Proteome Profiler Human Phospho-Kinase Array Kit ARY003C: R&D Systems

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class="ds_title_table"> <h1 class="ds_title">Proteome Profiler Human Phospho-Kinase Array Kit </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: ARY003C</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 389 Citations </a> </span> <span class="reviews review_stars_5"> <a href="#product-reviews" id="product_reviews" class="jump_to" data-tab="6" data-tabname="product-reviews"> 10 Reviews </a> </span> <a href="/reviews/ARY003C" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div> <div class="product_info">Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins</div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/proteome-profiler-human-phospho-kinase-array-kit_ary003c" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="ARY003C"> <td class="dat_catalog_column">ARY003C</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-ary003c form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-ary003c" 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<input type="hidden" name="form_build_id" value="form-WZ_yC7LwkESkGPoUPt-ofm-QnxVVr1cWUIoveExScKQ" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> </div> <div class="product_image_wrapper col-xs-12 col-md-4 col-md-pull-8"> <div class="bestseller_product"><span>Best Seller</span></div> <div class="product_image"> <span class="product_image_label"> </span> <a class="ds-image overview-images" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Detection of human protein kinase phosphorylation in A549 Cell Line." data-footer="Detection of Human Protein Kinase Phosphorylation in A549 Cell Line." title="Cat. No. ARY003C - Proteome Profiler Human Phospho-Kinase Array Kit" href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141555.png"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141555.png" class="img-fluid" alt="Detection of human protein kinase phosphorylation in A549 Cell Line." title="Detection of human protein kinase phosphorylation in A549 Cell Line."> </a> <div class="search_image_other_count"> <span class="search_more_images">4 Images</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." data-title="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." title="Cat. No. ARY003C - Proteome Profiler Human Phospho-Kinase Array Kit" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141653.png"> <img src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141653.png" class="img-fluid" loading="lazy" alt="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." title="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line."> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." data-title="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." title="Cat. No. ARY003C - Proteome Profiler Human Phospho-Kinase Array Kit" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141746.png"> <img src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141746.png" class="img-fluid" loading="lazy" alt="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." title="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line."> </a> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." data-title="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." title="Cat. No. ARY003C - Proteome Profiler Human Phospho-Kinase Array Kit" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141850.png"> <img src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141850.png" class="img-fluid" loading="lazy" alt="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." title="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line."> </a> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> View <a href="/target/kinase-assay-kits">All Products for Kinase Assay Kits</a> </div> </div>  <div class="tabbed_content" id="rnd_atlantabio">  <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (389)</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews (10) </span> </div> </div>  <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Images</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> </div> <div id="ds_summary" class="datasheet_section"> <h2>Proteome Profiler Human Phospho-Kinase Array Kit Summary</h2> <div id="ds_product_details" class="datasheet_section"> <div class="ds_lightBlueBar">Kit Summary</div> <h2>A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.</h2> <p><a href="/resources/technical/troubleshooting-guide-human-proteome-profiler-array-kits"><strong>Troubleshooting Guide</strong></a></p> <div class="grid_6"> <h3>Key Benefits</h3> <ul> <li>Detects phosphorylation of 37 human kinases and total amounts of 2 related proteins simultaneously</li> <li>Requires no specialized equipment</li> </ul> </div> <p> </p> <h3>Principle of the Assay</h3> <p>The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample <strong>(Step 1)</strong>. <span style="font-family: arial, sans-serif; font-size: 14px;">Captured proteins are detected with biotinylated detection antibodies</span> <strong>(Step 2)</strong> and then visualized using chemiluminescent detection reagents <strong>(Step 3)</strong>. The signal produced is proportional to the amount phosphorylation in the bound analyte.</p> <h3>Why Use an Antibody Array to Detect Receptor Phosphorylation?</h3> <p>Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.</p> <div class="clear"> </div> <p> </p> <div class="ds_lightBlueBar">Kit Contents</div> <p>Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.</p> <ul> <li>8 Array Membranes (4 of membrane A and 4 of membrane B)</li> <li>8-Well Multi-dish</li> <li>Lysis Buffer</li> <li>Array Buffers</li> <li>Wash Buffer</li> <li>Detection Antibody Cocktail A</li> <li>Detection Antibody Cocktail B</li> <li>Streptavidin-HRP</li> <li>Chemiluminescent Detection Reagents</li> <li>Transparency Overlay Template</li> <li>Detailed product datasheet with protocol</li> </ul> <p>For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the <a href="//resources.rndsystems.com/pdfs/datasheets/ary003c.pdf" target="_blank">product datasheet</a>.</p> <h3>Stability and Storage</h3> <p>Store the unopened kit at 2<sup>°</sup>C to 8<sup>°</sup>C. Do not use past kit expiration date.</p> <div class="clear"> </div> <table cellpadding="3" cellspacing="0" class="border" width="100%"> <tbody> <tr> <td class="blue_high" colspan="3">Simultaneously detect the relative phosphorylation of these proteins in a single sample.</td> </tr> <tr> <td width="33%">Akt 1/2/3 (S473)</td> <td width="33%">HSP60</td> <td width="33%">PRAS40 (T246)</td> </tr> <tr> <td>Akt 1/2/3 (T308)</td> <td>JNK 1/2/3 (T183/Y185, T221/Y223)</td> <td>Pyk2 (Y402)</td> </tr> <tr> <td>beta-Catenin</td> <td>Lck (Y394)</td> <td>RSK1/2 (S221/S227)</td> </tr> <tr> <td>Chk-2 (T68)</td> <td>Lyn (Y397)</td> <td>RSK1/2/3 (S380/S386/S377)</td> </tr> <tr> <td>c-Jun (S63)</td> <td>MSK1/2 (S376/S360)</td> <td>Src (Y419)</td> </tr> <tr> <td>CREB (S133)</td> <td>p38 alpha (T180/Y182)</td> <td>STAT1 (Y701)</td> </tr> <tr> <td>EGF R (Y1086)</td> <td>p53 (S15)</td> <td>STAT2 (Y690)</td> </tr> <tr> <td>eNOS (S1177)</td> <td>p53 (S392)</td> <td>STAT3 (S727)</td> </tr> <tr> <td>ERK1/2 (T202/Y204, T185/Y187)</td> <td>p53 (S46)</td> <td>STAT3 (Y705)</td> </tr> <tr> <td>Fgr (Y412)</td> <td>P70 S6 Kinase (T389)</td> <td>STAT5a/b (Y699)</td> </tr> <tr> <td>GSK-3 alpha/beta (S21/S9)</td> <td>p70 S6 Kinase (T421/S424)</td> <td>STAT6 (Y641)</td> </tr> <tr> <td>GSK-3 beta (S9)</td> <td>PDGF R beta (Y751)</td> <td>WNK-1 (T60)</td> </tr> <tr> <td>HSP27 (S78/S82)</td> <td>PLC gamma-1 (Y783)</td> <td>Yes (Y426)</td> </tr> </tbody> </table> <p> </p> <h3>Assays for analytes represented in the Human Phospho-Kinase Array Kit</h3> <p> </p> <table cellpadding="3" cellspacing="0" class="border" width="100%"> <tbody> <tr> <td class="blue_high">Analyte</td> <td class="blue_high">DuoSet<sup>®</sup> IC ELISA Development Systems (Total)</td> <td class="blue_high">DuoSet<sup>®</sup> IC ELISA<br /> Development Systems (Phospho)</td> <td class="blue_high">Quantikine<sup>®</sup><br /> ELISA Kits</td> </tr> <tr> <td width="33%">Akt (S473)</td> <td width="33%"> </td> <td width="33%"><a href="/products/phospho-akt-s473-pan-specific-duoset-ic-elisa_dyc887b-2">DYC887B</a></td> <td width="33%"> </td> </tr> <tr> <td>Akt (T308)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>beta-Catenin</td> <td><a href="/products/human-total-beta-catenin-duoset-ic-elisa_dyc1329-2">DYC1329</a></td> <td> </td> <td><u> </u></td> </tr> <tr> <td>Chk2 (T68)</td> <td> </td> <td><a href="/products/human-phospho-chk2-t68-duoset-ic-elisa_dyc1626-2">DYC1626</a></td> <td> </td> </tr> <tr> <td>c-Jun (S63)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>CREB (S133)</td> <td> </td> <td><a href="/products/human-mouse-rat-phospho-creb-s133-duoset-ic-elisa_dyc2510-2">DYC2510</a></td> <td> </td> </tr> <tr> <td>EGF R (Y1086)</td> <td><a href="/products/human-total-egf-r-erbb1-duoset-ic-elisa_dyc1854-2">DYC1854</a></td> <td> </td> <td><a href="/products/human-egf-r-erbb1-quantikine-elisa-kit_degfr0">DEGFR0</a></td> </tr> <tr> <td>eNOS (S1177)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>ERK1/2 (T202/Y204, T185/Y187)</td> <td> </td> <td><a href="/products/phospho-erk1-t202-y204-erk2-t185-y187-duoset-ic-elisa_dyc1018b-2">DYC1018B</a></td> <td> </td> </tr> <tr> <td>Fgr (Y412)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>GSK-3 beta (S9)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>GSK-3 alpha/beta (S21/S9)</td> <td><a href="/products/total-gsk-3-alpha-beta-duoset-ic-elisa_dyc2157-2">DYC2157</a></td> <td><a href="/products/phospho-gsk-3-alpha-beta-s21-s9-duoset-ic-elisa_dyc2630-2">DYC2630</a></td> <td> </td> </tr> <tr> <td>HSP27 (S78/S82)</td> <td><a href="/products/human-total-hsp27-duoset-ic-elisa_dyc1580-2">DYC1580</a></td> <td><a href="/products/phospho-hsp27-s78-s82-duoset-ic-elisa_dyc2314-2">DYC2314</a></td> <td> </td> </tr> <tr> <td>HSP60</td> <td><a href="/products/human-total-hsp60-duoset-ic-elisa_dyc1800-2">DYC1800</a></td> <td> </td> <td> </td> </tr> <tr> <td>JNK pan (T183/Y185, T221/Y223)</td> <td><a href="/products/human-mouse-rat-total-jnk-duoset-ic-elisa_dyc1205-2">DYC1205</a></td> <td><a href="/products/human-mouse-rat-phospho-jnk-pan-specific-duoset-ic-elisa_dyc1387b-22">DYC1387</a></td> <td> </td> </tr> <tr> <td>Lck (Y394)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>Lyn (Y397)</td> <td> </td> <td><a href="/products/human-phospho-lyn-y397-duoset-ic-elisa_dyc3936-2">DYC3936</a></td> <td> </td> </tr> <tr> <td>MSK1/2 (S376/S360)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>p38 alpha (T180/Y182)</td> <td><a href="/products/total-p38-alpha-duoset-ic-elisa_dyc8691b-2">DYC8691B</a></td> <td><a href="/products/phospho-p38-alpha-t180-y182-duoset-ic-elisa_dyc869b-2">DYC869B</a></td> <td> </td> </tr> <tr> <td>p53 (S15)</td> <td><a href="/products/human-total-p53-duoset-ic-elisa_dyc1043-2">DYC1043</a></td> <td><a href="/products/human-phospho-p53-s15-duoset-ic-elisa_dyc1839-2">DYC1839</a></td> <td> </td> </tr> <tr> <td>p53 (S46)</td> <td><a href="/products/human-total-p53-duoset-ic-elisa_dyc1043-2">DYC1043</a></td> <td><a href="/products/human-phospho-p53-s46-duoset-ic-elisa_dyc1489-2">DYC1489</a></td> <td> </td> </tr> <tr> <td>p53 (S392)</td> <td><a href="/products/human-total-p53-duoset-ic-elisa_dyc1043-2">DYC1043</a></td> <td><a href="/products/human-phospho-p53-s392-duoset-ic-elisa_dyc2996-2">DYC2996</a></td> <td> </td> </tr> <tr> <td>p70 S6 Kinase (T389)</td> <td> </td> <td><a href="/products/phospho-p70-s6-kinase-t389-duoset-ic-elisa_dyc896-2">DYC896</a></td> <td> </td> </tr> <tr> <td>p70 S6 Kinase (T421/S424)</td> <td><a href="/products/human-mouse-rat-total-p70-s6-kinase-duoset-ic-elisa_dyc8962-2">DYC8962</a></td> <td><a href="/products/phospho-p70-s6-kinase-t421-s424-duoset-ic-elisa_dyc8965-2">DYC8965</a></td> <td> </td> </tr> <tr> <td>PDGF R beta (Y751)</td> <td><a href="/products/human-total-pdgf-r-beta-duoset-ic-elisa_dyc385-2">DYC385</a></td> <td><a href="/products/human-phospho-pdgf-r-beta-y751-duoset-ic-elisa_dyc3096-22">DYC3096</a></td> <td> </td> </tr> <tr> <td>PLC gamma-1 (Y783)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>PRAS40 (T246)</td> <td> </td> <td><a href="/products/human-phospho-pras40-t246-duoset-ic-elisa_dyc6890-2">DYC6890</a></td> <td> </td> </tr> <tr> <td>PYK2 (Y402)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>RSK1/2 (S221/S227)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>RSK1/2/3 (S380/S386/S377)</td> <td> </td> <td><a href="/products/phospho-rsk-s380-pan-specific-duoset-ic-elisa_dyc889b-2">DYC889B</a></td> <td> </td> </tr> <tr> <td>Src (Y419)</td> <td> </td> <td><a href="/products/human-phospho-src-y419-duoset-ic-elisa_dyc2685-2">DYC2685</a></td> <td> </td> </tr> <tr> <td>STAT1 (Y701)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>STAT2 (Y690)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>STAT3 (S727)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>STAT3 (Y705)</td> <td> </td> <td><a href="/products/human-mouse-phospho-stat3-y705-duoset-ic-elisa_dyc4607b-2">DYC4607B</a></td> <td> </td> </tr> <tr> <td>STAT5a/b (Y694/Y699)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>STAT6 (Y641)</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td>WNK-1(T60)</td> <td> </td> <td><a href="/products/human-mouse-rat-phospho-wnk1-t60-duoset-ic-elisa_dyc4720-2">DYC4720</a></td> <td> </td> </tr> <tr> <td>Yes (Y426)</td> <td> </td> <td><a href="/products/human-phospho-yes-y426-duoset-ic-elisa_dyc3929-2">DYC3929</a></td> <td> </td> </tr> </tbody> </table> </div> <h3 class="subheader18 mt-1">Specifications</h3> <div class="ds_table summary_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data">N/A</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Shipping Conditions</div> <div class="ds_table_cell summary_table_data">The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Storage</div> <div class="ds_table_cell summary_table_data">Store the unopened product at 2 - 8 °C. Do not use past expiration date.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Species</div> <div class="ds_table_cell summary_table_data">Human</div> </div> </div> </div> </div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/ary003c.pdf?v=20241123" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/proteome-profiler-human-phospho-kinase-array-kit_ary003c">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="//resources.rndsystems.com/pdfs/msds/ary003c.pdf?v=20241123">SDS</a> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="ARY003C"></div> <div id="ds_scientific_data" class="datasheet_section"> <div id="ds_data_examples"> <h2>Scientific Data</h2> <div id="data_examples"> <div class="row data_ex_row"> <a id="ds_image_0" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> N/A </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-0" data-title="Detection of Human Protein Kinase Phosphorylation in A549 Cell Line." data-footer="Detection of human protein kinase phosphorylation in A549 Cell Line." title="Cat. No. - Detection of human protein kinase phosphorylation in A549 Cell Line." href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141555.png"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141555.png" class="img-fluid" alt="Detection of human protein kinase phosphorylation in A549 Cell Line." title="Detection of human protein kinase phosphorylation in A549 Cell Line."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human Protein Kinase Phosphorylation in A549 Cell Line.</span> A549 human lung adenocarcinoma cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 24 hour recovery before lysis. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_1" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> N/A </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-1" data-title="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." data-footer="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." title="Cat. No. - Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141653.png"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141653.png" class="img-fluid" alt="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line." title="Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line.</span> Daudi human B cell lymphoma cells were either left untreated or treated with 500 U/ml Recombinant Human IFN-alpha 2a (R&D Systems, Catalog # 11100-1) for 5 minutes. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_2" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> N/A </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-2" data-title="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." data-footer="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." title="Cat. No. - Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141746.png"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141746.png" class="img-fluid" alt="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line." title="Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line.</span> Jurkat human acute T cell leukemia cells were either left untreated or treated with 100 ng/mL PMA and 0.5 mM Ionomycin for 20 minutes. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_3" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> N/A </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-3" data-title="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." data-footer="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." title="Cat. No. - Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." href="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141850.png"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/ary003c_proteome-profiler-human-phospho-kinase-array-kit-9112020141850.png" class="img-fluid" alt="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line." title="Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line."> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> <span class="data_ex_description_title">Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line.</span> MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of recombinant human IGF-1 (R&D Systems®, Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/recombinant-human-igf-i-igf-1-protein-cf_291-g1">291-G1</a>) for 1 hour. </p> </div> </div> </div> </div> </div> <div id="ds_related_research_areas" class="datasheet_section"> <h2>Related Research Areas</h2> <ul class="ds_details"> <li> <a href="/research-area/adhesion-molecules-on-endothelial-cells">Adhesion Molecules on Endothelial Cells</a> </li> <li> <a href="/research-area/adhesion-molecules-on-vsmc">Adhesion Molecules on VSMC</a> </li> <li> <a href="/research-area/kinases-and-phosphatases-in-endothelial-cells">Kinases and Phosphatases in Endothelial Cells</a> </li> <li> <a href="/research-area/kinases-and-phosphatases-in-vsmc">Kinases and Phosphatases in VSMC</a> </li> <li> <a href="/research-area/platelet-signaling">Platelet Signaling</a> </li> <li> <a href="/research-area/positive-regulators-of-the-jak-stat-pathway">Positive Regulators of the Jak/STAT Pathway</a> </li> </ul> </div> </div>   <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for Proteome Profiler Human Phospho-Kinase Array Kit</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. </p> <p> <strong><span id="maxcitations">389</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">10</span> </strong> <br/><strong>Filter your results:</strong> </p> <div class="row"> <div class="col-sm-12"> <div class="citations_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper filter_select"> <select id="selSpecies" title="Species"> <option value="All">All Species</option> <option class="citation_filterRadio" value="species" data-filter="Human"> Human </option> <option class="citation_filterRadio" value="species" data-filter="Mouse"> Mouse </option> <option class="citation_filterRadio" value="species" data-filter="Phoenix dactylifera (Date palm)"> Phoenix dactylifera (Date palm) </option> <option class="citation_filterRadio" value="species" data-filter="Rat"> Rat 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Homogenates"> Tissue Homogenates </option> <option class="citation_filterRadio" value="sampletype" data-filter="Tissue Homogenates, Whole Tissue"> Tissue Homogenates, Whole Tissue </option> <option class="citation_filterRadio" value="sampletype" data-filter="Tissue Lysates"> Tissue Lysates </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cell Extracts"> Whole Cell Extracts </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> </select> </div> </div> </div> </div> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="389" data-max-show="10"> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/39333184"> Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain </a> </span><br/> Authors: Jones, K;Keddy, C;Jenkins, C;Nicholson, K;Shinde, U;Davare, MA;<br/> Scientific reports  2024-09-27 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/39138174"> PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression </a> </span><br/> Authors: Ross, MO;Xie, Y;Owyang, RC;Ye, C;Zbihley, ONP;Lyu, R;Wu, T;Wang, P;Karginova, O;Olopade, OI;Zhao, M;He, C;<br/> Nature communications  2024-08-13 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/39199311"> Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer </a> </span><br/> Authors: Rodríguez-Sarmiento, DY;Rondón-Villarreal, P;Scarpelli-Pereira, PH;Bouvier, M;<br/> Biomolecules  2024-07-29 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/39032475"> APG-1252 combined with Cabozantinib inhibits hepatocellular carcinoma by suppressing MEK/ERK and CREB/Bcl-xl pathways </a> </span><br/> Authors: Di, T;Luo, QY;Song, JT;Yan, XL;Zhang, L;Pan, WT;Guo, Y;Lu, FT;Sun, YT;Xia, ZF;Yang, LQ;Qiu, MZ;Yang, DJ;Sun, J;<br/> International immunopharmacology  2024-07-19 <br/> </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38906855"> Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma </a> </span><br/> Authors: Yu, L;Deng, Y;Wang, X;Santos, C;Davis, IJ;Earp, HS;Liu, P;<br/> Nature communications  2024-06-21 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38796478"> Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer </a> </span><br/> Authors: Standing, D;Dandawate, P;Gunewardena, S;Covarrubias-Zambrano, O;Roby, KF;Khabele, D;Jewell, A;Tawfik, O;Bossmann, SH;Godwin, AK;Weir, SJ;Jensen, RA;Anant, S;<br/> Cell death & disease  2024-05-25 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38391925"> Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB Pathway </a> </span><br/> Authors: Sidgwick, GP;Weston, R;Mahmoud, AM;Schiro, A;Serracino-Inglott, F;Tandel, SM;Skeoch, S;Bruce, IN;Jones, AM;Alexander, MY;Wilkinson, FL;<br/> Cells  2024-02-08 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38242884"> DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts </a> </span><br/> Authors: Shumliakivska, M;Luxán, G;Hemmerling, I;Scheller, M;Li, X;Müller-Tidow, C;Schuhmacher, B;Sun, Z;Dendorfer, A;Debes, A;Glaser, SF;Muhly-Reinholz, M;Kirschbaum, K;Hoffmann, J;Nagel, E;Puntmann, VO;Cremer, S;Leuschner, F;Abplanalp, WT;John, D;Zeiher, AM;Dimmeler, S;<br/> Nature communications  2024-01-19 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Amino Acid"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38218903"> Brain-targeted delivery of neuroprotective survival gene minimizing hematopoietic cell contamination: implications for Parkinson's disease treatment </a> </span><br/> Authors: Lee, MH;Kang, S;Um, KH;Lee, SW;Hwang, H;Baek, K;Choi, JW;<br/> Journal of translational medicine  2024-01-13 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/38178183"> ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy </a> 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Á;Seprényi, G;Rázga, Z;Ayaydin, F;Veréb, Z;Megyeri, K;<br/> Biomedicines  2023-11-10 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37833751"> EGCG inhibits the inflammation and senescence inducing properties of MDA-MB-231 triple-negative breast cancer (TNBC) cells-derived extracellular vesicles in human adipose-derived mesenchymal stem cells </a> </span><br/> Authors: Gonzalez Suarez, N;Fernandez-Marrero, Y;Hébert, MPA;Roy, ME;Boudreau, LH;Annabi, B;<br/> Cancer cell international  2023-10-13 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37615251"> Fumarate hydratase functions as a tumor suppressor in endometrial cancer by inactivating EGFR signaling </a> </span><br/> Authors: Wang, YY;Vadhan, A;Wu, CH;Hsu, CY;Chen, YC;Chen, YK;Chen, PY;Nguyen, HDH;Chang, YC;Yuan, SF;<br/> Oncology reports  2023-10-01 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37749143"> Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma </a> </span><br/> Authors: Bassot, A;Dragic, H;Haddad, SA;Moindrot, L;Odouard, S;Corlazzoli, F;Marinari, E;Bomane, A;Brassens, A;Marteyn, A;Hibaoui, Y;Petty, TJ;Chalabi-Dchar, M;Larrouquere, L;Zdobnov, EM;Legrand, N;Tamburini, J;Lincet, H;Castets, M;Yebra, M;Migliorini, D;Dutoit, V;Walker, PR;Preynat-Seauve, O;Dietrich, PY;Cosset, É;<br/> Cell death & disease  2023-09-25 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37759443"> PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia </a> </span><br/> Authors: Pun, SH;O'Neill, KM;Edgar, KS;Gill, EK;Moez, A;Naderi-Meshkin, H;Malla, SB;Hookham, MB;Alsaggaf, M;Madishetti, VV;Botezatu, B;King, W;Brunssen, C;Morawietz, H;Dunne, PD;Brazil, DP;Medina, RJ;Watson, CJ;Grieve, DJ;<br/> Cells  2023-09-06 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37667051"> Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma </a> </span><br/> Authors: Pang, L;Dunterman, M;Guo, S;Khan, F;Liu, Y;Taefi, E;Bahrami, A;Geula, C;Hsu, WH;Horbinski, C;James, CD;Chen, P;<br/> Nature immunology  2023-09-04 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37693440"> PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression </a> </span><br/> Authors: Ross, MO;Xie, Y;Owyang, RC;Ye, C;Zbihley, ONP;Lyu, R;Wu, T;Wang, P;Karginova, O;Olopade, OI;Zhao, M;He, C;<br/> bioRxiv : the preprint server for biology  2023-08-29 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37628961"> Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8+ T Cells in Severe/Critical COVID-19 </a> </span><br/> Authors: Wang, Y;Yang, C;Wang, Z;Wang, Y;Yan, Q;Feng, Y;Liu, Y;Huang, J;Zhou, J;<br/> International journal of molecular sciences  2023-08-14 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37568803"> Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma </a> </span><br/> Authors: Jeon, Y;Kim, T;Kwon, H;Kim, JK;Park, YT;Ham, J;Kim, YJ;<br/> Cancers  2023-08-05 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37542037"> Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer </a> 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class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35953476"> PTEN inhibits AMPK to control collective migration </a> </span><br/> Authors: F Peglion, L Capuana, I Perfettini, L Boucontet, B Braithwait, E Colucci-Gu, E Quissac, K Forsberg-N, F Llense, S Etienne-Ma<br/> Nature Communications, 2022-08-11;13(1):4528.  2022-08-11 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35944584"> p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells </a> </span><br/> Authors: S Pietrobono, R De Paolo, D Mangiameli, A Marranci, I Battisti, C Franchin, G Arrigoni, D Melisi, L Poliseno, B Stecca<br/> The Journal of Biological Chemistry, 2022-08-07;298(9):102353.  2022-08-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35955801"> Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19 </a> </span><br/> Authors: M Almutlaq, FA Mansour, J Alghamdi, Y Alhendi, AA Alamro, AA Alghamdi, HS Alamri, F Alroqi, T Barhoumi<br/> International Journal of Molecular Sciences, 2022-08-04;23(15):.  2022-08-04 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35954442"> Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion </a> </span><br/> Authors: A Jouida, M O'Callagha, C Mc Carthy, A Fabre, P Nadarajan, MP Keane<br/> Cancers, 2022-08-03;14(15):.  2022-08-03 <br/> </li> <li 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Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz<br/> Elife, 2022-07-11;11(0):.  2022-07-11 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35778693"> Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells </a> </span><br/> Authors: C He, C Wang, H Liu, B Shan<br/> BMC Cancer, 2022-07-02;22(1):724.  2022-07-02 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35750747"> Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer </a> </span><br/> Authors: K Kamat, V Krishnan, O Dorigo<br/> British Journal of Cancer, 2022-06-24;0(0):. 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</span><br/> Authors: C Zhao, H Yu, X Fan, W Niu, J Fan, S Sun, M Gong, B Zhao, Z Fang, X Chen<br/> Oncogenesis, 2022-05-23;11(1):28.  2022-05-23 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35568768"> Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells </a> </span><br/> Authors: MK Mamidi, H Mahmud, GP Maiti, MT Mendez, SM Fernandes, SK Vesely, J Holter-Cha, JR Brown, AK Ghosh<br/> Leukemia, 2022-05-14;0(0):.  2022-05-14 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35568711"> m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer </a> </span><br/> Authors: JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang, YB Ma, ZS Xiu, QZ Qiu, HG Wang, CH Zheng, P Li, JW Xie, J Lu, QY Chen, LL Cao, M Lin, JB Wang, CM Huang<br/> Cell Death & Disease, 2022-05-14;13(5):463.  2022-05-14 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35565468"> Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer </a> </span><br/> Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco<br/> Cancers, 2022-05-09;14(9):.  2022-05-09 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35625825"> Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells </a> </span><br/> Authors: C Alonso-Gon, C González-A, J Menéndez-M, A González-G, V Álvarez-Ga, A González-C, C Martínez-C, S Cos<br/> Biomedicines, 2022-05-07;10(5):.  2022-05-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35259248"> Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia </a> </span><br/> Authors: T Braun, J Stachelsch, N Bley, S Oberbeck, M Otte, TA Müller, L Wahnschaff, M Gla beta, K Ommer, M Franitza, B Gathof, J Altmüller, M Hallek, D Auguin, S Hüttelmaie, A Schrader, M Herling<br/> Cancer Research, 2022-05-03;0(0):.  2022-05-03 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35487888"> ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer </a> </span><br/> Authors: EJ Lim, JH Kang, YJ Kim, S Kim, SJ Lee<br/> Cell Death & Disease, 2022-04-29;13(4):417.  2022-04-29 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35454174"> The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway </a> </span><br/> Authors: S Bini, V Pecce, A Di Costanz, L Polito, A Ghadiri, I Minicocci, F Tambaro, S Covino, M Arca, L D'Erasmo<br/> Biomolecules, 2022-04-16;12(4):.  2022-04-16 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35417708"> Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model </a> </span><br/> Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann<br/> Cell Reports, 2022-04-12;39(2):110670.  2022-04-12 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35547758"> Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion </a> </span><br/> Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira<br/> Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35305629"> SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway </a> </span><br/> Authors: Z Liu, Q Wang, G Zhai, S Ke, X Yu, J Guo<br/> Cancer Cell International, 2022-03-19;22(1):127.  2022-03-19 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="" data-sampletype="Serum"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35302851"> ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers </a> </span><br/> 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inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3 </a> </span><br/> Authors: CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi<br/> JCI Insight, 2022-02-08;0(0):.  2022-02-08 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34841430"> Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability </a> </span><br/> Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar<br/> Disease Models & Mechanisms, 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data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35008494"> Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells </a> </span><br/> Authors: K Marunaka, S Shu, M Kobayashi, M Goto, Y Katsuta, Y Yoshino, A Ikari<br/> International Journal of Molecular Sciences, 2021-12-22;23(1):.  2021-12-22 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35008182"> GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma </a> </span><br/> Authors: HM Ahn, EY Choi, YJ Kim<br/> Cancers, 2021-12-21;14(1):.  2021-12-21 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34944965"> SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase </a> </span><br/> Authors: Y Ounoughene, E Fourgous, Y Boublik, E Saland, N Guiraud, C Recher, S Urbach, P Fort, JE Sarry, D Fesquet, S Roche<br/> Cancers, 2021-12-17;13(24):.  2021-12-17 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34878832"> Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence </a> </span><br/> Authors: D Bakhshinya, AA Adile, J Liu, WD Gwynne, Y Suk, S Custers, I Burns, M Singh, N McFarlane, MK Subapandit, MA Qazi, P Vora, MM Kameda-Smi, N Savage, KL Desmond, N Tatari, D Tran, M Seyfrid, K Hope, NA Bock, C Venugopal, GD Bader, SK Singh<br/> Science Advances, 2021-12-08;7(50):eabi5568.  2021-12-08 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34802033"> Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer </a> </span><br/> Authors: YZ Mazzu, YR Liao, S Nandakumar, LE Jehane, RP Koche, SH Rajanala, R Li, H Zhao, TA Gerke, G Chakrabort, GM Lee, GJ Nanjangud, A Gopalan, Y Chen, PW Kantoff<br/> Oncogene, 2021-11-20;0(0):.  2021-11-20 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34799660"> Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer </a> </span><br/> Authors: L Yin, Y Zeng, R Zeng, Y Chen, TL Wang, KJ Rodabaugh, F Yu, A Natarajan, AR Karpf, J Dong<br/> Oncogene, 2021-11-19;0(0):.  2021-11-19 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34830899"> The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis </a> </span><br/> Authors: N Stoup, M Liberelle, C Schulz, S Cavdarli, R Vasseur, R Magnez, F Lahdaoui, N Skrypek, F Peretti, F Frénois, X Thuru, P Melnyk, N Renault, N Jonckheere, N Lebègue, I Van Seunin<br/> Cancers, 2021-11-16;13(22):.  2021-11-16 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34764490"> Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells </a> </span><br/> Authors: D Chauss, T Freiwald, R McGregor, B Yan, L Wang, E Nova-Lampe, D Kumar, Z Zhang, H Teague, EE West, KM Vannella, MJ Ramos-Beni, J Bibby, A Kelly, A Malik, AF Freeman, DM Schwartz, D Portilla, DS Chertow, S John, P Lavender, C Kemper, G Lombardi, NN Mehta, N Cooper, MS Lionakis, A Laurence, M Kazemian, B Afzali<br/> Nature Immunology, 2021-11-11;0(0):.  2021-11-11 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34716325"> The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation </a> </span><br/> Authors: V Vorstandle, M Laggner, D Copic, K Klas, M Direder, Y Chen, B Golabi, W Haslik, C Radtke, E Tschachler, K Hötzenecke, HJ Ankersmit, M Mildner<br/> Nature Communications, 2021-10-29;12(1):6242.  2021-10-29 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34711817"> Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation </a> </span><br/> Authors: J Kim, YJ Jeon, SC Lim, J Ryu, JH Lee, IY Chang, HJ You<br/> Cell Death & Disease, 2021-10-28;12(11):1013.  2021-10-28 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34829770"> IL-36alpha and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling </a> </span><br/> Authors: ZII Al-Luhaibi, Á Dernovics, G Seprényi, F Ayaydin, Z Boldogk?i, Z Veréb, K Megyeri<br/> Biomedicines, 2021-10-26;9(11):.  2021-10-26 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Tissue Homogenates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34656143"> Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation </a> </span><br/> Authors: A Quintanal-, H Taniguchi, YA Zhan, MM Hasan, SS Chavan, F Meng, F Uddin, V Allaj, P Manoj, NS Shah, JM Chan, M Ciampricot, A Chow, M Offin, J Ray-Kirton, JD Egger, UK Bhanot, I Linkov, M Asher, MH Roehrl, K Ventura, J Qiu, E de Stanchi, JC Chang, N Rekhtman, B Houck-Loom, RP Koche, HA Yu, T Sen, CM Rudin<br/> Journal of hematology & oncology, 2021-10-16;14(1):170.  2021-10-16 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34477203"> Tyrosine kinase independent actions of DDR2 in tumor cells and CAFs influence tumor invasion, migration, and metastasis </a> </span><br/> Authors: CE Barcus, PY Hwang, V Morikis, A Brenot, P Pence, M Clarke, GD Longmore<br/> Journal of Cell Science, 2021-10-13;0(0):.  2021-10-13 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34680264"> Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma </a> </span><br/> Authors: A Pandey, SC Tripathi, J Mai, SM Hanash, H Shen, S Mitra, RC Rostomily<br/> Cancers, 2021-10-12;13(20):.  2021-10-12 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34681618"> Androgen Receptor Activation in Glioblastoma Can Be Achieved by Ligand-Independent Signaling through EGFR-A Potential Therapeutic Target </a> </span><br/> Authors: N Zalcman, M Gutreiman, T Shahar, M Weller, I Lavon<br/> International Journal of Molecular Sciences, 2021-10-11;22(20):.  2021-10-11 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Tissue Homogenates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34593832"> Preclinical development of a bispecific TNFalpha/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease </a> </span><br/> Authors: KJ Roberts, MF Cubitt, TM Carlton, L Rodrigues-, L Maggiore, R Chai, S Clare, K Harcourt, TT MacDonald, KP Ray, A Vossenkämp, MR West, JS Crowe<br/> Scientific Reports, 2021-09-30;11(1):19422.  2021-09-30 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34407412"> CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance </a> </span><br/> Authors: S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood<br/> Cell Reports, 2021-08-17;36(7):109549.  2021-08-17 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34354046"> Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway </a> </span><br/> Authors: F Luo, FT Lu, MZ Qiu, T Zhou, WJ Ma, M Luo, KM Zeng, QY Luo, WT Pan, L Zhang, ZF Xia, ZH Zhang, JX Cao, HY Zhao, L Zhang, DJ Yang<br/> Cell Death & Disease, 2021-08-05;12(8):772.  2021-08-05 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34321458"> PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance </a> </span><br/> Authors: C Yoon, J Lu, SW Ryeom, MC Simon, SS Yoon<br/> Cell Death & Disease, 2021-07-29;12(8):749.  2021-07-29 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34373751"> Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration </a> </span><br/> Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk<br/> Theranostics, 2021-07-25;11(17):8430-8447.  2021-07-25 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34290311"> CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1 </a> </span><br/> Authors: S Durlanik, K Fundel-Cle, C Viollet, HJ Huber, M Lenter, K Kitt, S Pflanz<br/> Scientific Reports, 2021-07-21;11(1):14849.  2021-07-21 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34285210"> TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer </a> </span><br/> Authors: J Xu, X Yang, Q Deng, C Yang, D Wang, G Jiang, X Yao, X He, J Ding, J Qiang, J Tu, R Zhang, QY Lei, ZM Shao, X Bian, R Hu, L Zhang, S Liu<br/> Nature Communications, 2021-07-20;12(1):4413.  2021-07-20 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34335531"> Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling </a> </span><br/> Authors: C Stecher, S Marinkov, L Mayr-Harti, A Katic, MT Kastner, FJJ Rieder-Rom, X Lin, S Nekhai, C Steininger<br/> Frontiers in Microbiology, 2021-07-15;12(0):698603.  2021-07-15 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34298757"> New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling </a> </span><br/> Authors: M Mahdal, J Neradil, P Mudry, S Paukovceko, I Staniczkov, J Urban, P Macsek, L Pazourek, T Tomas, R Veselska<br/> Cancers, 2021-07-15;13(14):.  2021-07-15 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34257270"> miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer </a> </span><br/> Authors: J Guo, X Zhong, Q Tan, S Yang, J Liao, J Zhuge, Z Hong, Q Deng, Q Zuo<br/> Cell Death & Disease, 2021-07-13;12(7):696.  2021-07-13 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34359918"> RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells </a> </span><br/> Authors: E Demirel, C Arnold, J Garg, MA Jäger, C Sticht, R Li, H Kuk, N Wettschure, M Hecker, T Korff<br/> Cells, 2021-07-11;10(7):.  2021-07-11 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34133426"> Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells </a> </span><br/> Authors: H Sevim, H Çelik, L Dü?ünceli, CS Ceyhan, A Molotkova, K Nakazawa, GT Graham, JR Petro, JA Toretsky, A Üren<br/> PLoS ONE, 2021-06-16;16(6):e0253170.  2021-06-16 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34098956"> Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis </a> </span><br/> Authors: K Andelid, K Öst, A Andersson, E Mohamed, Z Jevnikar, LEGW Vanfletere, M Göransson<br/> Respiratory Research, 2021-06-07;22(1):172.  2021-06-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Tissue Homogenates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34031501"> Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes </a> </span><br/> Authors: TW Jones, L Eddens, J Kupusarevi, DCM Simoes, MJW Furber, KA van Somere, G Howatson<br/> Scientific Reports, 2021-05-24;11(1):10785.  2021-05-24 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34094684"> Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail </a> </span><br/> Authors: YJ Lai, CH Chao, CC Liao, TA Lee, JM Hsu, WC Chou, J Wang, HC Huang, SJ Chang, YL Lin, CW Li<br/> American journal of cancer research, 2021-05-15;11(5):2278-2290.  2021-05-15 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34063063"> New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer </a> </span><br/> Authors: L Gheysen, L Soumoy, A Trelcat, L Verset, F Journe, S Saussez<br/> Cells, 2021-05-05;10(5):.  2021-05-05 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/34025398"> The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells </a> </span><br/> Authors: S Hafner, M Schmiech, SJ Lang<br/> Frontiers in Pharmacology, 2021-05-05;12(0):611657.  2021-05-05 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33610554"> Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion </a> </span><br/> Authors: SI Noor, M Hoffmann, N Rinis, MF Bartels, PR Winterhalt, C Hoelscher, R Hennig, N Himmelreic, C Thiel, T Ruppert, E Rapp, S Strahl<br/> The Journal of Biological Chemistry, 2021-02-18;0(0):100433.  2021-02-18 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33563293"> Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines </a> </span><br/> Authors: F Benedetti, S Curreli, RC Gallo, D Zella<br/> Journal of Translational Medicine, 2021-02-09;19(1):60.  2021-02-09 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33568624"> TGF-&beta1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor </a> </span><br/> Authors: H Yoon, CM Tang, S Banerjee, AL Delgado, M Yebra, J Davis, JK Sicklick<br/> Oncogenesis, 2021-02-06;10(2):13.  2021-02-06 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Culture Supernates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33545231"> mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism </a> </span><br/> Authors: MA Chawsheen, PR Dash<br/> Cellular Signalling, 2021-02-03;81(0):109934.  2021-02-03 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Extract"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33482197"> Identification of Radil as a Ras binding partner and putative activator </a> </span><br/> Authors: BH Choi, Z Kou, TM Colon, CH Chen, Y Chen, W Dai<br/> The Journal of Biological Chemistry, 2021-01-20;0(0):100314.  2021-01-20 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33446797"> S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells </a> </span><br/> Authors: SH Jo, WH Heo, HY Son, M Quan, BS Hong, JH Kim, HB Lee, W Han, Y Park, DS Lee, NH Kwon, MC Park, J Chae, JI Kim, DY Noh, HG Moon<br/> Scientific Reports, 2021-01-14;11(1):1337.  2021-01-14 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33431813"> BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways </a> </span><br/> Authors: CY Jiao, QC Feng, CX Li, D Wang, S Han, YD Zhang, WJ Jiang, J Chang, X Wang, XC Li<br/> Cell Death & Disease, 2021-01-11;12(1):63.  2021-01-11 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysate"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33431808"> Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells </a> </span><br/> Authors: J Wang, X Lv, X Guo, Y Dong, P Peng, F Huang, P Wang, H Zhang, J Zhou, Y Wang, B Wei, ZF Shang, S Li<br/> Oncogenesis, 2021-01-05;10(1):8.  2021-01-05 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33500726"> CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3&beta/&beta-catenin/OCT4 axis </a> </span><br/> Authors: W Shen, X Zhang, J Tang, Z Zhang, R Du, D Luo, X Liu, Y Xia, Y Li, S Wang, S Yan, W Yang, R Xiang, N Luo, Y Luo, J Li<br/> Theranostics, 2021-01-01;11(5):2297-2317.  2021-01-01 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/33361772"> Schistosoma mansoni eggs induce Wnt/&beta-catenin 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Exp. Clin. Cancer Res., 2020-05-07;39(1):79.  2020-05-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/32368861"> The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells </a> </span><br/> Authors: A Douida, F Batista, A Robaszkiew, P Boto, A Aladdin, M Szenykiv, R Czinege, L Virág, K Tar<br/> J. Cell. Mol. 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target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24945252"> The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. </a> </span><br/> Authors: Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, Kovanci E, Lee K, Threadgill D, Lydon J, Jeong J, DeMayo F<br/> 2014-06-19;0(0):.  2014-06-19 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24905466"> Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo. </a> </span><br/> Authors: Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, Borghi M, Lozupone F, Carotti S, Morini S, Gaudio E, Calvieri S, Londei P<br/> PLoS ONE, 2014-06-06;9(6):e98641.  2014-06-06 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24863063"> Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. </a> </span><br/> Authors: Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C<br/> J Exp Med, 2014-05-26;211(6):1167-83.  2014-05-26 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24847057"> Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes. </a> </span><br/> Authors: Jokela 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Yunfeng<br/> PLoS ONE, 2014-04-07;9(4):e94079.  2014-04-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24524758"> The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells. </a> </span><br/> Authors: Kim, Ji Hye, Kim, Wang-Kyu, Sung, Young Kw, Kwack, Mi Hee, Song, Seung Yo, Choi, Joon-Seo, Park, Sang Gyu, Yi, TacGhee, Lee, Hyun-Joo, Kim, Dae-Duk, Seo, Hyun Min, Song, Sun U, Sung, Jong-Hyu<br/> Stem Cells Dev, 2014-03-21;23(12):1364-76.  2014-03-21 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24618420"> Downstream signaling and genome-wide regulatory effects of 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herpesvirus and enhances the invasiveness of infected endothelial cells. </a> </span><br/> Authors: Haas D, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz T<br/> PLoS Pathog, 2013-11-07;9(11):e1003737.  2013-11-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24192080"> Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines. </a> </span><br/> Authors: Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, Grenman R, van der Kogel A, Span P, Bussink J<br/> Mol Cancer, 2013-11-05;12(1):133.  2013-11-05 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" 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Meeuwsen-de Boer T, Kamps W, Schuringa J, de Bont E<br/> Mol Cancer Res, 2013-02-07;11(4):339-48.  2013-02-07 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23382047"> Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway. </a> </span><br/> Authors: Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, Li S, Li J, Bowden G, Dong Z, Dong Z<br/> Cancer Res, 2013-02-04;73(7):2181-8.  2013-02-04 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="" data-sampletype="Tissue Homogenates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23376846"> Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. </a> </span><br/> Authors: Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L<br/> Oncogene, 2013-02-04;33(7):823-31.  2013-02-04 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23345406"> CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons. </a> </span><br/> Authors: Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P<br/> J Cell Sci, 2013-01-23;126(0):1199-206.  2013-01-23 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23195957"> Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. </a> </span><br/> Authors: Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano J, Mammoto A, Bielenberg D, Klagsbrun M<br/> J Biol Chem, 2012-11-29;288(4):2210-22.  2012-11-29 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/23056179"> Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. </a> </span><br/> Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory<br/> PLoS ONE, 2012-10-02;7(10):e44372.  2012-10-02 <br/> </li> <li class="top-lined" data-species="Human" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a 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Chem., 2009-04-27;284(26):17527-39.  2009-04-27 <br/> </li> <li class="top-lined" data-species="Mouse" data-application="" data-sampletype="Cell Lysates"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/19258523"> Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists. </a> </span><br/> Authors: Couty JP, Lupu-Meiri M, Oron Y, Gershengorn MC<br/> J. Pharmacol. Exp. Ther., 2009-03-03;329(3):1142-7.  2009-03-03 <br/> </li> </div> </ol> </div> <div class="clearfix"><button class="btn btn-quinary ds_extra_cits pull-right toggle_cits_down" id="toggle_cits"></button></div> </div> </div>  <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <ol id="faq_list"> <li> <span class="faq_question"><p>Why are there 8 membranes provided in ARY003C?</p></span> <ul class="faq_answer"> <li><p>ARY003C contains 8 membranes because it is divided into parts A and B with 4 membranes each. Both parts are spotted with different antibodies to avoid interference and cross reactivity as well as maximize sensitivity. Parts A and B each contain 39 different capture antibodies printed in duplicate and should be used together for optimal analysis efficiency. A total of four samples can be run with this kit. </p></li> </ul> </li> </ol> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/proteome-profiler-antibody-arrays"> View all Proteome Profiler Antibody Array FAQs </a> </div> </div> </div>   <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for Proteome Profiler Human Phospho-Kinase Array Kit</h3> <div class="row"> <div class="col-xs-12"> <div class="datasheet_section"> <div class="row"> <div class="col-md-6"> <p> Average Rating: 4.7 <span class="review_stars_5"></span> (Based on 10 Reviews) </p> <div class="review_rating_progress"> <div class="row"> <div class="col-xs-3"> 5 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="80" aria-valuemin="0" aria-valuemax="100" style="width:80%"> </div> </div> </div> <div class="col-xs-3"> 80% </div> </div> <div class="row"> <div class="col-xs-3"> 4 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="10" aria-valuemin="0" aria-valuemax="100" style="width:10%"> </div> </div> </div> <div class="col-xs-3"> 10% </div> </div> <div class="row"> <div class="col-xs-3"> 3 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="10" aria-valuemin="0" aria-valuemax="100" style="width:10%"> </div> </div> </div> <div class="col-xs-3"> 10% </div> </div> <div class="row"> <div class="col-xs-3"> 2 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 1 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> </div> </div> <div class="col-md-6"> <div class="well"> <h4>Have you used Proteome Profiler Human Phospho-Kinase Array Kit?</h4> <h5><strong>Submit a review and receive an Amazon gift card.</strong></h5> <div class="review_reward_txt"> <p>$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image</p> <p>$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image</p> </div> <a class="btn btn-quinary" href="/reviews/ARY003C"> Submit a Review </a> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <div class="reviews_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper"> <select class="review_filter_rating"> <option value="all">All Ratings</option> <option value="5">5</option> <option value="4">4</option> <option value="3">3</option> </select> </div> <div class="select_wrapper"> <select class="review_filter_application"> <option value="all">All Applications</option> </select> </div> </div> </div> </div> <br/> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 04/24/2023 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 08/02/2022 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> <div class="review_how_used"><p>Used human lymphoma samples! Worked fine!</p></div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_74536.png" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_74536.png"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 08/02/2022 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> <div class="review_how_used"><p>Used this kit with mouse lymphoma cell lines and it worked!</p></div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_71501.jpg" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_71501.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 09/16/2021 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 07/15/2021 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_64476_0.png" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_64476_0.png"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 03/21/2021 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_62476_0.jpg" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_62476_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 01/27/2021 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_61366_0.jpg" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_61366_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="4" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_4">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">APK Inmunometabolismo</span> on 11/06/2020 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> </div> <hr/> </div> <div class="review_row" data-rating="3" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_3">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 03/18/2020 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> <div class="review_how_used"><p>Some of the antibodies lack sensitivity. Independent comprobation using the exact same protocol (lysis buffer, etc) and conventional WB rendered higher activation than the kit's</p></div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_51696_0.jpg" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_51696_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Proteome Profiler Human Phospho-Kinase Array Kit</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 01/21/2020 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_50251_0_0_0_0.png" data-title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" title="Proteome Profiler Human Phospho-Kinase Array Kit ARY003C" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_ary003c_50251_0_0_0_0.png"/> </a> </div> </div> <hr/> </div> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3">  <div class="distributor_region"></div>   <div class="widget"> <div class="widget_title">Related Products</div> <div class="widget_content" id="related_products_area"> <ul 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href="https://www.rndsystems.com/pathways/inflammasome-activation-pathways"> <span class="pathway_title">Inflammasome Activation Pathways</span> <img class="pathway_image" loading="lazy" alt="Inflammasome Activation Pathways" src="//resources.rndsystems.com/images/Pathways/Thumbnails/inflammasome-activation-pathways.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/jak-stat-signaling-pathway"> <span class="pathway_title">Jak/STAT Signaling Pathway</span> <img class="pathway_image" loading="lazy" alt="Jak/STAT Signaling Pathway" src="//resources.rndsystems.com/images/Pathways/Thumbnails/jak-stat-signaling-pathways.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/mapk-mitogens-pathway"> <span class="pathway_title">MAPK Signaling: Mitogens</span> <img class="pathway_image" loading="lazy" alt="MAPK Signaling: Mitogens" src="//resources.rndsystems.com/images/Pathways/Thumbnails/mapk-signaling-mitogens.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/mapk-oxidative-stress-pathway"> <span class="pathway_title">MAPK Signaling: Oxidative Stress</span> <img class="pathway_image" loading="lazy" alt="MAPK Signaling: Oxidative Stress" src="//resources.rndsystems.com/images/Pathways/Thumbnails/mapk-signaling-oxidative-stress.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/mtor-signaling"> <span class="pathway_title">mTOR Signaling</span> <img class="pathway_image" loading="lazy" alt="mTOR Signaling" src="//resources.rndsystems.com/images/Pathways/Thumbnails/mtor-signaling.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/nod-like-receptor-signaling-pathway"> <span class="pathway_title">NOD-like Receptor Signaling Pathways</span> <img class="pathway_image" loading="lazy" alt="NOD-like Receptor Signaling Pathways" src="//resources.rndsystems.com/images/Pathways/Thumbnails/nod-like-receptors.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/notch-signaling-pathway"> <span class="pathway_title">Notch Signaling Pathways</span> <img class="pathway_image" loading="lazy" alt="Notch Signaling Pathways" src="//resources.rndsystems.com/images/Pathways/Thumbnails/notch-signaling-pathways.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways"> <span class="pathway_title">Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways</span> <img class="pathway_image" loading="lazy" alt="Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways" src="//resources.rndsystems.com/images/Pathways/Thumbnails/pathogen-damage-activated-c-type.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/tgf-beta-signaling-pathway"> <span class="pathway_title">TGF-beta Signaling Pathways</span> <img class="pathway_image" loading="lazy" alt="TGF-beta Signaling Pathways" src="//resources.rndsystems.com/images/Pathways/Thumbnails/tgf-beta-sginaling-pathways.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/th1-differentiation"> <span class="pathway_title">Th1 Differentiation</span> <img class="pathway_image" loading="lazy" alt="Th1 Differentiation" src="//resources.rndsystems.com/images/Pathways/Thumbnails/th1-differentiation.png"> </a> </li> <li class="pathway_wrapper"> <a class="pathway_link" href="https://www.rndsystems.com/pathways/th17-differentiation"> <span class="pathway_title">Th17 Differentiation</span> <img 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Proteome Profiler Human Phospho-Kinase Array Kit ARY003C: R&D Systems