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Friday, February 21, 2025</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_SCIENCE" target="_blank" href="https://clarivate.com/news/bioworld-by-clarivate-releases-comprehensive-2024-year-in-review/">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/717493-five-med-tech-trends-to-watch-in-2025">Breaking News: Five med-tech trends to watch in 2025</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a></section><section class="featured-stories__wrapper -primary-4 --secondary-4"><div class="featured-stories__primary "><section class="featured-stories "> <div class="featured-stories__items-wrapper"><ul class="featured-stories__items featured-stories__items-1"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><figure class="featured-stories__image"><a class="featured-stories__thumbnail-link" data-eventname="featured-stories" data-eventcategory="click" data-eventaction="featured-stories-image" data-eventlabel="https://www.bioworld.com/articles/717404-evo-2-ai-allows-genome-and-epigenome-modeling-of-all-life-domains" href="https://www.bioworld.com/articles/717404-evo-2-ai-allows-genome-and-epigenome-modeling-of-all-life-domains"><img class="featured-stories__image-thumb" alt="EVO1 diagram" title="EVO1 diagram" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-source/EVO1-diagram.jpg?height=355&t=1740151157&width=640" /></a></figure><div class="featured-stories__details featured-stories__details-1"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717404-evo-2-ai-allows-genome-and-epigenome-modeling-of-all-life-domains">Evo 2 AI allows genome and epigenome modeling of all life domains </a></h1><div class="featured-stories__teaser">A new version of Evo, the AI developed at the Arc Institute that can be used to design genomes as long as that of a bacterium, has been retrained with the DNA sequences of three domains of life – viruses, bacteria and eukaryotes. Evo 2 identifies patterns in DNA sequences, mutations that cause disease in humans, and open chromatin indicating which genes are active.</div></div></article> </li> </ul><ul class="featured-stories__items featured-stories__items-2"> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717405-hsa-conjugation-prolongs-blood-circulation-improves-tumor-targeting-ability-of-aptamers">HSA-conjugation prolongs blood circulation, improves tumor-targeting ability of aptamers</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717406-thetis-pharmaceuticals-tp-317-shows-promising-effects-in-experimental-colitis-and-ileitis">Thetis Pharmaceuticals' TP-317 shows promising effects in experimental colitis and ileitis</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717407-photys-licenses-rights-to-polymeds-irak-4-degrader">Photys licenses rights to Polymed’s IRAK-4 degrader</a></h1></article> </li> </ul></div> </section></div><div class="featured-stories__secondary"><section class="featured-stories "> <ul class="featured-stories__items"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717404-evo-2-ai-allows-genome-and-epigenome-modeling-of-all-life-domains">Evo 2 AI allows genome and epigenome modeling of all life domains </a></h1><div class="featured-stories__teaser">A new version of Evo, the AI developed at the Arc Institute that can be used to design genomes as long as that of a bacterium, has been retrained with the DNA sequences of three domains of life – viruses, bacteria and eukaryotes. Evo 2 identifies patterns in DNA sequences, mutations that cause disease in humans, and open chromatin indicating which genes are active.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717405-hsa-conjugation-prolongs-blood-circulation-improves-tumor-targeting-ability-of-aptamers">HSA-conjugation prolongs blood circulation, improves tumor-targeting ability of aptamers</a></h1><div class="featured-stories__teaser">Aptamers are single-stranded DNA or RNA molecules with unique 3D structures that allow for specific binding to a wide variety of ions and molecules. Due to their unique properties, aptamers have been extensively studied for the precise detection and treatment of cancer; however, their susceptibility to nuclease degradation and rapid renal clearance represent challenges that limit theranostic time window and effectiveness. Researchers from Huazhong University of Science and Technology evaluated the potential of a novel albumin-conjugation strategy that would improve tumor targeting of the aptamers.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717406-thetis-pharmaceuticals-tp-317-shows-promising-effects-in-experimental-colitis-and-ileitis">Thetis Pharmaceuticals' TP-317 shows promising effects in experimental colitis and ileitis</a></h1><div class="featured-stories__teaser">Thetis Pharmaceuticals LLC has presented preclinical data on their BLT1 receptor agonist TP-317 as an approach for treating inflammatory bowel disease. BLT1 activation promotes immune homeostasis and repair; oral therapy with TP-317 was investigated in two preclinical models of colitis and ileitis.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717407-photys-licenses-rights-to-polymeds-irak-4-degrader">Photys licenses rights to Polymed’s IRAK-4 degrader</a></h1><div class="featured-stories__teaser">Photys Therapeutics Inc. has signed a license agreement with Hangzhou Polymed Biopharmaceuticals Inc. for HPB-143, a phase I-ready IRAK-4 degrader. IRAK-4 degradation offers potential to treat various autoimmune indications, including atopic dermatitis and hidradenitis suppurativa.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717660-other-news-to-note-for-feb-21-2025">Other news to note for Feb. 21, 2025</a></h1><div class="featured-stories__teaser">Additional early-stage research and drug discovery news in brief.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717493-five-med-tech-trends-to-watch-in-2025">Five med-tech trends to watch in 2025</a></h1><div class="featured-stories__teaser">The Clarivate Medtech Trends to Watch in 2024 report noted the resilience of the medtech sector in the face of changing macroeconomic factors and the preparation required to navigate the market’s many complexities. It is likely that 2025 will be no different. </div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717408-mbx-biosciences-unveils-new-long-acting-antiobesity-asset">MBX Biosciences unveils new, long-acting antiobesity asset </a></h1><div class="featured-stories__teaser">Researchers from MBX Biosciences Inc. presented preclinical data on MBX-4291, a prodrug developed as a long-acting GLP-1/GIP co-agonist through MBX’s proprietary Precision Endocrine Peptide (PEP) platform.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717410-potential-first-in-class-fem1b-recruiting-histone-deacetylase-degraders-divulged">Potential first-in-class FEM1B-recruiting histone deacetylase degraders divulged </a></h1><div class="featured-stories__teaser">Targeted protein degradation (TPD) is an alternative to conventional protein inhibition that is gaining attention due to advantages such as ensuring complete elimination of the target protein, reduced off-target effects or the potential to target previously inaccessible or “undruggable” proteins. Proteolysis targeting chimeras (PROTACs) are agents used for TPD that have proven effective for degradation of histone deacetylase (HDAC), among other different proteins.</div></article> </li> </ul> </section></div><div class="news-service articles-by-site-placement-tax"><section class="featured-stories-by-site-placement__wrapper"><section class="featured-stories-by-site-placement "> <div class="featured-stories-by-site-placement__items-wrapper"><ul class="featured-stories-by-site-placement__items featured-stories-by-site-placement__items-1"> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" 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/></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717416-adcentrx-patents-new-antibody-drug-conjugates">Adcentrx patents new antibody-drug conjugates</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717417-beijing-earthwise-technology-divulges-new-cbl-b-inhibitors">Beijing Earthwise Technology divulges new CBL-B inhibitors</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717411-runx2-regulated-lepr-fibroblasts-significantly-contribute-to-pathological-fibroblasts-in-fibrosis">RUNX2-regulated LEPR+ fibroblasts significantly contribute to pathological fibroblasts in fibrosis</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" 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discovers new GLP-1R agonists</a></h1></div></article> </li> </ul></div> </section></section></div></section><div class="topic-podcast"><div class="adplugg-tag" data-adplugg-zone="bioworld_science_banner"></div><section class="bioworld-podcasts-component"><div class="bioworld-podcasts-component__wrapper"><div class="bioworld-podcasts-component__content"><h3 class="bioworld-podcasts-component__headline"><a class="bioworld-podcasts-component__headline-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast">BioWorld Insider Podcast</a></h3><div class="bioworld-podcasts-component__body"><img src="https://www.bioworld.com/ext/resources/Podcast-files/play-circle-button.png?1718131949" style="display: inline-block; vertical-align: bottom; margin: 5px 0px 5px 5px; text-align: right; float: right; max-width: calc(100% - 5px); width: 95px;" alt="Play button" data-uuid="YTAtMTE1OTM1" align="right">The <em>BioWorld Insider</em> podcast is a monthly dive into the business and science of drug development. Conversations with CEOs and <em>BioWorld</em> analysts in the past 12 months have included a wide range of chats with experts who are shaping the future.</div><a class="bioworld-podcasts-component__link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast">Listen now</a><div class="bioworld-podcasts-component__adplugg-ad"><div class="adplugg-tag" data-adplugg-zone="bioworld_podcasts_science"></div></div></div></div></section></div><section class="topics-section__wrapper"><div class="topics-section__primary"><section class="topics-section "> <h1 class="topics-section__title"><a class="topics-section__title-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-title" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">Conferences</a></h1><ul class="topics-section__items"> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717389-recludix-pharma-gives-update-on-stat6-program" href="https://www.bioworld.com/articles/717389-recludix-pharma-gives-update-on-stat6-program"><img class="topics-section__image-thumb" alt="Skin irritation on hands" title="Skin irritation on hands" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Dermatologic/Dermatologic-atopic-dermatitis2.png?height=355&t=1588885160&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717389-recludix-pharma-gives-update-on-stat6-program">Recludix Pharma gives update on STAT6 program </a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/250,520">Immune</a></div><div class="topics-section__teaser">Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family involved in the regulation of immune response and inflammation. The development of SH2 domain inhibitors targeting STAT6 may help prevent and treat allergic diseases, asthma, atopic dermatitis or other...</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717387-tlt-101-cbin1-gene-therapy-reverses-heart-failure-in-animal-models">TLT-101 cBIN1 gene therapy reverses heart failure in animal models</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div><div class="topics-section__teaser">Researchers from Tikkunlev Therapeutics Inc. and the University of Utah have presented preclinical data on TLT-101, a gene therapy consisting of an adeno-associated virus serotype 9 (AAV9) vector encoding cardiac bridging integrator 1 (cBIN1) designed for the treatment of heart failure.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717327-trop2-is-a-prognostic-factor-in-urachal-carcinoma" href="https://www.bioworld.com/articles/717327-trop2-is-a-prognostic-factor-in-urachal-carcinoma"><img class="topics-section__image-thumb" alt="Microscope" title="Microscope" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Microscope.png?height=355&t=1588876288&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717327-trop2-is-a-prognostic-factor-in-urachal-carcinoma">TROP2 is a prognostic factor in urachal carcinoma</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/543,520">Biomarkers</a></div><div class="topics-section__teaser">Urachal carcinoma is a rare cancer which lacks a standard drug therapy, and for which knowledge regarding its immunohistochemical features remains unclear. The aim of a recently reported investigation was finding potential markers and targets for urachal carcinoma based on antibody-drug conjugate...</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717321-researchers-develop-new-glioblastoma-murine-model">Researchers develop new glioblastoma murine model</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="topics-section__teaser">The research on glioblastoma requires the development of new preclinical murine models. The GL261 cell line forms glioma-like tumors in a reliable manner when transplanted intracranially, but these tumors do not completely mimic human glioblastoma. This model responds well to immune checkpoint...</div></div></article> </li> </ul><a class="topics-section__more-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-more-link" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">More in Conferences</a> </section></div><div class="topics-section__aside"><section class="news-in-brief "> <h1 class="news-in-brief__title">Today's news in brief</h1><ul class="news-in-brief__items"> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/717421-other-news-to-note-for-feb-21-2025">Other news to note for Feb. 21, 2025</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689316-respiratory">Respiratory</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689317-dermatologic">Dermatologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689318-cardiovascular">Cardiovascular</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689319-hematologic">Hematologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689320-nephrology">Nephrology</a></h1></article> </li> </ul> </section></div></section><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/472-patents" href="/articles/topic/472-patents">Patents</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717402-hangzhou-zhongmei-huadong-pharmaceutical-discovers-new-gspt1-degradation-inducers">Hangzhou Zhongmei Huadong Pharmaceutical discovers new GSPT1 degradation inducers</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717401-integrin-47-antagonists-disclosed-in-galapagos-patent">Integrin α4β7 antagonists disclosed in Galapagos patent</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717400-arvinas-operations-describes-new-dgk-inhibitors">Arvinas Operations describes new DGK-α inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717399-chengdu-chipscreen-pharmaceutical-divulges-new-prmt5-inhibitors">Chengdu Chipscreen Pharmaceutical divulges new PRMT5 inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717398-sunshine-lake-pharma-patents-new-parp-1-inhibitors">Sunshine Lake Pharma patents new PARP-1 inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717548-shenzhen-zhongge-biotechnology-describes-new-eif2b-activators">Shenzhen Zhongge Biotechnology describes new EIF2B activators</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717547-haisco-pharmaceutical-discovers-new-wrn-inhibitors">Haisco Pharmaceutical discovers new WRN inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717546-new-cyp11b2-inhibitors-disclosed-in-hansoh-patent">New CYP11B2 inhibitors disclosed in Hansoh patent</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717545-beijing-synthetic-vaccine-biosciences-divulges-new-tlr8-agonists">Beijing Synthetic Vaccine Biosciences divulges new TLR8 agonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717544-shanghai-wennai-pharmaceutical-technology-patents-new-nav18-blockers">Shanghai Wennai Pharmaceutical Technology patents new Nav1.8 blockers</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">Cancer</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/717394-dhx9-inhibition-as-strategy-against-msi-h-dmmr-colorectal-cancer" href="https://www.bioworld.com/articles/717394-dhx9-inhibition-as-strategy-against-msi-h-dmmr-colorectal-cancer"><img class="bioworld-biome__image-thumb" alt="Colorectal cancer 3D illustration" title="Colorectal cancer 3D illustration" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Colorectal-cancer-3D-illustration.jpg?height=355&t=1704985372&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717394-dhx9-inhibition-as-strategy-against-msi-h-dmmr-colorectal-cancer">DHX9 inhibition as strategy against MSI-H/dMMR colorectal cancer</a></h1><div class="bioworld-biome__teaser">Elevated expression of DHX9 has been reported in multiple cancer types and it is associated with poor prognosis. In a recently published study, researchers from Accent Therapeutics Inc. evaluated aimed to assess the role of DHX9 in cancer using the tool compound ATX-968, designed as a potent and...</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717393-io-112-modulates-tumor-macrophages-allows-control-of-tumor-microenvironment">IO-112 modulates tumor macrophages, allows control of tumor microenvironment</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/280,520">Immuno-oncology</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717392-ba-4415-an-anti-pd-l1-cd40-bispecific-antibody-for-cancer-immunotherapy">BA-4415, an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/273,520">Bispecific antibody</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717390-epitopea-and-msd-collaborate-to-discover-tumor-specific-antigens-for-solid-tumor">Epitopea and MSD collaborate to discover tumor-specific antigens for solid tumor</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/217,520">Collaboration</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717386-clots-and-metastasis-in-cancer-patients-start-in-the-lung">Clots and metastasis in cancer patients start in the lung</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">More in Cancer</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_1"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">Infection</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/717388-guab-inhibitor-for-tuberculosis-treatment-described" href="https://www.bioworld.com/articles/717388-guab-inhibitor-for-tuberculosis-treatment-described"><img class="clinical__image-thumb" alt="Colorized scanning electron micrograph of M. tuberculosis bacteria." title="Colorized scanning electron micrograph of M. tuberculosis bacteria." width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-Mycobacterium-tuberculosis-Bacteria-TB.png?height=355&t=1663950110&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717388-guab-inhibitor-for-tuberculosis-treatment-described">GuaB inhibitor for tuberculosis treatment described</a></h1><div class="clinical__teaser">Tuberculosis (TB) is a serious infectious disease caused by the bacterium <em>Mycobacterium tuberculosis</em>. While multidrug treatment regimens are the standard of care, the lengthy treatment schedule and the emergence of drug-resistant TB highlight the need for new therapeutic options to address these...</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717376-kvx-053-alleviates-acute-lung-injury-in-covid-19">KVX-053 alleviates acute lung injury in COVID-19</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/263,520">Respiratory</a></div><div class="clinical__teaser">Researchers from Kevirx Inc. and collaborators have described the use of KVX-053, a PTP4A3 inhibitor aimed to be used for the prevention of COVID-19-associated cute lung injury (ALI).</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717307-discovery-of-new-antibiotic-compounds-against-multidrug-resistant-gram-positive-pathogens">Discovery of new antibiotic compounds against multidrug-resistant gram-positive pathogens</a></h1><div class="clinical__teaser">Researchers from Shanxi Medical University, Nanjing Agricultural University and China Pharmaceutical University, have detailed the discovery and preclinical characterization of antibiotic candidates against multidrug-resistant gram-positive pathogens.</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717292-boronic-acid-inhibitors-restore-cefepime-efficacy-in-multidrug-resistant-kpc-producing-emk-pneumoniae-em">Boronic acid inhibitors restore cefepime efficacy in multidrug-resistant KPC-producing <em>K. pneumoniae</em></a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/117,520">Drug resistance</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717241-gates-foundation-novo-nordisk-foundation-and-wellcome-set-sights-on-antimicrobial-resistance">Gates Foundation, Novo Nordisk Foundation and Wellcome set sights on antimicrobial resistance</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/117,520">Drug resistance</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717239-emplasmodium-em-essential-gene-map-gives-malaria-pharmacologic-clues"><em>Plasmodium</em> essential gene map gives malaria pharmacologic clues</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/249,520">Hematologic</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717237-tb-alliance-discovers-new-clpp1p2-protease-inhibitors-for-tuberculosis">TB Alliance discovers new ClpP1P2 protease inhibitors for tuberculosis</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/472,520">Patents</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">More in Infection</a> </section></div></div></section><div class="deals-m-a__wrapper"><section class="deals-m-a "> <h1 class="deals-m-a__title"><a class="deals-m-a__title-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-title" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">Neurology/psychiatric</a></h1><ul class="deals-m-a__items"> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717316-aqp4-inhibitors-disclosed-in-biocells-biotech-patent">AQP4 inhibitors disclosed in Biocells Biotech patent </a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Biocells (Beijing) Biotech Co. Ltd. has divulged aquaporin-4 (AQP4) inhibitors potentially useful for the treatment of cerebral ischemia.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717315-bial-portela-describes-new-ox1-receptor-antagonists">Bial-Portela describes new OX1 receptor antagonists</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Bial-Portela & Ca SA has identified orexin OX1 receptor antagonists reported to be useful for the treatment of cognitive, sleep, anxiety and eating disorders, depression, obesity, schizophrenia, substance abuse and dependence, among others.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717314-2a-biosciences-divulges-new-5-ht2a-receptor-agonists">2A Biosciences divulges new 5-HT2A receptor agonists</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">2A Biosciences Inc. has synthesized tryptamine derivatives acting as 5-HT2A receptor agonists reported to be useful for the treatment of psychiatric, neurodegenerative, neurodevelopmental, inflammatory and eye disorders.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717300-bsense-bio-therapeutics-identifies-new-kcnq2-3-and-trpv1-modulators">Bsense Bio Therapeutics identifies new KCNQ2/3 and TRPV1 modulators</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Bsense Bio Therapeutics Ltd. has disclosed new potassium voltage-gated channel subfamily KQT member 2/3 (KCNQ2/3) activators and transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists reported to be useful for the treatment of neuropathic pain, pruritus and tinnitus.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders" href="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders"><img class="deals-m-a__image-thumb" alt="Brain as light bulb filament" title="Brain as light bulb filament" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Brain-as-filament-in-light-bulb.jpg?height=355&t=1695308372&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders">Mair Therapeutics launches with focus on neurodegenerative disorders</a></h1><div class="deals-m-a__teaser">Mair Therapeutics BV has launched with pre-seed funding from Torrey Pines Investment and Oost NL and with a focus on developing treatments for neurodegenerative disorders, particularly Parkinson’s disease.</div></div></article> </li> </ul><a class="deals-m-a__more-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-more-link" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">More in Neurology/psychiatric</a> </section></div><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/250-immune" href="/articles/topic/250-immune">Immune</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717374-septerna-to-change-candidate-for-hypoparathyroidism">Septerna to change candidate for hypoparathyroidism </a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717305-bispecific-antibody-targeting-kir-and-icos-restores-immune-balance-in-models-of-ibd">Bispecific antibody targeting KIR and ICOS restores immune balance in models of IBD</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717302-adiponectin-blocks-immunotherapy-inflammation-without-impairing-it">Adiponectin blocks immunotherapy inflammation without impairing it</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717299-neumora-therapeutics-reports-nmda-receptor-positive-allosteric-modulators">Neumora Therapeutics reports NMDA receptor positive allosteric modulators</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717286-ensomas-en-374-designated-orphan-drug-for-x-linked-chronic-granulomatous-disease">Ensoma’s EN-374 designated orphan drug for X-linked chronic granulomatous disease</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717243-lycia-therapeutics-advances-protein-degradation-therapies">Lycia Therapeutics advances protein degradation therapies</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717228-microglial-igsf6-knockdown-reduces-ischemic-brain-injury-post-stroke">Microglial IGSF6 knockdown reduces ischemic brain injury post-stroke</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717132-cspcs-herpes-zoster-vaccine-gains-clinical-trial-clearance-in-china">CSPC’s herpes zoster vaccine gains clinical trial clearance in China</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717120-rbm47-a-new-target-to-watch-in-thyroid-associated-ophthalmopathy">RBM47, a new target to watch in thyroid-associated ophthalmopathy</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717035-grifols-collaborates-with-fcr-therapeutics-on-autoimmune-diseases">Grifols collaborates with FcR Therapeutics on autoimmune diseases</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">Endocrine/metabolic</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/717371-intranasal-bacterium-for-targeted-brain-delivery" href="https://www.bioworld.com/articles/717371-intranasal-bacterium-for-targeted-brain-delivery"><img class="bioworld-biome__image-thumb" alt="Nasal spray" title="Nasal spray" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/ENT/Nasal-spray.png?height=355&t=1629404803&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717371-intranasal-bacterium-for-targeted-brain-delivery">Intranasal bacterium for targeted brain delivery</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/544,520">Drug design, drug delivery and technologies</a></div><div class="bioworld-biome__teaser">In a recent publication in <em>Cell</em>, researchers from the National University of Singapore and collaborators have proposed using commensal bacteria in the nasal cavity as a delivery vector for precision therapy targeting the OE and brain.</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases">Seed funding at Junevity supports siRNA therapeutics for age-related diseases</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/566,520">Aging</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717247-scaav9-sumf1-shows-safety-and-efficacy-as-gene-replacement-therapy-for-the-treatment-of-multiple-sulfatase-deficiency">scAAV9/SUMF1 shows safety and efficacy as gene replacement therapy for the treatment of multiple sulfatase deficiency</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/278,520">Gene therapy</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity">Adrenomedullin pathway leads to insulin resistance in obesity </a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717116-new-prophylactic-immunomodulation-for-upcoming-4d-310-trials-presented">New prophylactic immunomodulation for upcoming 4D-310 trials presented</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">More in Endocrine/metabolic</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_2"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">Biomarkers</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia" href="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia"><img class="clinical__image-thumb" alt="3D illustration showing presence of tumor inside prostate gland " title="3D illustration showing presence of tumor inside prostate gland " width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-prostate-illustration.jpg?height=355&t=1721842077&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia">RNA panel detects and differentiates prostate cancer from benign prostate hyperplasia</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">Prostate cancer is still one of the main causes of cancer death among men; while prostate-specific antigen (PSA) testing is done for screening, there are recommendations against its use due to its nonspecific and suboptimal results. There is thus an urgent need for new biomarkers that are more...</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717192-cdca4-as-new-molecular-target-for-bladder-cancer">CDCA4 as new molecular target for bladder cancer</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="clinical__teaser">Previous research has shown that cell division cycle associated 4 (CDCA4) is overexpressed in multiple tumors and is involved in tumor progression. Researchers from Yangtze University and affiliated organizations investigated the role of CDCA4 in bladder cancer.</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716615-ep400-variants-linked-to-epilepsy-neurodevelopmental-disorders">EP400 variants linked to epilepsy, neurodevelopmental disorders</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/256,520">Neurology/psychiatric</a></div><div class="clinical__teaser">Researchers from Guangzhou Medical University and affiliated organizations presented data from a study that aimed to investigate the disease-causing mechanism of EP400, a gene that encodes the E1A binding protein p400, which is a core catalytic ATPase subunit of ATP-dependent chromatin remodeling...</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716568-dap3-gene-behind-perrault-syndrome-study-finds">DAP3 gene behind Perrault syndrome, study finds</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/548,520">Genetic/congenital</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716491-wnt-pcp-signaling-mediators-identified-as-new-markers-in-yellow-nail-syndrome">Wnt/PCP signaling mediators identified as new markers in yellow nail syndrome</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/242,520">Dermatologic</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716320-new-findings-tie-tlx3-to-autism-spectrum-disorder">New findings tie TLX3 to autism spectrum disorder</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/256,520">Neurology/psychiatric</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/715806-rare-btnl8-variants-associated-with-altered-intestinal-permeability-are-enriched-in-mis-c-patients">Rare BTNL8 variants associated with altered intestinal permeability are enriched in MIS-C patients</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/250,520">Immune</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">More in Biomarkers</a> </section></div></div></section><section class="topics-section-3__wrapper"><div class="topics-section-3__col"><section class="regulatory "> <h1 class="regulatory__title"><a class="regulatory__title-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-title" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">Gastrointestinal</a></h1><ul class="regulatory__items"> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717303-series-a-financing-at-bambusa-to-advance-bispecific-antibodies-for-immunological-and-inflammatory-disorders">Series A financing at Bambusa to advance bispecific antibodies for immunological and inflammatory disorders</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/292,520">Financings</a></div><div class="regulatory__teaser">Bambusa Therapeutics Inc. has completed an oversubscribed series A financing of approximately $90 million to support its lead programs through phase I trials and advance its pipeline of long-acting bispecific antibodies for immunological and...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717223-hmga1-modulates-wnt-driven-tumorigenesis-in-colorectal-cancer">HMGA1 modulates Wnt-driven 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