypertensive-2.pdf" target="_blank" rel="noopener">Saxena, <em>et al</em>. “Subgroup Results from KARDIA-2: Impact of Demographic and Baseline Disease Characteristics on Zilebesiran Response in Patients with Hypertension Uncontrolled by a Standard Oral Antihypertensive”</a></p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/09/Long-Term-Effects-of-Patisiran-on-Survival-and-Cardiac-Parameters-in-Patients-with-Transthyretin-Mediated-Cardiac-Amyloidosis_-Post-Hoc-Analysis-of-APOLLO-B-and-Cardiac-Subpopulation-of-APOLLO-OLE.pdf" target="_blank" rel="noopener">Lairez, <em>et al</em>. “Long-term Effects of Patisiran on Survival and Cardiac Parameters in Patients with Transthyretin-Mediated Cardiac Amyloidosis: Post-hoc Analyses of APOLLO-B and Cardiac Subpopulation of APOLLO-OLE”</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/09/01/zilebe-pati-esc-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <article id="post-26513" class="post-26513 post type-post status-publish format-standard hentry category-capella"> <div class="post_content_holder std"> <?php// if ( has_post_thumbnail() ) { ?> <div class="post_image standard"> <a itemprop="url" href="https://capella.alnylam.com/2024/08/30/vutri-esc-2024" title="Detailed Results from the HELIOS-B Phase 3 study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Presented at the ESC Congress 2024 and Published in The New England Journal of Medicine"> <img src="/wp-content/uploads/2017/03/default_blog_image.jpg" /> </a> </div> <?php// } ?> <div class="post_text"> <div class="post_text_inner test"> <h2 itemprop="name" class="entry_title"><span itemprop="dateCreated" class="date entry_date updated">30 Aug, 2024<meta itemprop="interactionCount" content="UserComments: 0"/></span> <a itemprop="url" href="https://capella.alnylam.com/2024/08/30/vutri-esc-2024" title="Detailed Results from the HELIOS-B Phase 3 study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Presented at the ESC Congress 2024 and Published in The New England Journal of Medicine">Detailed Results from the HELIOS-B Phase 3 study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Presented at the ESC Congress 2024 and Published in The New England Journal of Medicine</a></h2> <div class="post_info"> <span class="time">Posted at 06:00h</span> in <a href="https://capella.alnylam.com/category/capella" rel="category tag">Capella</a> </div> <p>Detailed results from the Phase 3 HELIOS-B study of vutrisiran, an RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM), were presented in a Hot Line session at the European Society of Cardiology Congress (ESC) 2024 and simultaneously published in <em>The New England Journal of Medicine</em>.</p> <p><a href="https://capella.alnylam.com/wp-content/uploads/2024/08/Primary-Results-from-HELIOS-B-a-Phase-3-Study-of-Vutrisiran-in-Patients-with-Transthyretin-Amyloidosis-with-Cardiomyopathy.pdf" target="_blank" rel="noopener">Fontana, <em>et al</em>. “Primary Results from HELIOS-B, a Phase 3 Study of Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy”</a></p> <p><a href="https://www.nejm.org/stoken/default+domain/REPRINTS_36492/full?redirectUri=/doi/full/10.1056/NEJMoa2409134" target="_blank" rel="noopener">Read the manuscript</a></p> <div class="post_more"> <a itemprop="url" href="https://capella.alnylam.com/2024/08/30/vutri-esc-2024" class="qbutton small">Read More</a> </div> </div> </div> </div> </article> <div class='pagination'><ul><li class='prev'><a itemprop='url' 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