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data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2599" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" 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disability","created_at":"2016-05-16T08:10:57.282-07:00","url":"https://www.academia.edu/25365548/The_Dysphagia_Disorder_Survey_Validation_of_an_assessment_for_swallowing_and_feeding_function_in_developmental_disability?f_ri=43363","dom_id":"work_25365548","summary":null,"downloadable_attachments":[{"id":45670894,"asset_id":25365548,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":48800859,"first_name":"Justine Joan","last_name":"Sheppard","domain_name":"independent","page_name":"JustineJoanSheppard","display_name":"Justine Joan Sheppard","profile_url":"https://independent.academia.edu/JustineJoanSheppard?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=43363","nofollow":true},{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=43363","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true},{"id":23868,"name":"Intellectual Disability","url":"https://www.academia.edu/Documents/in/Intellectual_Disability?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=43363"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=43363"},{"id":137145,"name":"Developmental disabilities","url":"https://www.academia.edu/Documents/in/Developmental_disabilities?f_ri=43363"},{"id":218820,"name":"Eating","url":"https://www.academia.edu/Documents/in/Eating?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=43363"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75778399" data-work_id="75778399" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75778399/Effectiveness_of_Semmes_Weinstein_monofilament_examination_for_diabetic_peripheral_neuropathy_screening_in_Ahvaz_Iran">Effectiveness of Semmes–Weinstein monofilament examination for diabetic peripheral neuropathy screening in Ahvaz, Iran</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Abstract: Foot care prevention programs can reduce the occurrence of foot ulcerations and amputations. This investigation evaluated Effectiveness of Semmes–Weinstein monofilament examination for diabetic peripheral neuropathy screening in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75778399" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Abstract: Foot care prevention programs can reduce the occurrence of foot ulcerations and amputations. This investigation evaluated Effectiveness of Semmes–Weinstein monofilament examination for diabetic peripheral neuropathy screening in Ahvaz, Iran. In this quasi-experimental design 150 patients with diabetes mellitus were recruited by purposive sampling. All patients were tested for sensory neuropathy using Semmes-Weinstein Monofilament Examination. In the next phase nerve conduction velocity was examined. The sensitivity of Semmes-Weinstein Monofilament 10 g was 38.5-61.5 % at sites 1-8, whereas the specificity was 77.5-95.5%. Monofilament was found to be simple, cheap and useful method and suitable for detection of sensory neuropathy in clinical examinations. Hence, we recommend screening of patients for neuropathy as soon as they are diagnosed with diabetes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75778399" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1236358c8bf02d71ecb46c86ec3aee2c" rel="nofollow" data-download="{"attachment_id":83414318,"asset_id":75778399,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83414318/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50869801" href="https://independent.academia.edu/MostafaJavadi2">Mostafa Javadi</a><script data-card-contents-for-user="50869801" type="text/json">{"id":50869801,"first_name":"Mostafa","last_name":"Javadi","domain_name":"independent","page_name":"MostafaJavadi2","display_name":"Mostafa Javadi","profile_url":"https://independent.academia.edu/MostafaJavadi2?f_ri=43363","photo":"https://0.academia-photos.com/50869801/15607762/16186047/s65_mostafa.javadi.jpg"}</script></span></span></li><li class="js-paper-rank-work_75778399 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75778399"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75778399, container: ".js-paper-rank-work_75778399", }); 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$(".js-view-count[data-work-id=75778399]").text(description); $(".js-view-count-work_75778399").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75778399").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75778399"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4581" rel="nofollow" href="https://www.academia.edu/Documents/in/Diabetes">Diabetes</a>, <script data-card-contents-for-ri="4581" type="text/json">{"id":4581,"name":"Diabetes","url":"https://www.academia.edu/Documents/in/Diabetes?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41274" rel="nofollow" href="https://www.academia.edu/Documents/in/Iran">Iran</a>, <script data-card-contents-for-ri="41274" type="text/json">{"id":41274,"name":"Iran","url":"https://www.academia.edu/Documents/in/Iran?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75778399]'), work: {"id":75778399,"title":"Effectiveness of Semmes–Weinstein monofilament examination for diabetic peripheral neuropathy screening in Ahvaz, Iran","created_at":"2022-04-07T22:25:52.621-07:00","url":"https://www.academia.edu/75778399/Effectiveness_of_Semmes_Weinstein_monofilament_examination_for_diabetic_peripheral_neuropathy_screening_in_Ahvaz_Iran?f_ri=43363","dom_id":"work_75778399","summary":"Abstract: Foot care prevention programs can reduce the occurrence of foot ulcerations and amputations. This investigation evaluated Effectiveness of Semmes–Weinstein monofilament examination for diabetic peripheral neuropathy screening in Ahvaz, Iran. In this quasi-experimental design 150 patients with diabetes mellitus were recruited by purposive sampling. All patients were tested for sensory neuropathy using Semmes-Weinstein Monofilament Examination. In the next phase nerve conduction velocity was examined. The sensitivity of Semmes-Weinstein Monofilament 10 g was 38.5-61.5 % at sites 1-8, whereas the specificity was 77.5-95.5%. Monofilament was found to be simple, cheap and useful method and suitable for detection of sensory neuropathy in clinical examinations. Hence, we recommend screening of patients for neuropathy as soon as they are diagnosed with diabetes.","downloadable_attachments":[{"id":83414318,"asset_id":75778399,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":50869801,"first_name":"Mostafa","last_name":"Javadi","domain_name":"independent","page_name":"MostafaJavadi2","display_name":"Mostafa Javadi","profile_url":"https://independent.academia.edu/MostafaJavadi2?f_ri=43363","photo":"https://0.academia-photos.com/50869801/15607762/16186047/s65_mostafa.javadi.jpg"}],"research_interests":[{"id":4581,"name":"Diabetes","url":"https://www.academia.edu/Documents/in/Diabetes?f_ri=43363","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363","nofollow":true},{"id":41274,"name":"Iran","url":"https://www.academia.edu/Documents/in/Iran?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":1292776,"name":"Nerve Conduction Velocity","url":"https://www.academia.edu/Documents/in/Nerve_Conduction_Velocity?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_60513719" data-work_id="60513719" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/60513719/Target_Identification_A_Challenging_Step_in_Forward_Chemical_Genetics">Target Identification : A Challenging Step in Forward Chemical Genetics</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_60513719" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or proteins. To validate the applicability of their novel ideas, various approaches are built up. To date, the most promising and commonly used approach for discovering the target proteins from biological system using small molecule is well known a forward chemical genetics which is considered to be more convenient than the classical genetics. Although, the forward chemical genetics consists of the three basic components, the target identification is the most challenging step to chemical biology researchers. Hence, the diverse target identification methods have been developed and adopted to disclose the small molecule bound protein. Herein, in this review, we briefly described the first two parts chemical toolbox and screening, and then the t...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/60513719" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="97f0f55f0573a340457e3d72ac595a3d" rel="nofollow" data-download="{"attachment_id":73924994,"asset_id":60513719,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73924994/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="114164148" href="https://independent.academia.edu/SuDongdong">Su Dongdong</a><script data-card-contents-for-user="114164148" type="text/json">{"id":114164148,"first_name":"Su","last_name":"Dongdong","domain_name":"independent","page_name":"SuDongdong","display_name":"Su Dongdong","profile_url":"https://independent.academia.edu/SuDongdong?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_60513719 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="60513719"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 60513719, container: ".js-paper-rank-work_60513719", }); 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Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or proteins. To validate the applicability of their novel ideas, various approaches are built up. To date, the most promising and commonly used approach for discovering the target proteins from biological system using small molecule is well known a forward chemical genetics which is considered to be more convenient than the classical genetics. Although, the forward chemical genetics consists of the three basic components, the target identification is the most challenging step to chemical biology researchers. Hence, the diverse target identification methods have been developed and adopted to disclose the small molecule bound protein. Herein, in this review, we briefly described the first two parts chemical toolbox and screening, and then the t...","downloadable_attachments":[{"id":73924994,"asset_id":60513719,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":114164148,"first_name":"Su","last_name":"Dongdong","domain_name":"independent","page_name":"SuDongdong","display_name":"Su Dongdong","profile_url":"https://independent.academia.edu/SuDongdong?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":130539,"name":"IBC","url":"https://www.academia.edu/Documents/in/IBC?f_ri=43363","nofollow":true},{"id":393697,"name":"Small Molecules","url":"https://www.academia.edu/Documents/in/Small_Molecules?f_ri=43363","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_58063075" data-work_id="58063075" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58063075/Pre_clinical_pharmacokinetics_and_anti_chlamydial_activity_of_salicylidene_acylhydrazide_inhibitors_of_bacterial_type_III_secretion">Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Salicylidene acylhydrazides belong to a class of compounds shown to inhibit bacterial type III secretion (T3S) in pathogenic Gram-negative bacteria. This class of compounds also inhibits growth and replication of Chlamydiae, strict... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_58063075" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Salicylidene acylhydrazides belong to a class of compounds shown to inhibit bacterial type III secretion (T3S) in pathogenic Gram-negative bacteria. This class of compounds also inhibits growth and replication of Chlamydiae, strict intracellular bacteria that possess a T3S system. In this study a library of 58 salicylidene acylhydrazides was screened to identify inhibitors of Chlamydia growth. Compounds inhibiting growth of both Chlamydia trachomatis and Chlamydophila pneumoniae were tested for cell toxicity and seven compounds were selected for preliminary pharmacokinetic analysis in mice using cassette dosing. Two compounds, ME0177 and ME0192, were further investigated by individual pharmacokinetic analysis. Compound ME0177 had a relatively high peak plasma concentration (C max) and area under curve and therefore may be considered for systemic treatment of Chlamydia infections. The other compound, ME0192, had poor pharmacokinetic properties but the highest anti-chlamydial activity in vitro and therefore was tested for topical treatment in a mouse vaginal infection model. ME0192 administered vaginally significantly reduced the infectious burden of C. trachomatis and the number of infected mice.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58063075" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ad13abfecbda77eb1af1bbbb5706720a" rel="nofollow" data-download="{"attachment_id":72657764,"asset_id":58063075,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72657764/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="160423830" href="https://qau.academia.edu/TofeeqUrRehman">Tofeeq Ur Rehman</a><script data-card-contents-for-user="160423830" type="text/json">{"id":160423830,"first_name":"Tofeeq","last_name":"Ur Rehman","domain_name":"qau","page_name":"TofeeqUrRehman","display_name":"Tofeeq Ur Rehman","profile_url":"https://qau.academia.edu/TofeeqUrRehman?f_ri=43363","photo":"https://0.academia-photos.com/160423830/145676184/135210980/s65_tofeeq.ur_rehman.png"}</script></span></span></li><li class="js-paper-rank-work_58063075 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58063075"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58063075, container: ".js-paper-rank-work_58063075", }); 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This class of compounds also inhibits growth and replication of Chlamydiae, strict intracellular bacteria that possess a T3S system. In this study a library of 58 salicylidene acylhydrazides was screened to identify inhibitors of Chlamydia growth. Compounds inhibiting growth of both Chlamydia trachomatis and Chlamydophila pneumoniae were tested for cell toxicity and seven compounds were selected for preliminary pharmacokinetic analysis in mice using cassette dosing. Two compounds, ME0177 and ME0192, were further investigated by individual pharmacokinetic analysis. Compound ME0177 had a relatively high peak plasma concentration (C max) and area under curve and therefore may be considered for systemic treatment of Chlamydia infections. The other compound, ME0192, had poor pharmacokinetic properties but the highest anti-chlamydial activity in vitro and therefore was tested for topical treatment in a mouse vaginal infection model. ME0192 administered vaginally significantly reduced the infectious burden of C. trachomatis and the number of infected mice.","downloadable_attachments":[{"id":72657764,"asset_id":58063075,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":160423830,"first_name":"Tofeeq","last_name":"Ur Rehman","domain_name":"qau","page_name":"TofeeqUrRehman","display_name":"Tofeeq Ur Rehman","profile_url":"https://qau.academia.edu/TofeeqUrRehman?f_ri=43363","photo":"https://0.academia-photos.com/160423830/145676184/135210980/s65_tofeeq.ur_rehman.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true},{"id":2375,"name":"Medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Medicinal_Chemistry?f_ri=43363","nofollow":true},{"id":7076,"name":"Taxonomy","url":"https://www.academia.edu/Documents/in/Taxonomy?f_ri=43363","nofollow":true},{"id":34106,"name":"Chlamydia trachomatis","url":"https://www.academia.edu/Documents/in/Chlamydia_trachomatis?f_ri=43363"},{"id":41745,"name":"Pharmaceutics","url":"https://www.academia.edu/Documents/in/Pharmaceutics?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":43659,"name":"Pharmaceutical 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and other tumor marker determinations in breast cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In this study, 154 healthy volunteers and 76 patients were tested using the anti-malignin antibody in serum (AMAS) test. Of the 154 volunteers, three were AMAS positive. After further examination, two were positive for cancer and one had... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10210437" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In this study, 154 healthy volunteers and 76 patients were tested using the anti-malignin antibody in serum (AMAS) test. Of the 154 volunteers, three were AMAS positive. After further examination, two were positive for cancer and one had a history of ulcerative colitis. Tumor biopsies of 43 suspicious mammography patients revealed that 32 were cancerous and 11 were benign by pathology. For the cancer patients, 31/32 were positive for the AMAS test, while 4/11 of the pathological benign cases were AMAS positive. In comparison to cancer antigen tests, AMAS was more sensitive (97%) in detecting breast cancer than CEA (0%), CA 15-3 (10%), CA 19-5 (5%) or CA 125 (16%) in the same patients. q</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10210437" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5b0e22d00fab88cd51898678f5bd7d77" rel="nofollow" data-download="{"attachment_id":47483820,"asset_id":10210437,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47483820/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="24956901" href="https://independent.academia.edu/JerryThornthwaite">Jerry Thornthwaite</a><script data-card-contents-for-user="24956901" type="text/json">{"id":24956901,"first_name":"Jerry","last_name":"Thornthwaite","domain_name":"independent","page_name":"JerryThornthwaite","display_name":"Jerry Thornthwaite","profile_url":"https://independent.academia.edu/JerryThornthwaite?f_ri=43363","photo":"https://0.academia-photos.com/24956901/6761612/7635931/s65_jerry.thornthwaite.jpg_oh_264f74f0b00b235ed176bda00ce5aae1_oe_55680371___gda___1432836294_a8939e9a86077c102f2b375edee4ff96"}</script></span></span></li><li class="js-paper-rank-work_10210437 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10210437"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10210437, container: ".js-paper-rank-work_10210437", }); 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Of the 154 volunteers, three were AMAS positive. After further examination, two were positive for cancer and one had a history of ulcerative colitis. Tumor biopsies of 43 suspicious mammography patients revealed that 32 were cancerous and 11 were benign by pathology. For the cancer patients, 31/32 were positive for the AMAS test, while 4/11 of the pathological benign cases were AMAS positive. In comparison to cancer antigen tests, AMAS was more sensitive (97%) in detecting breast cancer than CEA (0%), CA 15-3 (10%), CA 19-5 (5%) or CA 125 (16%) in the same patients. q","downloadable_attachments":[{"id":47483820,"asset_id":10210437,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":24956901,"first_name":"Jerry","last_name":"Thornthwaite","domain_name":"independent","page_name":"JerryThornthwaite","display_name":"Jerry Thornthwaite","profile_url":"https://independent.academia.edu/JerryThornthwaite?f_ri=43363","photo":"https://0.academia-photos.com/24956901/6761612/7635931/s65_jerry.thornthwaite.jpg_oh_264f74f0b00b235ed176bda00ce5aae1_oe_55680371___gda___1432836294_a8939e9a86077c102f2b375edee4ff96"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=43363","nofollow":true},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":57926,"name":"CA","url":"https://www.academia.edu/Documents/in/CA?f_ri=43363","nofollow":false},{"id":209590,"name":"Mammography","url":"https://www.academia.edu/Documents/in/Mammography?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=43363"},{"id":973730,"name":"Carcinoembryonic Antigen","url":"https://www.academia.edu/Documents/in/Carcinoembryonic_Antigen?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12525769" data-work_id="12525769" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12525769/Comparison_of_PCR_and_culture_for_screening_of_vancomycin_resistant_Enterococci_highly_disparate_results_for_vanA_and_vanB">Comparison of PCR and culture for screening of vancomycin-resistant Enterococci: highly disparate results for vanA and vanB</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We compared PCR to conventional culture for the detection of vancomycin-resistant enterococci (VRE) in 30,835 rectal samples over a 3-year period. The positive and negative predictive values of vanB PCR were 1.42% and 99.9%, respectively.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12525769" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We compared PCR to conventional culture for the detection of vancomycin-resistant enterococci (VRE) in 30,835 rectal samples over a 3-year period. The positive and negative predictive values of vanB PCR were 1.42% and 99.9%, respectively. A positive vanB result by PCR is poorly predictive and necessitates culture for differentiation of VRE-positive and -negative individuals.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12525769" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f3a33da919a8a282d29ee60157d2053d" rel="nofollow" data-download="{"attachment_id":46115746,"asset_id":12525769,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46115746/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31414531" href="https://mcgill.academia.edu/GeorgeChong">George Chong</a><script data-card-contents-for-user="31414531" type="text/json">{"id":31414531,"first_name":"George","last_name":"Chong","domain_name":"mcgill","page_name":"GeorgeChong","display_name":"George Chong","profile_url":"https://mcgill.academia.edu/GeorgeChong?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12525769 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12525769"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12525769, container: ".js-paper-rank-work_12525769", }); 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$(".js-view-count[data-work-id=12525769]").text(description); $(".js-view-count-work_12525769").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12525769").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12525769"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="159" rel="nofollow" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a>, <script data-card-contents-for-ri="159" type="text/json">{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9108" rel="nofollow" href="https://www.academia.edu/Documents/in/Glycopeptide_Research">Glycopeptide Research</a>, <script data-card-contents-for-ri="9108" type="text/json">{"id":9108,"name":"Glycopeptide Research","url":"https://www.academia.edu/Documents/in/Glycopeptide_Research?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43666" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Microbiology">Clinical Microbiology</a><script data-card-contents-for-ri="43666" type="text/json">{"id":43666,"name":"Clinical Microbiology","url":"https://www.academia.edu/Documents/in/Clinical_Microbiology?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12525769]'), work: {"id":12525769,"title":"Comparison of PCR and culture for screening of vancomycin-resistant Enterococci: highly disparate results for vanA and vanB","created_at":"2015-05-22T06:17:35.761-07:00","url":"https://www.academia.edu/12525769/Comparison_of_PCR_and_culture_for_screening_of_vancomycin_resistant_Enterococci_highly_disparate_results_for_vanA_and_vanB?f_ri=43363","dom_id":"work_12525769","summary":"We compared PCR to conventional culture for the detection of vancomycin-resistant enterococci (VRE) in 30,835 rectal samples over a 3-year period. The positive and negative predictive values of vanB PCR were 1.42% and 99.9%, respectively. A positive vanB result by PCR is poorly predictive and necessitates culture for differentiation of VRE-positive and -negative individuals.","downloadable_attachments":[{"id":46115746,"asset_id":12525769,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31414531,"first_name":"George","last_name":"Chong","domain_name":"mcgill","page_name":"GeorgeChong","display_name":"George Chong","profile_url":"https://mcgill.academia.edu/GeorgeChong?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true},{"id":9108,"name":"Glycopeptide Research","url":"https://www.academia.edu/Documents/in/Glycopeptide_Research?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":43666,"name":"Clinical Microbiology","url":"https://www.academia.edu/Documents/in/Clinical_Microbiology?f_ri=43363","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=43363"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance?f_ri=43363"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical?f_ri=43363"},{"id":102583,"name":"Drug Resistance","url":"https://www.academia.edu/Documents/in/Drug_Resistance?f_ri=43363"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria?f_ri=43363"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction?f_ri=43363"},{"id":233229,"name":"Genes","url":"https://www.academia.edu/Documents/in/Genes?f_ri=43363"},{"id":427784,"name":"Enterococcus","url":"https://www.academia.edu/Documents/in/Enterococcus?f_ri=43363"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=43363"},{"id":957359,"name":"Culture Media","url":"https://www.academia.edu/Documents/in/Culture_Media?f_ri=43363"},{"id":1027732,"name":"Genotypes","url":"https://www.academia.edu/Documents/in/Genotypes?f_ri=43363"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=43363"},{"id":1966411,"name":"Vancomycin resistance","url":"https://www.academia.edu/Documents/in/Vancomycin_resistance?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_77433531" data-work_id="77433531" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/77433531/Higher_Median_Levels_of_Free_%CE%B2_hCG_and_PAPP_A_in_the_First_Trimester_of_Pregnancy_in_a_Chinese_Ethnic_Group">Higher Median Levels of Free β-hCG and PAPP-A in the First Trimester of Pregnancy in a Chinese Ethnic Group</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">in the fi rst trimester, which could not be explained by differences in maternal weight. Adjustment for ethnicity may be necessary for these biochemical markers in a fi rst trimester screening program.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77433531" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="666e23c6037acdc3ff073cb5b1217604" rel="nofollow" data-download="{"attachment_id":84822568,"asset_id":77433531,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84822568/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42992919" href="https://independent.academia.edu/KevinSpencer7">Kevin Spencer</a><script data-card-contents-for-user="42992919" type="text/json">{"id":42992919,"first_name":"Kevin","last_name":"Spencer","domain_name":"independent","page_name":"KevinSpencer7","display_name":"Kevin Spencer","profile_url":"https://independent.academia.edu/KevinSpencer7?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_77433531 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="77433531"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 77433531, container: ".js-paper-rank-work_77433531", }); });</script></li><li class="js-percentile-work_77433531 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 77433531; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_77433531"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_77433531 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="77433531"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77433531; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=77433531]").text(description); $(".js-view-count-work_77433531").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_77433531").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="77433531"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="145" rel="nofollow" href="https://www.academia.edu/Documents/in/Biochemistry">Biochemistry</a>, <script data-card-contents-for-ri="145" type="text/json">{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12108" rel="nofollow" href="https://www.academia.edu/Documents/in/China">China</a>, <script data-card-contents-for-ri="12108" type="text/json">{"id":12108,"name":"China","url":"https://www.academia.edu/Documents/in/China?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37413" rel="nofollow" href="https://www.academia.edu/Documents/in/Down_Syndrome">Down Syndrome</a>, <script data-card-contents-for-ri="37413" type="text/json">{"id":37413,"name":"Down Syndrome","url":"https://www.academia.edu/Documents/in/Down_Syndrome?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=77433531]'), work: {"id":77433531,"title":"Higher Median Levels of Free β-hCG and PAPP-A in the First Trimester of Pregnancy in a Chinese Ethnic Group","created_at":"2022-04-24T02:43:12.369-07:00","url":"https://www.academia.edu/77433531/Higher_Median_Levels_of_Free_%CE%B2_hCG_and_PAPP_A_in_the_First_Trimester_of_Pregnancy_in_a_Chinese_Ethnic_Group?f_ri=43363","dom_id":"work_77433531","summary":"in the fi rst trimester, which could not be explained by differences in maternal weight. Adjustment for ethnicity may be necessary for these biochemical markers in a fi rst trimester screening program.","downloadable_attachments":[{"id":84822568,"asset_id":77433531,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42992919,"first_name":"Kevin","last_name":"Spencer","domain_name":"independent","page_name":"KevinSpencer7","display_name":"Kevin Spencer","profile_url":"https://independent.academia.edu/KevinSpencer7?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry?f_ri=43363","nofollow":true},{"id":12108,"name":"China","url":"https://www.academia.edu/Documents/in/China?f_ri=43363","nofollow":true},{"id":37413,"name":"Down Syndrome","url":"https://www.academia.edu/Documents/in/Down_Syndrome?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=43363"},{"id":85843,"name":"Chinese","url":"https://www.academia.edu/Documents/in/Chinese?f_ri=43363"},{"id":290137,"name":"Chine","url":"https://www.academia.edu/Documents/in/Chine?f_ri=43363"},{"id":413189,"name":"Ethnic Group","url":"https://www.academia.edu/Documents/in/Ethnic_Group?f_ri=43363"},{"id":554768,"name":"Prenatal Diagnosis","url":"https://www.academia.edu/Documents/in/Prenatal_Diagnosis?f_ri=43363"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=43363"},{"id":987472,"name":"Gestation","url":"https://www.academia.edu/Documents/in/Gestation?f_ri=43363"},{"id":1032327,"name":"False Positive Rate","url":"https://www.academia.edu/Documents/in/False_Positive_Rate?f_ri=43363"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_44624448" data-work_id="44624448" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/44624448/Swallowing_Disorder_in_Multiple_Sclerosis_Modified_Version_of_the_Screening_Tool">Swallowing Disorder in Multiple Sclerosis: Modified Version of the Screening Tool</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Abstract: Objective: Dysphagia is commonly encountered in Multiple Sclerosis (MS). It can consequently cause severe complications such as the increased risk of dehydration, malnutrition and aspiration pneumonia that associated with an... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_44624448" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Abstract:  <br />Objective: Dysphagia is commonly encountered in Multiple Sclerosis (MS). It can consequently cause severe complications such as the increased risk of dehydration, malnutrition and aspiration pneumonia that associated with an increased risk of death in the late stages of the disease. These complications can be prevented with an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) is the only questionnaire developed specifically for patients with MS. The aim of the present study was translation and cross-culturally adaptation of DYMUS for the Persian population and estimation of the questionnairechr('39')s reliability and validity. Also, we investigated the frequency and severity of dysphagia in the patients referring to the Tehran MS Society and its association with the course of MS, disease duration, and Expanded Disability Status Scale (EDSS).<br />Materials & Methods: This is a methodological and descriptive-analytic study. The statistical populations consist of the patients with MS referring to the Tehran Multiple Sclerosis Society in 2018. The study sample consisted of 108 patients who were selected through a convenient sampling method. The research instruments consisted of 10-items DYMUS questionnaire (in the first part of the study, translated and its psychometric properties examined), Dysphagia Handicap Index and a demographic information questionnaire. In methodological section, translation and cross-cultural adaptation were fulfilled and the Confirmatory Factor Analysis (CFA) was used to assess the construct validity and to test the goodness-of-fit of the presented model. The association between the DYMUS and Dysphagia Handicap Index (DHI) scores investigated to convergent validity. ‏ The inter-item correlation matrix was calculated to assess the homogeneity of the questionnaire items. Kuder - Richardson (KR-20) was measured to assess the internal consistency of the questionnaire. Also, the test-retest procedure was conducted on the 19 subjects understudy to assess the reliability. Finally, the frequency and severity of dysphagia and its association with the course of MS, disease duration, and EDSS was investigated. KR-20 reliability coefficient, Intraclass Correlation Coefficient (ICC), inter-item correlation matrix, Mann-Whitney U test and rank correlation coefficient or Spearmanchr('39')s were used to inferential statistical analysis.<br />Results: Analysis of the inter-item correlations matrix indicated a positive correlation between all items, exception item 10. Based on the results of the inter-item correlation, item 10 had the lowest correlation coefficient that was deleted from the questionnaire. CFA results confirmed the two-factor model of DYMUS, “dysphagia for solids” and “dysphagia for liquids”, and revealed that the item 10 was minimally contributing to the measurement of "dysphagia of solids" and internal consistency increased after the deletion of this item. Also, the solution of the 9-item Model was the best goodness-of-fit indicator for the sample. The obtained results from the convergent validity indicated a positive significant correlation between the DYMUS and DHI (rs=0.693, P<0.001). A KR-20 reliability coefficient of the DYMUS was 0.856, indicating high internal consistency of the Persian translation of the questionnaire items. Test-retest reliability was excellent with 0.965 value. The results also showed that 65.7% of multiple sclerosis patients had a swallowing disorder. In terms of the dysphagia severity, 25.9% of participants had mild dysphagia, and 39.8% of participants had alarming dysphagia. DYMUS values were significantly correlated with disease duration (rs=0.198, P= 0.040), and EDSS (rs=0.235, P= 0.014) and significantly higher mean scores were observed in the patients with secondary progressive than the other subgroups of multiple sclerosis.<br />Conclusion: The Persian adjusted 9-item questionnaire was demonstrated to be a simple, consistent, valid and reliable tool for the detection of patients who need more specific instrumental evaluations of swallowing. Also, about the dysphagia is very frequent in these patients, it is important that clinicians monitor these patients carefully even in early stages of the disease‏ for early detection and planning a rehabilitation program to the prevention of serious subsequence complications.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/44624448" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a4da6b707d56a71fe9839c24df4bc3ab" rel="nofollow" data-download="{"attachment_id":65092856,"asset_id":44624448,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/65092856/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27374854" href="https://uswr.academia.edu/RehabilitationJournal">Archives of Rehabilitation</a><script data-card-contents-for-user="27374854" type="text/json">{"id":27374854,"first_name":"Archives of","last_name":"Rehabilitation","domain_name":"uswr","page_name":"RehabilitationJournal","display_name":"Archives of Rehabilitation","profile_url":"https://uswr.academia.edu/RehabilitationJournal?f_ri=43363","photo":"https://0.academia-photos.com/27374854/7783926/60752423/s65_archives_of.rehabilitation.png"}</script></span></span></li><li class="js-paper-rank-work_44624448 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="44624448"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 44624448, container: ".js-paper-rank-work_44624448", }); });</script></li><li class="js-percentile-work_44624448 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 44624448; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_44624448"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_44624448 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="44624448"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 44624448; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=44624448]").text(description); $(".js-view-count-work_44624448").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_44624448").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="44624448"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="3097" rel="nofollow" href="https://www.academia.edu/Documents/in/Multiple_sclerosis">Multiple sclerosis</a>, <script data-card-contents-for-ri="3097" type="text/json">{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22290" rel="nofollow" href="https://www.academia.edu/Documents/in/Dysphagia">Dysphagia</a>, <script data-card-contents-for-ri="22290" type="text/json">{"id":22290,"name":"Dysphagia","url":"https://www.academia.edu/Documents/in/Dysphagia?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=44624448]'), work: {"id":44624448,"title":"Swallowing Disorder in Multiple Sclerosis: Modified Version of the Screening Tool","created_at":"2020-12-02T21:06:42.718-08:00","url":"https://www.academia.edu/44624448/Swallowing_Disorder_in_Multiple_Sclerosis_Modified_Version_of_the_Screening_Tool?f_ri=43363","dom_id":"work_44624448","summary":"Abstract: \nObjective: Dysphagia is commonly encountered in Multiple Sclerosis (MS). It can consequently cause severe complications such as the increased risk of dehydration, malnutrition and aspiration pneumonia that associated with an increased risk of death in the late stages of the disease. These complications can be prevented with an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) is the only questionnaire developed specifically for patients with MS. The aim of the present study was translation and cross-culturally adaptation of DYMUS for the Persian population and estimation of the questionnairechr('39')s reliability and validity. Also, we investigated the frequency and severity of dysphagia in the patients referring to the Tehran MS Society and its association with the course of MS, disease duration, and Expanded Disability Status Scale (EDSS).\nMaterials \u0026 Methods: This is a methodological and descriptive-analytic study. The statistical populations consist of the patients with MS referring to the Tehran Multiple Sclerosis Society in 2018. The study sample consisted of 108 patients who were selected through a convenient sampling method. The research instruments consisted of 10-items DYMUS questionnaire (in the first part of the study, translated and its psychometric properties examined), Dysphagia Handicap Index and a demographic information questionnaire. In methodological section, translation and cross-cultural adaptation were fulfilled and the Confirmatory Factor Analysis (CFA) was used to assess the construct validity and to test the goodness-of-fit of the presented model. The association between the DYMUS and Dysphagia Handicap Index (DHI) scores investigated to convergent validity. ‏ The inter-item correlation matrix was calculated to assess the homogeneity of the questionnaire items. Kuder - Richardson (KR-20) was measured to assess the internal consistency of the questionnaire. Also, the test-retest procedure was conducted on the 19 subjects understudy to assess the reliability. Finally, the frequency and severity of dysphagia and its association with the course of MS, disease duration, and EDSS was investigated. KR-20 reliability coefficient, Intraclass Correlation Coefficient (ICC), inter-item correlation matrix, Mann-Whitney U test and rank correlation coefficient or Spearmanchr('39')s were used to inferential statistical analysis.\nResults: Analysis of the inter-item correlations matrix indicated a positive correlation between all items, exception item 10. Based on the results of the inter-item correlation, item 10 had the lowest correlation coefficient that was deleted from the questionnaire. CFA results confirmed the two-factor model of DYMUS, “dysphagia for solids” and “dysphagia for liquids”, and revealed that the item 10 was minimally contributing to the measurement of \"dysphagia of solids\" and internal consistency increased after the deletion of this item. Also, the solution of the 9-item Model was the best goodness-of-fit indicator for the sample. The obtained results from the convergent validity indicated a positive significant correlation between the DYMUS and DHI (rs=0.693, P\u003c0.001). A KR-20 reliability coefficient of the DYMUS was 0.856, indicating high internal consistency of the Persian translation of the questionnaire items. Test-retest reliability was excellent with 0.965 value. The results also showed that 65.7% of multiple sclerosis patients had a swallowing disorder. In terms of the dysphagia severity, 25.9% of participants had mild dysphagia, and 39.8% of participants had alarming dysphagia. DYMUS values were significantly correlated with disease duration (rs=0.198, P= 0.040), and EDSS (rs=0.235, P= 0.014) and significantly higher mean scores were observed in the patients with secondary progressive than the other subgroups of multiple sclerosis.\nConclusion: The Persian adjusted 9-item questionnaire was demonstrated to be a simple, consistent, valid and reliable tool for the detection of patients who need more specific instrumental evaluations of swallowing. Also, about the dysphagia is very frequent in these patients, it is important that clinicians monitor these patients carefully even in early stages of the disease‏ for early detection and planning a rehabilitation program to the prevention of serious subsequence complications.","downloadable_attachments":[{"id":65092856,"asset_id":44624448,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27374854,"first_name":"Archives of","last_name":"Rehabilitation","domain_name":"uswr","page_name":"RehabilitationJournal","display_name":"Archives of Rehabilitation","profile_url":"https://uswr.academia.edu/RehabilitationJournal?f_ri=43363","photo":"https://0.academia-photos.com/27374854/7783926/60752423/s65_archives_of.rehabilitation.png"}],"research_interests":[{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=43363","nofollow":true},{"id":22290,"name":"Dysphagia","url":"https://www.academia.edu/Documents/in/Dysphagia?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7960926 coauthored" data-work_id="7960926" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7960926/A_szem%C3%A9lyis%C3%A9g_%C3%A9s_a_k%C3%A9pess%C3%A9gek_szerepe_az_egyetemi_sikeress%C3%A9gben_avagy_igazolhat%C3%B3_e_a_sz%C5%B1r%C5%91_hipot%C3%A9zis_a_Debreceni_Egyetem_K%C3%B6zgazdas%C3%A1gtudom%C3%A1nyi_Kar%C3%A1nak_hallgat%C3%B3i_k%C3%B6r%C3%A9ben_v%C3%A9gzett_felm%C3%A9r%C3%A9s_alapj%C3%A1n">A személyiség és a képességek szerepe az egyetemi sikerességben - avagy igazolható-e a szűrő hipotézis a Debreceni Egyetem Közgazdaságtudományi Karának hallgatói körében végzett felmérés alapján</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Tanulmányunk azt a kérdést járja körül, hogy milyen befolyással bír a tanulmányi eredmények alakulására az értelmi és érzelmi intelligencia, valamint a személyiségstílus. Mindezt a Debreceni Egyetem közgazdász hallgatói körében végzett... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7960926" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Tanulmányunk azt a kérdést járja körül, hogy milyen befolyással bír a tanulmányi eredmények alakulására az értelmi és érzelmi intelligencia, valamint a személyiségstílus. Mindezt a Debreceni Egyetem közgazdász hallgatói körében végzett felmérések segítségével vizsgáljuk meg. Elemzésünkben főként regresszióanalízisre támaszkodtunk. Az eredmények segítségével két kérdésre kívánunk választ kapni. Egyrészt arra, milyen kapcsolat van az említett változók és a vizsgált szakon való sikeres szereplés közt, másrészt, hogy rendelkezik-e a felsőoktatás tisztán információs (szűrő) funkcióval is, vagy csupán termelékenységet növel. Kapott eredményeink az egyes felmérések esetében némileg eltérnek, de általában elmondhatjuk, hogy az egyetemi eredményességet szignifikánsan befolyásolja a hallgató neme, szüleinek végzettsége, értelmi intelligenciája, intro- vagy extrovertáltsága, gondolkodó vagy észlelő személyiségstílusa, valamint a minták egy részénél érzelmi intelligenciája és észlelő vagy ítélkező személyiségstílusa. Mivel ezek nem mindegyike függ a felsőoktatás hatásától, elmondhatjuk, hogy bizonyítékot találtunk a felsőoktatás szűrő funkciójának jelenlétére. <br />Our study explore the issue of the impact of intelligence, emaotional intelligence, and personality traits on academic success. This was examined with surveys conducted among the economics students of University of Debrecen. Our examination primarily relied on regression analyses. With our findings we aimed to answer to questions. First, what the relationship is between the above mentioned variables and educational achievement in the examined majors, second, if higher education has a clear informational (screening) function or it increases the productivity. Our results are slightly different in each analysis but we can generally state that academic success is significantly affected by the sex, number of graduated parents, intelligence, introversion-extroversion and feeling-thinking personality traits, and in some parts of the samples, emotional intelligence and perceiving-judging personality traits. As not all of these factors depend on the effect of higher education, we can conlcude that we found a proof for the presence of the screening function of higher education.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7960926" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b41e1814da0584a69a87fb0714289330" rel="nofollow" data-download="{"attachment_id":34433464,"asset_id":7960926,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/34433464/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="15171117" href="https://unideb.academia.edu/MariettaKiss">Marietta Kiss</a><script data-card-contents-for-user="15171117" type="text/json">{"id":15171117,"first_name":"Marietta","last_name":"Kiss","domain_name":"unideb","page_name":"MariettaKiss","display_name":"Marietta Kiss","profile_url":"https://unideb.academia.edu/MariettaKiss?f_ri=43363","photo":"https://0.academia-photos.com/15171117/4094552/4773535/s65_marietta.kiss.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-7960926">+1</span><div class="hidden js-additional-users-7960926"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unideb.academia.edu/Andr%C3%A1sKun">András István Kun</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-7960926'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-7960926').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_7960926 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="7960926"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 7960926; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=7960926]").text(description); $(".js-view-count-work_7960926").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_7960926").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7960926"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2672" rel="nofollow" href="https://www.academia.edu/Documents/in/Personality">Personality</a>, <script data-card-contents-for-ri="2672" type="text/json">{"id":2672,"name":"Personality","url":"https://www.academia.edu/Documents/in/Personality?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="14042" rel="nofollow" href="https://www.academia.edu/Documents/in/Human_Capital">Human Capital</a>, <script data-card-contents-for-ri="14042" type="text/json">{"id":14042,"name":"Human Capital","url":"https://www.academia.edu/Documents/in/Human_Capital?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="142985" href="https://www.academia.edu/Documents/in/IQ">IQ</a><script data-card-contents-for-ri="142985" type="text/json">{"id":142985,"name":"IQ","url":"https://www.academia.edu/Documents/in/IQ?f_ri=43363","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7960926]'), work: {"id":7960926,"title":"A személyiség és a képességek szerepe az egyetemi sikerességben - avagy igazolható-e a szűrő hipotézis a Debreceni Egyetem Közgazdaságtudományi Karának hallgatói körében végzett felmérés alapján","created_at":"2014-08-13T04:18:50.603-07:00","url":"https://www.academia.edu/7960926/A_szem%C3%A9lyis%C3%A9g_%C3%A9s_a_k%C3%A9pess%C3%A9gek_szerepe_az_egyetemi_sikeress%C3%A9gben_avagy_igazolhat%C3%B3_e_a_sz%C5%B1r%C5%91_hipot%C3%A9zis_a_Debreceni_Egyetem_K%C3%B6zgazdas%C3%A1gtudom%C3%A1nyi_Kar%C3%A1nak_hallgat%C3%B3i_k%C3%B6r%C3%A9ben_v%C3%A9gzett_felm%C3%A9r%C3%A9s_alapj%C3%A1n?f_ri=43363","dom_id":"work_7960926","summary":"Tanulmányunk azt a kérdést járja körül, hogy milyen befolyással bír a tanulmányi eredmények alakulására az értelmi és érzelmi intelligencia, valamint a személyiségstílus. Mindezt a Debreceni Egyetem közgazdász hallgatói körében végzett felmérések segítségével vizsgáljuk meg. Elemzésünkben főként regresszióanalízisre támaszkodtunk. Az eredmények segítségével két kérdésre kívánunk választ kapni. Egyrészt arra, milyen kapcsolat van az említett változók és a vizsgált szakon való sikeres szereplés közt, másrészt, hogy rendelkezik-e a felsőoktatás tisztán információs (szűrő) funkcióval is, vagy csupán termelékenységet növel. Kapott eredményeink az egyes felmérések esetében némileg eltérnek, de általában elmondhatjuk, hogy az egyetemi eredményességet szignifikánsan befolyásolja a hallgató neme, szüleinek végzettsége, értelmi intelligenciája, intro- vagy extrovertáltsága, gondolkodó vagy észlelő személyiségstílusa, valamint a minták egy részénél érzelmi intelligenciája és észlelő vagy ítélkező személyiségstílusa. Mivel ezek nem mindegyike függ a felsőoktatás hatásától, elmondhatjuk, hogy bizonyítékot találtunk a felsőoktatás szűrő funkciójának jelenlétére.\r\nOur study explore the issue of the impact of intelligence, emaotional intelligence, and personality traits on academic success. This was examined with surveys conducted among the economics students of University of Debrecen. Our examination primarily relied on regression analyses. With our findings we aimed to answer to questions. First, what the relationship is between the above mentioned variables and educational achievement in the examined majors, second, if higher education has a clear informational (screening) function or it increases the productivity. Our results are slightly different in each analysis but we can generally state that academic success is significantly affected by the sex, number of graduated parents, intelligence, introversion-extroversion and feeling-thinking personality traits, and in some parts of the samples, emotional intelligence and perceiving-judging personality traits. As not all of these factors depend on the effect of higher education, we can conlcude that we found a proof for the presence of the screening function of higher education.","downloadable_attachments":[{"id":34433464,"asset_id":7960926,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":15171117,"first_name":"Marietta","last_name":"Kiss","domain_name":"unideb","page_name":"MariettaKiss","display_name":"Marietta Kiss","profile_url":"https://unideb.academia.edu/MariettaKiss?f_ri=43363","photo":"https://0.academia-photos.com/15171117/4094552/4773535/s65_marietta.kiss.jpg"},{"id":5621950,"first_name":"András István","last_name":"Kun","domain_name":"unideb","page_name":"AndrásKun","display_name":"András István Kun","profile_url":"https://unideb.academia.edu/Andr%C3%A1sKun?f_ri=43363","photo":"https://0.academia-photos.com/5621950/4013174/4685763/s65_andr_s_istv_n.kun.jpg"}],"research_interests":[{"id":2672,"name":"Personality","url":"https://www.academia.edu/Documents/in/Personality?f_ri=43363","nofollow":true},{"id":14042,"name":"Human Capital","url":"https://www.academia.edu/Documents/in/Human_Capital?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":142985,"name":"IQ","url":"https://www.academia.edu/Documents/in/IQ?f_ri=43363","nofollow":false},{"id":202128,"name":"EQ","url":"https://www.academia.edu/Documents/in/EQ?f_ri=43363"},{"id":916365,"name":"Emberi Tőke","url":"https://www.academia.edu/Documents/in/Emberi_Toke?f_ri=43363"},{"id":1489836,"name":"Személyiség","url":"https://www.academia.edu/Documents/in/Szemelyiseg?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_69276954" data-work_id="69276954" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/69276954/PSA_use_and_incidence_of_prostate_biopsy_in_the_Tuscany_region_is_opportunistic_screening_discounting_biopsy_in_subjects_with_PSA_elevation">PSA use and incidence of prostate biopsy in the Tuscany region: is opportunistic screening discounting biopsy in subjects with PSA elevation?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Key words: prostate biopsy, prostate cancer, prostate-specific antigen, screening. ... Correspondence to: Stefano Ciatto, CSPO, Viale A. Volta 171, 50131 Florence, Italy. Tel 055-5012275; fax 055-5001623; e-mail <a href="mailto:s.ciatto@cspo.it" rel="nofollow">s.ciatto@cspo.it</a> ... PSA... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69276954" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Key words: prostate biopsy, prostate cancer, prostate-specific antigen, screening. ... Correspondence to: Stefano Ciatto, CSPO, Viale A. Volta 171, 50131 Florence, Italy. Tel 055-5012275; fax 055-5001623; e-mail <a href="mailto:s.ciatto@cspo.it" rel="nofollow">s.ciatto@cspo.it</a> ... PSA use and incidence of prostate biopsy</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69276954" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3a79cb071afecdb89c21c5ef277e6d4f" rel="nofollow" data-download="{"attachment_id":79434265,"asset_id":69276954,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79434265/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46439824" href="https://independent.academia.edu/FrancescoGiusti3">Francesco Giusti</a><script data-card-contents-for-user="46439824" type="text/json">{"id":46439824,"first_name":"Francesco","last_name":"Giusti","domain_name":"independent","page_name":"FrancescoGiusti3","display_name":"Francesco Giusti","profile_url":"https://independent.academia.edu/FrancescoGiusti3?f_ri=43363","photo":"https://0.academia-photos.com/46439824/126360556/115734918/s65_francesco.giusti.png"}</script></span></span></li><li class="js-paper-rank-work_69276954 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69276954"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69276954, container: ".js-paper-rank-work_69276954", }); 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$(".js-view-count[data-work-id=69276954]").text(description); $(".js-view-count-work_69276954").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_69276954").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="69276954"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37826" rel="nofollow" href="https://www.academia.edu/Documents/in/Biopsy">Biopsy</a>, <script data-card-contents-for-ri="37826" type="text/json">{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="45213" rel="nofollow" href="https://www.academia.edu/Documents/in/Italy">Italy</a><script data-card-contents-for-ri="45213" type="text/json">{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=69276954]'), work: {"id":69276954,"title":"PSA use and incidence of prostate biopsy in the Tuscany region: is opportunistic screening discounting biopsy in subjects with PSA elevation?","created_at":"2022-01-23T12:23:38.326-08:00","url":"https://www.academia.edu/69276954/PSA_use_and_incidence_of_prostate_biopsy_in_the_Tuscany_region_is_opportunistic_screening_discounting_biopsy_in_subjects_with_PSA_elevation?f_ri=43363","dom_id":"work_69276954","summary":"Key words: prostate biopsy, prostate cancer, prostate-specific antigen, screening. ... Correspondence to: Stefano Ciatto, CSPO, Viale A. Volta 171, 50131 Florence, Italy. Tel 055-5012275; fax 055-5001623; e-mail s.ciatto@cspo.it ... PSA use and incidence of prostate biopsy","downloadable_attachments":[{"id":79434265,"asset_id":69276954,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46439824,"first_name":"Francesco","last_name":"Giusti","domain_name":"independent","page_name":"FrancescoGiusti3","display_name":"Francesco Giusti","profile_url":"https://independent.academia.edu/FrancescoGiusti3?f_ri=43363","photo":"https://0.academia-photos.com/46439824/126360556/115734918/s65_francesco.giusti.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363","nofollow":true},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=43363","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio?f_ri=43363"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=43363"},{"id":1186440,"name":"Prostate Specific Antigen","url":"https://www.academia.edu/Documents/in/Prostate_Specific_Antigen?f_ri=43363"},{"id":2603607,"name":"Tumori","url":"https://www.academia.edu/Documents/in/Tumori?f_ri=43363"},{"id":3205111,"name":"Prostatic neoplasms","url":"https://www.academia.edu/Documents/in/Prostatic_neoplasms?f_ri=43363"},{"id":3693190,"name":"mass Screening","url":"https://www.academia.edu/Documents/in/mass_Screening?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48163373" data-work_id="48163373" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48163373/Bus_Rapid_Transit_in_New_York_City_Corridor_Evaluation_and_Screening">Bus Rapid Transit in New York City: Corridor Evaluation and Screening</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">... and (b) that any corridor that had scored less than two did not involve a missed BRT opportunity. ... Routes with the largest growth (with development plans factored in) were scored highest; the other routes were scored ... Table 3... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_48163373" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">... and (b) that any corridor that had scored less than two did not involve a missed BRT opportunity. ... Routes with the largest growth (with development plans factored in) were scored highest; the other routes were scored ... Table 3 summarizes potential benefits data for each corridor. ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48163373" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7ae6f0fee4d1bf49a1fbd0a96354830a" rel="nofollow" data-download="{"attachment_id":67542520,"asset_id":48163373,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67542520/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="182235335" href="https://independent.academia.edu/SamuelZImmerman2">Samuel ZImmerman</a><script data-card-contents-for-user="182235335" type="text/json">{"id":182235335,"first_name":"Samuel","last_name":"ZImmerman","domain_name":"independent","page_name":"SamuelZImmerman2","display_name":"Samuel ZImmerman","profile_url":"https://independent.academia.edu/SamuelZImmerman2?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_48163373 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48163373"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48163373, container: ".js-paper-rank-work_48163373", }); 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$(".js-view-count[data-work-id=48163373]").text(description); $(".js-view-count-work_48163373").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48163373").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48163373"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="73" rel="nofollow" href="https://www.academia.edu/Documents/in/Civil_Engineering">Civil Engineering</a>, <script data-card-contents-for-ri="73" type="text/json">{"id":73,"name":"Civil Engineering","url":"https://www.academia.edu/Documents/in/Civil_Engineering?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4808" rel="nofollow" href="https://www.academia.edu/Documents/in/Urban_Planning">Urban Planning</a>, <script data-card-contents-for-ri="4808" type="text/json">{"id":4808,"name":"Urban Planning","url":"https://www.academia.edu/Documents/in/Urban_Planning?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="20436" rel="nofollow" href="https://www.academia.edu/Documents/in/Urban_And_Regional_Planning">Urban And Regional Planning</a>, <script data-card-contents-for-ri="20436" type="text/json">{"id":20436,"name":"Urban And Regional Planning","url":"https://www.academia.edu/Documents/in/Urban_And_Regional_Planning?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="40606" rel="nofollow" href="https://www.academia.edu/Documents/in/Town_planning">Town planning</a><script data-card-contents-for-ri="40606" type="text/json">{"id":40606,"name":"Town planning","url":"https://www.academia.edu/Documents/in/Town_planning?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48163373]'), work: {"id":48163373,"title":"Bus Rapid Transit in New York City: Corridor Evaluation and Screening","created_at":"2021-05-04T02:59:33.396-07:00","url":"https://www.academia.edu/48163373/Bus_Rapid_Transit_in_New_York_City_Corridor_Evaluation_and_Screening?f_ri=43363","dom_id":"work_48163373","summary":"... and (b) that any corridor that had scored less than two did not involve a missed BRT opportunity. ... Routes with the largest growth (with development plans factored in) were scored highest; the other routes were scored ... Table 3 summarizes potential benefits data for each corridor. ...","downloadable_attachments":[{"id":67542520,"asset_id":48163373,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":182235335,"first_name":"Samuel","last_name":"ZImmerman","domain_name":"independent","page_name":"SamuelZImmerman2","display_name":"Samuel ZImmerman","profile_url":"https://independent.academia.edu/SamuelZImmerman2?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":73,"name":"Civil Engineering","url":"https://www.academia.edu/Documents/in/Civil_Engineering?f_ri=43363","nofollow":true},{"id":4808,"name":"Urban Planning","url":"https://www.academia.edu/Documents/in/Urban_Planning?f_ri=43363","nofollow":true},{"id":20436,"name":"Urban And Regional Planning","url":"https://www.academia.edu/Documents/in/Urban_And_Regional_Planning?f_ri=43363","nofollow":true},{"id":40606,"name":"Town planning","url":"https://www.academia.edu/Documents/in/Town_planning?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":47307,"name":"City planning","url":"https://www.academia.edu/Documents/in/City_planning?f_ri=43363"},{"id":68790,"name":"Project evaluation","url":"https://www.academia.edu/Documents/in/Project_evaluation?f_ri=43363"},{"id":70030,"name":"Land Use Planning","url":"https://www.academia.edu/Documents/in/Land_Use_Planning?f_ri=43363"},{"id":74032,"name":"Conceptual Development","url":"https://www.academia.edu/Documents/in/Conceptual_Development?f_ri=43363"},{"id":87786,"name":"New York City","url":"https://www.academia.edu/Documents/in/New_York_City?f_ri=43363"},{"id":97610,"name":"Bus","url":"https://www.academia.edu/Documents/in/Bus?f_ri=43363"},{"id":171500,"name":"Community Planning","url":"https://www.academia.edu/Documents/in/Community_Planning?f_ri=43363"},{"id":238655,"name":"Implementation","url":"https://www.academia.edu/Documents/in/Implementation?f_ri=43363"},{"id":275265,"name":"Bus Rapid Transit","url":"https://www.academia.edu/Documents/in/Bus_Rapid_Transit?f_ri=43363"},{"id":405386,"name":"Record","url":"https://www.academia.edu/Documents/in/Record?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48039218" data-work_id="48039218" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48039218/Outcome_of_a_routine_ultrasound_screening_program_in_a_tertiary_center_in_Australia">Outcome of a routine ultrasound screening program in a tertiary center in Australia</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48039218" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="061bcf33f98de7c1c2e50853244d3d0b" rel="nofollow" data-download="{"attachment_id":66858096,"asset_id":48039218,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66858096/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38687829" href="https://independent.academia.edu/AlecWelsh1">Alec Welsh</a><script data-card-contents-for-user="38687829" type="text/json">{"id":38687829,"first_name":"Alec","last_name":"Welsh","domain_name":"independent","page_name":"AlecWelsh1","display_name":"Alec Welsh","profile_url":"https://independent.academia.edu/AlecWelsh1?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_48039218 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48039218"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48039218, container: ".js-paper-rank-work_48039218", }); });</script></li><li class="js-percentile-work_48039218 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48039218; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48039218"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48039218 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48039218"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48039218; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48039218]").text(description); $(".js-view-count-work_48039218").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48039218").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48039218"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6697" rel="nofollow" href="https://www.academia.edu/Documents/in/Australia">Australia</a>, <script data-card-contents-for-ri="6697" type="text/json">{"id":6697,"name":"Australia","url":"https://www.academia.edu/Documents/in/Australia?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="15639" rel="nofollow" href="https://www.academia.edu/Documents/in/Ultrasound">Ultrasound</a>, <script data-card-contents-for-ri="15639" type="text/json">{"id":15639,"name":"Ultrasound","url":"https://www.academia.edu/Documents/in/Ultrasound?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a><script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48039218]'), work: {"id":48039218,"title":"Outcome of a routine ultrasound screening program in a tertiary center in Australia","created_at":"2021-05-03T23:39:57.021-07:00","url":"https://www.academia.edu/48039218/Outcome_of_a_routine_ultrasound_screening_program_in_a_tertiary_center_in_Australia?f_ri=43363","dom_id":"work_48039218","summary":null,"downloadable_attachments":[{"id":66858096,"asset_id":48039218,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38687829,"first_name":"Alec","last_name":"Welsh","domain_name":"independent","page_name":"AlecWelsh1","display_name":"Alec Welsh","profile_url":"https://independent.academia.edu/AlecWelsh1?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6697,"name":"Australia","url":"https://www.academia.edu/Documents/in/Australia?f_ri=43363","nofollow":true},{"id":15639,"name":"Ultrasound","url":"https://www.academia.edu/Documents/in/Ultrasound?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=43363","nofollow":true},{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics?f_ri=43363"},{"id":674405,"name":"Neural Tube Defects","url":"https://www.academia.edu/Documents/in/Neural_Tube_Defects?f_ri=43363"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=43363"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=43363"},{"id":3499881,"name":"Outcome assessment (Health care)","url":"https://www.academia.edu/Documents/in/Outcome_assessment_Health_care_?f_ri=43363"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47421960" data-work_id="47421960" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47421960/Brief_case_finding_tools_for_anxiety_disorders_Validation_of_GAD_7_and_GAD_2_in_addictions_treatment">Brief case finding tools for anxiety disorders: Validation of GAD-7 and GAD-2 in addictions treatment</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Anxiety disorders are the most common mental health problems and often co-exist with substance use. Little evidence exists to support the use of brief screening tools for anxiety disorders in routine addictions treatment. This... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_47421960" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Anxiety disorders are the most common mental health problems and often co-exist with substance use. Little evidence exists to support the use of brief screening tools for anxiety disorders in routine addictions treatment. This is the first study to test the validity and reliability of GAD-7 and GAD-2 in an outpatient drugs treatment population. Methods: A sample of 103 patients completed brief screening questionnaires and took part in structured diagnostic assessments using CIS-R. A subgroup of 60 patients completed retests after 4 weeks. The results of brief questionnaires were compared to those of gold-standard diagnostic interviews using Receiver Operating Characteristic (ROC) curves. Psychometric properties were also calculated to evaluate the validity and reliability of self-completed questionnaires. Results: A GAD-7 score ≥9 had a sensitivity of 80% and specificity of 86% for any anxiety disorder, also displaying adequate temporal stability at repeated measurements (intra-class correlation = 0.85) and high internal consistency (Cronbach's alpha = 0.91). A GAD-2 score ≥2 had 94% sensitivity and 53% specificity, with adequate internal consistency (0.82). Conclusions: GAD-7 adequately detected the presence of an anxiety disorder in drug and alcohol users; although this study was limited by sample size to determine its reliability for specific diagnoses. Results in this small sample suggest that GAD-7 may be a useful screening tool in addiction services, although replication in a larger sample is warranted.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47421960" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1d24304d33770902c017d83533084396" rel="nofollow" data-download="{"attachment_id":66522161,"asset_id":47421960,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66522161/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32100758" href="https://york.academia.edu/ChristineGodfrey">Christine Godfrey</a><script data-card-contents-for-user="32100758" type="text/json">{"id":32100758,"first_name":"Christine","last_name":"Godfrey","domain_name":"york","page_name":"ChristineGodfrey","display_name":"Christine Godfrey","profile_url":"https://york.academia.edu/ChristineGodfrey?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_47421960 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="47421960"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 47421960, container: ".js-paper-rank-work_47421960", }); });</script></li><li class="js-percentile-work_47421960 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47421960; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_47421960"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_47421960 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="47421960"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47421960; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47421960]").text(description); $(".js-view-count-work_47421960").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_47421960").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="47421960"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1314" rel="nofollow" href="https://www.academia.edu/Documents/in/Anxiety_Disorders">Anxiety Disorders</a>, <script data-card-contents-for-ri="1314" type="text/json">{"id":1314,"name":"Anxiety Disorders","url":"https://www.academia.edu/Documents/in/Anxiety_Disorders?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2483" rel="nofollow" href="https://www.academia.edu/Documents/in/Addiction">Addiction</a>, <script data-card-contents-for-ri="2483" type="text/json">{"id":2483,"name":"Addiction","url":"https://www.academia.edu/Documents/in/Addiction?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2599" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=47421960]'), work: {"id":47421960,"title":"Brief case finding tools for anxiety disorders: Validation of GAD-7 and GAD-2 in addictions treatment","created_at":"2021-04-22T03:31:02.037-07:00","url":"https://www.academia.edu/47421960/Brief_case_finding_tools_for_anxiety_disorders_Validation_of_GAD_7_and_GAD_2_in_addictions_treatment?f_ri=43363","dom_id":"work_47421960","summary":"Background: Anxiety disorders are the most common mental health problems and often co-exist with substance use. Little evidence exists to support the use of brief screening tools for anxiety disorders in routine addictions treatment. This is the first study to test the validity and reliability of GAD-7 and GAD-2 in an outpatient drugs treatment population. Methods: A sample of 103 patients completed brief screening questionnaires and took part in structured diagnostic assessments using CIS-R. A subgroup of 60 patients completed retests after 4 weeks. The results of brief questionnaires were compared to those of gold-standard diagnostic interviews using Receiver Operating Characteristic (ROC) curves. Psychometric properties were also calculated to evaluate the validity and reliability of self-completed questionnaires. Results: A GAD-7 score ≥9 had a sensitivity of 80% and specificity of 86% for any anxiety disorder, also displaying adequate temporal stability at repeated measurements (intra-class correlation = 0.85) and high internal consistency (Cronbach's alpha = 0.91). A GAD-2 score ≥2 had 94% sensitivity and 53% specificity, with adequate internal consistency (0.82). Conclusions: GAD-7 adequately detected the presence of an anxiety disorder in drug and alcohol users; although this study was limited by sample size to determine its reliability for specific diagnoses. Results in this small sample suggest that GAD-7 may be a useful screening tool in addiction services, although replication in a larger sample is warranted.","downloadable_attachments":[{"id":66522161,"asset_id":47421960,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32100758,"first_name":"Christine","last_name":"Godfrey","domain_name":"york","page_name":"ChristineGodfrey","display_name":"Christine Godfrey","profile_url":"https://york.academia.edu/ChristineGodfrey?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1314,"name":"Anxiety Disorders","url":"https://www.academia.edu/Documents/in/Anxiety_Disorders?f_ri=43363","nofollow":true},{"id":2483,"name":"Addiction","url":"https://www.academia.edu/Documents/in/Addiction?f_ri=43363","nofollow":true},{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":86176,"name":"Alcohol","url":"https://www.academia.edu/Documents/in/Alcohol?f_ri=43363"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve?f_ri=43363"},{"id":323476,"name":"International Classification of Diseases","url":"https://www.academia.edu/Documents/in/International_Classification_of_Diseases?f_ri=43363"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=43363"},{"id":378991,"name":"Outpatients","url":"https://www.academia.edu/Documents/in/Outpatients?f_ri=43363"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=43363"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=43363"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve?f_ri=43363"},{"id":1423077,"name":"Substance-Related Disorders","url":"https://www.academia.edu/Documents/in/Substance-Related_Disorders?f_ri=43363"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=43363"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=43363"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_31955081" data-work_id="31955081" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31955081/Validation_of_the_performance_of_a_GMO_multiplex_screening_assay_based_on_microarray_detection">Validation of the performance of a GMO multiplex screening assay based on microarray detection</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A new screening method for the detection and identification of GMO, based on the use of multiplex PCR followed by microarray, has been developed and is presented. The technology is based on the identification of quite ubiquitous GMO... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_31955081" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A new screening method for the detection and identification of GMO, based on the use of multiplex PCR followed by microarray, has been developed and is presented. The technology is based on the identification of quite ubiquitous GMO genetic target elements first amplified by PCR, followed by direct hybridisation of the amplicons on a predefined microarray (DualChip Ò GMO, Eppendorf, Germany). The validation was performed within the framework of a European project (Co-Extra, contract no 007158) and in collaboration with 12 laboratories specialised in GMO detection. The present study reports the strategy and the results of an ISO complying validation of the method carried out through an inter-laboratory study. Sets of blind samples were provided consisting of DNA reference materials covering all the elements detectable by specific probes present on the array. The GMO concentrations varied from 1% down to 0.045%. In addition, a mixture of two GMO events (0.1% study to test the robustness of the assay in extreme conditions. Data were processed according to ISO 5725 standard. The method was evaluated with predefined performance criteria with respect to the EC CRL method acceptance criteria. The overall method performance met the acceptance criteria; in particular, the results showed that the method is suitable for the detection of the different target elements at 0.1% concentration of GMO with a 95% accuracy rate. This collaborative trial showed that the method can be considered as fit for the purpose of screening with respect to its intra-and inter-laboratory accuracy. The results demonstrated the validity of combining multiplex PCR with array detection as provided by the DualChip Ò GMO (Eppendorf, Germany) for the screening of GMO. The results showed that the technology is robust, practical and suitable as a screening tool.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31955081" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9fef27a759a90559e64f7d37b36f9a81" rel="nofollow" data-download="{"attachment_id":52231332,"asset_id":31955081,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52231332/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="61759031" href="https://independent.academia.edu/MyriamSneyers">Myriam Sneyers</a><script data-card-contents-for-user="61759031" type="text/json">{"id":61759031,"first_name":"Myriam","last_name":"Sneyers","domain_name":"independent","page_name":"MyriamSneyers","display_name":"Myriam Sneyers","profile_url":"https://independent.academia.edu/MyriamSneyers?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_31955081 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31955081"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31955081, container: ".js-paper-rank-work_31955081", }); 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$(".js-view-count[data-work-id=31955081]").text(description); $(".js-view-count-work_31955081").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_31955081").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="31955081"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2513" rel="nofollow" href="https://www.academia.edu/Documents/in/Molecular_Biology">Molecular Biology</a>, <script data-card-contents-for-ri="2513" type="text/json">{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7603" rel="nofollow" href="https://www.academia.edu/Documents/in/Food">Food</a>, <script data-card-contents-for-ri="7603" type="text/json">{"id":7603,"name":"Food","url":"https://www.academia.edu/Documents/in/Food?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9043" rel="nofollow" href="https://www.academia.edu/Documents/in/Performance">Performance</a><script data-card-contents-for-ri="9043" type="text/json">{"id":9043,"name":"Performance","url":"https://www.academia.edu/Documents/in/Performance?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31955081]'), work: {"id":31955081,"title":"Validation of the performance of a GMO multiplex screening assay based on microarray detection","created_at":"2017-03-20T23:15:55.075-07:00","url":"https://www.academia.edu/31955081/Validation_of_the_performance_of_a_GMO_multiplex_screening_assay_based_on_microarray_detection?f_ri=43363","dom_id":"work_31955081","summary":"A new screening method for the detection and identification of GMO, based on the use of multiplex PCR followed by microarray, has been developed and is presented. The technology is based on the identification of quite ubiquitous GMO genetic target elements first amplified by PCR, followed by direct hybridisation of the amplicons on a predefined microarray (DualChip Ò GMO, Eppendorf, Germany). The validation was performed within the framework of a European project (Co-Extra, contract no 007158) and in collaboration with 12 laboratories specialised in GMO detection. The present study reports the strategy and the results of an ISO complying validation of the method carried out through an inter-laboratory study. Sets of blind samples were provided consisting of DNA reference materials covering all the elements detectable by specific probes present on the array. The GMO concentrations varied from 1% down to 0.045%. In addition, a mixture of two GMO events (0.1% study to test the robustness of the assay in extreme conditions. Data were processed according to ISO 5725 standard. The method was evaluated with predefined performance criteria with respect to the EC CRL method acceptance criteria. The overall method performance met the acceptance criteria; in particular, the results showed that the method is suitable for the detection of the different target elements at 0.1% concentration of GMO with a 95% accuracy rate. This collaborative trial showed that the method can be considered as fit for the purpose of screening with respect to its intra-and inter-laboratory accuracy. The results demonstrated the validity of combining multiplex PCR with array detection as provided by the DualChip Ò GMO (Eppendorf, Germany) for the screening of GMO. The results showed that the technology is robust, practical and suitable as a screening tool.","downloadable_attachments":[{"id":52231332,"asset_id":31955081,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":61759031,"first_name":"Myriam","last_name":"Sneyers","domain_name":"independent","page_name":"MyriamSneyers","display_name":"Myriam Sneyers","profile_url":"https://independent.academia.edu/MyriamSneyers?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=43363","nofollow":true},{"id":7603,"name":"Food","url":"https://www.academia.edu/Documents/in/Food?f_ri=43363","nofollow":true},{"id":9043,"name":"Performance","url":"https://www.academia.edu/Documents/in/Performance?f_ri=43363","nofollow":true},{"id":14907,"name":"Industrial Biotechnology","url":"https://www.academia.edu/Documents/in/Industrial_Biotechnology?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":82988,"name":"Microarray","url":"https://www.academia.edu/Documents/in/Microarray?f_ri=43363"},{"id":191520,"name":"multiplex PCR","url":"https://www.academia.edu/Documents/in/multiplex_PCR?f_ri=43363"},{"id":192782,"name":"Laboratory","url":"https://www.academia.edu/Documents/in/Laboratory?f_ri=43363"},{"id":352422,"name":"GMO","url":"https://www.academia.edu/Documents/in/GMO?f_ri=43363"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences?f_ri=43363"},{"id":769412,"name":"Multiplex","url":"https://www.academia.edu/Documents/in/Multiplex?f_ri=43363"},{"id":1346616,"name":"Genetically Modified Organism (GMO)","url":"https://www.academia.edu/Documents/in/Genetically_Modified_Organism_GMO_?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27022342" data-work_id="27022342" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27022342/Plasmodium_falciparum_gametocytaemia_with_chloroquine_chemotherapy_in_persistent_malaria_in_an_endemic_area_of_India">Plasmodium falciparum gametocytaemia with chloroquine chemotherapy in persistent malaria in an endemic area of India</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Gametocyte sex-ratio in Plasmodium falciparum malaria is an important determinant of transmission success and basis of disease epidemiology. Information on ratio of male to female gametocytes after an exposure of antimalarial regimens... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27022342" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Gametocyte sex-ratio in Plasmodium falciparum malaria is an important determinant of transmission success and basis of disease epidemiology. Information on ratio of male to female gametocytes after an exposure of antimalarial regimens under field conditions is very limited. In this retrospective study we observed high densities of gametocytes along with high sex-ratio in P. falciparum cases, which may be responsible for persistent malaria transmission in this area. Laksar PHC of Hardwar district, Uttarakhand State, India was selected because it contributed 90 per cent of the total malaria cases. A total of 568 uncomplicated P. falciparum malaria patients were assessed to investigate prevalence of gametocytes while 339 P. falciparum thick smears containing 5620 gametocytes were screened for measuring the gametocyte density for microgametocyte (male) and macrogametocyte (female). Homology of variance (&#39;F&#39; test) was checked on days 7 and 14 including the variables and risk fact...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27022342" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8271c99fd50671663f23e3e15affd9d2" rel="nofollow" data-download="{"attachment_id":47286043,"asset_id":27022342,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47286043/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51052944" href="https://ruhsraj.academia.edu/AshishGupta">Ashish Gupta</a><script data-card-contents-for-user="51052944" type="text/json">{"id":51052944,"first_name":"Ashish","last_name":"Gupta","domain_name":"ruhsraj","page_name":"AshishGupta","display_name":"Ashish Gupta","profile_url":"https://ruhsraj.academia.edu/AshishGupta?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27022342 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27022342"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27022342, container: ".js-paper-rank-work_27022342", }); 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Information on ratio of male to female gametocytes after an exposure of antimalarial regimens under field conditions is very limited. In this retrospective study we observed high densities of gametocytes along with high sex-ratio in P. falciparum cases, which may be responsible for persistent malaria transmission in this area. Laksar PHC of Hardwar district, Uttarakhand State, India was selected because it contributed 90 per cent of the total malaria cases. A total of 568 uncomplicated P. falciparum malaria patients were assessed to investigate prevalence of gametocytes while 339 P. falciparum thick smears containing 5620 gametocytes were screened for measuring the gametocyte density for microgametocyte (male) and macrogametocyte (female). Homology of variance (\u0026#39;F\u0026#39; test) was checked on days 7 and 14 including the variables and risk fact...","downloadable_attachments":[{"id":47286043,"asset_id":27022342,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51052944,"first_name":"Ashish","last_name":"Gupta","domain_name":"ruhsraj","page_name":"AshishGupta","display_name":"Ashish Gupta","profile_url":"https://ruhsraj.academia.edu/AshishGupta?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=43363","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":43838,"name":"India","url":"https://www.academia.edu/Documents/in/India?f_ri=43363","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=43363"},{"id":90987,"name":"Sex ratio","url":"https://www.academia.edu/Documents/in/Sex_ratio?f_ri=43363"},{"id":102583,"name":"Drug Resistance","url":"https://www.academia.edu/Documents/in/Drug_Resistance?f_ri=43363"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=43363"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=43363"},{"id":135005,"name":"Patient Compliance","url":"https://www.academia.edu/Documents/in/Patient_Compliance?f_ri=43363"},{"id":157932,"name":"Endemic Diseases","url":"https://www.academia.edu/Documents/in/Endemic_Diseases?f_ri=43363"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":454230,"name":"Plasmodium falciparum","url":"https://www.academia.edu/Documents/in/Plasmodium_falciparum?f_ri=43363"},{"id":454707,"name":"Antimalarials","url":"https://www.academia.edu/Documents/in/Antimalarials?f_ri=43363"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=43363"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=43363"},{"id":620661,"name":"High Density Concrete","url":"https://www.academia.edu/Documents/in/High_Density_Concrete?f_ri=43363"},{"id":919274,"name":"Chloroquine","url":"https://www.academia.edu/Documents/in/Chloroquine?f_ri=43363"},{"id":951300,"name":"Female To Male","url":"https://www.academia.edu/Documents/in/Female_To_Male?f_ri=43363"},{"id":990198,"name":"Retrospective Study","url":"https://www.academia.edu/Documents/in/Retrospective_Study?f_ri=43363"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21730012" data-work_id="21730012" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21730012/Development_of_a_widely_applicable_positive_control_strategy_to_support_detection_of_infectious_salmon_anaemia_virus_ISAV_using_Taqman_real_time_PCR">Development of a widely applicable positive control strategy to support detection of infectious salmon anaemia virus (ISAV) using Taqman real-time PCR</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Real-time PCR assays are being increasingly applied to the detection of fish pathogens due to their sensitivity, specificity and potential for high throughput sample processing. Such assays allow for the ready and efficient inclusion of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21730012" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Real-time PCR assays are being increasingly applied to the detection of fish pathogens due to their sensitivity, specificity and potential for high throughput sample processing. Such assays allow for the ready and efficient inclusion of appropriate quality controls which are fundamental to scientific integrity and to satisfying the demands of diagnostic test accreditation. In this article, we report development of a universal positive control strategy for real-time PCR assays, which has been used to support and improve a previously published method for detection of infectious salmon anaemia virus (ISAV). The strategy employed uses an RNA mimic template, which is based on the ISAV segment 8 target sequence but includes an artificial universal positive control sequence. Inclusion of this sequence, which is targeted by a second specific probe carrying a different fluorophore to the primary assay, allows for convenient screening of all real-time PCR reactions for the presence of contaminating positive control material. The development of readily distinguishable artificial positive control material offers distinct advantages to real-time PCR assays over using control material derived from clinical material.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21730012" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="38dd22dab3f5bc8bf59d71230a4fa04a" rel="nofollow" data-download="{"attachment_id":42467120,"asset_id":21730012,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42467120/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42921996" href="https://independent.academia.edu/IMatejusova">I. Matejusova</a><script data-card-contents-for-user="42921996" type="text/json">{"id":42921996,"first_name":"I.","last_name":"Matejusova","domain_name":"independent","page_name":"IMatejusova","display_name":"I. 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Such assays allow for the ready and efficient inclusion of appropriate quality controls which are fundamental to scientific integrity and to satisfying the demands of diagnostic test accreditation. In this article, we report development of a universal positive control strategy for real-time PCR assays, which has been used to support and improve a previously published method for detection of infectious salmon anaemia virus (ISAV). The strategy employed uses an RNA mimic template, which is based on the ISAV segment 8 target sequence but includes an artificial universal positive control sequence. Inclusion of this sequence, which is targeted by a second specific probe carrying a different fluorophore to the primary assay, allows for convenient screening of all real-time PCR reactions for the presence of contaminating positive control material. The development of readily distinguishable artificial positive control material offers distinct advantages to real-time PCR assays over using control material derived from clinical material.","downloadable_attachments":[{"id":42467120,"asset_id":21730012,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42921996,"first_name":"I.","last_name":"Matejusova","domain_name":"independent","page_name":"IMatejusova","display_name":"I. 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The objective of this study is to measure TB suspicion and knowledge among private and public... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21713318" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Early detection of smear positive TB cases by smear microscopy requires high level of suspicion of TB among primary care physicians. The objective of this study is to measure TB suspicion and knowledge among private and public sector general practitioners using clinical vignette-based survey and structured questionnaire.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21713318" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e2645e3efbf2aebcf43c17c549fa09f6" rel="nofollow" data-download="{"attachment_id":42451365,"asset_id":21713318,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42451365/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42811380" href="https://independent.academia.edu/OmaralRawas">Omar Al-Rawas</a><script data-card-contents-for-user="42811380" type="text/json">{"id":42811380,"first_name":"Omar","last_name":"Al-Rawas","domain_name":"independent","page_name":"OmaralRawas","display_name":"Omar Al-Rawas","profile_url":"https://independent.academia.edu/OmaralRawas?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21713318 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21713318"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21713318, container: ".js-paper-rank-work_21713318", }); 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Screening is unproven to enable the detection of more non-muscle-invasive tumors. BC association with aristolochic acid nephropathy (AAN) was reported after intake of slimming pills containing Chinese herbs. Objective: We evaluated whether a BC screening protocol in a high-risk and unique patient population had an impact on the stage of tumor presentation. Design, setting, and participants: Forty-eight AAN-affected patients were enrolled in a screening program, establishing BC incidence during prospective screening cystoscopies and biopsies biannually for up to 10 yr. Two patients were lost to follow-up, and three refused screening after consenting. Measurements: Patients were evaluated for presence of BC and tumor stage at diagnosis. Results and limitations: BC was diagnosed in 25 patients (52%). Among 43 patients who underwent screening cystoscopies (median follow-up: 94 mo), 22 were first diagnosed with non-muscle-invasive BC but none with muscle-invasive tumors and none died of BC. Three women who declined follow-up were diagnosed and died with advanced metastatic disease. The limitations of our findings include the small sample size of this case series, the absence of a real control group, and the particular risk factor in these patients that differs from the usual risk factors, such as smoking or industrial chemicals. Conclusions: BC screening in high-risk groups may allow identification of tumors before muscle invasion. The optimal screening schedule and the relevance of the present findings in smoking-related BC remain to be defined.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20520543" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e26a8a8deaf7ced287a39be5de421873" rel="nofollow" data-download="{"attachment_id":41950163,"asset_id":20520543,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41950163/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41811527" href="https://independent.academia.edu/thierryroumeguere">thierry roumeguere</a><script data-card-contents-for-user="41811527" type="text/json">{"id":41811527,"first_name":"thierry","last_name":"roumeguere","domain_name":"independent","page_name":"thierryroumeguere","display_name":"thierry roumeguere","profile_url":"https://independent.academia.edu/thierryroumeguere?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-20520543">+1</span><div class="hidden js-additional-users-20520543"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/JoelleNortier">Joëlle Nortier</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-20520543'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-20520543').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20520543 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20520543"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20520543; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20520543]").text(description); $(".js-view-count-work_20520543").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20520543").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20520543"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">23</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="622" rel="nofollow" href="https://www.academia.edu/Documents/in/Nephrology">Nephrology</a>, <script data-card-contents-for-ri="622" type="text/json">{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="653" rel="nofollow" href="https://www.academia.edu/Documents/in/Urology">Urology</a>, <script data-card-contents-for-ri="653" type="text/json">{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8863" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_Migration">Cell Migration</a><script data-card-contents-for-ri="8863" type="text/json">{"id":8863,"name":"Cell Migration","url":"https://www.academia.edu/Documents/in/Cell_Migration?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20520543]'), work: {"id":20520543,"title":"Select Screening in a Specific High-Risk Population of Patients Suggests a Stage Migration Toward Detection of Non–Muscle-Invasive Bladder Cancer","created_at":"2016-01-22T04:10:59.487-08:00","url":"https://www.academia.edu/20520543/Select_Screening_in_a_Specific_High_Risk_Population_of_Patients_Suggests_a_Stage_Migration_Toward_Detection_of_Non_Muscle_Invasive_Bladder_Cancer?f_ri=43363","dom_id":"work_20520543","summary":"a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e u r o p e a n u r o l o g y . c o m Abstract Background: More than 25% of bladder cancer (BC) cases are still muscle-invasive at first diagnosis. Screening is unproven to enable the detection of more non-muscle-invasive tumors. BC association with aristolochic acid nephropathy (AAN) was reported after intake of slimming pills containing Chinese herbs. Objective: We evaluated whether a BC screening protocol in a high-risk and unique patient population had an impact on the stage of tumor presentation. Design, setting, and participants: Forty-eight AAN-affected patients were enrolled in a screening program, establishing BC incidence during prospective screening cystoscopies and biopsies biannually for up to 10 yr. Two patients were lost to follow-up, and three refused screening after consenting. Measurements: Patients were evaluated for presence of BC and tumor stage at diagnosis. Results and limitations: BC was diagnosed in 25 patients (52%). Among 43 patients who underwent screening cystoscopies (median follow-up: 94 mo), 22 were first diagnosed with non-muscle-invasive BC but none with muscle-invasive tumors and none died of BC. Three women who declined follow-up were diagnosed and died with advanced metastatic disease. The limitations of our findings include the small sample size of this case series, the absence of a real control group, and the particular risk factor in these patients that differs from the usual risk factors, such as smoking or industrial chemicals. Conclusions: BC screening in high-risk groups may allow identification of tumors before muscle invasion. The optimal screening schedule and the relevance of the present findings in smoking-related BC remain to be defined.","downloadable_attachments":[{"id":41950163,"asset_id":20520543,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41811527,"first_name":"thierry","last_name":"roumeguere","domain_name":"independent","page_name":"thierryroumeguere","display_name":"thierry roumeguere","profile_url":"https://independent.academia.edu/thierryroumeguere?f_ri=43363","photo":"/images/s65_no_pic.png"},{"id":42004571,"first_name":"Joëlle","last_name":"Nortier","domain_name":"independent","page_name":"JoelleNortier","display_name":"Joëlle Nortier","profile_url":"https://independent.academia.edu/JoelleNortier?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=43363","nofollow":true},{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=43363","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=43363","nofollow":true},{"id":8863,"name":"Cell Migration","url":"https://www.academia.edu/Documents/in/Cell_Migration?f_ri=43363","nofollow":true},{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=43363"},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=43363"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":58274,"name":"Bladder Cancer","url":"https://www.academia.edu/Documents/in/Bladder_Cancer?f_ri=43363"},{"id":71469,"name":"Muscle","url":"https://www.academia.edu/Documents/in/Muscle?f_ri=43363"},{"id":174804,"name":"Fibrosis","url":"https://www.academia.edu/Documents/in/Fibrosis?f_ri=43363"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=43363"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=43363"},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy?f_ri=43363"},{"id":371494,"name":"Neoplasm Invasiveness","url":"https://www.academia.edu/Documents/in/Neoplasm_Invasiveness?f_ri=43363"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=43363"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=43363"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=43363"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=43363"},{"id":774352,"name":"Stage","url":"https://www.academia.edu/Documents/in/Stage?f_ri=43363"},{"id":843139,"name":"Cystoscopy","url":"https://www.academia.edu/Documents/in/Cystoscopy?f_ri=43363"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=43363"},{"id":1345117,"name":"Aristolochic Acid","url":"https://www.academia.edu/Documents/in/Aristolochic_Acid?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_58463340" data-work_id="58463340" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58463340/Finding_Dementia_in_Primary_Care_The_Results_of_a_Clinical_Demonstration_Project">Finding Dementia in Primary Care: The Results of a Clinical Demonstration Project</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To assess the effect of screening on diagnosing cognitive impairment. DESIGN: Quality improvement initiative. SETTING: Seven Veterans Affairs Medical Centers. PARTICIPANTS: Veterans aged 70 or older without a prior diagnosis of cognitive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_58463340" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To assess the effect of screening on diagnosing cognitive impairment. DESIGN: Quality improvement initiative. SETTING: Seven Veterans Affairs Medical Centers. PARTICIPANTS: Veterans aged 70 or older without a prior diagnosis of cognitive impairment. MEASUREMENTS: Veterans failing a brief cognitive screen (Mini-Cog score <4/5) at a routine primary care visit were offered a further, comprehensive evaluation with an advance practice registered nurse trained in dementia care and integrated into the primary care clinic. Veterans completing the evaluation were reviewed in a consensus conference and assigned a diagnosis of dementia; cognitive impairment, no dementia; or no cognitive impairment. Total numbers of screens, associated scores (0-5), and the consensus diagnoses were tallied. New cognitive impairment diagnoses were also tracked for veterans who passed the screen but requested further evaluation, failed but declined further evaluation, or were not screened. Primary care provider satisfaction with the program also was assessed. RESULTS: Of 8,342 veterans offered screening, 8,063 (97%) accepted, 2,081 (26%) failed the screen, 580 (28%) agreed to further evaluation, and 540 (93%) were diagnosed with cognitive impairment, including 432 (75%) with dementia. For screen passes requesting further evaluation, 87% (103/118) had cognitive impairment, including 70% (82/118) with dementia. Screen failures declining further evaluation had 17% (259/1,501) incident cognitive impairment diagnosed through standard care, bringing the total newly documented cognitive impairment in all screens to 11% (902/8,063), versus 4% (1,242/28,349) in similar clinics without this program. Eighty-two percent of primary care providers in clinics with this program agreed that it provided a useful service. CONCLUSION: Screening combined with offering further evaluation increased new diagnoses of cognitive impairment in older veterans two to three times. Veterans accepted screening well, and providers found the program useful.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58463340" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b5e66834b47ae2cda01e447903d7af51" rel="nofollow" data-download="{"attachment_id":72862104,"asset_id":58463340,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72862104/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27777894" href="https://uw-us.academia.edu/SooBorson">Soo Borson</a><script data-card-contents-for-user="27777894" type="text/json">{"id":27777894,"first_name":"Soo","last_name":"Borson","domain_name":"uw-us","page_name":"SooBorson","display_name":"Soo Borson","profile_url":"https://uw-us.academia.edu/SooBorson?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_58463340 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58463340"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58463340, container: ".js-paper-rank-work_58463340", }); });</script></li><li class="js-percentile-work_58463340 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 58463340; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_58463340"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_58463340 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="58463340"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 58463340; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=58463340]").text(description); $(".js-view-count-work_58463340").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_58463340").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="58463340"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2974" rel="nofollow" href="https://www.academia.edu/Documents/in/Primary_Health_Care">Primary Health Care</a>, <script data-card-contents-for-ri="2974" type="text/json">{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3662" rel="nofollow" href="https://www.academia.edu/Documents/in/Dementia">Dementia</a>, <script data-card-contents-for-ri="3662" type="text/json">{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=58463340]'), work: {"id":58463340,"title":"Finding Dementia in Primary Care: The Results of a Clinical Demonstration Project","created_at":"2021-10-16T11:36:17.436-07:00","url":"https://www.academia.edu/58463340/Finding_Dementia_in_Primary_Care_The_Results_of_a_Clinical_Demonstration_Project?f_ri=43363","dom_id":"work_58463340","summary":"To assess the effect of screening on diagnosing cognitive impairment. DESIGN: Quality improvement initiative. SETTING: Seven Veterans Affairs Medical Centers. PARTICIPANTS: Veterans aged 70 or older without a prior diagnosis of cognitive impairment. MEASUREMENTS: Veterans failing a brief cognitive screen (Mini-Cog score \u003c4/5) at a routine primary care visit were offered a further, comprehensive evaluation with an advance practice registered nurse trained in dementia care and integrated into the primary care clinic. Veterans completing the evaluation were reviewed in a consensus conference and assigned a diagnosis of dementia; cognitive impairment, no dementia; or no cognitive impairment. Total numbers of screens, associated scores (0-5), and the consensus diagnoses were tallied. New cognitive impairment diagnoses were also tracked for veterans who passed the screen but requested further evaluation, failed but declined further evaluation, or were not screened. Primary care provider satisfaction with the program also was assessed. RESULTS: Of 8,342 veterans offered screening, 8,063 (97%) accepted, 2,081 (26%) failed the screen, 580 (28%) agreed to further evaluation, and 540 (93%) were diagnosed with cognitive impairment, including 432 (75%) with dementia. For screen passes requesting further evaluation, 87% (103/118) had cognitive impairment, including 70% (82/118) with dementia. Screen failures declining further evaluation had 17% (259/1,501) incident cognitive impairment diagnosed through standard care, bringing the total newly documented cognitive impairment in all screens to 11% (902/8,063), versus 4% (1,242/28,349) in similar clinics without this program. Eighty-two percent of primary care providers in clinics with this program agreed that it provided a useful service. CONCLUSION: Screening combined with offering further evaluation increased new diagnoses of cognitive impairment in older veterans two to three times. Veterans accepted screening well, and providers found the program useful.","downloadable_attachments":[{"id":72862104,"asset_id":58463340,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27777894,"first_name":"Soo","last_name":"Borson","domain_name":"uw-us","page_name":"SooBorson","display_name":"Soo Borson","profile_url":"https://uw-us.academia.edu/SooBorson?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2974,"name":"Primary Health Care","url":"https://www.academia.edu/Documents/in/Primary_Health_Care?f_ri=43363","nofollow":true},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=43363","nofollow":true},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":117019,"name":"Veterans","url":"https://www.academia.edu/Documents/in/Veterans?f_ri=43363"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects?f_ri=43363"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_32360937 coauthored" data-work_id="32360937" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/32360937/Nonomuraea_indica_sp_nov_novel_actinomycetes_isolated_from_lime_stone_open_pit_mine_India">Nonomuraea indica sp. nov., novel actinomycetes isolated from lime-stone open pit mine, India</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A Gram-positive, aerobic, nonmotile actinomycete strain designated DRQ-2 T was isolated from the soil sample collected from limestone open pit mine from the Gulbarga region, Karnataka province, India. Strain DRQ-2 T was identified as a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_32360937" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A Gram-positive, aerobic, nonmotile actinomycete strain designated DRQ-2 T was isolated from the soil sample collected from limestone open pit mine from the Gulbarga region, Karnataka province, India. Strain DRQ-2 T was identified as a member of the genus Nonomuraea by a polyphasic approach. Strain DRQ-2 T could be differentiated from other members of the genus Nonomuraea on the basis of physiology and 16S rRNA gene sequence analysis. The 16S rRNA gene sequence similarity of strain DRQ-2 T showed highest sequence similarity to Nonomuraea muscovyensis DSM 45913 T (99.1%), N. salmonea DSM 43678 T (98.2%) and N. maheshkhaliensis JCM 13929 T with 98.0%, respectively. Chemotaxonomic properties showing predominant menaquinones of MK-9 (H 4 ), MK-9(H 2 ) and MK-9(H 6 ), major polar lipids comprised diphosphatidylglycerol, phosphatidylmono methyl ethanolamine (PME), phosphatidylethanolamine (PE), hydroxy-PME (OH-PME), hydroxy PE (OH-PEE), phosphatidylglycerol (PG), ninhydrin-positive phosphoglycolipid and unknown phospholipid, fatty acids with major amounts of i-C 16:0 , ai-C 15:0 and ai-C 17:0 supported allocation of the strain to the genus Nonomuraea. Results of DNA-DNA hybridization and physiological tests allowed genotypic and phenotypic differentiation of strain DRQ-2 T from closely related species. The genomic DNA G+C content of the organism was 72.5 mol%. On the basis of phenotypic, chemotypic and molecular characteristics, strain DRQ-2 T represents a novel species of the genus Nonomuraea, for which the name N. indica sp. nov. is proposed, with type strain DRQ-2 T ( = NCIM 5480 T = CCTCC AA 209050 T ).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32360937" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4ae28b518ca42136ff62411af0322659" rel="nofollow" data-download="{"attachment_id":52566985,"asset_id":32360937,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52566985/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6786947" href="https://nbu-sa.academia.edu/RaziUddin">Razi Uddin</a><script data-card-contents-for-user="6786947" type="text/json">{"id":6786947,"first_name":"Razi","last_name":"Uddin","domain_name":"nbu-sa","page_name":"RaziUddin","display_name":"Razi Uddin","profile_url":"https://nbu-sa.academia.edu/RaziUddin?f_ri=43363","photo":"https://0.academia-photos.com/6786947/4252244/4946836/s65_razi.uddin.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-32360937">+2</span><div class="hidden js-additional-users-32360937"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/WenJunLi4">Wen-Jun Li</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/DayanandAgsar">Dayanand Agsar</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-32360937'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-32360937').html(); 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Strain DRQ-2 T was identified as a member of the genus Nonomuraea by a polyphasic approach. Strain DRQ-2 T could be differentiated from other members of the genus Nonomuraea on the basis of physiology and 16S rRNA gene sequence analysis. The 16S rRNA gene sequence similarity of strain DRQ-2 T showed highest sequence similarity to Nonomuraea muscovyensis DSM 45913 T (99.1%), N. salmonea DSM 43678 T (98.2%) and N. maheshkhaliensis JCM 13929 T with 98.0%, respectively. Chemotaxonomic properties showing predominant menaquinones of MK-9 (H 4 ), MK-9(H 2 ) and MK-9(H 6 ), major polar lipids comprised diphosphatidylglycerol, phosphatidylmono methyl ethanolamine (PME), phosphatidylethanolamine (PE), hydroxy-PME (OH-PME), hydroxy PE (OH-PEE), phosphatidylglycerol (PG), ninhydrin-positive phosphoglycolipid and unknown phospholipid, fatty acids with major amounts of i-C 16:0 , ai-C 15:0 and ai-C 17:0 supported allocation of the strain to the genus Nonomuraea. Results of DNA-DNA hybridization and physiological tests allowed genotypic and phenotypic differentiation of strain DRQ-2 T from closely related species. The genomic DNA G+C content of the organism was 72.5 mol%. On the basis of phenotypic, chemotypic and molecular characteristics, strain DRQ-2 T represents a novel species of the genus Nonomuraea, for which the name N. indica sp. nov. is proposed, with type strain DRQ-2 T ( = NCIM 5480 T = CCTCC AA 209050 T ).","downloadable_attachments":[{"id":52566985,"asset_id":32360937,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6786947,"first_name":"Razi","last_name":"Uddin","domain_name":"nbu-sa","page_name":"RaziUddin","display_name":"Razi Uddin","profile_url":"https://nbu-sa.academia.edu/RaziUddin?f_ri=43363","photo":"https://0.academia-photos.com/6786947/4252244/4946836/s65_razi.uddin.jpg"},{"id":53306874,"first_name":"Wen-Jun","last_name":"Li","domain_name":"independent","page_name":"WenJunLi4","display_name":"Wen-Jun Li","profile_url":"https://independent.academia.edu/WenJunLi4?f_ri=43363","photo":"/images/s65_no_pic.png"},{"id":62932509,"first_name":"Dayanand","last_name":"Agsar","domain_name":"independent","page_name":"DayanandAgsar","display_name":"Dayanand Agsar","profile_url":"https://independent.academia.edu/DayanandAgsar?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true},{"id":7076,"name":"Taxonomy","url":"https://www.academia.edu/Documents/in/Taxonomy?f_ri=43363","nofollow":true},{"id":8501,"name":"Phospholipids","url":"https://www.academia.edu/Documents/in/Phospholipids?f_ri=43363","nofollow":true},{"id":10655,"name":"Scanning Electron Microscopy","url":"https://www.academia.edu/Documents/in/Scanning_Electron_Microscopy?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":43838,"name":"India","url":"https://www.academia.edu/Documents/in/India?f_ri=43363"},{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny?f_ri=43363"},{"id":55168,"name":"Actinobacteria","url":"https://www.academia.edu/Documents/in/Actinobacteria?f_ri=43363"},{"id":72314,"name":"Fatty acids","url":"https://www.academia.edu/Documents/in/Fatty_acids?f_ri=43363"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance?f_ri=43363"},{"id":103360,"name":"Nucleic acid hybridization","url":"https://www.academia.edu/Documents/in/Nucleic_acid_hybridization?f_ri=43363"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry?f_ri=43363"},{"id":131237,"name":"Cluster Analysis","url":"https://www.academia.edu/Documents/in/Cluster_Analysis?f_ri=43363"},{"id":231547,"name":"Soil Microbiology","url":"https://www.academia.edu/Documents/in/Soil_Microbiology?f_ri=43363"},{"id":479207,"name":"Glycolipids","url":"https://www.academia.edu/Documents/in/Glycolipids?f_ri=43363"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=43363"},{"id":2562545,"name":"Glycopeptides","url":"https://www.academia.edu/Documents/in/Glycopeptides?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27365970" data-work_id="27365970" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27365970/Attitudes_of_new_mothers_towards_genetics_and_newborn_screening">Attitudes of new mothers towards genetics and newborn screening</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Objective. To evaluate new mothers' opinions of genetics and newborn screening.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27365970" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9590e83178c5730ff4e0b8bcc1c1afe5" rel="nofollow" data-download="{"attachment_id":47621300,"asset_id":27365970,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47621300/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51484336" href="https://nd-au.academia.edu/JulieQuinlivan">Julie Quinlivan</a><script data-card-contents-for-user="51484336" type="text/json">{"id":51484336,"first_name":"Julie","last_name":"Quinlivan","domain_name":"nd-au","page_name":"JulieQuinlivan","display_name":"Julie Quinlivan","profile_url":"https://nd-au.academia.edu/JulieQuinlivan?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27365970 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27365970"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27365970, container: ".js-paper-rank-work_27365970", }); 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$(".js-view-count[data-work-id=27365970]").text(description); $(".js-view-count-work_27365970").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27365970").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27365970"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="310" rel="nofollow" href="https://www.academia.edu/Documents/in/Demography">Demography</a>, <script data-card-contents-for-ri="310" type="text/json">{"id":310,"name":"Demography","url":"https://www.academia.edu/Documents/in/Demography?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="814" rel="nofollow" href="https://www.academia.edu/Documents/in/Ethics">Ethics</a>, <script data-card-contents-for-ri="814" type="text/json">{"id":814,"name":"Ethics","url":"https://www.academia.edu/Documents/in/Ethics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8562" rel="nofollow" href="https://www.academia.edu/Documents/in/Informed_Consent">Informed Consent</a><script data-card-contents-for-ri="8562" type="text/json">{"id":8562,"name":"Informed Consent","url":"https://www.academia.edu/Documents/in/Informed_Consent?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27365970]'), work: {"id":27365970,"title":"Attitudes of new mothers towards genetics and newborn screening","created_at":"2016-07-29T06:50:35.224-07:00","url":"https://www.academia.edu/27365970/Attitudes_of_new_mothers_towards_genetics_and_newborn_screening?f_ri=43363","dom_id":"work_27365970","summary":"Objective. To evaluate new mothers' opinions of genetics and newborn screening.","downloadable_attachments":[{"id":47621300,"asset_id":27365970,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51484336,"first_name":"Julie","last_name":"Quinlivan","domain_name":"nd-au","page_name":"JulieQuinlivan","display_name":"Julie Quinlivan","profile_url":"https://nd-au.academia.edu/JulieQuinlivan?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":310,"name":"Demography","url":"https://www.academia.edu/Documents/in/Demography?f_ri=43363","nofollow":true},{"id":814,"name":"Ethics","url":"https://www.academia.edu/Documents/in/Ethics?f_ri=43363","nofollow":true},{"id":8562,"name":"Informed Consent","url":"https://www.academia.edu/Documents/in/Informed_Consent?f_ri=43363","nofollow":true},{"id":24837,"name":"Peer Review","url":"https://www.academia.edu/Documents/in/Peer_Review?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":73153,"name":"Genetic Testing","url":"https://www.academia.edu/Documents/in/Genetic_Testing?f_ri=43363"},{"id":103298,"name":"Blood sampling","url":"https://www.academia.edu/Documents/in/Blood_sampling?f_ri=43363"},{"id":127605,"name":"Health Science","url":"https://www.academia.edu/Documents/in/Health_Science?f_ri=43363"},{"id":155199,"name":"Genetic Screening","url":"https://www.academia.edu/Documents/in/Genetic_Screening?f_ri=43363"},{"id":162282,"name":"Mothers","url":"https://www.academia.edu/Documents/in/Mothers?f_ri=43363"},{"id":197938,"name":"Newborn Screening","url":"https://www.academia.edu/Documents/in/Newborn_Screening?f_ri=43363"},{"id":219477,"name":"Family Planning","url":"https://www.academia.edu/Documents/in/Family_Planning?f_ri=43363"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=43363"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=43363"},{"id":535184,"name":"Maternal Behavior","url":"https://www.academia.edu/Documents/in/Maternal_Behavior?f_ri=43363"},{"id":644507,"name":"Antenatal Care","url":"https://www.academia.edu/Documents/in/Antenatal_Care?f_ri=43363"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects?f_ri=43363"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11475286" data-work_id="11475286" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11475286/Mouth_self_examination_to_improve_oral_cancer_awareness_and_early_detection_in_a_high_risk_population">Mouth self-examination to improve oral cancer awareness and early detection in a high-risk population</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11475286" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reduction in the incidence of oral cancer. The objective of this study was to evaluate the effectiveness of mouth self-examination (MSE) in improving the awareness of oral cancer and its risk factors as well as test its feasibility as an oral cancer-screening tool. The study was carried out in a high-risk population of 57,704 from India, of which, 34,766 individuals who have met the eligibility criteria formed the study population. MSE brochures and trained health workers were employed for the purpose of health education and cancer screening. The present study compared their efficacy to detect oral lesions. Subjects with suspicious lesions were referred to the trained oral cancer specialist for confirmation. A questionnaire to assess the awareness of oral cancer and its risk factors was developed and validated. SPSS (v.11.0) was used for data analysis. The program identified 216 cases of potentially malignant lesions as well as three cases of oral cancer. The findings of MSE and health workers showed 72% concordance, while that of health workers and oral cancer specialist showed 100% concordance. MSE had a low sensitivity of 18%, while the specificity was 99.9%. Though the technique identified high-risk lesions such as red patches (66.7%) and non-healing ulcers (42.9%), the detection rate of white patches was low (12.7%). Overall awareness of oral cancer and its risk factors after introduction of MSE program was over 80%; but the compliance to seek treatment was poor (32%). Mouth self-examination may be used as an effective tool to improve the awareness of oral cancer and for the early detection of lesions.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11475286" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bf930e2cac5b39bcd391c05f53cd277d" rel="nofollow" data-download="{"attachment_id":46686410,"asset_id":11475286,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46686410/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="27949098" href="https://msctr.academia.edu/AmrithaSuresh">Amritha Suresh</a><script data-card-contents-for-user="27949098" type="text/json">{"id":27949098,"first_name":"Amritha","last_name":"Suresh","domain_name":"msctr","page_name":"AmrithaSuresh","display_name":"Amritha Suresh","profile_url":"https://msctr.academia.edu/AmrithaSuresh?f_ri=43363","photo":"https://0.academia-photos.com/27949098/146234034/135773985/s65_amritha.suresh.png"}</script></span></span></li><li class="js-paper-rank-work_11475286 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11475286"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11475286, container: ".js-paper-rank-work_11475286", }); 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$(".js-view-count[data-work-id=11475286]").text(description); $(".js-view-count-work_11475286").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11475286").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11475286"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">27</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="596" rel="nofollow" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="981" rel="nofollow" href="https://www.academia.edu/Documents/in/Health_Promotion">Health Promotion</a>, <script data-card-contents-for-ri="981" type="text/json">{"id":981,"name":"Health Promotion","url":"https://www.academia.edu/Documents/in/Health_Promotion?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11475286]'), work: {"id":11475286,"title":"Mouth self-examination to improve oral cancer awareness and early detection in a high-risk population","created_at":"2015-03-16T22:57:28.394-07:00","url":"https://www.academia.edu/11475286/Mouth_self_examination_to_improve_oral_cancer_awareness_and_early_detection_in_a_high_risk_population?f_ri=43363","dom_id":"work_11475286","summary":"Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reduction in the incidence of oral cancer. The objective of this study was to evaluate the effectiveness of mouth self-examination (MSE) in improving the awareness of oral cancer and its risk factors as well as test its feasibility as an oral cancer-screening tool. The study was carried out in a high-risk population of 57,704 from India, of which, 34,766 individuals who have met the eligibility criteria formed the study population. MSE brochures and trained health workers were employed for the purpose of health education and cancer screening. The present study compared their efficacy to detect oral lesions. Subjects with suspicious lesions were referred to the trained oral cancer specialist for confirmation. A questionnaire to assess the awareness of oral cancer and its risk factors was developed and validated. SPSS (v.11.0) was used for data analysis. The program identified 216 cases of potentially malignant lesions as well as three cases of oral cancer. The findings of MSE and health workers showed 72% concordance, while that of health workers and oral cancer specialist showed 100% concordance. MSE had a low sensitivity of 18%, while the specificity was 99.9%. Though the technique identified high-risk lesions such as red patches (66.7%) and non-healing ulcers (42.9%), the detection rate of white patches was low (12.7%). Overall awareness of oral cancer and its risk factors after introduction of MSE program was over 80%; but the compliance to seek treatment was poor (32%). Mouth self-examination may be used as an effective tool to improve the awareness of oral cancer and for the early detection of lesions.","downloadable_attachments":[{"id":46686410,"asset_id":11475286,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27949098,"first_name":"Amritha","last_name":"Suresh","domain_name":"msctr","page_name":"AmrithaSuresh","display_name":"Amritha Suresh","profile_url":"https://msctr.academia.edu/AmrithaSuresh?f_ri=43363","photo":"https://0.academia-photos.com/27949098/146234034/135773985/s65_amritha.suresh.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=43363","nofollow":true},{"id":981,"name":"Health Promotion","url":"https://www.academia.edu/Documents/in/Health_Promotion?f_ri=43363","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":43838,"name":"India","url":"https://www.academia.edu/Documents/in/India?f_ri=43363"},{"id":44096,"name":"Knowledge","url":"https://www.academia.edu/Documents/in/Knowledge?f_ri=43363"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=43363"},{"id":69841,"name":"Standard Deviation","url":"https://www.academia.edu/Documents/in/Standard_Deviation?f_ri=43363"},{"id":100540,"name":"Feasibility Studies","url":"https://www.academia.edu/Documents/in/Feasibility_Studies?f_ri=43363"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals?f_ri=43363"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=43363"},{"id":139968,"name":"Oral Oncology","url":"https://www.academia.edu/Documents/in/Oral_Oncology?f_ri=43363"},{"id":179681,"name":"Oral Cancer","url":"https://www.academia.edu/Documents/in/Oral_Cancer?f_ri=43363"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=43363"},{"id":197351,"name":"Awareness","url":"https://www.academia.edu/Documents/in/Awareness?f_ri=43363"},{"id":260543,"name":"MSE","url":"https://www.academia.edu/Documents/in/MSE?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=43363"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=43363"},{"id":371528,"name":"Early Detection","url":"https://www.academia.edu/Documents/in/Early_Detection?f_ri=43363"},{"id":375141,"name":"Mouth Neoplasms","url":"https://www.academia.edu/Documents/in/Mouth_Neoplasms?f_ri=43363"},{"id":375142,"name":"Precancerous Conditions","url":"https://www.academia.edu/Documents/in/Precancerous_Conditions?f_ri=43363"},{"id":375293,"name":"Mouth Diseases","url":"https://www.academia.edu/Documents/in/Mouth_Diseases?f_ri=43363"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=43363"},{"id":517438,"name":"Breast Self Examination","url":"https://www.academia.edu/Documents/in/Breast_Self_Examination?f_ri=43363"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=43363"},{"id":926113,"name":"Pamphlets","url":"https://www.academia.edu/Documents/in/Pamphlets?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15392242" data-work_id="15392242" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15392242/Biopriming_of_Infected_Carrot_Seed_with_an_Antagonist_Clonostachys_rosea_Selected_for_Control_of_Seedborne_Alternaria_spp">Biopriming of Infected Carrot Seed with an Antagonist, Clonostachys rosea , Selected for Control of Seedborne Alternaria spp</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Jensen, B., Knudsen, I. M. B., Madsen, M., and Jensen, D. F. 2004. Biopriming of infected carrot seed with an antagonist, Clonostachys rosea, selected for control of seedborne Alternaria spp. Phytopathology 94:551-560.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15392242" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e2ab4287d0233dfffb33a376f6c932d4" rel="nofollow" data-download="{"attachment_id":41555959,"asset_id":15392242,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41555959/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34538663" href="https://independent.academia.edu/DanJensen4">Dan Jensen</a><script data-card-contents-for-user="34538663" type="text/json">{"id":34538663,"first_name":"Dan","last_name":"Jensen","domain_name":"independent","page_name":"DanJensen4","display_name":"Dan Jensen","profile_url":"https://independent.academia.edu/DanJensen4?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15392242 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15392242"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15392242, container: ".js-paper-rank-work_15392242", }); });</script></li><li class="js-percentile-work_15392242 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15392242; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_15392242"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_15392242 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="15392242"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15392242; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15392242]").text(description); $(".js-view-count-work_15392242").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15392242").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15392242"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="159" rel="nofollow" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a>, <script data-card-contents-for-ri="159" type="text/json">{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2512" rel="nofollow" href="https://www.academia.edu/Documents/in/Phytopathology">Phytopathology</a>, <script data-card-contents-for-ri="2512" type="text/json">{"id":2512,"name":"Phytopathology","url":"https://www.academia.edu/Documents/in/Phytopathology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="5541" rel="nofollow" href="https://www.academia.edu/Documents/in/Plant_Biology">Plant Biology</a>, <script data-card-contents-for-ri="5541" type="text/json">{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22220" rel="nofollow" href="https://www.academia.edu/Documents/in/Priming">Priming</a><script data-card-contents-for-ri="22220" type="text/json">{"id":22220,"name":"Priming","url":"https://www.academia.edu/Documents/in/Priming?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15392242]'), work: {"id":15392242,"title":"Biopriming of Infected Carrot Seed with an Antagonist, Clonostachys rosea , Selected for Control of Seedborne Alternaria spp","created_at":"2015-09-04T06:54:14.032-07:00","url":"https://www.academia.edu/15392242/Biopriming_of_Infected_Carrot_Seed_with_an_Antagonist_Clonostachys_rosea_Selected_for_Control_of_Seedborne_Alternaria_spp?f_ri=43363","dom_id":"work_15392242","summary":"Jensen, B., Knudsen, I. M. B., Madsen, M., and Jensen, D. F. 2004. Biopriming of infected carrot seed with an antagonist, Clonostachys rosea, selected for control of seedborne Alternaria spp. Phytopathology 94:551-560.","downloadable_attachments":[{"id":41555959,"asset_id":15392242,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34538663,"first_name":"Dan","last_name":"Jensen","domain_name":"independent","page_name":"DanJensen4","display_name":"Dan Jensen","profile_url":"https://independent.academia.edu/DanJensen4?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true},{"id":2512,"name":"Phytopathology","url":"https://www.academia.edu/Documents/in/Phytopathology?f_ri=43363","nofollow":true},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=43363","nofollow":true},{"id":22220,"name":"Priming","url":"https://www.academia.edu/Documents/in/Priming?f_ri=43363","nofollow":true},{"id":23515,"name":"Biological Control","url":"https://www.academia.edu/Documents/in/Biological_Control?f_ri=43363"},{"id":41749,"name":"Genetic Engineering","url":"https://www.academia.edu/Documents/in/Genetic_Engineering?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":66973,"name":"Plant diseases","url":"https://www.academia.edu/Documents/in/Plant_diseases?f_ri=43363"},{"id":143509,"name":"Genetic transformation","url":"https://www.academia.edu/Documents/in/Genetic_transformation?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_3753627" data-work_id="3753627" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/3753627/Screening_for_thrombophilia_and_antithrombotic_prophylaxis_in_pregnancy_Guidelines_of_the_Italian_Society_for_Haemostasis_and_Thrombosis_SISET">Screening for thrombophilia and antithrombotic prophylaxis in pregnancy: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The term thrombophilia describes an increased tendency to develop thrombosis and many laboratory markers with different strengths of association with thrombosis have been identified. The main causes of maternal mortality and morbidity in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_3753627" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The term thrombophilia describes an increased tendency to develop thrombosis and many laboratory markers with different strengths of association with thrombosis have been identified. The main causes of maternal mortality and morbidity in developed countries is venous thromboembolism (VTE) and obstetric complications. During pregnancy and puerperium the risk for VTE increases due to hemostatic imbalance towards a prothrombotic state, and it is further increased in women carriers of thrombophilia; recent studies have also demonstrated an association between thrombophilia and obstetric complications. These complications are, therefore, considered potentially preventable with the prophylactic administration of anticoagulant drugs, although their efficacy is not proven by data from randomized controlled trials. After a systematic comprehensive literature review and using a rigorous methodology, the expert panel formulated recommendations regarding the usefulness of screening for thrombophilia in pregnancy to identify high-risk women and for the management of antithrombotic prophyalxis. When evidence is lacking, consensus-based recommendations are provided.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3753627" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2e342e39728b88b7b8401e1b12d174dd" rel="nofollow" data-download="{"attachment_id":50146421,"asset_id":3753627,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50146421/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4607569" href="https://independent.academia.edu/ielvira">ida elvira</a><script data-card-contents-for-user="4607569" type="text/json">{"id":4607569,"first_name":"ida","last_name":"elvira","domain_name":"independent","page_name":"ielvira","display_name":"ida elvira","profile_url":"https://independent.academia.edu/ielvira?f_ri=43363","photo":"https://0.academia-photos.com/4607569/19769860/19612510/s65_ida.elvira.jpg"}</script></span></span></li><li class="js-paper-rank-work_3753627 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="3753627"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 3753627, container: ".js-paper-rank-work_3753627", }); 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$(".js-view-count[data-work-id=3753627]").text(description); $(".js-view-count-work_3753627").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_3753627").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="3753627"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="8207" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk">Risk</a>, <script data-card-contents-for-ri="8207" type="text/json">{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16288" rel="nofollow" href="https://www.academia.edu/Documents/in/Public_Health">Public Health</a>, <script data-card-contents-for-ri="16288" type="text/json">{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44293" rel="nofollow" href="https://www.academia.edu/Documents/in/Literature_Review">Literature Review</a><script data-card-contents-for-ri="44293" type="text/json">{"id":44293,"name":"Literature Review","url":"https://www.academia.edu/Documents/in/Literature_Review?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3753627]'), work: {"id":3753627,"title":"Screening for thrombophilia and antithrombotic prophylaxis in pregnancy: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET","created_at":"2013-06-20T15:13:10.966-07:00","url":"https://www.academia.edu/3753627/Screening_for_thrombophilia_and_antithrombotic_prophylaxis_in_pregnancy_Guidelines_of_the_Italian_Society_for_Haemostasis_and_Thrombosis_SISET?f_ri=43363","dom_id":"work_3753627","summary":"The term thrombophilia describes an increased tendency to develop thrombosis and many laboratory markers with different strengths of association with thrombosis have been identified. The main causes of maternal mortality and morbidity in developed countries is venous thromboembolism (VTE) and obstetric complications. During pregnancy and puerperium the risk for VTE increases due to hemostatic imbalance towards a prothrombotic state, and it is further increased in women carriers of thrombophilia; recent studies have also demonstrated an association between thrombophilia and obstetric complications. These complications are, therefore, considered potentially preventable with the prophylactic administration of anticoagulant drugs, although their efficacy is not proven by data from randomized controlled trials. After a systematic comprehensive literature review and using a rigorous methodology, the expert panel formulated recommendations regarding the usefulness of screening for thrombophilia in pregnancy to identify high-risk women and for the management of antithrombotic prophyalxis. When evidence is lacking, consensus-based recommendations are provided.","downloadable_attachments":[{"id":50146421,"asset_id":3753627,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4607569,"first_name":"ida","last_name":"elvira","domain_name":"independent","page_name":"ielvira","display_name":"ida elvira","profile_url":"https://independent.academia.edu/ielvira?f_ri=43363","photo":"https://0.academia-photos.com/4607569/19769860/19612510/s65_ida.elvira.jpg"}],"research_interests":[{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=43363","nofollow":true},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":44293,"name":"Literature Review","url":"https://www.academia.edu/Documents/in/Literature_Review?f_ri=43363","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=43363"},{"id":52043,"name":"Maternal Mortality","url":"https://www.academia.edu/Documents/in/Maternal_Mortality?f_ri=43363"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=43363"},{"id":70854,"name":"Developing Country","url":"https://www.academia.edu/Documents/in/Developing_Country?f_ri=43363"},{"id":189949,"name":"Anticoagulants","url":"https://www.academia.edu/Documents/in/Anticoagulants?f_ri=43363"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=43363"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=43363"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial?f_ri=43363"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis?f_ri=43363"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=43363"},{"id":653601,"name":"Venous thromboembolism","url":"https://www.academia.edu/Documents/in/Venous_thromboembolism?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78128239" data-work_id="78128239" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78128239/Identification_of_novel_rapamycin_derivatives_as_low_level_impurities_in_active_pharmaceutical_ingredients">Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We describe the identification of novel rapamycin derivatives present as low-level impurities in active pharmaceutical ingredients using an integrated, multidisciplinary approach. Rapamycin, a fermentation-derived natural product is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78128239" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We describe the identification of novel rapamycin derivatives present as low-level impurities in active pharmaceutical ingredients using an integrated, multidisciplinary approach. Rapamycin, a fermentation-derived natural product is itself used clinically and provides the starting material for several rapamycin analog drugs, typically used in oncology. LC-MS proved a sensitive means to analyze impurity profiles in batches of rapamycin. MS fragmentation was used to gain structural insight into these impurities, usually fermentation by-products, structurally very similar to rapamycin. In cases where MS fragmentation was unable to provide unambiguous structural identification, the impurities were isolated and purified using orthogonal HPLC methods. Using the higher mass sensitivity of small-volume NMR microprobes, submilligram amounts of isolated impurities were sufficient for further characterization by multidimensional NMR spectroscopy. Full assignment of the 1 H and 13 C NMR signals revealed the structure of these impurities at an atomic level. This systematic workflow enabled the identification of several novel rapamycin congeners from active pharmaceutical ingredient without the need for large-scale isolation of impurities. For illustration, two novel rapamycin derivatives are described in this study: 12-ethyl-rapamycin and 33-ethyl-rapamycin, which exemplify previously unreported modifications on the carbon skeleton of the rapamycin macrocycle. The methodologies described here can be of wide use for identification of closely related structures found; for example as fermentation by-products, metabolites or degradants of natural product-based drugs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78128239" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bc1c5247900cace02e95e0536d2d0ddf" rel="nofollow" data-download="{"attachment_id":85284208,"asset_id":78128239,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85284208/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="222377555" href="https://independent.academia.edu/NarayanaNarasimhan">Narayana Narasimhan</a><script data-card-contents-for-user="222377555" type="text/json">{"id":222377555,"first_name":"Narayana","last_name":"Narasimhan","domain_name":"independent","page_name":"NarayanaNarasimhan","display_name":"Narayana Narasimhan","profile_url":"https://independent.academia.edu/NarayanaNarasimhan?f_ri=43363","photo":"https://0.academia-photos.com/222377555/80000124/68573303/s65_narayana.narasimhan.png"}</script></span></span></li><li class="js-paper-rank-work_78128239 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78128239"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78128239, container: ".js-paper-rank-work_78128239", }); 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$(".js-view-count[data-work-id=78128239]").text(description); $(".js-view-count-work_78128239").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78128239").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78128239"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="159" rel="nofollow" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a>, <script data-card-contents-for-ri="159" type="text/json">{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="5769" rel="nofollow" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7076" rel="nofollow" href="https://www.academia.edu/Documents/in/Taxonomy">Taxonomy</a><script data-card-contents-for-ri="7076" type="text/json">{"id":7076,"name":"Taxonomy","url":"https://www.academia.edu/Documents/in/Taxonomy?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78128239]'), work: {"id":78128239,"title":"Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients","created_at":"2022-05-01T08:13:36.172-07:00","url":"https://www.academia.edu/78128239/Identification_of_novel_rapamycin_derivatives_as_low_level_impurities_in_active_pharmaceutical_ingredients?f_ri=43363","dom_id":"work_78128239","summary":"We describe the identification of novel rapamycin derivatives present as low-level impurities in active pharmaceutical ingredients using an integrated, multidisciplinary approach. Rapamycin, a fermentation-derived natural product is itself used clinically and provides the starting material for several rapamycin analog drugs, typically used in oncology. LC-MS proved a sensitive means to analyze impurity profiles in batches of rapamycin. MS fragmentation was used to gain structural insight into these impurities, usually fermentation by-products, structurally very similar to rapamycin. In cases where MS fragmentation was unable to provide unambiguous structural identification, the impurities were isolated and purified using orthogonal HPLC methods. Using the higher mass sensitivity of small-volume NMR microprobes, submilligram amounts of isolated impurities were sufficient for further characterization by multidimensional NMR spectroscopy. Full assignment of the 1 H and 13 C NMR signals revealed the structure of these impurities at an atomic level. This systematic workflow enabled the identification of several novel rapamycin congeners from active pharmaceutical ingredient without the need for large-scale isolation of impurities. For illustration, two novel rapamycin derivatives are described in this study: 12-ethyl-rapamycin and 33-ethyl-rapamycin, which exemplify previously unreported modifications on the carbon skeleton of the rapamycin macrocycle. The methodologies described here can be of wide use for identification of closely related structures found; for example as fermentation by-products, metabolites or degradants of natural product-based drugs.","downloadable_attachments":[{"id":85284208,"asset_id":78128239,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":222377555,"first_name":"Narayana","last_name":"Narasimhan","domain_name":"independent","page_name":"NarayanaNarasimhan","display_name":"Narayana Narasimhan","profile_url":"https://independent.academia.edu/NarayanaNarasimhan?f_ri=43363","photo":"https://0.academia-photos.com/222377555/80000124/68573303/s65_narayana.narasimhan.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=43363","nofollow":true},{"id":7076,"name":"Taxonomy","url":"https://www.academia.edu/Documents/in/Taxonomy?f_ri=43363","nofollow":true},{"id":12134,"name":"NMR Spectroscopy","url":"https://www.academia.edu/Documents/in/NMR_Spectroscopy?f_ri=43363"},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance?f_ri=43363"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry?f_ri=43363"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry?f_ri=43363"},{"id":225787,"name":"High Performance Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Performance_Liquid_Chromatography?f_ri=43363"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography?f_ri=43363"},{"id":758278,"name":"Large Scale","url":"https://www.academia.edu/Documents/in/Large_Scale?f_ri=43363"},{"id":816534,"name":"Multidisciplinary Approach","url":"https://www.academia.edu/Documents/in/Multidisciplinary_Approach?f_ri=43363"},{"id":1126207,"name":"Active Pharmaceutical Ingredient","url":"https://www.academia.edu/Documents/in/Active_Pharmaceutical_Ingredient?f_ri=43363"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus?f_ri=43363"},{"id":1765959,"name":"Pharmaceutical Formulation","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Formulation?f_ri=43363"},{"id":2380004,"name":"Pharmaceutical preparations","url":"https://www.academia.edu/Documents/in/Pharmaceutical_preparations?f_ri=43363"},{"id":2562545,"name":"Glycopeptides","url":"https://www.academia.edu/Documents/in/Glycopeptides?f_ri=43363"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_71196876" data-work_id="71196876" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/71196876/Development_and_evaluation_of_a_comprehensive_screening_for_orofacial_dysfunction">Development and evaluation of a comprehensive screening for orofacial dysfunction</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim was to develop a comprehensive screening instrument for evaluation of orofacial dysfunction that was easy to perform for different health professionals without special equipment. The Nordic Orofacial Test--Screening (NOT-S),... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_71196876" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim was to develop a comprehensive screening instrument for evaluation of orofacial dysfunction that was easy to perform for different health professionals without special equipment. The Nordic Orofacial Test--Screening (NOT-S), consisting of a structured interview and clinical examination,was developed with a picture manual illustrating the different tasks in the examination. It was first tested in a Swedish version, and later translated to other Nordic languages, and to English. The interview reflected six domains, (I) Sensory function, (II) Breathing, (III) Habits, (IV) Chewing and swallowing, (V) Drooling, and (VI) Dryness of the mouth, and the examination included six domains representing (1) The face at rest, and tasks regarding (2) Nose breathing, (3) Facial expression, (4) Masticatory muscle and jaw function, (5) Oral motor function, and (6) Speech. One or more &quot;yes&quot; for impairment in a domain resulted in one point (maximum NOT-S score 12 points). The mean NOT-...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/71196876" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="077b47e42faf47f10cd9bd15ffd869a3" rel="nofollow" data-download="{"attachment_id":80647641,"asset_id":71196876,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80647641/download_file?st=MTc0MDM0Mjc3Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43234194" href="https://ku-dk.academia.edu/MereteBakke">Merete Bakke</a><script data-card-contents-for-user="43234194" type="text/json">{"id":43234194,"first_name":"Merete","last_name":"Bakke","domain_name":"ku-dk","page_name":"MereteBakke","display_name":"Merete Bakke","profile_url":"https://ku-dk.academia.edu/MereteBakke?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_71196876 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="71196876"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 71196876, container: ".js-paper-rank-work_71196876", }); 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The Nordic Orofacial Test--Screening (NOT-S), consisting of a structured interview and clinical examination,was developed with a picture manual illustrating the different tasks in the examination. It was first tested in a Swedish version, and later translated to other Nordic languages, and to English. The interview reflected six domains, (I) Sensory function, (II) Breathing, (III) Habits, (IV) Chewing and swallowing, (V) Drooling, and (VI) Dryness of the mouth, and the examination included six domains representing (1) The face at rest, and tasks regarding (2) Nose breathing, (3) Facial expression, (4) Masticatory muscle and jaw function, (5) Oral motor function, and (6) Speech. One or more \u0026quot;yes\u0026quot; for impairment in a domain resulted in one point (maximum NOT-S score 12 points). The mean NOT-...","downloadable_attachments":[{"id":80647641,"asset_id":71196876,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43234194,"first_name":"Merete","last_name":"Bakke","domain_name":"ku-dk","page_name":"MereteBakke","display_name":"Merete Bakke","profile_url":"https://ku-dk.academia.edu/MereteBakke?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=43363","nofollow":true},{"id":8910,"name":"Evaluation","url":"https://www.academia.edu/Documents/in/Evaluation?f_ri=43363","nofollow":true},{"id":11636,"name":"Face","url":"https://www.academia.edu/Documents/in/Face?f_ri=43363","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=43363"},{"id":111842,"name":"Otorhinolaryngology","url":"https://www.academia.edu/Documents/in/Otorhinolaryngology?f_ri=43363"},{"id":183881,"name":"Chewing","url":"https://www.academia.edu/Documents/in/Chewing?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":415832,"name":"Mastication","url":"https://www.academia.edu/Documents/in/Mastication?f_ri=43363"},{"id":799412,"name":"Chromosome Disorders","url":"https://www.academia.edu/Documents/in/Chromosome_Disorders?f_ri=43363"},{"id":1161416,"name":"Congenital abnormalities","url":"https://www.academia.edu/Documents/in/Congenital_abnormalities?f_ri=43363"},{"id":1423078,"name":"Nervous System Diseases","url":"https://www.academia.edu/Documents/in/Nervous_System_Diseases?f_ri=43363"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=43363"},{"id":3196731,"name":"Interviews as topic","url":"https://www.academia.edu/Documents/in/Interviews_as_topic?f_ri=43363"},{"id":3275398,"name":"Deglutition","url":"https://www.academia.edu/Documents/in/Deglutition?f_ri=43363"},{"id":3693190,"name":"mass Screening","url":"https://www.academia.edu/Documents/in/mass_Screening?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_68346680 coauthored" data-work_id="68346680" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68346680/Utilizaci%C3%B3n_de_un_dispositivo_m%C3%B3vil_de_tecnolog%C3%ADa_electr%C3%B3nica_para_tamizaje_de_fibrilaci%C3%B3n_auricular_Estudio_piloto">Utilización de un dispositivo móvil de tecnología electrónica para tamizaje de fibrilación auricular. Estudio piloto</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">La fibrilación auricular (FA) es un problema de salud pública que genera mortalidad y morbilidad, con su mayor impacto en mayores de 65 años. Su detección es especialmente relevante para la población de riesgo. Este estudio piloto propone... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_68346680" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">La fibrilación auricular (FA) es un problema de salud pública que genera mortalidad y morbilidad, con su mayor impacto en mayores de 65 años. Su detección es especialmente relevante para la población de riesgo. Este estudio piloto propone valorar la utilidad de un dispositivo móvil de tecnología electrónica (DMTE) para el tamizaje de FA. Objetivo primario: evaluar la validez y confiabilidad de un DMTE para identificar FA. Objetivo secundario: validar los procesos de recolección, transmisión, almacenamiento, procesamiento e interpretación de los datos obtenidos. Método: los asistentes a 5 talleres del Plan Ibirapitá (entre el 15 de octubre y el 30 de noviembre de 2018) fueron invitados a participar del estudio. Se utilizó un DMTE (sensor KardiaMobile de AliveCor®) cuyo registro se contrastó con el trazado del ECG de 12 derivaciones realizado en forma casi simultánea. Se compararon los diagnósticos automáticos con los realizados por dos cardiólogos expertos de forma independiente, a partir de la lectura del registro realizado con el DMTE y de un ECG de 12 derivaciones. Resultados: participaron del estudio 114 beneficiarios del Plan Ibirapitá, 78 del sexo femenino. La edad fue de 72,5 ± 5,36 años (rango: 53-87 años). La sensibilidad para el diagnóstico de FA del DMTE fue de 100%, con una especificidad de 96,6%. (VPP = 57,1% VPN = 100%) y una proporción de diagnóstico correcto de 96,8%. El DMTE catalogó como "sin clasificar" al 18,4% de los trazados. Considerando esto, la proporción de diagnóstico correcto disminuyó a 78,9%, sin presentar falsos negativos. Conclusiones: el cribado de FA con la utilización de un DMTE en una población de adultos mayores es factible y confiable. El hallazgo de un 18,4% de trazados con diagnóstico automático "sin clasificar" hace necesario contar con recursos humanos calificados para realizar la confirmación diagnóstica en esos registros.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/68346680" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="36bbb329bbfedbf69259fbe3cf9601e7" rel="nofollow" data-download="{"attachment_id":78852610,"asset_id":68346680,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78852610/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="63647831" href="https://udelar.academia.edu/Ram%C3%B3n%C3%81lvarezVaz">Ramón Álvarez-Vaz</a><script data-card-contents-for-user="63647831" type="text/json">{"id":63647831,"first_name":"Ramón","last_name":"Álvarez-Vaz","domain_name":"udelar","page_name":"RamónÁlvarezVaz","display_name":"Ramón Álvarez-Vaz","profile_url":"https://udelar.academia.edu/Ram%C3%B3n%C3%81lvarezVaz?f_ri=43363","photo":"https://0.academia-photos.com/63647831/16523043/16857980/s65_ram_n.alvarez_vaz.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-68346680">+1</span><div class="hidden js-additional-users-68346680"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/VirginiaEstrag%C3%B3">Virginia Estragó</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-68346680'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-68346680').html(); 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Estudio piloto","created_at":"2022-01-15T16:00:42.886-08:00","url":"https://www.academia.edu/68346680/Utilizaci%C3%B3n_de_un_dispositivo_m%C3%B3vil_de_tecnolog%C3%ADa_electr%C3%B3nica_para_tamizaje_de_fibrilaci%C3%B3n_auricular_Estudio_piloto?f_ri=43363","dom_id":"work_68346680","summary":"La fibrilación auricular (FA) es un problema de salud pública que genera mortalidad y morbilidad, con su mayor impacto en mayores de 65 años. Su detección es especialmente relevante para la población de riesgo. Este estudio piloto propone valorar la utilidad de un dispositivo móvil de tecnología electrónica (DMTE) para el tamizaje de FA. Objetivo primario: evaluar la validez y confiabilidad de un DMTE para identificar FA. Objetivo secundario: validar los procesos de recolección, transmisión, almacenamiento, procesamiento e interpretación de los datos obtenidos. Método: los asistentes a 5 talleres del Plan Ibirapitá (entre el 15 de octubre y el 30 de noviembre de 2018) fueron invitados a participar del estudio. Se utilizó un DMTE (sensor KardiaMobile de AliveCor®) cuyo registro se contrastó con el trazado del ECG de 12 derivaciones realizado en forma casi simultánea. Se compararon los diagnósticos automáticos con los realizados por dos cardiólogos expertos de forma independiente, a partir de la lectura del registro realizado con el DMTE y de un ECG de 12 derivaciones. Resultados: participaron del estudio 114 beneficiarios del Plan Ibirapitá, 78 del sexo femenino. La edad fue de 72,5 ± 5,36 años (rango: 53-87 años). La sensibilidad para el diagnóstico de FA del DMTE fue de 100%, con una especificidad de 96,6%. (VPP = 57,1% VPN = 100%) y una proporción de diagnóstico correcto de 96,8%. El DMTE catalogó como \"sin clasificar\" al 18,4% de los trazados. Considerando esto, la proporción de diagnóstico correcto disminuyó a 78,9%, sin presentar falsos negativos. Conclusiones: el cribado de FA con la utilización de un DMTE en una población de adultos mayores es factible y confiable. El hallazgo de un 18,4% de trazados con diagnóstico automático \"sin clasificar\" hace necesario contar con recursos humanos calificados para realizar la confirmación diagnóstica en esos registros.","downloadable_attachments":[{"id":78852610,"asset_id":68346680,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":63647831,"first_name":"Ramón","last_name":"Álvarez-Vaz","domain_name":"udelar","page_name":"RamónÁlvarezVaz","display_name":"Ramón Álvarez-Vaz","profile_url":"https://udelar.academia.edu/Ram%C3%B3n%C3%81lvarezVaz?f_ri=43363","photo":"https://0.academia-photos.com/63647831/16523043/16857980/s65_ram_n.alvarez_vaz.jpg"},{"id":213061204,"first_name":"Virginia","last_name":"Estragó","domain_name":"independent","page_name":"VirginiaEstragó","display_name":"Virginia Estragó","profile_url":"https://independent.academia.edu/VirginiaEstrag%C3%B3?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":24377,"name":"Mortality","url":"https://www.academia.edu/Documents/in/Mortality?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":130890,"name":"Atrial Fibrillation","url":"https://www.academia.edu/Documents/in/Atrial_Fibrillation?f_ri=43363","nofollow":true},{"id":399434,"name":"Morbidity","url":"https://www.academia.edu/Documents/in/Morbidity?f_ri=43363","nofollow":true},{"id":1277964,"name":"Electronics Technology","url":"https://www.academia.edu/Documents/in/Electronics_Technology?f_ri=43363"},{"id":1315993,"name":"Telemedicine, E-health, Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Telemedicine_E-health_Biomedical_Engineering?f_ri=43363"},{"id":1557549,"name":"Cardiovascular prevention","url":"https://www.academia.edu/Documents/in/Cardiovascular_prevention?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_67900136" data-work_id="67900136" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/67900136/Identification_of_novel_rapamycin_derivatives_as_low_level_impurities_in_active_pharmaceutical_ingredients">Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We describe the identification of novel rapamycin derivatives present as low-level impurities in active pharmaceutical ingredients using an integrated, multidisciplinary approach. Rapamycin, a fermentation-derived natural product is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_67900136" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We describe the identification of novel rapamycin derivatives present as low-level impurities in active pharmaceutical ingredients using an integrated, multidisciplinary approach. Rapamycin, a fermentation-derived natural product is itself used clinically and provides the starting material for several rapamycin analog drugs, typically used in oncology. LC-MS proved a sensitive means to analyze impurity profiles in batches of rapamycin. MS fragmentation was used to gain structural insight into these impurities, usually fermentation by-products, structurally very similar to rapamycin. In cases where MS fragmentation was unable to provide unambiguous structural identification, the impurities were isolated and purified using orthogonal HPLC methods. Using the higher mass sensitivity of small-volume NMR microprobes, submilligram amounts of isolated impurities were sufficient for further characterization by multidimensional NMR spectroscopy. Full assignment of the 1 H and 13 C NMR signals revealed the structure of these impurities at an atomic level. This systematic workflow enabled the identification of several novel rapamycin congeners from active pharmaceutical ingredient without the need for large-scale isolation of impurities. For illustration, two novel rapamycin derivatives are described in this study: 12-ethyl-rapamycin and 33-ethyl-rapamycin, which exemplify previously unreported modifications on the carbon skeleton of the rapamycin macrocycle. The methodologies described here can be of wide use for identification of closely related structures found; for example as fermentation by-products, metabolites or degradants of natural product-based drugs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67900136" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b7c21b919d8b0cc83c4c763a1c381a55" rel="nofollow" data-download="{"attachment_id":78574813,"asset_id":67900136,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78574813/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39702796" href="https://independent.academia.edu/StephanZech">Stephan Zech</a><script data-card-contents-for-user="39702796" type="text/json">{"id":39702796,"first_name":"Stephan","last_name":"Zech","domain_name":"independent","page_name":"StephanZech","display_name":"Stephan Zech","profile_url":"https://independent.academia.edu/StephanZech?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_67900136 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67900136"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67900136, container: ".js-paper-rank-work_67900136", }); 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$(".js-view-count[data-work-id=67900136]").text(description); $(".js-view-count-work_67900136").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67900136").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67900136"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="159" rel="nofollow" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a>, <script data-card-contents-for-ri="159" type="text/json">{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="5769" rel="nofollow" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7076" rel="nofollow" href="https://www.academia.edu/Documents/in/Taxonomy">Taxonomy</a><script data-card-contents-for-ri="7076" type="text/json">{"id":7076,"name":"Taxonomy","url":"https://www.academia.edu/Documents/in/Taxonomy?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67900136]'), work: {"id":67900136,"title":"Identification of novel rapamycin derivatives as low-level impurities in active pharmaceutical ingredients","created_at":"2022-01-12T22:15:07.471-08:00","url":"https://www.academia.edu/67900136/Identification_of_novel_rapamycin_derivatives_as_low_level_impurities_in_active_pharmaceutical_ingredients?f_ri=43363","dom_id":"work_67900136","summary":"We describe the identification of novel rapamycin derivatives present as low-level impurities in active pharmaceutical ingredients using an integrated, multidisciplinary approach. Rapamycin, a fermentation-derived natural product is itself used clinically and provides the starting material for several rapamycin analog drugs, typically used in oncology. LC-MS proved a sensitive means to analyze impurity profiles in batches of rapamycin. MS fragmentation was used to gain structural insight into these impurities, usually fermentation by-products, structurally very similar to rapamycin. In cases where MS fragmentation was unable to provide unambiguous structural identification, the impurities were isolated and purified using orthogonal HPLC methods. Using the higher mass sensitivity of small-volume NMR microprobes, submilligram amounts of isolated impurities were sufficient for further characterization by multidimensional NMR spectroscopy. Full assignment of the 1 H and 13 C NMR signals revealed the structure of these impurities at an atomic level. This systematic workflow enabled the identification of several novel rapamycin congeners from active pharmaceutical ingredient without the need for large-scale isolation of impurities. For illustration, two novel rapamycin derivatives are described in this study: 12-ethyl-rapamycin and 33-ethyl-rapamycin, which exemplify previously unreported modifications on the carbon skeleton of the rapamycin macrocycle. The methodologies described here can be of wide use for identification of closely related structures found; for example as fermentation by-products, metabolites or degradants of natural product-based drugs.","downloadable_attachments":[{"id":78574813,"asset_id":67900136,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39702796,"first_name":"Stephan","last_name":"Zech","domain_name":"independent","page_name":"StephanZech","display_name":"Stephan Zech","profile_url":"https://independent.academia.edu/StephanZech?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology?f_ri=43363","nofollow":true},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=43363","nofollow":true},{"id":7076,"name":"Taxonomy","url":"https://www.academia.edu/Documents/in/Taxonomy?f_ri=43363","nofollow":true},{"id":12134,"name":"NMR Spectroscopy","url":"https://www.academia.edu/Documents/in/NMR_Spectroscopy?f_ri=43363"},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance?f_ri=43363"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry?f_ri=43363"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry?f_ri=43363"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography?f_ri=43363"},{"id":758278,"name":"Large Scale","url":"https://www.academia.edu/Documents/in/Large_Scale?f_ri=43363"},{"id":816534,"name":"Multidisciplinary Approach","url":"https://www.academia.edu/Documents/in/Multidisciplinary_Approach?f_ri=43363"},{"id":1126207,"name":"Active Pharmaceutical Ingredient","url":"https://www.academia.edu/Documents/in/Active_Pharmaceutical_Ingredient?f_ri=43363"},{"id":1150115,"name":"Sirolimus","url":"https://www.academia.edu/Documents/in/Sirolimus?f_ri=43363"},{"id":1765959,"name":"Pharmaceutical Formulation","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Formulation?f_ri=43363"},{"id":2380004,"name":"Pharmaceutical preparations","url":"https://www.academia.edu/Documents/in/Pharmaceutical_preparations?f_ri=43363"},{"id":2562545,"name":"Glycopeptides","url":"https://www.academia.edu/Documents/in/Glycopeptides?f_ri=43363"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_35221342" data-work_id="35221342" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35221342/Development_and_initial_validation_of_the_Gilboa_functional_test_GIFT_A_unique_measure_for_preschool_graphomotor_screening">Development and initial validation of the Gilboa functional test (GIFT): A unique measure for preschool graphomotor screening</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: Fine motor and graphomotor skills are essential for children's healthy development, as well as for successful participation in everyday activities. The Gilboa functional test (GIFT) is a newly developed norm-referenced... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_35221342" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: Fine motor and graphomotor skills are essential for children's healthy development, as well as for successful participation in everyday activities. The Gilboa functional test (GIFT) is a newly developed norm-referenced screening instrument for use with children 3–6 years old. The aim of this study was to develop and validate the GIFT as a new measure for preschool graphomotor screening. Method: A community-based sample of 611 children aged 3–6 years was screened. Findings: Content validity was established via a panel of experts. The GIFT demonstrated good test–retest (0.95) and inter-rater reliability (0.94), demonstrating good concurrent validity in scores which significantly correlated with the Beery-VMI (r ¼ 0.32, P < 0.05), the Beery-MC (r ¼ 0.33, P < 0.05), the 'manual dexterity' subcategory of the movement assessment battery for children (r ¼ –0.364, P < 0.05) and the total score of the developmental coordination disorder questionnaire '07 (DCDQ'07)/little DCDQ (r ¼ 0.41, P < 0.01). A significant difference in total GIFT scoring was found between children from mainstream versus special education preschools (t ¼ 3.99, P < 0.001). Conclusion: The GIFT is a unique tool that measures performance skills based on preschool children's everyday activities. It can be used by paediatric occupational therapists as a first step for early identification of children potentially at risk for graphomotor/fine motor developmental delay.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/35221342" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a51bbee7f1e284657288bd16d7eb5594" rel="nofollow" data-download="{"attachment_id":55081018,"asset_id":35221342,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/55081018/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47517371" href="https://huji.academia.edu/YGilboa">Yafit Gilboa</a><script data-card-contents-for-user="47517371" type="text/json">{"id":47517371,"first_name":"Yafit","last_name":"Gilboa","domain_name":"huji","page_name":"YGilboa","display_name":"Yafit Gilboa","profile_url":"https://huji.academia.edu/YGilboa?f_ri=43363","photo":"https://0.academia-photos.com/47517371/19512492/19418902/s65_yafit.gilboa.jpg"}</script></span></span></li><li class="js-paper-rank-work_35221342 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="35221342"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 35221342, container: ".js-paper-rank-work_35221342", }); 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$(".js-view-count[data-work-id=35221342]").text(description); $(".js-view-count-work_35221342").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_35221342").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="35221342"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1750" rel="nofollow" href="https://www.academia.edu/Documents/in/Assessment">Assessment</a>, <script data-card-contents-for-ri="1750" type="text/json">{"id":1750,"name":"Assessment","url":"https://www.academia.edu/Documents/in/Assessment?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2247" rel="nofollow" href="https://www.academia.edu/Documents/in/Occupational_Therapy">Occupational Therapy</a>, <script data-card-contents-for-ri="2247" type="text/json">{"id":2247,"name":"Occupational Therapy","url":"https://www.academia.edu/Documents/in/Occupational_Therapy?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4583" rel="nofollow" href="https://www.academia.edu/Documents/in/Child_Development">Child Development</a>, <script data-card-contents-for-ri="4583" type="text/json">{"id":4583,"name":"Child Development","url":"https://www.academia.edu/Documents/in/Child_Development?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=35221342]'), work: {"id":35221342,"title":"Development and initial validation of the Gilboa functional test (GIFT): A unique measure for preschool graphomotor screening","created_at":"2017-11-22T05:54:15.073-08:00","url":"https://www.academia.edu/35221342/Development_and_initial_validation_of_the_Gilboa_functional_test_GIFT_A_unique_measure_for_preschool_graphomotor_screening?f_ri=43363","dom_id":"work_35221342","summary":"Introduction: Fine motor and graphomotor skills are essential for children's healthy development, as well as for successful participation in everyday activities. The Gilboa functional test (GIFT) is a newly developed norm-referenced screening instrument for use with children 3–6 years old. The aim of this study was to develop and validate the GIFT as a new measure for preschool graphomotor screening. Method: A community-based sample of 611 children aged 3–6 years was screened. Findings: Content validity was established via a panel of experts. The GIFT demonstrated good test–retest (0.95) and inter-rater reliability (0.94), demonstrating good concurrent validity in scores which significantly correlated with the Beery-VMI (r ¼ 0.32, P \u003c 0.05), the Beery-MC (r ¼ 0.33, P \u003c 0.05), the 'manual dexterity' subcategory of the movement assessment battery for children (r ¼ –0.364, P \u003c 0.05) and the total score of the developmental coordination disorder questionnaire '07 (DCDQ'07)/little DCDQ (r ¼ 0.41, P \u003c 0.01). A significant difference in total GIFT scoring was found between children from mainstream versus special education preschools (t ¼ 3.99, P \u003c 0.001). Conclusion: The GIFT is a unique tool that measures performance skills based on preschool children's everyday activities. It can be used by paediatric occupational therapists as a first step for early identification of children potentially at risk for graphomotor/fine motor developmental delay.","downloadable_attachments":[{"id":55081018,"asset_id":35221342,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47517371,"first_name":"Yafit","last_name":"Gilboa","domain_name":"huji","page_name":"YGilboa","display_name":"Yafit Gilboa","profile_url":"https://huji.academia.edu/YGilboa?f_ri=43363","photo":"https://0.academia-photos.com/47517371/19512492/19418902/s65_yafit.gilboa.jpg"}],"research_interests":[{"id":1750,"name":"Assessment","url":"https://www.academia.edu/Documents/in/Assessment?f_ri=43363","nofollow":true},{"id":2247,"name":"Occupational Therapy","url":"https://www.academia.edu/Documents/in/Occupational_Therapy?f_ri=43363","nofollow":true},{"id":4583,"name":"Child Development","url":"https://www.academia.edu/Documents/in/Child_Development?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_35019631" data-work_id="35019631" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35019631/The_Pregnancy_Depression_Scale_PDS_a_screening_tool_for_depression_in_pregnancy">The Pregnancy Depression Scale (PDS): a screening tool for depression in pregnancy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Depression in pregnancy can be underdiagnosed as a consequence of the symptoms being misattributed to "normal pregnancy." There are currently no validated clinician-rated scales that assess for depression specifically during pregnancy. We... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_35019631" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Depression in pregnancy can be underdiagnosed as a consequence of the symptoms being misattributed to "normal pregnancy." There are currently no validated clinician-rated scales that assess for depression specifically during pregnancy. We sought to develop a brief, convenient screening tool to identify depression in pregnant women in the community setting. Prospective mood data using the 28item Hamilton Depression Rating Scale (HDRS) were collected monthly in 196 pregnant women with a history of a major depressive disorder. These data were analyzed to delineate those HDRS items associated (elevated) with normal pregnancy vs. those indicative of a pregnant woman meeting diagnostic criteria for a major depressive episode. Endorsement of symptoms on seven items of the HDRS were highly predictive of having a major depressive episode during pregnancy. We present a well-validated, brief scale to screen pregnant women for clinical depression. Whether this study will generalize to women who do not have a history of major depression remains to be studied.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/35019631" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ff659eefd58590656622b68ea88cf3c2" rel="nofollow" data-download="{"attachment_id":54883229,"asset_id":35019631,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54883229/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32671888" href="https://upstate.academia.edu/StephenFaraone">Stephen V Faraone</a><script data-card-contents-for-user="32671888" type="text/json">{"id":32671888,"first_name":"Stephen","last_name":"Faraone","domain_name":"upstate","page_name":"StephenFaraone","display_name":"Stephen V Faraone","profile_url":"https://upstate.academia.edu/StephenFaraone?f_ri=43363","photo":"https://0.academia-photos.com/32671888/18362818/18322077/s65_stephen.faraone.jpg"}</script></span></span></li><li class="js-paper-rank-work_35019631 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="35019631"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 35019631, container: ".js-paper-rank-work_35019631", }); 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$(".js-view-count[data-work-id=35019631]").text(description); $(".js-view-count-work_35019631").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_35019631").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="35019631"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3217" rel="nofollow" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" rel="nofollow" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=35019631]'), work: {"id":35019631,"title":"The Pregnancy Depression Scale (PDS): a screening tool for depression in pregnancy","created_at":"2017-11-01T04:58:26.981-07:00","url":"https://www.academia.edu/35019631/The_Pregnancy_Depression_Scale_PDS_a_screening_tool_for_depression_in_pregnancy?f_ri=43363","dom_id":"work_35019631","summary":"Depression in pregnancy can be underdiagnosed as a consequence of the symptoms being misattributed to \"normal pregnancy.\" There are currently no validated clinician-rated scales that assess for depression specifically during pregnancy. We sought to develop a brief, convenient screening tool to identify depression in pregnant women in the community setting. Prospective mood data using the 28item Hamilton Depression Rating Scale (HDRS) were collected monthly in 196 pregnant women with a history of a major depressive disorder. These data were analyzed to delineate those HDRS items associated (elevated) with normal pregnancy vs. those indicative of a pregnant woman meeting diagnostic criteria for a major depressive episode. Endorsement of symptoms on seven items of the HDRS were highly predictive of having a major depressive episode during pregnancy. We present a well-validated, brief scale to screen pregnant women for clinical depression. Whether this study will generalize to women who do not have a history of major depression remains to be studied.","downloadable_attachments":[{"id":54883229,"asset_id":35019631,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32671888,"first_name":"Stephen","last_name":"Faraone","domain_name":"upstate","page_name":"StephenFaraone","display_name":"Stephen V Faraone","profile_url":"https://upstate.academia.edu/StephenFaraone?f_ri=43363","photo":"https://0.academia-photos.com/32671888/18362818/18322077/s65_stephen.faraone.jpg"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=43363","nofollow":true},{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=43363","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=43363","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=43363"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=43363"},{"id":77794,"name":"Major Depressive Disorder","url":"https://www.academia.edu/Documents/in/Major_Depressive_Disorder?f_ri=43363"},{"id":245071,"name":"Rating Scale","url":"https://www.academia.edu/Documents/in/Rating_Scale?f_ri=43363"},{"id":311947,"name":"Major Depression","url":"https://www.academia.edu/Documents/in/Major_Depression?f_ri=43363"},{"id":486566,"name":"Pregnant Women","url":"https://www.academia.edu/Documents/in/Pregnant_Women?f_ri=43363"},{"id":2330264,"name":"Diagnostic Criteria","url":"https://www.academia.edu/Documents/in/Diagnostic_Criteria?f_ri=43363"},{"id":2507648,"name":"Hamilton Depression Rating Scale","url":"https://www.academia.edu/Documents/in/Hamilton_Depression_Rating_Scale?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30529050" data-work_id="30529050" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30529050/Challenges_and_Rewards_of_Research_in_Marine_Natural_Products_Chemistry_in_Brazil_">Challenges and Rewards of Research in Marine Natural Products Chemistry in Brazil #</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Brazil is blessed with a great biodiversity, which constitutes one of the most important sources of biologically active compounds, even if it has been largely underexplored. As is the case of the Amazon and Atlantic rainforests, the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30529050" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Brazil is blessed with a great biodiversity, which constitutes one of the most important sources of biologically active compounds, even if it has been largely underexplored. As is the case of the Amazon and Atlantic rainforests, the Brazilian marine fauna remains practically unexplored in the search for new biologically active natural products. Considering that marine organisms have been shown to be one of the most promising sources of new bioactive compounds for the treatment of different human diseases, the 8000 km of the Brazilian coastline represents a great potential for finding new pharmacologically active secondary metabolites. This review presents the status of marine natural products chemistry in Brazil, including results reported by different research groups with emphasis on the isolation, structure elucidation, and evaluation of biological activities of natural products isolated from sponges, ascidians, octocorals, and Opistobranch mollusks. A brief overview of the first Brazilian program on the isolation of marine bacteria and fungi, directed toward the production of biologically active compounds, is also discussed. The current multidisciplinary collaborative program under development at the Universidade de Sã o Paulo proposes to establish a new paradigm toward the management of the Brazilian marine biodiversity, integrating research on the species diversity, ecology, taxonomy, and biogeography of marine invertebrates and microorganisms. This program also includes a broad screening program of Brazilian marine bioresources, to search for active compounds that may be of interest for the development of new drug leads.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30529050" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1be415dcf9eb2aef0a25b65e9681c4cc" rel="nofollow" data-download="{"attachment_id":50972294,"asset_id":30529050,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50972294/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58188214" href="https://independent.academia.edu/SouzaAnaCristinade">Ana Cristina de Souza</a><script data-card-contents-for-user="58188214" type="text/json">{"id":58188214,"first_name":"Ana Cristina de","last_name":"Souza","domain_name":"independent","page_name":"SouzaAnaCristinade","display_name":"Ana Cristina de Souza","profile_url":"https://independent.academia.edu/SouzaAnaCristinade?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30529050 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30529050"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30529050, container: ".js-paper-rank-work_30529050", }); 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$(".js-view-count[data-work-id=30529050]").text(description); $(".js-view-count-work_30529050").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30529050").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30529050"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="158" rel="nofollow" href="https://www.academia.edu/Documents/in/Marine_Biology">Marine Biology</a>, <script data-card-contents-for-ri="158" type="text/json">{"id":158,"name":"Marine Biology","url":"https://www.academia.edu/Documents/in/Marine_Biology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2168" rel="nofollow" href="https://www.academia.edu/Documents/in/Natural_Products">Natural Products</a>, <script data-card-contents-for-ri="2168" type="text/json">{"id":2168,"name":"Natural Products","url":"https://www.academia.edu/Documents/in/Natural_Products?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9821" rel="nofollow" href="https://www.academia.edu/Documents/in/Brazil">Brazil</a>, <script data-card-contents-for-ri="9821" type="text/json">{"id":9821,"name":"Brazil","url":"https://www.academia.edu/Documents/in/Brazil?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24567" rel="nofollow" href="https://www.academia.edu/Documents/in/Porifera">Porifera</a><script data-card-contents-for-ri="24567" type="text/json">{"id":24567,"name":"Porifera","url":"https://www.academia.edu/Documents/in/Porifera?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30529050]'), work: {"id":30529050,"title":"Challenges and Rewards of Research in Marine Natural Products Chemistry in Brazil #","created_at":"2016-12-19T11:49:47.769-08:00","url":"https://www.academia.edu/30529050/Challenges_and_Rewards_of_Research_in_Marine_Natural_Products_Chemistry_in_Brazil_?f_ri=43363","dom_id":"work_30529050","summary":"Brazil is blessed with a great biodiversity, which constitutes one of the most important sources of biologically active compounds, even if it has been largely underexplored. As is the case of the Amazon and Atlantic rainforests, the Brazilian marine fauna remains practically unexplored in the search for new biologically active natural products. Considering that marine organisms have been shown to be one of the most promising sources of new bioactive compounds for the treatment of different human diseases, the 8000 km of the Brazilian coastline represents a great potential for finding new pharmacologically active secondary metabolites. This review presents the status of marine natural products chemistry in Brazil, including results reported by different research groups with emphasis on the isolation, structure elucidation, and evaluation of biological activities of natural products isolated from sponges, ascidians, octocorals, and Opistobranch mollusks. A brief overview of the first Brazilian program on the isolation of marine bacteria and fungi, directed toward the production of biologically active compounds, is also discussed. The current multidisciplinary collaborative program under development at the Universidade de Sã o Paulo proposes to establish a new paradigm toward the management of the Brazilian marine biodiversity, integrating research on the species diversity, ecology, taxonomy, and biogeography of marine invertebrates and microorganisms. This program also includes a broad screening program of Brazilian marine bioresources, to search for active compounds that may be of interest for the development of new drug leads.","downloadable_attachments":[{"id":50972294,"asset_id":30529050,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":58188214,"first_name":"Ana Cristina de","last_name":"Souza","domain_name":"independent","page_name":"SouzaAnaCristinade","display_name":"Ana Cristina de Souza","profile_url":"https://independent.academia.edu/SouzaAnaCristinade?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":158,"name":"Marine Biology","url":"https://www.academia.edu/Documents/in/Marine_Biology?f_ri=43363","nofollow":true},{"id":2168,"name":"Natural Products","url":"https://www.academia.edu/Documents/in/Natural_Products?f_ri=43363","nofollow":true},{"id":9821,"name":"Brazil","url":"https://www.academia.edu/Documents/in/Brazil?f_ri=43363","nofollow":true},{"id":24567,"name":"Porifera","url":"https://www.academia.edu/Documents/in/Porifera?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=43363"},{"id":77753,"name":"Anthozoa","url":"https://www.academia.edu/Documents/in/Anthozoa?f_ri=43363"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria?f_ri=43363"},{"id":175619,"name":"Mollusca","url":"https://www.academia.edu/Documents/in/Mollusca?f_ri=43363"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=43363"},{"id":309895,"name":"Isolation","url":"https://www.academia.edu/Documents/in/Isolation?f_ri=43363"},{"id":460256,"name":"Natural","url":"https://www.academia.edu/Documents/in/Natural?f_ri=43363"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=43363"},{"id":971822,"name":"Active Ingredient","url":"https://www.academia.edu/Documents/in/Active_Ingredient?f_ri=43363"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure?f_ri=43363"},{"id":1851532,"name":"Marine Natural Product","url":"https://www.academia.edu/Documents/in/Marine_Natural_Product?f_ri=43363"},{"id":2142568,"name":"Thallophyta","url":"https://www.academia.edu/Documents/in/Thallophyta?f_ri=43363"},{"id":2380004,"name":"Pharmaceutical preparations","url":"https://www.academia.edu/Documents/in/Pharmaceutical_preparations?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21274804" data-work_id="21274804" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21274804/Automated_analysis_of_behavior_A_computer_controlled_system_for_drug_screening_and_the_investigation_of_learning">Automated analysis of behavior: A computer-controlled system for drug screening and the investigation of learning</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Efforts to understand cognition will be greatly facilitated by computerized systems that enable the automated analysis of animal behavior. A number of controversies in the invertebrate learning field have resulted from difficulties... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21274804" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Efforts to understand cognition will be greatly facilitated by computerized systems that enable the automated analysis of animal behavior. A number of controversies in the invertebrate learning field have resulted from difficulties inherent in manual experiments. Driven by the necessity to overcome these problems during investigation of neural function in planarian flatworms and frog larvae, we designed and developed a prototype for an inexpensive, flexible system that enables automated control and analysis of behavior and learning. Applicable to a variety of small animals such as flatworms and zebrafish, this system allows automated analysis of innate behavior, as well as of learning and memory in a plethora of conditioning paradigms. We present here the schematics of a basic prototype, which overcomes experimenter effects and operator tedium, enabling a large number of animals to be analyzed with transparent on-line access to primary data. A scaled-up version of this technology represents an efficient methodology to screen pharmacological and genetic libraries for novel neuroactive reagents of basic and biomedical relevance. '</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21274804" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="122c8abde0ad12f5c0a682e292b4a24d" rel="nofollow" data-download="{"attachment_id":41793807,"asset_id":21274804,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41793807/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42393317" href="https://johnshopkins.academia.edu/CaitlinHicks">Caitlin Hicks</a><script data-card-contents-for-user="42393317" type="text/json">{"id":42393317,"first_name":"Caitlin","last_name":"Hicks","domain_name":"johnshopkins","page_name":"CaitlinHicks","display_name":"Caitlin Hicks","profile_url":"https://johnshopkins.academia.edu/CaitlinHicks?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21274804 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21274804"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21274804, container: ".js-paper-rank-work_21274804", }); 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$(".js-view-count[data-work-id=21274804]").text(description); $(".js-view-count-work_21274804").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21274804").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21274804"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">21</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2749" rel="nofollow" href="https://www.academia.edu/Documents/in/Animal_Behavior">Animal Behavior</a>, <script data-card-contents-for-ri="2749" type="text/json">{"id":2749,"name":"Animal Behavior","url":"https://www.academia.edu/Documents/in/Animal_Behavior?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a><script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21274804]'), work: {"id":21274804,"title":"Automated analysis of behavior: A computer-controlled system for drug screening and the investigation of learning","created_at":"2016-01-30T19:53:58.091-08:00","url":"https://www.academia.edu/21274804/Automated_analysis_of_behavior_A_computer_controlled_system_for_drug_screening_and_the_investigation_of_learning?f_ri=43363","dom_id":"work_21274804","summary":"Efforts to understand cognition will be greatly facilitated by computerized systems that enable the automated analysis of animal behavior. A number of controversies in the invertebrate learning field have resulted from difficulties inherent in manual experiments. Driven by the necessity to overcome these problems during investigation of neural function in planarian flatworms and frog larvae, we designed and developed a prototype for an inexpensive, flexible system that enables automated control and analysis of behavior and learning. Applicable to a variety of small animals such as flatworms and zebrafish, this system allows automated analysis of innate behavior, as well as of learning and memory in a plethora of conditioning paradigms. We present here the schematics of a basic prototype, which overcomes experimenter effects and operator tedium, enabling a large number of animals to be analyzed with transparent on-line access to primary data. A scaled-up version of this technology represents an efficient methodology to screen pharmacological and genetic libraries for novel neuroactive reagents of basic and biomedical relevance. '","downloadable_attachments":[{"id":41793807,"asset_id":21274804,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42393317,"first_name":"Caitlin","last_name":"Hicks","domain_name":"johnshopkins","page_name":"CaitlinHicks","display_name":"Caitlin Hicks","profile_url":"https://johnshopkins.academia.edu/CaitlinHicks?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=43363","nofollow":true},{"id":2749,"name":"Animal Behavior","url":"https://www.academia.edu/Documents/in/Animal_Behavior?f_ri=43363","nofollow":true},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=43363","nofollow":true},{"id":25804,"name":"Neurobiology","url":"https://www.academia.edu/Documents/in/Neurobiology?f_ri=43363"},{"id":31514,"name":"Behavior Analysis","url":"https://www.academia.edu/Documents/in/Behavior_Analysis?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning?f_ri=43363"},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=43363"},{"id":58513,"name":"Learning and Memory","url":"https://www.academia.edu/Documents/in/Learning_and_Memory-1?f_ri=43363"},{"id":59249,"name":"Computers","url":"https://www.academia.edu/Documents/in/Computers?f_ri=43363"},{"id":66379,"name":"Automation","url":"https://www.academia.edu/Documents/in/Automation?f_ri=43363"},{"id":119665,"name":"Reaction Time","url":"https://www.academia.edu/Documents/in/Reaction_Time?f_ri=43363"},{"id":122642,"name":"Drug Screening","url":"https://www.academia.edu/Documents/in/Drug_Screening?f_ri=43363"},{"id":128057,"name":"Light","url":"https://www.academia.edu/Documents/in/Light?f_ri=43363"},{"id":161282,"name":"Scaling up","url":"https://www.academia.edu/Documents/in/Scaling_up?f_ri=43363"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=43363"},{"id":202574,"name":"Feeding Behavior","url":"https://www.academia.edu/Documents/in/Feeding_Behavior?f_ri=43363"},{"id":413487,"name":"Design and Development","url":"https://www.academia.edu/Documents/in/Design_and_Development?f_ri=43363"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=43363"},{"id":1757008,"name":"Planarians","url":"https://www.academia.edu/Documents/in/Planarians?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15311216" data-work_id="15311216" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15311216/Guidelines">Guidelines</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Age 21. Women aged <21 years should not be screened regardless of the age of sexual initiation or other risk factors. (Strong recommendation) Age 21. (A recommendation) Recommend against screening women aged <21 years. (D recommendation)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15311216" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Age 21. Women aged <21 years should not be screened regardless of the age of sexual initiation or other risk factors. (Strong recommendation) Age 21. (A recommendation) Recommend against screening women aged <21 years. (D recommendation) Age 21 regardless of the age of onset of sexual activity. Women aged <21 years should not be screened regardless of age at sexual initiation and other behavior-related risk factors. (Level A evidence) Statement about annual screening Women of any age should not be screened annually by any screening method. (Strong recommendation)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15311216" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="70cbee416a3e19bd2e4c088dac7b0af7" rel="nofollow" data-download="{"attachment_id":38628664,"asset_id":15311216,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38628664/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34414902" href="https://independent.academia.edu/ReyKumampung">Rey Kumampung</a><script data-card-contents-for-user="34414902" type="text/json">{"id":34414902,"first_name":"Rey","last_name":"Kumampung","domain_name":"independent","page_name":"ReyKumampung","display_name":"Rey Kumampung","profile_url":"https://independent.academia.edu/ReyKumampung?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15311216 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15311216"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15311216, container: ".js-paper-rank-work_15311216", }); 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$(".js-view-count[data-work-id=15311216]").text(description); $(".js-view-count-work_15311216").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15311216").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15311216"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1085" rel="nofollow" href="https://www.academia.edu/Documents/in/Epidemiology">Epidemiology</a>, <script data-card-contents-for-ri="1085" type="text/json">{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8882" rel="nofollow" href="https://www.academia.edu/Documents/in/Women">Women</a>, <script data-card-contents-for-ri="8882" type="text/json">{"id":8882,"name":"Women","url":"https://www.academia.edu/Documents/in/Women?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="14195" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer_Biology">Cancer Biology</a><script data-card-contents-for-ri="14195" type="text/json">{"id":14195,"name":"Cancer Biology","url":"https://www.academia.edu/Documents/in/Cancer_Biology?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15311216]'), work: {"id":15311216,"title":"Guidelines","created_at":"2015-08-31T19:22:38.431-07:00","url":"https://www.academia.edu/15311216/Guidelines?f_ri=43363","dom_id":"work_15311216","summary":"Age 21. Women aged \u003c21 years should not be screened regardless of the age of sexual initiation or other risk factors. (Strong recommendation) Age 21. (A recommendation) Recommend against screening women aged \u003c21 years. (D recommendation) Age 21 regardless of the age of onset of sexual activity. Women aged \u003c21 years should not be screened regardless of age at sexual initiation and other behavior-related risk factors. (Level A evidence) Statement about annual screening Women of any age should not be screened annually by any screening method. (Strong recommendation)","downloadable_attachments":[{"id":38628664,"asset_id":15311216,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34414902,"first_name":"Rey","last_name":"Kumampung","domain_name":"independent","page_name":"ReyKumampung","display_name":"Rey Kumampung","profile_url":"https://independent.academia.edu/ReyKumampung?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=43363","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=43363","nofollow":true},{"id":8882,"name":"Women","url":"https://www.academia.edu/Documents/in/Women?f_ri=43363","nofollow":true},{"id":14195,"name":"Cancer Biology","url":"https://www.academia.edu/Documents/in/Cancer_Biology?f_ri=43363","nofollow":true},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":235465,"name":"Guidelines","url":"https://www.academia.edu/Documents/in/Guidelines?f_ri=43363"},{"id":485892,"name":"CDC","url":"https://www.academia.edu/Documents/in/CDC?f_ri=43363"},{"id":723148,"name":"Cervical","url":"https://www.academia.edu/Documents/in/Cervical?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13882984" data-work_id="13882984" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13882984/Neonatal_PKU_screening_in_Turkey_7_years_experience_in_a_developing_country">Neonatal PKU screening in Turkey: 7 years experience in a developing country</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: This report describes the system of neonatal screening for phenylketonuria (PKU) that has been developed in Turkey and the results of screening. Methods: A total of 576 122 newborns born in maternity hospitals in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13882984" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: This report describes the system of neonatal screening for phenylketonuria (PKU) that has been developed in Turkey and the results of screening. Methods: A total of 576 122 newborns born in maternity hospitals in metropolitan districts of the cities were screened using the Guthrie bacterial inhibition test. Classification of PKU or non-PKU hyperphenylalaninemia was determined by the confirmatory serum phenylalanine level and/or subsequent protein loading test. Results: One hundred and forty-two cases with persistent hyperphenylalaninemia were detected (1:4500). In 96 of these cases confirmatory tests were found to be compatible with PKU (15000) and the remaining 46 cases had either mild or moderate hyperphenylalaninemia. In one patient, the hyperphenylalaninemia was secondary to a pterin defect (dihydropteridine reductase deficiency). The ratio of PKU/non-PKU hyperphenylalaninemia was 2.0. Discussion: The major problems encountered in the screening program and in management of the detected cases were unsatisfactory sample collection, early discharge from maternity hospitals, difficulties in reaching some of the detected cases, noncompliance with dietary therapy due to illiterate parents or in families without social insurance. The health system in Turkey seems to require a second blood sampling for PKU screening obtainable in Maternal and Child Health care units in the cities and by midwives in rural areas. In Turkey, with an exceptionally high frequency of PKU, prenatal diagnosis for PKU should be combined with the neonatal screening program. Keywordr: Phenylketonuria; Neonatal screening; Screening problems l Corresponding author. 092%6164/95/$09.50 0 1995 Elsevier Science Ireland Ltd. AII rights reserved SSDI 0925-6164(95)00125-6</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13882984" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="28bed89d8c5bf815dc38d2c33ddb872b" rel="nofollow" data-download="{"attachment_id":44840125,"asset_id":13882984,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44840125/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32960289" href="https://independent.academia.edu/MeralOzg%C3%BC%C3%A7">Meral Ozgüç</a><script data-card-contents-for-user="32960289" type="text/json">{"id":32960289,"first_name":"Meral","last_name":"Ozgüç","domain_name":"independent","page_name":"MeralOzgüç","display_name":"Meral Ozgüç","profile_url":"https://independent.academia.edu/MeralOzg%C3%BC%C3%A7?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13882984 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13882984"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13882984, container: ".js-paper-rank-work_13882984", }); 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$(".js-view-count[data-work-id=13882984]").text(description); $(".js-view-count-work_13882984").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13882984").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13882984"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4960" rel="nofollow" href="https://www.academia.edu/Documents/in/Social_Insurance">Social Insurance</a>, <script data-card-contents-for-ri="4960" type="text/json">{"id":4960,"name":"Social Insurance","url":"https://www.academia.edu/Documents/in/Social_Insurance?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="48458" rel="nofollow" href="https://www.academia.edu/Documents/in/High_Frequency">High Frequency</a>, <script data-card-contents-for-ri="48458" type="text/json">{"id":48458,"name":"High Frequency","url":"https://www.academia.edu/Documents/in/High_Frequency?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51665" rel="nofollow" href="https://www.academia.edu/Documents/in/Maternal_and_Child_Health">Maternal and Child Health</a><script data-card-contents-for-ri="51665" type="text/json">{"id":51665,"name":"Maternal and Child Health","url":"https://www.academia.edu/Documents/in/Maternal_and_Child_Health?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13882984]'), work: {"id":13882984,"title":"Neonatal PKU screening in Turkey: 7 years experience in a developing country","created_at":"2015-07-10T06:28:25.462-07:00","url":"https://www.academia.edu/13882984/Neonatal_PKU_screening_in_Turkey_7_years_experience_in_a_developing_country?f_ri=43363","dom_id":"work_13882984","summary":"Introduction: This report describes the system of neonatal screening for phenylketonuria (PKU) that has been developed in Turkey and the results of screening. Methods: A total of 576 122 newborns born in maternity hospitals in metropolitan districts of the cities were screened using the Guthrie bacterial inhibition test. Classification of PKU or non-PKU hyperphenylalaninemia was determined by the confirmatory serum phenylalanine level and/or subsequent protein loading test. Results: One hundred and forty-two cases with persistent hyperphenylalaninemia were detected (1:4500). In 96 of these cases confirmatory tests were found to be compatible with PKU (15000) and the remaining 46 cases had either mild or moderate hyperphenylalaninemia. In one patient, the hyperphenylalaninemia was secondary to a pterin defect (dihydropteridine reductase deficiency). The ratio of PKU/non-PKU hyperphenylalaninemia was 2.0. Discussion: The major problems encountered in the screening program and in management of the detected cases were unsatisfactory sample collection, early discharge from maternity hospitals, difficulties in reaching some of the detected cases, noncompliance with dietary therapy due to illiterate parents or in families without social insurance. The health system in Turkey seems to require a second blood sampling for PKU screening obtainable in Maternal and Child Health care units in the cities and by midwives in rural areas. In Turkey, with an exceptionally high frequency of PKU, prenatal diagnosis for PKU should be combined with the neonatal screening program. Keywordr: Phenylketonuria; Neonatal screening; Screening problems l Corresponding author. 092%6164/95/$09.50 0 1995 Elsevier Science Ireland Ltd. AII rights reserved SSDI 0925-6164(95)00125-6","downloadable_attachments":[{"id":44840125,"asset_id":13882984,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32960289,"first_name":"Meral","last_name":"Ozgüç","domain_name":"independent","page_name":"MeralOzgüç","display_name":"Meral Ozgüç","profile_url":"https://independent.academia.edu/MeralOzg%C3%BC%C3%A7?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4960,"name":"Social Insurance","url":"https://www.academia.edu/Documents/in/Social_Insurance?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":48458,"name":"High Frequency","url":"https://www.academia.edu/Documents/in/High_Frequency?f_ri=43363","nofollow":true},{"id":51665,"name":"Maternal and Child Health","url":"https://www.academia.edu/Documents/in/Maternal_and_Child_Health?f_ri=43363","nofollow":true},{"id":70854,"name":"Developing Country","url":"https://www.academia.edu/Documents/in/Developing_Country?f_ri=43363"},{"id":103298,"name":"Blood sampling","url":"https://www.academia.edu/Documents/in/Blood_sampling?f_ri=43363"},{"id":108569,"name":"Phenylketonuria","url":"https://www.academia.edu/Documents/in/Phenylketonuria?f_ri=43363"},{"id":245969,"name":"Health System","url":"https://www.academia.edu/Documents/in/Health_System?f_ri=43363"},{"id":554768,"name":"Prenatal Diagnosis","url":"https://www.academia.edu/Documents/in/Prenatal_Diagnosis?f_ri=43363"},{"id":647003,"name":"Rural Area","url":"https://www.academia.edu/Documents/in/Rural_Area?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_60906418" data-work_id="60906418" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/60906418/Susceptibility_of_I_Aethina_tumida_I_Coleoptera_Nitidulidae_Larvae_and_Pupae_to_Entomopathogenic_Nematodes">Susceptibility of <I>Aethina tumida</I> (Coleoptera: Nitidulidae) Larvae and Pupae to Entomopathogenic Nematodes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In this study, we evaluated the potential use of entomopathogenic nematodes as a control for the beetle Aethina tumida Murray (Coleoptera: Nitidulidae). In particular, we conducted 1) four screening bioassays to determine nematode (seven... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_60906418" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In this study, we evaluated the potential use of entomopathogenic nematodes as a control for the beetle Aethina tumida Murray (Coleoptera: Nitidulidae). In particular, we conducted 1) four screening bioassays to determine nematode (seven species, 10 total strains tested) and application level effects on A. tumida larvae and pupae, 2) a generational persistence bioassay to determine whether single inoculations with nematodes would control multiple generations of A. tumida larvae in treated soil, and 3) a Þeld bioassay to determine whether the nematodes would remain efÞcacious in the Þeld. In the screening bioassays, nematode efÞcacy varied signiÞcantly by tested nematode and the infective juvenile (IJ) level at which they were applied. Although nematode virulence was moderate in screening bioassays 1Ð3 (0 Ð 68% A. tumida mortality), A. tumida mortality approached higher levels in screening bioassay 4 (nearly 100% after 39 d) that suggest suitable applicability of some of the test nematodes as Þeld controls for A. tumida. In the generational persistence bioassay, Steinernema riobrave Cabanillas, Poinar & Raulston 7-12 strain and Heterorhabditis indica Poinar, Karunaka & David provided adequate A. tumida control for 19 wk after a single soil inoculation (76 Ð94% mortality in A. tumida pupae). In the Þeld bioassay, the same two nematode species also showed high virulence toward pupating A. tumida (88 Ð100%) mortality. Our data suggest that nematode use may be an integral component of an integrated pest management scheme aimed at reducing A. tumida populations in bee colonies to tolerable levels.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/60906418" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ab314b69a95419b11f8eff0483fe6516" rel="nofollow" data-download="{"attachment_id":74145998,"asset_id":60906418,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74145998/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37662099" href="https://independent.academia.edu/KeithDelaplane">Keith Delaplane</a><script data-card-contents-for-user="37662099" type="text/json">{"id":37662099,"first_name":"Keith","last_name":"Delaplane","domain_name":"independent","page_name":"KeithDelaplane","display_name":"Keith Delaplane","profile_url":"https://independent.academia.edu/KeithDelaplane?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_60906418 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="60906418"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 60906418, container: ".js-paper-rank-work_60906418", }); 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$(".js-view-count[data-work-id=60906418]").text(description); $(".js-view-count-work_60906418").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_60906418").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="60906418"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="173" rel="nofollow" href="https://www.academia.edu/Documents/in/Zoology">Zoology</a>, <script data-card-contents-for-ri="173" type="text/json">{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23516" rel="nofollow" href="https://www.academia.edu/Documents/in/Integrated_Pest_Management">Integrated Pest Management</a>, <script data-card-contents-for-ri="23516" type="text/json">{"id":23516,"name":"Integrated Pest Management","url":"https://www.academia.edu/Documents/in/Integrated_Pest_Management?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52873" rel="nofollow" href="https://www.academia.edu/Documents/in/Virulence">Virulence</a><script data-card-contents-for-ri="52873" type="text/json">{"id":52873,"name":"Virulence","url":"https://www.academia.edu/Documents/in/Virulence?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=60906418]'), work: {"id":60906418,"title":"Susceptibility of \u003cI\u003eAethina tumida\u003c/I\u003e (Coleoptera: Nitidulidae) Larvae and Pupae to Entomopathogenic Nematodes","created_at":"2021-11-03T06:59:50.852-07:00","url":"https://www.academia.edu/60906418/Susceptibility_of_I_Aethina_tumida_I_Coleoptera_Nitidulidae_Larvae_and_Pupae_to_Entomopathogenic_Nematodes?f_ri=43363","dom_id":"work_60906418","summary":"In this study, we evaluated the potential use of entomopathogenic nematodes as a control for the beetle Aethina tumida Murray (Coleoptera: Nitidulidae). In particular, we conducted 1) four screening bioassays to determine nematode (seven species, 10 total strains tested) and application level effects on A. tumida larvae and pupae, 2) a generational persistence bioassay to determine whether single inoculations with nematodes would control multiple generations of A. tumida larvae in treated soil, and 3) a Þeld bioassay to determine whether the nematodes would remain efÞcacious in the Þeld. In the screening bioassays, nematode efÞcacy varied signiÞcantly by tested nematode and the infective juvenile (IJ) level at which they were applied. Although nematode virulence was moderate in screening bioassays 1Ð3 (0 Ð 68% A. tumida mortality), A. tumida mortality approached higher levels in screening bioassay 4 (nearly 100% after 39 d) that suggest suitable applicability of some of the test nematodes as Þeld controls for A. tumida. In the generational persistence bioassay, Steinernema riobrave Cabanillas, Poinar \u0026 Raulston 7-12 strain and Heterorhabditis indica Poinar, Karunaka \u0026 David provided adequate A. tumida control for 19 wk after a single soil inoculation (76 Ð94% mortality in A. tumida pupae). In the Þeld bioassay, the same two nematode species also showed high virulence toward pupating A. tumida (88 Ð100%) mortality. Our data suggest that nematode use may be an integral component of an integrated pest management scheme aimed at reducing A. tumida populations in bee colonies to tolerable levels.","downloadable_attachments":[{"id":74145998,"asset_id":60906418,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37662099,"first_name":"Keith","last_name":"Delaplane","domain_name":"independent","page_name":"KeithDelaplane","display_name":"Keith Delaplane","profile_url":"https://independent.academia.edu/KeithDelaplane?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=43363","nofollow":true},{"id":23516,"name":"Integrated Pest Management","url":"https://www.academia.edu/Documents/in/Integrated_Pest_Management?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":52873,"name":"Virulence","url":"https://www.academia.edu/Documents/in/Virulence?f_ri=43363","nofollow":true},{"id":64753,"name":"Apis mellifera","url":"https://www.academia.edu/Documents/in/Apis_mellifera?f_ri=43363"},{"id":126465,"name":"Efficacy","url":"https://www.academia.edu/Documents/in/Efficacy?f_ri=43363"},{"id":413804,"name":"Inoculation","url":"https://www.academia.edu/Documents/in/Inoculation?f_ri=43363"},{"id":442493,"name":"Larva","url":"https://www.academia.edu/Documents/in/Larva?f_ri=43363"},{"id":508463,"name":"Larvae","url":"https://www.academia.edu/Documents/in/Larvae?f_ri=43363"},{"id":523097,"name":"Economic Entomology","url":"https://www.academia.edu/Documents/in/Economic_Entomology?f_ri=43363"},{"id":604764,"name":"Nymph","url":"https://www.academia.edu/Documents/in/Nymph?f_ri=43363"},{"id":689743,"name":"Bioassays","url":"https://www.academia.edu/Documents/in/Bioassays?f_ri=43363"},{"id":843856,"name":"Ecological Applications","url":"https://www.academia.edu/Documents/in/Ecological_Applications?f_ri=43363"},{"id":1149350,"name":"Entomopathogenic Nematode","url":"https://www.academia.edu/Documents/in/Entomopathogenic_Nematode?f_ri=43363"},{"id":1374584,"name":"Pupae","url":"https://www.academia.edu/Documents/in/Pupae?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_35522344 coauthored" data-work_id="35522344" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/35522344/Design_of_oseltamivir_analogs_inhibiting_neuraminidase_of_avian_influenza_virus_H5N1">Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neuraminidase is an important target for design of antiviral agents in the prophylaxis and treatment of avian influenza virus infections. We have shown the applicability of computer-assisted combinatorial techniques in the design,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_35522344" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neuraminidase is an important target for design of antiviral agents in the prophylaxis and treatment of avian influenza virus infections. We have shown the applicability of computer-assisted combinatorial techniques in the design, focusing and in silico screening of a virtual library of analogs of oseltamivir (Tamiflu) with the goal to find potent inhibitors of influenza A neuraminidase N1 that fill the cavity found adjacent to the active site. Crystal structure of oseltamivir-N1 complex was used in the structure-based focusing and virtual screening of the designed library. A target-specific Piecewise Linear Potential type 1 scoring function fitted for a training set of 14 carbocyclic inhibitors and validated for three other inhibitors was used to select virtual hits with predicted inhibitory activities in the subnanomolar range. The results of this computational study are useful as a rational guide for synthetic and medicinal chemists who are developing new drugs against the avian influenza virus H5N1.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/35522344" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ef3d75ba0780d3e339be2b1c43b6f08d" rel="nofollow" data-download="{"attachment_id":55387545,"asset_id":35522344,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/55387545/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="73249480" href="https://independent.academia.edu/VladimirFrecer">Vladimir Frecer</a><script data-card-contents-for-user="73249480" type="text/json">{"id":73249480,"first_name":"Vladimir","last_name":"Frecer","domain_name":"independent","page_name":"VladimirFrecer","display_name":"Vladimir Frecer","profile_url":"https://independent.academia.edu/VladimirFrecer?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-35522344">+1</span><div class="hidden js-additional-users-35522344"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/SMiertus">S. Miertus</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-35522344'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-35522344').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_35522344 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="35522344"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 35522344, container: ".js-paper-rank-work_35522344", }); });</script></li><li class="js-percentile-work_35522344 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 35522344; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_35522344"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_35522344 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="35522344"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 35522344; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=35522344]").text(description); $(".js-view-count-work_35522344").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_35522344").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="35522344"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">27</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="988" rel="nofollow" href="https://www.academia.edu/Documents/in/Design">Design</a>, <script data-card-contents-for-ri="988" type="text/json">{"id":988,"name":"Design","url":"https://www.academia.edu/Documents/in/Design?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6947" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a>, <script data-card-contents-for-ri="6947" type="text/json">{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12981" rel="nofollow" href="https://www.academia.edu/Documents/in/Enzyme_Inhibitors">Enzyme Inhibitors</a>, <script data-card-contents-for-ri="12981" type="text/json">{"id":12981,"name":"Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Enzyme_Inhibitors?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=35522344]'), work: {"id":35522344,"title":"Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1","created_at":"2017-12-27T15:24:57.386-08:00","url":"https://www.academia.edu/35522344/Design_of_oseltamivir_analogs_inhibiting_neuraminidase_of_avian_influenza_virus_H5N1?f_ri=43363","dom_id":"work_35522344","summary":"Neuraminidase is an important target for design of antiviral agents in the prophylaxis and treatment of avian influenza virus infections. We have shown the applicability of computer-assisted combinatorial techniques in the design, focusing and in silico screening of a virtual library of analogs of oseltamivir (Tamiflu) with the goal to find potent inhibitors of influenza A neuraminidase N1 that fill the cavity found adjacent to the active site. Crystal structure of oseltamivir-N1 complex was used in the structure-based focusing and virtual screening of the designed library. A target-specific Piecewise Linear Potential type 1 scoring function fitted for a training set of 14 carbocyclic inhibitors and validated for three other inhibitors was used to select virtual hits with predicted inhibitory activities in the subnanomolar range. The results of this computational study are useful as a rational guide for synthetic and medicinal chemists who are developing new drugs against the avian influenza virus H5N1.","downloadable_attachments":[{"id":55387545,"asset_id":35522344,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":73249480,"first_name":"Vladimir","last_name":"Frecer","domain_name":"independent","page_name":"VladimirFrecer","display_name":"Vladimir Frecer","profile_url":"https://independent.academia.edu/VladimirFrecer?f_ri=43363","photo":"/images/s65_no_pic.png"},{"id":36761347,"first_name":"S.","last_name":"Miertus","domain_name":"independent","page_name":"SMiertus","display_name":"S. Miertus","profile_url":"https://independent.academia.edu/SMiertus?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":988,"name":"Design","url":"https://www.academia.edu/Documents/in/Design?f_ri=43363","nofollow":true},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology?f_ri=43363","nofollow":true},{"id":12981,"name":"Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Enzyme_Inhibitors?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":50630,"name":"Crystal structure","url":"https://www.academia.edu/Documents/in/Crystal_structure?f_ri=43363"},{"id":57518,"name":"Conception","url":"https://www.academia.edu/Documents/in/Conception?f_ri=43363"},{"id":70037,"name":"Virtual screening","url":"https://www.academia.edu/Documents/in/Virtual_screening?f_ri=43363"},{"id":76677,"name":"influenza A","url":"https://www.academia.edu/Documents/in/influenza_A?f_ri=43363"},{"id":82145,"name":"Virus","url":"https://www.academia.edu/Documents/in/Virus?f_ri=43363"},{"id":83205,"name":"Avian Influenza","url":"https://www.academia.edu/Documents/in/Avian_Influenza?f_ri=43363"},{"id":100696,"name":"Combinatorial Chemistry","url":"https://www.academia.edu/Documents/in/Combinatorial_Chemistry?f_ri=43363"},{"id":119547,"name":"Oseltamivir","url":"https://www.academia.edu/Documents/in/Oseltamivir?f_ri=43363"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design?f_ri=43363"},{"id":132593,"name":"Piecewise Linear","url":"https://www.academia.edu/Documents/in/Piecewise_Linear?f_ri=43363"},{"id":172024,"name":"Analog","url":"https://www.academia.edu/Documents/in/Analog?f_ri=43363"},{"id":212097,"name":"Library Design","url":"https://www.academia.edu/Documents/in/Library_Design?f_ri=43363"},{"id":234622,"name":"Neuraminidase","url":"https://www.academia.edu/Documents/in/Neuraminidase?f_ri=43363"},{"id":354019,"name":"Active site","url":"https://www.academia.edu/Documents/in/Active_site?f_ri=43363"},{"id":709730,"name":"Analog Computation","url":"https://www.academia.edu/Documents/in/Analog_Computation?f_ri=43363"},{"id":713662,"name":"Virtual Library","url":"https://www.academia.edu/Documents/in/Virtual_Library?f_ri=43363"},{"id":792401,"name":"Antiviral","url":"https://www.academia.edu/Documents/in/Antiviral?f_ri=43363"},{"id":816379,"name":"Virus infection","url":"https://www.academia.edu/Documents/in/Virus_infection?f_ri=43363"},{"id":865697,"name":"In Silico","url":"https://www.academia.edu/Documents/in/In_Silico?f_ri=43363"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship?f_ri=43363"},{"id":1359009,"name":"Score Function","url":"https://www.academia.edu/Documents/in/Score_Function?f_ri=43363"},{"id":1431633,"name":"Chemical Structure","url":"https://www.academia.edu/Documents/in/Chemical_Structure?f_ri=43363"},{"id":2570247,"name":"antiviral agent","url":"https://www.academia.edu/Documents/in/antiviral_agent?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_32081777" data-work_id="32081777" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/32081777/Changing_Profile_of_Retinopathy_of_Prematurity">Changing Profile of Retinopathy of Prematurity</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Fifty-eight cases of CT scan-proven intracranial space occupying lesions (ICSOL) in children were biopsied. Tuberculoma of brain turned out to be a major consideration comprising 10.34 per cent, second only to astrocytomas which comprised... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_32081777" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Fifty-eight cases of CT scan-proven intracranial space occupying lesions (ICSOL) in children were biopsied. Tuberculoma of brain turned out to be a major consideration comprising 10.34 per cent, second only to astrocytomas which comprised 32.75 per cent of ICSOL. There were 13 non-neoplastic lesions, of which tuberculoma constituted 46.1 per cent. The need for awareness of this common entity in developing countries is discussed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32081777" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0d5e0ec56ade8256f3fd457eccc8f90e" rel="nofollow" data-download="{"attachment_id":52335705,"asset_id":32081777,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52335705/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="62040687" href="https://sysu.academia.edu/RajvardhanAzad">Rajvardhan Azad</a><script data-card-contents-for-user="62040687" type="text/json">{"id":62040687,"first_name":"Rajvardhan","last_name":"Azad","domain_name":"sysu","page_name":"RajvardhanAzad","display_name":"Rajvardhan Azad","profile_url":"https://sysu.academia.edu/RajvardhanAzad?f_ri=43363","photo":"https://0.academia-photos.com/62040687/19892092/19703741/s65_rajvardhan.azad.jpeg"}</script></span></span></li><li class="js-paper-rank-work_32081777 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="32081777"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 32081777, container: ".js-paper-rank-work_32081777", }); 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Tuberculoma of brain turned out to be a major consideration comprising 10.34 per cent, second only to astrocytomas which comprised 32.75 per cent of ICSOL. There were 13 non-neoplastic lesions, of which tuberculoma constituted 46.1 per cent. The need for awareness of this common entity in developing countries is discussed.","downloadable_attachments":[{"id":52335705,"asset_id":32081777,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":62040687,"first_name":"Rajvardhan","last_name":"Azad","domain_name":"sysu","page_name":"RajvardhanAzad","display_name":"Rajvardhan Azad","profile_url":"https://sysu.academia.edu/RajvardhanAzad?f_ri=43363","photo":"https://0.academia-photos.com/62040687/19892092/19703741/s65_rajvardhan.azad.jpeg"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=43363","nofollow":true},{"id":2065,"name":"Research Methodology","url":"https://www.academia.edu/Documents/in/Research_Methodology?f_ri=43363","nofollow":true},{"id":4559,"name":"Reproduction","url":"https://www.academia.edu/Documents/in/Reproduction?f_ri=43363","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=43363","nofollow":true},{"id":9815,"name":"Developing Countries","url":"https://www.academia.edu/Documents/in/Developing_Countries?f_ri=43363"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=43363"},{"id":14406,"name":"Health","url":"https://www.academia.edu/Documents/in/Health?f_ri=43363"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=43363"},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":43838,"name":"India","url":"https://www.academia.edu/Documents/in/India?f_ri=43363"},{"id":64336,"name":"Population","url":"https://www.academia.edu/Documents/in/Population?f_ri=43363"},{"id":81988,"name":"Comparative studies","url":"https://www.academia.edu/Documents/in/Comparative_studies?f_ri=43363"},{"id":96446,"name":"Measurement","url":"https://www.academia.edu/Documents/in/Measurement?f_ri=43363"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals?f_ri=43363"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=43363"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=43363"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=43363"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=43363"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=43363"},{"id":555414,"name":"Retinopathy of prematurity","url":"https://www.academia.edu/Documents/in/Retinopathy_of_prematurity?f_ri=43363"},{"id":608948,"name":"Tropical","url":"https://www.academia.edu/Documents/in/Tropical?f_ri=43363"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=43363"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1929089" data-work_id="1929089" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1929089/Differences_in_Predictors_of_Cervical_and_Breast_Cancer_Screening_by_Screening_Need_in_Uninsured_Latina_Women">Differences in Predictors of Cervical and Breast Cancer Screening by Screening Need in Uninsured Latina Women</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">BACKGROUND. Latina women experience higher mortality for cervical cancer and lower 5-year survival for breast cancer than non-Latina White women. Adherence with screening recommendations can increase chances of survival, yet the factors... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1929089" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">BACKGROUND. Latina women experience higher mortality for cervical cancer and lower 5-year survival for breast cancer than non-Latina White women. Adherence with screening recommendations can increase chances of survival, yet the factors that influence screening behaviors in uninsured women are not well documented.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1929089" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3bc91b74d739a4703952e4cac03bbcc6" rel="nofollow" data-download="{"attachment_id":50815967,"asset_id":1929089,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50815967/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2485532" href="https://independent.academia.edu/FacBukie">Fac Bukie</a><script data-card-contents-for-user="2485532" type="text/json">{"id":2485532,"first_name":"Fac","last_name":"Bukie","domain_name":"independent","page_name":"FacBukie","display_name":"Fac Bukie","profile_url":"https://independent.academia.edu/FacBukie?f_ri=43363","photo":"https://0.academia-photos.com/2485532/776985/965498/s65_fac.bukie.jpg"}</script></span></span></li><li class="js-paper-rank-work_1929089 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1929089"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1929089, container: ".js-paper-rank-work_1929089", }); });</script></li><li class="js-percentile-work_1929089 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 1929089; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_1929089"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_1929089 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="1929089"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 1929089; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=1929089]").text(description); $(".js-view-count-work_1929089").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1929089").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1929089"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" rel="nofollow" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7428" rel="nofollow" href="https://www.academia.edu/Documents/in/Health_Education">Health Education</a>, <script data-card-contents-for-ri="7428" type="text/json">{"id":7428,"name":"Health Education","url":"https://www.academia.edu/Documents/in/Health_Education?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26879" rel="nofollow" href="https://www.academia.edu/Documents/in/Social_Class">Social Class</a><script data-card-contents-for-ri="26879" type="text/json">{"id":26879,"name":"Social Class","url":"https://www.academia.edu/Documents/in/Social_Class?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1929089]'), work: {"id":1929089,"title":"Differences in Predictors of Cervical and Breast Cancer Screening by Screening Need in Uninsured Latina Women","created_at":"2012-09-11T21:08:03.377-07:00","url":"https://www.academia.edu/1929089/Differences_in_Predictors_of_Cervical_and_Breast_Cancer_Screening_by_Screening_Need_in_Uninsured_Latina_Women?f_ri=43363","dom_id":"work_1929089","summary":"BACKGROUND. Latina women experience higher mortality for cervical cancer and lower 5-year survival for breast cancer than non-Latina White women. Adherence with screening recommendations can increase chances of survival, yet the factors that influence screening behaviors in uninsured women are not well documented.","downloadable_attachments":[{"id":50815967,"asset_id":1929089,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":2485532,"first_name":"Fac","last_name":"Bukie","domain_name":"independent","page_name":"FacBukie","display_name":"Fac Bukie","profile_url":"https://independent.academia.edu/FacBukie?f_ri=43363","photo":"https://0.academia-photos.com/2485532/776985/965498/s65_fac.bukie.jpg"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=43363","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=43363","nofollow":true},{"id":7428,"name":"Health Education","url":"https://www.academia.edu/Documents/in/Health_Education?f_ri=43363","nofollow":true},{"id":26879,"name":"Social Class","url":"https://www.academia.edu/Documents/in/Social_Class?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=43363"},{"id":209590,"name":"Mammography","url":"https://www.academia.edu/Documents/in/Mammography?f_ri=43363"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=43363"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=43363"},{"id":369177,"name":"Breast Cancer Screening","url":"https://www.academia.edu/Documents/in/Breast_Cancer_Screening?f_ri=43363"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=43363"},{"id":546421,"name":"Educational Status","url":"https://www.academia.edu/Documents/in/Educational_Status?f_ri=43363"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population?f_ri=43363"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=43363"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10928767" data-work_id="10928767" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10928767/Synthesis_antimicrobial_and_anti_inflammatory_activities_of_novel_2_1_adamantyl_5_substituted_1_3_4_oxadiazoles_and_2_1_adamantylamino_5_substituted_1_3_4_thiadiazoles">Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in pyridine yielded the corresponding N-acyl adamantane-1-carbohydrazide derivatives 3a–j, which were cyclized to the corresponding... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10928767" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in pyridine yielded the corresponding N-acyl adamantane-1-carbohydrazide derivatives 3a–j, which were cyclized to the corresponding 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles 4a–jvia heating with phosphorus oxychloride. Treatment of 1-adamantylisothiocyanate with some carboxylic acid hydrazides in ethanol yielded the corresponding 1-acyl-4-(1-adamantyl)-3-thiosemicarbazides 7a–g, which were cyclized to the corresponding 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazole derivatives 8a–g. Compounds 4a–j, 7a–g, and 8a–g were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Several derivatives produced good or moderate activities particularly against the tested Gram-positive bacteria Bacillus subtilis. Meanwhile, compounds 4i and 8g displayed marked antifungal activity against C. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. The oxadiazole derivatives 4c, 4g, 4i and 4j produced good dose-dependent anti-inflammatory activity.New compounds with the above structures were synthesized and tested for antimicrobial and anti-inflammatory activity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10928767" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9a9c6a7a387be471191205b7668b6243" rel="nofollow" data-download="{"attachment_id":47017766,"asset_id":10928767,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47017766/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26503104" href="https://independent.academia.edu/NasserElBrollosy">Nasser El-Brollosy</a><script data-card-contents-for-user="26503104" type="text/json">{"id":26503104,"first_name":"Nasser","last_name":"El-Brollosy","domain_name":"independent","page_name":"NasserElBrollosy","display_name":"Nasser El-Brollosy","profile_url":"https://independent.academia.edu/NasserElBrollosy?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_10928767 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10928767"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10928767, container: ".js-paper-rank-work_10928767", }); 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$(".js-view-count[data-work-id=10928767]").text(description); $(".js-view-count-work_10928767").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_10928767").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="10928767"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">27</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="428" rel="nofollow" href="https://www.academia.edu/Documents/in/Algorithms">Algorithms</a>, <script data-card-contents-for-ri="428" type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="531" rel="nofollow" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="5769" rel="nofollow" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="17272" rel="nofollow" href="https://www.academia.edu/Documents/in/Fungi">Fungi</a><script data-card-contents-for-ri="17272" type="text/json">{"id":17272,"name":"Fungi","url":"https://www.academia.edu/Documents/in/Fungi?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10928767]'), work: {"id":10928767,"title":"Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles","created_at":"2015-02-19T05:48:58.050-08:00","url":"https://www.academia.edu/10928767/Synthesis_antimicrobial_and_anti_inflammatory_activities_of_novel_2_1_adamantyl_5_substituted_1_3_4_oxadiazoles_and_2_1_adamantylamino_5_substituted_1_3_4_thiadiazoles?f_ri=43363","dom_id":"work_10928767","summary":"Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in pyridine yielded the corresponding N-acyl adamantane-1-carbohydrazide derivatives 3a–j, which were cyclized to the corresponding 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles 4a–jvia heating with phosphorus oxychloride. Treatment of 1-adamantylisothiocyanate with some carboxylic acid hydrazides in ethanol yielded the corresponding 1-acyl-4-(1-adamantyl)-3-thiosemicarbazides 7a–g, which were cyclized to the corresponding 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazole derivatives 8a–g. Compounds 4a–j, 7a–g, and 8a–g were tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Several derivatives produced good or moderate activities particularly against the tested Gram-positive bacteria Bacillus subtilis. Meanwhile, compounds 4i and 8g displayed marked antifungal activity against C. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. The oxadiazole derivatives 4c, 4g, 4i and 4j produced good dose-dependent anti-inflammatory activity.New compounds with the above structures were synthesized and tested for antimicrobial and anti-inflammatory activity.","downloadable_attachments":[{"id":47017766,"asset_id":10928767,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26503104,"first_name":"Nasser","last_name":"El-Brollosy","domain_name":"independent","page_name":"NasserElBrollosy","display_name":"Nasser El-Brollosy","profile_url":"https://independent.academia.edu/NasserElBrollosy?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=43363","nofollow":true},{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=43363","nofollow":true},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=43363","nofollow":true},{"id":17272,"name":"Fungi","url":"https://www.academia.edu/Documents/in/Fungi?f_ri=43363","nofollow":true},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":55241,"name":"Synthetic Organic Chemistry","url":"https://www.academia.edu/Documents/in/Synthetic_Organic_Chemistry?f_ri=43363"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria?f_ri=43363"},{"id":131573,"name":"Candida albicans","url":"https://www.academia.edu/Documents/in/Candida_albicans?f_ri=43363"},{"id":204350,"name":"Anti-inflammatory agents","url":"https://www.academia.edu/Documents/in/Anti-inflammatory_agents?f_ri=43363"},{"id":237568,"name":"Gram Positive Bacteria","url":"https://www.academia.edu/Documents/in/Gram_Positive_Bacteria?f_ri=43363"},{"id":328449,"name":"Molecules","url":"https://www.academia.edu/Documents/in/Molecules?f_ri=43363"},{"id":335965,"name":"Gram-negative bacteria","url":"https://www.academia.edu/Documents/in/Gram-negative_bacteria?f_ri=43363"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents?f_ri=43363"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=43363"},{"id":382481,"name":"Edema","url":"https://www.academia.edu/Documents/in/Edema?f_ri=43363"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat?f_ri=43363"},{"id":552209,"name":"Antifungal Agents","url":"https://www.academia.edu/Documents/in/Antifungal_Agents?f_ri=43363"},{"id":561014,"name":"Microbial Sensitivity Tests","url":"https://www.academia.edu/Documents/in/Microbial_Sensitivity_Tests?f_ri=43363"},{"id":568887,"name":"Carrageenan","url":"https://www.academia.edu/Documents/in/Carrageenan?f_ri=43363"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity?f_ri=43363"},{"id":801411,"name":"Triazoles","url":"https://www.academia.edu/Documents/in/Triazoles?f_ri=43363"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship?f_ri=43363"},{"id":1152821,"name":"Chemical Synthesis","url":"https://www.academia.edu/Documents/in/Chemical_Synthesis?f_ri=43363"},{"id":1190805,"name":"Adamantane","url":"https://www.academia.edu/Documents/in/Adamantane?f_ri=43363"},{"id":1308525,"name":"Candida Tropicalis","url":"https://www.academia.edu/Documents/in/Candida_Tropicalis?f_ri=43363"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25831398" data-work_id="25831398" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25831398/A_new_polymeric_adsorbent_for_screening_and_pre_concentration_of_organotin_compounds_in_sediments_and_seawater_samples">A new polymeric adsorbent for screening and pre-concentration of organotin compounds in sediments and seawater samples</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A new adsorbent based on the imprinting technique with high retention capacity and pre-concentration factor has been synthesized and tested for retention of inorganic and organotin compounds wtributyltinchloride (TBT),... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25831398" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A new adsorbent based on the imprinting technique with high retention capacity and pre-concentration factor has been synthesized and tested for retention of inorganic and organotin compounds wtributyltinchloride (TBT), dibutyltindichloride (DBT), monobutylytintrichloride (MBT) and triphenyltinchoride (TPhT)x. The polymerization has been carried out in the presence of TBT, the target organotin compound of this work. These compounds can be quantitatively retained on this adsorbent over a wide pH range and after elution these compounds are determined by graphite furnace atomic absorption spectrometry (GFAAS). Only organotin compounds are eluted from the adsorbent with 0.1 M hydrochloric acid (HCl) in methanol (MeOH) solution whereas inorganic tin is eluted later on with a suitable complexing agent such as citric acid. Linearity is obtained in the concentration range 0.1-4 ng (5-200 mg l ) for each organotin compound with a correlation coefficient not less than 0.994 and relative y1 standard deviation -5% even for complex samples such as sediments and seawater samples. The detection limit has been found to be 30 ng l . Various parameters related to determination, pre-concentration and GFAAS conditions have been optimized. The y1 screening method proposed has been applied to the determination of organotin in natural sediments and seawater samples. The recovery is between 82 and 90% for TBT, DBT and TPhT and 50-55% for MBT in the case of sediment samples, while it is 97-103% for all the organotin compounds in seawater samples. The method has been conveniently validated using a standard sediment reference material. ᮊ</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25831398" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c374ae614aa2db9d8988214709d50af1" rel="nofollow" data-download="{"attachment_id":46197501,"asset_id":25831398,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46197501/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49609749" href="https://ucm.academia.edu/RiansaresMunozOlivas">Riansares Muñoz-Olivas</a><script data-card-contents-for-user="49609749" type="text/json">{"id":49609749,"first_name":"Riansares","last_name":"Muñoz-Olivas","domain_name":"ucm","page_name":"RiansaresMunozOlivas","display_name":"Riansares Muñoz-Olivas","profile_url":"https://ucm.academia.edu/RiansaresMunozOlivas?f_ri=43363","photo":"https://0.academia-photos.com/49609749/34458640/30278320/s65_riansares.mun_oz-olivas.jpg"}</script></span></span></li><li class="js-paper-rank-work_25831398 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25831398"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25831398, container: ".js-paper-rank-work_25831398", }); 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$(".js-view-count[data-work-id=25831398]").text(description); $(".js-view-count-work_25831398").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25831398").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25831398"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="118582" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_sciences">Physical sciences</a>, <script data-card-contents-for-ri="118582" type="text/json">{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="155340" rel="nofollow" href="https://www.academia.edu/Documents/in/Sediments">Sediments</a>, <script data-card-contents-for-ri="155340" type="text/json">{"id":155340,"name":"Sediments","url":"https://www.academia.edu/Documents/in/Sediments?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="184467" rel="nofollow" href="https://www.academia.edu/Documents/in/Seawater">Seawater</a><script data-card-contents-for-ri="184467" type="text/json">{"id":184467,"name":"Seawater","url":"https://www.academia.edu/Documents/in/Seawater?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25831398]'), work: {"id":25831398,"title":"A new polymeric adsorbent for screening and pre-concentration of organotin compounds in sediments and seawater samples","created_at":"2016-06-03T06:04:39.727-07:00","url":"https://www.academia.edu/25831398/A_new_polymeric_adsorbent_for_screening_and_pre_concentration_of_organotin_compounds_in_sediments_and_seawater_samples?f_ri=43363","dom_id":"work_25831398","summary":"A new adsorbent based on the imprinting technique with high retention capacity and pre-concentration factor has been synthesized and tested for retention of inorganic and organotin compounds wtributyltinchloride (TBT), dibutyltindichloride (DBT), monobutylytintrichloride (MBT) and triphenyltinchoride (TPhT)x. The polymerization has been carried out in the presence of TBT, the target organotin compound of this work. These compounds can be quantitatively retained on this adsorbent over a wide pH range and after elution these compounds are determined by graphite furnace atomic absorption spectrometry (GFAAS). Only organotin compounds are eluted from the adsorbent with 0.1 M hydrochloric acid (HCl) in methanol (MeOH) solution whereas inorganic tin is eluted later on with a suitable complexing agent such as citric acid. Linearity is obtained in the concentration range 0.1-4 ng (5-200 mg l ) for each organotin compound with a correlation coefficient not less than 0.994 and relative y1 standard deviation -5% even for complex samples such as sediments and seawater samples. The detection limit has been found to be 30 ng l . Various parameters related to determination, pre-concentration and GFAAS conditions have been optimized. The y1 screening method proposed has been applied to the determination of organotin in natural sediments and seawater samples. The recovery is between 82 and 90% for TBT, DBT and TPhT and 50-55% for MBT in the case of sediment samples, while it is 97-103% for all the organotin compounds in seawater samples. The method has been conveniently validated using a standard sediment reference material. ᮊ","downloadable_attachments":[{"id":46197501,"asset_id":25831398,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":49609749,"first_name":"Riansares","last_name":"Muñoz-Olivas","domain_name":"ucm","page_name":"RiansaresMunozOlivas","display_name":"Riansares Muñoz-Olivas","profile_url":"https://ucm.academia.edu/RiansaresMunozOlivas?f_ri=43363","photo":"https://0.academia-photos.com/49609749/34458640/30278320/s65_riansares.mun_oz-olivas.jpg"}],"research_interests":[{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences?f_ri=43363","nofollow":true},{"id":155340,"name":"Sediments","url":"https://www.academia.edu/Documents/in/Sediments?f_ri=43363","nofollow":true},{"id":184467,"name":"Seawater","url":"https://www.academia.edu/Documents/in/Seawater?f_ri=43363","nofollow":true},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=43363"},{"id":528315,"name":"STRESS CONCENTRATION FACTOR","url":"https://www.academia.edu/Documents/in/STRESS_CONCENTRATION_FACTOR?f_ri=43363"},{"id":611814,"name":"Correlation coefficient","url":"https://www.academia.edu/Documents/in/Correlation_coefficient?f_ri=43363"},{"id":977996,"name":"Citric Acid","url":"https://www.academia.edu/Documents/in/Citric_Acid?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_69848878" data-work_id="69848878" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/69848878/Small_Groups_Big_Gains_Efficacy_of_a_Tier_2_Phonological_Awareness_Intervention_with_Preschoolers_with_Early_Literacy_Deficits">Small Groups, Big Gains: Efficacy of a Tier 2 Phonological Awareness Intervention with Preschoolers with Early Literacy Deficits</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The purpose of the present study was to evaluate the efficacy of a phonological awareness (PA) intervention, designed for Tier 2 instruction in a Response to Intervention (RTI) model, delivered to small groups of preschoolers. A multiple... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69848878" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The purpose of the present study was to evaluate the efficacy of a phonological awareness (PA) intervention, designed for Tier 2 instruction in a Response to Intervention (RTI) model, delivered to small groups of preschoolers. A multiple baseline design across participants was used to evaluate the efficacy of the intervention on low-income preschool children&#39;s PA skills. A trained interventionist delivered small group sessions three to four days a week and ensured children received frequent opportunities to respond and contingent feedback. Participants received 28 to 36 lessons that lasted about 10 minutes each and focused on PA and alphabet knowledge. Initiation of intervention was staggered across three triads and seven children completed the study. The intervention produced consistent gains on weekly progress monitoring assessments of the primary outcome measure for first sound identification (First Sound Fluency). Most children also demonstrated gains on other measures of PA...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69848878" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5c7ae141a3585621bd597a99e1f949c8" rel="nofollow" data-download="{"attachment_id":79789467,"asset_id":69848878,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79789467/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="88569586" href="https://independent.academia.edu/TrinaSpencer">Trina Spencer</a><script data-card-contents-for-user="88569586" type="text/json">{"id":88569586,"first_name":"Trina","last_name":"Spencer","domain_name":"independent","page_name":"TrinaSpencer","display_name":"Trina Spencer","profile_url":"https://independent.academia.edu/TrinaSpencer?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_69848878 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69848878"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69848878, container: ".js-paper-rank-work_69848878", }); });</script></li><li class="js-percentile-work_69848878 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69848878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_69848878"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_69848878 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="69848878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69848878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69848878]").text(description); $(".js-view-count-work_69848878").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_69848878").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="69848878"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="858" rel="nofollow" href="https://www.academia.edu/Documents/in/Literacy">Literacy</a>, <script data-card-contents-for-ri="858" type="text/json">{"id":858,"name":"Literacy","url":"https://www.academia.edu/Documents/in/Literacy?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2139" rel="nofollow" href="https://www.academia.edu/Documents/in/Phonetics">Phonetics</a>, <script data-card-contents-for-ri="2139" type="text/json">{"id":2139,"name":"Phonetics","url":"https://www.academia.edu/Documents/in/Phonetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2808" rel="nofollow" href="https://www.academia.edu/Documents/in/Poverty">Poverty</a><script data-card-contents-for-ri="2808" type="text/json">{"id":2808,"name":"Poverty","url":"https://www.academia.edu/Documents/in/Poverty?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=69848878]'), work: {"id":69848878,"title":"Small Groups, Big Gains: Efficacy of a Tier 2 Phonological Awareness Intervention with Preschoolers with Early Literacy Deficits","created_at":"2022-01-28T20:42:11.309-08:00","url":"https://www.academia.edu/69848878/Small_Groups_Big_Gains_Efficacy_of_a_Tier_2_Phonological_Awareness_Intervention_with_Preschoolers_with_Early_Literacy_Deficits?f_ri=43363","dom_id":"work_69848878","summary":"The purpose of the present study was to evaluate the efficacy of a phonological awareness (PA) intervention, designed for Tier 2 instruction in a Response to Intervention (RTI) model, delivered to small groups of preschoolers. A multiple baseline design across participants was used to evaluate the efficacy of the intervention on low-income preschool children\u0026#39;s PA skills. A trained interventionist delivered small group sessions three to four days a week and ensured children received frequent opportunities to respond and contingent feedback. Participants received 28 to 36 lessons that lasted about 10 minutes each and focused on PA and alphabet knowledge. Initiation of intervention was staggered across three triads and seven children completed the study. The intervention produced consistent gains on weekly progress monitoring assessments of the primary outcome measure for first sound identification (First Sound Fluency). Most children also demonstrated gains on other measures of PA...","downloadable_attachments":[{"id":79789467,"asset_id":69848878,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":88569586,"first_name":"Trina","last_name":"Spencer","domain_name":"independent","page_name":"TrinaSpencer","display_name":"Trina Spencer","profile_url":"https://independent.academia.edu/TrinaSpencer?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=43363","nofollow":true},{"id":858,"name":"Literacy","url":"https://www.academia.edu/Documents/in/Literacy?f_ri=43363","nofollow":true},{"id":2139,"name":"Phonetics","url":"https://www.academia.edu/Documents/in/Phonetics?f_ri=43363","nofollow":true},{"id":2808,"name":"Poverty","url":"https://www.academia.edu/Documents/in/Poverty?f_ri=43363","nofollow":true},{"id":15674,"name":"Linguistics","url":"https://www.academia.edu/Documents/in/Linguistics?f_ri=43363"},{"id":19988,"name":"Group Processes","url":"https://www.academia.edu/Documents/in/Group_Processes?f_ri=43363"},{"id":25052,"name":"Dyslexia","url":"https://www.academia.edu/Documents/in/Dyslexia?f_ri=43363"},{"id":37753,"name":"Teaching","url":"https://www.academia.edu/Documents/in/Teaching?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":44057,"name":"Curriculum","url":"https://www.academia.edu/Documents/in/Curriculum?f_ri=43363"},{"id":197351,"name":"Awareness","url":"https://www.academia.edu/Documents/in/Awareness?f_ri=43363"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=43363"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=43363"},{"id":3549212,"name":"Language Development Disorders","url":"https://www.academia.edu/Documents/in/Language_Development_Disorders?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_58416005" data-work_id="58416005" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58416005/Nurses_as_information_providers_facilitating_understanding_and_communication_of_statistical_information">Nurses as information providers: facilitating understanding and communication of statistical information</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Nurses are increasingly being called upon to be the conveyers of important statistical information to patients. This trend is particularly evident in the domains of genetics and cancer screening. These new roles, however, demand new... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_58416005" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Nurses are increasingly being called upon to be the conveyers of important statistical information to patients. This trend is particularly evident in the domains of genetics and cancer screening. These new roles, however, demand new competencies, such as the ability to solve statistical problems, and the skill to communicate the answers effectively, as effective communication is an important ingredient in shared decision making. Genetic testing, perhaps more than other medical domains, relies heavily on the use of statistics. Being able to convey statistical information effectively is vital. In this paper, we illustrate the problems health care professionals have had in tackling and communicating statistical information. We introduce the natural frequencies method of solving Bayesian inference problems and review empirical evidence that shows the superiority of this format. Being able to transform probabilities into natural frequencies facilitates correct Bayesian inferences. It is argued that the conventional approach to educating nurses in Bayesian problem solving should be reconsidered and their statistical curriculum should be supplemented with instruction in using the natural frequency format.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58416005" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="665e4d8be20511c81d69ef1e011c2f98" rel="nofollow" data-download="{"attachment_id":72837625,"asset_id":58416005,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72837625/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="134497812" href="https://independent.academia.edu/Hanoch">Yaniv Hanoch</a><script data-card-contents-for-user="134497812" type="text/json">{"id":134497812,"first_name":"Yaniv","last_name":"Hanoch","domain_name":"independent","page_name":"Hanoch","display_name":"Yaniv Hanoch","profile_url":"https://independent.academia.edu/Hanoch?f_ri=43363","photo":"https://0.academia-photos.com/134497812/41676300/33696369/s65_yaniv.hanoch.jpg"}</script></span></span></li><li class="js-paper-rank-work_58416005 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58416005"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58416005, container: ".js-paper-rank-work_58416005", }); });</script></li><li class="js-percentile-work_58416005 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 58416005; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_58416005"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_58416005 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="58416005"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 58416005; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=58416005]").text(description); $(".js-view-count-work_58416005").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_58416005").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="58416005"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="588" rel="nofollow" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1681" rel="nofollow" href="https://www.academia.edu/Documents/in/Decision_Making">Decision Making</a>, <script data-card-contents-for-ri="1681" type="text/json">{"id":1681,"name":"Decision Making","url":"https://www.academia.edu/Documents/in/Decision_Making?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4441" rel="nofollow" href="https://www.academia.edu/Documents/in/Health_Care">Health Care</a><script data-card-contents-for-ri="4441" type="text/json">{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=58416005]'), work: {"id":58416005,"title":"Nurses as information providers: facilitating understanding and communication of statistical information","created_at":"2021-10-16T08:07:57.145-07:00","url":"https://www.academia.edu/58416005/Nurses_as_information_providers_facilitating_understanding_and_communication_of_statistical_information?f_ri=43363","dom_id":"work_58416005","summary":"Nurses are increasingly being called upon to be the conveyers of important statistical information to patients. This trend is particularly evident in the domains of genetics and cancer screening. These new roles, however, demand new competencies, such as the ability to solve statistical problems, and the skill to communicate the answers effectively, as effective communication is an important ingredient in shared decision making. Genetic testing, perhaps more than other medical domains, relies heavily on the use of statistics. Being able to convey statistical information effectively is vital. In this paper, we illustrate the problems health care professionals have had in tackling and communicating statistical information. We introduce the natural frequencies method of solving Bayesian inference problems and review empirical evidence that shows the superiority of this format. Being able to transform probabilities into natural frequencies facilitates correct Bayesian inferences. It is argued that the conventional approach to educating nurses in Bayesian problem solving should be reconsidered and their statistical curriculum should be supplemented with instruction in using the natural frequency format.","downloadable_attachments":[{"id":72837625,"asset_id":58416005,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":134497812,"first_name":"Yaniv","last_name":"Hanoch","domain_name":"independent","page_name":"Hanoch","display_name":"Yaniv Hanoch","profile_url":"https://independent.academia.edu/Hanoch?f_ri=43363","photo":"https://0.academia-photos.com/134497812/41676300/33696369/s65_yaniv.hanoch.jpg"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=43363","nofollow":true},{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=43363","nofollow":true},{"id":1681,"name":"Decision Making","url":"https://www.academia.edu/Documents/in/Decision_Making?f_ri=43363","nofollow":true},{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care?f_ri=43363","nofollow":true},{"id":19870,"name":"Research","url":"https://www.academia.edu/Documents/in/Research?f_ri=43363"},{"id":24144,"name":"Shared decision making","url":"https://www.academia.edu/Documents/in/Shared_decision_making?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":47904,"name":"Genetic counseling","url":"https://www.academia.edu/Documents/in/Genetic_counseling?f_ri=43363"},{"id":49419,"name":"Problem Solving","url":"https://www.academia.edu/Documents/in/Problem_Solving?f_ri=43363"},{"id":51529,"name":"Bayesian Inference","url":"https://www.academia.edu/Documents/in/Bayesian_Inference?f_ri=43363"},{"id":73153,"name":"Genetic Testing","url":"https://www.academia.edu/Documents/in/Genetic_Testing?f_ri=43363"},{"id":83130,"name":"genetic Counselling","url":"https://www.academia.edu/Documents/in/genetic_Counselling?f_ri=43363"},{"id":111630,"name":"Cancer Screening","url":"https://www.academia.edu/Documents/in/Cancer_Screening?f_ri=43363"},{"id":146633,"name":"Natural Frequency","url":"https://www.academia.edu/Documents/in/Natural_Frequency?f_ri=43363"},{"id":256855,"name":"Probabilities","url":"https://www.academia.edu/Documents/in/Probabilities?f_ri=43363"},{"id":332827,"name":"Natural Frequencies","url":"https://www.academia.edu/Documents/in/Natural_Frequencies?f_ri=43363"},{"id":393134,"name":"Empirical evidence","url":"https://www.academia.edu/Documents/in/Empirical_evidence?f_ri=43363"},{"id":880279,"name":"Bayes Theorem","url":"https://www.academia.edu/Documents/in/Bayes_Theorem-1?f_ri=43363"},{"id":3693190,"name":"mass Screening","url":"https://www.academia.edu/Documents/in/mass_Screening?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_55255557" data-work_id="55255557" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/55255557/Ethical_legal_and_social_implications_ELSI_of_microdose_clinical_trials">Ethical, legal, and social implications (ELSI) of microdose clinical trials</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A "microdose clinical trial" (microdosing) is one kind of early phase exploratory clinical trial, administering the compound at doses estimated to have no pharmacological or toxicological effects, aimed at screening candidates for further... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_55255557" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A "microdose clinical trial" (microdosing) is one kind of early phase exploratory clinical trial, administering the compound at doses estimated to have no pharmacological or toxicological effects, aimed at screening candidates for further clinical development. This article's objective is to clarify the ethical, legal, and social implications (ELSI) of such an exploratory minimum-risk human trial. The definition and non-clinical study requirements for microdosing have been harmonized among the European Union (EU), United States (US), and Japan. Being conducted according to these regulations, microdosing seems to be ethically well justified in terms of respect for persons, beneficence, justice, human dignity, and animal welfare. Three big projects have been demonstrating the predictability of therapeutic dose pharmacokinetics from microdosing. The article offers suggestions as how microdosing can become a more useful and socially accepted strategy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55255557" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a6af4865969f6b8128e43dda7516038f" rel="nofollow" data-download="{"attachment_id":71212195,"asset_id":55255557,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71212195/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58880172" href="https://independent.academia.edu/chiekokurihara">chieko kurihara</a><script data-card-contents-for-user="58880172" type="text/json">{"id":58880172,"first_name":"chieko","last_name":"kurihara","domain_name":"independent","page_name":"chiekokurihara","display_name":"chieko kurihara","profile_url":"https://independent.academia.edu/chiekokurihara?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_55255557 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="55255557"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 55255557, container: ".js-paper-rank-work_55255557", }); });</script></li><li class="js-percentile-work_55255557 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55255557; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_55255557"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_55255557 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="55255557"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55255557; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55255557]").text(description); $(".js-view-count-work_55255557").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_55255557").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="55255557"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="814" rel="nofollow" href="https://www.academia.edu/Documents/in/Ethics">Ethics</a>, <script data-card-contents-for-ri="814" type="text/json">{"id":814,"name":"Ethics","url":"https://www.academia.edu/Documents/in/Ethics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4531" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10347" rel="nofollow" href="https://www.academia.edu/Documents/in/European_Union">European Union</a>, <script data-card-contents-for-ri="10347" type="text/json">{"id":10347,"name":"European Union","url":"https://www.academia.edu/Documents/in/European_Union?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12204" rel="nofollow" href="https://www.academia.edu/Documents/in/Animal_Welfare">Animal Welfare</a><script data-card-contents-for-ri="12204" type="text/json">{"id":12204,"name":"Animal Welfare","url":"https://www.academia.edu/Documents/in/Animal_Welfare?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=55255557]'), work: {"id":55255557,"title":"Ethical, legal, and social implications (ELSI) of microdose clinical trials","created_at":"2021-10-03T16:07:37.986-07:00","url":"https://www.academia.edu/55255557/Ethical_legal_and_social_implications_ELSI_of_microdose_clinical_trials?f_ri=43363","dom_id":"work_55255557","summary":"A \"microdose clinical trial\" (microdosing) is one kind of early phase exploratory clinical trial, administering the compound at doses estimated to have no pharmacological or toxicological effects, aimed at screening candidates for further clinical development. This article's objective is to clarify the ethical, legal, and social implications (ELSI) of such an exploratory minimum-risk human trial. The definition and non-clinical study requirements for microdosing have been harmonized among the European Union (EU), United States (US), and Japan. Being conducted according to these regulations, microdosing seems to be ethically well justified in terms of respect for persons, beneficence, justice, human dignity, and animal welfare. Three big projects have been demonstrating the predictability of therapeutic dose pharmacokinetics from microdosing. The article offers suggestions as how microdosing can become a more useful and socially accepted strategy.","downloadable_attachments":[{"id":71212195,"asset_id":55255557,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":58880172,"first_name":"chieko","last_name":"kurihara","domain_name":"independent","page_name":"chiekokurihara","display_name":"chieko kurihara","profile_url":"https://independent.academia.edu/chiekokurihara?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":814,"name":"Ethics","url":"https://www.academia.edu/Documents/in/Ethics?f_ri=43363","nofollow":true},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=43363","nofollow":true},{"id":10347,"name":"European Union","url":"https://www.academia.edu/Documents/in/European_Union?f_ri=43363","nofollow":true},{"id":12204,"name":"Animal Welfare","url":"https://www.academia.edu/Documents/in/Animal_Welfare?f_ri=43363","nofollow":true},{"id":13841,"name":"Drug development","url":"https://www.academia.edu/Documents/in/Drug_development?f_ri=43363"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=43363"},{"id":17158,"name":"Japan","url":"https://www.academia.edu/Documents/in/Japan?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=43363"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design?f_ri=43363"},{"id":387754,"name":"Social Acceptance","url":"https://www.academia.edu/Documents/in/Social_Acceptance?f_ri=43363"},{"id":466424,"name":"Internationality","url":"https://www.academia.edu/Documents/in/Internationality?f_ri=43363"},{"id":546356,"name":"Clinical Study","url":"https://www.academia.edu/Documents/in/Clinical_Study?f_ri=43363"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_41006765" data-work_id="41006765" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/41006765/The_chemical_and_environmental_property_space_of_REACH_chemicals">The chemical and environmental property space of REACH chemicals</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The European regulation on chemicals, REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), came into force on 1 June 2007. With pre-registration complete in 2008, data for these substances may provide an overview... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_41006765" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The European regulation on chemicals, REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), came into force on 1 June 2007. With pre-registration complete in 2008, data for these substances may provide an overview of the expected chemical space and its characteristics. In this paper, using various in silico computation tools, we evaluate 48 782 neutral organic compounds from the list to identify hazardous and safe compounds. Two different classification schemes (modified Verhaar and ECOSAR) identified between 17% and 25% of the compounds as expressing only baseline toxicity (narcosis). A smaller portion could be identified as reactive (19%) or specifically acting (2.7%), while the majority were non-assigned (61%). Overall environmental persistence, bioaccumulation and long-range transport potential were evaluated using structure-activity relationships and a multimedia fugacity-based model. A surprisingly high proportion of compounds (20%), mainly aromatic and halogenated, had a very high estimated persistence (>195 d). The proportion of compounds with a very high estimated bioconcentration or bioaccumulation factor (>5000) was substantially less (6.9%). Finally, a list was compiled of those compounds within the applicability domain of the models used, meeting both persistence and bioaccumulation criteria, and with a long-range transport potential comparable to PCB. This list of 68 potential persistent organic pollutants contained many well-known compounds (all halogenated), but notably also five fluorinated compounds that were not included in the EINECS inventory. This study demonstrates the usability of in silico tools for identification of potentially environmentally hazardous chemicals.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/41006765" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="620dba250521aac1d3c4d61733481f5d" rel="nofollow" data-download="{"attachment_id":61287854,"asset_id":41006765,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/61287854/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="136222413" href="https://independent.academia.edu/SarfrazIqbal2">Sarfraz Iqbal</a><script data-card-contents-for-user="136222413" type="text/json">{"id":136222413,"first_name":"Sarfraz","last_name":"Iqbal","domain_name":"independent","page_name":"SarfrazIqbal2","display_name":"Sarfraz Iqbal","profile_url":"https://independent.academia.edu/SarfrazIqbal2?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_41006765 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="41006765"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 41006765, container: ".js-paper-rank-work_41006765", }); 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$(".js-view-count[data-work-id=41006765]").text(description); $(".js-view-count-work_41006765").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_41006765").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="41006765"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1210" rel="nofollow" href="https://www.academia.edu/Documents/in/Informatics">Informatics</a>, <script data-card-contents-for-ri="1210" type="text/json">{"id":1210,"name":"Informatics","url":"https://www.academia.edu/Documents/in/Informatics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6305" rel="nofollow" href="https://www.academia.edu/Documents/in/Bioaccumulation">Bioaccumulation</a>, <script data-card-contents-for-ri="6305" type="text/json">{"id":6305,"name":"Bioaccumulation","url":"https://www.academia.edu/Documents/in/Bioaccumulation?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28235" rel="nofollow" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a>, <script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=41006765]'), work: {"id":41006765,"title":"The chemical and environmental property space of REACH chemicals","created_at":"2019-11-21T03:00:48.770-08:00","url":"https://www.academia.edu/41006765/The_chemical_and_environmental_property_space_of_REACH_chemicals?f_ri=43363","dom_id":"work_41006765","summary":"The European regulation on chemicals, REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), came into force on 1 June 2007. With pre-registration complete in 2008, data for these substances may provide an overview of the expected chemical space and its characteristics. In this paper, using various in silico computation tools, we evaluate 48 782 neutral organic compounds from the list to identify hazardous and safe compounds. Two different classification schemes (modified Verhaar and ECOSAR) identified between 17% and 25% of the compounds as expressing only baseline toxicity (narcosis). A smaller portion could be identified as reactive (19%) or specifically acting (2.7%), while the majority were non-assigned (61%). Overall environmental persistence, bioaccumulation and long-range transport potential were evaluated using structure-activity relationships and a multimedia fugacity-based model. A surprisingly high proportion of compounds (20%), mainly aromatic and halogenated, had a very high estimated persistence (\u003e195 d). The proportion of compounds with a very high estimated bioconcentration or bioaccumulation factor (\u003e5000) was substantially less (6.9%). Finally, a list was compiled of those compounds within the applicability domain of the models used, meeting both persistence and bioaccumulation criteria, and with a long-range transport potential comparable to PCB. This list of 68 potential persistent organic pollutants contained many well-known compounds (all halogenated), but notably also five fluorinated compounds that were not included in the EINECS inventory. This study demonstrates the usability of in silico tools for identification of potentially environmentally hazardous chemicals.","downloadable_attachments":[{"id":61287854,"asset_id":41006765,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":136222413,"first_name":"Sarfraz","last_name":"Iqbal","domain_name":"independent","page_name":"SarfrazIqbal2","display_name":"Sarfraz Iqbal","profile_url":"https://independent.academia.edu/SarfrazIqbal2?f_ri=43363","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1210,"name":"Informatics","url":"https://www.academia.edu/Documents/in/Informatics?f_ri=43363","nofollow":true},{"id":6305,"name":"Bioaccumulation","url":"https://www.academia.edu/Documents/in/Bioaccumulation?f_ri=43363","nofollow":true},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":49161,"name":"Safety","url":"https://www.academia.edu/Documents/in/Safety?f_ri=43363"},{"id":53338,"name":"Decision Trees","url":"https://www.academia.edu/Documents/in/Decision_Trees?f_ri=43363"},{"id":70018,"name":"QSAR","url":"https://www.academia.edu/Documents/in/QSAR?f_ri=43363"},{"id":75826,"name":"Europe","url":"https://www.academia.edu/Documents/in/Europe?f_ri=43363"},{"id":164747,"name":"Moa","url":"https://www.academia.edu/Documents/in/Moa?f_ri=43363"},{"id":168304,"name":"SAR","url":"https://www.academia.edu/Documents/in/SAR?f_ri=43363"},{"id":174775,"name":"Pca","url":"https://www.academia.edu/Documents/in/Pca?f_ri=43363"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=43363"},{"id":626774,"name":"CTD","url":"https://www.academia.edu/Documents/in/CTD?f_ri=43363"},{"id":736321,"name":"Environmental Pollutants","url":"https://www.academia.edu/Documents/in/Environmental_Pollutants?f_ri=43363"},{"id":967054,"name":"EINECS","url":"https://www.academia.edu/Documents/in/EINECS?f_ri=43363"},{"id":991655,"name":"Formal Social Control","url":"https://www.academia.edu/Documents/in/Formal_Social_Control?f_ri=43363"},{"id":1208706,"name":"Environment","url":"https://www.academia.edu/Documents/in/Environment?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_29318601" data-work_id="29318601" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/29318601/Screening_Diagnosis_and_Treatment_of_Glaucoma_in_Farsi_">Screening, Diagnosis & Treatment of Glaucoma (in Farsi)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">‫ﻧﺎﺑـﯿﻨﺎﯾﯽ‬ ‫دﻟﯿﻞ‬ ‫دوﻣﯿﻦ‬ ‫و‬ ‫ﭘﯿﺸﮕﯿﺮی«‬ ‫ﻗﺎﺑﻞ‬ ‫»ﻧﺎﺑﯿﻨﺎﯾﯽ‬ ‫ﻋﺎﻣﻞ‬ ‫ﺍوﻟﯿﻦ‬ ‫ﮔﻠﻮﮐﻮم،‬ ‫ﺑـﺮ-‬ ‫ﺍﺳـﺖ.‬ ‫ﺷـﺪه‬ ‫ﺑـﺮآورد‬ ‫درﺻﺪ‬ 2 ‫5/1ﺗﺎ‬ ‫دﻧﯿﺎ‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺷﯿﻮﻉ‬ ‫ﯽﺑﺎﺷﺪ.‬ ‫ﻣ‬ ‫ﺟﻬﺎن‬ ‫ﺳﺮﺍﺳﺮ‬ ‫در‬ ‫ﻣﯽ-‬ ‫ﺯﻧﺪﮔﯽ‬ ‫ﺟﻬﺎن‬ ‫در‬ ‫ﻧﺎﺑـﯿﻨﺎ‬... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_29318601" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">‫ﻧﺎﺑـﯿﻨﺎﯾﯽ‬ ‫دﻟﯿﻞ‬ ‫دوﻣﯿﻦ‬ ‫و‬ ‫ﭘﯿﺸﮕﯿﺮی«‬ ‫ﻗﺎﺑﻞ‬ ‫»ﻧﺎﺑﯿﻨﺎﯾﯽ‬ ‫ﻋﺎﻣﻞ‬ ‫ﺍوﻟﯿﻦ‬ ‫ﮔﻠﻮﮐﻮم،‬ ‫ﺑـﺮ-‬ ‫ﺍﺳـﺖ.‬ ‫ﺷـﺪه‬ ‫ﺑـﺮآورد‬ ‫درﺻﺪ‬ 2 ‫5/1ﺗﺎ‬ ‫دﻧﯿﺎ‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺷﯿﻮﻉ‬ ‫ﯽﺑﺎﺷﺪ.‬ ‫ﻣ‬ ‫ﺟﻬﺎن‬ ‫ﺳﺮﺍﺳﺮ‬ ‫در‬ ‫ﻣﯽ-‬ ‫ﺯﻧﺪﮔﯽ‬ ‫ﺟﻬﺎن‬ ‫در‬ ‫ﻧﺎﺑـﯿﻨﺎ‬ ‫ﻣﯿﻠﯿﻮن‬ ‫و‬ ‫ﺑـﯿﻨﺎ‬ ‫ﮐﻢ‬ ‫ﻣﯿﻠﯿﻮن‬ 161 ‫ﺣﺪود‬ ‫ﺟﻬﺎﻧﯽ‬ ‫آﻣﺎر‬ ‫ﺍﺳﺎس‬ 37 ‫ﺟﻬﺎﻧﯽ‬ ‫ﺑــﺎر‬ ‫ﯽدﻫﺪ.‬ ‫ﻣ‬ ‫ﺗﺸــﻜﯿﻞ‬ ‫رﺍ‬ ‫ﻧﺎﺑــﯿﻨﺎﯾﯽ‬ ‫ﺟﻬﺎﻧﯽ‬ ‫ﺑـﺎر‬ ‫درﺻﺪ‬ 12/3 ‫ﻋﺎﻣﻞ‬ ‫ﮔﻠﻮﮐﻮم‬ ‫و‬ ‫ﮐﻨﻨﺪ‬ ‫ﺑـﺎرﺯﺗﺮ‬ ‫ﺯﻧﺎن‬ ‫و‬ ‫ﻣﯿﺎﻧﺴـﺎل‬ ‫ﺍﻓﺮﺍد‬ ‫در‬ ‫ﺗﻮﺳﻌﻪ،‬ ‫درﺣﺎل‬ ‫ﮐﺸﻮرﻫﺎی‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺑﻪ‬ ‫ﻣﻨﺘﺴﺐ‬ ‫ﻧﺎﺑﯿﻨﺎﯾﯽ‬ ‫ﺗﺎ‬ ‫ﺳـﺎل‬ ‫ﺗﺎ‬ ‫و‬ ‫ﻧﻔﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ ،2010 ‫ﺳﺎل‬ ‫ﺗﺎ‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺟﻬﺎﻧﯽ‬ ‫رﻗﻢ‬ ‫ﺑﺎﺷﺪ.‬ ‫ﻣﯽ‬ 79/6 2020 60/5 8/4 ‫ﮔﻠﻮﮐﻮم‬ ‫ﺍﺯ‬ ‫ﻧﺎﺷـﯽ‬ ‫ﻃﺮﻓﻪ‬ ‫ﯾﻚ‬ ‫ﻧﺎﺑـﯿﻨﺎﯾﯽ‬ ‫ﺷـﯿﻮﻉ‬ ‫ﻫﻤﭽﻨﯿﻦ‬ ‫ﺍﺳـﺖ.‬ ‫ﺷـﺪه‬ ‫آورد‬ ‫ﺑـﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ ‫ﺍﺳﺖ.‬ ‫ﺷﺪه‬ ‫ﺑﯿﻨﯽ‬ ‫ﭘﯿﺶ‬ ‫ﺳﺎل‬ ‫ﺗﺎ‬ ‫ﻧﻔﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ ‫و‬ 2010 ‫ﺳﺎل‬ ‫ﺗﺎ‬ ‫ﻧﻔﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ 2020 11 ‫درﺻﺪ‬ 1/44 ‫ﮔﻠﻮﮐﻮم‬ ‫ﺷـــﯿﻮﻉ‬ ‫ﻣﯿﺰﺍن‬ ‫ﺗﻬﺮﺍن،‬ ‫ﺷــﻬﺮ‬ ‫ﻣﺨﺘﻠﻒ‬ ‫ﻣﻨﺎﻃﻖ‬ ‫ﻪﺍی‬ ‫ﺧﻮﺷــ‬ ‫ﻣﻄﺎﻟﻌﻪ‬ ‫در‬ ‫در‬ ‫و‬ ‫درﺻﺪ‬ ‫ﺳـﺎل،‬ ‫ﺗﺎ‬ ‫ﺳـﻨﯿﻦ‬ ‫در‬ ‫ﮐﺸﻮر‬ ‫در‬ ‫ﺷﯿﻮﻉ‬ ‫ﻣﯿﺰﺍن‬ ‫ﺍﯾﻦ‬ ‫ﺍﺳﺖ.‬ ‫ﺷﺪه‬ ‫ﮔﺰﺍرش‬ 0/5 49 40 ‫ﺍﺳﺖ.‬ ‫ﺷﺪه‬ ‫ﮔﺰﺍرش‬ ‫درﺻﺪ‬ 5 ‫ﺳﺎل،‬ ‫ﺍﺯ‬ ‫ﺑﯿﺶ‬ ‫ﺳﻨﯿﻦ‬ 80 ‫روﺯ-‬ ‫ﭼﺎﻟﺶ‬ ‫و‬ ‫ﯽﺑﺎﺷـﺪ‬ ‫ﻣ‬ ‫ﺍﻓﺰﺍﯾﺶ‬ ‫ﺑـﻪ‬ ‫رو‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﭘﺰﺷﻜﯽ‬ ‫ﻫﺎی‬ ‫ﻣﺮﺍﻗﺒﺖ‬ ‫ﺍﺯ‬ ‫ﺣﺎﺻﻞ‬ ‫ﺍﻗﺘﺼﺎدی‬ ‫ﺑﺎر‬ ‫ﻧﺘﺎﯾﺞ‬ ‫ﺑﺎﺷـﺪ.‬ ‫ﻣﯽ‬ ‫ﺟﻬﺎن‬ ‫ﺳـﻄﺢ‬ ‫در‬ ‫ﭘﺰﺷـﻜﯽ‬ ‫ﻫﺎی‬ ‫ﻣﺮﺍﻗﺒـﺖ‬ ‫ﺗﻮﺯﯾﻊ‬ ‫ﻧﺤـﻮه‬ ‫ﺑﻪ‬ ‫ﺗﻮﺟﻪ‬ ‫دﯾﮕﺮ‬ ‫ﺍﻓﺰون‬ ‫ﻫﺰﯾﻨﻪ‬ ‫ﮐﻪ‬ ‫ﺍﺳـﺖ‬ ‫آن‬ ‫ﺍﺯ‬ ‫ﺣـﺎﮐﯽ‬ ‫ﺍﻧﮕﻠﯿﺲ‬ ‫و‬ ‫آﻟﻤﺎن‬ ‫ﻓﺮﺍﻧﺴـﻪ،‬ ‫ﺍﯾﺘﺎﻟﯿﺎ،‬ ‫ﺍروﭘﺎﯾﯽ‬ ‫ﮐﺸﻮر‬ 4 ‫در‬ ‫ﻣﻄﺎﻟﻌﻪ‬ ‫ﻫﺰﺍر‬ 3 ‫ﺳـﯿﺎه‬ ‫آب‬ ‫ﺑﻪ‬ ‫ﻣﺒﺘﻼ‬ ‫دﻻر،‬ ‫ﭼﺸﻤﯽ‬ ‫دﺍﺧﻞ‬ ‫ﻓﺸﺎر‬ ‫ﺍﻓﺰﺍﯾﺶ‬ ‫ﺑﻪ‬ ‫ﻣﺒﺘﻼ‬ ‫ﻓﺮد‬ ‫ﯾﻚ‬ ‫درﻣﺎن‬ 300 ‫ﺳﺎﻟﻤﻨﺪ‬ ‫ﺣـﺎل‬ ‫در‬ ‫ﺟﻤﻌﯿﺖ‬ ‫ﮐﻪ‬ ‫آﻧﺠﺎ‬ ‫ﺍﺯ‬ ‫ﺍﺳـﺖ.‬ ‫ﺳـﺎل‬ ‫در‬ ‫دﻻر‬ ‫ﻫﺰﺍر‬ 9 ‫درﻣﺎن‬ ‫ﺗﺤـﺖ‬ ‫ﺍﻓﺮﺍد‬ ‫و‬ ‫دﻻر‬ ‫ﮐﻪ‬ ‫ﺷـﻮد‬ ‫ﻣﯽ‬ ‫ﺶﺑـﯿﻨﯽ‬ ‫ﭘﯿ‬ ‫ﯽﺑﺎﺷـﺪ،‬ ‫ﻣ‬ ‫ﺍﻓﺰﺍﯾﺶ‬ ‫ﺣـﺎل‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﻫﺎی‬ ‫ﻣﺮﺍﻗﺒـﺖ‬ ‫ﻧﯿﺎﺯﻣﻨﺪ‬ ‫و‬ ‫ﺷﺪن‬ ‫ﺷﻮد.‬ ‫ﺍﻓﺰوده‬ ‫ﭘﯿﺶ‬ ‫ﺍﺯ‬ ‫ﺑﯿﺶ‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺍﺯ‬ ‫ﻧﺎﺷﯽ‬ ‫ﭘﺰﺷﻜﯽ‬ ‫ﻫﺎی‬ ‫ﻫﺰﯾﻨﻪ‬</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29318601" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="308f0108e2c5ac0ce26443993a7228a5" rel="nofollow" data-download="{"attachment_id":49759282,"asset_id":29318601,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="29318601"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a>, <script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="96572" rel="nofollow" href="https://www.academia.edu/Documents/in/Glaucoma">Glaucoma</a><script data-card-contents-for-ri="96572" type="text/json">{"id":96572,"name":"Glaucoma","url":"https://www.academia.edu/Documents/in/Glaucoma?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=29318601]'), work: {"id":29318601,"title":"Screening, Diagnosis \u0026 Treatment of Glaucoma (in Farsi)","created_at":"2016-10-21T01:28:56.666-07:00","url":"https://www.academia.edu/29318601/Screening_Diagnosis_and_Treatment_of_Glaucoma_in_Farsi_?f_ri=43363","dom_id":"work_29318601","summary":"‫ﻧﺎﺑـﯿﻨﺎﯾﯽ‬ ‫دﻟﯿﻞ‬ ‫دوﻣﯿﻦ‬ ‫و‬ ‫ﭘﯿﺸﮕﯿﺮی«‬ ‫ﻗﺎﺑﻞ‬ ‫»ﻧﺎﺑﯿﻨﺎﯾﯽ‬ ‫ﻋﺎﻣﻞ‬ ‫ﺍوﻟﯿﻦ‬ ‫ﮔﻠﻮﮐﻮم،‬ ‫ﺑـﺮ-‬ ‫ﺍﺳـﺖ.‬ ‫ﺷـﺪه‬ ‫ﺑـﺮآورد‬ ‫درﺻﺪ‬ 2 ‫5/1ﺗﺎ‬ ‫دﻧﯿﺎ‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺷﯿﻮﻉ‬ ‫ﯽﺑﺎﺷﺪ.‬ ‫ﻣ‬ ‫ﺟﻬﺎن‬ ‫ﺳﺮﺍﺳﺮ‬ ‫در‬ ‫ﻣﯽ-‬ ‫ﺯﻧﺪﮔﯽ‬ ‫ﺟﻬﺎن‬ ‫در‬ ‫ﻧﺎﺑـﯿﻨﺎ‬ ‫ﻣﯿﻠﯿﻮن‬ ‫و‬ ‫ﺑـﯿﻨﺎ‬ ‫ﮐﻢ‬ ‫ﻣﯿﻠﯿﻮن‬ 161 ‫ﺣﺪود‬ ‫ﺟﻬﺎﻧﯽ‬ ‫آﻣﺎر‬ ‫ﺍﺳﺎس‬ 37 ‫ﺟﻬﺎﻧﯽ‬ ‫ﺑــﺎر‬ ‫ﯽدﻫﺪ.‬ ‫ﻣ‬ ‫ﺗﺸــﻜﯿﻞ‬ ‫رﺍ‬ ‫ﻧﺎﺑــﯿﻨﺎﯾﯽ‬ ‫ﺟﻬﺎﻧﯽ‬ ‫ﺑـﺎر‬ ‫درﺻﺪ‬ 12/3 ‫ﻋﺎﻣﻞ‬ ‫ﮔﻠﻮﮐﻮم‬ ‫و‬ ‫ﮐﻨﻨﺪ‬ ‫ﺑـﺎرﺯﺗﺮ‬ ‫ﺯﻧﺎن‬ ‫و‬ ‫ﻣﯿﺎﻧﺴـﺎل‬ ‫ﺍﻓﺮﺍد‬ ‫در‬ ‫ﺗﻮﺳﻌﻪ،‬ ‫درﺣﺎل‬ ‫ﮐﺸﻮرﻫﺎی‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺑﻪ‬ ‫ﻣﻨﺘﺴﺐ‬ ‫ﻧﺎﺑﯿﻨﺎﯾﯽ‬ ‫ﺗﺎ‬ ‫ﺳـﺎل‬ ‫ﺗﺎ‬ ‫و‬ ‫ﻧﻔﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ ،2010 ‫ﺳﺎل‬ ‫ﺗﺎ‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺟﻬﺎﻧﯽ‬ ‫رﻗﻢ‬ ‫ﺑﺎﺷﺪ.‬ ‫ﻣﯽ‬ 79/6 2020 60/5 8/4 ‫ﮔﻠﻮﮐﻮم‬ ‫ﺍﺯ‬ ‫ﻧﺎﺷـﯽ‬ ‫ﻃﺮﻓﻪ‬ ‫ﯾﻚ‬ ‫ﻧﺎﺑـﯿﻨﺎﯾﯽ‬ ‫ﺷـﯿﻮﻉ‬ ‫ﻫﻤﭽﻨﯿﻦ‬ ‫ﺍﺳـﺖ.‬ ‫ﺷـﺪه‬ ‫آورد‬ ‫ﺑـﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ ‫ﺍﺳﺖ.‬ ‫ﺷﺪه‬ ‫ﺑﯿﻨﯽ‬ ‫ﭘﯿﺶ‬ ‫ﺳﺎل‬ ‫ﺗﺎ‬ ‫ﻧﻔﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ ‫و‬ 2010 ‫ﺳﺎل‬ ‫ﺗﺎ‬ ‫ﻧﻔﺮ‬ ‫ﻣﯿﻠﯿﻮن‬ 2020 11 ‫درﺻﺪ‬ 1/44 ‫ﮔﻠﻮﮐﻮم‬ ‫ﺷـــﯿﻮﻉ‬ ‫ﻣﯿﺰﺍن‬ ‫ﺗﻬﺮﺍن،‬ ‫ﺷــﻬﺮ‬ ‫ﻣﺨﺘﻠﻒ‬ ‫ﻣﻨﺎﻃﻖ‬ ‫ﻪﺍی‬ ‫ﺧﻮﺷــ‬ ‫ﻣﻄﺎﻟﻌﻪ‬ ‫در‬ ‫در‬ ‫و‬ ‫درﺻﺪ‬ ‫ﺳـﺎل،‬ ‫ﺗﺎ‬ ‫ﺳـﻨﯿﻦ‬ ‫در‬ ‫ﮐﺸﻮر‬ ‫در‬ ‫ﺷﯿﻮﻉ‬ ‫ﻣﯿﺰﺍن‬ ‫ﺍﯾﻦ‬ ‫ﺍﺳﺖ.‬ ‫ﺷﺪه‬ ‫ﮔﺰﺍرش‬ 0/5 49 40 ‫ﺍﺳﺖ.‬ ‫ﺷﺪه‬ ‫ﮔﺰﺍرش‬ ‫درﺻﺪ‬ 5 ‫ﺳﺎل،‬ ‫ﺍﺯ‬ ‫ﺑﯿﺶ‬ ‫ﺳﻨﯿﻦ‬ 80 ‫روﺯ-‬ ‫ﭼﺎﻟﺶ‬ ‫و‬ ‫ﯽﺑﺎﺷـﺪ‬ ‫ﻣ‬ ‫ﺍﻓﺰﺍﯾﺶ‬ ‫ﺑـﻪ‬ ‫رو‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﭘﺰﺷﻜﯽ‬ ‫ﻫﺎی‬ ‫ﻣﺮﺍﻗﺒﺖ‬ ‫ﺍﺯ‬ ‫ﺣﺎﺻﻞ‬ ‫ﺍﻗﺘﺼﺎدی‬ ‫ﺑﺎر‬ ‫ﻧﺘﺎﯾﺞ‬ ‫ﺑﺎﺷـﺪ.‬ ‫ﻣﯽ‬ ‫ﺟﻬﺎن‬ ‫ﺳـﻄﺢ‬ ‫در‬ ‫ﭘﺰﺷـﻜﯽ‬ ‫ﻫﺎی‬ ‫ﻣﺮﺍﻗﺒـﺖ‬ ‫ﺗﻮﺯﯾﻊ‬ ‫ﻧﺤـﻮه‬ ‫ﺑﻪ‬ ‫ﺗﻮﺟﻪ‬ ‫دﯾﮕﺮ‬ ‫ﺍﻓﺰون‬ ‫ﻫﺰﯾﻨﻪ‬ ‫ﮐﻪ‬ ‫ﺍﺳـﺖ‬ ‫آن‬ ‫ﺍﺯ‬ ‫ﺣـﺎﮐﯽ‬ ‫ﺍﻧﮕﻠﯿﺲ‬ ‫و‬ ‫آﻟﻤﺎن‬ ‫ﻓﺮﺍﻧﺴـﻪ،‬ ‫ﺍﯾﺘﺎﻟﯿﺎ،‬ ‫ﺍروﭘﺎﯾﯽ‬ ‫ﮐﺸﻮر‬ 4 ‫در‬ ‫ﻣﻄﺎﻟﻌﻪ‬ ‫ﻫﺰﺍر‬ 3 ‫ﺳـﯿﺎه‬ ‫آب‬ ‫ﺑﻪ‬ ‫ﻣﺒﺘﻼ‬ ‫دﻻر،‬ ‫ﭼﺸﻤﯽ‬ ‫دﺍﺧﻞ‬ ‫ﻓﺸﺎر‬ ‫ﺍﻓﺰﺍﯾﺶ‬ ‫ﺑﻪ‬ ‫ﻣﺒﺘﻼ‬ ‫ﻓﺮد‬ ‫ﯾﻚ‬ ‫درﻣﺎن‬ 300 ‫ﺳﺎﻟﻤﻨﺪ‬ ‫ﺣـﺎل‬ ‫در‬ ‫ﺟﻤﻌﯿﺖ‬ ‫ﮐﻪ‬ ‫آﻧﺠﺎ‬ ‫ﺍﺯ‬ ‫ﺍﺳـﺖ.‬ ‫ﺳـﺎل‬ ‫در‬ ‫دﻻر‬ ‫ﻫﺰﺍر‬ 9 ‫درﻣﺎن‬ ‫ﺗﺤـﺖ‬ ‫ﺍﻓﺮﺍد‬ ‫و‬ ‫دﻻر‬ ‫ﮐﻪ‬ ‫ﺷـﻮد‬ ‫ﻣﯽ‬ ‫ﺶﺑـﯿﻨﯽ‬ ‫ﭘﯿ‬ ‫ﯽﺑﺎﺷـﺪ،‬ ‫ﻣ‬ ‫ﺍﻓﺰﺍﯾﺶ‬ ‫ﺣـﺎل‬ ‫در‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﻫﺎی‬ ‫ﻣﺮﺍﻗﺒـﺖ‬ ‫ﻧﯿﺎﺯﻣﻨﺪ‬ ‫و‬ ‫ﺷﺪن‬ ‫ﺷﻮد.‬ ‫ﺍﻓﺰوده‬ ‫ﭘﯿﺶ‬ ‫ﺍﺯ‬ ‫ﺑﯿﺶ‬ ‫ﮔﻠﻮﮐﻮم‬ ‫ﺍﺯ‬ ‫ﻧﺎﺷﯽ‬ ‫ﭘﺰﺷﻜﯽ‬ ‫ﻫﺎی‬ ‫ﻫﺰﯾﻨﻪ‬","downloadable_attachments":[{"id":49759282,"asset_id":29318601,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8993797,"first_name":"Hanieh","last_name":"Delshad","domain_name":"tums","page_name":"HaniehDelshadAghdam","display_name":"Hanieh Delshad","profile_url":"https://tums.academia.edu/HaniehDelshadAghdam?f_ri=43363","photo":"https://0.academia-photos.com/8993797/2932802/13151505/s65_hanieh.delshad.jpg"}],"research_interests":[{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":96572,"name":"Glaucoma","url":"https://www.academia.edu/Documents/in/Glaucoma?f_ri=43363","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27019888" data-work_id="27019888" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27019888/Molecular_imprinting_based_separation_methods_for_selective_analysis_of_fluoroquinolones_in_soils">Molecular imprinting-based separation methods for selective analysis of fluoroquinolones in soils</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Molecularly imprinted polymers (MIPs) for fluoroquinolone antibiotics (FQs) have been synthesised in one single preparative step by precipitation polymerisation using ciprofloxacin (CIP) as template. Combinations of methacrylic acid (MAA)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27019888" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Molecularly imprinted polymers (MIPs) for fluoroquinolone antibiotics (FQs) have been synthesised in one single preparative step by precipitation polymerisation using ciprofloxacin (CIP) as template. Combinations of methacrylic acid (MAA) or 4-vinylpyridine (VP) as functional monomers, ethylene glycol dimethacrylate as crosslinker and dichloromethane, methanol, acetonitrile or toluene as porogens were tested. The experiments carried out by molecularly imprinted solid-phase extraction (MISPE) in cartridges did not allow to detect any imprint effect in the VP-based polymers whereas it was clearly observed in the MAA-based polymers. Among them, the MIP prepared in methanol using MAA as monomer showed the best performance and was chosen for further experiments. The ability of the selected MIP for the selective recognition of other widely used FQs (enoxacin, norfloxacin, danofloxacin and enrofloxacin) and quinolones (Qs) (cinoxacin, flumequine, nalidixic acid and oxolinic acid) was evaluated. The obtained results revealed the high selectivity of the obtained polymer, which was able to distinguish between FQs, that were recognised and retained onto the MIP cartridge, and Qs, which were washed out during loading and washing steps. The MIP was then packed into a stainless steel column (50 mm × 4.6 mm i.d.) and evaluated as chromatography column for screening of FQs in soil samples. The mobile phase composition, flow rate, and the elution profile were then optimised in order to improve peak shape without sacrifying imprinting factor. Finally, under optimised conditions, soil samples spiked with CIP or with a mixture of fluoroquinolones in concentration of 0.5 g g −1 were successfully analysed by the developed MIP-based procedures.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27019888" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="86814d6c26f2e5c1fd17162590d6fac5" rel="nofollow" data-download="{"attachment_id":47285254,"asset_id":27019888,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47285254/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11690063" href="https://uctemuco.academia.edu/AntonioEsteban">Antonio Esteban</a><script data-card-contents-for-user="11690063" type="text/json">{"id":11690063,"first_name":"Antonio","last_name":"Esteban","domain_name":"uctemuco","page_name":"AntonioEsteban","display_name":"Antonio Esteban","profile_url":"https://uctemuco.academia.edu/AntonioEsteban?f_ri=43363","photo":"https://0.academia-photos.com/11690063/3373052/3969163/s65_antonio.esteban.jpg"}</script></span></span></li><li class="js-paper-rank-work_27019888 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27019888"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27019888, container: ".js-paper-rank-work_27019888", }); 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Combinations of methacrylic acid (MAA) or 4-vinylpyridine (VP) as functional monomers, ethylene glycol dimethacrylate as crosslinker and dichloromethane, methanol, acetonitrile or toluene as porogens were tested. The experiments carried out by molecularly imprinted solid-phase extraction (MISPE) in cartridges did not allow to detect any imprint effect in the VP-based polymers whereas it was clearly observed in the MAA-based polymers. Among them, the MIP prepared in methanol using MAA as monomer showed the best performance and was chosen for further experiments. The ability of the selected MIP for the selective recognition of other widely used FQs (enoxacin, norfloxacin, danofloxacin and enrofloxacin) and quinolones (Qs) (cinoxacin, flumequine, nalidixic acid and oxolinic acid) was evaluated. The obtained results revealed the high selectivity of the obtained polymer, which was able to distinguish between FQs, that were recognised and retained onto the MIP cartridge, and Qs, which were washed out during loading and washing steps. The MIP was then packed into a stainless steel column (50 mm × 4.6 mm i.d.) and evaluated as chromatography column for screening of FQs in soil samples. The mobile phase composition, flow rate, and the elution profile were then optimised in order to improve peak shape without sacrifying imprinting factor. Finally, under optimised conditions, soil samples spiked with CIP or with a mixture of fluoroquinolones in concentration of 0.5 g g −1 were successfully analysed by the developed MIP-based procedures.","downloadable_attachments":[{"id":47285254,"asset_id":27019888,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":11690063,"first_name":"Antonio","last_name":"Esteban","domain_name":"uctemuco","page_name":"AntonioEsteban","display_name":"Antonio Esteban","profile_url":"https://uctemuco.academia.edu/AntonioEsteban?f_ri=43363","photo":"https://0.academia-photos.com/11690063/3373052/3969163/s65_antonio.esteban.jpg"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=43363","nofollow":true},{"id":923,"name":"Technology","url":"https://www.academia.edu/Documents/in/Technology?f_ri=43363","nofollow":true},{"id":15625,"name":"Molecular Imprinting","url":"https://www.academia.edu/Documents/in/Molecular_Imprinting?f_ri=43363","nofollow":true},{"id":21466,"name":"Polymers","url":"https://www.academia.edu/Documents/in/Polymers?f_ri=43363","nofollow":true},{"id":39752,"name":"Adsorption","url":"https://www.academia.edu/Documents/in/Adsorption?f_ri=43363"},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363"},{"id":83426,"name":"Solid Phase Extraction","url":"https://www.academia.edu/Documents/in/Solid_Phase_Extraction?f_ri=43363"},{"id":112334,"name":"Methanol","url":"https://www.academia.edu/Documents/in/Methanol?f_ri=43363"},{"id":128789,"name":"Stainless Steel","url":"https://www.academia.edu/Documents/in/Stainless_Steel?f_ri=43363"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography?f_ri=43363"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=43363"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents?f_ri=43363"},{"id":490260,"name":"Pyridines","url":"https://www.academia.edu/Documents/in/Pyridines?f_ri=43363"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=43363"},{"id":782913,"name":"Ciprofloxacin","url":"https://www.academia.edu/Documents/in/Ciprofloxacin?f_ri=43363"},{"id":845844,"name":"Polymethyl Methacrylates","url":"https://www.academia.edu/Documents/in/Polymethyl_Methacrylates?f_ri=43363"},{"id":898062,"name":"Flow Rate","url":"https://www.academia.edu/Documents/in/Flow_Rate?f_ri=43363"},{"id":963891,"name":"Toluene","url":"https://www.academia.edu/Documents/in/Toluene?f_ri=43363"},{"id":1365470,"name":"Soil Pollutants","url":"https://www.academia.edu/Documents/in/Soil_Pollutants?f_ri=43363"},{"id":1552428,"name":"Fluoroquinolones","url":"https://www.academia.edu/Documents/in/Fluoroquinolones?f_ri=43363"},{"id":1650162,"name":"Ethylene Glycol","url":"https://www.academia.edu/Documents/in/Ethylene_Glycol?f_ri=43363"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure?f_ri=43363"},{"id":1819024,"name":"Molecularly Imprinted Polymers","url":"https://www.academia.edu/Documents/in/Molecularly_Imprinted_Polymers?f_ri=43363"},{"id":2061307,"name":"Nalidixic acid","url":"https://www.academia.edu/Documents/in/Nalidixic_acid?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11158795" data-work_id="11158795" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11158795/A_nonlinear_HIV_AIDS_model_with_contact_tracing">A nonlinear HIV/AIDS model with contact tracing</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A nonlinear mathematical model is proposed and analyzed to study the effect of contact tracing on reducing the spread of HIV/AIDS in a homogeneous population with constant immigration of susceptibles. In modeling the dynamics, the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11158795" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A nonlinear mathematical model is proposed and analyzed to study the effect of contact tracing on reducing the spread of HIV/AIDS in a homogeneous population with constant immigration of susceptibles. In modeling the dynamics, the population is divided into four subclasses of HIV negatives but susceptibles, HIV positives or infectives that do not know they are infected, HIV positives that know they are infected and that of AIDS patients. Susceptibles are assumed to become infected via sexual contacts with (both types of) infectives and all infectives move with constant rates to develop AIDS. The model is analyzed using the stability theory of differential equations and numerical simulation. The model analysis shows that contact tracing may be of immense help in reducing the spread of AIDS epidemic in a population. It is also found that the endemicity of infection is reduced when infectives after becoming aware of their infection do not take part in sexual interaction. (A. Tripathi).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11158795" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f1cd02588ab59be3dfddb8390bf197fa" rel="nofollow" data-download="{"attachment_id":46851290,"asset_id":11158795,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46851290/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26943511" href="https://independent.academia.edu/AgrajTripathi">Agraj Tripathi</a><script data-card-contents-for-user="26943511" type="text/json">{"id":26943511,"first_name":"Agraj","last_name":"Tripathi","domain_name":"independent","page_name":"AgrajTripathi","display_name":"Agraj Tripathi","profile_url":"https://independent.academia.edu/AgrajTripathi?f_ri=43363","photo":"https://0.academia-photos.com/26943511/10312802/11507996/s65_agraj.tripathi.jpg"}</script></span></span></li><li class="js-paper-rank-work_11158795 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11158795"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11158795, container: ".js-paper-rank-work_11158795", }); 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$(".js-view-count[data-work-id=11158795]").text(description); $(".js-view-count-work_11158795").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11158795").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11158795"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="305" rel="nofollow" href="https://www.academia.edu/Documents/in/Applied_Mathematics">Applied Mathematics</a>, <script data-card-contents-for-ri="305" type="text/json">{"id":305,"name":"Applied Mathematics","url":"https://www.academia.edu/Documents/in/Applied_Mathematics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11417" rel="nofollow" href="https://www.academia.edu/Documents/in/Population_Dynamics">Population Dynamics</a>, <script data-card-contents-for-ri="11417" type="text/json">{"id":11417,"name":"Population Dynamics","url":"https://www.academia.edu/Documents/in/Population_Dynamics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12022" rel="nofollow" href="https://www.academia.edu/Documents/in/Numerical_Analysis">Numerical Analysis</a>, <script data-card-contents-for-ri="12022" type="text/json">{"id":12022,"name":"Numerical Analysis","url":"https://www.academia.edu/Documents/in/Numerical_Analysis?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="43363" rel="nofollow" href="https://www.academia.edu/Documents/in/Screening">Screening</a><script data-card-contents-for-ri="43363" type="text/json">{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11158795]'), work: {"id":11158795,"title":"A nonlinear HIV/AIDS model with contact tracing","created_at":"2015-02-28T02:09:14.879-08:00","url":"https://www.academia.edu/11158795/A_nonlinear_HIV_AIDS_model_with_contact_tracing?f_ri=43363","dom_id":"work_11158795","summary":"A nonlinear mathematical model is proposed and analyzed to study the effect of contact tracing on reducing the spread of HIV/AIDS in a homogeneous population with constant immigration of susceptibles. In modeling the dynamics, the population is divided into four subclasses of HIV negatives but susceptibles, HIV positives or infectives that do not know they are infected, HIV positives that know they are infected and that of AIDS patients. Susceptibles are assumed to become infected via sexual contacts with (both types of) infectives and all infectives move with constant rates to develop AIDS. The model is analyzed using the stability theory of differential equations and numerical simulation. The model analysis shows that contact tracing may be of immense help in reducing the spread of AIDS epidemic in a population. It is also found that the endemicity of infection is reduced when infectives after becoming aware of their infection do not take part in sexual interaction. (A. Tripathi).","downloadable_attachments":[{"id":46851290,"asset_id":11158795,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26943511,"first_name":"Agraj","last_name":"Tripathi","domain_name":"independent","page_name":"AgrajTripathi","display_name":"Agraj Tripathi","profile_url":"https://independent.academia.edu/AgrajTripathi?f_ri=43363","photo":"https://0.academia-photos.com/26943511/10312802/11507996/s65_agraj.tripathi.jpg"}],"research_interests":[{"id":305,"name":"Applied Mathematics","url":"https://www.academia.edu/Documents/in/Applied_Mathematics?f_ri=43363","nofollow":true},{"id":11417,"name":"Population Dynamics","url":"https://www.academia.edu/Documents/in/Population_Dynamics?f_ri=43363","nofollow":true},{"id":12022,"name":"Numerical Analysis","url":"https://www.academia.edu/Documents/in/Numerical_Analysis?f_ri=43363","nofollow":true},{"id":43363,"name":"Screening","url":"https://www.academia.edu/Documents/in/Screening?f_ri=43363","nofollow":true},{"id":60658,"name":"Numerical Simulation","url":"https://www.academia.edu/Documents/in/Numerical_Simulation?f_ri=43363"},{"id":136751,"name":"Stability Analysis","url":"https://www.academia.edu/Documents/in/Stability_Analysis?f_ri=43363"},{"id":191443,"name":"Stability Theory","url":"https://www.academia.edu/Documents/in/Stability_Theory?f_ri=43363"},{"id":291387,"name":"Mathematical Model","url":"https://www.academia.edu/Documents/in/Mathematical_Model?f_ri=43363"},{"id":543191,"name":"Reproduction number","url":"https://www.academia.edu/Documents/in/Reproduction_number?f_ri=43363"},{"id":556845,"name":"Numerical Analysis and Computational Mathematics","url":"https://www.academia.edu/Documents/in/Numerical_Analysis_and_Computational_Mathematics?f_ri=43363"},{"id":584470,"name":"Model Analysis","url":"https://www.academia.edu/Documents/in/Model_Analysis?f_ri=43363"},{"id":606723,"name":"Numerical Stability","url":"https://www.academia.edu/Documents/in/Numerical_Stability?f_ri=43363"},{"id":765146,"name":"Differential equation","url":"https://www.academia.edu/Documents/in/Differential_equation?f_ri=43363"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_9311441" data-work_id="9311441" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9311441/Screening_for_Adolescent_Depression_A_Comparison_of_Depression_Scales">Screening for Adolescent Depression: A Comparison of Depression Scales</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The abilit y of two depression scales, the Center for Epidemiologic Studies Depression Scale (CES-D) and the BeckDepression Inventory (BOI), to identify cases of DSM-Il/-R majordepression and dysthymia wasinvestigated in a large,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_9311441" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The abilit y of two depression scales, the Center for Epidemiologic Studies Depression Scale (CES-D) and the BeckDepression Inventory (BOI), to identify cases of DSM-Il/-R majordepression and dysthymia wasinvestigated in a large, community sample of highschool students. Receiver operating characteristics analyses indicated thatdifferent caseness criteria should be usedfor boys and girls for boththe CES-D and the BDI. Internal consistency-reliability and sensitivity and specificity for detecting current episodes of current depression and dysthymiawereadequate andcomparable to those found with adult samples , but boththeCES-D and the BDIgenerated many false positives. Multiple screening using the " serial" strategy increased positive predictive powersubstantially for both the CES-D and the BDI, whereas using the "parallel" strategy had very little effect on the efficacy of thetwo screeners. The results indicate that neither the BOI nor theCES-D should be usedby themselves as methods for case ascertainment in eitherepidemiological or experimental studies, although the BOIdoes function somewhat better than the CES-D as a screener.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9311441" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="85e08d4f0436ad25b8ba8eab07b4b762" rel="nofollow" data-download="{"attachment_id":47826422,"asset_id":9311441,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47826422/download_file?st=MTc0MDM0Mjc3OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="21483431" href="https://independent.academia.edu/RobertRobert27">Robert Robert</a><script data-card-contents-for-user="21483431" type="text/json">{"id":21483431,"first_name":"Robert","last_name":"Robert","domain_name":"independent","page_name":"RobertRobert27","display_name":"Robert Robert","profile_url":"https://independent.academia.edu/RobertRobert27?f_ri=43363","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9311441 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9311441"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9311441, container: ".js-paper-rank-work_9311441", }); 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$(".js-view-count[data-work-id=9311441]").text(description); $(".js-view-count-work_9311441").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_9311441").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="9311441"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1085" rel="nofollow" href="https://www.academia.edu/Documents/in/Epidemiology">Epidemiology</a>, <script data-card-contents-for-ri="1085" type="text/json">{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2599" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychometrics">Psychometrics</a>, <script data-card-contents-for-ri="2599" type="text/json">{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3217" rel="nofollow" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=43363","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=43363","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=9311441]'), work: {"id":9311441,"title":"Screening for Adolescent Depression: A Comparison of Depression Scales","created_at":"2014-11-14T16:31:46.532-08:00","url":"https://www.academia.edu/9311441/Screening_for_Adolescent_Depression_A_Comparison_of_Depression_Scales?f_ri=43363","dom_id":"work_9311441","summary":"The abilit y of two depression scales, the Center for Epidemiologic Studies Depression Scale (CES-D) and the BeckDepression Inventory (BOI), to identify cases of DSM-Il/-R majordepression and dysthymia wasinvestigated in a large, community sample of highschool students. Receiver operating characteristics analyses indicated thatdifferent caseness criteria should be usedfor boys and girls for boththe CES-D and the BDI. Internal consistency-reliability and sensitivity and specificity for detecting current episodes of current depression and dysthymiawereadequate andcomparable to those found with adult samples , but boththeCES-D and the BDIgenerated many false positives. Multiple screening using the \" serial\" strategy increased positive predictive powersubstantially for both the CES-D and the BDI, whereas using the \"parallel\" strategy had very little effect on the efficacy of thetwo screeners. The results indicate that neither the BOI nor theCES-D should be usedby themselves as methods for case ascertainment in eitherepidemiological or experimental studies, although the BOIdoes function somewhat better than the CES-D as a screener.","downloadable_attachments":[{"id":47826422,"asset_id":9311441,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":21483431,"first_name":"Robert","last_name":"Robert","domain_name":"independent","page_name":"RobertRobert27","display_name":"Robert 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