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class="vector-toc-text"> <span class="vector-toc-numb">5.2.2</span> <span>Distribution</span> </div> </a> <ul id="toc-Distribution-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Metabolism" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Metabolism"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2.3</span> <span>Metabolism</span> </div> </a> <ul id="toc-Metabolism-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Elimination" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Elimination"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2.4</span> <span>Elimination</span> </div> </a> <ul id="toc-Elimination-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Chemistry" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Chemistry"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Chemistry</span> </div> </a> <ul id="toc-Chemistry-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Society and culture</span> </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Society and culture subsection</span> </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Changing_medical_practices" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Changing_medical_practices"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Changing medical practices</span> </div> </a> <ul id="toc-Changing_medical_practices-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Atenolol</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 34 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-34" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">34 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A3%D8%AA%D9%8A%D9%86%D9%88%D9%84%D9%88%D9%84" title="أتينولول – Arabic" lang="ar" hreflang="ar" data-title="أتينولول" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A2%D8%AA%D9%86%D9%88%D9%84%D9%88%D9%84" title="آتنولول – South Azerbaijani" lang="azb" hreflang="azb" data-title="آتنولول" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Atenolol" title="Atenolol – Bosnian" lang="bs" hreflang="bs" data-title="Atenolol" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Atenolol" title="Atenolol – Catalan" lang="ca" hreflang="ca" data-title="Atenolol" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Atenolol" title="Atenolol – Welsh" lang="cy" hreflang="cy" data-title="Atenolol" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Atenolol" title="Atenolol – German" lang="de" hreflang="de" data-title="Atenolol" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%91%CF%84%CE%B5%CE%BD%CE%BF%CE%BB%CF%8C%CE%BB%CE%B7" title="Ατενολόλη – Greek" lang="el" hreflang="el" data-title="Ατενολόλη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Atenolol" title="Atenolol – Spanish" lang="es" hreflang="es" data-title="Atenolol" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A2%D8%AA%D9%86%D9%88%D9%84%D9%88%D9%84" title="آتنولول – Persian" lang="fa" hreflang="fa" data-title="آتنولول" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/At%C3%A9nolol" title="Aténolol – French" lang="fr" hreflang="fr" data-title="Aténolol" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%95%84%ED%85%8C%EB%86%80%EC%98%AC" title="아테놀올 – Korean" lang="ko" hreflang="ko" data-title="아테놀올" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Atenolol" title="Atenolol – Croatian" lang="hr" hreflang="hr" data-title="Atenolol" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Atenolol" title="Atenolol – Indonesian" lang="id" hreflang="id" data-title="Atenolol" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Atenololo" title="Atenololo – Italian" lang="it" hreflang="it" data-title="Atenololo" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%98%D7%A0%D7%95%D7%9C%D7%95%D7%9C" title="אטנולול – Hebrew" lang="he" hreflang="he" data-title="אטנולול" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Atenolol" title="Atenolol – Hungarian" lang="hu" hreflang="hu" data-title="Atenolol" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%85%E0%B4%B1%E0%B5%8D%E0%B4%B1%E0%B4%A8%E0%B5%86%E0%B4%B2%E0%B5%8B%E0%B5%BE" title="അറ്റനെലോൾ – Malayalam" lang="ml" hreflang="ml" data-title="അറ്റനെലോൾ" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Atenolol" title="Atenolol – Dutch" lang="nl" hreflang="nl" data-title="Atenolol" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A2%E3%83%86%E3%83%8E%E3%83%AD%E3%83%BC%E3%83%AB" title="アテノロール – Japanese" lang="ja" hreflang="ja" data-title="アテノロール" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%86%E0%AC%9F%E0%AD%87%E0%AC%A8%E0%AD%8B%E0%AC%B2%E0%AD%8B%E0%AC%B2" title="ଆଟେନୋଲୋଲ – Odia" lang="or" hreflang="or" data-title="ଆଟେନୋଲୋଲ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Atenolol" title="Atenolol – Uzbek" lang="uz" hreflang="uz" data-title="Atenolol" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="Uzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Atenolol" title="Atenolol – Polish" lang="pl" hreflang="pl" data-title="Atenolol" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Atenolol" title="Atenolol – Portuguese" lang="pt" hreflang="pt" data-title="Atenolol" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Atenolol" title="Atenolol – Romanian" lang="ro" hreflang="ro" data-title="Atenolol" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D1%82%D0%B5%D0%BD%D0%BE%D0%BB%D0%BE%D0%BB" title="Атенолол – Russian" lang="ru" hreflang="ru" data-title="Атенолол" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sat mw-list-item"><a href="https://sat.wikipedia.org/wiki/%E1%B1%A2%E1%B1%9F%E1%B1%AD%E1%B1%9F%E1%B1%A2_%E1%B1%AA%E1%B1%9F%E1%B1%AF" title="ᱢᱟᱭᱟᱢ ᱪᱟᱯ – Santali" lang="sat" hreflang="sat" data-title="ᱢᱟᱭᱟᱢ ᱪᱟᱯ" data-language-autonym="ᱥᱟᱱᱛᱟᱲᱤ" data-language-local-name="Santali" class="interlanguage-link-target"><span>ᱥᱟᱱᱛᱟᱲᱤ</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Atenolol" title="Atenolol – Simple English" lang="en-simple" hreflang="en-simple" data-title="Atenolol" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Atenolol" title="Atenolol – Serbian" lang="sr" hreflang="sr" data-title="Atenolol" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Atenolol" title="Atenolol – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Atenolol" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Atenololi" title="Atenololi – Finnish" lang="fi" hreflang="fi" data-title="Atenololi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Atenolol" title="Atenolol – Turkish" lang="tr" hreflang="tr" data-title="Atenolol" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D1%82%D0%B5%D0%BD%D0%BE%D0%BB%D0%BE%D0%BB" title="Атенолол – Ukrainian" lang="uk" hreflang="uk" data-title="Атенолол" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Atenolol" title="Atenolol – Vietnamese" lang="vi" hreflang="vi" data-title="Atenolol" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E9%98%BF%E6%9B%BF%E6%B4%9B%E5%B0%94" title="阿替洛尔 – Chinese" lang="zh" hreflang="zh" data-title="阿替洛尔" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q411325#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Atenolol" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Atenolol" rel="discussion" title="Discuss 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class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=Esatenolol&redirect=no" class="mw-redirect" title="Esatenolol">Esatenolol</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Beta blocker medication</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Atenolol">Atenolol</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Atenolol_structure.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a0/Atenolol_structure.svg/200px-Atenolol_structure.svg.png" decoding="async" width="200" height="75" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a0/Atenolol_structure.svg/300px-Atenolol_structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a0/Atenolol_structure.svg/400px-Atenolol_structure.svg.png 2x" data-file-width="1635" data-file-height="610" /></a></span></td></tr><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Atenolol_3d_structure.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Atenolol_3d_structure.png/200px-Atenolol_3d_structure.png" decoding="async" width="200" height="62" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Atenolol_3d_structure.png/300px-Atenolol_3d_structure.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Atenolol_3d_structure.png/400px-Atenolol_3d_structure.png 2x" data-file-width="1145" data-file-height="357" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Tenormin, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">ICI-66082; ICI66082</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/atenolol.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a684031.html">a684031</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Atenolol">Atenolol</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> C</li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">Oral</a>, <a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection">intravenous</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="/wiki/Beta_blocker#Adverse_effects" title="Beta blocker">Selective</a> <a href="/wiki/Beta-1_receptor" class="mw-redirect" title="Beta-1 receptor">β<sub>1</sub> receptor</a> <a href="/wiki/Receptor_antagonist" title="Receptor antagonist">antagonist</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_C07" title="ATC code C07">C07AB03</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=C07AB03">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)</li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Boxed_warning" title="Boxed warning"><span style="border:thin solid black;">WARNING</span></a><sup id="cite_ref-FDA-AllBoxedWarnings_1-0" class="reference"><a href="#cite_note-FDA-AllBoxedWarnings-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">50–60%<sup id="cite_ref-WadworthMurdochBrogden1991_2-0" class="reference"><a href="#cite_note-WadworthMurdochBrogden1991-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HeelBrogdenSpeight1979_3-0" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">6–16%<sup id="cite_ref-TenorminLabel_4-0" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data">Minimal (~5%)<sup id="cite_ref-TenorminLabel_4-7" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BroddeKroemer2003_5-0" class="reference"><a href="#cite_note-BroddeKroemer2003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-KirchGörg1982_6-0" class="reference"><a href="#cite_note-KirchGörg1982-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Metabolite" title="Metabolite">Metabolites</a></th><td class="infobox-data">• Hydroxyatenolol<sup id="cite_ref-HeelBrogdenSpeight1979_3-1" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><br />• Atenolol glucuronide<sup id="cite_ref-HeelBrogdenSpeight1979_3-2" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Onset_of_action" title="Onset of action">Onset of action</a></th><td class="infobox-data"><a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection"><abbr title="Intravenous injection">IV</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Intravenous injection</span>: <5 minutes<sup id="cite_ref-TenorminLabel_4-1" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><br /><a href="/wiki/Oral_administration" title="Oral administration">Oral</a>: <1 hour<sup id="cite_ref-TenorminLabel_4-2" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">6–7 hours<sup id="cite_ref-TenorminLabel_4-3" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pharmacodynamics#Duration_of_action" title="Pharmacodynamics">Duration of action</a></th><td class="infobox-data">>24 hours<sup id="cite_ref-TenorminLabel_4-4" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">Oral</a>: <a href="/wiki/Urine" title="Urine">urine</a> (40–50%), <a href="/wiki/Feces" title="Feces">feces</a> (50%)<sup id="cite_ref-HeelBrogdenSpeight1979_3-3" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-5" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><br /><a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection"><abbr title="Intravenous injection">IV</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Intravenous injection</span>: urine (85–100%), feces (10%)<sup id="cite_ref-HeelBrogdenSpeight1979_3-4" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-6" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(<i>RS</i>)-2-{4-[2-Hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=29122-68-7">29122-68-7</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/2249">2249</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=548">548</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00335">DB00335</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.2162.html">2162</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/50VV3VW0TI">50VV3VW0TI</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D00235">D00235</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2904">CHEBI:2904</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL24">ChEMBL24</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID2022628">DTXSID2022628</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q411325#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.044.941">100.044.941</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q411325#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>14</sub><span title="Hydrogen">H</span><sub>22</sub><span title="Nitrogen">N</span><sub>2</sub><span title="Oxygen">O</span><sub>3</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002266341000000000♠"></span>266.341</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC%28N%29Cc1ccc%28cc1%29OCC%28O%29CNC%28C%29C">Interactive image</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chirality_(chemistry)" title="Chirality (chemistry)">Chirality</a></th><td class="infobox-data"><a href="/wiki/Racemic_mixture" title="Racemic mixture">Racemic mixture</a></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">O=C(N)Cc1ccc(cc1)OCC(O)CNC(C)C</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:METKIMKYRPQLGS-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=458476745&page2=Atenolol">(verify)</a></span></span></td></tr></tbody></table> <p><b>Atenolol</b> is a <a href="/wiki/Beta_blocker" title="Beta blocker">beta blocker</a> medication primarily used to treat <a href="/wiki/High_blood_pressure" class="mw-redirect" title="High blood pressure">high blood pressure</a> and <a href="/wiki/Angina" title="Angina">heart-associated chest pain</a>.<sup id="cite_ref-AHFS2018_7-0" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Although used to treat high blood pressure, it does not seem to improve <a href="/wiki/Mortality_rate" title="Mortality rate">mortality</a> in those with the condition.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Other uses include the prevention of <a href="/wiki/Migraines" class="mw-redirect" title="Migraines">migraines</a> and treatment of certain <a href="/wiki/Arrhythmia" title="Arrhythmia">irregular heart beats</a>.<sup id="cite_ref-AHFS2018_7-1" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BNF76_10-0" class="reference"><a href="#cite_note-BNF76-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> It is taken <a href="/wiki/Oral_administration" title="Oral administration">orally</a> (by mouth) or by <a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection">intravenous injection</a> (injection into a vein).<sup id="cite_ref-AHFS2018_7-2" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BNF76_10-1" class="reference"><a href="#cite_note-BNF76-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> It can also be used with other <a href="/wiki/Blood_pressure_medication" class="mw-redirect" title="Blood pressure medication">blood pressure medications</a>.<sup id="cite_ref-BNF76_10-2" class="reference"><a href="#cite_note-BNF76-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Common <a href="/wiki/Side_effect" title="Side effect">side effects</a> include <a href="/wiki/Fatigue_(medical)" class="mw-redirect" title="Fatigue (medical)">feeling tired</a>, <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a>, <a href="/wiki/Dizziness" title="Dizziness">dizziness</a>, <a href="/wiki/Depression_(mood)" title="Depression (mood)">depression</a>, and <a href="/wiki/Shortness_of_breath" title="Shortness of breath">shortness of breath</a>.<sup id="cite_ref-AHFS2018_7-3" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Other serious side effects include <a href="/wiki/Bronchospasm" title="Bronchospasm">bronchial spasm</a>.<sup id="cite_ref-AHFS2018_7-4" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Use is not recommended during <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a><sup id="cite_ref-AHFS2018_7-5" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and alternative drugs are preferred when <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a>.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> It works by blocking <a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub>-adrenergic receptors</a> in the <a href="/wiki/Heart" title="Heart">heart</a>, thus decreasing <a href="/wiki/Heart_rate" title="Heart rate">heart rate</a>, <a href="/wiki/Cardiac_contractility" class="mw-redirect" title="Cardiac contractility">force of heart beats</a>, and <a href="/wiki/Blood_pressure" title="Blood pressure">blood pressure</a>.<sup id="cite_ref-AHFS2018_7-6" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Atenolol was patented in 1969 and approved for medical use in 1975.<sup id="cite_ref-Fis2006_12-0" class="reference"><a href="#cite_note-Fis2006-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> It is on the <a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">World Health Organization's List of Essential Medicines</a>.<sup id="cite_ref-WHO22nd_13-0" class="reference"><a href="#cite_note-WHO22nd-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> It is available as a <a href="/wiki/Generic_medication" class="mw-redirect" title="Generic medication">generic medication</a>.<sup id="cite_ref-AHFS2018_7-7" class="reference"><a href="#cite_note-AHFS2018-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> In 2022, it was the 63rd most commonly prescribed medication in the United States, with more than 10<span class="nowrap"> </span>million prescriptions.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Atenolol is used for a number of conditions including <a href="/wiki/Hyperthyroidism" title="Hyperthyroidism">hyperthyroidism</a>,<sup id="cite_ref-Rehman_Sanchez_Shah_2021_p._16-0" class="reference"><a href="#cite_note-Rehman_Sanchez_Shah_2021_p.-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Hypertension" title="Hypertension">hypertension</a>, <a href="/wiki/Angina" title="Angina">angina</a>, <a href="/wiki/Long_QT_syndrome" title="Long QT syndrome">long QT syndrome</a>, <a href="/wiki/Acute_myocardial_infarction" class="mw-redirect" title="Acute myocardial infarction">acute myocardial infarction</a>, <a href="/wiki/Supraventricular_tachycardia" title="Supraventricular tachycardia">supraventricular tachycardia</a>, <a href="/wiki/Ventricular_tachycardia" title="Ventricular tachycardia">ventricular tachycardia</a>, and the symptoms of <a href="/wiki/Alcohol_withdrawal" class="mw-redirect" title="Alcohol withdrawal">alcohol withdrawal</a>.<sup id="cite_ref-AHFS_17-0" class="reference"><a href="#cite_note-AHFS-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p>The role for β-blockers in general in hypertension was downgraded in June 2006 in the United Kingdom, and later in the United States, as they are less appropriate than other agents such as <a href="/wiki/Angiotensin_converting_enzyme_inhibitor" class="mw-redirect" title="Angiotensin converting enzyme inhibitor">ACE inhibitors</a>, <a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">calcium channel blockers</a>, <a href="/wiki/Thiazide" title="Thiazide">thiazide</a> diuretics and <a href="/wiki/Angiotensin_receptor_blockers" class="mw-redirect" title="Angiotensin receptor blockers">angiotensin receptor blockers</a>, particularly in the elderly.<sup id="cite_ref-Cochrane2017_18-0" class="reference"><a href="#cite_note-Cochrane2017-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NHSnews_19-0" class="reference"><a href="#cite_note-NHSnews-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Cruickshank2007_20-0" class="reference"><a href="#cite_note-Cruickshank2007-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Available_forms">Available forms</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=2" title="Edit section: Available forms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Atenolol is available in the form of 25, 50, and 100<span class="nowrap"> </span>mg <a href="/wiki/Oral_administration" title="Oral administration">oral</a> <a href="/wiki/Tablet_(pharmacy)" title="Tablet (pharmacy)">tablets</a>.<sup id="cite_ref-Drugs@FDA_21-0" class="reference"><a href="#cite_note-Drugs@FDA-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-8" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is also available in the form of oral tablets containing a <a href="/wiki/Combination_drug" title="Combination drug">combination</a> of 50 or 100<span class="nowrap"> </span>mg atenolol and 50<span class="nowrap"> </span>mg <a href="/wiki/Chlortalidone" title="Chlortalidone">chlortalidone</a>.<sup id="cite_ref-Drugs@FDA_21-1" class="reference"><a href="#cite_note-Drugs@FDA-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Atenolol was previously available in a 0.5<span class="nowrap"> </span>mg/mL solution for <a href="/wiki/Injection_(medicine)" title="Injection (medicine)">injection</a> as well, but this formulation was discontinued.<sup id="cite_ref-Drugs@FDA_21-2" class="reference"><a href="#cite_note-Drugs@FDA-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Side_effects">Side effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=3" title="Edit section: Side effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Beta_blocker" title="Beta blocker">Beta blocker</a></div> <p>Hypertension treated with a β-blocker such as atenolol, alone or in conjunction with a thiazide diuretic, is associated with a higher incidence of new onset type 2 diabetes mellitus compared to those treated with an ACE inhibitor or angiotensin receptor blocker.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>β-blockers, of which atenolol is mainly studied, provides weaker protection against <a href="/wiki/Stroke" title="Stroke">stroke</a> and mortality in patients over 60 years old compared to other antihypertensive medications.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Cochrane2017_18-1" class="reference"><a href="#cite_note-Cochrane2017-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Diuretic" title="Diuretic">Diuretics</a> may be associated with better cardiovascular and cerebrovascular outcomes than β-blockers in the elderly.<sup id="cite_ref-pmid15530629_27-0" class="reference"><a href="#cite_note-pmid15530629-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p><p>Rarely, atenolol has been associated with induction of acute <a href="/wiki/Delirium" title="Delirium">delirium</a>.<sup id="cite_ref-KellerFrishman2003_28-0" class="reference"><a href="#cite_note-KellerFrishman2003-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-WadworthMurdochBrogden1991_2-1" class="reference"><a href="#cite_note-WadworthMurdochBrogden1991-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Arber1988_29-0" class="reference"><a href="#cite_note-Arber1988-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Overdose">Overdose</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=4" title="Edit section: Overdose"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Symptoms of <a href="/wiki/Overdose" class="mw-redirect" title="Overdose">overdose</a> are due to excessive pharmacodynamic actions on β<sub>1</sub> and also β<sub>2</sub>-receptors. These include <a href="/wiki/Bradycardia" title="Bradycardia">bradycardia</a> (slow heartbeat), severe <a href="/wiki/Hypotension" title="Hypotension">hypotension</a> with <a href="/wiki/Shock_(circulatory)" title="Shock (circulatory)">shock</a>, acute <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a>, <a href="/wiki/Hypoglycemia" title="Hypoglycemia">hypoglycemia</a> and bronchospastic reactions. Treatment is largely symptomatic. Hospitalization and intensive monitoring is indicated. <a href="/wiki/Activated_charcoal" class="mw-redirect" title="Activated charcoal">Activated charcoal</a> is useful to absorb the drug. <a href="/wiki/Atropine" title="Atropine">Atropine</a> will counteract bradycardia, <a href="/wiki/Glucagon" title="Glucagon">glucagon</a> helps with hypoglycemia, <a href="/wiki/Dobutamine" title="Dobutamine">dobutamine</a> can be given against hypotension and the inhalation of a β<sub>2</sub>-mimetic such as <a href="/wiki/Hexoprenalin" class="mw-redirect" title="Hexoprenalin">hexoprenalin</a> or <a href="/wiki/Salbutamol" title="Salbutamol">salbutamol</a> will terminate bronchospasms. Blood or plasma atenolol concentrations may be measured to confirm a diagnosis of poisoning in hospitalized patients or to assist in a medicolegal death investigation. Plasma levels are usually less than 3 mg/L during therapeutic administration, but can range from 3–30 mg/L in overdose victims.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=5" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Drug_interaction" title="Drug interaction">Interactions</a> with atenolol include <a href="/wiki/Monoamine-depleting_agent" title="Monoamine-depleting agent">catecholamine-depleting drugs</a> like <a href="/wiki/Reserpine" title="Reserpine">reserpine</a>, <a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">calcium channel blockers</a>, <a href="/wiki/Disopyramide" title="Disopyramide">disopyramide</a>, <a href="/wiki/Amiodarone" title="Amiodarone">amiodarone</a>, <a href="/wiki/Clonidine" title="Clonidine">clonidine</a>, <a href="/wiki/Prostaglandin_inhibitor" class="mw-redirect" title="Prostaglandin inhibitor">prostaglandin synthase inhibitors</a> like <a href="/wiki/Indomethacin" class="mw-redirect" title="Indomethacin">indomethacin</a>, and <a href="/wiki/Cardiac_glycoside" title="Cardiac glycoside">digitalis glycosides</a>.<sup id="cite_ref-Atenolol-Label_32-0" class="reference"><a href="#cite_note-Atenolol-Label-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> Most of these interactions involve either additive cardiovascular effects or reduction of atenolol's effects.<sup id="cite_ref-Atenolol-Label_32-1" class="reference"><a href="#cite_note-Atenolol-Label-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p><p>Atenolol is mainly <a href="/wiki/Elimination_(pharmacology)" title="Elimination (pharmacology)">eliminated</a> <a href="/wiki/Kidney" title="Kidney">renally</a> without being <a href="/wiki/Metabolism" title="Metabolism">metabolized</a> by the <a href="/wiki/Liver" title="Liver">liver</a> or by <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">cytochrome P450</a> <a href="/wiki/Enzyme" title="Enzyme">enzymes</a>.<sup id="cite_ref-Atenolol-Label_32-2" class="reference"><a href="#cite_note-Atenolol-Label-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BroddeKroemer2003_5-1" class="reference"><a href="#cite_note-BroddeKroemer2003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Scheen2011_33-0" class="reference"><a href="#cite_note-Scheen2011-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> As a result, it has little or no potential for cytochrome P450-related drug interactions, for instance with <a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibitors</a> and <a href="/wiki/Enzyme_inducer" title="Enzyme inducer">inducers</a> of these enzymes.<sup id="cite_ref-BroddeKroemer2003_5-2" class="reference"><a href="#cite_note-BroddeKroemer2003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Scheen2011_33-1" class="reference"><a href="#cite_note-Scheen2011-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> Accordingly, the broad/<a href="/wiki/Binding_selectivity" title="Binding selectivity">non-selective</a> cytochrome P450 inhibitor <a href="/wiki/Cimetidine" title="Cimetidine">cimetidine</a> had no effect on atenolol levels, whereas cimetidine has been found to significantly increase <a href="/wiki/Metoprolol" title="Metoprolol">metoprolol</a> and <a href="/wiki/Propranolol" title="Propranolol">propranolol</a> levels.<sup id="cite_ref-BroddeKroemer2003_5-3" class="reference"><a href="#cite_note-BroddeKroemer2003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Beta blockers like atenolol can reduce or block the <a href="/wiki/Cardiovascular" class="mw-redirect" title="Cardiovascular">cardiovascular</a> effects of <a href="/wiki/Sympathomimetic" class="mw-redirect" title="Sympathomimetic">sympathomimetics</a> and <a href="/wiki/Amphetamine-type_stimulant" class="mw-redirect" title="Amphetamine-type stimulant">amphetamines</a>, such as <a href="/wiki/Hypertension" title="Hypertension">hypertension</a> and <a href="/wiki/Tachycardia" title="Tachycardia">tachycardia</a>.<sup id="cite_ref-RichardsAlbertsonDerlet2015_34-0" class="reference"><a href="#cite_note-RichardsAlbertsonDerlet2015-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-VetterEliaErickson2008_35-0" class="reference"><a href="#cite_note-VetterEliaErickson2008-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SchindlerZhengTella1992_36-0" class="reference"><a href="#cite_note-SchindlerZhengTella1992-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MoresCampiaNavarra1999_37-0" class="reference"><a href="#cite_note-MoresCampiaNavarra1999-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HassanGunaidElKhally2005_38-0" class="reference"><a href="#cite_note-HassanGunaidElKhally2005-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OConnellGross1990_39-0" class="reference"><a href="#cite_note-OConnellGross1990-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OConnellGross1991_40-0" class="reference"><a href="#cite_note-OConnellGross1991-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p><p>Atenolol has been found to be safe in combination with the <a href="/wiki/Binding_selectivity" title="Binding selectivity">non-selective</a> <a href="/wiki/Monoamine_oxidase_inhibitor" title="Monoamine oxidase inhibitor">monoamine oxidase inhibitor</a> (MAOI) <a href="/wiki/Phenelzine" title="Phenelzine">phenelzine</a> and actually improved <a href="/wiki/Orthostatic_hypotension" title="Orthostatic hypotension">orthostatic hypotension</a> and <a href="/wiki/Hypertension" title="Hypertension">hypertensive</a> reactions with phenelzine.<sup id="cite_ref-Balon1998_41-0" class="reference"><a href="#cite_note-Balon1998-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-OBrienOyebode2003_42-0" class="reference"><a href="#cite_note-OBrienOyebode2003-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MerikangasMerikangas1995_43-0" class="reference"><a href="#cite_note-MerikangasMerikangas1995-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> However, more research is still needed to assess whether addition of a beta blocker like atenolol to MAOI therapy is safe and effective for improving orthostatic hypotension with MAOIs.<sup id="cite_ref-Balon1998_41-1" class="reference"><a href="#cite_note-Balon1998-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MerikangasMerikangas1995_43-1" class="reference"><a href="#cite_note-MerikangasMerikangas1995-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=6" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Pharmacodynamics">Pharmacodynamics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=7" title="Edit section: Pharmacodynamics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Atenolol is a <a href="/wiki/Beta_blocker" title="Beta blocker">beta blocker</a>; that is, an <a href="/wiki/Receptor_antagonist" title="Receptor antagonist">antagonist</a> of the <a href="/wiki/%CE%92-adrenergic_receptor" class="mw-redirect" title="Β-adrenergic receptor">β-adrenergic receptors</a>.<sup id="cite_ref-pmid33572109_44-0" class="reference"><a href="#cite_note-pmid33572109-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-9" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> It is specifically a <a href="/wiki/Binding_selectivity" title="Binding selectivity">selective</a> antagonist of the <a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub>-adrenergic receptor</a> with no <a href="/wiki/Intrinsic_sympathomimetic_activity" class="mw-redirect" title="Intrinsic sympathomimetic activity">intrinsic sympathomimetic activity</a> (i.e., <a href="/wiki/Partial_agonist" title="Partial agonist">partial agonist</a> activity) or <a href="/wiki/Membrane_stabilizing_effect" title="Membrane stabilizing effect">membrane-stabilizing activity</a>.<sup id="cite_ref-pmid33572109_44-1" class="reference"><a href="#cite_note-pmid33572109-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-10" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> However, the preferential action of atenolol is not absolute, and at high doses. it can also block <a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub>-adrenergic receptors</a>.<sup id="cite_ref-TenorminLabel_4-11" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>Beta-blocking effects of atenolol include reduction in <a href="/wiki/Resting_heart_rate" class="mw-redirect" title="Resting heart rate">resting</a> and <a href="/wiki/Exercise" title="Exercise">exercise</a> <a href="/wiki/Heart_rate" title="Heart rate">heart rate</a> and <a href="/wiki/Cardiac_output" title="Cardiac output">cardiac output</a>, reduction of <a href="/wiki/Systolic_blood_pressure" class="mw-redirect" title="Systolic blood pressure">systolic</a> and <a href="/wiki/Diastolic_blood_pressure" class="mw-redirect" title="Diastolic blood pressure">diastolic blood pressure</a> at rest and with exercise, inhibition of <a href="/wiki/Tachycardia" title="Tachycardia">tachycardia</a> induced by <a href="/wiki/Isoproterenol" class="mw-redirect" title="Isoproterenol">isoproterenol</a> (a non-selective β-adrenergic receptor <a href="/wiki/Agonist" title="Agonist">agonist</a>), and reduction of <a href="/wiki/Reflex_tachycardia" class="mw-redirect" title="Reflex tachycardia">reflex</a> orthostatic tachycardia.<sup id="cite_ref-TenorminLabel_4-12" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>The beta-blocking effects of atenolol, as measured by reduction of exercise-related tachycardia, are apparent within 1<span class="nowrap"> </span>hour and are maximal within 2 to 4<span class="nowrap"> </span>hours following a single oral dose.<sup id="cite_ref-TenorminLabel_4-13" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> The general effects of atenolol, including beta-blocking and <a href="/wiki/Antihypertensive" title="Antihypertensive">antihypertensive</a> effects, last for at least 24<span class="nowrap"> </span>hours following <a href="/wiki/Oral_administration" title="Oral administration">oral</a> doses of 50 or 100<span class="nowrap"> </span>mg.<sup id="cite_ref-TenorminLabel_4-14" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> With intravenous administration, maximal reduction in exercise-related tachycardia occurs within 5<span class="nowrap"> </span>minutes and following a single 10<span class="nowrap"> </span>mg dose has dissipated within 12<span class="nowrap"> </span>hours.<sup id="cite_ref-TenorminLabel_4-15" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Duration_of_action" class="mw-redirect" title="Duration of action">duration of action</a> of atenolol is dose-related and is correlated with circulating levels of atenolol.<sup id="cite_ref-TenorminLabel_4-16" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=8" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading4"><h4 id="Absorption">Absorption</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=9" title="Edit section: Absorption"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Oral_administration" title="Oral administration">oral</a> <a href="/wiki/Bioavailability" title="Bioavailability">bioavailability</a> of atenolol is approximately 50 to 60%.<sup id="cite_ref-WadworthMurdochBrogden1991_2-2" class="reference"><a href="#cite_note-WadworthMurdochBrogden1991-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HeelBrogdenSpeight1979_3-5" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Absorption_(pharmacokinetics)" class="mw-redirect" title="Absorption (pharmacokinetics)">absorption</a> of atenolol with oral administration is rapid and consistent but is incomplete.<sup id="cite_ref-TenorminLabel_4-17" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> About 50% of an oral dose of atenolol is absorbed from the <a href="/wiki/Intestine" class="mw-redirect" title="Intestine">intestines</a>, with the rest <a href="/wiki/Excretion" title="Excretion">excreted</a> in <a href="/wiki/Feces" title="Feces">feces</a>.<sup id="cite_ref-TenorminLabel_4-18" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Cmax_(pharmacology)" title="Cmax (pharmacology)">Maximal concentrations</a> of atenolol occur 2 to 4<span class="nowrap"> </span>hours following an oral dose, whereas peak concentrations occur within 5<span class="nowrap"> </span>minutes with <a href="/wiki/Intravenous_administration" class="mw-redirect" title="Intravenous administration">intravenous administration</a>.<sup id="cite_ref-TenorminLabel_4-19" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Pharmacokinetic" class="mw-redirect" title="Pharmacokinetic">pharmacokinetic</a> profile of atenolol results in it having relatively consistent plasma drug levels with about 4-fold variation between individuals.<sup id="cite_ref-TenorminLabel_4-20" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Distribution">Distribution</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=10" title="Edit section: Distribution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">plasma protein binding</a> of atenolol is 6 to 16%.<sup id="cite_ref-TenorminLabel_4-21" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>Atenolol is classified as a beta blocker with low <a href="/wiki/Lipophilicity" title="Lipophilicity">lipophilicity</a> and hence lower potential for crossing the <a href="/wiki/Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood–brain barrier</a> and entering the brain.<sup id="cite_ref-pmid33572109_44-2" class="reference"><a href="#cite_note-pmid33572109-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> This in turn may result in fewer effects in the <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a> as well as a lower risk of <a href="/wiki/Neuropsychiatric" class="mw-redirect" title="Neuropsychiatric">neuropsychiatric</a> side effects.<sup id="cite_ref-pmid33572109_44-3" class="reference"><a href="#cite_note-pmid33572109-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> Only small amounts of atenolol are said to enter the brain.<sup id="cite_ref-WadworthMurdochBrogden1991_2-3" class="reference"><a href="#cite_note-WadworthMurdochBrogden1991-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HeelBrogdenSpeight1979_3-6" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The brain-to-blood ratio of atenolol was 0.2 : 1 in one study, whereas the ratio for propranolol was 33 : 1 in the same study.<sup id="cite_ref-HeelBrogdenSpeight1979_3-7" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Metabolism">Metabolism</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=11" title="Edit section: Metabolism"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Atenolol undergoes minimal or negligible <a href="/wiki/Drug_metabolism" title="Drug metabolism">metabolism</a> by the <a href="/wiki/Liver" title="Liver">liver</a>.<sup id="cite_ref-TenorminLabel_4-22" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BroddeKroemer2003_5-4" class="reference"><a href="#cite_note-BroddeKroemer2003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It has been estimated that about 5% of atenolol is metabolized.<sup id="cite_ref-KirchGörg1982_6-1" class="reference"><a href="#cite_note-KirchGörg1982-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> This is in contrast to other beta blockers like <a href="/wiki/Propranolol" title="Propranolol">propranolol</a> and <a href="/wiki/Metoprolol" title="Metoprolol">metoprolol</a>, but is similar to <a href="/wiki/Nadolol" title="Nadolol">nadolol</a>.<sup id="cite_ref-TenorminLabel_4-23" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> In accordance with its lack of hepatic metabolism, the pharmacokinetics of atenolol are not altered in <a href="/wiki/Hepatic_impairment" class="mw-redirect" title="Hepatic impairment">hepatic impairment</a>, unlike the case of propranolol.<sup id="cite_ref-BroddeKroemer2003_5-5" class="reference"><a href="#cite_note-BroddeKroemer2003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Two <a href="/wiki/Metabolite" title="Metabolite">metabolites</a> of atenolol have been identified: hydroxyatenolol and atenolol glucuronide.<sup id="cite_ref-WadworthMurdochBrogden1991_2-4" class="reference"><a href="#cite_note-WadworthMurdochBrogden1991-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> It has been said that it is unknown if these metabolites are active.<sup id="cite_ref-WadworthMurdochBrogden1991_2-5" class="reference"><a href="#cite_note-WadworthMurdochBrogden1991-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> However, another source stated that hydroxyatenolol has one-tenth the beta-blocking activity of atenolol.<sup id="cite_ref-HeelBrogdenSpeight1979_3-8" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Elimination">Elimination</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=12" title="Edit section: Elimination"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Instead of by hepatic metabolism, atenolol is <a href="/wiki/Elimination_(pharmacology)" title="Elimination (pharmacology)">eliminated</a> from the blood mainly via <a href="/wiki/Kidney" title="Kidney">renal</a> <a href="/wiki/Excretion" title="Excretion">excretion</a>.<sup id="cite_ref-TenorminLabel_4-24" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Atenolol is excreted about 40 to 50% in <a href="/wiki/Urine" title="Urine">urine</a> and 50% in <a href="/wiki/Feces" title="Feces">feces</a> with oral administration.<sup id="cite_ref-HeelBrogdenSpeight1979_3-9" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-25" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Conversely, it is excreted 85 to 100% in urine unchanged and 10% in feces with intravenous administration.<sup id="cite_ref-HeelBrogdenSpeight1979_3-10" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TenorminLabel_4-26" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Only very small amounts of hydroxyatenolol and atenolol glucuronide are found in urine with atenolol.<sup id="cite_ref-HeelBrogdenSpeight1979_3-11" class="reference"><a href="#cite_note-HeelBrogdenSpeight1979-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>The <a href="/wiki/Elimination_half-life" class="mw-redirect" title="Elimination half-life">elimination half-life</a> of atenolol is about 6 to 7<span class="nowrap"> </span>hours.<sup id="cite_ref-TenorminLabel_4-27" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> The half-life of atenolol does not change with continuous administration.<sup id="cite_ref-TenorminLabel_4-28" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> With intravenous administration, atenolol levels rapidly decline (5- to 10-fold) during the first 7<span class="nowrap"> </span>hours and thereafter decline at a rate similar to that with oral administration.<sup id="cite_ref-TenorminLabel_4-29" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>The elimination of atenolol is slowed in <a href="/wiki/Renal_impairment" class="mw-redirect" title="Renal impairment">renal impairment</a>, with the elimination rate being closely related to the <a href="/wiki/Glomerular_filtration_rate" title="Glomerular filtration rate">glomerular filtration rate</a> (GFR) and with significant accumulation occurring when the <a href="/wiki/Creatinine" title="Creatinine">creatinine</a> <a href="/wiki/Clearance_(pharmacology)" title="Clearance (pharmacology)">clearance</a> rate is under 35<span class="nowrap"> </span>mL/min/1.73<span class="nowrap"> </span>m<sup>2</sup>.<sup id="cite_ref-TenorminLabel_4-30" class="reference"><a href="#cite_note-TenorminLabel-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> At a GFR of less than 10<span class="nowrap"> </span>mL/min, the half-life of atenolol increases up to 36<span class="nowrap"> </span>hours.<sup id="cite_ref-KirchGörg1982_6-2" class="reference"><a href="#cite_note-KirchGörg1982-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Chemistry">Chemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=13" title="Edit section: Chemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Atenolol is a <a href="/wiki/Substituted_phenethylamine" title="Substituted phenethylamine">substituted phenethylamine</a> <a href="/wiki/Chemical_derivative" class="mw-redirect" title="Chemical derivative">derivative</a>.<sup id="cite_ref-PubChem_45-0" class="reference"><a href="#cite_note-PubChem-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> It is specifically <a href="/wiki/%CE%92-phenylethylamine" class="mw-redirect" title="Β-phenylethylamine">β-phenylethylamine</a> with an α-keto <a href="/wiki/Chemical_substituent" class="mw-redirect" title="Chemical substituent">substitution</a> and a 4- substitution on the <a href="/wiki/Phenyl_ring" class="mw-redirect" title="Phenyl ring">phenyl ring</a>.<sup id="cite_ref-PubChem_45-1" class="reference"><a href="#cite_note-PubChem-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p><p>The experimental <a href="/wiki/Partition_coefficient" title="Partition coefficient">log P</a> of atenolol is 0.16 and its predicted log P ranges from −0.03 to 0.57.<sup id="cite_ref-PubChem_45-2" class="reference"><a href="#cite_note-PubChem-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DrugBank_46-0" class="reference"><a href="#cite_note-DrugBank-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ChemSpider_47-0" class="reference"><a href="#cite_note-ChemSpider-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p><p>Atenolol is closely <a href="/wiki/Structural_analog" title="Structural analog">structurally related</a> to metoprolol and certain other beta blockers. It is also structurally related to the <a href="/wiki/Catecholamine" title="Catecholamine">catecholamine</a> <a href="/wiki/Neurotransmitter" title="Neurotransmitter">neurotransmitters</a> <a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">epinephrine</a> (adrenaline) and <a href="/wiki/Norepinephrine" title="Norepinephrine">norepinephrine</a> (noradrenaline). </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=14" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Changing_medical_practices">Changing medical practices</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=15" title="Edit section: Changing medical practices"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Atenolol has been given as an example of how slow healthcare providers are to change their prescribing practices in the face of <a href="/wiki/Evidence-based_medicine" title="Evidence-based medicine">medical evidence</a> that indicates that a drug is not as effective as others in treating some conditions.<sup id="cite_ref-:0_48-0" class="reference"><a href="#cite_note-:0-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> In 2012, 33.8 million prescriptions were written to American patients for this drug.<sup id="cite_ref-:0_48-1" class="reference"><a href="#cite_note-:0-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> In 2014, it was in the top (most common) 1% of drugs prescribed to Medicare patients.<sup id="cite_ref-:0_48-2" class="reference"><a href="#cite_note-:0-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> Although the number of prescriptions has been declining steadily since limited evidence articles contesting its efficacy was published, it has been estimated that it would take 20 years for doctors to stop prescribing it for hypertension.<sup id="cite_ref-:0_48-3" class="reference"><a href="#cite_note-:0-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> Despite its diminished efficacy when compared to newer <a href="/wiki/Antihypertensive_drug" class="mw-redirect" title="Antihypertensive drug">antihypertensive drugs</a>, atenolol and other <a href="/wiki/Beta_blocker" title="Beta blocker">beta blockers</a> are still a relevant clinical choice for treating some conditions, since <a href="/wiki/Beta_blocker" title="Beta blocker">beta blockers</a> are a diverse group of medicines with different properties that still requires further research.<sup id="cite_ref-Cochrane2017_18-2" class="reference"><a href="#cite_note-Cochrane2017-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> As consequence, reasons for the popularity of beta blockers cannot be fully attributed to a slow healthcare system – <a href="/wiki/Patient_compliance" class="mw-redirect" title="Patient compliance">patient compliance</a> factor, such as treatment cost and duration, also affect adherence and popularity of therapy.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Atenolol&action=edit&section=16" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-FDA-AllBoxedWarnings-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-FDA-AllBoxedWarnings_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802">"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"</a>. <i>nctr-crs.fda.gov</i>. <a href="/wiki/FDA" class="mw-redirect" title="FDA">FDA</a><span class="reference-accessdate">. Retrieved <span class="nowrap">22 October</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=nctr-crs.fda.gov&rft.atitle=FDA-sourced+list+of+all+drugs+with+black+box+warnings+%28Use+Download+Full+Results+and+View+Query+links.%29&rft_id=https%3A%2F%2Fnctr-crs.fda.gov%2Ffdalabel%2Fui%2Fspl-summaries%2Fcriteria%2F343802&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-WadworthMurdochBrogden1991-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-WadworthMurdochBrogden1991_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-WadworthMurdochBrogden1991_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-WadworthMurdochBrogden1991_2-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-WadworthMurdochBrogden1991_2-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-WadworthMurdochBrogden1991_2-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-WadworthMurdochBrogden1991_2-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWadworthMurdochBrogden1991" class="citation journal cs1">Wadworth AN, Murdoch D, Brogden RN (September 1991). "Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders". <i>Drugs</i>. <b>42</b> (3): 468–510. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F00003495-199142030-00007">10.2165/00003495-199142030-00007</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1720383">1720383</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Atenolol.+A+reappraisal+of+its+pharmacological+properties+and+therapeutic+use+in+cardiovascular+disorders&rft.volume=42&rft.issue=3&rft.pages=468-510&rft.date=1991-09&rft_id=info%3Adoi%2F10.2165%2F00003495-199142030-00007&rft_id=info%3Apmid%2F1720383&rft.aulast=Wadworth&rft.aufirst=AN&rft.au=Murdoch%2C+D&rft.au=Brogden%2C+RN&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-HeelBrogdenSpeight1979-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-HeelBrogdenSpeight1979_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-HeelBrogdenSpeight1979_3-11"><sup><i><b>l</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHeelBrogdenSpeightAvery1979" class="citation journal cs1">Heel RC, Brogden RN, Speight TM, Avery GS (June 1979). "Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension". <i>Drugs</i>. <b>17</b> (6): 425–460. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F00003495-197917060-00001">10.2165/00003495-197917060-00001</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/38096">38096</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Atenolol%3A+a+review+of+its+pharmacological+properties+and+therapeutic+efficacy+in+angina+pectoris+and+hypertension&rft.volume=17&rft.issue=6&rft.pages=425-460&rft.date=1979-06&rft_id=info%3Adoi%2F10.2165%2F00003495-197917060-00001&rft_id=info%3Apmid%2F38096&rft.aulast=Heel&rft.aufirst=RC&rft.au=Brogden%2C+RN&rft.au=Speight%2C+TM&rft.au=Avery%2C+GS&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-TenorminLabel-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-TenorminLabel_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-17"><sup><i><b>r</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-18"><sup><i><b>s</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-19"><sup><i><b>t</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-20"><sup><i><b>u</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-21"><sup><i><b>v</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-22"><sup><i><b>w</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-23"><sup><i><b>x</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-24"><sup><i><b>y</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-25"><sup><i><b>z</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-26"><sup><i><b>aa</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-27"><sup><i><b>ab</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-28"><sup><i><b>ac</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-29"><sup><i><b>ad</b></i></sup></a> <a href="#cite_ref-TenorminLabel_4-30"><sup><i><b>ae</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=746db603-a6e1-4dc3-c2d8-92314419098c">"DailyMed - TENORMIN- atenolol tablet"</a>. <i>DailyMed</i>. 30 June 2021. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220127140640/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=746db603-a6e1-4dc3-c2d8-92314419098c">Archived</a> from the original on 27 January 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">20 November</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=DailyMed+-+TENORMIN-+atenolol+tablet&rft.date=2021-06-30&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3D746db603-a6e1-4dc3-c2d8-92314419098c&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-BroddeKroemer2003-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-BroddeKroemer2003_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-BroddeKroemer2003_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-BroddeKroemer2003_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-BroddeKroemer2003_5-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-BroddeKroemer2003_5-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-BroddeKroemer2003_5-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBroddeKroemer2003" class="citation journal cs1">Brodde OE, Kroemer HK (2003). "Drug-drug interactions of beta-adrenoceptor blockers". <i>Arzneimittelforschung</i>. <b>53</b> (12): 814–822. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1055%2Fs-0031-1299835">10.1055/s-0031-1299835</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14732961">14732961</a>. <q>Atenolol is only minimally, if at all, metabolized and renally excreted in mostly unchanged form; thus an interaction with drugs that interfere with the hepatic metabolism is not to be expected. It is also very unlikely that the genetic polymorphisms of the CYP-family might affect the pharmacokinetics of atenolol. In fact it has been shown that plasma concentrations of nonmetabolized atenolol was not significantly different between "extensive" and "poor debrisoquine metabolizers" – in contrast to the plasma concentrations of metoprolol that were significantly increased in "poor metabolizers" (Dayer et al. 1985, Lewis et al. 1985). Furthermore, in healthy volunteers cimetidine (CAS 70059- 30-2) did not affect plasma concentrations of atenolol but significantly increased plasma concentrations of metoprolol or propranolol (Kirch et al. 1981).</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arzneimittelforschung&rft.atitle=Drug-drug+interactions+of+beta-adrenoceptor+blockers&rft.volume=53&rft.issue=12&rft.pages=814-822&rft.date=2003&rft_id=info%3Adoi%2F10.1055%2Fs-0031-1299835&rft_id=info%3Apmid%2F14732961&rft.aulast=Brodde&rft.aufirst=OE&rft.au=Kroemer%2C+HK&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-KirchGörg1982-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-KirchGörg1982_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-KirchGörg1982_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-KirchGörg1982_6-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKirchGörg1982" class="citation journal cs1">Kirch W, Görg KG (1982). "Clinical pharmacokinetics of atenolol--a review". <i>Eur J Drug Metab Pharmacokinet</i>. <b>7</b> (2): 81–91. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2FBF03188723">10.1007/BF03188723</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/6749509">6749509</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Eur+J+Drug+Metab+Pharmacokinet&rft.atitle=Clinical+pharmacokinetics+of+atenolol--a+review&rft.volume=7&rft.issue=2&rft.pages=81-91&rft.date=1982&rft_id=info%3Adoi%2F10.1007%2FBF03188723&rft_id=info%3Apmid%2F6749509&rft.aulast=Kirch&rft.aufirst=W&rft.au=G%C3%B6rg%2C+KG&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-AHFS2018-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-AHFS2018_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-AHFS2018_7-7"><sup><i><b>h</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/atenolol.html">"Atenolol Monograph for Professionals"</a>. <i>Drugs.com</i>. AHFS. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190418043029/https://www.drugs.com/monograph/atenolol.html">Archived</a> from the original on 18 April 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">23 December</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Atenolol+Monograph+for+Professionals&rft_id=https%3A%2F%2Fwww.drugs.com%2Fmonograph%2Fatenolol.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTomiyamaYamashina2014" class="citation journal cs1">Tomiyama H, Yamashina A (2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941231">"Beta-Blockers in the Management of Hypertension and/or Chronic Kidney Disease"</a>. <i>International Journal of Hypertension</i>. <b>2014</b>: 919256. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1155%2F2014%2F919256">10.1155/2014/919256</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941231">3941231</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24672712">24672712</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Hypertension&rft.atitle=Beta-Blockers+in+the+Management+of+Hypertension+and%2For+Chronic+Kidney+Disease&rft.volume=2014&rft.pages=919256&rft.date=2014&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3941231%23id-name%3DPMC&rft_id=info%3Apmid%2F24672712&rft_id=info%3Adoi%2F10.1155%2F2014%2F919256&rft.aulast=Tomiyama&rft.aufirst=H&rft.au=Yamashina%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3941231&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDiNicolantonioFaresNiaziChatterjee2015" class="citation journal cs1">DiNicolantonio JJ, Fares H, Niazi AK, Chatterjee S, D'Ascenzo F, Cerrato E, et al. (2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371808">"β-Blockers in hypertension, diabetes, heart failure and acute myocardial infarction: a review of the literature"</a>. <i>Open Heart</i>. <b>2</b> (1): e000230. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fopenhrt-2014-000230">10.1136/openhrt-2014-000230</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371808">4371808</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25821584">25821584</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Open+Heart&rft.atitle=%CE%B2-Blockers+in+hypertension%2C+diabetes%2C+heart+failure+and+acute+myocardial+infarction%3A+a+review+of+the+literature&rft.volume=2&rft.issue=1&rft.pages=e000230&rft.date=2015&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4371808%23id-name%3DPMC&rft_id=info%3Apmid%2F25821584&rft_id=info%3Adoi%2F10.1136%2Fopenhrt-2014-000230&rft.aulast=DiNicolantonio&rft.aufirst=JJ&rft.au=Fares%2C+H&rft.au=Niazi%2C+AK&rft.au=Chatterjee%2C+S&rft.au=D%27Ascenzo%2C+F&rft.au=Cerrato%2C+E&rft.au=Biondi-Zoccai%2C+G&rft.au=Lavie%2C+CJ&rft.au=Bell%2C+DS&rft.au=O%27Keefe%2C+JH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4371808&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-BNF76-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-BNF76_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-BNF76_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-BNF76_10-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><i>British national formulary : BNF 76</i> (76 ed.). Pharmaceutical Press. 2018. pp. 151–153. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780857113382" title="Special:BookSources/9780857113382"><bdi>9780857113382</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=British+national+formulary+%3A+BNF+76&rft.pages=151-153&rft.edition=76&rft.pub=Pharmaceutical+Press&rft.date=2018&rft.isbn=9780857113382&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/breastfeeding/atenolol.html">"Atenolol use while Breastfeeding"</a>. <i>Drugs.com</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20181223121344/https://www.drugs.com/breastfeeding/atenolol.html">Archived</a> from the original on 23 December 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">23 December</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Atenolol+use+while+Breastfeeding&rft_id=https%3A%2F%2Fwww.drugs.com%2Fbreastfeeding%2Fatenolol.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Fis2006-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-Fis2006_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFischerGanellin2006" class="citation book cs1">Fischer J, Ganellin CR (2006). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA461"><i>Analogue-based Drug Discovery</i></a>. John Wiley & Sons. p. 461. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783527607495" title="Special:BookSources/9783527607495"><bdi>9783527607495</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Analogue-based+Drug+Discovery&rft.pages=461&rft.pub=John+Wiley+%26+Sons&rft.date=2006&rft.isbn=9783527607495&rft.aulast=Fischer&rft.aufirst=J&rft.au=Ganellin%2C+CR&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DFjKfqkaKkAAC%26pg%3DPA461&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-WHO22nd-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-WHO22nd_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWorld_Health_Organization2021" class="citation book cs1"><a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (2021). <i>World Health Organization model list of essential medicines: 22nd list (2021)</i>. Geneva: World Health Organization. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/10665%2F345533">10665/345533</a></span>. WHO/MHP/HPS/EML/2021.02.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=World+Health+Organization+model+list+of+essential+medicines%3A+22nd+list+%282021%29&rft.place=Geneva&rft.pub=World+Health+Organization&rft.date=2021&rft_id=info%3Ahdl%2F10665%2F345533&rft.au=World+Health+Organization&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Top300Drugs.aspx">"The Top 300 of 2022"</a>. <i>ClinCalc</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx">Archived</a> from the original on 30 August 2024<span class="reference-accessdate">. Retrieved <span class="nowrap">30 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinCalc&rft.atitle=The+Top+300+of+2022&rft_id=https%3A%2F%2Fclincalc.com%2FDrugStats%2FTop300Drugs.aspx&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Drugs/Atenolol">"Atenolol Drug Usage Statistics, United States, 2013 - 2022"</a>. <i>ClinCalc</i><span class="reference-accessdate">. Retrieved <span class="nowrap">30 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinCalc&rft.atitle=Atenolol+Drug+Usage+Statistics%2C+United+States%2C+2013+-+2022&rft_id=https%3A%2F%2Fclincalc.com%2FDrugStats%2FDrugs%2FAtenolol&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Rehman_Sanchez_Shah_2021_p.-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-Rehman_Sanchez_Shah_2021_p._16-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRehmanSanchezShah2021" class="citation book cs1">Rehman B, Sanchez DP, Shah S (2021). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/books/NBK539844/">"Atenolol"</a>. <i>StatPearls</i>. Treasure Island (FL): StatPearls Publishing. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30969666">30969666</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20221010053047/https://www.ncbi.nlm.nih.gov/books/NBK539844/">Archived</a> from the original on 10 October 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">5 September</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Atenolol&rft.btitle=StatPearls&rft.place=Treasure+Island+%28FL%29&rft.pub=StatPearls+Publishing&rft.date=2021&rft_id=info%3Apmid%2F30969666&rft.aulast=Rehman&rft.aufirst=B&rft.au=Sanchez%2C+DP&rft.au=Shah%2C+S&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fbooks%2FNBK539844%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-AHFS-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-AHFS_17-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/atenolol.html">"Atenolol"</a>. <i>The American Society of Health-System Pharmacists</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190418043029/https://www.drugs.com/monograph/atenolol.html">Archived</a> from the original on 18 April 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">8 May</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=The+American+Society+of+Health-System+Pharmacists&rft.atitle=Atenolol&rft_id=https%3A%2F%2Fwww.drugs.com%2Fmonograph%2Fatenolol.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Cochrane2017-18"><span class="mw-cite-backlink">^ <a href="#cite_ref-Cochrane2017_18-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Cochrane2017_18-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Cochrane2017_18-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWiysongeBradleyVolminkMayosi2017" class="citation journal cs1">Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH (January 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369873">"Beta-blockers for hypertension"</a>. <i>The Cochrane Database of Systematic Reviews</i>. <b>1</b> (1): CD002003. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F14651858.CD002003.pub5">10.1002/14651858.CD002003.pub5</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369873">5369873</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28107561">28107561</a>. <q>Further research should be of high quality and should explore whether there are differences between different subtypes of beta-blockers or whether beta-blockers have differential effects on younger and older people [...] Beta-blockers were not as good at preventing the number of deaths, strokes, and heart attacks as other classes of medicines such as diuretics, calcium-channel blockers, and renin-angiotensin system inhibitors. Most of these findings come from one type of beta-blocker called atenolol. However, beta-blockers are a diverse group of medicines with different properties, and we need more well-conducted research in this area." (p. 2-3)</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Cochrane+Database+of+Systematic+Reviews&rft.atitle=Beta-blockers+for+hypertension&rft.volume=1&rft.issue=1&rft.pages=CD002003&rft.date=2017-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5369873%23id-name%3DPMC&rft_id=info%3Apmid%2F28107561&rft_id=info%3Adoi%2F10.1002%2F14651858.CD002003.pub5&rft.aulast=Wiysonge&rft.aufirst=CS&rft.au=Bradley%2C+HA&rft.au=Volmink%2C+J&rft.au=Mayosi%2C+BM&rft.au=Opie%2C+LH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5369873&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-NHSnews-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-NHSnews_19-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLadva2006" class="citation web cs1">Ladva S (28 June 2006). <a rel="nofollow" class="external text" href="https://archive.today/20080511034248/http://www.nelm.nhs.uk/Record%20Viewing/viewRecord.aspx?id=567178">"NICE and BHS launch updated hypertension guideline"</a>. <a href="/wiki/National_Institute_for_Health_and_Clinical_Excellence" class="mw-redirect" title="National Institute for Health and Clinical Excellence">National Institute for Health and Clinical Excellence</a>. Archived from <a rel="nofollow" class="external text" href="http://www.nelm.nhs.uk/Record%20Viewing/viewRecord.aspx?id=">the original</a> on 11 May 2008<span class="reference-accessdate">. Retrieved <span class="nowrap">19 August</span> 2012</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=NICE+and+BHS+launch+updated+hypertension+guideline&rft.pub=National+Institute+for+Health+and+Clinical+Excellence&rft.date=2006-06-28&rft.aulast=Ladva&rft.aufirst=S&rft_id=http%3A%2F%2Fwww.nelm.nhs.uk%2FRecord%2520Viewing%2FviewRecord.aspx%3Fid%3D&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Cruickshank2007-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-Cruickshank2007_20-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCruickshank2007" class="citation journal cs1">Cruickshank JM (August 2007). "Are we misunderstanding beta-blockers". <i>International Journal of Cardiology</i>. <b>120</b> (1): 10–27. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ijcard.2007.01.069">10.1016/j.ijcard.2007.01.069</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17433471">17433471</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Cardiology&rft.atitle=Are+we+misunderstanding+beta-blockers&rft.volume=120&rft.issue=1&rft.pages=10-27&rft.date=2007-08&rft_id=info%3Adoi%2F10.1016%2Fj.ijcard.2007.01.069&rft_id=info%3Apmid%2F17433471&rft.aulast=Cruickshank&rft.aufirst=JM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Drugs@FDA-21"><span class="mw-cite-backlink">^ <a href="#cite_ref-Drugs@FDA_21-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Drugs@FDA_21-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Drugs@FDA_21-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm">"Drugs@FDA: FDA-Approved Drugs"</a>. <i>accessdata.fda.gov</i><span class="reference-accessdate">. Retrieved <span class="nowrap">8 July</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=accessdata.fda.gov&rft.atitle=Drugs%40FDA%3A+FDA-Approved+Drugs&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fscripts%2Fcder%2Fdaf%2Findex.cfm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-22">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLindholmIbsenBorch-JohnsenOlsen2002" class="citation journal cs1">Lindholm LH, Ibsen H, Borch-Johnsen K, Olsen MH, Wachtell K, Dahlöf B, et al. (September 2002). "Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study". <i>Journal of Hypertension</i>. <b>20</b> (9): 1879–86. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00004872-200209000-00035">10.1097/00004872-200209000-00035</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12195132">12195132</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23613019">23613019</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Hypertension&rft.atitle=Risk+of+new-onset+diabetes+in+the+Losartan+Intervention+For+Endpoint+reduction+in+hypertension+study&rft.volume=20&rft.issue=9&rft.pages=1879-86&rft.date=2002-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A23613019%23id-name%3DS2CID&rft_id=info%3Apmid%2F12195132&rft_id=info%3Adoi%2F10.1097%2F00004872-200209000-00035&rft.aulast=Lindholm&rft.aufirst=LH&rft.au=Ibsen%2C+H&rft.au=Borch-Johnsen%2C+K&rft.au=Olsen%2C+MH&rft.au=Wachtell%2C+K&rft.au=Dahl%C3%B6f%2C+B&rft.au=Devereux%2C+RB&rft.au=Beevers%2C+G&rft.au=de+Faire%2C+U&rft.au=Fyhrquist%2C+F&rft.au=Julius%2C+S&rft.au=Kjeldsen%2C+SE&rft.au=Kristianson%2C+K&rft.au=Lederballe-Pedersen%2C+O&rft.au=Nieminen%2C+MS&rft.au=Omvik%2C+P&rft.au=Oparil%2C+S&rft.au=Wedel%2C+H&rft.au=Aurup%2C+P&rft.au=Edelman%2C+JM&rft.au=Snapinn%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-23">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFElliottMeyer2007" class="citation journal cs1">Elliott WJ, Meyer PM (January 2007). "Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis". <i>Lancet</i>. <b>369</b> (9557): 201–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0140-6736%2807%2960108-1">10.1016/s0140-6736(07)60108-1</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17240286">17240286</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:37044384">37044384</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Incident+diabetes+in+clinical+trials+of+antihypertensive+drugs%3A+a+network+meta-analysis&rft.volume=369&rft.issue=9557&rft.pages=201-7&rft.date=2007-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A37044384%23id-name%3DS2CID&rft_id=info%3Apmid%2F17240286&rft_id=info%3Adoi%2F10.1016%2Fs0140-6736%2807%2960108-1&rft.aulast=Elliott&rft.aufirst=WJ&rft.au=Meyer%2C+PM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-24">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLindholmCarlbergSamuelsson2005" class="citation journal cs1">Lindholm LH, Carlberg B, Samuelsson O (October 2005). "Should β blockers remain first choice in the treatment of primary hypertension? A meta-analysis". <i>The Lancet</i>. <b>366</b> (9496): 1545–1553. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0140-6736%2805%2967573-3">10.1016/S0140-6736(05)67573-3</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16257341">16257341</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:34364430">34364430</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Lancet&rft.atitle=Should+%CE%B2+blockers+remain+first+choice+in+the+treatment+of+primary+hypertension%3F+A+meta-analysis&rft.volume=366&rft.issue=9496&rft.pages=1545-1553&rft.date=2005-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A34364430%23id-name%3DS2CID&rft_id=info%3Apmid%2F16257341&rft_id=info%3Adoi%2F10.1016%2FS0140-6736%2805%2967573-3&rft.aulast=Lindholm&rft.aufirst=LH&rft.au=Carlberg%2C+B&rft.au=Samuelsson%2C+O&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-25">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKhanMcAlister2006" class="citation journal cs1">Khan N, McAlister FA (June 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1471831">"Re-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysis"</a>. <i>CMAJ</i>. <b>174</b> (12): 1737–42. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1503%2Fcmaj.060110">10.1503/cmaj.060110</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1471831">1471831</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16754904">16754904</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=CMAJ&rft.atitle=Re-examining+the+efficacy+of+beta-blockers+for+the+treatment+of+hypertension%3A+a+meta-analysis&rft.volume=174&rft.issue=12&rft.pages=1737-42&rft.date=2006-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1471831%23id-name%3DPMC&rft_id=info%3Apmid%2F16754904&rft_id=info%3Adoi%2F10.1503%2Fcmaj.060110&rft.aulast=Khan&rft.aufirst=N&rft.au=McAlister%2C+FA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1471831&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-26">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKuyperKhan2014" class="citation journal cs1">Kuyper LM, Khan NA (May 2014). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cjca.2014.01.006">"Atenolol vs nonatenolol β-blockers for the treatment of hypertension: a meta-analysis"</a>. <i>The Canadian Journal of Cardiology</i>. <b>30</b> (5 Suppl): S47-53. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cjca.2014.01.006">10.1016/j.cjca.2014.01.006</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24750981">24750981</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Canadian+Journal+of+Cardiology&rft.atitle=Atenolol+vs+nonatenolol+%CE%B2-blockers+for+the+treatment+of+hypertension%3A+a+meta-analysis&rft.volume=30&rft.issue=5+Suppl&rft.pages=S47-53&rft.date=2014-05&rft_id=info%3Adoi%2F10.1016%2Fj.cjca.2014.01.006&rft_id=info%3Apmid%2F24750981&rft.aulast=Kuyper&rft.aufirst=LM&rft.au=Khan%2C+NA&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.cjca.2014.01.006&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-pmid15530629-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid15530629_27-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMesserliGrossmanGoldbourt1998" class="citation journal cs1">Messerli FH, Grossman E, Goldbourt U (June 1998). "Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? A systematic review". <i>JAMA</i>. <b>279</b> (23): 1903–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.279.23.1903">10.1001/jama.279.23.1903</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9634263">9634263</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Are+beta-blockers+efficacious+as+first-line+therapy+for+hypertension+in+the+elderly%3F+A+systematic+review&rft.volume=279&rft.issue=23&rft.pages=1903-7&rft.date=1998-06&rft_id=info%3Adoi%2F10.1001%2Fjama.279.23.1903&rft_id=info%3Apmid%2F9634263&rft.aulast=Messerli&rft.aufirst=FH&rft.au=Grossman%2C+E&rft.au=Goldbourt%2C+U&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-KellerFrishman2003-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-KellerFrishman2003_28-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKellerFrishman2003" class="citation journal cs1">Keller S, Frishman WH (2003). "Neuropsychiatric effects of cardiovascular drug therapy". <i>Cardiol Rev</i>. <b>11</b> (2): 73–93. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F01.CRD.0000053453.89776.2D">10.1097/01.CRD.0000053453.89776.2D</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12620132">12620132</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cardiol+Rev&rft.atitle=Neuropsychiatric+effects+of+cardiovascular+drug+therapy&rft.volume=11&rft.issue=2&rft.pages=73-93&rft.date=2003&rft_id=info%3Adoi%2F10.1097%2F01.CRD.0000053453.89776.2D&rft_id=info%3Apmid%2F12620132&rft.aulast=Keller&rft.aufirst=S&rft.au=Frishman%2C+WH&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Arber1988-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-Arber1988_29-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFArber1988" class="citation journal cs1">Arber N (October 1988). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1834788">"Delirium induced by atenolol"</a>. <i>BMJ</i>. <b>297</b> (6655): 1048. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.297.6655.1048-b">10.1136/bmj.297.6655.1048-b</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1834788">1834788</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3142623">3142623</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BMJ&rft.atitle=Delirium+induced+by+atenolol&rft.volume=297&rft.issue=6655&rft.pages=1048&rft.date=1988-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1834788%23id-name%3DPMC&rft_id=info%3Apmid%2F3142623&rft_id=info%3Adoi%2F10.1136%2Fbmj.297.6655.1048-b&rft.aulast=Arber&rft.aufirst=N&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1834788&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDeLimaKharaschButler1995" class="citation journal cs1">DeLima LG, Kharasch ED, Butler S (July 1995). "Successful pharmacologic treatment of massive atenolol overdose: sequential hemodynamics and plasma atenolol concentrations". <i>Anesthesiology</i>. <b>83</b> (1): 204–7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00000542-199507000-00025">10.1097/00000542-199507000-00025</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7605000">7605000</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Successful+pharmacologic+treatment+of+massive+atenolol+overdose%3A+sequential+hemodynamics+and+plasma+atenolol+concentrations&rft.volume=83&rft.issue=1&rft.pages=204-7&rft.date=1995-07&rft_id=info%3Adoi%2F10.1097%2F00000542-199507000-00025&rft_id=info%3Apmid%2F7605000&rft.aulast=DeLima&rft.aufirst=LG&rft.au=Kharasch%2C+ED&rft.au=Butler%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-31"><span class="mw-cite-backlink"><b><a href="#cite_ref-31">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBaselt2008" class="citation book cs1">Baselt R (2008). <i>Disposition of Toxic Drugs and Chemicals in Man</i> (8th ed.). Foster City, Calif.: Biomedical Publications. pp. 116–117.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Disposition+of+Toxic+Drugs+and+Chemicals+in+Man&rft.place=Foster+City%2C+Calif.&rft.pages=116-117&rft.edition=8th&rft.pub=Biomedical+Publications&rft.date=2008&rft.aulast=Baselt&rft.aufirst=R&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Atenolol-Label-32"><span class="mw-cite-backlink">^ <a href="#cite_ref-Atenolol-Label_32-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Atenolol-Label_32-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Atenolol-Label_32-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/018240s047lbl.pdf">"TENORMIN® (atenolol) Tablets Drug Label"</a> <span class="cs1-format">(PDF)</span>. Food and Drug Administration. December 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">8 July</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=TENORMIN%C2%AE+%28atenolol%29+Tablets+Drug+Label&rft.pub=Food+and+Drug+Administration&rft.date=2023-12&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Flabel%2F2023%2F018240s047lbl.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Scheen2011-33"><span class="mw-cite-backlink">^ <a href="#cite_ref-Scheen2011_33-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Scheen2011_33-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFScheen2011" class="citation journal cs1">Scheen AJ (September 2011). "Cytochrome P450-mediated cardiovascular drug interactions". <i>Expert Opin Drug Metab Toxicol</i>. <b>7</b> (9): 1065–1082. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F17425255.2011.586337">10.1517/17425255.2011.586337</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21810031">21810031</a>. <q>β-Blockers still represent widely prescribed drugs as they cover a wide spectrum of CV indications. Obviously, it is not trivial which β-blocker to choose as they differ both with regard to their PD and PK profiles [82]. It is well known when comparing the characteristics of atenolol, bisoprolol, metoprolol (each β-1 selective) and carvedilol (β-1 and β-2 nonselective). Among these β-blockers, atenolol is mainly eliminated by renal excretion; bisoprolol is in part excreted as parent compound via the renal route (50%); the other 50% are hepatically metabolized; whereas metoprolol and carvedilol are metabolized by CYP2D6. DDIs are mainly observed with those β-blockers that are metabolized via CYP enzymes. However, it should be emphasized that, in general, β-blockers are well-tolerated safe drugs with a large therapeutic index [83].</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Opin+Drug+Metab+Toxicol&rft.atitle=Cytochrome+P450-mediated+cardiovascular+drug+interactions&rft.volume=7&rft.issue=9&rft.pages=1065-1082&rft.date=2011-09&rft_id=info%3Adoi%2F10.1517%2F17425255.2011.586337&rft_id=info%3Apmid%2F21810031&rft.aulast=Scheen&rft.aufirst=AJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-RichardsAlbertsonDerlet2015-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-RichardsAlbertsonDerlet2015_34-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRichardsAlbertsonDerletLange2015" class="citation journal cs1">Richards JR, Albertson TE, Derlet RW, Lange RA, Olson KR, Horowitz BZ (May 2015). "Treatment of toxicity from amphetamines, related derivatives, and analogues: a systematic clinical review". <i>Drug Alcohol Depend</i>. <b>150</b>: 1–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.drugalcdep.2015.01.040">10.1016/j.drugalcdep.2015.01.040</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25724076">25724076</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Alcohol+Depend&rft.atitle=Treatment+of+toxicity+from+amphetamines%2C+related+derivatives%2C+and+analogues%3A+a+systematic+clinical+review&rft.volume=150&rft.pages=1-13&rft.date=2015-05&rft_id=info%3Adoi%2F10.1016%2Fj.drugalcdep.2015.01.040&rft_id=info%3Apmid%2F25724076&rft.aulast=Richards&rft.aufirst=JR&rft.au=Albertson%2C+TE&rft.au=Derlet%2C+RW&rft.au=Lange%2C+RA&rft.au=Olson%2C+KR&rft.au=Horowitz%2C+BZ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-VetterEliaErickson2008-35"><span class="mw-cite-backlink"><b><a href="#cite_ref-VetterEliaErickson2008_35-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVetterEliaEricksonBerger2008" class="citation journal cs1">Vetter VL, Elia J, Erickson C, Berger S, Blum N, Uzark K, et al. (May 2008). "Cardiovascular monitoring of children and adolescents with heart disease receiving medications for attention deficit/hyperactivity disorder [corrected]: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing". <i>Circulation</i>. <b>117</b> (18): 2407–2423. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1161%2FCIRCULATIONAHA.107.189473">10.1161/CIRCULATIONAHA.107.189473</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18427125">18427125</a>. <q>Amphetamines (Adderall, Dexedrine): Electrophysiological Effects of Amphetamines: Amphetamines have been associated with tachyarrhythmias and sudden death.113–115 Many of the electrophysiological effects of amphetamines may be initiated by the release of norepinephrine stores from presynaptic vesicles and blocking of norepinephrine reuptake.116,117 In addition, amphetamines are potent blockers of dopamine uptake and strong central nervous system stimulants. Dopaminergic Effects of Amphetamines: In addition to the β-agonist effects of amphetamines, the dopamine receptors D1 and D2 contribute to the cardiovascular effects of methamphetamine by producing a pressor response accounting for the increase in blood pressure. The D1 receptor also is involved in mediating the positive tachycardic effects of methamphetamine.117</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Cardiovascular+monitoring+of+children+and+adolescents+with+heart+disease+receiving+medications+for+attention+deficit%2Fhyperactivity+disorder+%5Bcorrected%5D%3A+a+scientific+statement+from+the+American+Heart+Association+Council+on+Cardiovascular+Disease+in+the+Young+Congenital+Cardiac+Defects+Committee+and+the+Council+on+Cardiovascular+Nursing&rft.volume=117&rft.issue=18&rft.pages=2407-2423&rft.date=2008-05&rft_id=info%3Adoi%2F10.1161%2FCIRCULATIONAHA.107.189473&rft_id=info%3Apmid%2F18427125&rft.aulast=Vetter&rft.aufirst=VL&rft.au=Elia%2C+J&rft.au=Erickson%2C+C&rft.au=Berger%2C+S&rft.au=Blum%2C+N&rft.au=Uzark%2C+K&rft.au=Webb%2C+CL&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-SchindlerZhengTella1992-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-SchindlerZhengTella1992_36-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchindlerZhengTellaGoldberg1992" class="citation journal cs1">Schindler CW, Zheng JW, Tella SR, Goldberg SR (August 1992). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0091-3057%2892%2990031-a">"Pharmacological mechanisms in the cardiovascular effects of methamphetamine in conscious squirrel monkeys"</a>. <i>Pharmacol Biochem Behav</i>. <b>42</b> (4): 791–796. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0091-3057%2892%2990031-a">10.1016/0091-3057(92)90031-a</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1325059">1325059</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacol+Biochem+Behav&rft.atitle=Pharmacological+mechanisms+in+the+cardiovascular+effects+of+methamphetamine+in+conscious+squirrel+monkeys&rft.volume=42&rft.issue=4&rft.pages=791-796&rft.date=1992-08&rft_id=info%3Adoi%2F10.1016%2F0091-3057%2892%2990031-a&rft_id=info%3Apmid%2F1325059&rft.aulast=Schindler&rft.aufirst=CW&rft.au=Zheng%2C+JW&rft.au=Tella%2C+SR&rft.au=Goldberg%2C+SR&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0091-3057%252892%252990031-a&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-MoresCampiaNavarra1999-37"><span class="mw-cite-backlink"><b><a href="#cite_ref-MoresCampiaNavarra1999_37-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMoresCampiaNavarraCardillo1999" class="citation journal cs1">Mores N, Campia U, Navarra P, Cardillo C, Preziosi P (June 1999). "No cardiovascular effects of single-dose pseudoephedrine in patients with essential hypertension treated with beta-blockers". <i>Eur J Clin Pharmacol</i>. <b>55</b> (4): 251–254. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs002280050624">10.1007/s002280050624</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10424315">10424315</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Eur+J+Clin+Pharmacol&rft.atitle=No+cardiovascular+effects+of+single-dose+pseudoephedrine+in+patients+with+essential+hypertension+treated+with+beta-blockers&rft.volume=55&rft.issue=4&rft.pages=251-254&rft.date=1999-06&rft_id=info%3Adoi%2F10.1007%2Fs002280050624&rft_id=info%3Apmid%2F10424315&rft.aulast=Mores&rft.aufirst=N&rft.au=Campia%2C+U&rft.au=Navarra%2C+P&rft.au=Cardillo%2C+C&rft.au=Preziosi%2C+P&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-HassanGunaidElKhally2005-38"><span class="mw-cite-backlink"><b><a href="#cite_ref-HassanGunaidElKhally2005_38-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHassanGunaidEl-KhallyAl-Noami2005" class="citation journal cs1">Hassan NA, Gunaid AA, El-Khally FM, Al-Noami MY, Murray-Lyon IM (April 2005). "Khat chewing and arterial blood pressure. A randomized controlled clinical trial of alpha-1 and selective beta-1 adrenoceptor blockade". <i>Saudi Med J</i>. <b>26</b> (4): 537–541. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15900355">15900355</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Saudi+Med+J&rft.atitle=Khat+chewing+and+arterial+blood+pressure.+A+randomized+controlled+clinical+trial+of+alpha-1+and+selective+beta-1+adrenoceptor+blockade&rft.volume=26&rft.issue=4&rft.pages=537-541&rft.date=2005-04&rft_id=info%3Apmid%2F15900355&rft.aulast=Hassan&rft.aufirst=NA&rft.au=Gunaid%2C+AA&rft.au=El-Khally%2C+FM&rft.au=Al-Noami%2C+MY&rft.au=Murray-Lyon%2C+IM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-OConnellGross1990-39"><span class="mw-cite-backlink"><b><a href="#cite_ref-OConnellGross1990_39-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'ConnellGross1990" class="citation journal cs1">O'Connell MB, Gross CR (1990). "The effect of single-dose phenylpropanolamine on blood pressure in patients with hypertension controlled by beta blockers". <i>Pharmacotherapy</i>. <b>10</b> (2): 85–91. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1875-9114.1990.tb02554.x">10.1002/j.1875-9114.1990.tb02554.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2349137">2349137</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=The+effect+of+single-dose+phenylpropanolamine+on+blood+pressure+in+patients+with+hypertension+controlled+by+beta+blockers&rft.volume=10&rft.issue=2&rft.pages=85-91&rft.date=1990&rft_id=info%3Adoi%2F10.1002%2Fj.1875-9114.1990.tb02554.x&rft_id=info%3Apmid%2F2349137&rft.aulast=O%27Connell&rft.aufirst=MB&rft.au=Gross%2C+CR&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-OConnellGross1991-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-OConnellGross1991_40-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'ConnellGross1991" class="citation journal cs1">O'Connell MB, Gross CR (1991). "The effect of multiple doses of phenylpropanolamine on the blood pressure of patients whose hypertension was controlled with beta blockers". <i>Pharmacotherapy</i>. <b>11</b> (5): 376–81. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1875-9114.1991.tb02648.x">10.1002/j.1875-9114.1991.tb02648.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1684039">1684039</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=The+effect+of+multiple+doses+of+phenylpropanolamine+on+the+blood+pressure+of+patients+whose+hypertension+was+controlled+with+beta+blockers&rft.volume=11&rft.issue=5&rft.pages=376-81&rft.date=1991&rft_id=info%3Adoi%2F10.1002%2Fj.1875-9114.1991.tb02648.x&rft_id=info%3Apmid%2F1684039&rft.aulast=O%27Connell&rft.aufirst=MB&rft.au=Gross%2C+CR&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-Balon1998-41"><span class="mw-cite-backlink">^ <a href="#cite_ref-Balon1998_41-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Balon1998_41-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGaddeKrishnan1998" class="citation book cs1">Gadde KM, Krishnan KR (1998). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=VxKGwh5uQl8C&pg=PA71">"Management of Side Effects of Monoamine Oxidase Inhibitors"</a>. In Balon R (ed.). <i>Practical Management of the Side Effects of Psychotropic Drugs</i>. Medical Psychiatry Series. CRC Press. pp. 67–83 (71). <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-8247-4630-8" title="Special:BookSources/978-0-8247-4630-8"><bdi>978-0-8247-4630-8</bdi></a><span class="reference-accessdate">. Retrieved <span class="nowrap">8 July</span> 2024</span>. <q>Interestingly, in one study, orthostatic hypotension was eliminated in a group of 61 patients treated for migraine headaches with phenelzine, when a beta-blocker, atenolol, was added (15). The authors have reported that hypertensive reactions were also less frequent when the two drugs were combined. We need further experience with this combination to determine whether addition of a beta-blocker is a safe and an effective strategy for alleviation of postural hypotension in depressed patients receiving an MAOI.</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Management+of+Side+Effects+of+Monoamine+Oxidase+Inhibitors&rft.btitle=Practical+Management+of+the+Side+Effects+of+Psychotropic+Drugs&rft.series=Medical+Psychiatry+Series&rft.pages=67-83+%2871%29&rft.pub=CRC+Press&rft.date=1998&rft.isbn=978-0-8247-4630-8&rft.aulast=Gadde&rft.aufirst=KM&rft.au=Krishnan%2C+KR&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DVxKGwh5uQl8C%26pg%3DPA71&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-OBrienOyebode2003-42"><span class="mw-cite-backlink"><b><a href="#cite_ref-OBrienOyebode2003_42-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'BrienOyebode2003" class="citation journal cs1">O'Brien P, Oyebode F (2003). "Psychotropic medication and the heart". <i>Advances in Psychiatric Treatment</i>. <b>9</b> (6): 414–423. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1192%2Fapt.9.6.414">10.1192/apt.9.6.414</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1355-5146">1355-5146</a>. <q>Postural hypotension is also a risk when antipsychotics are taken with β-blockers (probably because of pharmacokinetic interaction) or with diuretics (because of Na+ or volume depletion). The same hypotensive effects might be anticipated when tricyclic antidepressants or MAOIs are co-prescribed with peripheral antihypertensive agonists. One possible exception concerns phenelzine, whose hypotensive action was reversed on co-therapy with atenolol (Merikangas & Merikangas, 1995).</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Advances+in+Psychiatric+Treatment&rft.atitle=Psychotropic+medication+and+the+heart&rft.volume=9&rft.issue=6&rft.pages=414-423&rft.date=2003&rft_id=info%3Adoi%2F10.1192%2Fapt.9.6.414&rft.issn=1355-5146&rft.aulast=O%27Brien&rft.aufirst=P&rft.au=Oyebode%2C+F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-MerikangasMerikangas1995-43"><span class="mw-cite-backlink">^ <a href="#cite_ref-MerikangasMerikangas1995_43-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-MerikangasMerikangas1995_43-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMerikangasMerikangas1995" class="citation journal cs1">Merikangas KR, Merikangas JR (November 1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0006-3223%2895%2900077-1">"Combination monoamine oxidase inhibitor and beta-blocker treatment of migraine, with anxiety and depression"</a>. <i>Biol Psychiatry</i>. <b>38</b> (9): 603–610. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0006-3223%2895%2900077-1">10.1016/0006-3223(95)00077-1</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8573662">8573662</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biol+Psychiatry&rft.atitle=Combination+monoamine+oxidase+inhibitor+and+beta-blocker+treatment+of+migraine%2C+with+anxiety+and+depression&rft.volume=38&rft.issue=9&rft.pages=603-610&rft.date=1995-11&rft_id=info%3Adoi%2F10.1016%2F0006-3223%2895%2900077-1&rft_id=info%3Apmid%2F8573662&rft.aulast=Merikangas&rft.aufirst=KR&rft.au=Merikangas%2C+JR&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0006-3223%252895%252900077-1&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-pmid33572109-44"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid33572109_44-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid33572109_44-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid33572109_44-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid33572109_44-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCojocariuMaștaleruSascăuStătescu2021" class="citation journal cs1">Cojocariu SA, Maștaleru A, Sascău RA, Stătescu C, Mitu F, Leon-Constantin MM (February 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914867">"Neuropsychiatric Consequences of Lipophilic Beta-Blockers"</a>. <i>Medicina (Kaunas)</i>. <b>57</b> (2): 155. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fmedicina57020155">10.3390/medicina57020155</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914867">7914867</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33572109">33572109</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Medicina+%28Kaunas%29&rft.atitle=Neuropsychiatric+Consequences+of+Lipophilic+Beta-Blockers&rft.volume=57&rft.issue=2&rft.pages=155&rft.date=2021-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7914867%23id-name%3DPMC&rft_id=info%3Apmid%2F33572109&rft_id=info%3Adoi%2F10.3390%2Fmedicina57020155&rft.aulast=Cojocariu&rft.aufirst=SA&rft.au=Ma%C8%99taleru%2C+A&rft.au=Sasc%C4%83u%2C+RA&rft.au=St%C4%83tescu%2C+C&rft.au=Mitu%2C+F&rft.au=Leon-Constantin%2C+MM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7914867&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-PubChem-45"><span class="mw-cite-backlink">^ <a href="#cite_ref-PubChem_45-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-PubChem_45-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-PubChem_45-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/2249">"Atenolol"</a>. <i>PubChem</i><span class="reference-accessdate">. Retrieved <span class="nowrap">1 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=PubChem&rft.atitle=Atenolol&rft_id=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fcompound%2F2249&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-DrugBank-46"><span class="mw-cite-backlink"><b><a href="#cite_ref-DrugBank_46-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://go.drugbank.com/drugs/DB00335">"Atenolol: Uses, Interactions, Mechanism of Action"</a>. <i>DrugBank Online</i>. 13 August 2004<span class="reference-accessdate">. Retrieved <span class="nowrap">1 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DrugBank+Online&rft.atitle=Atenolol%3A+Uses%2C+Interactions%2C+Mechanism+of+Action&rft.date=2004-08-13&rft_id=https%3A%2F%2Fgo.drugbank.com%2Fdrugs%2FDB00335&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-ChemSpider-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-ChemSpider_47-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.2162.html">"DL-Atenolol"</a>. <i>ChemSpider</i>. 21 July 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">1 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ChemSpider&rft.atitle=DL-Atenolol&rft.date=2022-07-21&rft_id=https%3A%2F%2Fwww.chemspider.com%2FChemical-Structure.2162.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-:0-48"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_48-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_48-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:0_48-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:0_48-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEpstein2017" class="citation news cs1">Epstein D (22 July 2017). <a rel="nofollow" class="external text" href="https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/">"When Evidence Says No, But Doctors Say Yes"</a>. <i><a href="/wiki/The_Atlantic" title="The Atlantic">The Atlantic</a></i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180509150759/https://www.theatlantic.com/health/archive/2017/02/when-evidence-says-no-but-doctors-say-yes/517368/">Archived</a> from the original on 9 May 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">8 May</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Atlantic&rft.atitle=When+Evidence+Says+No%2C+But+Doctors+Say+Yes&rft.date=2017-07-22&rft.aulast=Epstein&rft.aufirst=D&rft_id=https%3A%2F%2Fwww.theatlantic.com%2Fhealth%2Farchive%2F2017%2F02%2Fwhen-evidence-says-no-but-doctors-say-yes%2F517368%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> <li id="cite_note-49"><span class="mw-cite-backlink"><b><a href="#cite_ref-49">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChoiOhLeeLim2018" class="citation journal cs1">Choi HY, Oh IJ, Lee JA, Lim J, Kim YS, Jeon TH, et al. (November 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250947">"Factors Affecting Adherence to Antihypertensive Medication"</a>. <i>Korean Journal of Family Medicine</i>. <b>39</b> (6): 325–332. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4082%2Fkjfm.17.0041">10.4082/kjfm.17.0041</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250947">6250947</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30384549">30384549</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Korean+Journal+of+Family+Medicine&rft.atitle=Factors+Affecting+Adherence+to+Antihypertensive+Medication&rft.volume=39&rft.issue=6&rft.pages=325-332&rft.date=2018-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6250947%23id-name%3DPMC&rft_id=info%3Apmid%2F30384549&rft_id=info%3Adoi%2F10.4082%2Fkjfm.17.0041&rft.aulast=Choi&rft.aufirst=HY&rft.au=Oh%2C+IJ&rft.au=Lee%2C+JA&rft.au=Lim%2C+J&rft.au=Kim%2C+YS&rft.au=Jeon%2C+TH&rft.au=Cheong%2C+YS&rft.au=Kim%2C+DH&rft.au=Kim%2C+MC&rft.au=Lee%2C+SY&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6250947&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAtenolol" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Beta_blockers" title="Template:Beta blockers"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Beta_blockers" class="mw-redirect" title="Template talk:Beta blockers"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Beta_blockers" title="Special:EditPage/Template:Beta blockers"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Beta_blockers_(C07)" style="font-size:114%;margin:0 4em"><a href="/wiki/Beta_blocker" title="Beta blocker">Beta blockers</a> (<a href="/wiki/ATC_code_C07" title="ATC code C07">C07</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta_adrenergic_receptor" class="mw-redirect" title="Beta adrenergic receptor">β</a>, non-selective</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alprenolol" title="Alprenolol">Alprenolol</a></li> <li><a href="/wiki/Bopindolol" title="Bopindolol">Bopindolol</a></li> <li><a href="/wiki/Bupranolol" title="Bupranolol">Bupranolol</a></li> <li><a href="/wiki/Carteolol" title="Carteolol">Carteolol</a></li> <li><a href="/wiki/Cloranolol" title="Cloranolol">Cloranolol</a></li> <li><a href="/wiki/Mepindolol" title="Mepindolol">Mepindolol</a></li> <li><a href="/wiki/Nadolol" title="Nadolol">Nadolol</a></li> <li><a href="/wiki/Oxprenolol" title="Oxprenolol">Oxprenolol</a></li> <li><a href="/wiki/Penbutolol" title="Penbutolol">Penbutolol</a></li> <li><a href="/wiki/Pindolol" title="Pindolol">Pindolol</a>/<a href="/wiki/Iodopindolol" title="Iodopindolol">Iodopindolol</a></li> <li><a href="/wiki/Propranolol" title="Propranolol">Propranolol</a><sup>#</sup></li> <li><a href="/wiki/Sotalol" title="Sotalol">Sotalol</a></li> <li><a href="/wiki/Tertatolol" title="Tertatolol">Tertatolol</a></li> <li><a href="/wiki/Timolol" title="Timolol">Timolol</a><sup>#</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β<sub>1</sub></a>-selective</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acebutolol" title="Acebutolol">Acebutolol</a></li> <li><a class="mw-selflink selflink">Atenolol</a></li> <li><a href="/wiki/Betaxolol" title="Betaxolol">Betaxolol</a></li> <li><a href="/wiki/Bevantolol" title="Bevantolol">Bevantolol</a></li> <li><a href="/wiki/Bisoprolol" title="Bisoprolol">Bisoprolol</a><sup>#</sup></li> <li><a href="/wiki/Celiprolol" title="Celiprolol">Celiprolol</a></li> <li><a href="/wiki/Epanolol" title="Epanolol">Epanolol</a></li> <li><a href="/wiki/Esmolol" title="Esmolol">Esmolol</a></li> <li><a href="/wiki/Landiolol" title="Landiolol">Landiolol</a></li> <li><a href="/wiki/Metoprolol" title="Metoprolol">Metoprolol</a></li> <li><a href="/wiki/Nebivolol" title="Nebivolol">Nebivolol</a></li> <li><a href="/wiki/Practolol" title="Practolol">Practolol</a></li> <li><a href="/wiki/Talinolol" title="Talinolol">Talinolol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β<sub>2</sub></a>-selective</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Butaxamine" title="Butaxamine">Butaxamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α<sub>1</sub></a>- + β-selective</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Arotinolol" title="Arotinolol">Arotinolol</a></li> <li><a href="/wiki/Carvedilol" title="Carvedilol">Carvedilol</a></li> <li><a href="/wiki/Labetalol" title="Labetalol">Labetalol</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Adrenergic_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Adrenergic_receptor_modulators" title="Template:Adrenergic receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Adrenergic_receptor_modulators" title="Template talk:Adrenergic receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Adrenergic_receptor_modulators" title="Special:EditPage/Template:Adrenergic receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Adrenergic_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Adrenergic_receptor" title="Adrenergic receptor">Adrenergic receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α<sub>1</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/6-Fluoronorepinephrine" title="6-Fluoronorepinephrine">6-FNE</a></li> <li><a href="/wiki/Amidephrine" title="Amidephrine">Amidephrine</a></li> <li><a href="/wiki/Buspirone" title="Buspirone">Buspirone</a></li> <li><a href="/wiki/Cirazoline" title="Cirazoline">Cirazoline</a></li> <li><a href="/wiki/Corbadrine" title="Corbadrine">Corbadrine</a></li> <li><a href="/wiki/Deoxyepinephrine" title="Deoxyepinephrine">Deoxyepinephrine (epinine, <i>N</i>-methyldopamine)</a></li> <li><a href="/wiki/Desglymidodrine" title="Desglymidodrine">Desglymidodrine</a></li> <li><a href="/w/index.php?title=Dexisometheptene&action=edit&redlink=1" class="new" title="Dexisometheptene (page does not exist)">Dexisometheptene</a></li> <li><a href="/wiki/Dipivefrine" title="Dipivefrine">Dipivefrine</a></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a></li> <li><a href="/wiki/Droxidopa" title="Droxidopa">Droxidopa (L-DOPS)</a></li> <li><a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">Epinephrine</a></li> <li><a href="/wiki/Etilefrine" title="Etilefrine">Etilefrine</a></li> <li><a href="/wiki/Etilevodopa" title="Etilevodopa">Etilevodopa</a></li> <li><a href="/wiki/Ethylnorepinephrine" title="Ethylnorepinephrine">Ethylnorepinephrine</a></li> <li><a href="/wiki/Ibopamine" title="Ibopamine">Ibopamine</a></li> <li><a href="/wiki/Indanidine" title="Indanidine">Indanidine</a></li> <li><a href="/wiki/Isometheptene" title="Isometheptene">Isometheptene</a></li> <li><a href="/wiki/L-DOPA" title="L-DOPA">L-DOPA (levodopa)</a></li> <li><a href="/wiki/Phenylalanine" title="Phenylalanine">L-Phenylalanine</a></li> <li><a href="/wiki/Tyrosine" title="Tyrosine">L-Tyrosine</a></li> <li><a href="/wiki/Melevodopa" title="Melevodopa">Melevodopa</a></li> <li><a href="/wiki/Metaraminol" title="Metaraminol">Metaraminol</a></li> <li><a href="/wiki/Methoxamine" title="Methoxamine">Methoxamine</a></li> <li><a href="/wiki/Methyldopa" title="Methyldopa">Methyldopa</a></li> <li><a href="/wiki/Midodrine" title="Midodrine">Midodrine</a></li> <li><a href="/wiki/Naphazoline" title="Naphazoline">Naphazoline</a></li> <li><a href="/wiki/Norepinephrine" title="Norepinephrine">Norepinephrine</a></li> <li><a href="/wiki/Octopamine" title="Octopamine">Octopamine</a></li> <li><a href="/wiki/Oxymetazoline" title="Oxymetazoline">Oxymetazoline</a></li> <li><a href="/wiki/Phenylephrine" title="Phenylephrine">Phenylephrine</a></li> <li><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Phenylpropanolamine</a></li> <li><a href="/wiki/Synephrine" title="Synephrine">Synephrine</a></li> <li><a href="/wiki/Tetryzoline" title="Tetryzoline">Tetryzoline</a></li> <li><a href="/wiki/Tiamenidine" title="Tiamenidine">Tiamenidine</a></li> <li><a href="/wiki/XP21279" class="mw-redirect" title="XP21279">XP21279</a></li> <li><a href="/wiki/Xylometazoline" title="Xylometazoline">Xylometazoline</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abanoquil" title="Abanoquil">Abanoquil</a></li> <li><a href="/wiki/Ajmalicine" title="Ajmalicine">Ajmalicine</a></li> <li><a href="/wiki/Alfuzosin" title="Alfuzosin">Alfuzosin</a></li> <li><a href="/wiki/Anisodamine" title="Anisodamine">Anisodamine</a></li> <li><a href="/wiki/Anisodine" title="Anisodine">Anisodine</a></li> <li><a href="/wiki/Atiprosin" title="Atiprosin">Atiprosin</a></li> <li><a href="/wiki/Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>)</li> <li><a href="/wiki/Benoxathian" title="Benoxathian">Benoxathian</a></li> <li><a href="/wiki/Beta_blocker" title="Beta blocker">Beta blockers</a> (e.g., <a href="/wiki/Adimolol" title="Adimolol">adimolol</a>, <a href="/wiki/Amosulalol" title="Amosulalol">amosulalol</a>, <a href="/wiki/Arotinolol" title="Arotinolol">arotinolol</a>, <a href="/wiki/Carvedilol" title="Carvedilol">carvedilol</a>, <a href="/wiki/Eugenodilol" title="Eugenodilol">eugenodilol</a>, <a href="/wiki/Labetalol" title="Labetalol">labetalol</a>)</li> <li><a href="/wiki/Buflomedil" title="Buflomedil">Buflomedil</a></li> <li><a href="/wiki/Bunazosin" title="Bunazosin">Bunazosin</a></li> <li><a href="/wiki/Corynanthine" title="Corynanthine">Corynanthine</a></li> <li><a href="/wiki/Dapiprazole" title="Dapiprazole">Dapiprazole</a></li> <li><a href="/wiki/Domesticine" title="Domesticine">Domesticine</a></li> <li><a href="/wiki/Doxazosin" title="Doxazosin">Doxazosin</a></li> <li><a href="/wiki/Ergoline" title="Ergoline">Ergolines</a> (e.g., <a href="/wiki/Acetergamine" title="Acetergamine">acetergamine</a>, <a href="/wiki/Ergotamine" title="Ergotamine">ergotamine</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Lisuride" title="Lisuride">lisuride</a>, <a href="/wiki/Nicergoline" title="Nicergoline">nicergoline</a>, <a href="/wiki/Terguride" title="Terguride">terguride</a>)</li> <li><a href="/wiki/Etoperidone" title="Etoperidone">Etoperidone</a></li> <li><a href="/wiki/Fenspiride" title="Fenspiride">Fenspiride</a></li> <li><a href="/wiki/Hydroxyzine" title="Hydroxyzine">Hydroxyzine</a></li> <li><a href="/wiki/Indoramin" title="Indoramin">Indoramin</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/L-765,314" title="L-765,314">L-765,314</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Mepiprazole" title="Mepiprazole">Mepiprazole</a></li> <li><a href="/wiki/Metazosin" title="Metazosin">Metazosin</a></li> <li><a href="/wiki/Monatepil" title="Monatepil">Monatepil</a></li> <li><a href="/wiki/Moxisylyte" title="Moxisylyte">Moxisylyte</a></li> <li><a href="/wiki/Naftopidil" title="Naftopidil">Naftopidil</a></li> <li><a href="/wiki/Nantenine" title="Nantenine">Nantenine</a></li> <li><a href="/wiki/Neldazosin" title="Neldazosin">Neldazosin</a></li> <li><a href="/wiki/Niaprazine" title="Niaprazine">Niaprazine</a></li> <li><a href="/wiki/Niguldipine" title="Niguldipine">Niguldipine</a></li> <li><a href="/wiki/Pardoprunox" title="Pardoprunox">Pardoprunox</a></li> <li><a href="/wiki/Pelanserin" title="Pelanserin">Pelanserin</a></li> <li><a href="/wiki/Perlapine" title="Perlapine">Perlapine</a></li> <li><a href="/wiki/Phendioxan" title="Phendioxan">Phendioxan</a></li> <li><a href="/wiki/Phenoxybenzamine" title="Phenoxybenzamine">Phenoxybenzamine</a></li> <li><a href="/wiki/Phentolamine" title="Phentolamine">Phentolamine</a></li> <li><a href="/wiki/Phenylpiperazine" title="Phenylpiperazine">Phenylpiperazine</a> <a href="/wiki/Antidepressant" title="Antidepressant">antidepressants</a> (e.g., <a href="/wiki/Hydroxynefazodone" title="Hydroxynefazodone">hydroxynefazodone</a>, <a href="/wiki/Nefazodone" title="Nefazodone">nefazodone</a>, <a href="/wiki/Trazodone" title="Trazodone">trazodone</a>, <a href="/wiki/Triazoledione" title="Triazoledione">triazoledione</a>)</li> <li><a href="/wiki/Piperoxan" title="Piperoxan">Piperoxan</a></li> <li><a href="/wiki/Prazosin" title="Prazosin">Prazosin</a></li> <li><a href="/wiki/Quinazosin" title="Quinazosin">Quinazosin</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Silodosin" title="Silodosin">Silodosin</a></li> <li><a href="/wiki/Spegatrine" title="Spegatrine">Spegatrine</a></li> <li><a href="/wiki/Spiperone" title="Spiperone">Spiperone</a></li> <li><a href="/wiki/Talipexole" title="Talipexole">Talipexole</a></li> <li><a href="/wiki/Tamsulosin" title="Tamsulosin">Tamsulosin</a></li> <li><a href="/wiki/Terazosin" title="Terazosin">Terazosin</a></li> <li><a href="/wiki/Tiodazosin" title="Tiodazosin">Tiodazosin</a></li> <li><a href="/wiki/Tolazoline" title="Tolazoline">Tolazoline</a></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> (e.g., <a href="/wiki/Amoxapine" title="Amoxapine">amoxapine</a>, <a href="/wiki/Maprotiline" title="Maprotiline">maprotiline</a>, <a href="/wiki/Mianserin" title="Mianserin">mianserin</a>)</li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Clomipramine" title="Clomipramine">clomipramine</a>, <a href="/wiki/Doxepin" title="Doxepin">doxepin</a>, <a href="/wiki/Imipramine" title="Imipramine">imipramine</a>, <a href="/wiki/Trimipramine" title="Trimipramine">trimipramine</a>)</li> <li><a href="/wiki/Trimazosin" title="Trimazosin">Trimazosin</a></li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Fluphenazine" title="Fluphenazine">fluphenazine</a>, <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Thioridazine" title="Thioridazine">thioridazine</a>)</li> <li><a href="/wiki/Urapidil" title="Urapidil">Urapidil</a></li> <li><a href="/wiki/WB-4101" title="WB-4101">WB-4101</a></li> <li><a href="/wiki/Zolertine" title="Zolertine">Zolertine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α<sub>2</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/(R)-3-Nitrobiphenyline" title="(R)-3-Nitrobiphenyline">(R)-3-Nitrobiphenyline</a></li> <li><a href="/wiki/4-NEMD" title="4-NEMD">4-NEMD</a></li> <li><a href="/wiki/6-Fluoronorepinephrine" title="6-Fluoronorepinephrine">6-FNE</a></li> <li><a href="/wiki/Amitraz" title="Amitraz">Amitraz</a></li> <li><a href="/wiki/Apraclonidine" title="Apraclonidine">Apraclonidine</a></li> <li><a href="/wiki/Brimonidine" title="Brimonidine">Brimonidine</a></li> <li><a href="/wiki/Clonidine" title="Clonidine">Clonidine</a></li> <li><a href="/wiki/Corbadrine" title="Corbadrine">Corbadrine</a></li> <li><a href="/wiki/Deoxyepinephrine" title="Deoxyepinephrine">Deoxyepinephrine (epinine, <i>N</i>-methyldopamine)</a></li> <li><a href="/wiki/Detomidine" title="Detomidine">Detomidine</a></li> <li><a href="/wiki/Dexmedetomidine" title="Dexmedetomidine">Dexmedetomidine</a></li> <li><a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">Dihydroergotamine</a></li> <li><a href="/wiki/Dipivefrine" title="Dipivefrine">Dipivefrine</a></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a></li> <li><a href="/wiki/Droxidopa" title="Droxidopa">Droxidopa (L-DOPS)</a></li> <li><a href="/wiki/Etilevodopa" title="Etilevodopa">Etilevodopa</a></li> <li><a href="/wiki/Ergotamine" title="Ergotamine">Ergotamine</a></li> <li><a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">Epinephrine</a></li> <li><a href="/wiki/Etilefrine" title="Etilefrine">Etilefrine</a></li> <li><a href="/wiki/Ethylnorepinephrine" title="Ethylnorepinephrine">Ethylnorepinephrine</a></li> <li><a href="/wiki/Guanabenz" title="Guanabenz">Guanabenz</a></li> <li><a href="/wiki/Guanfacine" title="Guanfacine">Guanfacine</a></li> <li><a href="/wiki/Guanoxabenz" title="Guanoxabenz">Guanoxabenz</a></li> <li><a href="/wiki/L-DOPA" title="L-DOPA">L-DOPA (levodopa)</a></li> <li><a href="/wiki/Phenylalanine" title="Phenylalanine">L-Phenylalanine</a></li> <li><a href="/wiki/Tyrosine" title="Tyrosine">L-Tyrosine</a></li> <li><a href="/wiki/Ibopamine" title="Ibopamine">Ibopamine</a></li> <li><a href="/wiki/Lofexidine" title="Lofexidine">Lofexidine</a></li> <li><a href="/wiki/Medetomidine" title="Medetomidine">Medetomidine</a></li> <li><a href="/wiki/Melevodopa" title="Melevodopa">Melevodopa</a></li> <li><a href="/wiki/Methyldopa" title="Methyldopa">Methyldopa</a></li> <li><a href="/wiki/Mivazerol" title="Mivazerol">Mivazerol</a></li> <li><a href="/wiki/Moxonidine" title="Moxonidine">Moxonidine</a></li> <li><a href="/wiki/Naphazoline" title="Naphazoline">Naphazoline</a></li> <li><a href="/wiki/Norepinephrine" title="Norepinephrine">Norepinephrine</a></li> <li><a href="/wiki/Oxymetazoline" title="Oxymetazoline">Oxymetazoline</a></li> <li><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Phenylpropanolamine</a></li> <li><a href="/wiki/Piperoxan" title="Piperoxan">Piperoxan</a></li> <li><a href="/wiki/PS75" title="PS75">PS75</a></li> <li><a href="/w/index.php?title=Rezatomidine&action=edit&redlink=1" class="new" title="Rezatomidine (page does not exist)">Rezatomidine</a></li> <li><a href="/wiki/Rilmenidine" title="Rilmenidine">Rilmenidine</a></li> <li><a href="/wiki/Romifidine" title="Romifidine">Romifidine</a></li> <li><a href="/wiki/Talipexole" title="Talipexole">Talipexole</a></li> <li><a href="/w/index.php?title=Tasipimidine&action=edit&redlink=1" class="new" title="Tasipimidine (page does not exist)">Tasipimidine</a></li> <li><a href="/wiki/Tetryzoline" title="Tetryzoline">Tetryzoline</a></li> <li><a href="/wiki/Tiamenidine" title="Tiamenidine">Tiamenidine</a></li> <li><a href="/wiki/Tizanidine" title="Tizanidine">Tizanidine</a></li> <li><a href="/wiki/Tolonidine" title="Tolonidine">Tolonidine</a></li> <li><a href="/wiki/Urapidil" title="Urapidil">Urapidil</a></li> <li><a href="/wiki/Vatinoxan" class="mw-redirect" title="Vatinoxan">Vatinoxan</a></li> <li><a href="/wiki/XP21279" class="mw-redirect" title="XP21279">XP21279</a></li> <li><a href="/wiki/Xylazine" title="Xylazine">Xylazine</a></li> <li><a href="/wiki/Xylometazoline" title="Xylometazoline">Xylometazoline</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pyrimidinylpiperazine" title="Pyrimidinylpiperazine">1-PP</a></li> <li><a href="/wiki/Adimolol" title="Adimolol">Adimolol</a></li> <li><a href="/wiki/Amesergide" title="Amesergide">Amesergide</a></li> <li><a href="/wiki/Aptazapine" title="Aptazapine">Aptazapine</a></li> <li><a href="/wiki/Atipamezole" title="Atipamezole">Atipamezole</a></li> <li><a href="/wiki/Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> (e.g., <a href="/wiki/Asenapine" title="Asenapine">asenapine</a>, <a href="/wiki/Brexpiprazole" title="Brexpiprazole">brexpiprazole</a>, <a href="/wiki/Clozapine" title="Clozapine">clozapine</a>, <a href="/wiki/Lurasidone" title="Lurasidone">lurasidone</a>, <a href="/wiki/Olanzapine" title="Olanzapine">olanzapine</a>, <a href="/wiki/Paliperidone" title="Paliperidone">paliperidone</a>, <a href="/wiki/Quetiapine" title="Quetiapine">quetiapine</a>, <a href="/wiki/Risperidone" title="Risperidone">risperidone</a>, <a href="/wiki/Zotepine" title="Zotepine">zotepine</a>)</li> <li><a href="/wiki/Azapirone" title="Azapirone">Azapirones</a> (e.g., <a href="/wiki/Buspirone" title="Buspirone">buspirone</a>, <a href="/wiki/Gepirone" title="Gepirone">gepirone</a>, <a href="/wiki/Ipsapirone" title="Ipsapirone">ipsapirone</a>, <a href="/wiki/Tandospirone" title="Tandospirone">tandospirone</a>)</li> <li><a href="/wiki/BRL-44408" title="BRL-44408">BRL-44408</a></li> <li><a href="/wiki/Buflomedil" title="Buflomedil">Buflomedil</a></li> <li><a href="/wiki/Cirazoline" title="Cirazoline">Cirazoline</a></li> <li><a href="/wiki/Efaroxan" title="Efaroxan">Efaroxan</a></li> <li><a href="/wiki/Esmirtazapine" title="Esmirtazapine">Esmirtazapine</a></li> <li><a href="/wiki/Fenmetozole" title="Fenmetozole">Fenmetozole</a></li> <li><a href="/wiki/Fluparoxan" title="Fluparoxan">Fluparoxan</a></li> <li><a href="/wiki/Idazoxan" title="Idazoxan">Idazoxan</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/Lisuride" title="Lisuride">Lisuride</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a></li> <li><a href="/wiki/NAN-190" title="NAN-190">NAN-190</a></li> <li><a href="/wiki/Pardoprunox" title="Pardoprunox">Pardoprunox</a></li> <li><a href="/wiki/Phentolamine" title="Phentolamine">Phentolamine</a></li> <li><a href="/wiki/Phenoxybenzamine" title="Phenoxybenzamine">Phenoxybenzamine</a></li> <li><a href="/wiki/Piperoxan" title="Piperoxan">Piperoxan</a></li> <li><a href="/wiki/Piribedil" title="Piribedil">Piribedil</a></li> <li><a href="/wiki/Rauwolscine" title="Rauwolscine">Rauwolscine</a></li> <li><a href="/wiki/Rotigotine" title="Rotigotine">Rotigotine</a></li> <li><a href="/wiki/Setiptiline" title="Setiptiline">Setiptiline</a></li> <li><a href="/wiki/Spegatrine" title="Spegatrine">Spegatrine</a></li> <li><a href="/wiki/Spiroxatrine" title="Spiroxatrine">Spiroxatrine</a></li> <li><a href="/wiki/Sunepitron" title="Sunepitron">Sunepitron</a></li> <li><a href="/wiki/Terguride" title="Terguride">Terguride</a></li> <li><a href="/wiki/Tolazoline" title="Tolazoline">Tolazoline</a></li> <li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> (e.g., <a href="/wiki/Chlorpromazine" title="Chlorpromazine">chlorpromazine</a>, <a href="/wiki/Fluphenazine" title="Fluphenazine">fluphenazine</a>, <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Thioridazine" title="Thioridazine">thioridazine</a>)</li> <li><a href="/wiki/Yohimbine" title="Yohimbine">Yohimbine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%CE%92-adrenergic_receptor" class="mw-redirect" title="Β-adrenergic receptor">β</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abediterol" title="Abediterol">Abediterol</a></li> <li><a href="/wiki/Alifedrine" title="Alifedrine">Alifedrine</a></li> <li><a href="/wiki/Amibegron" title="Amibegron">Amibegron</a></li> <li><a href="/wiki/Arbutamine" title="Arbutamine">Arbutamine</a></li> <li><a href="/wiki/Arformoterol" title="Arformoterol">Arformoterol</a></li> <li><a href="/wiki/Arotinolol" title="Arotinolol">Arotinolol</a></li> <li><a href="/wiki/Bromoacetylalprenololmenthane" title="Bromoacetylalprenololmenthane">BAAM</a></li> <li><a href="/wiki/Bambuterol" title="Bambuterol">Bambuterol</a></li> <li><a href="/wiki/Befunolol" title="Befunolol">Befunolol</a></li> <li><a href="/wiki/Bitolterol" title="Bitolterol">Bitolterol</a></li> <li><a href="/wiki/Broxaterol" title="Broxaterol">Broxaterol</a></li> <li><a href="/wiki/Buphenine" title="Buphenine">Buphenine</a></li> <li><a href="/wiki/Carbuterol" title="Carbuterol">Carbuterol</a></li> <li><a href="/wiki/Carmoterol" title="Carmoterol">Carmoterol</a></li> <li><a href="/wiki/Cimaterol" title="Cimaterol">Cimaterol</a></li> <li><a href="/wiki/Clenbuterol" title="Clenbuterol">Clenbuterol</a></li> <li><a href="/wiki/Colterol" title="Colterol">Colterol</a></li> <li><a href="/wiki/Corbadrine" title="Corbadrine">Corbadrine</a></li> <li><a href="/wiki/Denopamine" title="Denopamine">Denopamine</a></li> <li><a href="/wiki/Deoxyepinephrine" title="Deoxyepinephrine">Deoxyepinephrine (epinine, <i>N</i>-methyldopamine)</a></li> <li><a href="/wiki/Dipivefrine" title="Dipivefrine">Dipivefrine</a></li> <li><a href="/wiki/Dobutamine" title="Dobutamine">Dobutamine</a></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a></li> <li><a href="/wiki/Dopexamine" title="Dopexamine">Dopexamine</a></li> <li><a href="/wiki/Droxidopa" title="Droxidopa">Droxidopa (L-DOPS)</a></li> <li><a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">Epinephrine</a></li> <li><a href="/wiki/Etafedrine" title="Etafedrine">Etafedrine</a></li> <li><a href="/wiki/Etilefrine" title="Etilefrine">Etilefrine</a></li> <li><a href="/wiki/Etilevodopa" title="Etilevodopa">Etilevodopa</a></li> <li><a href="/wiki/Ethylnorepinephrine" title="Ethylnorepinephrine">Ethylnorepinephrine</a></li> <li><a href="/wiki/Eugenodilol" title="Eugenodilol">Eugenodilol</a></li> <li><a href="/wiki/Fenoterol" title="Fenoterol">Fenoterol</a></li> <li><a href="/wiki/Formoterol" title="Formoterol">Formoterol</a></li> <li><a href="/wiki/Hexoprenaline" title="Hexoprenaline">Hexoprenaline</a></li> <li><a href="/wiki/Higenamine" title="Higenamine">Higenamine</a></li> <li><a href="/wiki/Ibopamine" title="Ibopamine">Ibopamine</a></li> <li><a href="/wiki/Indacaterol" title="Indacaterol">Indacaterol</a></li> <li><a href="/wiki/Isoetarine" title="Isoetarine">Isoetarine</a></li> <li><a href="/wiki/Isoprenaline" title="Isoprenaline">Isoprenaline</a></li> <li><a href="/wiki/Isoxsuprine" title="Isoxsuprine">Isoxsuprine</a></li> <li><a href="/wiki/L-DOPA" title="L-DOPA">L-DOPA (levodopa)</a></li> <li><a href="/wiki/Phenylalanine" title="Phenylalanine">L-Phenylalanine</a></li> <li><a href="/wiki/Tyrosine" title="Tyrosine">L-Tyrosine</a></li> <li><a href="/wiki/Levosalbutamol" title="Levosalbutamol">Levosalbutamol</a></li> <li><a href="/wiki/Lubabegron" title="Lubabegron">Lubabegron</a></li> <li><a href="/wiki/Mabuterol" title="Mabuterol">Mabuterol</a></li> <li><a href="/wiki/Melevodopa" title="Melevodopa">Melevodopa</a></li> <li><a href="/wiki/Methoxyphenamine" title="Methoxyphenamine">Methoxyphenamine</a></li> <li><a href="/wiki/Methyldopa" title="Methyldopa">Methyldopa</a></li> <li><a href="/wiki/Mirabegron" title="Mirabegron">Mirabegron</a></li> <li><a href="/wiki/Norepinephrine" title="Norepinephrine">Norepinephrine</a></li> <li><a href="/wiki/Orciprenaline" title="Orciprenaline">Orciprenaline</a></li> <li><a href="/wiki/Oxyfedrine" title="Oxyfedrine">Oxyfedrine</a></li> <li><a href="/wiki/PF-610355" title="PF-610355">PF-610355</a></li> <li><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Phenylpropanolamine</a></li> <li><a href="/wiki/Pirbuterol" title="Pirbuterol">Pirbuterol</a></li> <li><a href="/wiki/Prenalterol" title="Prenalterol">Prenalterol</a></li> <li><a href="/wiki/Ractopamine" title="Ractopamine">Ractopamine</a></li> <li><a href="/wiki/Procaterol" title="Procaterol">Procaterol</a></li> <li><a href="/wiki/Reproterol" title="Reproterol">Reproterol</a></li> <li><a href="/wiki/Rimiterol" title="Rimiterol">Rimiterol</a></li> <li><a href="/wiki/Ritodrine" title="Ritodrine">Ritodrine</a></li> <li><a href="/wiki/Salbutamol" title="Salbutamol">Salbutamol</a></li> <li><a href="/wiki/Salmeterol" title="Salmeterol">Salmeterol</a></li> <li><a href="/wiki/Solabegron" title="Solabegron">Solabegron</a></li> <li><a href="/wiki/Terbutaline" title="Terbutaline">Terbutaline</a></li> <li><a href="/wiki/Tretoquinol" title="Tretoquinol">Tretoquinol</a></li> <li><a href="/wiki/Tulobuterol" title="Tulobuterol">Tulobuterol</a></li> <li><a href="/wiki/Vibegron" title="Vibegron">Vibegron</a></li> <li><a href="/wiki/Vilanterol" title="Vilanterol">Vilanterol</a></li> <li><a href="/wiki/Xamoterol" title="Xamoterol">Xamoterol</a></li> <li><a href="/wiki/XP21279" class="mw-redirect" title="XP21279">XP21279</a></li> <li><a href="/wiki/Zilpaterol" title="Zilpaterol">Zilpaterol</a></li> <li><a href="/wiki/Zinterol" title="Zinterol">Zinterol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acebutolol" title="Acebutolol">Acebutolol</a></li> <li><a href="/wiki/Adaprolol" title="Adaprolol">Adaprolol</a></li> <li><a href="/wiki/Adimolol" title="Adimolol">Adimolol</a></li> <li><a href="/wiki/Afurolol" title="Afurolol">Afurolol</a></li> <li><a href="/wiki/Alprenolol" title="Alprenolol">Alprenolol</a></li> <li><a href="/wiki/Alprenoxime" title="Alprenoxime">Alprenoxime</a></li> <li><a href="/wiki/Amosulalol" title="Amosulalol">Amosulalol</a></li> <li><a href="/wiki/Ancarolol" title="Ancarolol">Ancarolol</a></li> <li><a href="/wiki/Arnolol" title="Arnolol">Arnolol</a></li> <li><a href="/wiki/Arotinolol" title="Arotinolol">Arotinolol</a></li> <li><a class="mw-selflink selflink">Atenolol</a></li> <li><a href="/wiki/Befunolol" title="Befunolol">Befunolol</a></li> <li><a href="/wiki/Betaxolol" title="Betaxolol">Betaxolol</a></li> <li><a href="/wiki/Bevantolol" title="Bevantolol">Bevantolol</a></li> <li><a href="/wiki/Bisoprolol" title="Bisoprolol">Bisoprolol</a></li> <li><a href="/wiki/Bopindolol" title="Bopindolol">Bopindolol</a></li> <li><a href="/wiki/Bornaprolol" title="Bornaprolol">Bornaprolol</a></li> <li><a href="/wiki/Brefonalol" title="Brefonalol">Brefonalol</a></li> <li><a href="/wiki/Bucindolol" title="Bucindolol">Bucindolol</a></li> <li><a href="/wiki/Bucumolol" title="Bucumolol">Bucumolol</a></li> <li><a href="/wiki/Bufetolol" title="Bufetolol">Bufetolol</a></li> <li><a href="/wiki/Bufuralol" title="Bufuralol">Bufuralol</a></li> <li><a href="/wiki/Bunitrolol" title="Bunitrolol">Bunitrolol</a></li> <li><a href="/wiki/Bunolol" class="mw-redirect" title="Bunolol">Bunolol</a></li> <li><a href="/wiki/Bupranolol" title="Bupranolol">Bupranolol</a></li> <li><a href="/wiki/Butaxamine" title="Butaxamine">Butaxamine</a></li> <li><a href="/wiki/Butidrine" title="Butidrine">Butidrine</a></li> <li><a href="/wiki/Butofilolol" title="Butofilolol">Butofilolol</a></li> <li><a href="/wiki/Capsinolol" title="Capsinolol">Capsinolol</a></li> <li><a href="/wiki/Carazolol" title="Carazolol">Carazolol</a></li> <li><a href="/wiki/Carpindolol" title="Carpindolol">Carpindolol</a></li> <li><a href="/wiki/Carteolol" title="Carteolol">Carteolol</a></li> <li><a href="/wiki/Carvedilol" title="Carvedilol">Carvedilol</a></li> <li><a href="/wiki/Celiprolol" title="Celiprolol">Celiprolol</a></li> <li><a href="/wiki/Cetamolol" title="Cetamolol">Cetamolol</a></li> <li><a href="/wiki/Cicloprolol" title="Cicloprolol">Cicloprolol</a></li> <li><a href="/wiki/Cinamolol" title="Cinamolol">Cinamolol</a></li> <li><a href="/wiki/Cloranolol" title="Cloranolol">Cloranolol</a></li> <li><a href="/wiki/Cyanopindolol" title="Cyanopindolol">Cyanopindolol</a></li> <li><a href="/wiki/Dalbraminol" title="Dalbraminol">Dalbraminol</a></li> <li><a href="/wiki/Dexpropranolol" class="mw-redirect" title="Dexpropranolol">Dexpropranolol</a></li> <li><a href="/wiki/Diacetolol" title="Diacetolol">Diacetolol</a></li> <li><a href="/wiki/Dichloroisoprenaline" title="Dichloroisoprenaline">Dichloroisoprenaline</a></li> <li><a href="/wiki/Dihydroalprenolol" title="Dihydroalprenolol">Dihydroalprenolol</a></li> <li><a href="/wiki/Dilevalol" class="mw-redirect" title="Dilevalol">Dilevalol</a></li> <li><a href="/wiki/Diprafenone" title="Diprafenone">Diprafenone</a></li> <li><a href="/wiki/Draquinolol" title="Draquinolol">Draquinolol</a></li> <li><a href="/wiki/Ecastolol" title="Ecastolol">Ecastolol</a></li> <li><a href="/wiki/Epanolol" title="Epanolol">Epanolol</a></li> <li><a href="/wiki/Ericolol" title="Ericolol">Ericolol</a></li> <li><a href="/wiki/Ersentilide" title="Ersentilide">Ersentilide</a></li> <li><a href="/wiki/Esatenolol" class="mw-redirect" title="Esatenolol">Esatenolol</a></li> <li><a href="/wiki/Esprolol" class="mw-redirect" title="Esprolol">Esprolol</a></li> <li><a href="/wiki/Eugenodilol" title="Eugenodilol">Eugenodilol</a></li> <li><a href="/wiki/Exaprolol" title="Exaprolol">Exaprolol</a></li> <li><a href="/wiki/Falintolol" title="Falintolol">Falintolol</a></li> <li><a href="/wiki/Flestolol" title="Flestolol">Flestolol</a></li> <li><a href="/wiki/Flusoxolol" title="Flusoxolol">Flusoxolol</a></li> <li><a href="/wiki/Hydroxycarteolol" title="Hydroxycarteolol">Hydroxycarteolol</a></li> <li><a href="/wiki/Hydroxytertatolol" title="Hydroxytertatolol">Hydroxytertatolol</a></li> <li><a href="/wiki/ICI-118,551" title="ICI-118,551">ICI-118,551</a></li> <li><a href="/wiki/Idropranolol" class="mw-redirect" title="Idropranolol">Idropranolol</a></li> <li><a href="/wiki/Indenolol" title="Indenolol">Indenolol</a></li> <li><a href="/wiki/Indopanolol" title="Indopanolol">Indopanolol</a></li> <li><a href="/wiki/Iodocyanopindolol" title="Iodocyanopindolol">Iodocyanopindolol</a></li> <li><a href="/wiki/Iprocrolol" title="Iprocrolol">Iprocrolol</a></li> <li><a href="/wiki/Isoxaprolol" title="Isoxaprolol">Isoxaprolol</a></li> <li><a href="/wiki/Isamoltane" title="Isamoltane">Isamoltane</a></li> <li><a href="/wiki/Labetalol" title="Labetalol">Labetalol</a></li> <li><a href="/wiki/Landiolol" title="Landiolol">Landiolol</a></li> <li><a href="/wiki/Levobetaxolol" title="Levobetaxolol">Levobetaxolol</a></li> <li><a href="/wiki/Levobunolol" title="Levobunolol">Levobunolol</a></li> <li><a href="/wiki/Levomoprolol" title="Levomoprolol">Levomoprolol</a></li> <li><a href="/wiki/Medroxalol" title="Medroxalol">Medroxalol</a></li> <li><a href="/wiki/Mepindolol" title="Mepindolol">Mepindolol</a></li> <li><a href="/wiki/Metipranolol" title="Metipranolol">Metipranolol</a></li> <li><a href="/wiki/Metoprolol" title="Metoprolol">Metoprolol</a></li> <li><a href="/wiki/Moprolol" title="Moprolol">Moprolol</a></li> <li><a href="/wiki/Nadolol" title="Nadolol">Nadolol</a></li> <li><a href="/wiki/Nadoxolol" title="Nadoxolol">Nadoxolol</a></li> <li><a href="/wiki/Nebivolol" title="Nebivolol">Nebivolol</a></li> <li><a href="/wiki/Nifenalol" title="Nifenalol">Nifenalol</a></li> <li><a href="/wiki/Nipradilol" title="Nipradilol">Nipradilol</a></li> <li><a href="/wiki/Oxprenolol" title="Oxprenolol">Oxprenolol</a></li> <li><a href="/wiki/Pacrinolol" title="Pacrinolol">Pacrinolol</a></li> <li><a href="/wiki/Pafenolol" title="Pafenolol">Pafenolol</a></li> <li><a href="/wiki/Pamatolol" title="Pamatolol">Pamatolol</a></li> <li><a href="/wiki/Pargolol" title="Pargolol">Pargolol</a></li> <li><a href="/wiki/Penbutolol" title="Penbutolol">Penbutolol</a></li> <li><a href="/wiki/Pindolol" title="Pindolol">Pindolol</a></li> <li><a href="/wiki/Practolol" title="Practolol">Practolol</a></li> <li><a href="/wiki/Primidolol" title="Primidolol">Primidolol</a></li> <li><a href="/wiki/Procinolol" title="Procinolol">Procinolol</a></li> <li><a href="/wiki/Pronethalol" title="Pronethalol">Pronethalol</a></li> <li><a href="/wiki/Propafenone" title="Propafenone">Propafenone</a></li> <li><a href="/wiki/Propranolol" title="Propranolol">Propranolol</a></li> <li><a href="/wiki/Ridazolol" title="Ridazolol">Ridazolol</a></li> <li><a href="/wiki/Ronactolol" title="Ronactolol">Ronactolol</a></li> <li><a href="/wiki/Soquinolol" title="Soquinolol">Soquinolol</a></li> <li><a href="/wiki/Sotalol" title="Sotalol">Sotalol</a></li> <li><a href="/wiki/Spirendolol" title="Spirendolol">Spirendolol</a></li> <li><a href="/wiki/SR_59230A" title="SR 59230A">SR 59230A</a></li> <li><a href="/wiki/Sulfinalol" title="Sulfinalol">Sulfinalol</a></li> <li><a href="/wiki/Talinolol" title="Talinolol">Talinolol</a></li> <li><a href="/wiki/Tazolol" title="Tazolol">Tazolol</a></li> <li><a href="/wiki/Tertatolol" title="Tertatolol">Tertatolol</a></li> <li><a href="/wiki/Tienoxolol" title="Tienoxolol">Tienoxolol</a></li> <li><a href="/wiki/Tilisolol" title="Tilisolol">Tilisolol</a></li> <li><a href="/wiki/Timolol" title="Timolol">Timolol</a></li> <li><a href="/wiki/Tiprenolol" title="Tiprenolol">Tiprenolol</a></li> <li><a href="/wiki/Tolamolol" title="Tolamolol">Tolamolol</a></li> <li><a href="/wiki/Toliprolol" title="Toliprolol">Toliprolol</a></li> <li><a href="/wiki/Xibenolol" title="Xibenolol">Xibenolol</a></li> <li><a href="/wiki/Xipranolol" title="Xipranolol">Xipranolol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></i></li> <li><i><a href="/wiki/Template:Dopamine_receptor_modulators" title="Template:Dopamine receptor modulators">Dopaminergics</a></i></li> <li><i><a href="/wiki/Template:Serotonin_receptor_modulators" title="Template:Serotonin receptor modulators">Serotonergics</a></i></li> <li><i><a href="/wiki/Template:Monoamine_reuptake_inhibitors" title="Template:Monoamine reuptake inhibitors">Monoamine reuptake inhibitors</a></i></li> <li><i><a href="/wiki/Template:Monoamine_releasing_agents" title="Template:Monoamine releasing agents">Monoamine releasing agents</a></i></li> <li><i><a href="/wiki/Template:Monoamine_metabolism_modulators" title="Template:Monoamine metabolism modulators">Monoamine metabolism modulators</a></i></li> <li><i><a href="/wiki/Template:Monoamine_neurotoxins" title="Template:Monoamine neurotoxins">Monoamine neurotoxins</a></i></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="AstraZeneca" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:AstraZeneca" title="Template:AstraZeneca"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:AstraZeneca" title="Template talk:AstraZeneca"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:AstraZeneca" title="Special:EditPage/Template:AstraZeneca"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="AstraZeneca" style="font-size:114%;margin:0 4em"><a href="/wiki/AstraZeneca" title="AstraZeneca">AstraZeneca</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Products</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acalabrutinib" title="Acalabrutinib">Acalabrutinib</a></li> <li><a href="/wiki/Anastrozole" title="Anastrozole">Anastrozole</a></li> <li><a href="/wiki/Andexanet_alfa" title="Andexanet alfa">Andexanet alfa</a></li> <li><a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Asfotase_alfa" title="Asfotase alfa">Asfotase alfa</a></li> <li><a class="mw-selflink selflink">Atenolol</a></li> <li><a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Bicalutamide" title="Bicalutamide">Bicalutamide</a></li> <li><a href="/wiki/Brompheniramine" title="Brompheniramine">Brompheniramine</a></li> <li><a href="/wiki/Budesonide" title="Budesonide">Budesonide</a></li> <li><a href="/wiki/Budesonide/formoterol" title="Budesonide/formoterol">Budesonide/formoterol</a></li> <li><a href="/wiki/Budesonide/glycopyrronium_bromide/formoterol" title="Budesonide/glycopyrronium bromide/formoterol">Budesonide/glycopyrronium bromide/formoterol</a></li> <li><a href="/wiki/Candesartan" title="Candesartan">Candesartan</a></li> <li><a href="/wiki/Dapagliflozin" title="Dapagliflozin">Dapagliflozin</a></li> <li><a href="/wiki/Disufenton_sodium" title="Disufenton sodium">Disufenton sodium</a></li> <li><a href="/wiki/Durvalumab" title="Durvalumab">Durvalumab</a></li> <li><a href="/wiki/Eculizumab" title="Eculizumab">Eculizumab</a></li> <li><a href="/wiki/Esomeprazole" title="Esomeprazole">Esomeprazole</a></li> <li><a href="/wiki/Exenatide" title="Exenatide">Exenatide</a></li> <li><a href="/wiki/Live_attenuated_influenza_vaccine" title="Live attenuated influenza vaccine">FluMist</a></li> <li><a href="/wiki/Fulvestrant" title="Fulvestrant">Fulvestrant</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Glycopyrronium_bromide/formoterol" title="Glycopyrronium bromide/formoterol">Glycopyrronium bromide/formoterol</a></li> <li><a href="/wiki/Goserelin" title="Goserelin">Goserelin</a></li> <li><a href="/wiki/Isosorbide_mononitrate" title="Isosorbide mononitrate">Isosorbide mononitrate</a></li> <li><a href="/wiki/Metoprolol" title="Metoprolol">Metoprolol</a></li> <li><a href="/wiki/Motavizumab" title="Motavizumab">Motavizumab</a></li> <li><a href="/wiki/Olaparib" title="Olaparib">Olaparib</a></li> <li><a href="/wiki/Omeprazole" title="Omeprazole">Omeprazole</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Palivizumab" title="Palivizumab">Palivizumab</a></li> <li><a href="/wiki/Propofol" title="Propofol">Propofol</a></li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Ravulizumab" title="Ravulizumab">Ravulizumab</a></li> <li><a href="/wiki/Roflumilast" title="Roflumilast">Roflumilast</a></li> <li><a href="/wiki/Rosuvastatin" title="Rosuvastatin">Rosuvastatin</a></li> <li><a href="/wiki/Roxadustat" title="Roxadustat">Roxadustat</a></li> <li><a href="/wiki/Salbutamol/budesonide" title="Salbutamol/budesonide">Salbutamol/budesonide</a></li> <li><a href="/wiki/Savolitinib" title="Savolitinib">Savolitinib</a></li> <li><a href="/wiki/Saxagliptin" title="Saxagliptin">Saxagliptin</a></li> <li><a href="/wiki/Sebelipase_alfa" title="Sebelipase alfa">Sebelipase alfa</a></li> <li><a href="/wiki/Selumetinib" title="Selumetinib">Selumetinib</a></li> <li><a href="/wiki/Sodium_zirconium_cyclosilicate" title="Sodium zirconium cyclosilicate">Sodium zirconium cyclosilicate</a></li> <li><a href="/wiki/Tamoxifen" title="Tamoxifen">Tamoxifen</a></li> <li><a href="/wiki/Ticagrelor" title="Ticagrelor">Ticagrelor</a></li> <li><a href="/wiki/Tixagevimab/cilgavimab" title="Tixagevimab/cilgavimab">Tixagevimab/cilgavimab</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/wiki/Oxford%E2%80%93AstraZeneca_COVID-19_vaccine" title="Oxford–AstraZeneca COVID-19 vaccine">Vaxzevria</a></li> <li><a href="/wiki/Ximelagatran" title="Ximelagatran">Ximelagatran</a></li> <li><a href="/wiki/Zafirlukast" title="Zafirlukast">Zafirlukast</a></li> <li><a href="/wiki/Zolmitriptan" title="Zolmitriptan">Zolmitriptan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Predecessors and<br />acquired companies</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Astra_AB" title="Astra AB">Astra AB</a></li> <li><a href="/wiki/Alexion_Pharmaceuticals" title="Alexion Pharmaceuticals">Alexion Pharmaceuticals</a></li> <li><a href="/wiki/Cambridge_Antibody_Technology" title="Cambridge Antibody Technology">Cambridge Antibody Technology</a></li> <li><a href="/wiki/MedImmune" title="MedImmune">MedImmune</a></li> <li><a href="/wiki/Zeneca" title="Zeneca">Zeneca</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tom_McKillop" title="Tom McKillop">Tom McKillop</a></li> <li><a href="/wiki/Louis_Schweitzer_(CEO)" class="mw-redirect" title="Louis Schweitzer (CEO)">Louis Schweitzer</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="font-weight: bold;"><div> <ul><li><span class="noviewer" typeof="mw:File"><span title="Category"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/16px-Symbol_category_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" 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