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<!DOCTYPE html> <html lang="ko"> <head> <title>OASIS Repository@POSTECHLIBRARY: A brief history of nearly EV-erything - The rise and rise of extracellular vesicles</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="Generator" content="DSpace 5.5" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="description" content="Postech OASIS Repository" /> <meta name="keywords" content="오아시스,레포지토리,리포지터리,저장소,포스텍,박태준학술정보관,포항공과대학교,포항공대,POSTECH,Pohang University of Science and Technology,도서관,IR,연구업적,학술실적,연구성과,dspace" /> <link rel="shortcut icon" href="/favicon.ico" type="image/x-icon"/> <link rel="search" type="application/opensearchdescription+xml" href="/open-search/description.xml" title="DSpace" /> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <link rel="schema.OAK" href="http://www.oak.go.kr/terms/" /> <meta name="OAK.author" content="Couch, Yvonne" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Buzas, Edit I." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Vizio, Dolores Di" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Gho, Yong Song" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Harrison, Paul" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Hill, Andrew F." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Lotvall, Jan" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Raposo, Graca" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Stahl, Philip D." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Thery, Clotilde" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Witwer, Kenneth W." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Carter, David R. F." scheme="OAK.AUTHOR" /> <meta name="DCTERMS.dateAccepted" content="2022-06-23T02:21:06Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.available" content="2022-06-23T02:21:06Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.created" content="2022-01-13" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.issued" content="2021-12" scheme="DCTERMS.W3CDTF" /> <meta name="OAK.identifier.issn" content="2001-3078" scheme="OAK.ISSN" /> <meta name="DC.identifier" content="https://oasis.postech.ac.kr/handle/2014.oak/113039" scheme="DCTERMS.URI" /> <meta name="DCTERMS.abstract" content="Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell-to-cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to take stock and look back on how the field started, and has since exploded into its current state. Here we review the early experiments, summarise key findings that have propelled the field, describe the growth of an organised EV community, discuss the current state of the field, and identify key challenges that need to be addressed." /> <meta name="DC.language" content="English" /> <meta name="DC.publisher" content="WILEY" /> <meta name="DC.relation" content="JOURNAL OF EXTRACELLULAR VESICLES" /> <meta name="DC.title" content="A brief history of nearly EV-erything - The rise and rise of extracellular vesicles" /> <meta name="DC.type" content="Article" /> <meta name="DC.identifier" content="10.1002/jev2.12144" /> <meta name="DC.identifier" content="48442" /> <meta name="DC.type" content="ART" /> <meta name="DC.identifier" content="JOURNAL OF EXTRACELLULAR VESICLES, v.10, no.14" /> <meta name="DC.identifier" content="000731111900001" /> <meta name="OAK.relation.issue" content="14" scheme="OAK.ISSUE" /> <meta name="OAK.relation.journal" content="JOURNAL OF EXTRACELLULAR VESICLES" scheme="OAK.JOURNAL" /> <meta name="OAK.relation.volume" content="10" scheme="OAK.VOLUME" /> <meta name="DC.contributor" content="Gho, Yong Song" /> <meta name="DC.identifier" content="2-s2.0-85121715808" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="N" /> <meta name="DC.type" content="Review" /> <meta name="DC.subject" content="CELL-DERIVED EXOSOMES" /> <meta name="DC.subject" content="VIRUS-LIKE PARTICLES" /> <meta name="DC.subject" content="TRYPSIN-LIKE-ENZYME" /> <meta name="DC.subject" content="TRANSFERRIN RECEPTOR" /> <meta name="DC.subject" content="MEMBRANE-VESICLES" /> <meta name="DC.subject" content="PLATELET MICROPARTICLES" /> <meta name="DC.subject" content="RETICULOCYTE MATURATION" /> <meta name="DC.subject" content="MULTIVESICULAR BODY" /> <meta name="DC.subject" content="PROTEOMIC ANALYSIS" /> <meta name="DC.subject" content="HUMAN NEUTROPHILS" /> <meta name="DC.subject" content="microvesicle" /> <meta name="DC.subject" content="ectosome" /> <meta name="DC.subject" content="exosome" /> <meta name="DC.subject" content="extracellular vesicle" /> <meta name="DC.subject" content="microparticle" /> <meta name="DC.relation" content="Cell Biology" /> <meta name="DC.description" content="scie" /> <meta name="DC.description" content="scopus" /> <meta name="citation_keywords" content="Article" /> <meta name="citation_title" content="A brief history of nearly EV-erything - The rise and rise of extracellular vesicles" /> <meta name="citation_issn" content="2001-3078" /> <meta name="citation_publisher" content="WILEY" /> <meta name="citation_author" content="Couch, Yvonne" /> <meta name="citation_author" content="Buzas, Edit I." /> <meta name="citation_author" content="Vizio, Dolores Di" /> <meta name="citation_author" content="Gho, Yong Song" /> <meta name="citation_author" content="Harrison, Paul" /> <meta name="citation_author" content="Hill, Andrew F." /> <meta name="citation_author" content="Lotvall, Jan" /> <meta name="citation_author" content="Raposo, Graca" /> <meta name="citation_author" content="Stahl, Philip D." /> <meta name="citation_author" content="Thery, Clotilde" /> <meta name="citation_author" content="Witwer, Kenneth W." /> <meta name="citation_author" content="Carter, David R. 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F.</a></dd></dl> <dl><dt>Date Issued</dt><dd>2021-12 </dd></dl> <dl><dt>Publisher</dt><dd>WILEY</dd></dl> <dl><dt>Abstract</dt><dd>Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell-to-cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to take stock and look back on how the field started, and has since exploded into its current state. Here we review the early experiments, summarise key findings that have propelled the field, describe the growth of an organised EV community, discuss the current state of the field, and identify key challenges that need to be addressed.</dd></dl> <dl><dt>URI</dt><dd><a href="https://oasis.postech.ac.kr/handle/2014.oak/113039" class="link_type">https://oasis.postech.ac.kr/handle/2014.oak/113039</a></dd></dl> <dl><dt>DOI</dt><dd><a href="http://dx.doi.org/10.1002/jev2.12144">10.1002/jev2.12144</a></dd></dl> <dl><dt>ISSN</dt><dd>2001-3078</dd></dl> <dl><dt>Article Type</dt><dd>Article</dd></dl> <dl><dt>Citation</dt><dd>JOURNAL OF EXTRACELLULAR VESICLES, vol. 10, no. 14, 2021-12</dd></dl> <dl class="file_item_dl"><dt>Files in This Item:</dt> <dd class="file_download">There are no files associated with this item.</dd> </dl> </div> <div class="record_bt_box"> <a href="/handle/2014.oak/113039?mode=full">Show full item record</a> </div> <div class="al_right"> </div> <div class="sns_wrap"> <div class="sns_box"> <p class="qr_box"><img src="https://api.qrserver.com/v1/create-qr-code/?size=66x66&data=https://oasis.postech.ac.kr/handle/2014.oak/113039" alt="qr_code"></p> <div class="sns_inner"> <ul> <li> <p><a href="http://www.mendeley.com/import/?url=https://oasis.postech.ac.kr/handle/2014.oak/113039" target="_blank"><img src="/image/common/mendeley_icon.gif" alt="mendeley" /></a></p> <p class="twitter_box"> <a href="https://twitter.com/share" class="tweet_bt twitter-share-button" data-lang="en" data-size="large" data-dnt="true">트윗하기</a> <script> !function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (!d.getElementById(id)) { js = d.createElement(s); js.id = id; js.src = "//platform.twitter.com/widgets.js"; fjs.parentNode.insertBefore(js, fjs); } }(document, "script", "twitter-wjs"); </script> </p> </li> <li class="facebook_li"> <span id="fb-root"></span> <script> (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/ko_KR/all.js#xfbml=1"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); </script> <span class="fb-like" data-send="true" data-layout="standard" data-width="450" data-show-faces="false" data-font="verdana"></span> </li> </ul> </div> </div> <p class="sns_text"> <span> Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.</span> </p> </div> </div> </div>  <div class="sub_right_box"> <div class="w_cc"> <h4 class="widget_title">Communities & Collection</h4> <ul> <li><a href="/handle/2014.oak/398" class="cc_item">General Graduate School of Life Science (일반대학원 생명과학과)</a> <ul> <li><a href="/handle/2014.oak/399">1. 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