Diagnostic Procedures - Learn - PLCO - The Cancer Data Access System

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href="/news/90/"> <span class="date">Dec 26, 2024</span> <span class="title">New PLCO Data Added</span> </a> <a class="newsitem" href="/news/89/"> <span class="date">Dec 26, 2024</span> <span class="title">Updated PLCO Data</span> </a> </div> </div> </div> <div class="col-md-9" id="maincontent"> <div class="page-header"> <h2>Diagnostic Procedures</h2> </div> <div class="tabs-responsive"> <ul id="request-tabs" class="nav nav-tabs"> <li class="nav-item learn-tab-li" id="tab-link-prostate"> <a class="nav-link active" href="/learn/plco/dx-procs/prostate/" onclick="$.tabs.loadLearnTab('tab-prostate',this,3,'Prostate','Diagnostic Procedures'); return false;" aria-selected="true" aria-controls="tab-prostate">Prostate <span class="sr-only"> Tab</span></a> </li> <li class="nav-item learn-tab-li" id="tab-link-lung"> <a class="nav-link" href="/learn/plco/dx-procs/lung/" onclick="$.tabs.loadLearnTab('tab-lung',this,3,'Lung','Diagnostic Procedures'); return false;" aria-selected="false" aria-controls="tab-lung">Lung <span class="sr-only"> Tab</span></a> </li> <li class="nav-item learn-tab-li" id="tab-link-colorectal"> <a class="nav-link" href="/learn/plco/dx-procs/colorectal/" onclick="$.tabs.loadLearnTab('tab-colorectal',this,3,'Colorectal','Diagnostic Procedures'); return false;" aria-selected="false" aria-controls="tab-colorectal">Colorectal <span class="sr-only"> Tab</span></a> </li> <li class="nav-item learn-tab-li" id="tab-link-ovarian"> <a class="nav-link" href="/learn/plco/dx-procs/ovarian/" onclick="$.tabs.loadLearnTab('tab-ovarian',this,3,'Ovarian','Diagnostic Procedures'); return false;" aria-selected="false" aria-controls="tab-ovarian">Ovarian <span class="sr-only"> Tab</span></a> </li> <li class="nav-item learn-tab-li" id="tab-link-asu"> <a class="nav-link" href="/learn/plco/dx-procs/asu/" onclick="$.tabs.loadLearnTab('tab-asu',this,3,'Annual Study Update','Diagnostic Procedures'); return false;" aria-selected="false" aria-controls="tab-asu">Annual Study Update <span class="sr-only"> Tab</span></a> </li> </ul> </div> <div class='tab-content' id='tab-prostate'> <h3>Prostate</h3> <p> Data was collected on procedures that were part of a diagnostic work-up for prostate cancer and for staging procedures following a diagnosis. Two different types of events triggered the collection of diagnostic procedure information: </p> <ol class="diagnostic"> <li> <strong>Screens suspicious for prostate cancer:</strong> Among approximately 36,000* men screened once a year for up to 6 years, there were about 23,000 screening PSA exams or Digital Rectal Exams (DREs) suspicious for prostate cancer. These "positive" exams triggered further diagnostic follow-up, which was systematically captured, in most cases, for up to one year following the screen. Any positive screen among the PSA, DRE and, less frequently a QA exam would refer a participant to further follow-up. This information was captured regardless of the eventual diagnosis. </li> <li> <strong>Confirmed diagnoses of prostate cancer:</strong> When a participant was diagnosed with prostate cancer within the trial period, procedures that were part of a diagnostic work-up that occurred in the year leading up to that diagnosis were captured in the data. </li> </ol> <p> Therefore, if a participant had a diagnostic procedure during the trial such that it was neither one year following a positive screen nor one year prior to a prostate cancer diagnosis, that information was not captured. As such, the only diagnostic procedures captured in the control arm are those that eventually lead to a prostate cancer diagnosis. </p> <p> For most purposes, diagnostic procedure data can be obtained within the <a href="/datasets/plco/20/#dataset-45">Prostate dataset</a>. Additional details can be found in the <a href="/datasets/plco/20/#dataset-72">Prostate Diagnostic Procedures dataset</a> (one record per procedure per person) and the <a href="/datasets/plco/20/#dataset-77">Prostate Medical Complications dataset</a> (one record per medical complication per person). </p> <table class="data-collected-table full-width data-collected-table-2column"> <tr> <th scope="col">Summary</th> <th scope="col">Available Data</th> </tr> <tr> <td> <ul> <li>~96,000 procedures among ~15,000 men</li> <li>Collected for the year following a positive screen or the year preceding a prostate cancer diagnosis</li> <li>Collected in the intervention arm for men with prostate cancer or screens suspicious for prostate cancer. (~71,000 procedures among ~11,000 participants)</li> <li>Collected in the control arm only for men with prostate cancer. (~26,000 procedures among ~4200 participants)</li> <li>Collected on DEP (Diagnostic Evaluation - Prostate) forms: <ul> <li>DEP</li> <li>DEP2</li> <li><a href="/files/download/abj3za95sf/DEP3.pdf" target="_blank" rel="noopener noreferrer">DEP3 - Scanned</a> (PDF - 4.3 MB)</li> <li><a href="/files/download/td30ojd7j3/DEP3_accessible.pdf" target="_blank" rel="noopener noreferrer">DEP3 - Accessible</a> (PDF - 200 KB)</li> </ul> </li> </ul> </td> <td> <ul> <li>Whether screens prompted diagnostic procedure(s)</li> <li>Whether screens prompted biopsy</li> <li>Type of biopsy</li> <li>Available in diagnostic procedures dataset: <ul> <li>Types of procedures</li> <li>Days from randomization to procedure</li> <li>PSA level (for PSA exams not part of the screening protocol)</li> <li>Prostate dimensions and volume</li> <li>Form version used to capture information</li> </ul> </li> </ul> </td> </tr> </table> <p> *38,000 men were randomized for screening, but 2,000 never completed screening. </p> </div> <div class='tab-content' id='tab-lung' style='display:none;'> <h3>Lung</h3> <p> Data was collected on procedures that were part of a diagnostic work-up for lung cancer and for staging procedures following a diagnosis. Two different types of events triggered the collection of diagnostic procedure information: </p> <ol class="diagnostic"> <li> <strong>Screens suspicious for lung cancer:</strong> Among approximately 71,000 participants screened once a year for up to 4 years, there were about 18,000 screening chest x-rays suspicious for lung cancer. These "positive" exams triggered further diagnostic follow-up, which was systematically captured, in most cases, for up to one year following the screen. Any positive chest x-ray screen and, less frequently a QA exam would refer a participant to further follow-up. This information was captured regardless of the eventual diagnosis. </li> <li> <strong>Confirmed diagnoses of lung cancer:</strong> When a participant is diagnosed with lung cancer within the trial period, procedures that were part of a diagnostic work-up that occurred in the year leading up to that diagnosis were captured in the data. </li> </ol> <p> Therefore, if a participant had a diagnostic procedure during the trial such that it was neither one year following a positive screen nor one year prior to a lung cancer diagnosis, that information was not captured. As such, the only diagnostic procedures captured in the control arm are those that eventually lead to a lung cancer diagnosis. </p> <p> For most purposes, diagnostic procedure data can be obtained within the <a href="/datasets/plco/21/#dataset-46">Lung dataset</a>. Additional details can be found in the <a href="/datasets/plco/21/#dataset-73">Lung Diagnostic Procedures dataset</a> (one record per procedure per person) and the <a href="/datasets/plco/21/#dataset-78">Lung Medical Complications dataset</a> (one record per medical complication per person). </p> <div class="clearFloat"></div> <table class="data-collected-table full-width data-collected-table-2column"> <tr> <th scope="col">Summary</th> <th scope="col">Available Data</th> </tr> <tr> <td> <ul> <li>~64,000 procedures among ~15,000 participants</li> <li>Collected for the year following a positive screen or the year preceding a lung cancer diagnosis</li> <li>Collected in the intervention arm for participants with lung cancer or screens suspicious for lung cancer. (~48,000 procedures among ~13,000 participants)</li> <li>Collected in the control arm only for participants with lung cancer. (~16,000 procedures among ~1800 participants)</li> <li>Collected on DEL (Diagnostic Evaluation - Lung) forms: <ul> <li>DEL</li> <li>DEL2</li> <li><a href="/files/download/wl3qymkpja/DEL3.pdf" target="_blank" rel="noopener noreferrer">DEL3 - Scanned</a> (PDF - 2.5 MB)</li> <li><a href="/files/download/sb9exra0iv/DEL3_accessible.pdf" target="_blank" rel="noopener noreferrer">DEL3 - Accessible</a> (PDF - 200 KB)</li> </ul> </li> </ul> </td> <td> <ul> <li>Whether screens prompted diagnostic procedure(s)</li> <li>Whether screens prompted biopsy</li> <li>Available in diagnostic procedures data set: <ul> <li>Types of procedures</li> <li>Days from randomization to procedure</li> </ul> </li> </ul> </td> </tr> </table> </div> <div class='tab-content' id='tab-colorectal' style='display:none;'> <h3>Colorectal</h3> <p> Among 22,000 follow-up endoscopies, data was collected on at least 30,000 polyps and 15,000 adenomas seen on endoscopy. Polyp counts, sizes, locations and histologies are included in the data when available. </p> <p> For most purposes, adenoma and polyp data can be obtained within the <a href="/datasets/plco/22/#dataset-47">Colorectal dataset</a>. Additional details can be found in the <a href="/datasets/plco/22/#dataset-88">Colorectal Endoscopies dataset</a> (one record per endoscopy per person) and the <a href="/datasets/plco/22/#dataset-81">Colorectal Polyps dataset</a> (one record per polyp per endoscopy per person). </p> <div class="clearFloat"></div> <table class="data-collected-table full-width data-collected-table-2column"> <tr> <th scope="col">Summary</th> <th scope="col">Available Data</th> </tr> <tr> <td> <ul> <li>~85,000 procedures among ~21,000 participants</li> <li>Collected for the year following a positive screen or the year preceding a colorectal cancer diagnosis</li> <li>Collected in the intervention arm for participants with colorectal cancer or screens suspicious for colorectal cancer. (~72,000 procedures among ~20,000 participants)</li> <li>Collected in the control arm only for participants with colorectal cancer. (~13,000 procedures among ~1500 participants)</li> <li>Collected on DEC (Diagnostic Evaluation - Colorectum) forms: <ul> <li>DEC</li> <li>DEC2</li> <li><a href="/files/download/kq0zgo21de/DEC3.pdf" target="_blank" rel="noopener noreferrer">DEC3 - Scanned</a> (PDF - 3.2 MB)</li> <li><a href="/files/download/x60qnvlcsn/DEC3_accessible.pdf" target="_blank" rel="noopener noreferrer">DEC3 - Accessible</a> (PDF - 200 KB)</li> </ul> </li> </ul> </td> <td> <ul> <li>Whether screens prompted diagnostic procedure(s)</li> <li>Whether screens prompted endoscopy</li> <li>Type of endoscopy</li> <li>Whether adenoma seen on endoscopy</li> <li>Adenoma location (i.e., distal or proximal)</li> <li>Available in diagnostic procedures, endoscopy and polyp datasets: <ul> <li>Types of procedures</li> <li>Days from randomization to procedure</li> <li>Bowel preparation for endoscopy</li> <li>Cecum visualization at endoscopy</li> <li>Adenoma location (e.g., sigmoid)</li> <li>Whether adenoma is advanced</li> <li>Whether adenoma is villous</li> <li>Form version used to capture information</li> </ul> </li> </ul> </td> </tr> </table> <p> *77,000 participants were randomized for screening, but 10,000 never completed screening. </p> </div> <div class='tab-content' id='tab-ovarian' style='display:none;'> <h3>Ovarian</h3> <p> Data was collected on procedures that were part of a diagnostic work-up for ovarian cancer and for staging procedures following a diagnosis. Two different types of events triggered the collection of diagnostic procedure information: </p> <ol class="diagnostic"> <li> <strong>Screens suspicious for ovarian cancer:</strong> Among approximately 31,000 women screened once a year for up to 6 years, there were about 6,000 screening CA-125 exams or Transvaginal Ultrasounds (TVUs) suspicious for ovarian cancer. These "positive" exams triggered further diagnostic follow-up, which was systematically captured, in most cases, for up to one year following the screen. Any positive screen among the CA-125, TVU and, less frequently a QA exam would refer a participant to further follow-up. This information was captured regardless of the eventual diagnosis. </li> <li> <strong>Confirmed diagnoses of ovarian cancer:</strong> When a participant is diagnosed with ovarian cancer within the trial period, procedures that were part of a diagnostic work-up that occurred in the year leading up to that diagnosis were captured in the data. </li> </ol> <p> Therefore, if a participant had a diagnostic procedure during the trial such that it was neither one year following a positive screen nor one year prior to a ovarian cancer diagnosis, that information was not captured. As such, the only diagnostic procedures captured in the control arm are those that eventually lead to an ovarian cancer diagnosis. </p> <p> For most purposes, diagnostic procedure data can be obtained within the <a href="/datasets/plco/23/#dataset-48">Ovarian dataset</a>. Additional details can be found in the <a href="/datasets/plco/23/#dataset-75">Ovarian Diagnostic Procedures dataset</a> (one record per procedure per person) and the <a href="/datasets/plco/23/#dataset-80">Ovarian Medical Complications dataset</a> (one record per medical complication per person). </p> <div class="clearFloat"></div> <table class="data-collected-table full-width data-collected-table-2column"> <tr> <th scope="col">Summary</th> <th scope="col">Available Data</th> </tr> <tr> <td> <ul> <li>~19,000 procedures among ~3900 women</li> <li>Collected for the year following a positive screen or the year preceding an ovarian cancer diagnosis</li> <li>Collected in the intervention arm for women with ovarian cancer or screens suspicious for ovarian cancer. (~17,000 procedures among ~3700 participants)</li> <li>Collected in the control arm only for participants with ovarian cancer. (~2300 procedures among ~230 participants)</li> <li>Collected on DEO (Diagnostic Evaluation - Ovarian) forms: <ul> <li>DEO</li> <li>DEO2</li> <li><a href="/files/download/bre8rdditd/DEO3.pdf" target="_blank" rel="noopener noreferrer">DEO3 - Scanned</a> (PDF - 3.1 MB)</li> <li><a href="/files/download/207fltim9d/DEO3_accessible.pdf" target="_blank" rel="noopener noreferrer">DEO3 - Accessible</a> (PDF - 200 KB)</li> </ul> </li> </ul> </td> <td> <ul> <li>Whether screens prompted diagnostic procedure(s)</li> <li>Whether screens prompted biopsy</li> <li>Available in diagnostic procedures data set: <ul> <li>Types of procedures</li> <li>Days from randomization to procedure</li> <li>CA-125 level (for CA-125 exams not part of the screening protocol)</li> </ul> </li> </ul> </td> </tr> </table> </div> <div class='tab-content' id='tab-asu' style='display:none;'> <h3>Annual Study Update</h3> <p> The Annual Study Update (ASU) was used to ascertain cancer diagnosis. The ASU was mailed annually to participants who were alive and remained in the study. Participants were asked if they were diagnosed with cancer, the type of cancer, date of diagnosis, hospital or clinic of diagnosis and physician contact information. In addition, men were asked if they were taking Proscar or Propecia (Finasteride). </p> <p> Over 1.7 million ASUs were expected for participants who were alive and remained in the study through 2009. Of those expected ASUs, 93% were completed. </p> <p> Annual Study Update data and documentation are incorporated into each of the <a href="/datasets/plco/">cancer datasets</a>. </p> <p> Data was collected on the following form: </p> <ul> <li><a href="/files/download/ey2r3sravz/ASU.pdf" target="_blank" rel="noopener noreferrer">ASU - Scanned</a> (PDF - 83 KB)</li> <li><a href="/files/download/xfhxlc6pm1/ASU_accessible.pdf" target="_blank" rel="noopener noreferrer">ASU - Accessible</a> (PDF - 19 KB)</li> </ul> </div> </div> </div> </div> <div id="footer" class="container-fluid"> <ul> <li><a href="/">CDAS Home</a></li> <li> <a href="/contact/plco/">Contact Us</a> </li> <li><a href="/search/">Search this Site</a></li> <li><a href="/policies/">Policies</a></li> <li><a href="https://www.cancer.gov/policies/disclaimer">Disclaimer</a></li> <li><a href="https://www.cancer.gov/policies/accessibility">Accessibility</a></li> <li><a href="https://www.cancer.gov/policies/foia">FOIA</a></li> <li><a href="https://www.hhs.gov/vulnerability-disclosure-policy">HHS Vulnerability Disclosure</a></li> </ul> <ul> <li><a href="https://www.hhs.gov/">U.S. Department of Health and Human Services</a></li> <li><a href="https://www.nih.gov/">National Institutes of Health</a></li> <li><a href="https://www.cancer.gov/">National Cancer Institute</a></li> <li><a href="https://www.usa.gov/">USA.gov</a></li> </ul> <p>NIH... 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Diagnostic Procedures - Learn - PLCO - The Cancer Data Access System