Vaccine Safety and Immunogenicity in Pediatric Patients with

<!DOCTYPE html> <html lang="hi"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Vaccine Safety and Immunogenicity in Pediatric Patients with | 121597</title> <meta name="keywords" content="Mireia Lopez Corbeto*, Irene Torrecilla Martínez, Estefanía Moreno Ruzafa, Laia Martínez Mitjana, José Ángel Rodrigo Pendás, Xavier Martínez Gómez, "/> <meta name="description" content="Immune-mediated Pediatric Rheumatic Diseases (IMPRD) is potentially serious diseases that can lead to a significant decrease in the child's quality of ..121597"/> <meta name="citation_publisher" content="वॉल्श मेडिकल मीडिया" /> <meta name="citation_journal_title" content="टीके और टीकाकरण जर्नल"> <meta name="citation_title" content="Vaccine Safety and Immunogenicity in Pediatric Patients with Immune-mediated Inflammatory Diseases"> <meta name="citation_author" content="Mireia Lopez Corbeto" /> <meta name="citation_author" content="Irene Torrecilla Martínez" /> <meta name="citation_author" content="Estefanía Moreno Ruzafa" /> <meta name="citation_author" content="Laia Martínez Mitjana" /> <meta name="citation_author" content="José Ángel Rodrigo Pendás" /> <meta name="citation_author" content="Xavier Martínez Gómez" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="14"> <meta name="citation_issue" content="7"> <meta name="citation_abstract" content="Immune-mediated Pediatric Rheumatic Diseases (IMPRD) is potentially serious diseases that can lead to a significant decrease in the child's quality of life. The use of immunosuppressive therapies necessary in IMPRD may contribute to an increased risk of infections. The objective is to describe the prevalence of susceptibility to vaccine-preventable diseases and the immunogenicity and safety of vaccines in patients with IMPRD. A prospective cohort study included 36 pediatric patients with an IMPRD who visited a large tertiary hospital. Pre-vaccination serological tests were performed, and a vaccination plan was developed for each patient. Blood samples were collected for study of the post-vaccination seroprotection when needed. Follow-up was performed to analyze the safety of the vaccines: local and systemic reactions were evaluated during 28 days after vaccination, while detection of flares was reviewed until 3 months after. The vaccination schedule was not completed in 6 patients (16.7%). A total of 146 vaccines were administered with a median of 2 vaccines per child and visit. Overall seroprotection rates at the inclusion were higher than 80%, being the highest proportion in varicella (94.5% (95CI%: 81.9-98.5)) and the lowest in hepatitis B (47.2% (95% CI: 32.0-63.0)). Seroprotection rate after vaccination was higher than 90% for all vaccines. There were 15 local and 1 systemic adverse events after vaccination. No flares were observed. Vaccination is safe and overall immunogenic in this population. We recommend assessing vaccination requirements in IMPRD as soon as their diagnosis is made."> <meta name="citation_abstract_html_url" content="https://hindi.walshmedicalmedia.com/abstract/vaccine-safety-and-immunogenicity-in-pediatric-patients-with-immunemediated-inflammatory-diseases-121597.html"> <meta itemprop="name" content="वॉल्श मेडिकल मीडिया" /> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="hi"> <meta name="google-site-verification" content="YjHsSGOfJVjTiVTf6S4LqoaspPRh3ErDWaq1RaXtrAY" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" href="https://hindi.walshmedicalmedia.com/abstract/vaccine-safety-and-immunogenicity-in-pediatric-patients-with-immunemediated-inflammatory-diseases-121597.html"> <link rel="alternate" 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Patients with Immune-mediated Inflammatory Diseases</h3> <p> <i class="fas fa-user"></i> Mireia Lopez Corbeto*, Irene Torrecilla Martínez, Estefanía Moreno Ruzafa, Laia Martínez Mitjana, José Ángel Rodrigo Pendás, Xavier Martínez Gómez </p> <p><p>Immune-mediated Pediatric Rheumatic Diseases (IMPRD) is potentially serious diseases that can lead to a significant decrease in the child's quality of life. The use of immunosuppressive therapies necessary in IMPRD may contribute to an increased risk of infections. The objective is to describe the prevalence of susceptibility to vaccine-preventable diseases and the immunogenicity and safety of vaccines in patients with IMPRD. A prospective cohort study included 36 pediatric patients with an IMPRD who visited a large tertiary hospital. Pre-vaccination serological tests were performed, and a vaccination plan was developed for each patient. Blood samples were collected for study of the post-vaccination seroprotection when needed. Follow-up was performed to analyze the safety of the vaccines: local and systemic reactions were evaluated during 28 days after vaccination, while detection of flares was reviewed until 3 months after. The vaccination schedule was not completed in 6 patients (16.7%). A total of 146 vaccines were administered with a median of 2 vaccines per child and visit. Overall seroprotection rates at the inclusion were higher than 80%, being the highest proportion in varicella (94.5% (95CI%: 81.9-98.5)) and the lowest in hepatitis B (47.2% (95% CI: 32.0-63.0)). Seroprotection rate after vaccination was higher than 90% for all vaccines. There were 15 local and 1 systemic adverse events after vaccination. No flares were observed. Vaccination is safe and overall immunogenic in this population. We recommend assessing vaccination requirements in IMPRD as soon as their diagnosis is made.</p></p> <div class="alert alert-info text-left"><b>अस्वीकृति:</b> इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है। </div> <div class="nav social-icons align-items-center"> <p class="m-0">इस लेख का हिस्सा:</p> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" rel="noopener" href="https://www.facebook.com/sharer.php?u=https://hindi.walshmedicalmedia.com/abstract/vaccine-safety-and-immunogenicity-in-pediatric-patients-with-immunemediated-inflammatory-diseases-121597.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" rel="noopener" href="https://twitter.com/share?url=https://hindi.walshmedicalmedia.com/abstract/vaccine-safety-and-immunogenicity-in-pediatric-patients-with-immunemediated-inflammatory-diseases-121597.html"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" rel="noopener" href="https://www.linkedin.com/shareArticle?mini=true&url=https://hindi.walshmedicalmedia.com/abstract/vaccine-safety-and-immunogenicity-in-pediatric-patients-with-immunemediated-inflammatory-diseases-121597.html"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" rel="noopener" href="https://plus.google.com/share?url=https://hindi.walshmedicalmedia.com/abstract/vaccine-safety-and-immunogenicity-in-pediatric-patients-with-immunemediated-inflammatory-diseases-121597.html"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section>   <div class="whatup"> <ul> <li><a href="tel:+44 1692310016">+44 1692310016 <i class="fab fa-whatsapp" aria-hidden="true"></i></a></li> </ul> </div> <section> <footer> <div class="custom-footer"> <div class="container"> <div class="row"> <div class="col-md-3 md-margin-bottom-40"> <a download="" href="https://hindi.walshmedicalmedia.com/"><img id="logo-footer" src="/assets/images/footer-logo.png" alt="वॉल्श मेडिकल मीडिया" width="220px;"></a> <p>वॉल्श मेडिकल मीडिया (डब्ल्यूएमएम) सहकर्मी-समीक्षित मूल शोध और विश्लेषण प्रस्तुत करता है जो विशेष रूप से सिज़ोफ्रेनिया और संबंधित मनोविकारों के उपचार से संबंधित है और रोगी की देखभाल के लिए सीधे प्रासंगिक है।</p> </div> <div class="col-md-3 md-margin-bottom-40"> <div class="headline"> <h2>उपयोगी कड़ियां</h2> </div> <ul class="list-unstyled link-list"> <li><a href="https://hindi.walshmedicalmedia.com/" title="यहाँ क्लिक करें">घर</a><i class="fa fa-angle-right"></i></li> <li><a href="https://hindi.walshmedicalmedia.com/open-access-journals-list.html" title="यहाँ क्लिक करें">पत्रिकाओं</a><i class="fa fa-angle-right"></i></li> <li><a href="https://hindi.walshmedicalmedia.com/publish-with-us.html" title="यहाँ क्लिक करें">हमारे साथ प्रकाशित करें</a><i class="fa fa-angle-right"></i></li> <li><a href="https://hindi.walshmedicalmedia.com/contact-us.html" title="यहाँ क्लिक करें">संपर्क करें</a><i class="fa fa-angle-right"></i></li> </ul> </div> <div class="col-md-4 map-img md-margin-bottom-40"> <div class="headline"> <h2>संपर्क करें</h2> </div> <h3>पता</h3> <address>कार्यालय 317 बाउंडरी हाउस,<br/> क्रिकेट फ़ील्ड रोड, उक्सब्रिज,<br/> UB8 1QG, लंडन, यूके।<br/> ईमेल: <a href="mailto:manuscripts@walshmedicalmedia.com">manuscripts@walshmedicalmedia.com</a><br/> व्हाट्सएप नंबर: +44 1692310016 </address> </div> <div class="col-md-2 md-margin-bottom-40"> <div class="headline"> <h2>जोड़ना</h2> </div> <ul class="list-unstyled link-list1"> <li><a target="_blank" href="https://www.facebook.com/walshmedicalmedia/" title="यहाँ क्लिक करें"><i class="fab fa-facebook"></i></a></li> <li><i class="fab fa-twitter"></i><a target="_blank" href="https://twitter.com/WalshMedical" title="यहाँ क्लिक करें"></a></li> <li><a target="_blank" href="https://www.instagram.com/walsh.medicalmedia/" title="यहाँ क्लिक करें"><i class="fab fa-instagram"></i></a></li> <li><a target="_blank" href="https://www.linkedin.com/company/walsh-medical-media/" title="यहाँ क्लिक करें"><i class="fab fa-linkedin" aria-hidden="true"></i></a></li> </ul> </div> </div> </div> </div> <div class="copyright"> <div class="container"> <div class="row"> <div class="col-md-12"> <p> कॉपीराइट © 2024 <a href="https://hindi.walshmedicalmedia.com/" title="यहाँ क्लिक करें">वॉल्श मेडिकल मीडिया</a> </p> </div> </div> </div> </div> </footer> <a download="" id="back-to-top" href="#" class="btn btn-dark btn-lg back-to-top text-white" role="button"> <i class="fa fa-chevron-up"></i> </a> </section> <script type="text/javascript"> $(document).ready(function() { $(window).scroll(function() { if ($(this).scrollTop() > 100) { $("#back-to-top").fadeIn(); 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Vaccine Safety and Immunogenicity in Pediatric Patients with | 121597