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<div class="grid-container"> <div class="grid-x"> <div class="cell"> <nav aria-label="breadcrumbs" id="breadcrumbs"><span><span><a href="https://www.wcrf.org/">Home</a></span> <span><a href="https://www.wcrf.org/research-policy/">Research and policy</a></span> <span><a href="https://www.wcrf.org/research-policy/global-cancer-update-programme/">Global Cancer Update Programme</a></span> <span class="breadcrumb_last" aria-current="page">About the Global Cancer Update Programme</span></span></nav> </nav> </div> </div> </div> </div><section class="hero header-secondary color-sky-blue-bg"> <div class="item"> <div class="grid-container"> <div class="grid-x grid-margin-x"> <div class="cell small-order-2 large-order-1 large-6 vertical-align"> <div class="content color-transparent-bg"> <h1>About the Global Cancer Update Programme</h1> <div class="subtitle bold-600 collapse-margin-bottom"><p>World Cancer Research Fund International’s Global Cancer Update Programme analyses global research on how diet, nutrition and physical activity affect cancer risk and survival.</p> </div> </div> </div> <div class="cell small-order-1 large-order-2 large-6">  <div class="media"> <img fetchpriority="high" decoding="async" width="590" height="393" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-Global_590.jpg" class="attachment-large size-large" alt="CUP Global logo" srcset="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-Global_590.jpg 590w, https://www.wcrf.org/wp-content/uploads/2024/10/CUP-Global_590-300x200.jpg 300w" sizes="(max-width: 590px) 100vw, 590px" /> </div> </div> </div> </div> </div> <div class="grid-container"> <div class="grid-x grid-margin-x"> <div class="cell"> <div class="quick-links rounded-s overflow-hidden spacing-m spacing-m-left spacing-m-right"> <h2 class="quick-links-heading">On this page</h2> <ul class="quick-links-list"></ul> </div> </div> </div> </div> </section> <section class="copy copy-text spacing-collapse-bottom"> <div class="grid-container"> <div class="grid-x"> <div class="cell large-8"> <p>The Global Cancer Update Programme (CUP Global), our flagship portfolio of research, was originally established as the Continuous Update Project (CUP). The work undertaken within the CUP informed the development of our groundbreaking Second and Third Expert Reports.</p> <p>CUP Global is a rigorous systematic research programme to gather, analyse and judge the global research on how diet, nutrition, physical activity and body weight affect cancer risk and survival.</p> <p>It’s produced by World Cancer Research Fund International (WCRF International) in partnership with <a href="https://www.aicr.org">American Institute for Cancer Research (AICR)</a>, <a href="/about-us/who-we-are/who-we-are-uk/">World Cancer Research Fund in the UK (WCRF)</a> and <a href="https://www.wkof.nl/">Wereld Kanker Onderzoek Fonds (WKOF)</a> in the Netherlands.</p> </div> </div> </div> </section> <section class="links links-50-50 spacing-collapse-bottom"> <div class="grid-container"> <div class="grid-wrap color-sky-blue-75-bg"> <div class="grid-x align-center align-middle last_item"> <div class="cell medium large-6 large-order-2"> <div class="media-spacer"> <div class="media media-relative ratio-7-5"> <img decoding="async" width="656" height="410" src="https://www.wcrf.org/wp-content/uploads/2024/10/Physical-Activity-656x410-1215123266-1.jpg" class="attachment-large size-large" alt="A family doing exercise in a lounge" srcset="https://www.wcrf.org/wp-content/uploads/2024/10/Physical-Activity-656x410-1215123266-1.jpg 656w, https://www.wcrf.org/wp-content/uploads/2024/10/Physical-Activity-656x410-1215123266-1-300x188.jpg 300w" sizes="(max-width: 656px) 100vw, 656px" /> </div> </div> </div> <div class="cell medium large-6 large-order-1"> <div class="content"> <h3>Evidence for our Recommendations</h3><div class="subtitle "><p>Our groundbreaking Diet and Cancer Report in 2018 analysed thousands of studies to come to our conclusions</p> </div><a href="https://www.wcrf.org/research-policy/evidence-for-our-recommendations/" class="button primary">What’s the evidence?</a> </div> </div> </div> </div> </div> </section> <section class="copy copy-text spacing-collapse-bottom"> <div class="grid-container"> <div class="grid-x"> <div class="cell large-8"> <h2>Experts we work with</h2> <p>Many world-renowned experts contribute to CUP Global. An expert panel evaluates the strength of the evidence from systematic reviews, develops guidance and recommendations, makes recommendations for future research and provides input on the direction of the work.</p> <p>Topic-specific expertise for key areas of work is provided via expert committees.</p> <p>Additional expertise is provided via formal observers to the panel, representing key organisations in the field (<a href="https://www.who.int/">World Health Organization</a>, <a href="https://www.iarc.who.int/">International Agency for Research on Cancer</a>, <a href="https://www.cancer.gov/">National Cancer Institute</a> and <a href="https://www.uicc.org/">Union for International Cancer Control</a>).</p> <div class="spacing-xs-top"> <a class="button primary" href="/about-us/who-we-are/experts-we-work-with/" aria-label="View all the subject experts we work with" target="" > View all the subject experts we work with </a> </div> </div> </div> </div> </section> <section class="copy copy-text spacing-collapse-bottom"> <div class="grid-container"> <div class="grid-x"> <div class="cell large-8"> <hr /> <h2>One-of-a-kind resource</h2> <p><a href="https://www.imperial.ac.uk/school-public-health/epidemiology-and-biostatistics/research/cancer-and-nutritional-epidemiology/global-cancer-update-programme/">Imperial College, London</a> and other collaborators continue to add the most up-to-date published and peer-reviewed literature to our unique CUP Global database. The database is the only one like it in the world and now contains over 12,000 publications, with this number continually growing.</p> <p>Through CUP Global we are able to bring together all the research related to the associations between diet, nutrition, physical activity, body weight, and cancer incidence and survival. This evidence is then used to draw the conclusions that inform our Cancer Prevention Recommendations.</p> <p>Over 140 scientists from countries around the world have contributed to updating the evidence reviews. As new research is produced and published, it will be added to the database. It’s the only authoritative scientific resource of its kind, trusted globally by oncology experts, researchers, health professionals, policy makers, and the public.</p> <p>We have begun to work with a wider set of collaborators across the globe in order to strengthen the evidence-base related to other novel modifiable risk factors and cancer incidence. This includes undertaking reviews in new areas of investigation, such as how exposures in childhood and early life might impact cancer risk in adulthood.</p> <p>Historically, WCRF has not undertaken research to explore the mechanisms that underpin the associations found within population-based research – but this has changed with our new collaboration with <a href="https://www.iarc.who.int">IARC</a>.</p> <p>The results of all these new areas of investigation combine with our ongoing CUP Global work to ensure that our Recommendations are based on the latest evidence from diverse sources.</p> <p>Evidence from CUP Global also enables WCRF to publish reports on individual site-specific cancers. Where the evidence produces strong results, we can then use this to update <a href="/research-policy/evidence-for-our-recommendations/">our Cancer Prevention Recommendations</a>.</p> <p>In the future, we plan to expand these recommendations to include site-specific cancer recommendations, as well as more specific guidance and recommendations for those living with and beyond a cancer diagnosis and those treating them.</p> <hr /> </div> </div> </div> </section> <section class="media-embed spacing-collapse has-header"> <div class="header spacing-collapse-top"> <div class="grid-container"> <div class="grid-x relative align-left"> <div class="cell "> <h2>Watch our launch webinar</h2><p>Our introduction to CUP Global included a fascinating series of presentations from the new Panel and other experts.</p> </div> </div> </div> </div> <div class="grid-container"> <div class="grid-x align-left"> <div class="cell large-8"> <div class="embed-container"> <iframe title="Global Cancer Update Programme (CUP Global) launch webinar: October 2022" width="640" height="360" src="https://www.youtube.com/embed/Zhk5Ryf1VjY?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe> </div> <p class="video-caption">Introducing CUP Global – October 2022</p> </div> </div> </div> </section> <section class="copy copy-text spacing-collapse-bottom"> <div class="grid-container"> <div class="grid-x"> <div class="cell large-8"> <hr /> <h2>Key aims</h2> <p>The 7 key aims of our flagship programme of research within CUP Global are, as follows</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9211 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS-150x150.jpg" alt="" width="50" srcset="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS-150x150.jpg 150w, https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS.jpg 300w" sizes="(max-width: 150px) 100vw, 150px" />The development of population or disease-specific guidance and recommendations</strong> – for specific stages of life (eg children, young adults, older adults), specific populations (eg childhood and adult cancer survivors), and specific cancer subtypes (eg ER, PR positive and triple-negative breast cancer, Lynch syndrome, colon or uterine cancer vs sporadic).</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9210 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS2-150x150.jpg" alt="" width="50" srcset="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS2-150x150.jpg 150w, https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS2.jpg 300w" sizes="(max-width: 150px) 100vw, 150px" />Clarification of existing knowledge to develop greater understanding of cancer prevention and survivorship</strong> – eg the role and impact of specific dietary patterns, the biological mechanisms that cause or prevent cancer.</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9210 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS3-150x150.jpg" alt="" width="50" />Efficient and targeted approaches and keeping the evidence current</strong> – eg through the application of automated approaches and analytical tools, and the use of a dedicated scanning exercise and data prioritisation (including rapid reviews) to target or trigger an evidence update.</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9210 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS4-150x150.jpg" alt="" width="50" />Collaborations and input from experts and external stakeholders</strong> – utilising experts from across the world, as well as continuing to work in collaboration with the team at Imperial College London.</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9210 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS5-150x150.jpg" alt="" width="50" />Varied and targeted outputs</strong> – to enable greater reach and scope within the scientific community (through academic papers), as well as targeted communications for other audiences (including dissemination events).</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9210 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS6-150x150.jpg" alt="" width="50" />Globally representative research</strong> – most epidemiological studies are conducted in high-income countries, such as those in Europe, the US and Australia, with limited or no data from other countries, especially low- and middle-income countries. Cancer incidence and prevalence vary considerably according to geographical region, making the case for future CUP Global studies to address the limited data from low- and middle-income countries.</p> <p><strong><img decoding="async" class="size-thumbnail wp-image-9210 alignleft" src="https://www.wcrf.org/wp-content/uploads/2024/10/CUP-ICONS7-150x150.jpg" alt="" width="50" />Strong public involvement</strong> – we recognise the importance of user involvement at all stages of the work, from identifying research priorities, promoting involvement in funded research and selecting successful research funding applications, to making recommendations and disseminating findings.</p> </div> </div> </div> </section> <section class="cards-text cards has-header"> <div class="header"> <div class="grid-container"> <div class="grid-x relative "> <div class="cell "> <h2>Further CUP Global reading</h2> </div> </div> </div> </div> <div class="grid-container"> <div class="grid-x grid-margin-x grid-margin-y align-center"> <div class="cell medium-6 large-4 repeater-item"> <a href="/research-policy/global-cancer-update-programme/cup-global-the-process/" class="pseudo-link">Steps 1 & 2</a> <div class="card color-sky-blue-75-bg"> <div class="content fixed-button"> <h3 class="h3">The CUP Global process</h3> <p>Understand the 4-step method by which we reach our conclusions</p> <div class="button-group"><a href="/research-policy/global-cancer-update-programme/cup-global-the-process/" class="button primary">Steps 1 & 2</a></div> </div> </div> </div> <div class="cell medium-6 large-4 repeater-item"> <a href="/research-policy/global-cancer-update-programme/history-of-cup-global/" class="pseudo-link">Read the history</a> <div class="card color-sky-blue-75-bg"> <div class="content fixed-button"> <h3 class="h3">CUP Global history</h3> <p>We’ve been producing Recommendations for almost 3 decades</p> <div class="button-group"><a href="/research-policy/global-cancer-update-programme/history-of-cup-global/" class="button primary">Read the history</a></div> </div> </div> </div> <div class="cell medium-6 large-4 repeater-item"> <a href="/about-us/who-we-are/experts-we-work-with/" class="pseudo-link">Who’s who?</a> <div class="card color-sky-blue-75-bg"> <div class="content fixed-button"> <h3 class="h3">Who works on CUP Global?</h3> <p>We couldn’t do it without a dedicated team</p> <div class="button-group"><a href="/about-us/who-we-are/experts-we-work-with/" class="button primary">Who’s who?</a></div> </div> </div> </div> </div> </div> </section> </main>  <footer class="global-footer dark-mode"> <div class="grid-container"> <div class="grid-x grid-margin-x align-justify">  <div class="cell small-9 medium-6 large-4"> <span class="footer-logo"> <a href="https://www.wcrf.org" class="icon"> <img src="https://www.wcrf.org/wp-content/themes/leggo-theme/assets/dist/svgs/preventing-cancer-saving-lives.svg" alt="World Cancer Research Fund"> </a> </span> <p>World Cancer Research Fund is a registered charity in England and Wales (1000739). 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