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class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=zh.wikipedia.org&uselang=zh"><span>资助维基百科</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:%E5%88%9B%E5%BB%BA%E8%B4%A6%E6%88%B7&returnto=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0" title="我们推荐您创建账号并登录，但这不是强制性的"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>创建账号</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:%E7%94%A8%E6%88%B7%E7%99%BB%E5%BD%95&returnto=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0" title="建议你登录，尽管并非必须。[o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>登录</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> 未登录编辑者的页面 <a href="/wiki/Help:%E6%96%B0%E6%89%8B%E5%85%A5%E9%97%A8" aria-label="了解有关编辑的更多信息"><span>了解详情</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:%E6%88%91%E7%9A%84%E8%B4%A1%E7%8C%AE" title="来自此IP地址的编辑列表[y]" accesskey="y"><span>贡献</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:%E6%88%91%E7%9A%84%E8%AE%A8%E8%AE%BA%E9%A1%B5" title="对于来自此IP地址编辑的讨论[n]" accesskey="n"><span>讨论</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="站点"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="目录" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">目录</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">隐藏</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">序言</div> </a> </li> <li id="toc-摺疊與胺基酸序列之間的關係" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#摺疊與胺基酸序列之間的關係"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>摺疊與胺基酸序列之間的關係</span> </div> </a> <ul id="toc-摺疊與胺基酸序列之間的關係-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-自然狀態的阻擾" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#自然狀態的阻擾"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>自然狀態的阻擾</span> </div> </a> <ul id="toc-自然狀態的阻擾-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-外在因子對蛋白質摺疊的影響" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#外在因子對蛋白質摺疊的影響"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>外在因子對蛋白質摺疊的影響</span> </div> </a> <ul id="toc-外在因子對蛋白質摺疊的影響-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-折叠密码" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#折叠密码"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>折叠密码</span> </div> </a> <ul id="toc-折叠密码-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-蛋白质折叠的预测" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#蛋白质折叠的预测"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>蛋白质折叠的预测</span> </div> </a> <button aria-controls="toc-蛋白质折叠的预测-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>开关蛋白质折叠的预测子章节</span> </button> <ul id="toc-蛋白质折叠的预测-sublist" class="vector-toc-list"> <li id="toc-"假设法"" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#"假设法""> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>"假设法"</span> </div> </a> <ul id="toc-"假设法"-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-"规律法"" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#"规律法""> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>"规律法"</span> </div> </a> <ul id="toc-"规律法"-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-蛋白酶解（Proteolysis）" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#蛋白酶解（Proteolysis）"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>蛋白酶解（Proteolysis）</span> </div> </a> <ul id="toc-蛋白酶解（Proteolysis）-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-蛋白的不正確摺疊與神經退化症" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#蛋白的不正確摺疊與神經退化症"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>蛋白的不正確摺疊與神經退化症</span> </div> </a> <ul id="toc-蛋白的不正確摺疊與神經退化症-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-参考文献" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#参考文献"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>参考文献</span> </div> </a> <ul id="toc-参考文献-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-参閱" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#参閱"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>参閱</span> </div> </a> <ul id="toc-参閱-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-外部链接" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#外部链接"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>外部链接</span> </div> </a> <ul id="toc-外部链接-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="目录" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="开关目录" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">开关目录</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">蛋白质折叠</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="前往另一种语言写成的文章。37种语言可用" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-37" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">37种语言</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Prote%C3%AFen-invouing" title="Proteïen-invouing – 南非荷兰语" lang="af" hreflang="af" data-title="Proteïen-invouing" data-language-autonym="Afrikaans" data-language-local-name="南非荷兰语" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B7%D9%8A_%D8%A7%D9%84%D8%A8%D8%B1%D9%88%D8%AA%D9%8A%D9%86" title="طي البروتين – 阿拉伯语" lang="ar" hreflang="ar" data-title="طي البروتين" data-language-autonym="العربية" data-language-local-name="阿拉伯语" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Savijanje_proteina" title="Savijanje proteina – 波斯尼亚语" lang="bs" hreflang="bs" data-title="Savijanje proteina" data-language-autonym="Bosanski" data-language-local-name="波斯尼亚语" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Plegament_proteic" title="Plegament proteic – 加泰罗尼亚语" lang="ca" hreflang="ca" data-title="Plegament proteic" data-language-autonym="Català" data-language-local-name="加泰罗尼亚语" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Skl%C3%A1d%C3%A1n%C3%AD_protein%C5%AF" title="Skládání proteinů – 捷克语" lang="cs" hreflang="cs" data-title="Skládání proteinů" data-language-autonym="Čeština" data-language-local-name="捷克语" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Proteinfaltung" title="Proteinfaltung – 德语" lang="de" hreflang="de" data-title="Proteinfaltung" data-language-autonym="Deutsch" data-language-local-name="德语" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Protein_folding" title="Protein folding – 英语" lang="en" hreflang="en" data-title="Protein folding" data-language-autonym="English" data-language-local-name="英语" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Proteina_faldado" title="Proteina faldado – 世界语" lang="eo" hreflang="eo" data-title="Proteina faldado" data-language-autonym="Esperanto" data-language-local-name="世界语" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Plegamiento_de_prote%C3%ADnas" title="Plegamiento de proteínas – 西班牙语" lang="es" hreflang="es" data-title="Plegamiento de proteínas" data-language-autonym="Español" data-language-local-name="西班牙语" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Proteinen_tolespena" title="Proteinen tolespena – 巴斯克语" lang="eu" hreflang="eu" data-title="Proteinen tolespena" data-language-autonym="Euskara" data-language-local-name="巴斯克语" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AA%D8%A7%D8%B4%D8%AF%DA%AF%DB%8C_%D9%BE%D8%B1%D9%88%D8%AA%D8%A6%DB%8C%D9%86" title="تاشدگی پروتئین – 波斯语" lang="fa" hreflang="fa" data-title="تاشدگی پروتئین" data-language-autonym="فارسی" data-language-local-name="波斯语" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Proteiinilaskos" title="Proteiinilaskos – 芬兰语" lang="fi" hreflang="fi" data-title="Proteiinilaskos" data-language-autonym="Suomi" data-language-local-name="芬兰语" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Repliement_des_prot%C3%A9ines" title="Repliement des protéines – 法语" lang="fr" hreflang="fr" data-title="Repliement des protéines" data-language-autonym="Français" data-language-local-name="法语" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Pregamento_de_prote%C3%ADnas" title="Pregamento de proteínas – 加利西亚语" lang="gl" hreflang="gl" data-title="Pregamento de proteínas" data-language-autonym="Galego" data-language-local-name="加利西亚语" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A7%D7%99%D7%A4%D7%95%D7%9C_%D7%97%D7%9C%D7%91%D7%95%D7%A0%D7%99%D7%9D" title="קיפול חלבונים – 希伯来语" lang="he" hreflang="he" data-title="קיפול חלבונים" data-language-autonym="עברית" data-language-local-name="希伯来语" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%8D%D5%BA%D5%AB%D5%BF%D5%A1%D5%AF%D5%B8%D6%82%D6%81%D5%AB_%D6%86%D5%B8%D5%AC%D5%A4%D5%AB%D5%B6%D5%A3" title="Սպիտակուցի ֆոլդինգ – 亚美尼亚语" lang="hy" hreflang="hy" data-title="Սպիտակուցի ֆոլդինգ" data-language-autonym="Հայերեն" data-language-local-name="亚美尼亚语" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Pelipatan_protein" title="Pelipatan protein – 印度尼西亚语" lang="id" hreflang="id" data-title="Pelipatan protein" data-language-autonym="Bahasa Indonesia" data-language-local-name="印度尼西亚语" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Ripiegamento_delle_proteine" title="Ripiegamento delle proteine – 意大利语" lang="it" hreflang="it" data-title="Ripiegamento delle proteine" data-language-autonym="Italiano" data-language-local-name="意大利语" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%95%E3%82%A9%E3%83%BC%E3%83%AB%E3%83%87%E3%82%A3%E3%83%B3%E3%82%B0" title="フォールディング – 日语" lang="ja" hreflang="ja" data-title="フォールディング" data-language-autonym="日本語" data-language-local-name="日语" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%8B%A8%EB%B0%B1%EC%A7%88_%EC%A0%91%ED%9E%98" title="단백질 접힘 – 韩语" lang="ko" hreflang="ko" data-title="단백질 접힘" data-language-autonym="한국어" data-language-local-name="韩语" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%A3%D1%83%D1%80%D0%B3%D0%B8%D0%B9%D0%BD_%D0%BD%D1%83%D0%B3%D0%B0%D1%80%D0%B0%D0%BB%D1%82" title="Уургийн нугаралт – 蒙古语" lang="mn" hreflang="mn" data-title="Уургийн нугаралт" data-language-autonym="Монгол" data-language-local-name="蒙古语" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Eiwitvouwing" title="Eiwitvouwing – 荷兰语" lang="nl" hreflang="nl" data-title="Eiwitvouwing" data-language-autonym="Nederlands" data-language-local-name="荷兰语" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Zwijanie_bia%C5%82ka" title="Zwijanie białka – 波兰语" lang="pl" hreflang="pl" data-title="Zwijanie białka" data-language-autonym="Polski" data-language-local-name="波兰语" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Enovelamento_de_prote%C3%ADnas" title="Enovelamento de proteínas – 葡萄牙语" lang="pt" hreflang="pt" data-title="Enovelamento de proteínas" data-language-autonym="Português" data-language-local-name="葡萄牙语" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Plierea_proteinelor" title="Plierea proteinelor – 罗马尼亚语" lang="ro" hreflang="ro" data-title="Plierea proteinelor" data-language-autonym="Română" data-language-local-name="罗马尼亚语" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A4%D0%BE%D0%BB%D0%B4%D0%B8%D0%BD%D0%B3_%D0%B1%D0%B5%D0%BB%D0%BA%D0%B0" title="Фолдинг белка – 俄语" lang="ru" hreflang="ru" data-title="Фолдинг белка" data-language-autonym="Русский" data-language-local-name="俄语" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Proteinsko_savijanje" title="Proteinsko savijanje – 塞尔维亚-克罗地亚语" lang="sh" hreflang="sh" data-title="Proteinsko savijanje" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="塞尔维亚-克罗地亚语" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Protein_folding" title="Protein folding – Simple English" lang="en-simple" hreflang="en-simple" data-title="Protein folding" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Skladanie_bielkov%C3%ADn" title="Skladanie bielkovín – 斯洛伐克语" lang="sk" hreflang="sk" data-title="Skladanie bielkovín" data-language-autonym="Slovenčina" data-language-local-name="斯洛伐克语" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sq mw-list-item"><a href="https://sq.wikipedia.org/wiki/Palosja_e_proteinave" title="Palosja e proteinave – 阿尔巴尼亚语" lang="sq" hreflang="sq" data-title="Palosja e proteinave" data-language-autonym="Shqip" data-language-local-name="阿尔巴尼亚语" class="interlanguage-link-target"><span>Shqip</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Proteinsko_savijanje" title="Proteinsko savijanje – 塞尔维亚语" lang="sr" hreflang="sr" data-title="Proteinsko savijanje" data-language-autonym="Српски / srpski" data-language-local-name="塞尔维亚语" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Proteinveckning" title="Proteinveckning – 瑞典语" lang="sv" hreflang="sv" data-title="Proteinveckning" data-language-autonym="Svenska" data-language-local-name="瑞典语" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%AA%E0%AF%81%E0%AE%B0%E0%AE%A4%E0%AE%AE%E0%AF%8D_%E0%AE%AE%E0%AE%9F%E0%AE%BF%E0%AE%AA%E0%AF%8D%E0%AE%AA%E0%AE%9F%E0%AF%88%E0%AE%A4%E0%AE%B2%E0%AF%8D" title="புரதம் மடிப்படைதல் – 泰米尔语" lang="ta" hreflang="ta" data-title="புரதம் மடிப்படைதல்" data-language-autonym="தமிழ்" data-language-local-name="泰米尔语" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%81%E0%B8%B2%E0%B8%A3%E0%B8%A1%E0%B9%89%E0%B8%A7%E0%B8%99%E0%B8%9E%E0%B8%B1%E0%B8%9A%E0%B9%82%E0%B8%9B%E0%B8%A3%E0%B8%95%E0%B8%B5%E0%B8%99" title="การม้วนพับโปรตีน – 泰语" lang="th" hreflang="th" data-title="การม้วนพับโปรตีน" data-language-autonym="ไทย" data-language-local-name="泰语" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%97%D0%B3%D0%BE%D1%80%D1%82%D0%B0%D0%BD%D0%BD%D1%8F_%D0%B1%D1%96%D0%BB%D0%BA%D1%96%D0%B2" title="Згортання білків – 乌克兰语" lang="uk" hreflang="uk" data-title="Згортання білків" data-language-autonym="Українська" data-language-local-name="乌克兰语" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Oqsil_foldingi" title="Oqsil foldingi – 乌兹别克语" lang="uz" hreflang="uz" data-title="Oqsil foldingi" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="乌兹别克语" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Cu%E1%BB%99n_g%E1%BA%ADp_protein" title="Cuộn gập protein – 越南语" lang="vi" hreflang="vi" data-title="Cuộn gập protein" data-language-autonym="Tiếng Việt" data-language-local-name="越南语" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q847556#sitelinks-wikipedia" title="编辑跨语言链接" class="wbc-editpage">编辑链接</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="命名空间"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0" title="浏览条目正文[c]" accesskey="c"><span>条目</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0" rel="discussion" title="关于此页面的讨论[t]" accesskey="t"><span>讨论</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" 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typeof="mw:File"><a href="/wiki/File:Antistub.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Antistub.svg/44px-Antistub.svg.png" decoding="async" width="44" height="44" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Antistub.svg/66px-Antistub.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Antistub.svg/88px-Antistub.svg.png 2x" data-file-width="200" data-file-height="200" /></a></span></div></td><td class="mbox-text"><div class="mbox-text-span">此條目<b>需要擴充。</b><span class="hide-when-compact"></span> <small class="date-container"><i>(<span class="date">2007年9月26日</span>)</i></small><span class="hide-when-compact"><br /><small>请協助<a class="external text" href="https://zh.wikipedia.org/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit">改善这篇條目</a>，更進一步的信息可能會在<a href="/wiki/Talk:%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0" title="Talk:蛋白质折叠">討論頁</a>或<a href="/wiki/Wikipedia:%E6%89%A9%E5%85%85%E8%AF%B7%E6%B1%82" title="Wikipedia:扩充请求">扩充请求</a>中找到。请在擴充條目後將此模板移除。</small></span><span class="hide-when-compact"></span></div></td></tr></tbody></table> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Protein_folding.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a9/Protein_folding.png/300px-Protein_folding.png" decoding="async" width="300" height="133" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a9/Protein_folding.png/450px-Protein_folding.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a9/Protein_folding.png/600px-Protein_folding.png 2x" data-file-width="994" data-file-height="440" /></a><figcaption>蛋白质折叠前后</figcaption></figure> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Protein_structure.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/05/Protein_structure.png/300px-Protein_structure.png" decoding="async" width="300" height="225" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/05/Protein_structure.png/450px-Protein_structure.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/05/Protein_structure.png/600px-Protein_structure.png 2x" data-file-width="1344" data-file-height="1008" /></a><figcaption>蛋白质折叠结果</figcaption></figure> <style data-mw-deduplicate="TemplateStyles:r82655521">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:#f9f9f9;display:flow-root}.mw-parser-output .side-box-abovebelow,.mw-parser-output .side-box-text{padding:0.25em 0.9em}.mw-parser-output .side-box-image{padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .side-box-imageright{padding:2px 0.9em 2px 0;text-align:center}@media(min-width:500px){.mw-parser-output .side-box-flex{display:flex;align-items:center}.mw-parser-output .side-box-text{flex:1}}@media(min-width:720px){.mw-parser-output .side-box{width:238px}.mw-parser-output .side-box-right{clear:right;float:right;margin-left:1em}.mw-parser-output .side-box-left{margin-right:1em}}</style><div class="side-box side-box-right" style="width: 250px;"><style data-mw-deduplicate="TemplateStyles:r82655520">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style> <div class="side-box-flex"> <div class="side-box-text plainlist"><b><a href="/wiki/%E6%9C%AA%E8%A7%A3%E5%86%B3%E7%9A%84%E5%8C%96%E5%AD%A6%E9%97%AE%E9%A2%98" title="未解决的化学问题">未解決的化學問題</a>：</b>是否有可能僅透過序列和環境資訊預測<a href="/wiki/%E5%A4%9A%E8%82%BD" class="mw-redirect" title="多肽">多肽</a>序列的二級、三級和四級結構？还有<b>逆</b>蛋白质折叠<b>問題</b>：是否有可能設計一種多肽，在特定環境條件下使它采用给定的結構？</div> <div class="side-box-imageright"><span typeof="mw:File"><a href="/wiki/File:Question_mark2.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b0/Question_mark2.svg/40px-Question_mark2.svg.png" decoding="async" width="40" height="52" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b0/Question_mark2.svg/60px-Question_mark2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b0/Question_mark2.svg/80px-Question_mark2.svg.png 2x" data-file-width="71" data-file-height="92" /></a></span></div></div> </div> <p><b>蛋白质折叠</b>（英語：<span lang="en">Protein folding</span>）是<a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8" title="蛋白质">蛋白质</a>获得其功能性结构和构象的<b>物理过程</b>。通过这一物理过程，蛋白质从无规则卷曲折叠成特定的功能性三维结构<sup id="cite_ref-Alberts_1-0" class="reference"><a href="#cite_note-Alberts-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>。在从<a href="/wiki/MRNA" class="mw-redirect" title="MRNA">mRNA</a>序列翻译成线性的氨基酸链时，蛋白质都是以去折叠<a href="/wiki/%E5%A4%9A%E8%82%BD" class="mw-redirect" title="多肽">多肽</a>或无规则卷曲的形式存在。 </p><p>蛋白質的基本單位為<a href="/wiki/%E8%83%BA%E5%9F%BA%E9%85%B8" class="mw-redirect" title="胺基酸">胺基酸</a>，而蛋白質的<a href="/wiki/%E4%B8%80%E7%B4%9A%E7%B5%90%E6%A7%8B" class="mw-redirect" title="一級結構">一級結構</a>指的就是其胺基酸序列。蛋白質會由所含胺基酸<a href="/wiki/%E6%AE%98%E5%9F%BA" title="殘基">残基</a>的<a href="/wiki/%E8%A6%AA%E6%B0%B4%E6%80%A7" title="親水性">親水性</a>、<a href="/wiki/%E7%96%8F%E6%B0%B4%E6%80%A7" title="疏水性">疏水性</a>、帶正電、帶負電等特性通过残基间的相互作用而摺疊成一立體的<a href="/wiki/%E4%B8%89%E7%B4%9A%E7%B5%90%E6%A7%8B" class="mw-redirect" title="三級結構">三级結構</a>。 </p><p>根据<a href="/wiki/%E5%85%8B%E9%87%8C%E6%96%AF%E7%90%B4%C2%B7B%C2%B7%E5%AE%89%E8%8A%AC%E6%A3%AE" class="mw-redirect" title="克里斯琴·B·安芬森">克里斯琴·B·安芬森</a>（1972年的<a href="/wiki/%E8%AB%BE%E8%B2%9D%E7%88%BE%E5%8C%96%E5%AD%B8%E7%8D%8E" class="mw-redirect" title="諾貝爾化學獎">諾貝爾化學獎</a>得主）的研究，蛋白質可由加熱或置於某些<a href="/wiki/%E5%8C%96%E5%AD%B8" title="化學">化學</a>環境而<a href="/wiki/%E5%8F%98%E6%80%A7_(%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6)" title="变性 (生物化学)">变性</a>，三级结构解体；而當環境回復到原本的狀態時，蛋白質可於不到一秒的時間折疊至原先的立體結構，不論試驗幾次，蛋白質都僅此一種立體結構，於是安芬森提出一個結論：蛋白质分子的一级结构决定其立體结构（<span class="ilh-all" data-orig-title="安芬森法则" data-lang-code="en" data-lang-name="英语" data-foreign-title="Anfinsen's dogma"><span class="ilh-page"><a href="/w/index.php?title=%E5%AE%89%E8%8A%AC%E6%A3%AE%E6%B3%95%E5%88%99&action=edit&redlink=1" class="new" title="安芬森法则（页面不存在）">安芬森法则</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Anfinsen%27s_dogma" class="extiw" title="en:Anfinsen's dogma"><span lang="en" dir="auto">Anfinsen's dogma</span></a></span>）</span></span>）<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>。 </p><p>安芬森的研究结果非常重要，因為蛋白質的功能取決於其立體結構，而目前根据已知某基因序列可<a href="/wiki/%E7%BF%BB%E8%AF%91_(%E9%81%97%E4%BC%A0%E5%AD%A6)" class="mw-redirect" title="翻译 (遗传学)">翻译</a>获得对应蛋白质的胺基酸序列，即蛋白質的一級結構；如果從蛋白質的一級結構就能知道立體結構，那麼即可直接從<a href="/wiki/%E5%9F%BA%E5%9B%A0" title="基因">基因</a>推测其编码蛋白质所對應的生物学功能。虽然蛋白質可在短時間中從一級結構摺疊至立體結構，研究者卻無法在短時間中從胺基酸序列計算出蛋白质結構，甚至无法得到准确的三维结构。因此，研究蛋白质折叠的过程，可以说是破译<a class="mw-selflink-fragment" href="#折叠密码">折叠密码</a>的过程。 </p><p>目前蛋白质的再折叠依然遵从先使用<a href="/wiki/%E8%83%8D" title="胍">胍</a>或<a href="/wiki/%E8%84%B2" class="mw-redirect" title="脲">脲</a>变性，然后逐渐降低胍或者脲的浓度，也就是逐渐降低对蛋白质天然“回缩”能力的干扰。使其自然回到天然的最低能量状态。只是这个过程无法很好的控制肽链与肽链之间和肽链内部形成错误折叠的干扰。 </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="摺疊與胺基酸序列之間的關係"><span id=".E6.91.BA.E7.96.8A.E8.88.87.E8.83.BA.E5.9F.BA.E9.85.B8.E5.BA.8F.E5.88.97.E4.B9.8B.E9.96.93.E7.9A.84.E9.97.9C.E4.BF.82"></span>摺疊與胺基酸序列之間的關係</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=1" title="编辑章节：摺疊與胺基酸序列之間的關係"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>蛋白質的氨基酸序列決定於胺基酸的特性。蛋白質在生物合成的過程或是生物合成結束後進行折疊。蛋白質摺疊受到許多環境因素的影響，例如：溶劑（水、<a href="/wiki/%E8%84%82" class="mw-redirect" title="脂">脂类</a>雙層），鹽的濃度、<a href="/wiki/PH%E5%80%BC" title="PH值">pH值</a>、溫度。可能會出現輔助因子（cofactor）或伴侶因子（chaperon）。 </p><p>盡量減少疏水性蛋白暴露在水中，對蛋白質摺疊來說是一個很好的驅動力，分子內的氫鍵則可以穩定蛋白質結構。氫鍵強度與環境有關，因此在自然情況下，被包覆於疏水性核心的<a href="/wiki/%E6%B0%AB%E9%8D%B5" class="mw-redirect" title="氫鍵">氫鍵</a>和存在於充滿水環境下的氫鍵比起來，對於穩定性的貢獻較多。 </p><p>摺疊與<a href="/wiki/%E8%BD%89%E8%AD%AF" class="mw-redirect" title="轉譯">轉譯</a>是同時進行的（co - translationly），因此蛋白質的Ｃ端被<a href="/wiki/%E6%A0%B8%E7%B3%96%E9%AB%94" class="mw-redirect" title="核糖體">核糖體</a>（ribosome）製作出來，Ｎ端同時進行折疊的過程。特化的蛋白：伴侶因子可以使蛋白質不與其他蛋白作用（防止非特定區域結合）。最好的例子就是Gro-EL系統，能夠阻礙蛋白質非特定區域折疊的<a href="/wiki/%E7%90%83%E8%9B%8B%E7%99%BD" title="球蛋白">球蛋白</a>（globular protein）。在真核生物中，伴侶因子稱作熱休克蛋白（heat shock protein）。即使球蛋白可以在沒有任何輔助的情形下防止蛋白質非特定區域摺疊，伴侶因子的作用在細胞內部還是需要的。伴侶因子也可以防止蛋白質在細胞高溫或其他環境下產生錯誤的折疊或聚集。 </p><p>目前兩種蛋白質摺疊有兩種模型： </p> <ol><li>擴散碰撞模型（diffusion collision model），細胞核形成之時，蛋白質也同時形成二級結構，接著這些二級結構碰撞再一起並緊緊的包住。</li> <li>成核縮合模型（nucleation-condensation model），二級和三級結構同時形成。近期的學說顯示出某些蛋白具有以上的折疊現象。</li></ol> <p>大多數的科學家已能研究出許多相同的蛋白，將其聚合在一起。不論蛋白質是在惡劣的環境或是在天然狀態下，胺基酸摺疊過程大致上還是一樣的，通常會先摺疊成一般<a href="/wiki/%E4%BA%8C%E7%B4%9A%E7%B5%90%E6%A7%8B" title="二級結構">二級結構</a>（secondary structure）或超二級結構（supersecondary structure）,尤其是<a href="/wiki/%CE%91-%E8%9E%BA%E6%97%8B" class="mw-redirect" title="Α-螺旋">α-螺旋</a>結構（alpha heliex）和<a href="/wiki/%CE%92-%E6%91%BA%E7%96%8A" class="mw-redirect" title="Β-摺疊">β-摺疊</a>結構（beta sheet），之後再形成三級結構，若要形成四級結構則必須要和其他摺疊完成的結構進行組裝。一般的 α螺旋結構和β摺疊結構很快就可以快速折疊因為有分子內的氫鍵穩定其結構，此現象第一個發現者為<a href="/wiki/%E8%8E%B1%E7%BA%B3%E6%96%AF%C2%B7%E9%B2%8D%E6%9E%97" class="mw-redirect" title="莱纳斯·鲍林">莱纳斯·鲍林</a>（Linus Pauling）。蛋白質摺疊另外還有共價鍵結參與──兩個<a href="/wiki/%E5%8D%8A%E8%83%B1%E8%83%BA%E9%85%B8" class="mw-redirect" title="半胱胺酸">半胱胺酸</a>（cysteine）間形成的<a href="/wiki/%E9%9B%99%E7%A1%AB%E9%8D%B5" title="雙硫鍵">雙硫鍵</a> （disulfide bridges）或是金屬的聚集（metal clusters）。為了使能量達到穩定分子會形成中間產物：熔球（molten globule）型態。事實上，每個蛋白質的胺基酸序列都含有在蛋白質在特定狀態摺疊的訊息，這並不表示的胺基酸折疊方式都是一樣的。蛋白質折疊的構型也受到環境的影響，相同的蛋白在不同的環境下也會產生不同的折疊結構。摺疊是一個不需消耗能量的自發性過程，摺疊主要是由蛋白質的疏水作用主導，形成分子內氫鍵、<a href="/w/index.php?title=%E5%87%A1%E5%BE%B7%E7%93%A6%E5%8A%9B&action=edit&redlink=1" class="new" title="凡德瓦力（页面不存在）">凡德瓦力</a>。 </p> <div class="mw-heading mw-heading2"><h2 id="自然狀態的阻擾"><span id=".E8.87.AA.E7.84.B6.E7.8B.80.E6.85.8B.E7.9A.84.E9.98.BB.E6.93.BE"></span>自然狀態的阻擾</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=2" title="编辑章节：自然狀態的阻擾"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>蛋白質在某些情況下會形成有別於一般生物摺疊的摺疊結構，當環境的溫度超出或低於細胞所能承受的溫度時，會造成蛋白質的展開（unfold）或是<a href="/wiki/%E5%8F%98%E6%80%A7_(%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6)" title="变性 (生物化学)">變性</a>，這同時也是蛋白在沸水中變得不透明的原因。高濃度溶液、極端的酸鹼值、機械性影響以及其他會使蛋白質變性的溶劑都會造成類似的影響。但是，蛋白質的熱平衡常數相當高（即高溫才會產生變性的現象）。以<a href="/wiki/%E8%B6%85%E7%B4%9A%E5%97%9C%E7%86%B1%E8%8F%8C" class="mw-redirect" title="超級嗜熱菌">超級嗜熱菌</a>（hyperthermophilic bacteria）為例，其可在其高溫度122℃生存，其體內重要的蛋白質間的組合，在此溫度或更高溫時仍然能夠維持的相當穩定。 </p><p>一個已完全變性的蛋白質缺乏三級結構與四級結構，形成所謂的隨機螺旋（random coil），特定情況下蛋白質可以再次摺疊（refold），然而，蛋白質的變性往往是不可逆的。細胞有時候會產生<a href="/wiki/%E9%85%B5%E7%B4%A0" class="mw-redirect" title="酵素">酵素</a>──伴侶因子或<a href="/wiki/%E7%83%AD%E4%BC%91%E5%85%8B%E8%9B%8B%E7%99%BD" title="热休克蛋白">熱休克蛋白</a>來預防蛋白質在高溫中變性，伴侶因子或熱休克蛋白可以抵抗蛋白質的不正常摺疊與維持、協助正常摺疊。有些蛋白質因為彼此間不會有交互作用或其功能為幫助未摺疊或摺疊錯誤的蛋白質二度摺疊，因此伴侶因子不會阻止此類蛋白質摺疊。此現象亦可防止蛋白質沉澱以及防止蛋白質產生不規則形狀的結晶。 </p> <div class="mw-heading mw-heading2"><h2 id="外在因子對蛋白質摺疊的影響"><span id=".E5.A4.96.E5.9C.A8.E5.9B.A0.E5.AD.90.E5.B0.8D.E8.9B.8B.E7.99.BD.E8.B3.AA.E6.91.BA.E7.96.8A.E7.9A.84.E5.BD.B1.E9.9F.BF"></span>外在因子對蛋白質摺疊的影響</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=3" title="编辑章节：外在因子對蛋白質摺疊的影響"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>許多外在因子像是溫度、電場、磁場、分子的堆積，空間限制對於蛋白質的摺疊會有很大的影響。<sup id="cite_ref-Rizzuti_3-0" class="reference"><a href="#cite_note-Rizzuti-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> 外在因子若對蛋白質局部極小修飾，亦可引發蛋白質產生不一樣的摺疊方式。蛋白質摺疊對於蛋白質來說是一個很好的調整過程，不同原子間的氫鍵所提供的力量是必要的，疏水性蛋白間的疏水性作用包覆住疏水性殘基（residue）。 </p> <div class="mw-heading mw-heading2"><h2 id="折叠密码"><span id=".E6.8A.98.E5.8F.A0.E5.AF.86.E7.A0.81"></span>折叠密码</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=4" title="编辑章节：折叠密码"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>决定<a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8" title="蛋白质">蛋白质</a>如何折叠为特定的<a href="/wiki/%E4%B8%89%E7%BA%A7%E7%BB%93%E6%9E%84" class="mw-redirect" title="三级结构">三级结构</a>的因素称为折叠密码（英語：<span lang="en">folding code</span>）。肽链被翻译出来后，多条肽链能自行折叠成蛋白质。但其可能因为环境因素导致折叠错误，需要<a href="/wiki/%E5%88%86%E5%AD%90%E4%BC%B4%E4%BE%A3" title="分子伴侣">分子伴侣</a>正确折叠。<sup id="cite_ref-:0_4-0" class="reference"><a href="#cite_note-:0-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>因此折叠密码并不是决定蛋白质折叠的唯一因素。 </p> <div class="mw-heading mw-heading2"><h2 id="蛋白质折叠的预测"><span id=".E8.9B.8B.E7.99.BD.E8.B4.A8.E6.8A.98.E5.8F.A0.E7.9A.84.E9.A2.84.E6.B5.8B"></span>蛋白质折叠的预测</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=5" title="编辑章节：蛋白质折叠的预测"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r85100532">.mw-parser-output .hatnote{font-size:small}.mw-parser-output div.hatnote{padding-left:2em;margin-bottom:0.8em;margin-top:0.8em}.mw-parser-output .hatnote-notice-img::after{content:"\202f \202f \202f \202f "}.mw-parser-output .hatnote-notice-img-small::after{content:"\202f \202f "}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}body.skin-minerva .mw-parser-output .hatnote-notice-img,body.skin-minerva .mw-parser-output .hatnote-notice-img-small{display:none}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">主条目：<a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84%E9%A2%84%E6%B5%8B" title="蛋白质结构预测">蛋白质结构预测</a></div> <p>折叠密码需根据<a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8" title="蛋白质">蛋白质</a><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B3%AA%E4%B8%80%E7%B4%9A%E7%B5%90%E6%A7%8B" title="蛋白質一級結構">一级结构</a>（下文称“对象”）预测出<a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B3%AA%E4%B8%89%E7%B4%9A%E7%B5%90%E6%A7%8B" title="蛋白質三級結構">三级结构</a>来确定<sup id="cite_ref-:0_4-1" class="reference"><a href="#cite_note-:0-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>。以下为预测的两种方法。 </p> <div class="mw-heading mw-heading3"><h3 id=""假设法""><span id=".22.E5.81.87.E8.AE.BE.E6.B3.95.22"></span>"假设法"</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=6" title="编辑章节："假设法""><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>此法在假设<a class="mw-selflink selflink">折叠</a>后蛋白质的分子构象为<a href="/wiki/%E7%83%AD%E5%8A%9B%E5%AD%A6" title="热力学">热力学</a>最稳定，能量最低状态的基础下，使用<a href="/w/index.php?title=%E5%88%86%E5%AD%90%E5%8A%9B%E5%AD%A6%E7%9A%84%E8%83%BD%E9%87%8F%E6%9E%81%E5%B0%8F%E5%8C%96%E6%96%B9%E6%B3%95&action=edit&redlink=1" class="new" title="分子力学的能量极小化方法（页面不存在）">分子力学的能量极小化方法</a>，预测对象折叠后的结构。 </p> <div class="mw-heading mw-heading3"><h3 id=""规律法""><span id=".22.E8.A7.84.E5.BE.8B.E6.B3.95.22"></span>"规律法"</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=7" title="编辑章节："规律法""><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>此法先从已有的蛋白质一级与<a href="/wiki/%E4%B8%89%E7%BA%A7%E7%BB%93%E6%9E%84" class="mw-redirect" title="三级结构">三维</a>结构之关系找到规律，再用该规律推测出对象折叠后的结构。 </p> <div class="mw-heading mw-heading2"><h2 id="蛋白酶解（Proteolysis）"><span id=".E8.9B.8B.E7.99.BD.E9.85.B6.E8.A7.A3.EF.BC.88Proteolysis.EF.BC.89"></span>蛋白酶解（Proteolysis）</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=8" title="编辑章节：蛋白酶解（Proteolysis）"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/%E8%9B%8B%E7%99%BD%E9%85%B6%E8%A7%A3" title="蛋白酶解">蛋白酶解</a>經常用於探測出在廣泛的溶液情況中（有許多影響因子）分離出沒有被摺疊的蛋白質。<span class="ilh-all" data-orig-title="快速並行蛋白酶解" data-lang-code="en" data-lang-name="英语" data-foreign-title="Fast parallel proteolysis"><span class="ilh-page"><a href="/w/index.php?title=%E5%BF%AB%E9%80%9F%E4%B8%A6%E8%A1%8C%E8%9B%8B%E7%99%BD%E9%85%B6%E8%A7%A3&action=edit&redlink=1" class="new" title="快速並行蛋白酶解（页面不存在）">快速並行蛋白酶解</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Fast_parallel_proteolysis" class="extiw" title="en:Fast parallel proteolysis"><span lang="en" dir="auto">Fast parallel proteolysis</span></a></span>）</span></span>便是一個很好的例子。 </p> <div class="mw-heading mw-heading2"><h2 id="蛋白的不正確摺疊與神經退化症"><span id=".E8.9B.8B.E7.99.BD.E7.9A.84.E4.B8.8D.E6.AD.A3.E7.A2.BA.E6.91.BA.E7.96.8A.E8.88.87.E7.A5.9E.E7.B6.93.E9.80.80.E5.8C.96.E7.97.87"></span>蛋白的不正確摺疊與神經退化症</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=9" title="编辑章节：蛋白的不正確摺疊與神經退化症"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r85100532"><div role="note" class="hatnote navigation-not-searchable">主条目：<a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%9E%84%E8%B1%A1%E7%97%85" title="蛋白质构象病">蛋白质构象病</a></div> <p>有些不正常的蛋白聚集與許多疾病相關。 </p><p><a href="/wiki/%E6%9C%8A%E6%AF%92%E9%AB%94" title="朊毒體">朊毒體</a>相關的例如：<a href="/wiki/%E5%85%8B%E9%9B%85%E4%BA%8C%E6%B0%8F%E7%97%87" class="mw-redirect" title="克雅二氏症">克雅二氏症</a>（Creutzfeldt-Jakob disease），又稱作海綿狀腦症（bovine spongiform encephalopathy）。又如<a href="/wiki/%E7%89%9B%E8%85%A6%E6%B5%B7%E7%B6%BF%E7%8B%80%E7%97%85%E8%AE%8A" title="牛腦海綿狀病變">牛腦海綿狀病變</a>。 </p><p><a href="/wiki/%E9%A1%9E%E6%BE%B1%E7%B2%89%E8%9B%8B%E7%99%BD" title="類澱粉蛋白">類澱粉蛋白</a>相關的疾病例如：<a href="/wiki/%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%97%87" class="mw-redirect" title="阿茲海默症">阿茲海默症</a>（Alzheimer's disease）、家族性澱粉樣蛋白心肌病（familial amyloid cardiomyopathy）以及多發性神經病變（polyneuropathy），還有細胞質（包漿）內聚集的疾病，例如：<a href="/wiki/%E4%BA%A8%E4%B8%81%E9%A0%93%E8%88%9E%E8%B9%88%E7%97%87" title="亨丁頓舞蹈症">亨丁頓舞蹈症</a>（Huntington's disease）及<a href="/wiki/%E5%B8%95%E9%87%91%E6%A3%AE%E6%B0%8F%E7%97%87" class="mw-redirect" title="帕金森氏症">帕金森氏症</a>（Parkinson's disease）。這些退化性的疾病起因皆與蛋白質的聚集並摺疊錯誤使其不溶於水有關，胞外聚集或包裹在胞內形成交叉β折疊澱粉樣纖維（cross-beta sheet amyloid fibrils）。截至目前並不完全清楚這些不正常的蛋白質聚集現象是造成蛋白質失衡的主因還是只是蛋白質失衡所產生的反應。 </p> <div class="mw-heading mw-heading2"><h2 id="参考文献"><span id=".E5.8F.82.E8.80.83.E6.96.87.E7.8C.AE"></span>参考文献</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=10" title="编辑章节：参考文献"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist columns references-column-count references-column-count-2" style="-moz-column-count: 2; -webkit-column-count: 2; column-count: 2; list-style-type: decimal;"> <ol class="references"> <li id="cite_note-Alberts-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Alberts_1-0">^</a></b></span> <span class="reference-text"><cite class="citation book"><a href="/w/index.php?title=Bruce_Alberts&action=edit&redlink=1" class="new" title="Bruce Alberts（页面不存在）">Alberts, Bruce</a>; Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walters. <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=books&doptcmdl=GenBookHL&term=mboc4%5Bbook%5D+AND+372270%5Buid%5D&rid=mboc4.section.388">The Shape and Structure of Proteins</a>. Molecular Biology of the Cell; Fourth Edition. New York and London: Garland Science. 2002. <a href="/wiki/Special:%E7%BD%91%E7%BB%9C%E4%B9%A6%E6%BA%90/0-8153-3218-1" title="Special:网络书源/0-8153-3218-1"><span title="国际标准书号">ISBN</span> 0-8153-3218-1</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&rft.atitle=The+Shape+and+Structure+of+Proteins&rft.aufirst=Bruce&rft.aulast=Alberts&rft.btitle=Molecular+Biology+of+the+Cell%3B+Fourth+Edition&rft.date=2002&rft.genre=bookitem&rft.isbn=0-8153-3218-1&rft.place=New+York+and+London&rft.pub=Garland+Science&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DSearch%26db%3Dbooks%26doptcmdl%3DGenBookHL%26term%3Dmboc4%255Bbook%255D%2BAND%2B372270%255Buid%255D%26rid%3Dmboc4.section.388&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span> <span style="display:none;font-size:100%" class="error citation-comment">引文使用过时参数<code style="color:inherit; border:inherit; padding:inherit;">coauthors</code> (<a href="/wiki/Help:%E5%BC%95%E6%96%87%E6%A0%BC%E5%BC%8F1%E9%94%99%E8%AF%AF#deprecated_params" title="Help:引文格式1错误">帮助</a>)</span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><cite class="citation journal">Anfinsen, C. <a rel="nofollow" class="external text" href="https://archive.org/details/sim_biochemical-journal_1972-07_128_4/page/737">The formation and stabilization of protein structure</a>. Biochem. J. 1972, <b>128</b> (4): 737–49. <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1173893"><span title="公共医学中心">PMC 1173893</span></a> <span typeof="mw:File"><span title="可免费查阅"><img alt="可免费查阅" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>. <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/4565129"><span title="公共医学识别码">PMID 4565129</span></a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&rft.atitle=The+formation+and+stabilization+of+protein+structure&rft.au=Anfinsen%2C+C.&rft.date=1972&rft.genre=article&rft.issue=4&rft.jtitle=Biochem.+J.&rft.pages=737-49&rft.volume=128&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1173893&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_biochemical-journal_1972-07_128_4%2Fpage%2F737&rft_id=info%3Apmid%2F4565129&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-Rizzuti-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-Rizzuti_3-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Rizzuti, B., and Daggett, V. Using simulations to provide the framework for experimental protein folding studies. Arch. Biochem. Biophys. 2013, <b>531</b> (1-2): 128–135. <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/23266569"><span title="公共医学识别码">PMID 23266569</span></a>. <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.abb.2012.12.015"><span title="數位物件識別號">doi:10.1016/j.abb.2012.12.015</span></a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&rft.atitle=Using+simulations+to+provide+the+framework+for+experimental+protein+folding+studies&rft.au=Rizzuti%2C+B.%2C+and+Daggett%2C+V.&rft.date=2013&rft.genre=article&rft.issue=1-2&rft.jtitle=Arch.+Biochem.+Biophys.&rft.pages=128-135&rft.volume=531&rft_id=info%3Adoi%2F10.1016%2Fj.abb.2012.12.015&rft_id=info%3Apmid%2F23266569&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-:0-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_4-0"><sup><b>4.0</b></sup></a> <a href="#cite_ref-:0_4-1"><sup><b>4.1</b></sup></a></span> <span class="reference-text"><cite class="citation web"><a rel="nofollow" class="external text" href="https://www.ixueshu.com/document/1765083565b1cd14cbb2b55a9d0677f9318947a18e7f9386.html">蛋白质折叠与“折叠病”和“第二遗传密码”_爱学术</a>. www.ixueshu.com. <span class="reference-accessdate"> [<span class="nowrap">2020-07-02</span>]</span>. （原始内容<a rel="nofollow" class="external text" href="https://web.archive.org/web/20210210114834/https://www.ixueshu.com/document/1765083565b1cd14cbb2b55a9d0677f9318947a18e7f9386.html">存档</a>于2021-02-10）.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&rft.atitle=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0%E4%B8%8E%E2%80%9C%E6%8A%98%E5%8F%A0%E7%97%85%E2%80%9D%E5%92%8C%E2%80%9C%E7%AC%AC%E4%BA%8C%E9%81%97%E4%BC%A0%E5%AF%86%E7%A0%81%E2%80%9D_%E7%88%B1%E5%AD%A6%E6%9C%AF&rft.genre=unknown&rft.jtitle=www.ixueshu.com&rft_id=https%3A%2F%2Fwww.ixueshu.com%2Fdocument%2F1765083565b1cd14cbb2b55a9d0677f9318947a18e7f9386.html&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="参閱"><span id=".E5.8F.82.E9.96.B1"></span>参閱</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=11" title="编辑章节：参閱"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <div role="navigation" aria-label="Portals" class="noprint portal plainlist tright" style="margin:0.5em 0 0.5em 1em;border:solid #aaa 1px"> <ul style="display:table;box-sizing:border-box;padding:0.1em;max-width:175px;background:var(--background-color-base,#f9f9f9);font-size:85%;line-height:110%;font-weight:bold"> <li style="display:table-row"><span style="display:table-cell;padding:0.2em;vertical-align:middle;text-align:center"><span class="noviewer" typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Portal-puzzle.svg/32px-Portal-puzzle.svg.png" decoding="async" width="32" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Portal-puzzle.svg/48px-Portal-puzzle.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Portal-puzzle.svg/64px-Portal-puzzle.svg.png 2x" data-file-width="32" data-file-height="28" /></span></span></span><span style="display:table-cell;padding:0.2em 0.2em 0.2em 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data-file-height="600" /></a></span></span><span style="display:table-cell;padding:0.2em 0.2em 0.2em 0.3em;vertical-align:middle"><a href="/wiki/Portal:%E7%89%A9%E7%90%86%E5%AD%A6" title="Portal:物理学">物理学主题</a></span></li></ul></div> <style data-mw-deduplicate="TemplateStyles:r79074265">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="div-col" style="column-count:2; column-width:auto;"> <ul><li><a href="/wiki/%E7%BB%93%E6%9E%84%E5%9F%9F" 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title="蛋白质构象病">蛋白质构象病</a></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="外部链接"><span id=".E5.A4.96.E9.83.A8.E9.93.BE.E6.8E.A5"></span>外部链接</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%8A%98%E5%8F%A0&action=edit&section=12" title="编辑章节：外部链接"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><span style="font-family: sans-serif; cursor: default; color:var(--color-subtle, #54595d); font-size: 0.8em; bottom: 0.1em; font-weight: bold;" title="英語">（英文）</span><a rel="nofollow" class="external text" href="http://www.nature.com/horizon/proteinfolding/background/importance.html">关于蛋白质折叠的介绍</a> （<a rel="nofollow" class="external text" href="//web.archive.org/web/20200713212703/http://www.nature.com/horizon/proteinfolding/background/importance.html">页面存档备份</a>，存于<a href="/wiki/%E4%BA%92%E8%81%94%E7%BD%91%E6%A1%A3%E6%A1%88%E9%A6%86" title="互联网档案馆">互联网档案馆</a>）</li> <li><a class="external free" href="https://en.wikipedia.org/wiki/Fast_parallel_proteolysis_(FASTpp)">http://en.wikipedia.org/wiki/Fast_parallel_proteolysis_(FASTpp)</a> （<a rel="nofollow" class="external text" href="//web.archive.org/web/20210210114842/http://en.wikipedia.org/wiki/Fast_parallel_proteolysis_(FASTpp)">页面存档备份</a>，存于<a href="/wiki/%E4%BA%92%E8%81%94%E7%BD%91%E6%A1%A3%E6%A1%88%E9%A6%86" title="互联网档案馆">互联网档案馆</a>）</li></ul> <div style="clear: both; height: 1em"></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r84265675">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist 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style="width:1%">全α型折叠</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="螺旋束" data-lang-code="en" data-lang-name="英语" data-foreign-title="Helix bundle"><span class="ilh-page"><a href="/w/index.php?title=%E8%9E%BA%E6%97%8B%E6%9D%9F&action=edit&redlink=1" class="new" title="螺旋束（页面不存在）">螺旋束</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Helix_bundle" class="extiw" title="en:Helix bundle"><span lang="en" dir="auto">Helix bundle</span></a></span>）</span></span></li> <li><a href="/wiki/%E7%8F%A0%E8%9B%8B%E7%99%BD" title="珠蛋白">珠蛋白摺疊</a></li> <li><a href="/wiki/%E5%90%8C%E6%BA%90%E6%A1%86" title="同源框">同源框折叠</a></li> <li><span class="ilh-all" data-orig-title="α螺线管" data-lang-code="en" data-lang-name="英语" data-foreign-title="Alpha solenoid"><span class="ilh-page"><a href="/w/index.php?title=%CE%91%E8%9E%BA%E7%BA%BF%E7%AE%A1&action=edit&redlink=1" class="new" title="Α螺线管（页面不存在）">α螺线管</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Alpha_solenoid" class="extiw" title="en:Alpha solenoid"><span lang="en" dir="auto">Alpha solenoid</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">全β型折叠</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="免疫球蛋白折叠" data-lang-code="en" data-lang-name="英语" data-foreign-title="Immunoglobulin domain"><span class="ilh-page"><a href="/w/index.php?title=%E5%85%8D%E7%96%AB%E7%90%83%E8%9B%8B%E7%99%BD%E6%8A%98%E5%8F%A0&action=edit&redlink=1" class="new" title="免疫球蛋白折叠（页面不存在）">免疫球蛋白折叠</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Immunoglobulin_domain" class="extiw" title="en:Immunoglobulin domain"><span lang="en" dir="auto">Immunoglobulin domain</span></a></span>）</span></span></li> <li><a href="/wiki/%CE%92%E6%A1%B6%E7%8A%B6%E7%BB%93%E6%9E%84" title="Β桶状结构">β桶</a></li> <li><span class="ilh-all" data-orig-title="β-螺旋桨结构域" data-lang-code="en" data-lang-name="英语" data-foreign-title="Beta-propeller"><span class="ilh-page"><a href="/w/index.php?title=%CE%92-%E8%9E%BA%E6%97%8B%E6%A1%A8%E7%BB%93%E6%9E%84%E5%9F%9F&action=edit&redlink=1" class="new" title="Β-螺旋桨结构域（页面不存在）">β-螺旋桨结构域</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Beta-propeller" class="extiw" title="en:Beta-propeller"><span lang="en" dir="auto">Beta-propeller</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">α/β型折叠</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="磷酸丙糖异构酶桶" data-lang-code="en" data-lang-name="英语" data-foreign-title="TIM barrel"><span class="ilh-page"><a href="/w/index.php?title=%E7%A3%B7%E9%85%B8%E4%B8%99%E7%B3%96%E5%BC%82%E6%9E%84%E9%85%B6%E6%A1%B6&action=edit&redlink=1" class="new" title="磷酸丙糖异构酶桶（页面不存在）">TIM桶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/TIM_barrel" class="extiw" title="en:TIM barrel"><span lang="en" dir="auto">TIM barrel</span></a></span>）</span></span></li> <li><a href="/wiki/%E7%BD%97%E6%96%AF%E6%9B%BC%E6%8A%98%E5%8F%A0" title="罗斯曼折叠">罗斯曼折叠</a></li> <li><a href="/wiki/%E5%AF%8C%E4%BA%AE%E6%B0%A8%E9%85%B8%E9%87%8D%E5%A4%8D" title="富亮氨酸重复">富亮氨酸重复</a></li> <li><span class="ilh-all" data-orig-title="黄素氧化还原蛋白折叠" data-lang-code="en" data-lang-name="英语" data-foreign-title="Flavodoxin fold"><span class="ilh-page"><a href="/w/index.php?title=%E9%BB%84%E7%B4%A0%E6%B0%A7%E5%8C%96%E8%BF%98%E5%8E%9F%E8%9B%8B%E7%99%BD%E6%8A%98%E5%8F%A0&action=edit&redlink=1" class="new" title="黄素氧化还原蛋白折叠（页面不存在）">黄素氧化还原蛋白折叠</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Flavodoxin_fold" class="extiw" title="en:Flavodoxin fold"><span lang="en" dir="auto">Flavodoxin fold</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="硫氧化还原蛋白折叠" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thioredoxin fold"><span class="ilh-page"><a href="/w/index.php?title=%E7%A1%AB%E6%B0%A7%E5%8C%96%E8%BF%98%E5%8E%9F%E8%9B%8B%E7%99%BD%E6%8A%98%E5%8F%A0&action=edit&redlink=1" class="new" title="硫氧化还原蛋白折叠（页面不存在）">硫氧化还原蛋白折叠</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thioredoxin_fold" class="extiw" title="en:Thioredoxin fold"><span lang="en" dir="auto">Thioredoxin fold</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="三叶形纽结折叠" data-lang-code="en" data-lang-name="英语" data-foreign-title="Trefoil knot fold"><span class="ilh-page"><a href="/w/index.php?title=%E4%B8%89%E5%8F%B6%E5%BD%A2%E7%BA%BD%E7%BB%93%E6%8A%98%E5%8F%A0&action=edit&redlink=1" class="new" title="三叶形纽结折叠（页面不存在）">三叶形纽结折叠</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Trefoil_knot_fold" class="extiw" title="en:Trefoil knot fold"><span lang="en" dir="auto">Trefoil knot fold</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">α+β型折叠</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/DNA%E5%A4%BE" title="DNA夾">DNA钳</a></li> <li><span class="ilh-all" data-orig-title="铁氧化还原蛋白折叠" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ferredoxin fold"><span class="ilh-page"><a href="/w/index.php?title=%E9%93%81%E6%B0%A7%E5%8C%96%E8%BF%98%E5%8E%9F%E8%9B%8B%E7%99%BD%E6%8A%98%E5%8F%A0&action=edit&redlink=1" class="new" title="铁氧化还原蛋白折叠（页面不存在）">铁氧化还原蛋白折叠</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ferredoxin_fold" class="extiw" title="en:Ferredoxin fold"><span lang="en" dir="auto">Ferredoxin fold</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="胰核糖核酸酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Pancreatic ribonuclease"><span class="ilh-page"><a href="/w/index.php?title=%E8%83%B0%E6%A0%B8%E7%B3%96%E6%A0%B8%E9%85%B8%E9%85%B6&action=edit&redlink=1" class="new" title="胰核糖核酸酶（页面不存在）">胰核糖核酸酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Pancreatic_ribonuclease" class="extiw" title="en:Pancreatic ribonuclease"><span lang="en" dir="auto">Pancreatic ribonuclease</span></a></span>）</span></span></li> <li><a href="/wiki/SH2%E7%BB%93%E6%9E%84%E5%9F%9F" title="SH2结构域">类SH2折叠</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">非常態摺疊</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="芋螺毒素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Conotoxin"><span class="ilh-page"><a href="/w/index.php?title=%E8%8A%8B%E8%9E%BA%E6%AF%92%E7%B4%A0&action=edit&redlink=1" class="new" title="芋螺毒素（页面不存在）">芋螺毒素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Conotoxin" class="extiw" title="en:Conotoxin"><span lang="en" dir="auto">Conotoxin</span></a></span>）</span></span></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><div style="float:left;"><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E4%BA%8C%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质二级结构">←二級結構</a> </div><div style="float:right;"> <a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%9B%9B%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质四级结构">四級結構→</a></div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84261037"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"></div><div role="navigation" class="navbox" aria-labelledby="蛋白质" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="collapsible-title navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:蛋白质"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/w/index.php?title=Template_talk:%E8%9B%8B%E7%99%BD%E8%B4%A8&action=edit&redlink=1" class="new" title="Template talk:蛋白质（页面不存在）"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Special:编辑页面/Template:蛋白质"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="蛋白质" style="font-size:110%;margin:0 5em"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8" title="蛋白质">蛋白质</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">过程</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B3%AA%E7%94%9F%E7%89%A9%E5%90%88%E6%88%90" title="蛋白質生物合成">蛋白質生物合成</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E7%BF%BB%E8%AF%91%E5%90%8E%E4%BF%AE%E9%A5%B0" title="翻译后修饰">翻译后修饰</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a class="mw-selflink selflink">蛋白质折叠</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <span class="ilh-all" data-orig-title="蛋白质导向" data-lang-code="en" data-lang-name="英语" data-foreign-title="Protein targeting"><span class="ilh-page"><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%AF%BC%E5%90%91&action=edit&redlink=1" class="new" title="蛋白质导向（页面不存在）">蛋白质导向</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Protein_targeting" class="extiw" title="en:Protein targeting"><span lang="en" dir="auto">Protein targeting</span></a></span>）</span></span><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%84" title="蛋白质组">蛋白质组</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%96%B9%E6%B3%95" title="蛋白质方法">蛋白质方法</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">结构</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84" title="蛋白质结构">蛋白质结构</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84%E5%9F%9F" title="蛋白质结构域">蛋白质结构域</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E8%9B%8B%E7%99%BD%E9%85%B6%E4%BD%93" title="蛋白酶体">蛋白酶体</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">类型</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"><span class="ilh-all" data-orig-title="蛋白质类型列表" data-lang-code="en" data-lang-name="英语" data-foreign-title="List of types of proteins"><span class="ilh-page"><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%B1%BB%E5%9E%8B%E5%88%97%E8%A1%A8&action=edit&redlink=1" class="new" title="蛋白质类型列表（页面不存在）">蛋白质类型列表</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/List_of_types_of_proteins" class="extiw" title="en:List of types of proteins"><span lang="en" dir="auto">List of types of proteins</span></a></span>）</span></span><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%88%97%E8%A1%A8" title="蛋白质列表">蛋白质列表</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E8%86%9C%E8%9B%8B%E7%99%BD%E8%B4%A8" title="膜蛋白质">膜蛋白</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E7%90%83%E7%8A%B6%E8%9B%8B%E7%99%BD%E8%B4%A8" title="球状蛋白质">球状蛋白质</a>（<a href="/wiki/%E7%90%83%E8%9B%8B%E7%99%BD" title="球蛋白">球蛋白</a>、<a href="/wiki/%E7%99%BD%E8%9B%8B%E7%99%BD" title="白蛋白">白蛋白</a>）<span style="white-space:nowrap; font-weight:bold;"> ·</span> <a href="/wiki/%E7%A1%AC%E8%9B%8B%E7%99%BD" title="硬蛋白">纤维状蛋白</a><span style="white-space:nowrap; font-weight:bold;"> ·</span> <span class="ilh-all" data-orig-title="胆素蛋白质" data-lang-code="en" data-lang-name="英语" data-foreign-title="Biliprotein"><span class="ilh-page"><a href="/w/index.php?title=%E8%83%86%E7%B4%A0%E8%9B%8B%E7%99%BD%E8%B4%A8&action=edit&redlink=1" class="new" title="胆素蛋白质（页面不存在）">胆素蛋白质</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Biliprotein" class="extiw" title="en:Biliprotein"><span lang="en" dir="auto">Biliprotein</span></a></span>）</span></span>（<a href="/wiki/%E8%97%BB%E8%86%BD%E8%9B%8B%E7%99%BD" title="藻膽蛋白">藻膽蛋白</a>、<a href="/wiki/%E5%85%89%E6%95%8F%E7%B4%A0" title="光敏素">光敏素</a>）</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="collapsible-title navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E7%89%A9%E8%B4%A8%E7%A7%8D%E7%B1%BB" title="Template:生物化学物质种类"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E7%89%A9%E8%B4%A8%E7%A7%8D%E7%B1%BB" title="Template talk:生物化学物质种类"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E7%89%A9%E8%B4%A8%E7%A7%8D%E7%B1%BB" title="Special:编辑页面/Template:生物化学物质种类"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="生物化學物質種類索引" style="font-size:110%;margin:0 5em"><a href="/wiki/%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6" title="生物化学">生物化學物質</a><a href="/wiki/Template:%E4%BB%A3%E8%B0%A2" title="Template:代谢">種類</a>索引</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Template:%E7%B3%96%E7%B1%BB" title="Template:糖类">糖类</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E9%86%87" title="Template:醇">醇類</a></li> <li><a href="/wiki/Template:%E5%A4%9A%E5%85%83%E9%86%87" title="Template:多元醇">糖醇</a></li> <li><a href="/wiki/Template:%E7%B3%96%E8%9B%8B%E7%99%BD%E7%B1%BB" title="Template:糖蛋白类">醣蛋白</a></li> <li><a href="/wiki/Template:%E7%B3%96%E8%8B%B7" title="Template:糖苷">苷</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Template:%E8%84%82%E7%B1%BB" title="Template:脂类">酯質</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E7%B1%BB%E8%8A%B1%E7%94%9F%E9%85%B8%E7%B1%BB" title="Template:类花生酸类">类花生酸类</a></li> <li><a href="/wiki/Template:%E8%84%82%E8%82%AA%E9%85%B8" title="Template:脂肪酸">脂肪酸</a> <ul><li><a href="/wiki/Template:%E8%84%82%E8%82%AA%E9%85%B8%E4%BB%A3%E8%B0%A2%E4%B8%AD%E9%97%B4%E4%BA%A7%E7%89%A9" title="Template:脂肪酸代谢中间产物">中間物</a></li></ul></li> <li><a href="/wiki/Template:Glycerides" title="Template:Glycerides">甘油酯</a></li> <li><a href="/wiki/Template:%E7%A3%B7%E8%84%82" title="Template:磷脂">磷脂</a></li> <li><a href="/wiki/Template:%E9%9E%98%E8%84%82" title="Template:鞘脂">鞘脂類</a></li> <li><a href="/wiki/Template:%E8%83%86%E5%9B%BA%E9%86%87%E4%B8%8E%E7%94%BE%E4%BD%93%E4%B8%AD%E9%97%B4%E4%BA%A7%E7%89%A9" title="Template:胆固醇与甾体中间产物">胆固醇与甾体中间产物</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Template:%E6%A0%B8%E9%85%B8" title="Template:核酸">核酸</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E7%A2%B1%E5%9F%BA%E3%80%81%E6%A0%B8%E8%8B%B7%E5%92%8C%E6%A0%B8%E8%8B%B7%E9%85%B8" title="Template:碱基、核苷和核苷酸">成分</a> <ul><li><a href="/wiki/Template:%E6%A0%B8%E8%8B%B7%E9%85%B8%E4%BB%A3%E8%B0%A2%E4%B8%AD%E9%97%B4%E4%BA%A7%E7%89%A9" title="Template:核苷酸代谢中间产物">中間物</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:蛋白质">蛋白質</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E6%B0%A8%E5%9F%BA%E9%85%B8" title="Template:氨基酸">胺基酸</a> <ul><li><a href="/wiki/Template:%E6%B0%A8%E5%9F%BA%E9%85%B8%E4%BB%A3%E8%B0%A2%E4%B8%AD%E9%97%B4%E4%BA%A7%E7%89%A9" title="Template:氨基酸代谢中间产物">中間物</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">其他</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E5%9B%9B%E5%90%A1%E5%92%AF" title="Template:四吡咯">四吡咯</a> <ul><li><a href="/wiki/Template:%E8%A1%80%E7%BA%A2%E7%B4%A0%E4%BB%A3%E8%B0%A2%E4%B8%AD%E9%97%B4%E4%BA%A7%E7%89%A9" title="Template:血红素代谢中间产物">中間物</a></li></ul></li></ul> </div></td></tr></tbody></table><div><br /></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Protein_classification_navs" title="Template:Protein classification navs"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Protein_classification_navs" title="Template talk:Protein classification navs"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:Protein_classification_navs" title="Special:编辑页面/Template:Protein classification navs"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="蛋白质索引" style="font-size:110%;margin:0 5em"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8" title="蛋白质">蛋白质</a>索引</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">描述</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:蛋白质">蛋白质</a></li> <li><a href="/wiki/Template:%E5%85%B6%E5%AE%83%E7%BB%86%E8%83%9E%E8%86%9C%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:其它细胞膜蛋白质">膜蛋白</a></li> <li><a href="/wiki/Template:%E7%90%83%E7%8A%B6%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:球状蛋白质">球蛋白</a> <ul><li><a href="/wiki/Template:%E9%85%B6" title="Template:酶">酶</a></li> <li><a href="/wiki/Template:%E8%BD%BD%E4%BD%93%E8%9B%8B%E7%99%BD" title="Template:载体蛋白">载体</a></li></ul></li> <li><a href="/wiki/Template:%E6%8A%97%E4%BD%93" title="Template:抗体">抗生素</a></li> <li><a href="/wiki/Template:%E7%BA%A4%E7%BB%B4%E7%8A%B6%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:纤维状蛋白质">纖維狀</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84261037"></div><div role="navigation" class="navbox" aria-labelledby="生物分子结构（英语：-&#123;Biomolecular_structure&#125;-）" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="collapsible-title navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E7%94%9F%E7%89%A9%E5%88%86%E5%AD%90%E7%BB%93%E6%9E%84" title="Template:生物分子结构"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:%E7%94%9F%E7%89%A9%E5%88%86%E5%AD%90%E7%BB%93%E6%9E%84" title="Template talk:生物分子结构"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E7%94%9F%E7%89%A9%E5%88%86%E5%AD%90%E7%BB%93%E6%9E%84" title="Special:编辑页面/Template:生物分子结构"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="生物分子结构（英语：-&#123;Biomolecular_structure&#125;-）" style="font-size:110%;margin:0 5em"><span class="ilh-all" data-orig-title="生物分子结构" data-lang-code="en" data-lang-name="英语" data-foreign-title="Biomolecular structure"><span class="ilh-page"><a href="/w/index.php?title=%E7%94%9F%E7%89%A9%E5%88%86%E5%AD%90%E7%BB%93%E6%9E%84&action=edit&redlink=1" class="new" title="生物分子结构（页面不存在）">生物分子结构</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Biomolecular_structure" class="extiw" title="en:Biomolecular structure"><span lang="en" dir="auto">Biomolecular structure</span></a></span>）</span></span></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84" title="蛋白质结构">蛋白质结构</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B3%AA%E4%B8%80%E7%B4%9A%E7%B5%90%E6%A7%8B" title="蛋白質一級結構">一级</a></li> <li><a href="/wiki/%E4%BA%8C%E7%B4%9A%E7%B5%90%E6%A7%8B" title="二級結構">二级</a></li> <li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B3%AA%E4%B8%89%E7%B4%9A%E7%B5%90%E6%A7%8B" title="蛋白質三級結構">三级</a></li> <li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%9B%9B%E7%BA%A7%E7%BB%93%E6%9E%84" title="蛋白质四级结构">四级</a></li> <li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84#蛋白质结构测定" title="蛋白质结构">测定</a></li> <li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84%E9%A2%84%E6%B5%8B" title="蛋白质结构预测">预测</a></li> <li><span class="ilh-all" data-orig-title="蛋白质设计" data-lang-code="en" data-lang-name="英语" data-foreign-title="Protein design"><span class="ilh-page"><a href="/w/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E8%AE%BE%E8%AE%A1&action=edit&redlink=1" class="new" title="蛋白质设计（页面不存在）">设计</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Protein_design" class="extiw" title="en:Protein design"><span lang="en" dir="auto">Protein design</span></a></span>）</span></span></li> <li><a class="mw-selflink selflink">热力学</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%E6%A0%B8%E9%85%B8%E7%B5%90%E6%A7%8B" title="核酸結構">核酸结构</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E6%A0%B8%E9%85%B8%E5%BA%8F%E5%88%97" title="核酸序列">一级</a></li> <li><a href="/wiki/%E6%A0%B8%E9%85%B8%E4%BA%8C%E7%BA%A7%E7%BB%93%E6%9E%84" title="核酸二级结构">二级</a></li> <li><a href="/wiki/%E6%A0%B8%E9%85%B8%E4%B8%89%E7%BA%A7%E7%BB%93%E6%9E%84" title="核酸三级结构">三级</a></li> <li><span class="ilh-all" data-orig-title="核酸四级结构" data-lang-code="en" data-lang-name="英语" data-foreign-title="Nucleic acid quaternary structure"><span class="ilh-page"><a href="/w/index.php?title=%E6%A0%B8%E9%85%B8%E5%9B%9B%E7%BA%A7%E7%BB%93%E6%9E%84&action=edit&redlink=1" class="new" title="核酸四级结构（页面不存在）">四级</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Nucleic_acid_quaternary_structure" class="extiw" title="en:Nucleic acid quaternary structure"><span lang="en" dir="auto">Nucleic acid quaternary structure</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="核酸结构测定" data-lang-code="en" data-lang-name="英语" data-foreign-title="Nucleic acid structure determination"><span class="ilh-page"><a href="/w/index.php?title=%E6%A0%B8%E9%85%B8%E7%BB%93%E6%9E%84%E6%B5%8B%E5%AE%9A&action=edit&redlink=1" class="new" title="核酸结构测定（页面不存在）">测定</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Nucleic_acid_structure_determination" class="extiw" title="en:Nucleic acid structure determination"><span lang="en" dir="auto">Nucleic acid structure determination</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="核酸结构预测" data-lang-code="en" data-lang-name="英语" data-foreign-title="Nucleic acid structure prediction"><span class="ilh-page"><a href="/w/index.php?title=%E6%A0%B8%E9%85%B8%E7%BB%93%E6%9E%84%E9%A2%84%E6%B5%8B&action=edit&redlink=1" class="new" title="核酸结构预测（页面不存在）">预测</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Nucleic_acid_structure_prediction" class="extiw" title="en:Nucleic acid structure prediction"><span lang="en" dir="auto">Nucleic acid structure prediction</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="核酸设计" data-lang-code="en" data-lang-name="英语" data-foreign-title="Nucleic acid design"><span class="ilh-page"><a href="/w/index.php?title=%E6%A0%B8%E9%85%B8%E8%AE%BE%E8%AE%A1&action=edit&redlink=1" class="new" title="核酸设计（页面不存在）">设计</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Nucleic_acid_design" class="extiw" title="en:Nucleic acid design"><span lang="en" dir="auto">Nucleic acid design</span></a></span>）</span></span></li> <li><a href="/wiki/%E6%A0%B8%E9%85%B8%E7%83%AD%E5%8A%9B%E5%AD%A6" title="核酸热力学">热力学</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">参阅</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8" title="蛋白质">蛋白质</a></li> <li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%BB%93%E6%9E%84%E5%9F%9F" title="蛋白质结构域">蛋白质结构域</a></li> <li><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%B7%A5%E7%A8%8B" class="mw-redirect" title="蛋白质工程">蛋白质工程</a></li> <li><a href="/wiki/%E6%A0%B8%E9%85%B8" title="核酸">核酸</a></li> <li><a href="/wiki/%E8%84%B1%E6%B0%A7%E6%A0%B8%E7%B3%96%E6%A0%B8%E9%85%B8" title="脱氧核糖核酸">脱氧核糖核酸（DNA）</a></li> <li><a href="/wiki/%E6%A0%B8%E7%B3%96%E6%A0%B8%E9%85%B8" title="核糖核酸">核糖核酸（RNA）</a></li> <li><a href="/wiki/%E6%A0%B8%E9%85%B8%E5%8F%8C%E8%9E%BA%E6%97%8B" title="核酸双螺旋">核酸双螺旋</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84261037"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"></div><div role="navigation" class="navbox" aria-labelledby="翻译后修饰" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="collapsible-title navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E7%BF%BB%E8%AF%91%E5%90%8E%E4%BF%AE%E9%A5%B0" title="Template:翻译后修饰"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:%E7%BF%BB%E8%AF%91%E5%90%8E%E4%BF%AE%E9%A5%B0" title="Template talk:翻译后修饰"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E7%BF%BB%E8%AF%91%E5%90%8E%E4%BF%AE%E9%A5%B0" title="Special:编辑页面/Template:翻译后修饰"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="翻译后修饰" style="font-size:110%;margin:0 5em"><a href="/wiki/%E7%BF%BB%E8%AF%91%E5%90%8E%E4%BF%AE%E9%A5%B0" title="翻译后修饰">翻译后修饰</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/%E5%88%86%E5%AD%90%E4%BC%B4%E4%BE%A3" title="分子伴侣">分子伴侣</a>/<br /><a class="mw-selflink selflink">蛋白质折叠</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/%E7%83%AD%E4%BC%91%E5%85%8B%E8%9B%8B%E7%99%BD" title="热休克蛋白">热休克蛋白</a>/<br /><span class="ilh-all" data-orig-title="伴侣素" data-lang-code="en" data-lang-name="英语" data-foreign-title="Chaperonin"><span class="ilh-page"><a href="/w/index.php?title=%E4%BC%B4%E4%BE%A3%E7%B4%A0&action=edit&redlink=1" class="new" title="伴侣素（页面不存在）">伴侣素</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Chaperonin" class="extiw" title="en:Chaperonin"><span lang="en" dir="auto">Chaperonin</span></a></span>）</span></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/w/index.php?title=GroES&action=edit&redlink=1" class="new" title="GroES（页面不存在）">Hsp10/GroES</a> <ul><li><span class="ilh-all" data-orig-title="早孕因子" data-lang-code="en" data-lang-name="英语" data-foreign-title="Early pregnancy factor"><span class="ilh-page"><a href="/w/index.php?title=%E6%97%A9%E5%AD%95%E5%9B%A0%E5%AD%90&action=edit&redlink=1" class="new" title="早孕因子（页面不存在）">早孕因子</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Early_pregnancy_factor" class="extiw" title="en:Early pregnancy factor"><span lang="en" dir="auto">Early pregnancy factor</span></a></span>）</span></span></li></ul></li> <li><a href="/w/index.php?title=Hsp27&action=edit&redlink=1" class="new" title="Hsp27（页面不存在）">Hsp27</a></li> <li><a href="/w/index.php?title=Heat_shock_protein_47&action=edit&redlink=1" class="new" title="Heat shock protein 47（页面不存在）">Hsp47</a></li> <li><a href="/w/index.php?title=HSP60&action=edit&redlink=1" class="new" title="HSP60（页面不存在）">HSP60</a>/<a href="/w/index.php?title=GroEL&action=edit&redlink=1" class="new" title="GroEL（页面不存在）">GroEL</a></li></ul> <ul><li><a href="/w/index.php?title=Hsp40&action=edit&redlink=1" class="new" title="Hsp40（页面不存在）">Hsp40/DnaJ</a> <ul><li><a href="/w/index.php?title=DNAJA1&action=edit&redlink=1" class="new" title="DNAJA1（页面不存在）">A1</a></li> <li><a href="/w/index.php?title=DNAJA2&action=edit&redlink=1" class="new" title="DNAJA2（页面不存在）">A2</a></li> <li><a href="/w/index.php?title=DNAJA3&action=edit&redlink=1" class="new" title="DNAJA3（页面不存在）">A3</a></li> <li><a href="/w/index.php?title=DNAJB1&action=edit&redlink=1" class="new" title="DNAJB1（页面不存在）">B1</a></li> <li><a href="/w/index.php?title=DNAJB2&action=edit&redlink=1" class="new" title="DNAJB2（页面不存在）">B2</a></li> <li><a href="/w/index.php?title=DNAJB11&action=edit&redlink=1" class="new" title="DNAJB11（页面不存在）">B11</a></li> <li><a href="/w/index.php?title=DNAJB4&action=edit&redlink=1" class="new" title="DNAJB4（页面不存在）">B4</a></li> <li><a href="/w/index.php?title=DNAJB6&action=edit&redlink=1" class="new" title="DNAJB6（页面不存在）">B6</a></li> <li><a href="/w/index.php?title=DNAJB9&action=edit&redlink=1" class="new" title="DNAJB9（页面不存在）">B9</a></li> <li><a href="/w/index.php?title=DNAJC1&action=edit&redlink=1" class="new" title="DNAJC1（页面不存在）">C1</a></li> <li><a href="/w/index.php?title=DNAJC3&action=edit&redlink=1" class="new" title="DNAJC3（页面不存在）">C3</a></li> <li><a href="/w/index.php?title=DNAJC5&action=edit&redlink=1" class="new" title="DNAJC5（页面不存在）">C5</a></li> <li><a href="/w/index.php?title=DNAJC6&action=edit&redlink=1" class="new" title="DNAJC6（页面不存在）">C6</a></li> <li><a href="/w/index.php?title=DNAJC7&action=edit&redlink=1" class="new" title="DNAJC7（页面不存在）">C7</a></li> <li><a href="/w/index.php?title=DNAJC10&action=edit&redlink=1" class="new" title="DNAJC10（页面不存在）">C10</a></li> <li><a href="/w/index.php?title=DNAJC11&action=edit&redlink=1" class="new" title="DNAJC11（页面不存在）">C11</a></li> <li><a href="/w/index.php?title=DNAJC13&action=edit&redlink=1" class="new" title="DNAJC13（页面不存在）">C13</a></li> <li><a href="/w/index.php?title=DNAJC14&action=edit&redlink=1" class="new" title="DNAJC14（页面不存在）">C14</a></li> <li><a href="/w/index.php?title=DNAJC19&action=edit&redlink=1" class="new" title="DNAJC19（页面不存在）">C19</a></li></ul></li></ul> <ul><li><a href="/w/index.php?title=Hsp70&action=edit&redlink=1" class="new" title="Hsp70（页面不存在）">Hsp70</a> <ul><li><a href="/w/index.php?title=HSPA1A&action=edit&redlink=1" class="new" title="HSPA1A（页面不存在）">1A</a></li> <li><a href="/w/index.php?title=HSPA1B&action=edit&redlink=1" class="new" title="HSPA1B（页面不存在）">1B</a></li> <li><a href="/w/index.php?title=HSPA1L&action=edit&redlink=1" class="new" title="HSPA1L（页面不存在）">1L</a></li> <li><a href="/w/index.php?title=HSPA2&action=edit&redlink=1" class="new" title="HSPA2（页面不存在）">2</a></li> <li><a href="/w/index.php?title=HSPA4&action=edit&redlink=1" class="new" title="HSPA4（页面不存在）">4</a></li> <li><a href="/w/index.php?title=HSPA4L&action=edit&redlink=1" class="new" title="HSPA4L（页面不存在）">4L</a></li> <li><a href="/w/index.php?title=Binding_immunoglobulin_protein&action=edit&redlink=1" class="new" title="Binding immunoglobulin protein（页面不存在）">5</a></li> <li><a href="/w/index.php?title=HSPA6&action=edit&redlink=1" class="new" title="HSPA6（页面不存在）">6</a></li> <li><a href="/w/index.php?title=HSPA7&action=edit&redlink=1" class="new" title="HSPA7（页面不存在）">7</a></li> <li><a href="/w/index.php?title=HSPA8&action=edit&redlink=1" class="new" title="HSPA8（页面不存在）">8</a></li> <li><a href="/w/index.php?title=HSPA9&action=edit&redlink=1" class="new" title="HSPA9（页面不存在）">9</a></li> <li><a href="/w/index.php?title=HSPA12A&action=edit&redlink=1" class="new" title="HSPA12A（页面不存在）">12A</a></li> <li><a href="/w/index.php?title=HSPA14&action=edit&redlink=1" class="new" title="HSPA14（页面不存在）">14</a></li></ul></li></ul> <ul><li><a href="/w/index.php?title=Hsp90&action=edit&redlink=1" class="new" title="Hsp90（页面不存在）">Hsp90</a> <ul><li><a href="/w/index.php?title=Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1&action=edit&redlink=1" class="new" title="Heat shock protein 90kDa alpha (cytosolic), member A1（页面不存在）">α<sub>1</sub></a></li> <li><a href="/w/index.php?title=HSP90AA2&action=edit&redlink=1" class="new" title="HSP90AA2（页面不存在）">α<sub>2</sub></a></li> <li><a href="/w/index.php?title=HSP90AB1&action=edit&redlink=1" class="new" title="HSP90AB1（页面不存在）">β</a></li> <li><a href="/w/index.php?title=HSP90B1&action=edit&redlink=1" class="new" title="HSP90B1（页面不存在）">ER</a></li> <li><a href="/w/index.php?title=TRAP1&action=edit&redlink=1" class="new" title="TRAP1（页面不存在）">TRAP1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">其它</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/w/index.php?title=Alpha_crystallin&action=edit&redlink=1" class="new" title="Alpha crystallin（页面不存在）">Alpha crystallin</a></li> <li><a href="/w/index.php?title=Clusterin&action=edit&redlink=1" class="new" title="Clusterin（页面不存在）">Clusterin</a></li> <li><a href="/w/index.php?title=Survival_of_motor_neuron&action=edit&redlink=1" class="new" title="Survival of motor neuron（页面不存在）">Survival of motor neuron</a> <ul><li><a href="/w/index.php?title=SMN1&action=edit&redlink=1" class="new" title="SMN1（页面不存在）">SMN1</a></li> <li><a href="/w/index.php?title=SMN2&action=edit&redlink=1" class="new" title="SMN2（页面不存在）">SMN2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%AF%BB%E9%9D%B6" title="蛋白质寻靶">靶向运输</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E4%BF%A1%E5%8F%B7%E8%82%BD" title="信号肽">信号肽</a> <ul><li><span class="ilh-all" data-orig-title="导肽" data-lang-code="en" data-lang-name="英语" data-foreign-title="Target peptide"><span class="ilh-page"><a href="/w/index.php?title=%E5%AF%BC%E8%82%BD&action=edit&redlink=1" class="new" title="导肽（页面不存在）">线粒体导肽</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Target_peptide" class="extiw" title="en:Target peptide"><span lang="en" dir="auto">Target peptide</span></a></span>）</span></span></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/%E6%B3%9B%E7%B4%A0" title="泛素">泛素</a>化</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><b>E1</b> <span class="ilh-all" data-orig-title="泛素活化酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ubiquitin-activating enzyme"><span class="ilh-page"><a href="/w/index.php?title=%E6%B3%9B%E7%B4%A0%E6%B4%BB%E5%8C%96%E9%85%B6&action=edit&redlink=1" class="new" title="泛素活化酶（页面不存在）">泛素活化酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ubiquitin-activating_enzyme" class="extiw" title="en:Ubiquitin-activating enzyme"><span lang="en" dir="auto">Ubiquitin-activating enzyme</span></a></span>）</span></span> <ul><li><a href="/w/index.php?title=UBE1&action=edit&redlink=1" class="new" title="UBE1（页面不存在）">UBA1</a></li> <li><a href="/w/index.php?title=SAE2&action=edit&redlink=1" class="new" title="SAE2（页面不存在）">UBA2</a></li> <li><a href="/w/index.php?title=UBE1C&action=edit&redlink=1" class="new" title="UBE1C（页面不存在）">UBA3</a></li> <li><a href="/w/index.php?title=UBE1DC1&action=edit&redlink=1" class="new" title="UBE1DC1（页面不存在）">UBA5</a></li> <li><a href="/w/index.php?title=UBE1L2&action=edit&redlink=1" class="new" title="UBE1L2（页面不存在）">UBA6</a></li> <li><a href="/w/index.php?title=UBE1L&action=edit&redlink=1" class="new" title="UBE1L（页面不存在）">UBA7</a></li> <li><a href="/w/index.php?title=ATG7&action=edit&redlink=1" class="new" title="ATG7（页面不存在）">ATG7</a></li> <li><a href="/w/index.php?title=APPBP1&action=edit&redlink=1" class="new" title="APPBP1（页面不存在）">NAE1</a></li> <li><a href="/w/index.php?title=SAE1&action=edit&redlink=1" class="new" title="SAE1（页面不存在）">SAE1</a></li></ul></li></ul> <ul><li><b>E2</b> <span class="ilh-all" data-orig-title="泛素缀合酶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ubiquitin-conjugating enzyme"><span class="ilh-page"><a href="/w/index.php?title=%E6%B3%9B%E7%B4%A0%E7%BC%80%E5%90%88%E9%85%B6&action=edit&redlink=1" class="new" title="泛素缀合酶（页面不存在）">泛素缀合酶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ubiquitin-conjugating_enzyme" class="extiw" title="en:Ubiquitin-conjugating enzyme"><span lang="en" dir="auto">Ubiquitin-conjugating enzyme</span></a></span>）</span></span> <ul><li><a href="/w/index.php?title=UBE2A&action=edit&redlink=1" class="new" title="UBE2A（页面不存在）">A</a></li> <li><a href="/w/index.php?title=UBE2B&action=edit&redlink=1" class="new" title="UBE2B（页面不存在）">B</a></li> <li><a href="/w/index.php?title=UBE2C&action=edit&redlink=1" class="new" title="UBE2C（页面不存在）">C</a></li> <li><a href="/w/index.php?title=UBE2D1&action=edit&redlink=1" class="new" title="UBE2D1（页面不存在）">D1</a></li> <li><a href="/w/index.php?title=UBE2D2&action=edit&redlink=1" class="new" title="UBE2D2（页面不存在）">D2</a></li> <li><a href="/w/index.php?title=UBE2D3&action=edit&redlink=1" class="new" title="UBE2D3（页面不存在）">D3</a></li> <li><a href="/w/index.php?title=UBE2E1&action=edit&redlink=1" class="new" title="UBE2E1（页面不存在）">E1</a></li> <li><a href="/w/index.php?title=UBE2E2&action=edit&redlink=1" class="new" title="UBE2E2（页面不存在）">E2</a></li> <li><a href="/w/index.php?title=UBE2E3&action=edit&redlink=1" class="new" title="UBE2E3（页面不存在）">E3</a></li> <li><a href="/w/index.php?title=UBE2G1&action=edit&redlink=1" class="new" title="UBE2G1（页面不存在）">G1</a></li> <li><a href="/w/index.php?title=UBE2G2&action=edit&redlink=1" class="new" title="UBE2G2（页面不存在）">G2</a></li> <li><a href="/w/index.php?title=UBE2H&action=edit&redlink=1" class="new" title="UBE2H（页面不存在）">H</a></li> <li><a href="/w/index.php?title=UBE2I&action=edit&redlink=1" class="new" title="UBE2I（页面不存在）">I</a></li> <li><a href="/w/index.php?title=UBE2J1&action=edit&redlink=1" class="new" title="UBE2J1（页面不存在）">J1</a></li> <li><a href="/w/index.php?title=UBE2J2&action=edit&redlink=1" class="new" title="UBE2J2（页面不存在）">J2</a></li> <li><a href="/w/index.php?title=UBE2K&action=edit&redlink=1" class="new" title="UBE2K（页面不存在）">K</a></li> <li><a href="/w/index.php?title=UBE2L1&action=edit&redlink=1" class="new" title="UBE2L1（页面不存在）">L1</a></li> <li><a href="/w/index.php?title=UBE2L2&action=edit&redlink=1" class="new" title="UBE2L2（页面不存在）">L2</a></li> <li><a href="/w/index.php?title=UBE2L3&action=edit&redlink=1" class="new" title="UBE2L3（页面不存在）">L3</a></li> <li><a href="/w/index.php?title=UBE2L4&action=edit&redlink=1" class="new" title="UBE2L4（页面不存在）">L4</a></li> <li><a href="/w/index.php?title=UBE2L6&action=edit&redlink=1" class="new" title="UBE2L6（页面不存在）">L6</a></li> <li><a href="/w/index.php?title=UBE2M&action=edit&redlink=1" class="new" title="UBE2M（页面不存在）">M</a></li> <li><a href="/w/index.php?title=UBE2N&action=edit&redlink=1" class="new" title="UBE2N（页面不存在）">N</a></li> <li><a href="/w/index.php?title=UBE2O&action=edit&redlink=1" class="new" title="UBE2O（页面不存在）">O</a></li> <li><a href="/w/index.php?title=UBE2Q1&action=edit&redlink=1" class="new" title="UBE2Q1（页面不存在）">Q1</a></li> <li><a href="/w/index.php?title=UBE2Q2&action=edit&redlink=1" class="new" title="UBE2Q2（页面不存在）">Q2</a></li> <li><a href="/w/index.php?title=CDC34&action=edit&redlink=1" class="new" title="CDC34（页面不存在）">R1</a> (CDC34)</li> <li><a href="/w/index.php?title=UBE2R2&action=edit&redlink=1" class="new" title="UBE2R2（页面不存在）">R2</a></li> <li><a href="/w/index.php?title=UBE2S&action=edit&redlink=1" class="new" title="UBE2S（页面不存在）">S</a></li> <li><a href="/w/index.php?title=UBE2V1&action=edit&redlink=1" class="new" title="UBE2V1（页面不存在）">V1</a></li> <li><a href="/w/index.php?title=UBE2V2&action=edit&redlink=1" class="new" title="UBE2V2（页面不存在）">V2</a></li> <li><a href="/w/index.php?title=UBE2Z&action=edit&redlink=1" class="new" title="UBE2Z（页面不存在）">Z</a></li></ul></li></ul> <ul><li><b>E3</b> <a href="/wiki/%E6%B3%9B%E7%B4%A0%E8%BF%9E%E6%8E%A5%E9%85%B6" title="泛素连接酶">泛素连接酶</a> <ul><li><a href="/w/index.php?title=Von_Hippel%E2%80%93Lindau_tumor_suppressor&action=edit&redlink=1" class="new" title="Von Hippel–Lindau tumor suppressor（页面不存在）">VHL</a></li> <li><a href="/w/index.php?title=Cullin&action=edit&redlink=1" class="new" title="Cullin（页面不存在）">Cullin</a></li> <li><a href="/w/index.php?title=CBL_(gene)&action=edit&redlink=1" class="new" title="CBL (gene)（页面不存在）">CBL</a></li> <li><a href="/w/index.php?title=Mdm2&action=edit&redlink=1" class="new" title="Mdm2（页面不存在）">MDM2</a></li> <li><a href="/wiki/FANCL" title="FANCL">FANCL</a></li> <li><a href="/w/index.php?title=UBR1&action=edit&redlink=1" class="new" title="UBR1（页面不存在）">UBR1</a></li></ul></li></ul> <ul><li><a href="/w/index.php?title=Deubiquitinating_enzyme&action=edit&redlink=1" class="new" title="Deubiquitinating enzyme（页面不存在）">Deubiquitinating enzyme</a>: <a href="/w/index.php?title=Ataxin_3&action=edit&redlink=1" class="new" title="Ataxin 3（页面不存在）">Ataxin 3</a></li> <li><a href="/w/index.php?title=USP6&action=edit&redlink=1" class="new" title="USP6（页面不存在）">USP6</a></li> <li><a href="/w/index.php?title=CYLD_(gene)&action=edit&redlink=1" class="new" title="CYLD (gene)（页面不存在）">CYLD</a></li></ul> <ul><li><a href="/w/index.php?title=ATG3&action=edit&redlink=1" class="new" title="ATG3（页面不存在）">ATG3</a></li> <li><a href="/w/index.php?title=BIRC6&action=edit&redlink=1" class="new" title="BIRC6（页面不存在）">BIRC6</a></li> <li><a href="/w/index.php?title=UFC1_(gene)&action=edit&redlink=1" class="new" title="UFC1 (gene)（页面不存在）">UFC1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">其它</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li>泛素样修饰蛋白 <ul><li><span class="ilh-all" data-orig-title="SUMO蛋白质" data-lang-code="en" data-lang-name="英语" data-foreign-title="SUMO protein"><span class="ilh-page"><a href="/w/index.php?title=SUMO%E8%9B%8B%E7%99%BD%E8%B4%A8&action=edit&redlink=1" class="new" title="SUMO蛋白质（页面不存在）">SUMO 蛋白</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/SUMO_protein" class="extiw" title="en:SUMO protein"><span lang="en" dir="auto">SUMO protein</span></a></span>）</span></span></li> <li><a href="/w/index.php?title=ISG15&action=edit&redlink=1" class="new" title="ISG15（页面不存在）">ISG15</a></li> <li><a href="/w/index.php?title=URM1&action=edit&redlink=1" class="new" title="URM1（页面不存在）">URM1</a></li> <li><a href="/w/index.php?title=NEDD8&action=edit&redlink=1" class="new" title="NEDD8（页面不存在）">NEDD8</a></li> <li><a href="/w/index.php?title=FAT10&action=edit&redlink=1" class="new" title="FAT10（页面不存在）">FAT10</a></li> <li><a href="/w/index.php?title=ATG8&action=edit&redlink=1" class="new" title="ATG8（页面不存在）">ATG8</a></li> <li><a href="/w/index.php?title=ATG12&action=edit&redlink=1" class="new" title="ATG12（页面不存在）">ATG12</a></li> <li><a href="/w/index.php?title=FUB1&action=edit&redlink=1" class="new" title="FUB1（页面不存在）">FUB1</a></li> <li><a href="/w/index.php?title=Membrane-anchored_UBL&action=edit&redlink=1" class="new" title="Membrane-anchored UBL（页面不存在）">MUB</a></li> <li><a href="/w/index.php?title=UFM1&action=edit&redlink=1" class="new" title="UFM1（页面不存在）">UFM1</a></li> <li><a href="/w/index.php?title=UBL5&action=edit&redlink=1" class="new" title="UBL5（页面不存在）">UBL5</a></li></ul></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>See also: <a href="/w/index.php?title=Template:Posttranslational_modification_disorders&action=edit&redlink=1" class="new" title="Template:Posttranslational modification disorders（页面不存在）">posttranslational modification disorders</a></i><br /></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%94%9F%E7%89%A9%E5%90%88%E6%88%90%E5%AF%BC%E8%88%AA" title="Template:蛋白质生物合成导航"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%94%9F%E7%89%A9%E5%90%88%E6%88%90%E5%AF%BC%E8%88%AA" title="Template talk:蛋白质生物合成导航"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E7%94%9F%E7%89%A9%E5%90%88%E6%88%90%E5%AF%BC%E8%88%AA" title="Special:编辑页面/Template:蛋白质生物合成导航"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="遗传学索引" style="font-size:110%;margin:0 5em">遗传学索引</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">描述</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/Template:%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E6%A8%A1%E6%9D%BF%E6%80%BB%E8%A7%88" title="Template:生物化学模板总览">生化</a></li> <li><a href="/wiki/Template:%E5%9F%BA%E5%9B%A0%E8%A1%A8%E8%BE%BE" title="Template:基因表达">基因表达</a></li> <li>DNA <ul><li><a href="/wiki/Template:DNA%E5%A4%8D%E5%88%B6" title="Template:DNA复制">复制</a></li> <li><a href="/wiki/Template:%E7%BB%86%E8%83%9E%E5%91%A8%E6%9C%9F%E8%9B%8B%E7%99%BD%E8%B4%A8" title="Template:细胞周期蛋白质">周期蛋白</a></li> <li><a href="/wiki/Template:%E5%9F%BA%E5%9B%A0%E9%87%8D%E7%BB%84" title="Template:基因重组">基因重组</a></li> <li><a href="/wiki/Template:DNA%E4%BF%AE%E5%A4%8D" title="Template:DNA修复">修复</a></li></ul></li> <li><a href="/wiki/Template:%E8%BD%AC%E5%BD%95" title="Template:转录">转录</a> <ul><li><a href="/wiki/Template:%E8%BD%AC%E5%BD%95%E5%9B%A0%E5%AD%90%E4%B8%8E%E7%BB%86%E8%83%9E%E5%86%85%E5%8F%97%E4%BD%93" title="Template:转录因子与细胞内受体">转录因子与细胞内受体</a></li> <li><a href="/wiki/Template:Transcription_coregulators" title="Template:Transcription coregulators">辅调节因子</a></li> <li><a href="/wiki/Template:RNA%E7%B1%BB%E5%9E%8B" title="Template:RNA类型">RNA</a></li> <li><a href="/wiki/Template:%E9%87%8D%E5%A4%8D%E5%BA%8F%E5%88%97" title="Template:重复序列">重复序列</a></li> <li><a href="/wiki/Template:%E8%BD%AC%E5%BD%95%E5%90%8E%E4%BF%AE%E9%A5%B0" title="Template:转录后修饰">转录后修饰</a></li></ul></li> <li><a href="/wiki/Template:%E9%81%97%E4%BC%A0%E5%AD%A6/%E7%BF%BB%E8%AF%91" title="Template:遗传学/翻译">翻译</a> <ul><li><a href="/wiki/Template:%E6%A0%B8%E7%B3%96%E4%BD%93%E4%BA%9A%E5%9F%BA" title="Template:核糖体亚基">核糖体亚基</a></li> <li><a href="/wiki/Template:%E7%BF%BB%E8%AF%91%E5%90%8E%E4%BF%AE%E9%A5%B0" title="Template:翻译后修饰">翻译后修饰</a></li> <li><span class="ilh-all" data-orig-title="Template:Sorting nexin" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Sorting nexin"><span class="ilh-page"><a href="/w/index.php?title=Template:Sorting_nexin&action=edit&redlink=1" class="new" title="Template:Sorting nexin（页面不存在）">分拣蛋白</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Sorting_nexin" class="extiw" title="en:Template:Sorting nexin"><span lang="en" dir="auto">Template:Sorting nexin</span></a></span>）</span></span></li></ul></li> <li><span class="ilh-all" data-orig-title="Template:DNA-binding proteins" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:DNA-binding proteins"><span class="ilh-page"><a href="/w/index.php?title=Template:DNA-binding_proteins&action=edit&redlink=1" class="new" title="Template:DNA-binding proteins（页面不存在）">DNA结合蛋白</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:DNA-binding_proteins" class="extiw" title="en:Template:DNA-binding proteins"><span lang="en" dir="auto">Template:DNA-binding proteins</span></a></span>）</span></span>/<span class="ilh-all" data-orig-title="Template:RNA-binding proteins" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:RNA-binding proteins"><span class="ilh-page"><a href="/w/index.php?title=Template:RNA-binding_proteins&action=edit&redlink=1" class="new" title="Template:RNA-binding proteins（页面不存在）">RNA结合蛋白</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:RNA-binding_proteins" class="extiw" title="en:Template:RNA-binding proteins"><span lang="en" dir="auto">Template:RNA-binding proteins</span></a></span>）</span></span> <ul><li><a href="/wiki/Template:%E6%A0%B8%E7%B3%96%E6%A0%B8%E8%9B%8B%E7%99%BD" title="Template:核糖核蛋白">核糖核蛋白</a>)</li></ul></li> <li>蛋白质 <ul><li><a href="/wiki/Template:Protein_domains" title="Template:Protein domains">结构域</a></li> <li>结构 <ul><li><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E4%B8%80%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质一级结构">1°</a></li> <li><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E4%BA%8C%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质二级结构">2°</a></li> <li><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E8%B6%85%E4%BA%8C%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质超二级结构">2<sup>+</sup>°</a></li> <li><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E4%B8%89%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质三级结构">3°</a></li> <li><a href="/wiki/Template:%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%9B%9B%E7%BA%A7%E7%BB%93%E6%9E%84" title="Template:蛋白质四级结构">4°</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">疾病</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="Template:DNA replication and repair-deficiency disorder" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:DNA replication and repair-deficiency disorder"><span class="ilh-page"><a href="/w/index.php?title=Template:DNA_replication_and_repair-deficiency_disorder&action=edit&redlink=1" class="new" title="Template:DNA replication and repair-deficiency disorder（页面不存在）">Replication and repair</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:DNA_replication_and_repair-deficiency_disorder" class="extiw" title="en:Template:DNA replication and repair-deficiency disorder"><span lang="en" dir="auto">Template:DNA replication and repair-deficiency disorder</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="Template:Transcription factor and coregulator deficiencies" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Transcription factor and coregulator deficiencies"><span class="ilh-page"><a href="/w/index.php?title=Template:Transcription_factor_and_coregulator_deficiencies&action=edit&redlink=1" class="new" title="Template:Transcription factor and coregulator deficiencies（页面不存在）">Transcription factor</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Transcription_factor_and_coregulator_deficiencies" class="extiw" title="en:Template:Transcription factor and coregulator deficiencies"><span lang="en" dir="auto">Template:Transcription factor and coregulator deficiencies</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="Template:Disorders of transcription and post transcriptional modification" data-lang-code="en" data-lang-name="英语" data-foreign-title="Template:Disorders of transcription and post transcriptional modification"><span class="ilh-page"><a href="/w/index.php?title=Template:Disorders_of_transcription_and_post_transcriptional_modification&action=edit&redlink=1" class="new" title="Template:Disorders of transcription and post transcriptional modification（页面不存在）">转录相关疾病</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Template:Disorders_of_transcription_and_post_transcriptional_modification" class="extiw" title="en:Template:Disorders of transcription and post transcriptional modification"><span lang="en" dir="auto">Template:Disorders of transcription and post transcriptional modification</span></a></span>）</span></span></li> <li><a href="/wiki/Template:Disorders_of_translation_and_posttranslational_modification" title="Template:Disorders of translation and posttranslational modification">轉譯相關疾病</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div 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