Home - Calico

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class="content-area"> <main id="main" class="site-main"> <article id="post-10" class="post-10 page type-page status-publish hentry"> <div class="entry-content"> <div class="experience home_hero" id="home_hero_block_b6f129d06869c2cb0d1831869a827c81"> <div class="temp_slide"> <div class="title">We are tackling aging…</div> <div class="subtitle"></div> </div> <div class="temp_slide"> <div class="title">One of life’s greatest mysteries</div> <div class="subtitle"></div> </div> <div class="temp_slide"> <div class="title">What is the underlying biology that determines how fast an organism ages?</div> <div class="subtitle"></div> </div> <div class="temp_slide"> <div class="title">What if we could better understand how we age?</div> <div class="subtitle"></div> </div> <div class="temp_slide"> <div class="title">How can we help people live longer, healthier lives?</div> <div class="subtitle"></div> </div> <div class="temp_slide"> <div class="title">Challenging questions like these brought us to science.</div> <div class="subtitle">And today, they are helping us develop potential new interventions.</div> </div> <div class="temp_slide skip"> <div class="title">It’s no secret. Life at Calico is about science. And science is our life.</div> <div class="subtitle"></div> </div> </div> <section id="page_section_block_f1c356758a3ca1da9ad4201ca8ff1ee0" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_color " style="--background-color:#f1efeb;"> <div class="acf-innerblocks-container"> <div class="mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default cl_slider container from-bottom__0" id="card_link_sliderblock_cd65ec55ba1ccfb2942650a3a98c3371" style=""> <div class="cl_slider__inner"> <div class="cl_slider__slide type-image"> <a href="https://www.nature.com/articles/s41586-024-08026-3" class="no_underline" target="_blank"> <div class="cl_slider__main cl_slider__slide_bg block_background background_type_image block_background__media" style="--bg-position-x-dt:left;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;"> <figure class="cl_slider__slide_bg block_background background_type_image block_background__media " style="--bg-position-x-dt:left;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center; "><img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-2000x1128.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-2000x1128.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-1200x677.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-768x433.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-1536x866.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-2048x1155.jpg 2048w" data-sizes="(max-width:2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000/1128;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-2000x1128.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-2000x1128.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-1200x677.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-768x433.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-1536x866.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2024/10/Caloric-paper-slider-2-2048x1155.jpg 2048w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></figure> </div> <div class="cl_slider__secondary"> <div class="t-quote"> <p>Research collaboration sheds new light on the relationship between genetics, diet, health and longevity.</p> </div> </div> </a> </div> <div class="cl_slider__slide type-image"> <a href="https://www.calicolabs.com/press/calico-life-sciences-announces-that-fosigotifator-abbv-cls-7262-for-vanishing-white-matter-disease-has-been-selected-for-the-fda-start-pilot-program/" class="no_underline"> <div class="cl_slider__main cl_slider__slide_bg block_background background_type_image block_background__media" style="--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;"> <figure class="cl_slider__slide_bg block_background background_type_image block_background__media " style="--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center; "><img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-2000x907.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-2000x907.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-1200x544.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-768x348.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-1536x697.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-2048x929.jpg 2048w" data-sizes="(max-width:2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000/907;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-2000x907.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-2000x907.jpg 2000w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-1200x544.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-768x348.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-1536x697.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2024/03/Asset-1wordmark-2048x929.jpg 2048w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></figure> </div> <div class="cl_slider__secondary"> <div class="t-quote"> <p>Calico Life Sciences Announces that Fosigotifator (ABBV-CLS-7262) for Vanishing White Matter Disease has been Selected for the FDA START Pilot Program</p> </div> </div> </a> </div> <div class="cl_slider__slide type-image"> <a href="https://www.calicolabs.com/press/calico-and-broad-institute-extend-collaboration-adding-focus-on-age-related-neurodegeneration/" class="no_underline"> <div class="cl_slider__main cl_slider__slide_bg block_background background_type_image block_background__media" style="--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;"> <figure class="cl_slider__slide_bg block_background background_type_image block_background__media " style="--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center; "><img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857.jpg 1350w, https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857-1200x850.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857-768x544.jpg 768w" data-sizes="(max-width:2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 1350px; --smush-placeholder-aspect-ratio: 1350/956;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857.jpg 1350w, https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857-1200x850.jpg 1200w, https://www.calicolabs.com/wp-content/uploads/2024/05/broad-generic-2-e1715202554857-768x544.jpg 768w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></figure> </div> <div class="cl_slider__secondary"> <div class="t-quote"> <p>Calico and Broad Institute Extend Collaboration Adding Focus on Age-Related Neurodegeneration</p> </div> </div> </a> </div> <div class="cl_slider__slide type-image"> <a href="https://www.calicolabs.com/press/calico-appoints-michael-lenardo-m-d-as-chief-scientific-officer/" class="no_underline"> <div class="cl_slider__main cl_slider__slide_bg block_background background_type_image block_background__media" style="--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;"> <figure class="cl_slider__slide_bg block_background background_type_image block_background__media " style="--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center; "><img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-2000x1128.png" data-srcset="https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-2000x1128.png 2000w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-1200x677.png 1200w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-768x433.png 768w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-1536x866.png 1536w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-2048x1155.png 2048w" data-sizes="(max-width:2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000/1128;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-2000x1128.png" srcset="https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-2000x1128.png 2000w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-1200x677.png 1200w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-768x433.png 768w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-1536x866.png 1536w, https://www.calicolabs.com/wp-content/uploads/2024/09/Dr.-Lenardo-homepage-gfx-2-1-2048x1155.png 2048w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></figure> </div> <div class="cl_slider__secondary"> <div class="t-quote"> <p>Michael Lenardo, M.D., joins Calico Life Sciences as Chief Scientific Officer</p> </div> </div> </a> </div> <blockquote class="cl_slider__slide type-quote"> <a href="https://www.calicolabs.com/people/arthur-d-levinson/" class="no_underline"> <div class="cl_slider__main" style=""> <div class="h4"> "History is replete with examples of breakthroughs occurring when curious people are given the freedom to operate and create when embedded in a nurturing culture and a ‘healthy’ questioning environment." </div> </div> <div class="cl_slider__secondary"> <cite class="cl_slider__cite"> <figure class="cl_slider__portrait"> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/smush-webp/2021/06/Art_4--e1623433634553-210x300.jpg.webp" alt="Portrait of Arthur D. Levinson, Ph.D." src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 210px; --smush-placeholder-aspect-ratio: 210/300;" /><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2021/06/Art_4--e1623433634553-210x300.jpg" alt="Portrait of Arthur D. Levinson, Ph.D."/></noscript> </figure> <span class="name">Arthur D. Levinson, Ph.D.</span> <span class="role">Founder & CEO</span> </cite> </div> </a> </blockquote> </div> </div> <div id="sizing_container_block_088fdda76135feda24989fe36fc1b2cf" class="sizing-container section__margin_auto container__small mt-0 mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h4 id="heading_block_e9177931eb5622f9c272ce09a62605aa" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default eyebrow align-left align-left-mobile" style="color:#000000;"> We are different by design </h4> <h2 id="heading_block_56a4552fd75add1a8056a04b39cb5308" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Think big. Explore broadly. Collaborate constantly. </h2> <p>Our mission is said simply, yet it is quite ambitious. We are working to better understand the biology that controls aging and lifespan… and we are using the knowledge we gain to discover and develop interventions that enable people to lead longer and healthier lives.</p> <p class="is-style-text-highlight">We are not a traditional biotechnology company, nor are we an academic institution. We have combined the best parts of both without the constraints of either.</p> <p>We are asking difficult questions about how we age and the diseases associated with the aging process. To find answers requires a long-term perspective, a relentless focus on understanding the basic biology of aging, utilizing and inventing state-of-the-art technology, enlisting advanced computing capabilities and nurturing a culture and values that guide the big and small decisions we make every day.</p> <p>Our progress is charted in high-quality publications, our many collaborations and the expanding pipeline of early- and clinical-stage compounds that target diseases commonly linked with aging.</p> </div> </div> </div> </section> <section id="page_section_block_c52d04d902fceae58bb50f8c63abeddf" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_image has_overlay bg_fill_dt_contain bg_fill_mb_cover block_background__media sbg_top sbg_top_dt_custom sbg_top_mb_none sbg_top_below" style="--bg-position-x-dt:right;--bg-position-y-dt:top;--bg-position-x-mb:right;--bg-position-y-mb:center;--overlay:;--bg-height-dt:1600px;--bg-width-mb:100%;--bg-height-mb:100%;--sbg-top-size-dt:250px;--sbg-top-color:#f1efeb;"> <div class="acf-innerblocks-container"> <div id="sizing_container_block_5d01a0ffaec87c13936c5b3375c47ec3" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <div class="cardLinks mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default " id="card_links_block_30232a1daefec85dcfa0464397cbbb64" style=" "> <div class="cardLinks__container"> <div class="cardLinks__item from-bottom__0" href="https://calicolabs.wpenginepowered.com/research-technology/"> <div class="cardLinks__item__container"> <figure class="cardLinks__item__img"> <img decoding="async" class="image lazyload" data-src="https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-789x1024.jpg.webp" data-srcset="https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-789x1024.jpg.webp 789w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-231x300.jpg.webp 231w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-768x997.jpg.webp 768w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-1184x1536.jpg.webp 1184w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-1578x2048.jpg.webp 1578w, https://www.calicolabs.com/wp-content/smush-webp/2022/10/Brian-with-plate-reader-cropped-scaled.jpg.webp 1973w" data-sizes="(max-width: 2000px) 100vw, 2000px" alt="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 789px; 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Can we delay its start or reduce its speed? We believe the answer to these questions will be found in systems biology." </p> </div> <div class="quote-attribution from-bottom__1"> <div class="quote-link-container t-cite"> <a class="quote-link no_underline " href="https://www.calicolabs.com/people/eugene-melamud/"> Eugene Melamud, Ph.D. </a> </div> <div class="quote-role-container"> <span class="quote-role sentinel-italic"> Principal Investigator </span> </div> </div> </div> </div> </div> </div> </div> </div> <div id="sizing_container_block_f12512ac3723219419033ef4cdd195ae" class="sizing-container section__margin_auto container__extra-large mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <div class="featuredCard mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default " id="featured_card_block_f60c591ded72344319d151c010502513" style=" "> <div class="featuredCard post-1628 lab_story type-lab_story status-publish has-post-thumbnail hentry category-technology from-bottom__0"> <div class="featuredCard__container">  <div class="featuredCard__ribbon from-bottom__0"> <p class="t-label-small"> Featured Story </p> </div>  <div class="featuredCard__heading"> <div class="featuredCard__heading-container">   <div class="featuredCard__date from-bottom__0"> <span> April 15, 2020 </span> </div>  <div class="featuredCard__title from-bottom__0"> <h4> <a href="https://www.calicolabs.com/story/the-experiment-that-started-it-all/" target="_self"> The experiment that started it all </a> </h4> </div>  <p class="featuredCard__description t-body-large from-bottom__0"> In 1993, aging science was barely a field of study. Many scientists believed that aging “just happened.” Since aging happens after reproduction, the thinking went, genes for… </p>  </div>  <div class="featuredCard__buttons from-bottom__0"> <div class="primary-button"> <a id="1628" class="btn btn__outlined white " style="" href="https://www.calicolabs.com/story/the-experiment-that-started-it-all/" target="_self">Read Story</a> </div> <div class="secondary-button"> <a id="1628" class="btn btn__simple white " style="" href="https://www.calicolabs.com/calico-stories/" target="_self">See More Stories</a> </div> </div> </div>  <figure class="featuredCard__img"> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/smush-webp/2020/04/The-experiment-that-started-it-all-@2x-1024x532.jpg.webp" data-srcset="https://www.calicolabs.com/wp-content/smush-webp/2020/04/The-experiment-that-started-it-all-@2x-1024x532.jpg.webp 1024w, 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