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Leuven</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/baldimarina"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/baldimarina">marina baldi</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uniwa.academia.edu/ThaliaBei"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uniwa.academia.edu/ThaliaBei">Thalia Bei</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of West Attica / Πανεπιστήμιο Δυτικής Αττικής</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/RaquelRodrigues11"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/RaquelRodrigues11">Raquel Rodrigues</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ua-birmingham.academia.edu/LMessiaen"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ua-birmingham.academia.edu/LMessiaen">Ludwine Messiaen</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Alabama at Birmingham</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="51785298" href="https://www.academia.edu/Documents/in/Ecological_Genomics"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/PremaKolachana","location":"/PremaKolachana","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/PremaKolachana","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" 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data-work-id="27598202"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598202/Genomic_Alterations_in_Gastrointestinal_Stromal_Tumors_as_Revealed_by_Conventional_and_Array_based_Comparative_Genomic_Hybridization"><img alt="Research paper thumbnail of Genomic Alterations in Gastrointestinal Stromal Tumors as Revealed by Conventional and Array-based Comparative Genomic Hybridization" class="work-thumbnail" src="https://attachments.academia-assets.com/47860858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598202/Genomic_Alterations_in_Gastrointestinal_Stromal_Tumors_as_Revealed_by_Conventional_and_Array_based_Comparative_Genomic_Hybridization">Genomic Alterations in Gastrointestinal Stromal Tumors as Revealed by Conventional and Array-based Comparative Genomic Hybridization</a></div><div class="wp-workCard_item"><span>Cancer Genomics Proteomics</span><span>, Mar 1, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gastrointestinal stromal tumor (GIST) is the most commonly occurring mesenchymal neoplasm of the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gastrointestinal stromal tumor (GIST) is the most commonly occurring mesenchymal neoplasm of the gastrointestinal tract, accounting for 80 percent of these tumors. GIST is highly unresponsive to standard chemotherapy, particularly in patients with advanced or metastatic disease. Recent molecular studies have shown that activating c-kit (KIT) mutations are detectable in a large proportion (>75%) of tumors, between 78% (1) and 89% (2). Approximately 30% of tumors without an identifiable KIT mutation exhibit PDGFRA mutations . Furthermore, the KIT mutations are heterogeneous, some being known to confer a relatively better prognosis than others (1). Gross cytogenetic abnormalities associated with GIST appear to be similar regardless of whether a KIT mutation is identified. The molecular genetic alterations associated with multistep GIST tumorigenesis, particularly those which confer intrinsic or acquired resistance to both standard as well as targeted therapeutic approaches, however, are not fully recognized. As an initial approach to identify chromosomal sites of candidate gene(s), which may predict overall clinical and biologic behavior of GISTs, as they relate to response to the specific therapeutic drug Gleevec, we analyzed six GIST samples using both conventional as well as array-based Comparative Genomic Hybridization (CGH). The common abnormalities detected by CGH in low and high grade tumors included loss of all or part of chromosome 14; an entire chromosome 14 was 105</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cfad1564d966eb3b5dc07e14f3dac6b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860858,"asset_id":27598202,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860858/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598202"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598202"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598202; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598201"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598201/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo"><img alt="Research paper thumbnail of Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/47860863/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598201/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo">Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, Mar 1, 1993</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ccd9bee86ef3397b3f591cf1471a5b58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860863,"asset_id":27598201,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860863/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598201"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598201"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598201; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598200"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598200/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity"><img alt="Research paper thumbnail of Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/47860867/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598200/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity">Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monoox...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monooxygenase to phenol. Further hydroxylation of phenol by cytochrome P-450 monooxygenase results in the formation of mainly hydroquinone, which accumulates in the bone marrow. Bone marrow contains high levels of myeloperoxidase. Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase. N o hydroquinone formation was detected in the absence of myeloperoxidase. At low concentrations superoxide disniutase stimulated, but at high concentrations inhibited. the conversion of phenol to hydroquinone. The inhibitory effect at high superoxide dismutase concentrations indicates that the active hydroxylating species of myeloperoxidase is not derived from its interaction with hydrogen peroxide. Furthermore, catalase a hydrogen peroxide scavenger, was found to have no significant effect on hydroxylation of phenol to hydroquinone. supporting the lack of hydrogen peroxide involvement. Mannitol (a hydroxyl radical scavenger) was found to have no inhibitory effect, but histidine (a singlet oxygen scavenger) inhibited hydroquinone formation. Based on these results we postulate that a myeloperoxidasesuperoxide complex spontaneously rearranges to generate singlet oxygen and that this singlet oxygen is responsible for phenol hydroxylation to hydroquinone. These results also suggest that myeloperoxidase dependent hydroquinone formation could play a role in the production and accumulation of hydroquinone in bone marrow. the target organ of benzene-induced myelotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6e6036422d38faaa48b5a40c5c01571c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860867,"asset_id":27598200,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860867/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598200"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598200"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598200; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598199"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598199/T%CE%B2R_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele"><img alt="Research paper thumbnail of TβR-I(6A) Is a Candidate Tumor Susceptibility Allele" class="work-thumbnail" src="https://attachments.academia-assets.com/47860862/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598199/T%CE%B2R_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele">TβR-I(6A) Is a Candidate Tumor Susceptibility Allele</a></div><div class="wp-workCard_item"><span>Cancer Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously described a type I transforming growth factor (TGF)-␤ receptor (T␤R-I) polymor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously described a type I transforming growth factor (TGF)-␤ receptor (T␤R-I) polymorphic allele, T␤R-I(6A), that has a deletion of three alanines from a nine-alanine stretch. We observed a higher than expected number of T␤R-I(6A) homozygotes among tumor and nontumor DNA from patients with a diagnosis of cancer. To test the hypothesis that T␤R-I(6A) homozygosity is associated with cancer, we performed a case-control study in patients with a diagnosis of cancer and matched healthy individuals with no history of cancer and who were identical in their gender and their geographical and ethnic background to determine the relative germ-line frequencies of this allele. We found nine T␤R-I(6A) homozygotes among 851 patients with cancer. In comparison, there were no T␤R-I(6A) homozygotes among 735 healthy volunteers (P < 0.01). We also observed an excess of T␤R-I(6A) heterozygotes in cancer cases compared to controls (14.6% versus 10.6%; P ‫؍‬ 0.02, Fisher's exact test). A subset analysis revealed that 4 of 112 patients with colorectal cancer were T␤R-I(6A) homozygotes (P < 0.01). Using mink lung epithelial cell lines devoid of T␤R-I, we established stably transfected T␤R-I and T␤R-I(6A) cell lines. We found that, compared to T␤R-I, T␤R-I(6A) was impaired as a mediator of TGF-␤ antiproliferative signals. We conclude that T␤R-I(6A) acts as a tumor susceptibility allele that may contribute to the development of cancer, especially colon cancer, by means of reduced TGF-␤-mediated growth inhibition. (J.M.). The abbreviations used are: TGF, transforming growth factor.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7426b7c5c9329828caac12935c578ca4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860862,"asset_id":27598199,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860862/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598199"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598199"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598199; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598199]").text(description); $(".js-view-count[data-work-id=27598199]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598199; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598199']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7426b7c5c9329828caac12935c578ca4" } } $('.js-work-strip[data-work-id=27598199]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598199,"title":"TβR-I(6A) Is a Candidate Tumor Susceptibility Allele","internal_url":"https://www.academia.edu/27598199/T%CE%B2R_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860862/thumbnails/1.jpg","file_name":"5678.full.pdf","download_url":"https://www.academia.edu/attachments/47860862/download_file","bulk_download_file_name":"TR_I_6A_Is_a_Candidate_Tumor_Susceptibi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860862/5678.full-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DTR_I_6A_Is_a_Candidate_Tumor_Susceptibi.pdf\u0026Expires=1739736096\u0026Signature=EKxMLBAp8swQegCq~Wbk7-fhaX9720zDv7wCQWmmdImpZi0oMs5cC0Vv2VeDaF0NLnbrZuiPsZLGrwa0KWWk9JnqSs3uHmUATrbOAz5bFiS6Th2EogiVJ4lHDH~uq7HfV~RkLt~deE1rf9qd0jZ3Gp-V7IS8bl4etH-tge4QlPSDY~D6xnJN1RBUS5CTwxO~2wmYyHUSAgnjq-ctJu8CGNmy5MKhnvCRLZnsFZCPX2giWNCtRER-LezuaYPZPJgma2zGve4g96jY8iKPjjTK-GCS49K6gwwM3YHLO80j87Z7oS8zQBNXYuwHyHsByPaOtrOlxqrUDYf1evVZO3xPxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598198"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598198/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo"><img alt="Research paper thumbnail of Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/47860855/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598198/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo">Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is metabo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is metabolized by cytochrome P450 2E1 to various phenolic metabolites which accumulate in the bone marrow. Bone marrow contains high levels of myeloperoxidase which can catalyze the further metabolism of the phenolic metabolites to reactive free radical species. Redox cycling of these free radical species produces active oxygen. This active oxygen may damage cellular DNA (known as oxidative DNA damage) and induce genotoxic effects. Here we report the induction of oxidative DNA damage by benzene and its phenolic metabolites in HL60 cells in vitro and in the bone marrow of C57BL/6 x C3H F1 mice in vivo utilizing 8-hydroxy-2&#39;-deoxyguanosine as a marker. HL60 cells (a human leukemia cell line) contain high levels of myeloperoxidase and were used as an in vitro model system. Exposure of these cells to phenol, hydroquinone, and 1,2,4-benzenetriol resulted in an increased level of oxidative DNA dama...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65f575fa5206bc7c8150f49a91fce64b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860855,"asset_id":27598198,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860855/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598198"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598198"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598198; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598197"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598197/Effect_of_Phenol_and_Catechol_on_the_Kinetics_of_Human_Myeloperoxidase_Dependent_Hydroquinone_Metabolism"><img alt="Research paper thumbnail of Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598197/Effect_of_Phenol_and_Catechol_on_the_Kinetics_of_Human_Myeloperoxidase_Dependent_Hydroquinone_Metabolism">Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PremaKolachana">Prema Kolachana</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://manipal.academia.edu/SubrahmanyamVangala">Subrahmanyam Vangala</a></span></div><div class="wp-workCard_item"><span>Advances in Experimental Medicine and Biology</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598197"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598197"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598197; 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</script> <div class="js-work-strip profile--work_container" data-work-id="27598196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598196/Induction_of_kinetochore_positive_micronuclei_in_human_lymphocytes_by_the_anti_fungal_drug_griseofulvin"><img alt="Research paper thumbnail of Induction of kinetochore-positive micronuclei in human lymphocytes by the anti-fungal drug griseofulvin" class="work-thumbnail" src="https://attachments.academia-assets.com/47860871/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598196/Induction_of_kinetochore_positive_micronuclei_in_human_lymphocytes_by_the_anti_fungal_drug_griseofulvin">Induction of kinetochore-positive micronuclei in human lymphocytes by the anti-fungal drug griseofulvin</a></div><div class="wp-workCard_item"><span>Mutation Research/Genetic Toxicology</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Griseofulvin (GF) is a widely used antifungal drug for the treatment of superficial dermatomycose...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Griseofulvin (GF) is a widely used antifungal drug for the treatment of superficial dermatomycoses. However, because GF is carcinogenic and teratogenic in animal models there is considerable concern regarding its clinical application. Further, it produces numerical chromosome aberrations in human lymphocytes and cell lines. There are conflicting reports on the ability of GF to induce structural chromosomal aberrations. Here, we show GF induces micronucleus formation both in isolated peripheral lymphocytes and lymphocytes from whole blood cultures. An antikinetochore antibody was used to distinguish micronuclei with acentric chromosome fragments (kinetochorenegative) and from those containing whole chromosomes (kinetochore-positive). The micronuclei formed were 99% kinetochore-positive in isolated lymphocytes. In addition, GF was able to alter the cell cycle kinetics of lymphocytes, thereby increasing the percentage of triploid cells. We conclude that GF is a strong aneuploidy-inducing agent in peripheral human lymphocytes and produces effects at concentrations which should be detectable in the blood of persons undergoing therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a4a05be571948964d592aa2bda7654f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860871,"asset_id":27598196,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860871/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598196"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598196"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598196; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598196]").text(description); $(".js-view-count[data-work-id=27598196]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598196; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598196']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1a4a05be571948964d592aa2bda7654f" } } $('.js-work-strip[data-work-id=27598196]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598196,"title":"Induction of kinetochore-positive micronuclei in human lymphocytes by the anti-fungal drug griseofulvin","internal_url":"https://www.academia.edu/27598196/Induction_of_kinetochore_positive_micronuclei_in_human_lymphocytes_by_the_anti_fungal_drug_griseofulvin","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860871,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860871/thumbnails/1.jpg","file_name":"Induction_of_kinetochore-positive_micron20160807-4245-xe2a60.pdf","download_url":"https://www.academia.edu/attachments/47860871/download_file","bulk_download_file_name":"Induction_of_kinetochore_positive_micron.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860871/Induction_of_kinetochore-positive_micron20160807-4245-xe2a60-libre.pdf?1470580427=\u0026response-content-disposition=attachment%3B+filename%3DInduction_of_kinetochore_positive_micron.pdf\u0026Expires=1739736096\u0026Signature=LmfTGkX2YHHsFZJw16tnsyYZYoD90EsQpzHHy6G1oD~CR-w5xKb70JSfCH53P07FUAUkwXc33fT8eH-ejFhr9hwxjG-Zby5Yntu7LMaXqenuk0yM7PKiG6wiu043JCGPNns27G1TgE-z-Yt4A6iXSJ9qZ9~uaIG8RoZorjCRuu8~m1rAenOwIIqoCIlzl0T7IY23fFj2X3-3kuGaF0tDJ7SBcV~YZsdKd05M3iMDtptv1rWAmd~Bjqln~0iv86HtHgoXaUs3BuU63sOelE2u8yoZ24LUt8Pi1AI-386EoQ64sNRgxywhboGFuZLsH52pY~mi1r~0vhOe99jfcIFdlg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598195"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598195/Rare_variants_of_ATM_and_risk_for_Hodgkins_disease_and_radiation_associated_breast_cancers"><img alt="Research paper thumbnail of Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598195/Rare_variants_of_ATM_and_risk_for_Hodgkins_disease_and_radiation_associated_breast_cancers">Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers</a></div><div class="wp-workCard_item"><span>Clinical cancer research : an official journal of the American Association for Cancer Research</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may have an increased susceptibility to radiation-induced breast cancer (BC) after treatment for Hodgkin&#39;s disease (HD). We next sought to determine the frequency of ATM variants in patients with Hodgkin&#39;s lymphoma, regardless of coexisting BC, compared with healthy volunteers. Full sequence analysis of ATM was performed on cDNA from peripheral blood lymphocytes from 37 cases of BC after therapeutic radiation therapy for HD and 27 comparison cases with HD and no BC treated during the same time period. The frequency of ATM variants was analyzed in the total group of 64 cases of HD and compared to allele frequencies in 128 ethnically matched controls from the same geographical region. No protein-truncating ATM mutations were observed in cases with HD with or without BC. Missense mutations were more frequent in the cohort with HD compared with patients with BC following HD (P = 0.02). ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598195"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598195"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598195; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598195]").text(description); $(".js-view-count[data-work-id=27598195]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598195; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598195']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598195]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598195,"title":"Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers","internal_url":"https://www.academia.edu/27598195/Rare_variants_of_ATM_and_risk_for_Hodgkins_disease_and_radiation_associated_breast_cancers","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598194/Frequency_of_CHEK2_1100delC_in_New_York_breast_cancer_cases_and_controls"><img alt="Research paper thumbnail of Frequency of CHEK2*1100delC in New York breast cancer cases and controls" class="work-thumbnail" src="https://attachments.academia-assets.com/47860857/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598194/Frequency_of_CHEK2_1100delC_in_New_York_breast_cancer_cases_and_controls">Frequency of CHEK2*1100delC in New York breast cancer cases and controls</a></div><div class="wp-workCard_item"><span>BMC medical genetics</span><span>, Jan 15, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The 1100delC CHEK2 allele has been associated with a 1.4-4.7 fold increased risk for breast cance...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The 1100delC CHEK2 allele has been associated with a 1.4-4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1-1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear. We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the CHEK2*1100delC. The overall frequency of the 1100delC was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls. The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d6ca7f710f2ecdff81a44c73457fca0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860857,"asset_id":27598194,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860857/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598194]").text(description); $(".js-view-count[data-work-id=27598194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d6ca7f710f2ecdff81a44c73457fca0" } } $('.js-work-strip[data-work-id=27598194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598194,"title":"Frequency of CHEK2*1100delC in New York breast cancer cases and controls","internal_url":"https://www.academia.edu/27598194/Frequency_of_CHEK2_1100delC_in_New_York_breast_cancer_cases_and_controls","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860857,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860857/thumbnails/1.jpg","file_name":"1471-2350-4-1.pdf","download_url":"https://www.academia.edu/attachments/47860857/download_file","bulk_download_file_name":"Frequency_of_CHEK2_1100delC_in_New_York.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860857/1471-2350-4-1-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DFrequency_of_CHEK2_1100delC_in_New_York.pdf\u0026Expires=1739736096\u0026Signature=O0ikKAXSbnj06gY7e2~IEQOYWDXhF~Raz0sx55Mjp61cwowsnRIzCCTzRl7pr7IcuKS0PPYOou2PieDkBvvyq-gKGeCOHYrN7i4sIP2xL9RS4w6AWPEgVdCLRQqPLof-O06vZAMkUokWJUpTR6DDSMJkjGm4iEjDbjL-88wBfvLaa-aFvHb4v3winRm0I5nT188l8~6zIilSTWVD5k0DAl7uq5nKBnXbJ5-ZizrfAzc6Vp8ESDGDrxry4KqJjtqyFhO9~1Dd3VChzWZ3huh4bwpHUKejZWbv~9inKXwJvRmQdDSL60IO4jRYfFAKn-nwj25MMDFV2kbT26VaqQg5GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598193/Increased_Translocations_and_Aneusomy_in_Chromosomes_8_and_21_Among_Workers_Exposed_to_Benzene1"><img alt="Research paper thumbnail of Increased Translocations and Aneusomy in Chromosomes 8 and 21 Among Workers Exposed to Benzene1" class="work-thumbnail" src="https://attachments.academia-assets.com/47860843/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598193/Increased_Translocations_and_Aneusomy_in_Chromosomes_8_and_21_Among_Workers_Exposed_to_Benzene1">Increased Translocations and Aneusomy in Chromosomes 8 and 21 Among Workers Exposed to Benzene1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chromosome aberrations in peripheral blood lymphocytes have been used for many years to monitor h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chromosome aberrations in peripheral blood lymphocytes have been used for many years to monitor human populations exposed to potential carcinogens. Recent reports have confirmed the validity of this approach by demonstrating that elevated levels of chromosome aberrations in lym phocytes are associated with subsequent increased cancer risk, especially for increased mortality from hematological malignancies including acute myeloid leukemia (AMD. We</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="14e9c07dea87431d43690e3030f982df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860843,"asset_id":27598193,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860843/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598193]").text(description); $(".js-view-count[data-work-id=27598193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "14e9c07dea87431d43690e3030f982df" } } $('.js-work-strip[data-work-id=27598193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598193,"title":"Increased Translocations and Aneusomy in Chromosomes 8 and 21 Among Workers Exposed to Benzene1","internal_url":"https://www.academia.edu/27598193/Increased_Translocations_and_Aneusomy_in_Chromosomes_8_and_21_Among_Workers_Exposed_to_Benzene1","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860843,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860843/thumbnails/1.jpg","file_name":"2176.pdf","download_url":"https://www.academia.edu/attachments/47860843/download_file","bulk_download_file_name":"Increased_Translocations_and_Aneusomy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860843/2176-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Translocations_and_Aneusomy_in.pdf\u0026Expires=1739736096\u0026Signature=f8ne7cT0bVOOwu-upfAO-2YyyXG4M-q-8fvx2PpCSUqNcwBmCTrrJkFWEykKbJXoJcRngWCQYLjW5XZMwlpS1Hn101M~Q-xsXJrY8Br4fQOezV7BfVAdBEsTHj6QFEth9lU1HCHPfqfF8iCJV2gbIe1Kos3WfhDVwW5HIki-ucIOxxj8MsWnNAxyOKdwFwruBbt1NjdLO7fLELpbWjWXgz59-7s3ba4xfN7iHA2lwXecGriN6kSEEdyY3i2oUOatImB33MxStBDCPAFxthBhjy2bFVWZ2~Cw3TtWwudOGYoDguRTQlgXjnftmHbkRQgWhOq3fGJ90iipr6B9YyxvPA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":47860844,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860844/thumbnails/1.jpg","file_name":"2176.pdf","download_url":"https://www.academia.edu/attachments/47860844/download_file","bulk_download_file_name":"Increased_Translocations_and_Aneusomy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860844/2176-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Translocations_and_Aneusomy_in.pdf\u0026Expires=1739736096\u0026Signature=eTGIL5z7kkTSZM6DnrdSh9KLRi9cfpAznSUix~L9291inCc3yYJ1gY3vyfEqJNnzQNhgEOJ5J14O~lLYSxhYAfFzeDwh1GppBuhW~bkUweFICuqZWRLiWeYjFeVjzSJBkir4Wj8FAG-UrogoZLnaRgOmE4oIRvOyIj-wYRENC3k8~Jf-NZk~8ttIpSdekj-9sBwhDGIPT3huDcZv-hmqyC1tE6J3V4nAzRXFp09TTvJwHfof9N3OgSU1~NHFq0wkpZqQlt66wiRSDZQsY4dWVWb-LNm~-gZUrXgsGvgX75p7Qf1fDUTGBVstFVB4ohb-ZBBc66a9XS3c5IIY1ndYNg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598192/TbR_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele"><img alt="Research paper thumbnail of TbR-I(6A) Is a Candidate Tumor Susceptibility Allele" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598192/TbR_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele">TbR-I(6A) Is a Candidate Tumor Susceptibility Allele</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously described a type I transforming growth factor (TGF)-b receptor (TbR-I) polymor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously described a type I transforming growth factor (TGF)-b receptor (TbR-I) polymorphic allele, TbR-I(6A), that has a deletion of three alanines from a nine-alanine stretch. We observed a higher than expected number,of TbR-I(6A) homozygotes among tumor and nontumor DNA from patients with a diagnosis of cancer. To test the hypothesis that TbR-I(6A) homozygosity is associated with cancer,</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598192]").text(description); 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In intact animals, lesions (adducts) excised from DNA are transported from the cell through the circulation and excreted in urine. In bacteria, DNA adducts are excreted directly into the medium. In</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598191]").text(description); $(".js-view-count[data-work-id=27598191]").attr('title', description).tooltip(); 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598190/BLM_Heterozygosity_and_the_Risk_of_Colorectal_Cancer"><img alt="Research paper thumbnail of BLM Heterozygosity and the Risk of Colorectal Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/47860860/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598190/BLM_Heterozygosity_and_the_Risk_of_Colorectal_Cancer">BLM Heterozygosity and the Risk of Colorectal Cancer</a></div><div class="wp-workCard_item"><span>Science</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5325a72078a0593c7b0ea96f8d8e685c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860860,"asset_id":27598190,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860860/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598190]").text(description); $(".js-view-count[data-work-id=27598190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5325a72078a0593c7b0ea96f8d8e685c" } } $('.js-work-strip[data-work-id=27598190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598190,"title":"BLM Heterozygosity and the Risk of Colorectal Cancer","internal_url":"https://www.academia.edu/27598190/BLM_Heterozygosity_and_the_Risk_of_Colorectal_Cancer","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860860,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860860/thumbnails/1.jpg","file_name":"BLM_heterozygosity_and_the_risk_of_color20160807-31888-77oiyy.pdf","download_url":"https://www.academia.edu/attachments/47860860/download_file","bulk_download_file_name":"BLM_Heterozygosity_and_the_Risk_of_Color.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860860/BLM_heterozygosity_and_the_risk_of_color20160807-31888-77oiyy-libre.pdf?1470580425=\u0026response-content-disposition=attachment%3B+filename%3DBLM_Heterozygosity_and_the_Risk_of_Color.pdf\u0026Expires=1739736096\u0026Signature=Y8HV0fl3Ql63WENWf1XlYQhgFUMSPoWB0Syo0ddPgLjwRLH-XUL8piNNwVgPNgBCCquCfwS7YYOqAwvrFLQ4xf7J5zlQ7YnhafJPVeVzjcurz4jfJXHKrpaAkynr6mWxObB7a9vX3zwl3nTxKWyFHYwasLX76NW44rHXA~ratzASEhYeN4t5RgJgnYIii2yzjtGySFyzXc8w5GGkebpIixzIZZd6wY6iuYsCXbcOxHW3kGljS9AfgmFEeimVdXHSvCrqvbPqEzOT8t1wXCFNYxgfKFaElpVgMqt06TMn6J3p1IHevcBUucNdzVbo~iOf3BtM3pjOPFbq394K9~OWzg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598189/Benzene_induces_gene_duplicating_but_not_gene_inactivating_mutations_at_the_glycophorin_A_locus_in_exposed_humans"><img alt="Research paper thumbnail of Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans" class="work-thumbnail" src="https://attachments.academia-assets.com/47860861/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598189/Benzene_induces_gene_duplicating_but_not_gene_inactivating_mutations_at_the_glycophorin_A_locus_in_exposed_humans">Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. U...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple gene mutation assays. Benzene and its metabolites do, however, produce chromosomal damage in a variety of systems. Here, we have used the glycophorin A (GPA) gene loss mutation assay to evaluate the nature of DNA damage produced by benzene in 24 workers heavily exposed to benzene and 23 matched control individuals in Shanghai, China. The GPA assay identifies stem cell or precursor erythroid cell mutations expressed in peripheral erythrocytes of MN-heterozygous subjects, distinguishing the NN and N0 mutant variants. A significant increase in the NN GPA variant cell frequency (Vf) was found in benzene-exposed workers as compared with unexposed control individuals (mean ± SEM, 13.9 ± 1.7 per million cells vs. 7.4 + 1.1 per million cells in control individuals; P = 0.0002). In contrast, no significant difference existed between the two groups for the N0 Vf (9.1 + 0.9 vs. 8.8 + 1.8 per million cells; P = 0.21). Further, lifetime cumulative occupational exposure to benzene was associated with the NN Vf (P = 0.005) but not with the N0 Vf (P = 0.31), suggesting that NN mutations occur in longer-lived bone marrow stem cells. NN variants result from loss of the GPA M allele and duplication of the N allele, presumably through recombination mechanisms, whereas N0 variants arise from gene inactivation, presumably due to point mutations and deletions. Thus, these results suggest that benzene produces gene-duplicating mutations but does not produce gene-inactivating mutations at the GPA locus in bone marrow cells of humans exposed to high benzene levels. This finding is consistent with data on the genetic toxicology of benzene and its metabolites and adds further weight to the hypothesis that chromosome damage and mitotic recombination are important in benzene-induced leukemia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="51add9f3abb9601a51d9ccb7147c63b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860861,"asset_id":27598189,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860861/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598189; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598188/Genotoxicity_of_malathion_in_human_lymphocytes_assessed_using_the_micronucleus_assay_in_vitro_and_in_vivo_A_study_of_malathion_exposed_workers"><img alt="Research paper thumbnail of Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers" class="work-thumbnail" src="https://attachments.academia-assets.com/47860872/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598188/Genotoxicity_of_malathion_in_human_lymphocytes_assessed_using_the_micronucleus_assay_in_vitro_and_in_vivo_A_study_of_malathion_exposed_workers">Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers</a></div><div class="wp-workCard_item"><span>Mutation Research/Genetic Toxicology and Environmental Mutagenesis</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aerial application of malathion, a widely used organophosphate insecticide, has raised public...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aerial application of malathion, a widely used organophosphate insecticide, has raised public concerns about potential adverse health effects. We therefore studied micronucleus formation in human lymphocytes as a biomarker of genotoxicity both in vitro and in vivo. Lymphocytes were cultured either as whole blood or after Ficoll isolation and treated Ž with malathion in doses from 5 to 100 mgrml for 48 h. A significant increase in micronucleated cells 47.5r1000 versus . Ž . 16.0r1000 in DMSO control, p -0.001 was found in isolated lymphocytes at high dose levels 75-100 mgrml , Ž . concurrent with cytotoxicity and a strong inhibition of proliferation p -0.001 . Many of the treated cells also possessed multiple micronuclei. Antikinetochore-antibody staining revealed that the majority of malathion-induced micronuclei were kinetochore-negative. A significant dose-response was also observed in whole blood cultures, although the increase in Ž . micronucleated cells was lower than in isolated lymphocyte cultures p s 0.03 . When the same technique was applied to lymphocytes of 38 intermittently malathion-exposed workers involved in the Mediterranean Fruit Fly Eradication Program in California, no change in either proliferation or micronucleus level was observed compared with an unexposed control group. We conclude that malathion has a relatively low potential to cause chromosome damage in vitro, and corresponding doses are much higher than ones that even professional applicators are likely to be exposed to in vivo. The potential risk of chromosome damage for malathion exposure in vivo is therefore relatively low. More studies are needed to assess the possibility of interaction of malathion with other pesticides through combined exposure. $17.00 Copyright q 1997 Elsevier Science B.V. All rights reserved.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae5c91f4f69c22e2b92ce28a19647aad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860872,"asset_id":27598188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860872/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598188; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598186/A636P_is_associated_with_early_onset_colon_cancer_in_Ashkenazi_Jews"><img alt="Research paper thumbnail of A636P is associated with early-onset colon cancer in Ashkenazi Jews" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598186/A636P_is_associated_with_early_onset_colon_cancer_in_Ashkenazi_Jews">A636P is associated with early-onset colon cancer in Ashkenazi Jews</a></div><div class="wp-workCard_item"><span>Journal of the American College of Surgeons</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatou...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatous polyposis from mutations of APC, or hereditary nonpolyposis colorectal cancer, resulting from mutations of MSH2, MLH1, MSH6, or other genes. Previously, we described a rare founder mutation MSH2*1906C &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; G in Ashkenazi Jews that was found in 8 of 1,345 individuals (0.6%) of Ashkenazi descent with colorectal cancer. This study seeks to characterize the proportion of individuals of Ashkenazi heritage with very early-onset colon cancer (diagnosed at age 40 or younger) that could be attributed to MSH2*1906C&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;G. We analyzed the carrier frequency of MSH2*1906C&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;G in paraffin samples from 31 Jewish patients age 40 or less, diagnosed with colorectal cancer at Memorial Sloan-Kettering and lymphocyte-derived DNA from 10 patients. We did not select for family history. Genotyping for MSH2*1906C&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;G was performed by polymerase chain reaction and restriction enzyme digestion methods. We detected the MSH2*1906G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;C mutation in 3 of the 41 samples (7.14%) of patients who had colorectal cancer diagnosed at age 40 or younger. This incidence is significantly greater than the 8 in 1,345 (0.6%) we observed for cases of colorectal cancer in Ashkenazi Jews not selected for age (p = 0.004). Although very rare in the population, MSH2*1906G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;C is found at an increased frequency in young Jewish patients with colorectal cancer. These results suggest that testing for the MSH2*1906G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;C mutation should be included in the evaluation of Ashkenazi Jewish individuals diagnosed with early-onset colon cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598186]").text(description); $(".js-view-count[data-work-id=27598186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598186,"title":"A636P is associated with early-onset colon cancer in Ashkenazi Jews","internal_url":"https://www.academia.edu/27598186/A636P_is_associated_with_early_onset_colon_cancer_in_Ashkenazi_Jews","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598185/Frequency_of_BRCA1_and_BRCA2_Mutations_in_Unselected_Ashkenazi_Jewish_Patients_With_Colorectal_Cancer"><img alt="Research paper thumbnail of Frequency of BRCA1 and BRCA2 Mutations in Unselected Ashkenazi Jewish Patients With Colorectal Cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598185/Frequency_of_BRCA1_and_BRCA2_Mutations_in_Unselected_Ashkenazi_Jewish_Patients_With_Colorectal_Cancer">Frequency of BRCA1 and BRCA2 Mutations in Unselected Ashkenazi Jewish Patients With Colorectal Cancer</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mutations in BRCA1 and BRCA2 that predispose to breast and ovarian cancer are detected in approxi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mutations in BRCA1 and BRCA2 that predispose to breast and ovarian cancer are detected in approximately 2.5% of the Ashkenazi Jewish population. To explore whether carriers of Ashkenazi founder mutations in BRCA1 or BRCA2 have an increased risk for colorectal cancer, we screened 586 unselected Ashkenazi Jewish case patients with colorectal cancer for the three common founder mutations in BRCA1 and BRCA2. We identified six carriers (1.02%) among these case patients. After adjusting for age at diagnosis and sex by use of logistic regression analysis, we compared the incidence of carriers in this group of 586 case patients with that of 5012 Ashkenazi Jewish control subjects without a known history of colorectal cancer. The presence of a founder BRCA mutation was not associated with the risk of colorectal cancer (relative risk = 0.50, 95% confidence interval = 0.22 to 1.14). We thus recommend that counseling for colorectal cancer screening and prevention in individuals with BRCA mutations be based on the personal and family history of colorectal cancer or associated syndromic malignancies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598185]").text(description); $(".js-view-count[data-work-id=27598185]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598185']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598185]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598185,"title":"Frequency of BRCA1 and BRCA2 Mutations in Unselected Ashkenazi Jewish Patients With Colorectal Cancer","internal_url":"https://www.academia.edu/27598185/Frequency_of_BRCA1_and_BRCA2_Mutations_in_Unselected_Ashkenazi_Jewish_Patients_With_Colorectal_Cancer","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598184"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598184/MSH6_germline_mutations_are_rare_in_colorectal_cancer_families"><img alt="Research paper thumbnail of MSH6 germline mutations are rare in colorectal cancer families" class="work-thumbnail" src="https://attachments.academia-assets.com/47860870/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598184/MSH6_germline_mutations_are_rare_in_colorectal_cancer_families">MSH6 germline mutations are rare in colorectal cancer families</a></div><div class="wp-workCard_item"><span>International Journal of Cancer</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Germline mutations in MSH6 can cause HNPCC, which is associated with a tumor phenotype featuring ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Germline mutations in MSH6 can cause HNPCC, which is associated with a tumor phenotype featuring MSI. However, tumors arising in persons with disease-causing mutations of MSH6 may or may not exhibit MSI. We used D-HPLC to screen for germline mutations in the promoter region, the coding region and the 3-UTR of MSH6. Eighty-four families, enrolled on the basis of Amsterdam I and II criteria (HNPCC families) and less stringent criteria (HNPCC-like families), were tested for MMR gene mutations; 27 families had a disease-causing mutation in MLH1 or MSH2, and the remaining 57 families were tested for mutations in MSH6. Two protein-truncating mutations were identified in each of 2 families fulfilling the Amsterdam I criteria, being present in persons affected with early-onset colorectal cancers exhibiting MSI. Immunohistochemical analysis showed that expression of both MSH2 and MSH6 proteins was lost in the cancer cells of the 2 mutation carriers but only MSH6 protein expression was lost in 2 adenomatous polyps. A third possibly disease-causing mutation was found in a person affected with a tumor that did not exhibit MSI. In addition, we found 4 new polymorphisms and determined that neither of the 2 studied by association analysis conferred susceptibility to colorectal or endometrial cancer. Altogether, our results indicate that disease-causing germline mutations of MSH6 are rare in HNPCC and HNPCC-like families.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d343da684ee5ba4cf57c1c4aaf4959bc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860870,"asset_id":27598184,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860870/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598184"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598184"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598184; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598184]").text(description); $(".js-view-count[data-work-id=27598184]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598184; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598184']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d343da684ee5ba4cf57c1c4aaf4959bc" } } $('.js-work-strip[data-work-id=27598184]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598184,"title":"MSH6 germline mutations are rare in colorectal cancer families","internal_url":"https://www.academia.edu/27598184/MSH6_germline_mutations_are_rare_in_colorectal_cancer_families","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860870,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860870/thumbnails/1.jpg","file_name":"Peterlongo_P._et_al._MSH6_germline_mutat20160807-2860-139qzv1.pdf","download_url":"https://www.academia.edu/attachments/47860870/download_file","bulk_download_file_name":"MSH6_germline_mutations_are_rare_in_colo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860870/Peterlongo_P._et_al._MSH6_germline_mutat20160807-2860-139qzv1-libre.pdf?1470580425=\u0026response-content-disposition=attachment%3B+filename%3DMSH6_germline_mutations_are_rare_in_colo.pdf\u0026Expires=1739736096\u0026Signature=WNjptEzcTrPZGZReCw62O918rSxh4DgpoIlR-2CcV62-QIkl8j0KGwvbRD1veRmh4-A1OaOvVTYBx-o1JG5CFplwmqxFXeC~4fJCJ90WrNt9uRLNKCn5PuzReSgls9OKQ~ZCjQK3hOkoEq8ZhOnQ3ijakbQTz4kjz8fcO5z31A-rmI3eWHIdHayo5BEII19ciIgBa4tdsUNB6uQ-vJR1x-sbzWzm822Ubh~liK3j8vljhBYuaIqTzCtxH~GAP1KBY53NKa3-QG~R0u8~-2iiDWGN1A7vbVxUTVBqxc~vYZPpP9OJCFVe3jO~VPogk9tEjvl6iSWVeX4k1qZx8Sshag__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598183"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598183/Absence_of_post_transcriptional_RNA_modifications_ofBCL10_in_human_malignant_mesothelioma_and_colorectal_cancer"><img alt="Research paper thumbnail of Absence of post-transcriptional RNA modifications ofBCL10 in human malignant mesothelioma and colorectal cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598183/Absence_of_post_transcriptional_RNA_modifications_ofBCL10_in_human_malignant_mesothelioma_and_colorectal_cancer">Absence of post-transcriptional RNA modifications ofBCL10 in human malignant mesothelioma and colorectal cancer</a></div><div class="wp-workCard_item"><span>Genes, Chromosomes and Cancer</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The BCL10 gene, located at 1p22, has been implicated in a number of human malignancies, including...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The BCL10 gene, located at 1p22, has been implicated in a number of human malignancies, including malignant mesotheliomas (MMs) and colorectal carcinomas. Subsequent reports, however, have revealed an absence of BCL10 mutations in genomic DNA from such tumors. It has been proposed that some abnormalities of this gene may be found only in RNA and not in genomic DNA, suggesting that BCL10 may be mutated post-transcriptionally, rather than at the genomic level. To explore this possibility, we performed SSCP mutation analysis and direct sequencing of cDNA from 17 MM cell lines displaying LOH in 1p22, 12 MM tumor specimens, and 11 colon carcinoma cell lines. SSCP revealed several different band shifts in these samples. The nucleotide changes observed in the cDNA samples were also seen in matched genomic DNA and corresponded to known polymorphisms in the general population. Thus, we conclude the BCL10 mutations are absent at the cDNA level, and that this gene does not undergo &amp;quot;molecular misreading.&amp;quot; Since BCL10 also does not possess mutations at the genomic DNA level, it can be ruled out as a gene involved in the pathogenesis of MM and colorectal cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598183"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598183]").text(description); $(".js-view-count[data-work-id=27598183]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598183']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598183]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598183,"title":"Absence of post-transcriptional RNA modifications ofBCL10 in human malignant mesothelioma and colorectal cancer","internal_url":"https://www.academia.edu/27598183/Absence_of_post_transcriptional_RNA_modifications_ofBCL10_in_human_malignant_mesothelioma_and_colorectal_cancer","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598182"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598182/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity"><img alt="Research paper thumbnail of Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/47860868/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598182/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity">Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity</a></div><div class="wp-workCard_item"><span>Free Radical Research</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monoox...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monooxygenase to phenol. Further hydroxylation of phenol by cytochrome P-450 monooxygenase results in the formation of mainly hydroquinone, which accumulates in the bone marrow. Bone marrow contains high levels of myeloperoxidase. Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase. N o hydroquinone formation was detected in the absence of myeloperoxidase. At low concentrations superoxide disniutase stimulated, but at high concentrations inhibited. the conversion of phenol to hydroquinone. The inhibitory effect at high superoxide dismutase concentrations indicates that the active hydroxylating species of myeloperoxidase is not derived from its interaction with hydrogen peroxide. Furthermore, catalase a hydrogen peroxide scavenger, was found to have no significant effect on hydroxylation of phenol to hydroquinone. supporting the lack of hydrogen peroxide involvement. Mannitol (a hydroxyl radical scavenger) was found to have no inhibitory effect, but histidine (a singlet oxygen scavenger) inhibited hydroquinone formation. Based on these results we postulate that a myeloperoxidasesuperoxide complex spontaneously rearranges to generate singlet oxygen and that this singlet oxygen is responsible for phenol hydroxylation to hydroquinone. These results also suggest that myeloperoxidase dependent hydroquinone formation could play a role in the production and accumulation of hydroquinone in bone marrow. the target organ of benzene-induced myelotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9588058525c8f3c3506184bd677008b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860868,"asset_id":27598182,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860868/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598182"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598182"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598182; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598182]").text(description); $(".js-view-count[data-work-id=27598182]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598182; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598182']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9588058525c8f3c3506184bd677008b8" } } $('.js-work-strip[data-work-id=27598182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598182,"title":"Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity","internal_url":"https://www.academia.edu/27598182/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860868,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860868/thumbnails/1.jpg","file_name":"Hydroxylation_of_Phenol_to_Hydroquinone_20160807-16752-1ir2t7.pdf","download_url":"https://www.academia.edu/attachments/47860868/download_file","bulk_download_file_name":"Hydroxylation_of_Phenol_to_Hydroquinone.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860868/Hydroxylation_of_Phenol_to_Hydroquinone_20160807-16752-1ir2t7-libre.pdf?1470580428=\u0026response-content-disposition=attachment%3B+filename%3DHydroxylation_of_Phenol_to_Hydroquinone.pdf\u0026Expires=1739736096\u0026Signature=TUQ36Tjr1v9WmZmR4S~dtYr42-lF04Dq93iEVDP5-I4silklzdChPf-8WzjayHorf~Kja1IOGLjizb6GT0uYWgoF4OyeBJL0eIJChtuMv~dueTSIiWzgvtb6d5OmglDF56KfCWHOTyfYR5To9AoF5Z0bfDVDqngWXwtlkM7rbiF6lEIKVpnZ2SEDc5n3sFwwAXgLtLMxIB6M8AMtMLuC9dvSIkbtm0KyB1ZzH8JSrolc2oOhEXTJ4MXW0hiJNqAc5fu19j4~qdWvcJpsUDFGvmgk-hQzsAsJoSfRnKZn3TSxRXozVs00t7MfPdAYBDloosTfTKiUwUZOcBKrJj8vTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="5616936" id="papers"><div class="js-work-strip profile--work_container" data-work-id="27598202"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598202/Genomic_Alterations_in_Gastrointestinal_Stromal_Tumors_as_Revealed_by_Conventional_and_Array_based_Comparative_Genomic_Hybridization"><img alt="Research paper thumbnail of Genomic Alterations in Gastrointestinal Stromal Tumors as Revealed by Conventional and Array-based Comparative Genomic Hybridization" class="work-thumbnail" src="https://attachments.academia-assets.com/47860858/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598202/Genomic_Alterations_in_Gastrointestinal_Stromal_Tumors_as_Revealed_by_Conventional_and_Array_based_Comparative_Genomic_Hybridization">Genomic Alterations in Gastrointestinal Stromal Tumors as Revealed by Conventional and Array-based Comparative Genomic Hybridization</a></div><div class="wp-workCard_item"><span>Cancer Genomics Proteomics</span><span>, Mar 1, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Gastrointestinal stromal tumor (GIST) is the most commonly occurring mesenchymal neoplasm of the ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Gastrointestinal stromal tumor (GIST) is the most commonly occurring mesenchymal neoplasm of the gastrointestinal tract, accounting for 80 percent of these tumors. GIST is highly unresponsive to standard chemotherapy, particularly in patients with advanced or metastatic disease. Recent molecular studies have shown that activating c-kit (KIT) mutations are detectable in a large proportion (>75%) of tumors, between 78% (1) and 89% (2). Approximately 30% of tumors without an identifiable KIT mutation exhibit PDGFRA mutations . Furthermore, the KIT mutations are heterogeneous, some being known to confer a relatively better prognosis than others (1). Gross cytogenetic abnormalities associated with GIST appear to be similar regardless of whether a KIT mutation is identified. The molecular genetic alterations associated with multistep GIST tumorigenesis, particularly those which confer intrinsic or acquired resistance to both standard as well as targeted therapeutic approaches, however, are not fully recognized. As an initial approach to identify chromosomal sites of candidate gene(s), which may predict overall clinical and biologic behavior of GISTs, as they relate to response to the specific therapeutic drug Gleevec, we analyzed six GIST samples using both conventional as well as array-based Comparative Genomic Hybridization (CGH). The common abnormalities detected by CGH in low and high grade tumors included loss of all or part of chromosome 14; an entire chromosome 14 was 105</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cfad1564d966eb3b5dc07e14f3dac6b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860858,"asset_id":27598202,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860858/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598202"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598202"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598202; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598202]").text(description); $(".js-view-count[data-work-id=27598202]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598202; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598202']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cfad1564d966eb3b5dc07e14f3dac6b7" } } $('.js-work-strip[data-work-id=27598202]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598202,"title":"Genomic Alterations in Gastrointestinal Stromal Tumors as Revealed by Conventional and Array-based Comparative Genomic Hybridization","internal_url":"https://www.academia.edu/27598202/Genomic_Alterations_in_Gastrointestinal_Stromal_Tumors_as_Revealed_by_Conventional_and_Array_based_Comparative_Genomic_Hybridization","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860858,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860858/thumbnails/1.jpg","file_name":"105.full.pdf","download_url":"https://www.academia.edu/attachments/47860858/download_file","bulk_download_file_name":"Genomic_Alterations_in_Gastrointestinal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860858/105.full-libre.pdf?1470580425=\u0026response-content-disposition=attachment%3B+filename%3DGenomic_Alterations_in_Gastrointestinal.pdf\u0026Expires=1739736096\u0026Signature=HYoxEU8cKSEgKXVJdJIKHuhC00pOMlrkVusGvhGUkjFNRb~gEE9unc0EzRFSYByFdJwMW0xNSSVTYmywnF4P3w2Rt5lJYZc-fiK6Spyt09c2veF1ka7RMdjbYrPp9vMtKoZTF9KGnMZHccghhLdDHG9YVNYBV70rUdfmJmjS~iUNCJDac80rIoYRVogFPd6t2TlctKWi1MtJkU-3UXTZonMfFtrhvnUymQa1x3eIjEXgGJ9orVKM~0mHq4Rujkm8R3T91g9U37A2XD7y2oiN-nt0ALI2Faa026WEnplw6j12aqMbsBFsAunndeMF9qEUyet0BxU79WYepUxBzVcKrA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598201"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598201/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo"><img alt="Research paper thumbnail of Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/47860863/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598201/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo">Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, Mar 1, 1993</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ccd9bee86ef3397b3f591cf1471a5b58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860863,"asset_id":27598201,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860863/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598201"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598201"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598201; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598201]").text(description); $(".js-view-count[data-work-id=27598201]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598201; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598201']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ccd9bee86ef3397b3f591cf1471a5b58" } } $('.js-work-strip[data-work-id=27598201]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598201,"title":"Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo","internal_url":"https://www.academia.edu/27598201/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860863,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860863/thumbnails/1.jpg","file_name":"Benzene_and_its_phenolic_metabolites_pro20160807-1291-kihj6c.pdf","download_url":"https://www.academia.edu/attachments/47860863/download_file","bulk_download_file_name":"Benzene_and_its_phenolic_metabolites_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860863/Benzene_and_its_phenolic_metabolites_pro20160807-1291-kihj6c-libre.pdf?1470580425=\u0026response-content-disposition=attachment%3B+filename%3DBenzene_and_its_phenolic_metabolites_pro.pdf\u0026Expires=1739736096\u0026Signature=fduUBXISTZBH63MOooVfk6DolxXzIpfuewR83TRgfWaKDttfXJmhnKNm0-33aCIHv0vptHioswBmPOkucR0AD7-Sw9lD4s2~BpatqyHBhCrY4TwMA20f-o8lPahsYjcj3Q5caPeg2~R1eiB0-n2QZDBVxhGdq9~7NkyUSzWb7HNzT6JkWJ2fDQwPK0TZUnHffZvJU-mhntIfwCElVXKXJumDwuwsOGS2imaHdYuvCQTTuvrKhoTGsJt-YYDQfhf8GXSkw9Vejq-DxVUqxxCeJGil4c1bi2ZnY6Wawonq2qH~g9aWTcHmduKlXBaqT5qP9urJ~EIumfxEo5Im1uSXNA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598200"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598200/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity"><img alt="Research paper thumbnail of Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/47860867/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598200/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity">Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monoox...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monooxygenase to phenol. Further hydroxylation of phenol by cytochrome P-450 monooxygenase results in the formation of mainly hydroquinone, which accumulates in the bone marrow. Bone marrow contains high levels of myeloperoxidase. Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase. N o hydroquinone formation was detected in the absence of myeloperoxidase. At low concentrations superoxide disniutase stimulated, but at high concentrations inhibited. the conversion of phenol to hydroquinone. The inhibitory effect at high superoxide dismutase concentrations indicates that the active hydroxylating species of myeloperoxidase is not derived from its interaction with hydrogen peroxide. Furthermore, catalase a hydrogen peroxide scavenger, was found to have no significant effect on hydroxylation of phenol to hydroquinone. supporting the lack of hydrogen peroxide involvement. Mannitol (a hydroxyl radical scavenger) was found to have no inhibitory effect, but histidine (a singlet oxygen scavenger) inhibited hydroquinone formation. Based on these results we postulate that a myeloperoxidasesuperoxide complex spontaneously rearranges to generate singlet oxygen and that this singlet oxygen is responsible for phenol hydroxylation to hydroquinone. These results also suggest that myeloperoxidase dependent hydroquinone formation could play a role in the production and accumulation of hydroquinone in bone marrow. the target organ of benzene-induced myelotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6e6036422d38faaa48b5a40c5c01571c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860867,"asset_id":27598200,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860867/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598200"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598200"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598200; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598199"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598199/T%CE%B2R_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele"><img alt="Research paper thumbnail of TβR-I(6A) Is a Candidate Tumor Susceptibility Allele" class="work-thumbnail" src="https://attachments.academia-assets.com/47860862/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598199/T%CE%B2R_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele">TβR-I(6A) Is a Candidate Tumor Susceptibility Allele</a></div><div class="wp-workCard_item"><span>Cancer Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have previously described a type I transforming growth factor (TGF)-␤ receptor (T␤R-I) polymor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have previously described a type I transforming growth factor (TGF)-␤ receptor (T␤R-I) polymorphic allele, T␤R-I(6A), that has a deletion of three alanines from a nine-alanine stretch. We observed a higher than expected number of T␤R-I(6A) homozygotes among tumor and nontumor DNA from patients with a diagnosis of cancer. To test the hypothesis that T␤R-I(6A) homozygosity is associated with cancer, we performed a case-control study in patients with a diagnosis of cancer and matched healthy individuals with no history of cancer and who were identical in their gender and their geographical and ethnic background to determine the relative germ-line frequencies of this allele. We found nine T␤R-I(6A) homozygotes among 851 patients with cancer. In comparison, there were no T␤R-I(6A) homozygotes among 735 healthy volunteers (P < 0.01). We also observed an excess of T␤R-I(6A) heterozygotes in cancer cases compared to controls (14.6% versus 10.6%; P ‫؍‬ 0.02, Fisher's exact test). A subset analysis revealed that 4 of 112 patients with colorectal cancer were T␤R-I(6A) homozygotes (P < 0.01). Using mink lung epithelial cell lines devoid of T␤R-I, we established stably transfected T␤R-I and T␤R-I(6A) cell lines. We found that, compared to T␤R-I, T␤R-I(6A) was impaired as a mediator of TGF-␤ antiproliferative signals. We conclude that T␤R-I(6A) acts as a tumor susceptibility allele that may contribute to the development of cancer, especially colon cancer, by means of reduced TGF-␤-mediated growth inhibition. (J.M.). The abbreviations used are: TGF, transforming growth factor.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7426b7c5c9329828caac12935c578ca4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860862,"asset_id":27598199,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860862/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598199"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598199"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598199; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598199]").text(description); $(".js-view-count[data-work-id=27598199]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598199; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598199']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7426b7c5c9329828caac12935c578ca4" } } $('.js-work-strip[data-work-id=27598199]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598199,"title":"TβR-I(6A) Is a Candidate Tumor Susceptibility Allele","internal_url":"https://www.academia.edu/27598199/T%CE%B2R_I_6A_Is_a_Candidate_Tumor_Susceptibility_Allele","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860862/thumbnails/1.jpg","file_name":"5678.full.pdf","download_url":"https://www.academia.edu/attachments/47860862/download_file","bulk_download_file_name":"TR_I_6A_Is_a_Candidate_Tumor_Susceptibi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860862/5678.full-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DTR_I_6A_Is_a_Candidate_Tumor_Susceptibi.pdf\u0026Expires=1739736096\u0026Signature=EKxMLBAp8swQegCq~Wbk7-fhaX9720zDv7wCQWmmdImpZi0oMs5cC0Vv2VeDaF0NLnbrZuiPsZLGrwa0KWWk9JnqSs3uHmUATrbOAz5bFiS6Th2EogiVJ4lHDH~uq7HfV~RkLt~deE1rf9qd0jZ3Gp-V7IS8bl4etH-tge4QlPSDY~D6xnJN1RBUS5CTwxO~2wmYyHUSAgnjq-ctJu8CGNmy5MKhnvCRLZnsFZCPX2giWNCtRER-LezuaYPZPJgma2zGve4g96jY8iKPjjTK-GCS49K6gwwM3YHLO80j87Z7oS8zQBNXYuwHyHsByPaOtrOlxqrUDYf1evVZO3xPxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598198"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598198/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo"><img alt="Research paper thumbnail of Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/47860855/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598198/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo">Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is metabo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is metabolized by cytochrome P450 2E1 to various phenolic metabolites which accumulate in the bone marrow. Bone marrow contains high levels of myeloperoxidase which can catalyze the further metabolism of the phenolic metabolites to reactive free radical species. Redox cycling of these free radical species produces active oxygen. This active oxygen may damage cellular DNA (known as oxidative DNA damage) and induce genotoxic effects. Here we report the induction of oxidative DNA damage by benzene and its phenolic metabolites in HL60 cells in vitro and in the bone marrow of C57BL/6 x C3H F1 mice in vivo utilizing 8-hydroxy-2&#39;-deoxyguanosine as a marker. HL60 cells (a human leukemia cell line) contain high levels of myeloperoxidase and were used as an in vitro model system. Exposure of these cells to phenol, hydroquinone, and 1,2,4-benzenetriol resulted in an increased level of oxidative DNA dama...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65f575fa5206bc7c8150f49a91fce64b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860855,"asset_id":27598198,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860855/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598198"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598198"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598198; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598198]").text(description); $(".js-view-count[data-work-id=27598198]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598198; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598198']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65f575fa5206bc7c8150f49a91fce64b" } } $('.js-work-strip[data-work-id=27598198]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598198,"title":"Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo","internal_url":"https://www.academia.edu/27598198/Benzene_and_its_phenolic_metabolites_produce_oxidative_DNA_damage_in_HL60_cells_in_vitro_and_in_the_bone_marrow_in_vivo","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860855,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860855/thumbnails/1.jpg","file_name":"1023.pdf","download_url":"https://www.academia.edu/attachments/47860855/download_file","bulk_download_file_name":"Benzene_and_its_phenolic_metabolites_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860855/1023-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DBenzene_and_its_phenolic_metabolites_pro.pdf\u0026Expires=1739736096\u0026Signature=CKKyS-ypZ8k2Hftvk91890CZeQYNPI897Oi9B48aZKkrC26x1~tIKSLQ~rG4BuoaP31IxaHlAdxZgFPMW3eeQq7ltA-Bzsqld6bJpRXZILBJ27eP9coeHg0KJG1iSjvEPeLF8exSiMwZkAIR6dPLhEK2CoqZBYPWge99VP9KgZSPdXLCGRIac12xemDnZGm9Y3LPFYcD4~~0zDtPwnJH3Snobrd77tckjoz49oL-Rv9jZtmtquIxY5XWAWJUKYS63Xp9QyL-7hC9SlJv76sBxYT7fV8aUMrcXeGRCFJQTXtYTUkG4HA5CBFKCiBHKDqYo~vYPU3FT7W6dSxWOm3dsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598197"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598197/Effect_of_Phenol_and_Catechol_on_the_Kinetics_of_Human_Myeloperoxidase_Dependent_Hydroquinone_Metabolism"><img alt="Research paper thumbnail of Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598197/Effect_of_Phenol_and_Catechol_on_the_Kinetics_of_Human_Myeloperoxidase_Dependent_Hydroquinone_Metabolism">Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PremaKolachana">Prema Kolachana</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://manipal.academia.edu/SubrahmanyamVangala">Subrahmanyam Vangala</a></span></div><div class="wp-workCard_item"><span>Advances in Experimental Medicine and Biology</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598197"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598197"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598197; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598197]").text(description); $(".js-view-count[data-work-id=27598197]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598197; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598197']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598197]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598197,"title":"Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism","internal_url":"https://www.academia.edu/27598197/Effect_of_Phenol_and_Catechol_on_the_Kinetics_of_Human_Myeloperoxidase_Dependent_Hydroquinone_Metabolism","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598196/Induction_of_kinetochore_positive_micronuclei_in_human_lymphocytes_by_the_anti_fungal_drug_griseofulvin"><img alt="Research paper thumbnail of Induction of kinetochore-positive micronuclei in human lymphocytes by the anti-fungal drug griseofulvin" class="work-thumbnail" src="https://attachments.academia-assets.com/47860871/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598196/Induction_of_kinetochore_positive_micronuclei_in_human_lymphocytes_by_the_anti_fungal_drug_griseofulvin">Induction of kinetochore-positive micronuclei in human lymphocytes by the anti-fungal drug griseofulvin</a></div><div class="wp-workCard_item"><span>Mutation Research/Genetic Toxicology</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Griseofulvin (GF) is a widely used antifungal drug for the treatment of superficial dermatomycose...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Griseofulvin (GF) is a widely used antifungal drug for the treatment of superficial dermatomycoses. However, because GF is carcinogenic and teratogenic in animal models there is considerable concern regarding its clinical application. Further, it produces numerical chromosome aberrations in human lymphocytes and cell lines. There are conflicting reports on the ability of GF to induce structural chromosomal aberrations. Here, we show GF induces micronucleus formation both in isolated peripheral lymphocytes and lymphocytes from whole blood cultures. An antikinetochore antibody was used to distinguish micronuclei with acentric chromosome fragments (kinetochorenegative) and from those containing whole chromosomes (kinetochore-positive). The micronuclei formed were 99% kinetochore-positive in isolated lymphocytes. In addition, GF was able to alter the cell cycle kinetics of lymphocytes, thereby increasing the percentage of triploid cells. We conclude that GF is a strong aneuploidy-inducing agent in peripheral human lymphocytes and produces effects at concentrations which should be detectable in the blood of persons undergoing therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a4a05be571948964d592aa2bda7654f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860871,"asset_id":27598196,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860871/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598196"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598196"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598196; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598196]").text(description); $(".js-view-count[data-work-id=27598196]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598196; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598196']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1a4a05be571948964d592aa2bda7654f" } } $('.js-work-strip[data-work-id=27598196]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598196,"title":"Induction of kinetochore-positive micronuclei in human lymphocytes by the anti-fungal drug griseofulvin","internal_url":"https://www.academia.edu/27598196/Induction_of_kinetochore_positive_micronuclei_in_human_lymphocytes_by_the_anti_fungal_drug_griseofulvin","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860871,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860871/thumbnails/1.jpg","file_name":"Induction_of_kinetochore-positive_micron20160807-4245-xe2a60.pdf","download_url":"https://www.academia.edu/attachments/47860871/download_file","bulk_download_file_name":"Induction_of_kinetochore_positive_micron.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860871/Induction_of_kinetochore-positive_micron20160807-4245-xe2a60-libre.pdf?1470580427=\u0026response-content-disposition=attachment%3B+filename%3DInduction_of_kinetochore_positive_micron.pdf\u0026Expires=1739736096\u0026Signature=LmfTGkX2YHHsFZJw16tnsyYZYoD90EsQpzHHy6G1oD~CR-w5xKb70JSfCH53P07FUAUkwXc33fT8eH-ejFhr9hwxjG-Zby5Yntu7LMaXqenuk0yM7PKiG6wiu043JCGPNns27G1TgE-z-Yt4A6iXSJ9qZ9~uaIG8RoZorjCRuu8~m1rAenOwIIqoCIlzl0T7IY23fFj2X3-3kuGaF0tDJ7SBcV~YZsdKd05M3iMDtptv1rWAmd~Bjqln~0iv86HtHgoXaUs3BuU63sOelE2u8yoZ24LUt8Pi1AI-386EoQ64sNRgxywhboGFuZLsH52pY~mi1r~0vhOe99jfcIFdlg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598195"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598195/Rare_variants_of_ATM_and_risk_for_Hodgkins_disease_and_radiation_associated_breast_cancers"><img alt="Research paper thumbnail of Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598195/Rare_variants_of_ATM_and_risk_for_Hodgkins_disease_and_radiation_associated_breast_cancers">Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers</a></div><div class="wp-workCard_item"><span>Clinical cancer research : an official journal of the American Association for Cancer Research</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study, we first sought to evaluate whether individuals heterozygous for ATM mutations may have an increased susceptibility to radiation-induced breast cancer (BC) after treatment for Hodgkin&#39;s disease (HD). We next sought to determine the frequency of ATM variants in patients with Hodgkin&#39;s lymphoma, regardless of coexisting BC, compared with healthy volunteers. Full sequence analysis of ATM was performed on cDNA from peripheral blood lymphocytes from 37 cases of BC after therapeutic radiation therapy for HD and 27 comparison cases with HD and no BC treated during the same time period. The frequency of ATM variants was analyzed in the total group of 64 cases of HD and compared to allele frequencies in 128 ethnically matched controls from the same geographical region. No protein-truncating ATM mutations were observed in cases with HD with or without BC. Missense mutations were more frequent in the cohort with HD compared with patients with BC following HD (P = 0.02). ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598195"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598195"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598195; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598195]").text(description); $(".js-view-count[data-work-id=27598195]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598195; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598195']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598195]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598195,"title":"Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers","internal_url":"https://www.academia.edu/27598195/Rare_variants_of_ATM_and_risk_for_Hodgkins_disease_and_radiation_associated_breast_cancers","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598194/Frequency_of_CHEK2_1100delC_in_New_York_breast_cancer_cases_and_controls"><img alt="Research paper thumbnail of Frequency of CHEK2*1100delC in New York breast cancer cases and controls" class="work-thumbnail" src="https://attachments.academia-assets.com/47860857/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598194/Frequency_of_CHEK2_1100delC_in_New_York_breast_cancer_cases_and_controls">Frequency of CHEK2*1100delC in New York breast cancer cases and controls</a></div><div class="wp-workCard_item"><span>BMC medical genetics</span><span>, Jan 15, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The 1100delC CHEK2 allele has been associated with a 1.4-4.7 fold increased risk for breast cance...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The 1100delC CHEK2 allele has been associated with a 1.4-4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1-1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear. We genotyped 1665 healthy New York volunteers and 300 cases of breast cancer for the CHEK2*1100delC. The overall frequency of the 1100delC was 3/300 (1.0%) among all cases with either a family history of breast cancer (n = 192) or a personal history of breast cancer (n = 108, of which 46 were bilateral, 46 unilateral, and 16 were male breast cancer cases), compared to a frequency of 5/1665 (0.3%) in healthy controls (p = 0.1). There was no difference in allele frequency among Ashkenazi and non-Ashkenazi controls. The relatively low breast cancer penetrance of this allele, along with the low population frequency, will limit the clinical applicability of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d6ca7f710f2ecdff81a44c73457fca0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860857,"asset_id":27598194,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860857/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598194]").text(description); $(".js-view-count[data-work-id=27598194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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We observed a higher than expected number,of TbR-I(6A) homozygotes among tumor and nontumor DNA from patients with a diagnosis of cancer. To test the hypothesis that TbR-I(6A) homozygosity is associated with cancer,</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598192]").text(description); 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In intact animals, lesions (adducts) excised from DNA are transported from the cell through the circulation and excreted in urine. In bacteria, DNA adducts are excreted directly into the medium. In</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598191]").text(description); $(".js-view-count[data-work-id=27598191]").attr('title', description).tooltip(); 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598190/BLM_Heterozygosity_and_the_Risk_of_Colorectal_Cancer"><img alt="Research paper thumbnail of BLM Heterozygosity and the Risk of Colorectal Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/47860860/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598190/BLM_Heterozygosity_and_the_Risk_of_Colorectal_Cancer">BLM Heterozygosity and the Risk of Colorectal Cancer</a></div><div class="wp-workCard_item"><span>Science</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5325a72078a0593c7b0ea96f8d8e685c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860860,"asset_id":27598190,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860860/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598190]").text(description); $(".js-view-count[data-work-id=27598190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5325a72078a0593c7b0ea96f8d8e685c" } } $('.js-work-strip[data-work-id=27598190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598190,"title":"BLM Heterozygosity and the Risk of Colorectal Cancer","internal_url":"https://www.academia.edu/27598190/BLM_Heterozygosity_and_the_Risk_of_Colorectal_Cancer","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860860,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860860/thumbnails/1.jpg","file_name":"BLM_heterozygosity_and_the_risk_of_color20160807-31888-77oiyy.pdf","download_url":"https://www.academia.edu/attachments/47860860/download_file","bulk_download_file_name":"BLM_Heterozygosity_and_the_Risk_of_Color.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860860/BLM_heterozygosity_and_the_risk_of_color20160807-31888-77oiyy-libre.pdf?1470580425=\u0026response-content-disposition=attachment%3B+filename%3DBLM_Heterozygosity_and_the_Risk_of_Color.pdf\u0026Expires=1739736096\u0026Signature=Y8HV0fl3Ql63WENWf1XlYQhgFUMSPoWB0Syo0ddPgLjwRLH-XUL8piNNwVgPNgBCCquCfwS7YYOqAwvrFLQ4xf7J5zlQ7YnhafJPVeVzjcurz4jfJXHKrpaAkynr6mWxObB7a9vX3zwl3nTxKWyFHYwasLX76NW44rHXA~ratzASEhYeN4t5RgJgnYIii2yzjtGySFyzXc8w5GGkebpIixzIZZd6wY6iuYsCXbcOxHW3kGljS9AfgmFEeimVdXHSvCrqvbPqEzOT8t1wXCFNYxgfKFaElpVgMqt06TMn6J3p1IHevcBUucNdzVbo~iOf3BtM3pjOPFbq394K9~OWzg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598189/Benzene_induces_gene_duplicating_but_not_gene_inactivating_mutations_at_the_glycophorin_A_locus_in_exposed_humans"><img alt="Research paper thumbnail of Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans" class="work-thumbnail" src="https://attachments.academia-assets.com/47860861/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598189/Benzene_induces_gene_duplicating_but_not_gene_inactivating_mutations_at_the_glycophorin_A_locus_in_exposed_humans">Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. U...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple gene mutation assays. Benzene and its metabolites do, however, produce chromosomal damage in a variety of systems. Here, we have used the glycophorin A (GPA) gene loss mutation assay to evaluate the nature of DNA damage produced by benzene in 24 workers heavily exposed to benzene and 23 matched control individuals in Shanghai, China. The GPA assay identifies stem cell or precursor erythroid cell mutations expressed in peripheral erythrocytes of MN-heterozygous subjects, distinguishing the NN and N0 mutant variants. A significant increase in the NN GPA variant cell frequency (Vf) was found in benzene-exposed workers as compared with unexposed control individuals (mean ± SEM, 13.9 ± 1.7 per million cells vs. 7.4 + 1.1 per million cells in control individuals; P = 0.0002). In contrast, no significant difference existed between the two groups for the N0 Vf (9.1 + 0.9 vs. 8.8 + 1.8 per million cells; P = 0.21). Further, lifetime cumulative occupational exposure to benzene was associated with the NN Vf (P = 0.005) but not with the N0 Vf (P = 0.31), suggesting that NN mutations occur in longer-lived bone marrow stem cells. NN variants result from loss of the GPA M allele and duplication of the N allele, presumably through recombination mechanisms, whereas N0 variants arise from gene inactivation, presumably due to point mutations and deletions. Thus, these results suggest that benzene produces gene-duplicating mutations but does not produce gene-inactivating mutations at the GPA locus in bone marrow cells of humans exposed to high benzene levels. This finding is consistent with data on the genetic toxicology of benzene and its metabolites and adds further weight to the hypothesis that chromosome damage and mitotic recombination are important in benzene-induced leukemia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="51add9f3abb9601a51d9ccb7147c63b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860861,"asset_id":27598189,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860861/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598189; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "51add9f3abb9601a51d9ccb7147c63b8" } } $('.js-work-strip[data-work-id=27598189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598189,"title":"Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans","internal_url":"https://www.academia.edu/27598189/Benzene_induces_gene_duplicating_but_not_gene_inactivating_mutations_at_the_glycophorin_A_locus_in_exposed_humans","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860861,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860861/thumbnails/1.jpg","file_name":"Benzene_induces_gene-duplicating_but_not20160807-15684-cqyq0u.pdf","download_url":"https://www.academia.edu/attachments/47860861/download_file","bulk_download_file_name":"Benzene_induces_gene_duplicating_but_not.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860861/Benzene_induces_gene-duplicating_but_not20160807-15684-cqyq0u-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DBenzene_induces_gene_duplicating_but_not.pdf\u0026Expires=1739736096\u0026Signature=bsH6ZLq-oLtIWasXJ4iUZ98czZTD55NdwPh4wr0x0hrGmGVwG0fgBxdaIOJac9QTW7AnN8CeDr13aWO1c1HA3TMOq5jWT1x~zhQmKutMkf7DP-nH5lzJZ5eXsvUsQoy3YOVIHKJ--76O7LL0sM3Q26x7tOW33vXc5bssVI8PyvO7Q-vexQGfXYtwwvtPVBqUTbIXW1Y-hT3GujGt~ihigoDd7g9eQkq6ZiqiAPZSfmN7VgVvNuZSajdmVNwfe2ZtLji7dG12m1yZdCorm5vrYLiElD-~3LchFyBXKcV6MqZFtsnKJtroQYYeUGp0kHipK1mt2C9X76w~JnHUuprRew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598188/Genotoxicity_of_malathion_in_human_lymphocytes_assessed_using_the_micronucleus_assay_in_vitro_and_in_vivo_A_study_of_malathion_exposed_workers"><img alt="Research paper thumbnail of Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers" class="work-thumbnail" src="https://attachments.academia-assets.com/47860872/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598188/Genotoxicity_of_malathion_in_human_lymphocytes_assessed_using_the_micronucleus_assay_in_vitro_and_in_vivo_A_study_of_malathion_exposed_workers">Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers</a></div><div class="wp-workCard_item"><span>Mutation Research/Genetic Toxicology and Environmental Mutagenesis</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aerial application of malathion, a widely used organophosphate insecticide, has raised public...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aerial application of malathion, a widely used organophosphate insecticide, has raised public concerns about potential adverse health effects. We therefore studied micronucleus formation in human lymphocytes as a biomarker of genotoxicity both in vitro and in vivo. Lymphocytes were cultured either as whole blood or after Ficoll isolation and treated Ž with malathion in doses from 5 to 100 mgrml for 48 h. A significant increase in micronucleated cells 47.5r1000 versus . Ž . 16.0r1000 in DMSO control, p -0.001 was found in isolated lymphocytes at high dose levels 75-100 mgrml , Ž . concurrent with cytotoxicity and a strong inhibition of proliferation p -0.001 . Many of the treated cells also possessed multiple micronuclei. Antikinetochore-antibody staining revealed that the majority of malathion-induced micronuclei were kinetochore-negative. A significant dose-response was also observed in whole blood cultures, although the increase in Ž . micronucleated cells was lower than in isolated lymphocyte cultures p s 0.03 . When the same technique was applied to lymphocytes of 38 intermittently malathion-exposed workers involved in the Mediterranean Fruit Fly Eradication Program in California, no change in either proliferation or micronucleus level was observed compared with an unexposed control group. We conclude that malathion has a relatively low potential to cause chromosome damage in vitro, and corresponding doses are much higher than ones that even professional applicators are likely to be exposed to in vivo. The potential risk of chromosome damage for malathion exposure in vivo is therefore relatively low. More studies are needed to assess the possibility of interaction of malathion with other pesticides through combined exposure. $17.00 Copyright q 1997 Elsevier Science B.V. All rights reserved.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae5c91f4f69c22e2b92ce28a19647aad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860872,"asset_id":27598188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860872/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598188]").text(description); $(".js-view-count[data-work-id=27598188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ae5c91f4f69c22e2b92ce28a19647aad" } } $('.js-work-strip[data-work-id=27598188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598188,"title":"Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathion-exposed workers","internal_url":"https://www.academia.edu/27598188/Genotoxicity_of_malathion_in_human_lymphocytes_assessed_using_the_micronucleus_assay_in_vitro_and_in_vivo_A_study_of_malathion_exposed_workers","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860872,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860872/thumbnails/1.jpg","file_name":"Genotoxicity_of_malathion_in_human_lymph20160807-2864-1ox2dg9.pdf","download_url":"https://www.academia.edu/attachments/47860872/download_file","bulk_download_file_name":"Genotoxicity_of_malathion_in_human_lymph.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860872/Genotoxicity_of_malathion_in_human_lymph20160807-2864-1ox2dg9-libre.pdf?1470580426=\u0026response-content-disposition=attachment%3B+filename%3DGenotoxicity_of_malathion_in_human_lymph.pdf\u0026Expires=1739736096\u0026Signature=AOoGT2OUroKzpDI-gc477UBK36jL-Vh5PJLq37Z6ezABrMqQ9wp-0ST8Xem8JoMzRsvZ~U8nA6U8oRpT9F770ySjJtgowOEm6GF69ShBNiPk9vzfi1jg0KHVUEHExjeLjs3RcotSa8ioiQKXpbvBAPLdi3ztn~Y7vfRQd3WjUpfu4I2Nxph2PTvfgp92pdnwhBRKUCneiZ8WmiUWB6FFCbJRwFE4PvCa5Qs90lfV3jIyX0GpDXZxWWHI5hpqvaCywRTjmAo4sPIjtbS~I2QTWm8WentEHR4vkZC7jdT36dN1HXhbCDscn2nXRiYCNgmeAoCJo9Gi5ycmKF1Q2X0JeQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598186/A636P_is_associated_with_early_onset_colon_cancer_in_Ashkenazi_Jews"><img alt="Research paper thumbnail of A636P is associated with early-onset colon cancer in Ashkenazi Jews" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598186/A636P_is_associated_with_early_onset_colon_cancer_in_Ashkenazi_Jews">A636P is associated with early-onset colon cancer in Ashkenazi Jews</a></div><div class="wp-workCard_item"><span>Journal of the American College of Surgeons</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatou...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hereditary predisposition to colorectal cancer most often manifests itself as familial adenomatous polyposis from mutations of APC, or hereditary nonpolyposis colorectal cancer, resulting from mutations of MSH2, MLH1, MSH6, or other genes. Previously, we described a rare founder mutation MSH2*1906C &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; G in Ashkenazi Jews that was found in 8 of 1,345 individuals (0.6%) of Ashkenazi descent with colorectal cancer. This study seeks to characterize the proportion of individuals of Ashkenazi heritage with very early-onset colon cancer (diagnosed at age 40 or younger) that could be attributed to MSH2*1906C&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;G. We analyzed the carrier frequency of MSH2*1906C&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;G in paraffin samples from 31 Jewish patients age 40 or less, diagnosed with colorectal cancer at Memorial Sloan-Kettering and lymphocyte-derived DNA from 10 patients. We did not select for family history. Genotyping for MSH2*1906C&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;G was performed by polymerase chain reaction and restriction enzyme digestion methods. We detected the MSH2*1906G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;C mutation in 3 of the 41 samples (7.14%) of patients who had colorectal cancer diagnosed at age 40 or younger. This incidence is significantly greater than the 8 in 1,345 (0.6%) we observed for cases of colorectal cancer in Ashkenazi Jews not selected for age (p = 0.004). Although very rare in the population, MSH2*1906G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;C is found at an increased frequency in young Jewish patients with colorectal cancer. These results suggest that testing for the MSH2*1906G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;C mutation should be included in the evaluation of Ashkenazi Jewish individuals diagnosed with early-onset colon cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598186]").text(description); $(".js-view-count[data-work-id=27598186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598186,"title":"A636P is associated with early-onset colon cancer in Ashkenazi Jews","internal_url":"https://www.academia.edu/27598186/A636P_is_associated_with_early_onset_colon_cancer_in_Ashkenazi_Jews","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598185/Frequency_of_BRCA1_and_BRCA2_Mutations_in_Unselected_Ashkenazi_Jewish_Patients_With_Colorectal_Cancer"><img alt="Research paper thumbnail of Frequency of BRCA1 and BRCA2 Mutations in Unselected Ashkenazi Jewish Patients With Colorectal Cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598185/Frequency_of_BRCA1_and_BRCA2_Mutations_in_Unselected_Ashkenazi_Jewish_Patients_With_Colorectal_Cancer">Frequency of BRCA1 and BRCA2 Mutations in Unselected Ashkenazi Jewish Patients With Colorectal Cancer</a></div><div class="wp-workCard_item"><span>JNCI Journal of the National Cancer Institute</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mutations in BRCA1 and BRCA2 that predispose to breast and ovarian cancer are detected in approxi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mutations in BRCA1 and BRCA2 that predispose to breast and ovarian cancer are detected in approximately 2.5% of the Ashkenazi Jewish population. To explore whether carriers of Ashkenazi founder mutations in BRCA1 or BRCA2 have an increased risk for colorectal cancer, we screened 586 unselected Ashkenazi Jewish case patients with colorectal cancer for the three common founder mutations in BRCA1 and BRCA2. We identified six carriers (1.02%) among these case patients. After adjusting for age at diagnosis and sex by use of logistic regression analysis, we compared the incidence of carriers in this group of 586 case patients with that of 5012 Ashkenazi Jewish control subjects without a known history of colorectal cancer. The presence of a founder BRCA mutation was not associated with the risk of colorectal cancer (relative risk = 0.50, 95% confidence interval = 0.22 to 1.14). We thus recommend that counseling for colorectal cancer screening and prevention in individuals with BRCA mutations be based on the personal and family history of colorectal cancer or associated syndromic malignancies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598185]").text(description); $(".js-view-count[data-work-id=27598185]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598185']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598185]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598185,"title":"Frequency of BRCA1 and BRCA2 Mutations in Unselected Ashkenazi Jewish Patients With Colorectal Cancer","internal_url":"https://www.academia.edu/27598185/Frequency_of_BRCA1_and_BRCA2_Mutations_in_Unselected_Ashkenazi_Jewish_Patients_With_Colorectal_Cancer","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598184"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598184/MSH6_germline_mutations_are_rare_in_colorectal_cancer_families"><img alt="Research paper thumbnail of MSH6 germline mutations are rare in colorectal cancer families" class="work-thumbnail" src="https://attachments.academia-assets.com/47860870/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598184/MSH6_germline_mutations_are_rare_in_colorectal_cancer_families">MSH6 germline mutations are rare in colorectal cancer families</a></div><div class="wp-workCard_item"><span>International Journal of Cancer</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Germline mutations in MSH6 can cause HNPCC, which is associated with a tumor phenotype featuring ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Germline mutations in MSH6 can cause HNPCC, which is associated with a tumor phenotype featuring MSI. However, tumors arising in persons with disease-causing mutations of MSH6 may or may not exhibit MSI. We used D-HPLC to screen for germline mutations in the promoter region, the coding region and the 3-UTR of MSH6. Eighty-four families, enrolled on the basis of Amsterdam I and II criteria (HNPCC families) and less stringent criteria (HNPCC-like families), were tested for MMR gene mutations; 27 families had a disease-causing mutation in MLH1 or MSH2, and the remaining 57 families were tested for mutations in MSH6. Two protein-truncating mutations were identified in each of 2 families fulfilling the Amsterdam I criteria, being present in persons affected with early-onset colorectal cancers exhibiting MSI. Immunohistochemical analysis showed that expression of both MSH2 and MSH6 proteins was lost in the cancer cells of the 2 mutation carriers but only MSH6 protein expression was lost in 2 adenomatous polyps. A third possibly disease-causing mutation was found in a person affected with a tumor that did not exhibit MSI. In addition, we found 4 new polymorphisms and determined that neither of the 2 studied by association analysis conferred susceptibility to colorectal or endometrial cancer. Altogether, our results indicate that disease-causing germline mutations of MSH6 are rare in HNPCC and HNPCC-like families.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d343da684ee5ba4cf57c1c4aaf4959bc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860870,"asset_id":27598184,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860870/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598184"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598184"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598184; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598184]").text(description); $(".js-view-count[data-work-id=27598184]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598184; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598184']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d343da684ee5ba4cf57c1c4aaf4959bc" } } $('.js-work-strip[data-work-id=27598184]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598184,"title":"MSH6 germline mutations are rare in colorectal cancer families","internal_url":"https://www.academia.edu/27598184/MSH6_germline_mutations_are_rare_in_colorectal_cancer_families","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860870,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860870/thumbnails/1.jpg","file_name":"Peterlongo_P._et_al._MSH6_germline_mutat20160807-2860-139qzv1.pdf","download_url":"https://www.academia.edu/attachments/47860870/download_file","bulk_download_file_name":"MSH6_germline_mutations_are_rare_in_colo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860870/Peterlongo_P._et_al._MSH6_germline_mutat20160807-2860-139qzv1-libre.pdf?1470580425=\u0026response-content-disposition=attachment%3B+filename%3DMSH6_germline_mutations_are_rare_in_colo.pdf\u0026Expires=1739736096\u0026Signature=WNjptEzcTrPZGZReCw62O918rSxh4DgpoIlR-2CcV62-QIkl8j0KGwvbRD1veRmh4-A1OaOvVTYBx-o1JG5CFplwmqxFXeC~4fJCJ90WrNt9uRLNKCn5PuzReSgls9OKQ~ZCjQK3hOkoEq8ZhOnQ3ijakbQTz4kjz8fcO5z31A-rmI3eWHIdHayo5BEII19ciIgBa4tdsUNB6uQ-vJR1x-sbzWzm822Ubh~liK3j8vljhBYuaIqTzCtxH~GAP1KBY53NKa3-QG~R0u8~-2iiDWGN1A7vbVxUTVBqxc~vYZPpP9OJCFVe3jO~VPogk9tEjvl6iSWVeX4k1qZx8Sshag__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598183"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/27598183/Absence_of_post_transcriptional_RNA_modifications_ofBCL10_in_human_malignant_mesothelioma_and_colorectal_cancer"><img alt="Research paper thumbnail of Absence of post-transcriptional RNA modifications ofBCL10 in human malignant mesothelioma and colorectal cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/27598183/Absence_of_post_transcriptional_RNA_modifications_ofBCL10_in_human_malignant_mesothelioma_and_colorectal_cancer">Absence of post-transcriptional RNA modifications ofBCL10 in human malignant mesothelioma and colorectal cancer</a></div><div class="wp-workCard_item"><span>Genes, Chromosomes and Cancer</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The BCL10 gene, located at 1p22, has been implicated in a number of human malignancies, including...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The BCL10 gene, located at 1p22, has been implicated in a number of human malignancies, including malignant mesotheliomas (MMs) and colorectal carcinomas. Subsequent reports, however, have revealed an absence of BCL10 mutations in genomic DNA from such tumors. It has been proposed that some abnormalities of this gene may be found only in RNA and not in genomic DNA, suggesting that BCL10 may be mutated post-transcriptionally, rather than at the genomic level. To explore this possibility, we performed SSCP mutation analysis and direct sequencing of cDNA from 17 MM cell lines displaying LOH in 1p22, 12 MM tumor specimens, and 11 colon carcinoma cell lines. SSCP revealed several different band shifts in these samples. The nucleotide changes observed in the cDNA samples were also seen in matched genomic DNA and corresponded to known polymorphisms in the general population. Thus, we conclude the BCL10 mutations are absent at the cDNA level, and that this gene does not undergo &amp;quot;molecular misreading.&amp;quot; Since BCL10 also does not possess mutations at the genomic DNA level, it can be ruled out as a gene involved in the pathogenesis of MM and colorectal cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598183"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598183]").text(description); $(".js-view-count[data-work-id=27598183]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598183']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27598183]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598183,"title":"Absence of post-transcriptional RNA modifications ofBCL10 in human malignant mesothelioma and colorectal cancer","internal_url":"https://www.academia.edu/27598183/Absence_of_post_transcriptional_RNA_modifications_ofBCL10_in_human_malignant_mesothelioma_and_colorectal_cancer","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27598182"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27598182/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity"><img alt="Research paper thumbnail of Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/47860868/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27598182/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity">Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity</a></div><div class="wp-workCard_item"><span>Free Radical Research</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monoox...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Benzene, a known human rnyelotoxin and leukemogen is metabolized by liver cytochrome P-450 monooxygenase to phenol. Further hydroxylation of phenol by cytochrome P-450 monooxygenase results in the formation of mainly hydroquinone, which accumulates in the bone marrow. Bone marrow contains high levels of myeloperoxidase. Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase. N o hydroquinone formation was detected in the absence of myeloperoxidase. At low concentrations superoxide disniutase stimulated, but at high concentrations inhibited. the conversion of phenol to hydroquinone. The inhibitory effect at high superoxide dismutase concentrations indicates that the active hydroxylating species of myeloperoxidase is not derived from its interaction with hydrogen peroxide. Furthermore, catalase a hydrogen peroxide scavenger, was found to have no significant effect on hydroxylation of phenol to hydroquinone. supporting the lack of hydrogen peroxide involvement. Mannitol (a hydroxyl radical scavenger) was found to have no inhibitory effect, but histidine (a singlet oxygen scavenger) inhibited hydroquinone formation. Based on these results we postulate that a myeloperoxidasesuperoxide complex spontaneously rearranges to generate singlet oxygen and that this singlet oxygen is responsible for phenol hydroxylation to hydroquinone. These results also suggest that myeloperoxidase dependent hydroquinone formation could play a role in the production and accumulation of hydroquinone in bone marrow. the target organ of benzene-induced myelotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9588058525c8f3c3506184bd677008b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47860868,"asset_id":27598182,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47860868/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27598182"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27598182"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27598182; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27598182]").text(description); $(".js-view-count[data-work-id=27598182]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27598182; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27598182']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9588058525c8f3c3506184bd677008b8" } } $('.js-work-strip[data-work-id=27598182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27598182,"title":"Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity","internal_url":"https://www.academia.edu/27598182/Hydroxylation_of_Phenol_to_Hydroquinone_Catalyzed_by_A_Human_Myeloperoxidase_Superoxide_Complex_Possible_Implications_In_Benzene_Induced_Myelotoxicity","owner_id":51785298,"coauthors_can_edit":true,"owner":{"id":51785298,"first_name":"Prema","middle_initials":null,"last_name":"Kolachana","page_name":"PremaKolachana","domain_name":"independent","created_at":"2016-08-07T07:23:05.283-07:00","display_name":"Prema Kolachana","url":"https://independent.academia.edu/PremaKolachana"},"attachments":[{"id":47860868,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47860868/thumbnails/1.jpg","file_name":"Hydroxylation_of_Phenol_to_Hydroquinone_20160807-16752-1ir2t7.pdf","download_url":"https://www.academia.edu/attachments/47860868/download_file","bulk_download_file_name":"Hydroxylation_of_Phenol_to_Hydroquinone.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47860868/Hydroxylation_of_Phenol_to_Hydroquinone_20160807-16752-1ir2t7-libre.pdf?1470580428=\u0026response-content-disposition=attachment%3B+filename%3DHydroxylation_of_Phenol_to_Hydroquinone.pdf\u0026Expires=1739736096\u0026Signature=TUQ36Tjr1v9WmZmR4S~dtYr42-lF04Dq93iEVDP5-I4silklzdChPf-8WzjayHorf~Kja1IOGLjizb6GT0uYWgoF4OyeBJL0eIJChtuMv~dueTSIiWzgvtb6d5OmglDF56KfCWHOTyfYR5To9AoF5Z0bfDVDqngWXwtlkM7rbiF6lEIKVpnZ2SEDc5n3sFwwAXgLtLMxIB6M8AMtMLuC9dvSIkbtm0KyB1ZzH8JSrolc2oOhEXTJ4MXW0hiJNqAc5fu19j4~qdWvcJpsUDFGvmgk-hQzsAsJoSfRnKZn3TSxRXozVs00t7MfPdAYBDloosTfTKiUwUZOcBKrJj8vTQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); 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